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Australasian Journal of Dermatology

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https://www.readbyqxmd.com/read/28332321/pigmented-onychomatricoma-four-cases
#1
Jorge Ocampo-Garza, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio
Onychomatricoma (OM) presenting as a longitudinal melanonychia is a very uncommon clinical presentation with very few cases in the literature. Our aim in this article is to report four cases of pigmented OM, and describe their clinical and dermoscopic findings and the importance of the differential diagnoses, especially with melanoma.
March 23, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28332195/skin-cancer-history-sun-related-attitudes-behaviour-and-sunburn-among-renal-transplant-recipients-versus-general-population
#2
Vivian Ka Ying Leung, Suzanne Jane Dobbinson, David Josef Goodman, John Kanellis, Alvin Heong Chong
BACKGROUND/OBJECTIVES: Renal transplant recipients (RTR) have both an excessive skin cancer incidence and a high mortality rate. In Australia RTR receive extensive public education on skin cancer and many undergo further education pre/post-transplant. This study examines whether RTR have sufficiently rigorous sun protection behaviour compared with the general population. METHODS: Altogether 179 RTR from two large Melbourne hospitals involving skin clinic teams in patient care were recruited to undergo cross-sectional telephone interviews...
March 23, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28332194/high-serum-vitamin-d-level-correlates-with-better-prognostic-indicators-in-primary-melanoma-a-pilot-study
#3
Alvin Lim, Ramin Shayan, George Varigos
BACKGROUND/OBJECTIVES: Sunlight is a major risk factor for cutaneous melanoma. However, its interaction with melanoma is complex. In particular, vitamin D is a UVB-derived hormone that has been shown to have anti-cancer effects. In this retrospective pilot study we sought to determine an association between the clinicopathological features of melanoma and the patients' corresponding serum vitamin D level. METHODS: In total, 109 primary melanomas diagnosed between 2001 and 2013 were retrospectively identified from our institutional database with a corresponding 25-hydroxyvitamin D3 level estimated within 6 months of diagnosis...
March 23, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28321860/nicotinamide-for-skin-cancer-chemoprevention
#4
REVIEW
Diona L Damian
Nicotinamide (vitamin B3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population...
March 20, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28295169/characteristic-features-of-cutaneous-melanoma-in-a-dermatology-referral-centre-in-tehran-iran
#5
Kambiz Kamyab, Sheyda Kazemi, Pourya Azimi, Arghavan Azizpour, Narges Ghandi, Elham Pirooz, Pedram Noormohammadpour, Mostafa Mirshams-Shahshahani, Maryam Daneshpazhooh
BACKGROUND/OBJECTIVES: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran. METHODS: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Clinical data included age and gender of the patients at the time of diagnosis, tumour location and tumour size. Histological characteristics included Breslow thickness, Clark level and subtype of tumour...
March 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28295154/phenotypical-analysis-of-ectoenzymes-cd39-cd73-and-adenosine-receptor-2a-in-cd4-cd25-high-foxp3-regulatory-t-cells-in-psoriasis
#6
Ling Han, Hideaki Sugiyama, Qi Zhang, Kexiang Yan, Xu Fang, Thomas S McCormick, Kevin D Cooper, Qiong Huang
BACKGROUND: CD39 and CD73 are two novel cell surface markers of CD25(high) Foxp3(+) regulatory T-cells (Tregs). Concordant expression of these two ectoenzymes not only discriminate Tregs from other cell populations, but also generates pericellular adenosine, which has been reported to suppress proliferation of activated T effector (Teff) cells. Because it is currently unclear whether human ectoenzymes (CD39/CD73) are involved in the impaired suppressive activity of Tregs in psoriasis, we examined the frequencies and phenotypes of CD39/CD73-expressing Tregs and related receptor adenosine receptor 2A (A2A R) in peripheral blood of patients with different types of psoriasis...
March 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28295171/successful-use-of-bruton-s-kinase-inhibitor-ibrutinib-to-control-paraneoplastic-pemphigus-in-a-patient-with-paraneoplastic-autoimmune-multiorgan-syndrome-and-chronic-lymphocytic-leukaemia
#7
Andrew Lee, Suneet Sandhu, Louise Imlay-Gillespie, Stephen Mulligan, Stephen Shumack
We present the case of a 51-year-old man who developed paraneoplastic pemphigus (PNP) in the context of chronic lymphocytic leukemia (CLL). His CLL was successfully controlled with ibrutinib. Concurrently, there was significant improvement of his PNP, suggesting that ibrutinib may be a very useful addition to the treatment options in this potentially life-threatening autoimmune disorder.
March 13, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28295176/active-sunscreen-ingredients-in-australia
#8
REVIEW
Francis Hx Yap, Hock C Chua, Clare P Tait
UV radiation exposure is the major contributor to photocarcinogenesis and photoageing. Reducing UV radiation exposure can be achieved by using adequate sunscreen preparations. The use of sunscreen can significantly reduce the incidence of squamous cell carcinoma, actinic keratoses and invasive melanoma. In the Australian market over 900 sunscreen products are available, each with their own brand, formulation and ingredients. It can be difficult for dermatologists and consumers to determine which are the most effective and appropriate products to use...
March 10, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28294289/hypofractionated-radiotherapy-in-older-patients-with-non-melanoma-skin-cancer-less-is-better
#9
Michael Veness
Radiotherapy is a non-surgical option for patients with non-melanoma skin cancer. Lesions in middle-aged to older patients with good performance status are typically prescribed 4-5 weeks of outpatient weekday treatment. Daily radiotherapy fraction sizes of 2-3 Gy are recommended to decrease the late cutaneous consequences such as in-field hypopigmentation and telangiectasia. In elderly, often unwell patients, these concerns are less of an issue and larger fraction sizes (5-7 Gy), referred to as hypofractionation, can be delivered over a shorter time yet still achieve excellent in-field control and improve a patient's quality of life and avoid the need for surgery...
March 9, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28266706/multiple-cutaneous-leiomyomas-leading-to-discovery-of-novel-splice-mutation-in-the-fumarate-hydratase-gene-associated-with-hlrcc
#10
Rachel Yi Ping Tan, Maie Walsh, Anne Howard, Ingrid Winship
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant condition, which manifests as cutaneous leiomyomas (CL), uterine fibroids and renal cell cancer (RCC). We describe the case of a 53-year-old woman who presented with multiple CL with a novel heterozygous canonical splice site mutation in intron 9 of the fumarate hydratase (FH) gene IVS 9-1 G>C (NM_000143.3:c 1391-1 G>C) that was not detected on initial screening of a mutation hotspot but was picked up on sequencing the remaining exons and splice site junctions...
March 7, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28266704/the-efficacy-of-australian-essential-oils-for-the-treatment-of-head-lice-infestation-in-children-a-randomised-controlled-trial
#11
Kerryn A Greive, Tanya M Barnes
BACKGROUND: The increase in resistance of head lice to neurotoxic pediculicides and public concern over their safety has led to an increase in alternative treatments, many of which are poorly researched or even untested. METHODS: A multicentre, randomised, assessor-blind, parallel-group trial (Trial 1) was conducted to compare the safety and efficacy of a head lice treatment containing Australian eucalyptus oil and Leptospermum petersonii (EO/LP solution; applied thrice with 7-day intervals between applications) with a neurotoxic treatment containing pyrethrins and piperonyl butoxide (P/PB mousse; applied twice with a 7-day interval) in children...
March 7, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28266703/changes-to-infant-feeding-guidelines-relevance-to-dermatologists
#12
REVIEW
Celestine C Wong, Katrina J Allen, David Orchard
The newly revised Australian Infant Feeding Guidelines recommends that all infants, including those at high risk of allergy, be introduced foods traditionally considered allergenic (such as peanut butter, dairy, wheat and egg) within the first year of life. High-risk infants are those with early onset eczema (<3-months old) or with moderate to severe eczema not responding to treatment (<6-months old). Eczema can also represent a symptom of allergy presentation and the recommended introduction of some foods in this group may lead to allergic reactions at home...
March 7, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28251621/burden-of-human-scabies-in-sub-saharan-african-prisons-evidence-from-the-west-region-of-cameroon
#13
Emmanuel Armand Kouotou, Jobert Richie Nansseu, Abdoulaye Sangare, Léonnelle-Lynda Moguieu Bogne, Isidore Sieleunou, Hugues Adegbidi, Joël Tameyi Tatsa, Roger Moyou Somo
BACKGROUND/OBJECTIVES: There is little data on the profile and magnitude of scabies in sub-Saharan African prisons. The present study aimed to assess the prevalence and determinants of scabies in prisons of the west region of Cameroon. METHODS: We conducted a cross-sectional study from March to August 2014, and consecutively recruited volunteer detainees of three randomly selected prisons in the West Region of Cameroon. The diagnosis was based on clinical findings after assessment by two experienced and well-trained dermatologists...
March 1, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28251611/consensus-statement-for-the-treatment-of-infantile-haemangiomas-with-propranolol
#14
Sarah L Smithson, Marius Rademaker, Susan Adams, Stuart Bade, Philip Bekhor, Samantha Davidson, Amanda Dore, Catherine Drummond, Gayle Fischer, Alexander Gin, Claire Grills, Anne Halbert, Zerina Lokmic, Emma McCahon, Vanessa A Morgan, Dedee F Murrell, David Orchard, Anthony Penington, Diana Purvis, John Relic, Susan Robertson, Aaron J Robinson, Laura Scardamaglia, John Su, Swee Tan, Orli Wargon, Lachlan Warren, Li-Chuen Wong, Tania Zappala, Roderic Phillips
Although most infantile haemangiomas do not require treatment due to a natural history of spontaneous involution, some require early intervention. The Australasian Vascular Anomalies Network and the Australasian Paediatric Dermatology Network have developed a consensus statement for the treatment of infantile haemangiomas with oral propranolol. Infants with haemangiomas that are life threatening, at risk of ulceration, or at risk of causing a significant functional impairment, psychological impact or physical deformity should be treated early with oral propranolol...
March 1, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28247410/congenital-erosive-and-vesicular-dermatosis-with-reticulated-supple-scarring
#15
Vincent Wong, Gayle Fischer
Congenital erosive and vesicular dermatosis with reticulated supple scarring is a rare cutaneous disorder of unknown aetiology first described by Cohen and colleagues in 1985. It classically presents in the neonate as erosions and vesicles that heal within the first months of life, with supple scarring of a reticulated pattern. Along with a review of the literature, this article presents two atypical cases of congenital erosive and vesicular dermatosis with reticulated supple scarring. Patient one presented with neither erosions nor vesicles at birth, yet continued to experience sporadic blistering at the age of 15 months and patient two is the second documented case to develop congenital erosive and vesicular dermatosis after birth...
February 28, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28247404/smartphone-use-in-dermatology-for-clinical-photography-and-consultation-current-practice-and-the-law
#16
Lisa M Abbott, Roger S Magnusson, Emma Gibbs, Saxon D Smith
BACKGROUND: Smartphones are rapidly changing the way doctors capture and communicate clinical information, particularly in highly visual specialties such as dermatology. An understanding of how and why smartphones are currently used in clinical practice is critical in order to evaluate professional and legal risks, and to formulate policies that enable safe use of mobile technologies for the maximal benefit of practitioners and patients. METHODS: Australian dermatologists and dermatology trainees were surveyed on their current practices relating to clinical smartphone use...
February 28, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28244587/scar-outcomes-in-dermatological-surgery
#17
Burcu Kim, Melissa Sgarioto, Daniel Hewitt, Robert Paver, Julia Norman, Pablo Fernandez-Penas
BACKGROUND/OBJECTIVES: Significant functional impairment and psychological burden may result from poor scar quality and its impact on patient's quality of life has been well-established. It is important to identify measures to reduce the risk of surgical complications. METHOD: 212 patients undergoing dermatological surgery were recruited from March 2011 to February 2014. Their age, sex, surgical site, closure type, defect size (length and width), scar length, number of deep sutures, suture type and size were recorded...
February 28, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28240347/efficacy-of-smartphone-applications-in-high-risk-pigmented-lesions
#18
Alexander Ngoo, Anna Finnane, Erin McMeniman, Jean-Marie Tan, Monika Janda, H Peter Soyer
BACKGROUND/OBJECTIVES: Melanoma apps are smartphone applications that assess risk of pigmented lesions using a smartphone camera and underlying algorithm. We aimed to assess the capability of melanoma smartphone applications (apps) in making clinical decisions about risk, compared with lesion assessment by specialist trained dermatologists. METHODS: A prospective study of 3 melanoma apps was conducted between 2015 and 2016, recruiting 30 patients with 57 pigmented lesions...
February 27, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28240345/upregulated-expression-of-la-ribonucleoprotein-domain-family-member-6-and-collagen-type-i-gene-following-water-filtered-broad-spectrum-near-infrared-irradiation-in-a-3-dimensional-human-epidermal-tissue-culture-model-as-revealed-by-microarray-analysis
#19
Yohei Tanaka, Jun Nakayama
BACKGROUND/OBJECTIVES: Water-filtered broad-spectrum near-infrared irradiation can induce various biological effects, as our previous clinical, histological, and biochemical investigations have shown. However, few studies that examined the changes thus induced in gene expression. The aim was to investigate the changes in gene expression in a 3-dimensional reconstructed epidermal tissue culture exposed to water-filtered broad-spectrum near-infrared irradiation. METHODS: DNA microarray and quantitative real-time polymerase chain reaction (PCR) analysis was used to assess gene expression levels in a 3-dimensional reconstructed epidermal model composed of normal human epidermal cells exposed to water-filtered broad-spectrum near-infrared irradiation...
February 27, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28240342/acne-necrotica-necrotizing-lymphocytic-folliculitis-an-enigmatic-and-under-recognised-dermatosis
#20
Lucy K Pitney, Blake O'Brien, Michael J Pitney
Acne necrotica is a disorder of adults of obscure aetiology, featuring repeated cropping of inflammatory papulonodules which rapidly necrotise, leaving varying degrees of superficial scarring with pathological features in early lesions of a necrotising lymphocytic folliculitis. A perceived diminishing interest in this entity in recent years prompted a prospective study of patients presenting to a dermatology practice over a 3-year period to reassess the prevalence of this disorder in general dermatological patients, leading to the identification of 47 patients (35 female) with features of acne necrotica, with histopathology undertaken in atypical cases...
February 27, 2017: Australasian Journal of Dermatology
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