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Australasian Journal of Dermatology

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https://www.readbyqxmd.com/read/28211055/pemphigus-a-pathomechanism-of-acantholysis
#1
REVIEW
Masutaka Furue, Takafumi Kadono
Autoantibodies to the desmosomal proteins desmoglein 1 and 3 cause pemphigus foliaceus and pemphigus vulgaris, which are characterised by keratinocyte dissociation (acantholysis) and intraepidermal blister formation. The passive transfer of pathogenic anti-desmoglein antibodies induces blisters in mice in vivo and the loss of keratinocyte adhesion in vitro. The pathogenetic mechanisms of acantholysis due to anti-desmoglein autoantibodies are not fully understood. However, recent studies have revealed that signalling-dependent and signalling-independent pathways are operative in the loss of cell adhesion...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28211049/low-dose-rituximab-and-concurrent-adjuvant-therapy-for-pemphigus-protocol-and-single-centre-long-term-review-of-nine-patients
#2
Aaron J Robinson, Mi Vu, Gary A Unglik, George A Varigos, Laura Scardamaglia
Pemphigus is an autoimmune B-cell mediated blistering disease associated with significant morbidity and mortality. Rituximab has proven effective for the treatment of steroid-refractory pemphigus, although there is controversy over the optimum dosing protocol. Additionally, effective disease control often requires long-term immunosuppression, even in disease-free periods. We present a case series of a single-centre long-term follow up of nine patients with pemphigus, treated with two 500-mg doses of rituximab separated by 14 days along with concurrent adjuvant therapy...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28211047/reasons-for-rarity-of-anal-melanocytic-naevi
#3
Eman Aljufairi, Fayek Alhilli
In the last 16 years only seven definite cases of anal melanocytic naevi have been reported in the literature. We describe three new cases, none of which were suspected clinically and were incidentally diagnosed on histological examination of haemorrhoidectomy specimens. The infrequency of these special site flexural melanocytic lesions may be related to changes in the involutionary mechanisms of the anal melanocyte proliferation. However, other factors related to the low detection rates by clinicians and pathologists need also to be considered...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28211041/a-granulomatous-conundrum-concurrent-necrobiosis-lipoidica-cutaneous-sarcoidosis-and-erythema-nodosum-in-a-nondiabetic-patient
#4
Nishant Valecha, Genevieve Bennett, Leona Yip
Necrobiosis lipoidica (NL) and cutaneous sarcoidosis are granulomatous disorders with a largely unknown aetiopathogenesis. Evidence of co-existing NL and sarcoidosis in the same patient may suggest a degree of overlap between these entities through shared granulomatous inflammatory pathways. Occasionally, one condition can mimic the other, making their distinction difficult. We report a novel case of a non-diabetic woman who presented with concurrent NL, cutaneous sarcoidosis and erythema nodosum. We discuss some of the complexities distinguishing these entities and propose that they may represent different stages of the same granulomatous process linked through yet unknown pathomechanisms...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28211037/diffuse-scarring-alopecia-in-a-female-pattern-hair-loss-distribution
#5
Bonnie Fergie, Gurpreet Khaira, Vicki Howard, Sally de Zwaan
We describe three cases of hair loss in a female pattern hair loss (FPHL) distribution with histologic features of lichen planopilaris (LPP). All patients had a history of diffuse, gradual hair loss in a Christmas tree pattern that clinically presented as FPHL on gross and dermoscopic examination. Notably, there were no characteristic clinical signs of LPP and no histologic features of FPHL. These cases are most consistent with cicatricial pattern hair loss (CPHL). This relatively new entity is similar to fibrosing alopecia in a pattern distribution (FAPD) in that they are both scarring alopecias confined to a FPHL distribution, but CPHL lacks the clinical signs of perifollicular erythema and perifollicular keratosis seen in FAPD...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28185271/melanoma-and-pregnancy
#6
REVIEW
Sarah Kym Morton, Adam Park Morton
Melanoma is the most common cancer in women during their reproductive years and kills more young Australians than any other single cancer. Care of women whose pregnancy is complicated by a diagnosis of malignancy is complex. The risk of delaying treatment to the mother, the short-term and long-term risks of premature delivery to the child, and the immediate risks to the foetus and long-term risks to the child of maternal treatment with surgery, radiotherapy or medical therapies must be considered.
February 10, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27995625/in-training-assessments-the-difficulty-is-trying-to-balance-reality-and-really-tell-the-truth
#7
Catherine E Scarff, Robert M Corderoy, Margaret Bearman
BACKGROUND: In-training assessments (ITA) aim to evaluate trainees' progress and give valuable feedback on their performance. Many factors can affect supervisors during their completion of assessments and these can influence the final results recorded. METHODS: This is the second part of a study of supervisors of the Australasian College of Dermatologists (ACD) and presents the qualitative data on their opinions of the ACD ITA process and the influences on their ITA ratings...
December 20, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27957732/chronic-vulvovaginal-candidiasis-in-patients-using-a-levonorgestrel-containing-intrauterine-device
#8
Yvonne Nguyen, Gayle Fischer
Chronic vulvovaginal candidiasis is usually responsive to therapy with oral antifungals. We present a case series of 13 patients with this condition who were also using a levonorgestrel intrauterine system (LNG-IUS). All cases responded to ongoing oral fluconazole therapy while the LNG-IUS was in situ. The LNG-IUS was removed in six patients and of these, two experienced clinical improvement with lower fluconazole dosage requirements and three experienced complete resolution of symptoms. One remains on fluconazole 100 mg daily...
December 13, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27935010/australian-dermatologists-perspective-on-skin-of-colour-results-of-a-national-survey
#9
Michelle A Rodrigues, Angelique L Ross, Steven Gilmore, Benjamin S Daniel
BACKGROUND/OBJECTIVES: This study documents the perspectives of Australian dermatologists on the adequacy of teaching and training in skin of colour (SOC), and their confidence in diagnosing and treating common medical, surgical and cosmetic issues in SOC and to gauge their desire for further training in this area. METHODS: Surveys were distributed to Australasian Dermatologists during their annual scientific meeting in Melbourne, Australia in 2014. Completed surveys from dermatologists nationwide were collected and evaluated...
December 9, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195325/acute-localised-exanthematous-pustulosis-what-are-the-diagnostic-criteria
#10
LETTER
Sylvia H Kardaun
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195324/dr-john-brenan
#11
Chris Baker
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195323/melanosis-of-the-lower-lip-subverted-by-filler-injection-a-simulator-of-early-mucosal-melanoma
#12
LETTER
Giovanni Paolino, Valentina Garelli, Dario Didona, Carmen Cantisani, Alfredo Rossi, Pietro Donati, Luca M Muscardin
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195322/generalised-pustular-psoriasis-and-neutrophilic-cholangitis-an-infrequently-reported-association-with-excellent-response-to-tumour-necrosis-factor-inhibitors
#13
LETTER
Enrique Rodríguez-Lomba, Ofelia Baniandrés, Natividad Cano, Ricardo Suárez-Fernández
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195321/phymatous-rosacea-presenting-with-leonine-facies-and-clinical-response-to-isotretinoin
#14
LETTER
Jamie S Wee, Kong Bing Tan
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195320/long-term-remission-of-persistent-adult-acne-following-very-low-dose-5%C3%A2-mg-day-isotretinoin
#15
LETTER
Marius Rademaker, John Wishart, Nick Birchall
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28195319/drug-reaction-with-eosinophilia-and-systemic-symptoms-in-metastatic-basal-cell-carcinoma-treated-with-vismodegib
#16
LETTER
Charlotte L Thomas, Malmaruha Arasaratnam, Giuliana Carlos, Andrew Parasyn, Karl W Baumgart, Pablo Fernandez-Penas, Gavin Marx
No abstract text is available yet for this article.
February 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27858975/bullous-pemphigoid-like-reaction-in-a-patient-with-metastatic-melanoma-receiving-pembrolizumab-and-previously-treated-with-ipilimumab
#17
LETTER
Anna J Lomax, Ludi Ge, Sunaina Anand, Catriona McNeil, Patricia Lowe
No abstract text is available yet for this article.
November 15, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27858977/atypical-presentation-of-livedo-racemosa-in-a-factor-v-leiden-heterozygous-positive-patient-with-pseudomonas-aeruginosa-urosepsis
#18
Jesse Johnston, Rowland Noakes, Kurt Davidson
Impairment of the protein C pathway, detectable by reduced plasma levels of activated protein C (APC), are risk factors for venous thrombosis. Activated protein C maintains clotting homeostasis by regulation of pro-coagulant factors Va and VIIIa. Both infection and the factor V Leiden mutation reduce the formation of APC from protein C in the blood. With low levels of APC, excess factors Va and VIIIa exist, increasing the risk of thrombus formation. Livedo racemosa is characterised by a striking, violaceous branch-like pattering of the skin...
November 12, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27858976/survival-rates-of-biological-therapies-for-psoriasis-treatment-in-real-world-clinical-practice-a-canadian-multicentre-retrospective-study
#19
Joseph Ec Marinas, Whan B Kim, Ali Shahbaz, Judy K Qiang, Simon Greaves, Jensen Yeung
BACKGROUND/OBJECTIVES: Data on biologic drug survival in real-world psoriasis treatment are limited. There is a need to evaluate long-term trends of biologic use outside the realm of clinical trials. METHODS: A multicentre chart review was conducted with patients' data from September 2005 to September 2014. Kaplan-Meier plot analysis was used to determine 5-year drug survival rates. A log-rank test was used to compare the rates of drug survival between the studied biologics...
November 12, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27885662/hearing-loss-in-association-with-topical-imiquimod-use-for-squamous-cell-carcinoma-in-situ-bowen-disease
#20
LETTER
Michelle Rodrigues, Sarah E Gamboni, Vincent C Cousins, Rosemary L Nixon
No abstract text is available yet for this article.
November 2016: Australasian Journal of Dermatology
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