Peter A Kavsak, Lorna Clark, Saranya Arnoldo, Amy Lou, Jennifer L Shea, Shaun Eintracht, Andrew W Lyon, Vipin Bhayana, Laurel Thorlacius, Joshua E Raizman, Albert Tsui, Rose Djiana, Michael Chen, Yun Huang, Ali Haider, Ronald A Booth, Chris McCudden, Paul M Yip, Daniel Beriault, David Blank, Angela W S Fung, Jennifer Taher, Julie St-Cyr, Sameer Sharif, Emilie Belley-Cote, Beth L Abramson, Steven M Friedman, Jafna L Cox, Marco L A Sivilotti, Annabel Chen-Tournoux, Jesse McLaren, Susanna Mak, Venkatesh Thiruganasambandamoorthy, Frank Scheuermeyer, Karin H Humphries, Andrew Worster, Dennis Ko, Kristin M Aakre, Nicholas L Mills, Allan S Jaffe
BACKGROUND: An analytical benchmark for high-sensitivity cardiac troponin (hs-cTn) assays is to achieve a coefficient of variation (CV) of ≤ 10.0 % at the 99th percentile upper reference limit (URL) used for the diagnosis of myocardial infarction. Few prospective multicenter studies have evaluated assay imprecision and none have determined precision at the female URL which is lower than the male URL for all cardiac troponin assays. METHODS: Human serum and plasma matrix samples were constructed to yield hs-cTn concentrations near the female URLs for the Abbott, Beckman, Roche, and Siemens hs-cTn assays...
February 13, 2024: Clinical Biochemistry