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Clinical Biochemistry

Claudio Lera Orsatti, Marcone Lima Sobreira, Valéria Cristina Sandrim, Jorge Nahas-Neto, Fabio Lera Orsatti, Eliana Aguiar Petri Nahas
BACKGROUND: Early identification of asymptomatic postmenopausal women (PW), who are more predisposed to developing cardiovascular disease (CVD), is an important preventive strategy. Autophagy-related 16-like 1 (ATG16L1) is an autophagy gene known to control host immune responses and is associated with a variety of diseases, including CVD. OBJECTIVE: The aim of the study was to associate the ATG16L1 polymorphism variant with subclinical carotid atherosclerosis in asymptomatic PW...
September 17, 2018: Clinical Biochemistry
Philip M Sobolesky, Breland E Smith, Amy K Saenger, Karen Schulz, Fred S Apple, Mitchell G Scott, Alan H B Wu, Randie R Little, Robert L Fitzgerald
OBJECTIVE: A multisite investigation compared the analytical performance of a point-of-care (POC) HbA1c device with multiple commonly used HbA1c laboratory methods and an NGSP (National Glycohemoglobin Standardization Program) reference method. RESEARCH DESIGN AND METHODS: The Afinion AS100 POC device analyzed HbA1c using 618 EDTA whole blood excess patient specimens with clinically indicated HbA1c testing. Results were compared to measurements across five clinical laboratories and the NGSP reference method...
September 17, 2018: Clinical Biochemistry
Damien Gruson, Vincenzo Carbone, Benjamin Feracin, Sylvie A Ahn, Michel F Rousseau
Fibroblast growth factor 23 (FGF-23), a key hormone for the regulation of the phosphorus homeostasis, has also several direct effects on cardiac function. In heart failure (HF), the increase of FGF-23 participates to cardiac hypertrophy and remodeling. Measurement of the intact, biologically active hormone is now available. We determined intact FGF-23 in HF patients with reduced ejection fraction and assess its prognosis value for cardiovascular death over a long-term follow-up. We observed that intact FGF-23 is an independent predictor of cardiovascular death in HF patients and provides added value to the standard of care, natriuretic peptide, for risk estimation...
September 8, 2018: Clinical Biochemistry
Srilatha Kadali, Tumuluri Madalasa, Gummadi Maheshwar Reddy, Shaik Mohammad Naushad
OBJECTIVE: Plasma chitotriosidase is a documented biomarker for certain lysosomal storage disorders. However, its clinical utility for prenatal samples is not elucidated yet. METHODS: We have established Reference intervals for amniotic fluid chitotriosidase using control amniotic fluids (n = 47) and compared the activity with amniotic fluids affected by lysosomal storage disorders (n = 25). RESULTS: The reference interval established was 0-6...
September 8, 2018: Clinical Biochemistry
Wenjuan Wang, Junxia Lv, Nan Chen, Bin Lou, Weilin Mao, Peipei Wang, Yu Chen
BACKGROUND: Correct staging of hepatocellular carcinoma (HCC) could help physicians to precisely select treatments for patients, such as surgery, chemotherapy, or their combination. The objective of this study was to explore potential metabolic markers for staging of hepatocellular carcinoma. METHODS: By liquid chromatography with mass spectrometry (LC-MS), the serum metabolic profiles of 60 pathologically confirmed hepatocellular carcinoma (HCC) patients were analyzed using the TNM staging system and Chinese staging system...
September 6, 2018: Clinical Biochemistry
Oranite Goldrat, Anne Delbaere
No abstract text is available yet for this article.
September 6, 2018: Clinical Biochemistry
Vivek Kumar Garg, Rimpy Charak, Neelam Goel
No abstract text is available yet for this article.
September 1, 2018: Clinical Biochemistry
Saranya Kittanakom, Veronica Donohue, Jacqueline Beattie, Lorna Clark, Peter A Kavsak
No abstract text is available yet for this article.
September 1, 2018: Clinical Biochemistry
Lucie Petrova, Filip Vrbacky, Miriam Lanska, Alzbeta Zavrelova, Pavel Zak, Katerina Hrochova
OBJECTIVES: Molecular screening plays a major role in prognostic categorization and subsequent definition of treatment strategies for acute myeloid leukemia. The possibility of using IDH1/2 mutations as a marker for the monitoring of minimal residual disease (MRD) is still under investigation and remains unclear. METHODS: In this retrospective study, we evaluated 90 patients with de novo AML using Sanger sequencing (exon 4, IDH1 and IDH2). For subsequent MRD monitoring were used both methods, massive parallel sequencing and droplet digital PCR (ddPCR)...
August 31, 2018: Clinical Biochemistry
Pedro Garrido, Conxita Rovira, Pitter Cueto, Isabel Fort-Gallifa, Anna Hernández-Aguilera, Noemí Cabré, Fedra Luciano-Mateo, Anabel García-Heredia, Jordi Camps, Jorge Joven, Elisabeth Garcia, Immaculada Vallverdú
BACKGROUND: Acute renal failure in patients with sepsis is associated with high mortality. Studies have highlighted alterations in serum paraoxonase-1 in severe infections. However, the published literature has no insight into the clinical evolution of these parameters in patients with sepsis and acute renal failure treated with extra-renal depuration techniques. METHODS: We studied 25 patients with sepsis and acute renal failure who were treated with continuous renal-replacement therapy...
August 27, 2018: Clinical Biochemistry
Betül Özbek İpteç, Ahmet Rıfat Balik, Selcen Yüksel, Fatma Meriç Yilmaz, Gülsen Yilmaz
INTRODUCTION: Low-density lipoprotein cholesterol (LDL) is an important risk factor for cardiovascular disease (CVD) and generally measured after 8-12 h fasting. However, some recent studies have pointed that non-fasting lipoproteins, especially LDL concentrations, are better indicators for demonstrating CVD risk and atherosclerosis. They asserted that nutrition is a negligible factor on changes in lipoprotein concentrations and claimed this difference as a result of hemodilution effect, caused from fluid intake and can be eliminated by applying some adjustments...
August 25, 2018: Clinical Biochemistry
Maria Lopez-Molina, Cecilia Santillan, Marta Murillo, Aina Valls, Laura Bosch, Joan Bel, María Luisa Granada
BACKGROUND: vitamin D deficiency in children is still a global health problem. Measuring free 25-hydroxyvitamin D concentrations could provide a better estimate of the vitamin D status than total 25-hydroxyvitamin D (25(OH)D) levels. OBJECTIVE: To assess the relationship between measured free vitamin D (m-f25(OH)D) and calculated free 25(OH)D (c-f25(OH)D), total 25(OH)D, intact parathyroid hormone (iPTH) and other markers of phosphocalcic metabolism. To establish serum m-f25(OH)D concentrations corresponding to a total 25(OH)D > 50 nmol/L which is accepted as vitamin D-sufficiency status in children...
August 18, 2018: Clinical Biochemistry
Tzortzis Nomikos, Elizabeth Fragopoulou, Smaragdi Antonopoulou, Demosthenes B Panagiotakos
Platelet-activating factor (PAF) is a glycerylether lipid and one of the most potent endogenous mediators of inflammation. Through its binding to a well-characterized receptor it initiates a plethora of cellular pro-inflammatory actions participating by this way to the pathology of most chronic diseases, including cardiovascular and renal diseases, CNS decline and cancer. Among the variety of prudent dietary patterns, Mediterranean Diet (MD) is the dietary pattern with the strongest evidence for its ability to prevent the same chronic diseases...
September 2018: Clinical Biochemistry
Jingbin Guo, Qiushi Wang, Yangyang Liu, Lu Lu, Yue Hua, Rong Hu, Mingqing Wang, Zhiliang Li, Xianbao Wang, Bing Hui Wang, Qiang Fu, Aihua Chen
AIM: Messenger RNAs (mRNAs) play an important role in the pathogenesis of coronary artery disease (CAD). We evaluated the association of selected increase in mRNAs from monocytes with the risk of CAD. METHODS: Chip data (GSE9820) retrieved from Gene Expression Omnibus (GEO) was re-analyzed, and the selected candidate genes, meeting specific conditions, were up-regulated and verified for specific biomarkers of CAD within a prospective cohort study that recruited 194 individuals and subdivided into two groups: group Non-CAD (GN), n = 68 and group CAD (GC), n = 126...
September 2018: Clinical Biochemistry
Danchen Wang, Xinqi Cheng, Songlin Yu, Ling Qiu, Xiaolan Lian, Xiuzhi Guo, Yingying Hu, Shuangyu Lu, Guohua Yang, Huaicheng Liu
BACKGROUND: Thyroid-stimulating hormone (TSH) plays a key role in maintaining normal thyroid function. Here, we used "big data" to analyze the effects of seasonality and temperature on TSH concentrations to understand factors affecting the reference interval. METHODS: Information from 339,985 patients at Peking Union Medical College Hospital was collected from September 1st, 2013, to August 31st, 2016, and retrospectively analyzed. A statistical method was used to exclude outliers, with data from 206,486 patients included in the final analysis...
September 2018: Clinical Biochemistry
Milica Miljkovic, Aleksandra Stefanovic, Jelena Vekic, Aleksandra Zeljkovic, Tamara Gojkovic, Sanja Simic-Ogrizovic, Natasa Bogavac-Stanojevic, Darko Cerne, Jasmina Ilic, Ivan Stefanovic, Zorana Jelic-Ivanovic, Vesna Spasojevic-Kalimanovska, Jelena Kotur-Stevuljevic
INTRODUCTION: Cardiovascular complications, as the main cause of mortality in renal patients, are followed with altered lipoproteins composition. Considering that paraoxonase-1 (PON1) is an anti-oxidative enzyme located mainly on HDL particles, the current study has aim to investigate whether failure of kidney function leads to changes in the distribution of PON1 activity between different HDL subclasses. MATERIALS AND METHODS: In 77 renal patients (21 chronic kidney disease (CKD) and 56 end stage renal disease (ESRD) patients on dialysis) and 20 healthy subjects PON1 activity on HDL2 and HDL3 subclasses was determined by zymogram method that combines gradient gel electrophoresis separation of HDL subclasses and measurement of PON1 activity in the same gel...
September 2018: Clinical Biochemistry
Alejandra M Wiedeman, Roger A Dyer, Timothy J Green, Zhaoming Xu, Susan I Barr, Sheila M Innis, David D Kitts
BACKGROUND: Plasma concentrations of choline and its metabolites might serve as biomarkers for the health outcomes of several pathological states such as cardiovascular disease and cancer. However, information about the reliability of biomarkers of choline status is limited. We investigated biological variations in repeated measures of choline and metabolites in healthy adults to assess them as biomarkers. METHODS: Blood samples were collected after an overnight fast at three-time points 12 days apart from 40 adults (mean age, 33 y; male, n = 21)...
September 2018: Clinical Biochemistry
Simona Ferraro, Cristina Robbiano, Nicoletta Tosca, Andrea Panzeri, Anna Maria Paganoni, Mauro Panteghini
BACKGROUND: The addition of human epididymis protein 4 (HE4) to carbohydrate antigen 125 (CA125) in ovarian cancer (OC) assessment has been proposed. We compared the clinical value of biomarker changes in a prospective series of patients undergoing OC monitoring. METHODS: We studied 43 patients (79% post-menopausal), followed for 3.5 ± 3.1 years. Serous OC was prevalent (53.5%), with 81.4% of patients diagnosed at late stages. Both cut-offs and reference change values (RCV) were used for assessing significant marker changes...
September 2018: Clinical Biochemistry
Mehmet Arif Icer, Makbule Gezmen-Karadag, Sinan Sozen
BACKGROUND AND AIM: The nephrolithiasis has a multifactorial etiology resulting from the interaction of metabolic, genetic and environmental factors. Parameters such as nutrition and urinary osteopontin (OPN) level may affect kidney stone formation. The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis. MATERIALS AND METHODS: This study was conducted on 88 volunteers including 44 healthy individuals and 44 patients diagnosed with nephrolithiasis and aging between 20 and 65 years...
September 2018: Clinical Biochemistry
Isaac Barroso, Rui Farinha, João Tiago Guimarães
Zinc (Zn) is a ubiquitous element that plays a vital role in the growth and development of human body. Traditionally, Zn has been measured in plasma samples using "trace element" dedicated sampling tubes. However, the recent increase in its assessment leads to the need to use others than plasma samples and the use of sera could be a justified and valid alternative. We evaluated the differences between plasma and serum, for Zn quantification. 307 blood paired samples from patients enrolled for the treatment of obesity-related pathology at our out-patient department were assessed...
September 2018: Clinical Biochemistry
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