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Oncology

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https://www.readbyqxmd.com/read/28334713/pulsed-dose-rate-brachytherapy-for-the-treatment-of-endometrial-cancer
#1
Francesca De Felice, Rossella Caiazzo, Ilaria Benevento, Daniela Musio, Filippo Rubini, Vincenzo Tombolini
Endometrial cancer (EC) is the most frequent gynecologic malignancy. The aim of this review is to outline clinical practice recommendations, to suggest a technical solution, and to advise doses selection for pulsed-dose rate (PDR) brachytherapy in EC. Electronic bibliographic databases, including PubMed, clinicaltrials.gov, and the American Society of Clinical Oncology (ASCO) Meeting Library, were searched for articles in English. Clinical guidelines and systematic reviews were also considered. The appropriate therapeutic approach should consider risk factors for tumor relapse and PDR brachytherapy and have a convincing role in this multidisciplinary scenario...
March 24, 2017: Oncology
https://www.readbyqxmd.com/read/28334705/are-there-breast-cancer-patients-with-node-negative-small-tumours-who-do-not-benefit-from-adjuvant-systemic-therapy
#2
Tanja Stüber, Igor Novopashenny, Joachim Diessner, Catharina Bartmann, Roland Stein, Mathias Krockenberger, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Achim Wöckel, Manfred Wischnewsky
OBJECTIVE: To identify subgroups of patients with pT1 pN0 breast cancer (BC) who might not profit from adjuvant systemic therapy (AST). METHODS: Data of 3,774 pT1 pN0 BC patients from 17 certified BC centres within the BRENDA study group were collected between 1992 and 2008 and retrospectively analysed. Uni- and multivariate analyses were performed using Kaplan-Meier methods and Cox regression models. RESULTS: 279 (7.4%) of the pT1 pN0 BC patients were T1a, 944 (25...
March 24, 2017: Oncology
https://www.readbyqxmd.com/read/28329738/transarterial-chemo-embolization-for-liver-metastases-in-patients-with-neuroendocrine-tumors
#3
Hiroyuki Okuyama, Masafumi Ikeda, Hideaki Takahashi, Izumi Ohno, Yusuke Hashimoto, Shuichi Mitsunaga, Yasunari Sakamoto, Shunsuke Kondo, Chigusa Morizane, Hideki Ueno, Tatsushi Kobayashi, Yasuaki Arai, Takuji Okusaka
OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of transarterial (chemo)embolization [TA(C)E] for the control of liver metastasis in patients with neuroendocrine tumors (NETs). METHODS: In this retrospective study, we enrolled 43 patients with metastatic NETs who had been treated with TA(C)E between December 1999 and June 2013 at the National Cancer Center Hospital, Tokyo or the National Cancer Center Hospital East, Kashiwa. We assessed tumor response, time to treatment failure (TTF), overall survival (OS), and frequency of adverse events in these patients, and attempted to identify predictors of TTF...
March 23, 2017: Oncology
https://www.readbyqxmd.com/read/28278499/recurrence-and-risk-factors-for-relapse-in-patients-with-non-small-cell-lung-cancer-treated-by-surgery-with-curative-intent
#4
Cristiana Cruz, Margarida Afonso, Bárbara Oliveiros, Alice Pêgo
INTRODUCTION: Surgery remains the potentially curative treatment for early-stage non-small cell lung cancer (NSCLC). Despite this, tumor recurrence is the most common cause of treatment failure after surgery. METHODS: Data were collected retrospectively from clinical files of patients who underwent lung surgery for NSCLC from January 2008 to December 2012 in a University Hospital. Demographic data, tumor characteristics, type of surgery and recurrence were recorded...
March 10, 2017: Oncology
https://www.readbyqxmd.com/read/28259891/the-role-of-couples-attachment-styles-in-patients-adjustment-to-cancer
#5
Rossella De Luca, Patrizia Dorangricchia, Laura Salerno, Gianluca Lo Coco, Giuseppe Cicero
OBJECTIVE: This study aimed to understand how psychological variables and attachment styles can contribute to improve effective and functional adjustment to the disease and promote better psychological well-being. METHODS: A total of 176 participants (88 couples) took part in this research. One member of each couple attended surgery centers at the Oncology Department of the University Hospital of Palermo. Each participant had filled in 5 questionnaires assessing the variables couple relationships, quality of life, anxiety, depression, and psychosocial adjustment to illness...
March 4, 2017: Oncology
https://www.readbyqxmd.com/read/28259870/c-rel-promotes-invasion-of-choriocarcinoma-cells-via-pi3k-akt-signaling
#6
Yoko Sekiya, Eiko Yamamoto, Kaoru Niimi, Kimihiro Nishino, Kenichi Nakamura, Tomomi Kotani, Hiroaki Kajiyama, Kiyosumi Shibata, Fumitaka Kikkawa
OBJECTIVE: Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. METHODS: We examined the expression of NF-κB family proteins in normal placenta and hydatidiform mole tissues as well as extravillous trophoblast (EVT) and choriocarcinoma cell lines by Western blot and immunohistochemistry...
March 4, 2017: Oncology
https://www.readbyqxmd.com/read/28259868/small-foci-of-serous-component-as-a-predictor-of-recurrence-and-prognosis-for-stage-ia-endometrial-carcinomas
#7
Morikazu Miyamoto, Masashi Takano, Hitoshi Tsuda, Hiroaki Soyama, Tadashi Aoyama, Hiroki Ishibashi, Kento Kato, Hideki Iwahashi, Hiroko Matuura, Tomoyuki Yoshikawa, Ayako Suzuki, Junko Hirata, Kenichi Furuya
OBJECTIVE: Most of the endometrial carcinomas are detected in early stages and have a better prognosis; however, predictive factors for recurrence have not been determined. METHODS: Patients with grade 1 endometrioid carcinoma (EG1) according to the 2014 WHO criteria at FIGO 2009 stage IA that were identified through scanning medical charts were included, and we assessed whether the presence of uterine serous carcinoma (SC) component which comprised less than 5% of the total volume using the ovarian two-tiered grading system could be a recurrent risk factor in these patients...
March 4, 2017: Oncology
https://www.readbyqxmd.com/read/28249280/perioperative-chemotherapy-in-elderly-patients-with-locally-advanced-adenocarcinoma-of-the-stomach-and-the-esophagogastric-junction-a-retrospective-cohort-analysis-of-toxicity-and-efficacy-at-the-national-center-for-tumor-diseases-heidelberg
#8
Georg Martin Haag, Anne Byl, Dirk Jäger, Anne Katrin Berger
OBJECTIVE: Esophagogastric cancer occurs more frequently in older patients, but these are underrepresented in clinical studies establishing the current treatment standards for perioperative chemotherapy in locally advanced disease. This leads to uncertainty regarding the treatment of older patients with potentially toxic but active regimens. METHODS: Using a prospectively generated database, we analyzed 63 patients aged ≥70 years undergoing perioperative chemotherapy for locally advanced esophagogastric cancer...
March 2, 2017: Oncology
https://www.readbyqxmd.com/read/28245484/impact-of-hepatitis-c-virus-eradication-on-the-clinical-outcome-of-patients-with-hepatitis-c-virus-related-advanced-hepatocellular-carcinoma-treated-with-sorafenib
#9
Tomokazu Kawaoka, Hiroshi Aikata, Yuji Teraoka, Yuki Inagaki, Fumi Honda, Masahiro Hatooka, Kei Morio, Reona Morio, Tomoki Kobayashi, Yuko Nagaoki, Takashi Nakahara, Akira Hiramatsu, Masataka Tsuge, Michio Imamura, Yoshiiku Kawakami, Kazuaki Chayama
OBJECTIVE: To evaluate the impact of hepatitis C virus (HCV) eradication on the clinical outcome of patients with HCV-related advanced hepatocellular carcinoma (HCC) treated with sorafenib. METHODS: A total of 58 HCV-related advanced HCC patients with Child-Pugh grade A disease who were treated with sorafenib were enrolled in this retrospective cohort study. Of these, 27 patients were HCV RNA negative as a result of previous antiviral therapy (sustained viral response [SVR] group), while the remaining 31 were HCV RNA positive (non-SVR group)...
March 1, 2017: Oncology
https://www.readbyqxmd.com/read/28222447/impact-of-pd-l1-expression-in-patients-with-surgically-resected-non-small-cell-lung-cancer
#10
Satoshi Igawa, Yuichi Sato, Shinichiro Ryuge, Masaaki Ichinoe, Ken Katono, Yasuhiro Hiyoshi, Sakiko Otani, Ryo Nagashio, Hiroyasu Nakashima, Masato Katagiri, Jiichiro Sasaki, Yoshiki Murakumo, Yukitoshi Satoh, Noriyuki Masuda
BACKGROUND: Immunotherapy can become a crucial therapeutic option to improve the prognosis of patients with non-small-cell lung cancer (NSCLC). Here, we evaluated the impact of programmed cell death ligand-1 (PD-L1) expression in surgically resected NSCLCs. METHODS: We estimated PD-L1 expression in 229 consecutive NSCLC specimens using rabbit polyclonal antibodies to human PD-L1 in a SP263 immunohistochemical assay and evaluated PD-L1 expression for potential associations with clinicopathological parameters and survival time...
February 22, 2017: Oncology
https://www.readbyqxmd.com/read/28219073/relationship-between-pulmonary-adverse-events-and-everolimus-exposure-in-japanese-and-non-japanese-patients-a-meta-analysis-of-oncology-trials
#11
Shinzaburo Noguchi, Nobuo Shinohara, Tetsuhide Ito, Atsushi Ohtsu, Alain Ravaud, Guy Jerusalem, Nobutsugu Ohno, Jorge Gallo, Emmanuel Bouillaud, Jenna Fan, Norio Nonomura
AIMS: This meta-analysis explores the relationship between the everolimus minimum (Cmin) and maximum (Cmax) exposure and the risk for pulmonary adverse events (AEs) in Japanese versus non-Japanese patients. METHODS: Patient-level data from patients treated with daily everolimus in advanced solid tumor trials were evaluated using a Cox regression model, stratified by cancer type or treatment arm, with log-transformed time-averaged Cmin or Cmax as a time-varying covariate...
February 21, 2017: Oncology
https://www.readbyqxmd.com/read/28208153/outcome-of-patients-with-renal-cell-carcinoma-and-multiple-glandular-metastases-treated-with-targeted-agents
#12
Paolo Grassi, Ludovic Doucet, Palma Giglione, Viktor Grünwald, Bohuslav Melichar, Luca Galli, Ugo De Giorgi, Roberto Sabbatini, Cinzia Ortega, Matteo Santoni, Aristotelis Bamias, Elena Verzoni, Lisa Derosa, Hana Studentova, Luca Porcu, Filippo De Braud, Camillo Porta, Giuseppe Procopio
PURPOSE: Pancreatic metastases (PM) from renal cell carcinoma (RCC) have been associated with long-term survival. The aim of this study was to evaluate the outcome of RCC patients with multiple glandular metastases (MGM) treated with targeted therapies (TTs). METHODS: Sixty-four MGM patients treated between 1993 and 2014 were retrospectively identified from a database of 274 RCC patients with PM from 11 European centers. The survival of MGM patients was compared with that of both patients with PM only and a cohort of 325 RCC patients with non-GM (control group) treated with TTs...
February 17, 2017: Oncology
https://www.readbyqxmd.com/read/28196364/technetium-99m-or-cy7-labeled-rituximab-as-an-imaging-agent-for-non-hodgkin-lymphoma
#13
Ximena Camacho, Camila Longo Machado, María Fernanda García, Juan Pablo Gambini, Agustina Banchero, Marcelo Fernández, Natalia Oddone, Daniela Bertolini Zanatta, Carolina Rosal, Carlos Alberto Buchpiguel, Roger Chammas, Eloisa Riva, Pablo Cabral
INTRODUCTION: Rituximab was the first monoclonal antibody approved for the treatment of B-cell non-Hodgkin lymphoma (NHL) expressing CD20 antigen. This antibody has also the potential to be used as a specific fluorescent and radiolabel agent for targeting NHL. OBJECTIVE: To radiolabel rituximab with technetium-99m (99mTc) or Cy7 and evaluate both probes as potential imaging agents for NHL. METHODS: Rituximab was derivatized with the trifluoroacetyl hydrazino protected form of succinimidyl ester of HYNIC and radiolabeled with 99mTc...
February 15, 2017: Oncology
https://www.readbyqxmd.com/read/28178692/monitoring-of-serum-carcinoembryonic-antigen-levels-after-curative-resection-of-colon-cancer-cutoff-values-determined-according-to-preoperative-levels-enhance-the-diagnostic-accuracy-for-recurrence
#14
Gota Saito, Sotaro Sadahiro, Hiroko Kamata, Hiroshi Miyakita, Kazutake Okada, Akira Tanaka, Toshiyuki Suzuki
OBJECTIVES: Serum carcinoembryonic antigen (CEA) has been widely used for postoperative surveillance for colorectal cancer. However, serum CEA has a poor diagnostic accuracy for detecting recurrence. We tested the hypothesis that determining cutoff values according to the preoperative serum CEA levels would enhance the diagnostic accuracy. METHODS: Serum CEA was measured before and 1-6 months after surgery in 783 patients with curatively resected colon cancer from 2005 through 2013...
February 9, 2017: Oncology
https://www.readbyqxmd.com/read/28171863/a-retrospective-study-on-the-onset-of-menopause-after-chemotherapy-analysis-of-data-extracted-from-the-jean-perrin-comprehensive-cancer-center-database-concerning-345-young-breast-cancer-patients-diagnosed-between-1994-and-2012
#15
Joyce Dohou, Marie-Ange Mouret-Reynier, Fabrice Kwiatkowski, Marie Arbre, Pauline Herviou, Mélanie Pouget, Catherine Abrial, Frédérique Penault-Llorca
OBJECTIVE: Young breast cancer (BC) patients receiving chemotherapy are at risk of chemotherapy-induced menopause (CIM). We sought to define the incidence rate of premature menopause after chemotherapy and to retrospectively investigate factors related to the onset of menopause. METHODS: We identified BC patients who had received chemotherapy at the Cancer Center (Centre Jean-Perrin). We selected premenopausal women aged between 18 and 50 years at the moment of diagnosis who received chemotherapy between 1994 and 2012...
February 8, 2017: Oncology
https://www.readbyqxmd.com/read/28152526/egfr-inhibitors-in-patients-with-advanced-squamous-cell-anal-carcinomas-a-single-institution-experience
#16
Dae Won Kim, Jennifer Byer, Nishi Kothari, Amit Mahipal, Yound Doo Chang, Richard D Kim
BACKGROUND: Although squamous cell anal carcinomas are relatively rare, their incidence has been increasing steadily. Because of the limited data, treatment of metastatic disease is a major therapeutic challenge. In this study, we report the safety and efficacy of epidermal growth factor receptor (EGFR) inhibitors in patients with advanced squamous cell anal carcinomas. METHOD: A retrospective analysis was conducted using the Moffitt Cancer Tumor Registry from January 2009 to January 2014...
February 3, 2017: Oncology
https://www.readbyqxmd.com/read/28142146/incidence-of-histologically-proven-pelvic-and-para-aortic-lymph-node-metastases-and-rate-of-upstaging-in-patients-with-locally-advanced-cervical-cancer-results-of-a-prospective-randomized-trial
#17
Audrey Tieko Tsunoda, Simone Marnitz, Joao Soares Nunes, Carlos Eduardo Mattos de Cunha Andrade, Christovam Scapulatempo Neto, Jens-Uwe Blohmer, Jörg Herrmann, Ligia Maria Kerr, Peter Martus, Achim Schneider, Giovanni Favero, Christhardt Köhler
BACKGROUND: Surgical staging is associated with a significant rate of upstaging compared to clinical/radiological staging in patients with locally advanced cervical cancer. OBJECTIVE: To analyze the stage-specific percentage of pelvic and para-aortic lymph node metastases and the upstaging ratio in a prospective randomized trial (Uterus-11). METHODS: FIGO stage IIB-IVA cervical cancer patients were randomized to surgical staging (arm A) or to clinical staging and primary chemoradiation (arm B)...
February 1, 2017: Oncology
https://www.readbyqxmd.com/read/28142137/efficacy-of-second-line-bevacizumab-containing-chemotherapy-for-patients-with-metastatic-colorectal-cancer-following-first-line-treatment-with-an-anti-epidermal-growth-factor-receptor-antibody
#18
Hiroko Hasegawa, Hiroya Taniguchi, Seiichiro Mitani, Toshiki Masuishi, Azusa Komori, Yukiya Narita, Shigenori Kadowaki, Takashi Ura, Masashi Ando, Yasushi Yatabe, Kei Muro
OBJECTIVE: Anti-epidermal growth factor receptor (EGFR) antibodies and bevacizumab are commonly used, sequentially, as palliative chemotherapies for patients with metastatic colorectal cancer. However, little is known about the efficacy of second-line treatments containing bevacizumab after first-line treatment with an anti-EGFR antibody. METHODS: We retrospectively reviewed 128 patients who received second-line bevacizumab-containing chemotherapy and evaluated the effect of prior use of anti-EGFR antibody on the efficacy of the second-line treatment...
February 1, 2017: Oncology
https://www.readbyqxmd.com/read/28132057/is-beta-blocker-use-beneficial-in-breast-cancer-a-meta-analysis
#19
Hyun Yul Kim, Youn Joo Jung, Sang Hyup Lee, Hyuk Jae Jung, Kyoungjune Pak
OBJECTIVE: Preclinical studies have proved that beta-blocking agents inhibit several pathways for breast cancer progression and metastasis. We aimed to evaluate the association between beta-blocker use and prognosis of breast cancer. METHODS: A systematic search for studies from MEDLINE and EMBASE (inception to March 2014) was performed using the keywords "breast cancer" and "beta-blocker." In 2 groups of breast cancer patients (beta-blocker users and non-beta-blocker users), overall deaths (ODs), cancer-specific deaths (CSDs), and recurrences were compared...
January 28, 2017: Oncology
https://www.readbyqxmd.com/read/28110330/prognostic-advantage-of-docetaxel-cisplatin-5-fluorouracil-neoadjuvant-chemotherapy-in-clinical-stage-ii-iii-esophageal-squamous-cell-carcinoma-due-to-excellent-control-of-preoperative-disease-and-postoperative-lymph-node-recurrence
#20
Keishi Yamashita, Kei Hosoda, Hiromitsu Moriya, Chikatoshi Katada, Mitsuhiro Sugawara, Hiroaki Mieno, Shoko Komori, Natsuya Katada, Masahiko Watanabe
BACKGROUND: Neoadjuvant chemotherapy (NAC) has become prevalent in esophageal squamous cell carcinoma (ESCC), but its long-term prognostic advantages remain unclear. The latest prognostic outcomes in clinical Stage (cStage) II/III ESCC with NAC were herein elucidated. PATIENTS AND METHODS: NAC prior to curative treatment was done in 115 cStage II/III ESCC patients with either cisplatin (CDDP)/5-fluorouracil (5-FU; CF) (n = 41) or docetaxel/CDDP/5-FU (DCF) NAC (n = 74) between 2007 and 2013...
January 21, 2017: Oncology
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