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Clinical Biochemistry

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https://www.readbyqxmd.com/read/29162471/reply-to-letter-by-trupp-et-al
#1
LETTER
Fred S Apple, Amy K Saenger, Ian L Gunsolus, Sara A Love, Allan S Jaffe
No abstract text is available yet for this article.
November 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29157655/roles-of-high-apolipoprotein-e-blood-levels-and-hdl-in-development-of-familial-dysbetalipoproteinemia-in-%C3%AE%C2%B52%C3%AE%C2%B52-subjects
#2
James P Corsetti, Charles E Sparks, Stephan J L Bakker, Eke G Gruppen, Robin P F Dullaart
OBJECTIVE: Familial dysbetalipoproteinemia (FD) or Type III hyperlipoproteinemia is a mixed hyperlipidemia closely associated with the ε2ε2 genotype of the common APOE polymorphism although not all homozygotes progress to FD. Unlike the polymorphism, few studies explore effects of apolipoprotein E (apoE) blood levels on FD development. Likewise, despite the known apoE2 lipoprotein binding preference for high-density lipoprotein (HDL); little work exists exploring HDL in FD. Accordingly, this study was undertaken to investigate potential roles in FD development for apoE and HDL...
November 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29154955/a-global-call-to-arms-for-clinical-laboratories-harmonised-quantification-and-reporting-of-monoclonal-proteins
#3
EDITORIAL
Jillian R Tate, David F Keren, Peter Mollee
No abstract text is available yet for this article.
November 15, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29132766/neutrophil-to-lymphocyte-ratio-predict-mortality-and-major-adverse-cardiac-events-in-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#4
Chao-Hui Dong, Zhang-Min Wang, Si-Yu Chen
OBJECTIVES: Neutrophil to lymphocyte ratio (NLR) might be associated with the mortality or major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients. We performed a meta-analysis to evaluate the correlation between NLR and mortality/MACEs in ACS. METHODS: We assessed clinical trials through Pubmed, EMBASE, the Cochrane Library and Web of science in investigating the association between NLR and mortality/MACEs in ACS patients up to August 15, 2017...
November 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29129627/serum-reference-interval-of-architect-alpha-fetoprotein-in-healthy-chinese-han-adults-sub-analysis-of-a-prospective-multi-center-study
#5
Cunling Yan, Jia Yang, Lianhua Wei, Jian Hu, Jiaqi Song, Xiaoqin Wang, Ruilin Han, Ying Huang, Wei Zhang, Andrew Soh, Agim Beshiri, Zhuping Fan, Yijie Zheng, Wei Chen
OBJECTIVES: Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). METHODS: This analysis included a total of 530 participants (41...
November 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29129626/clinical-significance-of-the-serum-biomarker-index-detection-in-children-with-henoch-schonlein-purpura
#6
Narangerel Purevdorj, Yun Mu, Yajun Gu, Fang Zheng, Ran Wang, Jinwei Yu, Xuguo Sun
OBJECTIVE: To explore a panel of serum biomarkers for laboratory diagnosis of pediatric Henoch-Schönlein purpura (HSP). METHODS: The blood white blood cells (WBC) and serum levels of serum amyloid A (SAA), interleukin 6 (IL-6), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin E (IgE), C-reactive protein (CRP), complement component 3 (C3), complement component 4 (C4), and ASO (anti-streptolysin O) were detected in 127 patients with Henoch-Schonlein purpura (HSP), 110 cases of septicemia patients, and 121 healthy volunteers...
November 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29129625/comparison-of-fasting-and-non-fasting-lipid-profiles-in-a-large-cohort-of-patients-presenting-at-a-community-hospital
#7
Louis-Jacques Cartier, Charlene Collins, Mathieu Lagace, Pierre Douville
OBJECTIVE: To compare the fasting and non-fasting lipid profile including ApoB in a cohort of patients from a community setting. Our purpose was to determine the proportion of results that could be explained by the known biological variation in the fasting state and to examine the additional impact of non-fasting on these same lipid parameters. METHODS: 1093 adult outpatients with fasting lipid requests were recruited from February to September 2016 at the blood collection sites of the Moncton Hospital...
November 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29107010/combining-high-sensitivity-cardiac-troponin-and-b-type-natriuretic-peptide-in-the-detection-of-inducible-myocardial-ischemia
#8
Christian Puelacher, Max Wagener, Ursina Honegger, Mustafa Assadian, Nicolas Schaerli, Deborah Mueller, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Karin Wildi, Zaid Sabti, Lorraine Sazgary, Patrick Badertscher, Jeanne du Fay de Lavallaz, Stella Marbot, Christoph Kaiser, Damian Wild, Michael J Zellweger, Tobias Reichlin, Christian Mueller
BACKGROUND: Single biomarker approaches provide only moderate accuracy in the non-invasive detection of exercise-induced myocardial ischemia. We therefore assessed the combination of the two most promising single biomarkers: high-sensitivity cardiac troponin I (hs-cTnI) and B-type natriuretic peptide (BNP). METHODS: Consecutive patients with suspected myocardial ischemia referred to stress myocardial perfusion single-photon emission tomography imaging (MPI) were enrolled...
November 8, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29122642/evaluation-of-the-roche%C3%A2-elecsys-and-the-diasorin%C3%A2-liaison-s100-kits-in-the-management-of-mild-head-injury-in-the-emergency-room
#9
Quentin Delefortrie, François Lejeune, Benjamin Kerzmann, Raphaël Levy, Jean-François Adam, Thierry Sottiaux, Alexandre Grimmelprez, Patrick Vankerkhoven, Said Hachimi-Idrissi
INTRODUCTION: The aim of this single-center prospective study is to compare two commercially available S100ß kits (the Roche® Elecsys and the Diasorin® Liaison S100 kits) in terms of analytical and clinical performances in a population admitted in the emergency room for mild traumatic brain injury (mTBI). MATERIAL AND METHOD: 110 patients were enrolled from September 2014 to May 2015. Blood sample draws were performed within 3h after head trauma and the study population was split into pediatric and adult subpopulations (>18years of age)...
November 7, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29122643/parathyroid-hormone-related-protein-concentration-in-human-serum-and-csf-correlates-with-age
#10
Mark M Kushnir, Lisa K Peterson, Frederick G Strathmann
BACKGROUND: Parathyroid Hormone-Related Protein (PTHrP) is involved in intracellular calcium (Ca) regulation, and has been demonstrated to participate in regulation of Ca in brain cells, activation of neurons, and modulation of pain. However, there are conflicting reports regarding the presence of PTHrP in CSF. DESIGN AND METHODS: PTHrP and Ca were quantified in paired CSF and serum samples using mass spectrometry-based methods. Associations between PTHrP and Ca concentrations with age, sex and concentrations of nine CSF diagnostic markers in a set of 140 paired serum and CSF patient samples were evaluated...
November 6, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29113784/sex-specific-99th-percentiles-derived-from-the-aacc-universal-sample-bank-for-the-roche-gen-5-ctnt-assay-comorbidities-and-statistical-methods-influence-derivation-of-reference-limits
#11
LETTER
Robin J Trupp, Gesa Albert, Andre Ziegler
No abstract text is available yet for this article.
November 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29108727/reproducibility-of-serum-oxysterols-and-lanosterol-among-postmenopausal-women-results-from-epic-heidelberg
#12
Da-Lin Lu, Disorn Sookthai, Charlotte Le Cornet, Verena A Katzke, Theron S Johnson, Rudolf Kaaks, Renée T Fortner
BACKGROUND: Circulating oxysterols have been proposed as biological markers of disease risk. However, within-person reproducibility of circulating oxysterols over time is not well established. METHODS: We evaluated the one-year reproducibility of 11 oxysterols and lanosterol among 30 postmenopausal women with repeat blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) - Heidelberg, Germany cohort. Liquid chromatography-mass spectrometry (LC/MS) was performed to quantify serum concentrations of 22R-hydroxycholesterol, 2β-hydroxycholesterol, 24S-hydroxycholesterol, 27-hydroxycholesterol, 22S-hydroxycholeterol, 24,2β-epoxycholesterol, 5α,6β-dihydroxycholestanol, 7α-hydroxycholesterol, 5β,6β-epoxycholesterol, 5α,6α-epoxycholesterol, 24-dihydrolanosterol, and lanosterol...
November 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29103929/macro-pro-b-type-natriuretic-peptide-probnp-and-hidden-macro-n-terminal-probnp-case-report
#13
Yasuaki Nakagawa, Toshio Nishikimi, Hiroshi Sakai, Seiko Ohno, Hideyuki Kinoshita, Hideaki Inazumi, Kenji Moriuchi, Koichiro Kuwahara, Minoru Horie, Takeshi Kimura
B-type natriuretic peptide (BNP) is a cardiac hormone widely used as a biomarker for heart failure. Here, we present the first report of extremely high levels of immunoreactive BNP caused by formation of macro-proBNP. A 70-year-old woman with left ventricular hypertrophy and normal systolic function presented with extremely high plasma levels of BNP (35,374pg/ml) and N-terminal proBNP (NT-proBNP; 30,600pg/ml). Our recently developed proBNP immunoassay showed that nearly 100% of her immunoreactive BNP was proBNP...
November 2, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29111449/editorial-on-laboratory-diagnosis-and-management-of-plasma-cell-dyscrasias-special-issue
#14
EDITORIAL
David Keren, Christopher R McCudden, Ronald A Booth
No abstract text is available yet for this article.
October 27, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29111448/next-generation-sequencing-as-a-follow-up-test-in-an-expanded-newborn-screening-programme
#15
Smon Andraz, Repic Lampret Barbka, Groselj Urh, Zerjav Tansek Mojca, Kovac Jernej, Perko Dasa, Bertok Sara, Battelino Tadej, Trebusak Podkrajsek Katarina
OBJECTIVES: Contrary to many western European countries, most south-eastern European countries do not have an expanded newborn screening (NBS) program using tandem mass spectrometry. This study would represent one of the first expanded NBS studies in south-eastern Europe and will enable the estimation of the incidences of IEM in Slovenia. We proposed an expanded NBS approach including next-generation sequencing (NGS) as a confirmational analysis. DESIGN & METHODS: We conducted a pilot study of expanded NBS for selected inborn errors of metabolism (IEM) in Slovenia including 10,048 NBS cards...
October 27, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29107011/moving-standard-deviation-and-moving-sum-of-outliers-as-quality-tools-for-monitoring-analytical-precision
#16
Jiakai Liu, Chin Hon Tan, Tony Badrick, Tze Ping Loh
INTRODUCTION: An increase in analytical imprecision (expressed as CVa) can introduce additional variability (i.e. noise) to the patient results, which poses a challenge to the optimal management of patients. Relatively little work has been done to address the need for continuous monitoring of analytical imprecision. METHODS: Through numerical simulations, we describe the use of moving standard deviation (MovSD) and a recently described moving sum of outlier (movSO) patient results as means for detecting increased analytical imprecision, and compare their performances against internal quality control (QC) and the average of normal (AoN) approaches...
October 26, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29079359/the-copeptin-response-after-physical-activity-is-not-associated-with-cardiac-biomarkers-or-asymptomatic-coronary-artery-disease
#17
Kristin M Aakre, Øyunn Kleiven, Øyvind Skadberg, Magnus F Bjørkavoll-Bergseth, Tor Melberg, Heidi Strand, Tor-Arne Hagve, Stein Ørn
BACKGROUND: Copeptin concentrations increase both during acute coronary syndrome and following physical exercise. The relationship between copeptin increase following physical exercise and coronary artery disease (CAD) is uncertain. The aim of this study was to 1) describe the copeptin response following strenuous physical exercise, and 2) investigate the determinants of exercise induced copeptin concentrations, particularly in relation to cardiac biomarkers and CAD. METHODS: Serum samples were collected from 97 recreational cyclists 24h before, and immediately, 3 and 24h after a 91-km bike race...
October 25, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29079358/monoclonal-protein-reference-change-value-as-determined-by-gel-based-serum-protein-electrophoresis
#18
Mina Salamatmanesh, Christopher R McCudden, Arleigh McCurdy, Ronald A Booth
INTRODUCTION: The International Myeloma Working Group recommendations for monitoring disease progression or response include quantitation of the involved monoclonal immunoglobulin. They have defined the minimum change criteria of ≧25% with an absolute change of no <5g/L for either minimal response or progression. Limited evidence is available to accurately determine the magnitude of change in a monoclonal protein to reflect a true change in clinical status. Here we determined the analytical and biological variability of monoclonal proteins in stable monoclonal gammopathy of undetermined significance (MGUS) patients...
October 24, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29074091/fibroblast-growth-factor-23-in-patients-with-acute-dyspnea-data-from-the-akershus-cardiac-examination-ace-2-study
#19
Magnus Nakrem Lyngbakken, Mohammad Osman Pervez, Jon Brynildsen, Marit Holmefjord Pedersen, Janne Sølvernes, Geir Christensen, Arne Didrik Høiseth, Torbjørn Omland, Helge Røsjø
BACKGROUND: Circulating fibroblast growth factor 23 (FGF23) concentrations have been linked to left ventricular remodeling and unfavorable cardiovascular outcomes, but whether FGF23 is associated with heart failure (HF) diagnosis and outcome in unselected patients with dyspnea is unknown. Accordingly, we assessed the diagnostic and prognostic properties of FGF23 in patients presenting to the emergency department with acute dyspnea. METHODS AND RESULTS: FGF23 was measured in 314 patients admitted with acute dyspnea and the diagnostic and prognostic merit was compared to that of N-terminal pro-B-type natriuretic peptide (NT-proBNP)...
October 24, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29061378/candidate-recommendations-for-protein-electrophoresis-reporting-from-the-canadian-society-of-clinical-chemists-monoclonal-gammopathy-working-group
#20
Ronald A Booth, Christopher R McCudden, Cynthia M Balion, Ivan M Blasutig, Ihssan Bouhtiauy, Karina Rodriguez-Capote, Peter Catomeris, Pak Cheung Chan, Yu Chen, Christine Collier, Kristin Hauff, Jawahar Kalra, Dailin Li, Dan C Lin, Amy H Lou, Qing H Meng, Tracy Morrison, Maria D Pasic, Mabood Qureshi, Ed Randell, Kun-Young Sohn, Vinita Thakur, Dylan Thomas, Andrea Thoni, Cheryl Tomalty, Mohebullah Zamkanei
Protein electrophoresis is commonly used as an aid in the diagnosis of monoclonal gammopathies and is performed in many laboratories in Canada and throughout the world. However, unlike many other diagnostic tests, there is limited guidance for standardization and neither guidance nor specific recommendations for clinical reporting of serum (SPE) or urine (UPE) protein electrophoresis and immunotyping available in the literature. Therefore, a Canadian effort was undertaken to recommend standards that cover all aspects of clinical reporting with an ultimate goal towards reporting standardization...
October 20, 2017: Clinical Biochemistry
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