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Clinical Biochemistry

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https://www.readbyqxmd.com/read/28512013/evaluation-of-the-n-latex-serum-free-light-chain-assay-on-the-siemens-bnii-analyzer-and-agreement-with-the-binding-site-freelite-assay-on-the-spaplus
#1
Nicole M A White-Al Habeeb, Tammy Earle, Megan Spencer, Ivan M Blasutig
OBJECTIVES: To evaluate the Siemens N-latex kappa free light chain (κFLC) and lambda FLC (λFLC) assays on the BNII nephelometer and assess agreement with The Binding Site Freelite FLC assays on the SPAPlus. DESIGN AND METHODS: Over 180 patient serum samples from routine analysis of κFLC and λFLC measured by the Freelite assay were collected for the study and measured with the N-latex κFLC and λFLC assays to assess precision, linearity, method comparison and dilutional effects...
May 13, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28499800/improving-clinical-laboratory-performance-through-quality-indicators
#2
EDITORIAL
Magdalena Krintus, Mario Plebani, Mauro Panteghini
No abstract text is available yet for this article.
May 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28499801/the-effect-of-admission-serum-potassium-levels-on-in-hospital-and-long-term-mortality-in-type-a-acute-aortic-dissection
#3
Zhaoran Chen, Bi Huang, Haisong Lu, Zhenhua Zhao, Rutai Hui, Shu Zhang, Yanmin Yang, Xiaohan Fan
BACKGROUND: Mild fluctuations in serum potassium (K(+)) levels are related to the prognosis of cardiovascular disease. This study aimed to determine the effect of admission serum potassium levels on in-hospital and long-term mortality in patients with Stanford type A acute aortic dissection (AAD). MATERIALS AND METHODS: A total of 588 consecutive patients with type A AAD were enrolled, and they were grouped according to admission serum potassium level: <3.5, 3...
May 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28495185/association-of-circulatory-asymmetric-dimethylarginine-adma-with-diabetic-nephropathy-in-asian-indians-and-its-causative-role-in-renal-cell-injury
#4
Isaivani Jayachandran, Saravanakumar Sundararajan, Prabu Paramasivam, Balachandar Venkatesan, Shanthirani C Subramanian, Muthuswamy Balasubramanyam, Viswanathan Mohan, Nagaraj Manickam
AIM: Asymmetric dimethylarginine (ADMA) is involved in the regulation of nitric oxide synthesis and in the maintenance of vascular tone and structure. But the role and status of ADMA in diabetes induced kidney injury is not clear. Hence this study is investigating the role of ADMA in the progression of kidney injury and its circulatory status in Asian Indians with and without diabetic nephropathy. METHODS: Recruited study subjects were divided into normal glucose tolerance (NGT), type 2 diabetes mellitus (T2DM) and T2DM with micro or macroalbuminuria...
May 8, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28483407/evaluation-of-diagnostic-accuracy-of-two-rapid-stool-antigen-tests-using-an-immunochromatographic-assay-to-detect-helicobacter-pylori
#5
Joyce Matie Kinoshita da Silva-Etto, Rejane Mattar, Cibele Aparecida Villares-Lopes, Sergio Barbosa Marques, Flair José Carrilho
OBJECTIVES: The stool antigen assay for H. pylori infection diagnosis with monoclonal antibodies is a simple and recommended technique by the Maastricht V/Florence consensus report. Recently, Pylori K-Set K-1219 (Coris Bioconcept Sprl, Belgium) and HP-F23 (Symbiosys, Brazil) have been made commercially available in Brazil. Thus, the aim of this study was to evaluate the diagnostic accuracies of these two rapid stool antigen tests by immunochromatographic assays (index tests) for the clinical practice...
May 5, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28483406/rates-of-inappropriate-laboratory-test-utilization-in-ontario
#6
Nadine Chami, Janet Simons, Arthur Sweetman, Andrew C Don Wauchope
BACKGROUND: Medical laboratory tests ordered redundantly represent one of the targets for reducing diagnostic testing without negatively, and possibly positively, affecting patient care. We study a clearly defined category of excessive laboratory utilization for nine analytes where inappropriate diagnostic testing is defined in terms of the time interval between tests; that is, ordering a test too soon following the previous order of the same test. METHODS: Population data from the near universal public Ontario Health Insurance Plan for the years 2006-2010 are employed where the tests are fulfilled by community medical laboratories...
May 5, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28479151/laboratory-testing-for-monoclonal-gammopathies-focus-on-monoclonal-gammopathy-of-undetermined-significance-and-smoldering-multiple-myeloma
#7
REVIEW
Maria A V Willrich, David L Murray, Robert A Kyle
Monoclonal gammopathies (MG) are defined by increased proliferation of clonal plasma cells, resulting in a detectable abnormality called monoclonal component or M-protein. Detection of the M-protein as either narrow peaks on protein electrophoresis and discrete bands on immunofixation is the defining feature of MG. MG are classified as low-tumor burden disorders, pre-malignancies and malignancies. Since significant disease can be present at any level, several different tests are employed in order to encompass the inherent diverse nature of the M-proteins...
May 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28479150/glucose-6-phosphate-dehydrogenase-enzyme-stability-in-filter-paper-dried-blood-spots
#8
Sharon R Flores, Elizabeth M Hall, Víctor R De Jesús
OBJECTIVE: Prior to initial distribution of Glucose-6-phosphate dehydrogenase (G6PD) proficiency testing (PT) materials, we evaluated G6PD enzyme stability in dried blood spots (DBS) under various temperature and humidity environments to develop storage and usage guidelines for our new materials. DESIGN & METHODS: We prepared fresh G6PD-normal DBS materials and conducted stability evaluations of daily use and short and long-term storage under various temperature and humidity environments...
May 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28478046/two-cases-of-spontaneous-remission-of-non-parasitic-chyluria
#9
Damodara Rao Mendu, Hillel Sternlicht, Lakshmi V Ramanathan, Melissa S Pessin, Martin Fleisher, Guido Dalbagni, Edgar A Jaimes, Anna Kaltsas, Ilya G Glezerman
OBJECTIVES: Chyluria is a medical condition with presence of chyle in urine. The disease is most prevalent in South East Asian countries mostly caused by parasitic (Wuchereria bancrofti) infections. Our objective was to investigate the spontaneous remission of non-parasitic chyluria. DESIGN AND METHODS: The spontaneous remission of non-parasitic chyluria cases were worked out with diagnostic investigations, clinical assessment and studied with details of all aspects with evolutionary totality...
May 3, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28457964/multiple-pre-and-post-analytical-lean-approaches-to-the-improvement-of-the-laboratory-turnaround-time-in-a-large-core-laboratory
#10
Amy H Lou, Manal O Elnenaei, Irene Sadek, Shauna Thompson, Bryan D Crocker, Bassam A Nassar
BACKGROUND: Core laboratory (CL), as a new business model, facilitates consolidation and integration of laboratory services to enhance efficiency and reduce costs. This study evaluates the impact of total laboratory automation system (TLA), electric track vehicle (ETV) system and auto-verification (AV) of results on overall turnaround time (TAT) (phlebotomy to reporting TAT: PR-TAT) within a CL setting. METHODS: Mean, median and percentage of outlier (OP) for PR-TAT were compared for pre- and post-CL eras using five representative tests based on different request priorities...
April 27, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28456545/galectin-3-in-acute-coronary-syndrome
#11
REVIEW
Luisa Agnello, Giulia Bivona, Bruna Lo Sasso, Concetta Scazzone, Viviana Bazan, Chiara Bellia, Marcello Ciaccio
Acute coronary syndrome (ACS) is a very common cause of hospitalizations worldwide each year. In the past decades biomarkers have become an indispensable tool for diagnosis, risk stratification and prognosis of cardiovascular disease, including ACS. Despite Troponin is considered the gold standard in diagnosis of ACS, several molecules have been investigated to identify predictive biomarkers of prognosis. Among these, Gal-3 has emerged as a promising prognostic marker. It has a pivotal role in inflammation and fibrosis...
April 26, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28442257/cocaine-use-is-associated-with-a-higher-prevalence-of-elevated-st2-concentrations
#12
Xander M R van Wijk, Eric Vittinghoff, Alan H B Wu, Kara L Lynch, Elise D Riley
BACKGROUND: Cocaine is a well-known risk factor for acute cardiac events, but the effects in users outside of acute events are less clear. We investigated a possible association between cocaine use and the concentration of a novel biomarker for cardiac stress and heart failure, ST2. METHODS: A case-control study was conducted to compare ST2 concentrations by the presence of cocaine in patients presenting for care, but not cardiac care, at an urban safety net hospital...
April 23, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28438460/alternative-process-for-quantifying-na-and-k-electrolytes-in-plasma-with-high-paraprotein-concentration-using-an-automated-analyzer
#13
LETTER
V Platzer, B Hebraud, E Caussé
No abstract text is available yet for this article.
April 22, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28434985/performance-specifications-in-extra-analytical-phase-of-laboratory-testing-sample-handling-and-transportation
#14
Martina Zaninotto, Adriano Tasinato, Gianni Vecchiato, Angelo Legnaro, Alessio Pinato, Mario Plebani
No abstract text is available yet for this article.
April 21, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28434987/appraising-laboratory-quality-and-value-what-s-missing
#15
Paul L Epner
No abstract text is available yet for this article.
April 20, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28434986/the-emerging-landscape-of-scientific-publishing
#16
REVIEW
Clare Fiala, Eleftherios P Diamandis
We present emerging models of publishing which have grown from the phenomenon of open access, the changing role of peer review in the scientific process and the new position of the impact factor. We juxtapose the new models of paid review, eponymous review, no review, post publication review and light review with the classic model which has dominated for a century, detailing advantages, problems and examples of each model to provide a comprehensive overview of the changing landscape of scientific publishing...
April 20, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28433611/preanalytical-variables-for-liquid-chromatography-mass-spectrometry-lc-ms-analysis-of-human-blood-specimens
#17
REVIEW
Gian Luca Salvagno, Elisa Danese, Giuseppe Lippi
The use of liquid chromatography-mass spectrometry (LC-MS) for both diagnostics and research purposes is rapidly growing in clinical laboratories. As for more conventional areas of in vitro diagnostic testing, many preanalytical variables have an impact on these techniques and may hence jeopardize the quality of tests results. The leading preanalytical variables include patient preparation, the nature of the blood collection tubes and additives, interference from spurious hemolysis, sample handling and management, composition of blood tubes, contamination, as well as storage conditions...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28433610/paraoxonases-and-infectious-diseases
#18
REVIEW
Jordi Camps, Simona Iftimie, Anabel García-Heredia, Antoni Castro, Jorge Joven
The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28433609/hb-moncloa-a-new-variant-of-haemoglobin-that-interferes-in-the-quantification-of-hb-a1c
#19
Torrejón María Josefa, Ortíz-Cabrera N Valentina, M Nieto Jorge, González Fernández Fernando-Ataúlfo, Villegas Ana, Martínez Rafael, Ropero Paloma
BACKGROUND: In most routine laboratories in Spain, the commonly used method for evaluating HbA1c is ion-exchange high performance liquid chromatography (HPLC). The presence of a variant of Hb may interfere with the quantification of HbA1c. AIMS: Here, we report a novel haemoglobin variant, named Hb Moncloa, which was found during a routine health check at the Hospital Clínico San Carlos in Moncloa (Madrid), Spain. METHODS AND RESULTS: Molecular characterization of β gene identified a novel transversion mutation [β80(EF4)Asn>Ser; HBB:c...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28427918/endocan-is-a-stable-circulating-molecule-in-icu-patients
#20
Gaudet Alexandre, Chenevier-Gobeaux Camille, Parmentier Erika, Delobel Jean-Edouard, Dubucquoi Sylvain, Mathieu Daniel, Lassalle Philippe, De Freitas Caires Nathalie
BACKGROUND: Endocan is a lung endothelial cell secreted proteoglycan, possessing multiple physiological roles and potential therapeutic and diagnostic utility as biomarker in pneumonia and acute respiratory distress syndrome. Endocan synthesis and secretion can be induced by proinflammatory cytokines such as TNF-α, but can also be subject of proteolytic degradation causing preanalytical variation. METHODS: We investigated the stability of endocan in conventional serum, plasma, anticoagulated whole blood, as well as whole blood and plasma stabilized with protease inhibitors...
April 17, 2017: Clinical Biochemistry
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