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Clinical Biochemistry

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https://www.readbyqxmd.com/read/28212987/corrigendum-to-an-increased-cdt-camouflaged-a-monoclonal-light-chain-gammopathy-an-approach-for-diagnosis-clin-biochem-49-2016-835-838
#1
M Barbaro, G Passerini, M Trbos, A Soldarini, M Locatelli
No abstract text is available yet for this article.
February 14, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28202345/circulating-human-leucine-rich-%C3%AE-2-glycoprotein-1-mrna-and-protein-levels-to-detect-acute-appendicitis-in-patients-with-acute-abdominal-pain
#2
T H Rainer, L Y Leung, Cpy Chan, Y K Leung, N M Cheng, Pbs Lai, Y S Cheung, C A Graham
BACKGROUND: Elevated levels of circulating plasma and urine leucine-rich-2-glycoprotein-1 (LRG1) protein has been found in patients with acute appendicitis (AA) and may be useful for diagnosis. This study aimed to investigate whether combined tests including circulating LRG1 mRNA levels improves the early diagnosis of AA. METHODS: Between December 2011 and October 2012, a prospective study was conducted on patients aged 18years or older presenting to the ED with acute abdominal pain (<7days of symptom onset)...
February 12, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28193484/clearance-of-cardiac-troponin-t-with-and-without-kidney-function
#3
Vincent Fridén, Karin Starnberg, Aida Muslimovic, Sven-Erik Ricksten, Christian Bjurman, Niklas Forsgard, Anna Wickman, Ola Hammarsten
OBJECTIVE: The extent of kidney-dependent clearance of the cardiac damage biomarker cardiac troponin T (cTnT) is not known. METHODS AND RESULTS: We examined clearance of cTnT after injection of heart extracts in rats with or without clamped kidney vessels. The extent of degradation of cTnT to fragments able to pass the glomerular membrane and the kidney extraction index of cTnT was examined in human subjects. After a bolus injection of rat cardiac extract, simulating a large myocardial infarction, there was no significant difference in clearance of cTnT with or without kidney function...
February 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28192126/the-small-number-problem-in-diagnostic-algorithms-and-why-we-need-to-bootstrap
#4
LETTER
John W Pickering, Martin P Than
No abstract text is available yet for this article.
February 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28192125/clinical-implications-for-biochemical-diagnostic-thresholds-of-adrenal-sufficiency-using-a-highly-specific-cortisol-immunoassay
#5
G A Kline, J Buse, R D Krause
OBJECTIVES: Recent guidelines recommend a diagnosis of adrenal insufficiency when a stimulated peak cortisol level falls below 500nmol/L. This may not be valid using a highly specific cortisol immunoassay or liquid chromatography-mass spectroscopy (LCMS/MS). We sought to determine the diagnostic threshold for adrenal insufficiency using a new and widely available, highly specific cortisol immunoassay. DESIGN: All patients having a dynamic test of adrenal reserve had results measured using the historical cortisol assay (Roche Cortisol) and the newer assay (Roche Cortisol II)...
February 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28188739/comparison-of-automated-devices-ux-2000-and-sedimax-autionmax-for-urine-samples-screening-a-multicenter-spanish-study
#6
Catalina Sánchez-Mora, Delia Acevedo, Maria Amelia Porres, Ana María Chaqués, Javier Zapardiel, Aurelia Gallego-Cabrera, Jose María López, Jose María Maesa
OBJECTIVES: In this study we aim to compare UX2000 (Sysmex Corp, Japan) and SediMAX/AutionMax (Arkray Factory Inc., Japan), totally automatized analyzers, against Fuchs-Rosenthal counting chamber, the gold standard technique for sediment analysis. DESIGN AND METHODS: Urine samples of 1454 patients from three Spanish hospitals were assessed for red and white blood cells (RBC; WBC) using three different techniques: flow cytometry, image-based method and Fuchs-Rosenthal counting chamber...
February 7, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28188738/complement-component-3-c3-as-a-biomarker-for-insulin-resistance-after-bariatric-surgery
#7
Letícia de Oliveira Souza Bratti, Ícaro Andrade Rodrigues do Carmo, Taís Ferreira Vilela, Sandro Wopereis, Ana Carolina Rabello de Moraes, Beatriz Garcia Mendes Borba, Liliete Canes Souza, Fabíola Branco Filippin-Monteiro
OBJECTIVES: Since complement system has been recently associated with metabolic and cardiovascular diseases, and closely related to insulin resistance, we investigated the association of plasma complement factor 3 (C3) and factor 4 (C4) with insulin sensibility and weight loss after bariatric surgery. METHODS: Serum levels of C3, C4, total cholesterol, triacylglycerol, HDL-cholesterol, LDL-cholesterol and homeostatic model assessment (HOMA-IR) measurements were assessed in morbidly obese patients before and after bariatric surgery, including a 6-month follow-up period, as well as a comparison with a lean group...
February 7, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28179154/managing-the-patient-identification-crisis-in-healthcare-and-laboratory-medicine
#8
REVIEW
Giuseppe Lippi, Camilla Mattiuzzi, Chiara Bovo, Emmanuel J Favaloro
Identification errors have emerged as a critical issue in health care, as testified by the ample scientific literature on this argument. Despite available evidence suggesting that the frequency of misidentification in vitro laboratory diagnostic testing may be relatively low compared to that of other laboratory errors (i.e., usually comprised between 0.01 and 0.1% of all specimens received), the potential adverse consequences remain particularly worrying, wherein 10-20% of these errors not only would translate into serious harm for the patient, but may also erode considerable human and economic resources, so that the entire healthcare system should be re-engineered to act proactively and limiting the burden of this important problem...
February 5, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28167246/performance-specifications-for-the-extra-analytical-phases-of-laboratory-testing-why-and-how
#9
REVIEW
Mario Plebani
An important priority in the current healthcare scenario should be to address errors in laboratory testing, which account for a significant proportion of diagnostic errors. Efforts made in laboratory medicine to enhance the diagnostic process have been directed toward improving technology, greater volumes and more accurate laboratory tests being achieved, but data collected in the last few years highlight the need to re-evaluate the total testing process (TTP) as the unique framework for improving quality and patient safety...
February 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28167245/effects-of-paraoxonase-arylesterase-ceruloplasmin-catalase-and-myeloperoxidase-activities-on-prognosis-in-pediatric-patients-with-sepsis
#10
Ganime Ayar, Yasemin Men Atmaca, Murat Alışık, Özcan Erel
BACKGROUND: The present study aimed to investigate the levels of paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARE), ceruloplasmin (CLP), myeloperoxidase (MPO), and catalase (CAT) in pediatric sepsis and to explore their effects on the prognosis of sepsis. METHODS: Patients diagnosed with sepsis (n=33) and healthy controls (n=30) were included. PON, SPON, ARE, CLP, MPO, and CAT activities were measured in the sepsis and control groups. Additionally, the parameters were compared between survivors and non-survivors in the sepsis group...
February 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28167244/impact-of-risperidone-on-leptin-and-insulin-in-children-and-adolescents-with-autistic-spectrum-disorders
#11
Pornpen Srisawasdi, Natchaya Vanwong, Yaowaluck Hongkaew, Apichaya Puangpetch, Somlak Vanavanan, Boontarika Intachak, Nattawat Ngamsamut, Penkhae Limsila, Chonlaphat Sukasem, Martin H Kroll
OBJECTIVE: To evaluate the influence of dose and duration of risperidone treatment on cardiovascular and diabetes risk biomarkers in children and adolescents with autistic spectrum disorders (ASDs). DESIGN AND METHODS: In this cross-sectional analysis, a total of 168 ASDs patients (89% male) treated with a risperidone-based regimen for ≥12months were included. Blood samples were analyzed for glucose and lipid metabolic markers, adiponectin, leptin, prolactin, cortisol and high sensitive C-reactive protein...
February 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28163015/a-pragmatic-approach-to-sample-acceptance-and-rejection
#12
Janne Cadamuro, Ana-Maria Simundic, Eva Ajzner, Sverre Sandberg
Sample rejection due to preanalytical errors is very common in many medical laboratories worldwide, though the decision when and how to refrain from analyzing such samples is handled very heterogeneously. As a rational, it is mostly stated that it is done to prevent the patient from being harmed by wrong medical decisions based on such values. But when thinking of the consequences of laboratory results instead of their quality being important per se, the rejection of preanalytically altered samples might be harming the patient by the need of re-collection and timely delay...
February 2, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28161191/laboratory-diagnosis-of-gestational-diabetes-an-in-silico-investigation-into-the-effects-of-pre-analytical-processing-on-the-diagnostic-sensitivity-and-specificity-of-the-oral-glucose-tolerance-test
#13
Erin Mansell, Helen Lunt, Paul Docherty
INTRODUCTION: Delayed separation of red cells from plasma causes pre analytical glucose loss, which in turn results in an under-diagnosis of GDM (gestational diabetes) based on the OGTT (oral glucose tolerance test). In silico investigations may help laboratory decision making, when exploring pragmatic improvements to sample processing. METHODS: Late pregnancy 0, 1 and 2h 75g OGTT values were obtained from two distinct populations of pregnant women: 1. Values derived from the HAPO (Hyperglycemia and Adverse Pregnancy Outcome) Study and 2...
February 2, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28132756/identification-of-three-novel-mutations-in-fourteen-patients-with-citrullinemia-type-1
#14
Engin Kose, Ozlem Unal, Selda Bulbul, Mehmet Gunduz, Johannes Häberle, Nur Arslan
OBJECTIVES: Citrullinemia type 1 (CTLN1) is an autosomal recessive genetic disorder caused by mutations in the argininosuccinate synthetase 1 (ASS1) gene, which encodes for the argininosuccinate synthetase enzyme. Here, we report genetic and clinical characterizations of 14 patients with citrullinemia type 1. DESIGN & METHODS: The study group consisted of 14 patients (4 females, 10 males) diagnosed with citrullinemia type 1 from three centers in Turkey. Age of onset, clinical presentation, initial citrulline and ammonia levels, family history and molecular genetic analysis were retrospectively evaluated...
January 26, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28122197/quantification-of-multiple-elements-in-dried-blood-spot-samples
#15
Lise Pedersen, Karen Andersen-Ranberg, Mads Hollergaard, Mads Nybo
BACKGROUND: Dried blood spots (DBS) is a unique matrix that offers advantages compared to conventional blood collection making it increasingly popular in large population studies. We here describe development and validation of a method to determine multiple elements in DBS. METHODS: Elements were extracted from punches and analyzed using inductively coupled plasma-mass spectrometry (ICP-MS). The method was evaluated with quality controls with defined element concentration and blood spiked with elements to assess accuracy and imprecision...
January 22, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28109748/chronic-proton-pump-inhibition-therapy-in-the-diagnostic-accuracy-of-serum-pepsinogen-i-and-gastrin-concentrations-to-identify-pernicious-anaemia
#16
Mariam Martín-Alcolea, Inés Rodríguez-Hernández, Marta Aldea, Irene Rosas, Jordi Juncà, Maria Luisa Granada
BACKGROUND: Chronic use of proton pump inhibitors (PPIs) leads to increases in gastrin and pepsinogen-I serum concentrations. AIM: To asses if chronic treatment with PPIs has an effect on serum gastrin and pepsinogen-I concentrations for the diagnosis of pernicious anaemia (PA). MATERIALS AND METHODS: Serum gastrin and pepsinogen-I were measured in 38 patients with PA and 74 without PA (controls); 17/38 PA patients and 36/74 controls were treated with PPIs...
January 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28108166/predictive-performance-of-different-kidney-function-estimation-equations-in-lung-transplant-patients
#17
Dov A Degen, Jyotsna Janardan, Katherine A Barraclough, Hans G Schneider, Thomas Barber, Howard Barton, Gregory Snell, Bronwyn Levvey, Rowan G Walker
BACKGROUND: There has been limited examination of the performance of glomerular filtration rate estimation (eGFR) equations in lung transplant populations. This study aimed to compare the performance of serum creatinine and cystatin C based eGFR equations with Tc-99m diethylenetriaminepentaacetic acid (DTPA) GFR measurements in individuals with end-stage lung disease, either prior to, or following, lung transplantation. METHODS: In this prospective observational study, participants underwent GFR measurements with Tc-99m Pentetate...
January 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28093196/a-prospective-single-centre-pilot-evaluation-of-a-serum-calprotectin-assay-in-unselected-gi-patients
#18
Rebecca K McCann, Karen Smith, Daniel R Gaya
BACKGROUND: Whilst C-reactive protein (CRP) is an established serum marker of inflammation, its use in gastroenterology has been limited by its poor sensitivity and specificity for GI disease. Faecal calprotectin (FC) has been adopted into mainstream GI practice as a sensitive but non-specific marker of intestinal inflammation. However, stool samples collection for FC can be challenging and the possibility of utilising a sensitive and specific serum biomarker of intestinal inflammation in luminal gastroenterology is an attractive prospect...
January 16, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28095311/therapeutic-drug-monitoring-key-to-personalized-pharmacotherapy
#19
Michael Oellerich, Philipp Kanzow, Philip D Walson
No abstract text is available yet for this article.
January 14, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28088454/alpha-l-iduronidase-and-arylsulfatase-b-in-dried-blood-spots-on-filter-paper-biochemical-parameters-and-time-stability
#20
Ana Carolina Breier, Jaqueline Cé, Jamila Mezzalira, Vanessa V Daitx, Vitoria C Moraes, Mariana P S Goldim, Janice C Coelho
BACKGROUND: The goal of this study was to assess the biochemical parameters of the enzymes α-l-iduronidase (IDUA) and arylsulfatase B (ASB), which are deficient in mucopolysaccharidosis (MPS) I and VI, respectively, in dried blood spot (DBS) samples impregnated on filter paper. METHODS AND RESULTS: The optimal pH, Km, and Vmax of IDUA and ASB in DBS are hereby presented. After these analyses, the reference values for the activities of these enzymes in DBS with cutoff of 3...
January 11, 2017: Clinical Biochemistry
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