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Biochemical Genetics

Saeid Tamadoni Jahromi, Ahmad Sofiman Othman, Rusly Rosazlina
There are two morphotypes of Penaeus semisulcatus described hitherto in the Persian Gulf, namely the banded and non-banded antennae morphotypes. In this study, we used morphometric measurements and two mitochondrial genes (16S rRNA and cytochrome oxidase subunit I-COI) to assess relationships between the two morphotypes of P. semisulcatus. Out of 25 morphological characters examined, 10 characters were found significantly different between the two morphotypes when tested against separate sexes or both sexes combined...
August 12, 2018: Biochemical Genetics
Chenggui Miao, Zhongwen Xie, Jun Chang
The original version of this article unfortunately contained an error in the Acknowledgement section. The corrected text has been given below.
August 3, 2018: Biochemical Genetics
Ahmed F AbdEl-Hafez, Sherif H El-Alfy, Hamdy H Swelim, Nagwa H A Hassan
Egypt is a transcontinental country containing substantial ethnic, cultural, and linguistic diversity among its people. This study was conducted to investigate the genetic variation at 15 AmpFlSTR Identifiler short tandem repeat (STR) loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA, within and between seven Egyptian populations. Samples of 814 unrelated individuals from Northern Coast, Delta, Greater Cairo, Canal governorates, Northern Upper Egypt, Southern Upper Egypt, and Sinai were investigated...
August 3, 2018: Biochemical Genetics
Yujing Cheng, Xiaochun Jiang, Jieqiong Jin, Xiongjian Luo, Wanlu Chen, Qi Li, Chan Zhang
Chronic hepatitis B virus (HBV) infection is an important etiology for the development of hepatocellular carcinoma (HCC). Tumor necrosis factor-α-induced protein 3-interacting protein 1 (TNIP1) is linked to specific inflammatory diseases as a novel type of endogenous inflammatory regulator. However, presently, rare information is found about the association between TNIP1 polymorphisms and HBV-induced HCC risk. In this case control study, we genotyped four single nucleotide polymorphisms (SNPs) in TNIP1 gene in 248 HCC patients and 242 chronic HBV carriers using Sequenom Mass-ARRAY technology...
August 2, 2018: Biochemical Genetics
Naindeep Kaur, Jagtar Singh, S Reddy
CAD (Coronary Artery Disease) morbidity is becoming an endemic worldwide. Recently, the role of pro- and anti-inflammatory cytokines in the development of atherosclerotic plaques has been explored, but the association of their genetic polymorphisms and CAD has yet not been established. The present study aimed to investigate the association of IL-8-251A/T (rs4073) and IL-10 -592C/A (rs1800872) polymorphisms and the risk of CAD in North Indian population. 1000 subjects (500 angiographically confirmed CAD patients and 500 controls) were genotyped by ARMS-PCR...
August 2, 2018: Biochemical Genetics
Jing Zhu, Jin-Zhu Luo, Cheng-Bin Li
The aim of this study was to investigate the correlations of an Ins/Del polymorphism (rs10680577) in the RERT-lncRNA with the susceptibility, clinicopathological features, and prognosis of lung cancer. A total of 376 patients with lung cancer and 419 healthy subjects were enrolled in this study. The genotype of rs10680577 was performed using polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Quantitative real-time PCR was used to measure RERT-lncRNA and EGLN2 expressions. Subjects with Del allele of rs10680577 exhibited an elevated risk of lung cancer...
August 2, 2018: Biochemical Genetics
Hao Cui, Jianxin Liu, Guming Xu, Xujiao Ren, Zhenbiao Li, Ying Li, Zhangyong Ning
Ascites syndrome (AS) is a harmful disease in fast-growing broilers characterized by heart failure and serious fluid accumulation in the abdominal cavity. One of the known functions of zinc transporter ZIP12 is an important regulator in pulmonary hypertension (PH) in rat. Whether chicken ZIP12 is involved in the process of AS need to be explored. Here, chicken ZIP12 was sequenced and expression pattern and histological distribution were detected in broilers of AS induced by intravenous cellulose microparticle injection...
August 2, 2018: Biochemical Genetics
Mahrima Parvin, Farhana Jahan, Pankaj Kumar Sarkar, Zakir Hossain Howlader, A H M Nurun Nabi, Md Ismail Hosen
The original version of this article unfortunately contained a mistake in the co-author name. It should be Farhana Jahan instead of Farhan Jahan.
July 30, 2018: Biochemical Genetics
Farzad Fayaz, Mostafa Aghaee Sarbarzeh, Reza Talebi, Amin Azadi
Durum wheat is grown mainly in rain-fed regions of Iran and the Mediterranean district under stressful conditions. Different environmental conditions and agricultural practices among ancient communities have led to the development of locally adapted genotypes known as landraces. Landraces are a valued source of genetic variety and show definite adaptation to local environmental conditions according to their home of origin. This study aimed to explore linkage disequilibrium (LD) analysis and the population structure and genetic diversity of Iranian durum wheat landraces...
July 26, 2018: Biochemical Genetics
Raminderjit Kaur, Jatinder Singh, Rohit Kapoor, Manpreet Kaur
P-selectin, an adhesion molecule, is encoded by SELP and known as biomarker of endothelial as well as platelet dysfunction. SELP polymorphisms (rs6136, rs6127, and rs6125) and raised levels of soluble P-selectin (sP-selectin) have been associated with several disease conditions. The present study was aimed to determine the association of SELP variants and sP-selectin levels as well as vascular risk in Type 2 diabetes mellitus (T2DM) patients. The frequency of rs6136, rs6127, and rs6125 was assessed by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR)...
July 25, 2018: Biochemical Genetics
Sisubalan Natarajan, Priyanka Mishra, Malayaman Vadivel, M Ghouse Basha, Amit Kumar, Sundaresan Velusamy
Rubia cordifolia L., is an industrially viable medicinal crop and is widely exploited for the therapeutic potential of its bioactive metabolite, purpurin. The present investigation aimed to explore the chemotypic and molecular variability in seven wild populations of R. cordifolia from South Eastern Ghats region of India. Thirty-eight individuals were assessed for molecular fingerprinting (ISSR markers) and densitometric quantification of purpurin and alizarin. The populations of Yelagiri Hills and Shervaroy Hills contained the highest levels of alizarin (0...
July 23, 2018: Biochemical Genetics
Zhifeng Xu, Yuqing Han, Chaoying Zhu, Peng Chen, Wei Xu, Luzhang Ruan
Dispersal is a life history trait that has relevant effect on both the dynamics and the genetics of species and sex-biased dispersal depends on how resource competition affects each of the sexes. In this study, a total of 210 blood samples including 121 Common Moorhen (Gallinula chloropus) females and 89 males were collected from 18 diverse areas during the breeding season. Based on 8 microsatellite markers analyses, we found that the most genetic diversities from female populations were higher than those from the males, where only 2 male individuals were identified as the long-distance dispersal...
July 20, 2018: Biochemical Genetics
Manuela Nunes Drehmer, Yara Costa Netto Muniz, Andrea Rita Marrero, Sara Emelie Löfgren
One of the main risk factors for the development of an autoimmune disease is to be a woman. Much attention has been given to the involvement of female hormones in their etiology and sexual bias, although the mechanisms behind this potentially strong contribution in disease susceptibility are poorly understood. ABHD6 gene was recently identified as a risk factor for system lupus erythematosus and the risk was correlated with overexpression of the gene. ABHD6 is an enzyme that degrades the 2-arachidonoylglycerol, an endocannabinoid with immunomodulatory effects...
July 13, 2018: Biochemical Genetics
Mahrima Parvin, Farhana Jahan, Pankaj Kumar Sarkar, Zakir Hossain Howlader, A H M Nurun Nabi, Md Ismail Hosen
Bangladesh has the second largest number of adults with diabetes in South Asia. Compelling evidence suggest that miRNAs contribute to the etiology of Type 2 diabetes mellitus (T2DM) by regulating many aspects of glucose homeostasis. Hence, we hypothesized that genetic polymorphisms in the diabetes-related miRNA target-binding sites could be associated with the risk of T2DM in Bangladesh. The reference Single nucleotide polymorphism (SNP) data from the Insulin Receptor (INSR) gene were downloaded from the ENSEMBL genome browser release 88 and further analyzed in silico for identifying SNPs with deleterious effect and clinical relationships...
July 4, 2018: Biochemical Genetics
Xianguang Yang, Chuncui He, Lin Zhu, Weiming Zhao, Shuaihong Li, Cong Xia, Cunshuan Xu
Notch signaling is closely related to cell proliferation, cell apoptosis, cell fate decisions, DNA damage repair, and so on. However, the exactly regulatory mechanism of Notch signaling pathway in liver regeneration (LR) remains unclear. To reveal the role of Notch signaling pathway in rat liver regeneration, Ingenuity Pathway Analysis (IPA) software and related pathway database were firstly used to construct the Notch signaling pathway in this study. Next, eight type cells with high purity were obtained by Percoll density centrifugation and immunomagnetic beads sorting...
June 30, 2018: Biochemical Genetics
Chenggui Miao, Zhongwen Xie, Jun Chang
In this review, we summarize the current understanding of microRNA (miRNA)-mediated modulation of the gene expression in the fatty liver as well as related signaling pathways. Because of the breadth and diversity of miRNAs, miRNAs may have a very wide variety of biological functions, and much evidence has confirmed that miRNAs are involved in the pathogenesis of fatty liver. In the pathophysiological mechanism of fatty liver, miRNAs may be regulated by upstream regulators, and have their own regulatory targets...
June 27, 2018: Biochemical Genetics
Defang Zhang, Tao Xia, Shaofei Dang, Guanghui Fan, Zhanlin Wang
Chinese wolfberry (Lycium spp.) is an important edible and medicinal plant, with a long cultivation history. The genetic relationships among wild Lycium species and landraces have been unclear for a number of reasons, which has hindered the breeding of modern Chinese wolfberry cultivars. In this study, we collected 19 accessions of Chinese wolfberry germplasm, and constructed the genetic relationship based on RAD-seq markers. We obtained 30.32 Gb of clean data, with the average value of each sample being 1...
June 6, 2018: Biochemical Genetics
Monica Szabó, Beáta Máté, Katalin Csép, Theodora Benedek
With the pandemic of type 2 diabetes (T2D), there is an ever-increasing need to fully understand the underlying mechanisms of the disease. Type 2 diabetes shows a high heritability risk (25-80%); however, genes account only for 10% of this risk. From all the risk factors for diabetes, epigenetic mechanisms have the highest statistical scoring in explaining the disease. A multitude of organ-specific epigenomic changes have been linked to type 2 diabetes. Nutritional influences, mainly in the early life, physical activity level, environmental toxins act as epigenetic factors and the recognized epigenetic changes can represent a therapeutical target, new drugs being currently in development for this application...
June 5, 2018: Biochemical Genetics
Yunyun Jin, Qing Yang, Jiayang Gao, Qi Tang, Bo Duan, Ting Yu, Xinglei Qi, Jiming Liu, Rongmin Wang, Ruihua Dang, Chuzhao Lei, Hong Chen, Xianyong Lan
Growth traits are complex quantitative traits controlled by numerous candidate genes, and they can be well-evaluated using body measurement traits. As the members of the nicotinamide adenine dinucleotide-dependent family of histone deacetylases, class I sirtuin genes (including SIRT1, SIRT2 and SIRT3) play crucial roles in regulating lipid metabolism, cellular growth and metabolism, suggesting that they are potential candidate genes affecting body measurement traits in animals. Hence, the objective of this work aimed to detect novel insertions/deletions (indels) of SIRT1, SIRT2 and SIRT3 genes in 955 cattle belonging to five breeds, as well as to evaluate their effects on body measurement traits...
June 4, 2018: Biochemical Genetics
Sara Aghakhani Chegeni, Mahsa Rahimzadeh, Hossein Montazerghaem, Mahmood Khayatian, Farzaneh Dasturian, Nadereh Naderi
Cardiopulmonary bypass-associated acute kidney injury (CPB-AKI) is a well-recognized complication which is clearly linked to increased morbidity and mortality. Due to important role of inflammation in CPB-AKI pathogenesis, we explored the association between polymorphisms in STAT3, an inflammation-associated transcription factor, and the risk of CPB-AKI. In this study, STAT3 rs1053004 and rs744166 polymorphisms were analyzed in 129 patients undergoing coronary artery bypass grafting in Jorjani heart center, Bandar Abbas, Iran...
May 30, 2018: Biochemical Genetics
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