journal
MENU ▼
Read by QxMD icon Read
search

Biochemical Genetics

journal
https://www.readbyqxmd.com/read/29177636/sequence-analysis-and-comparative-bioinformatics-study-of-camelysin-gene-caly-isolated-from-bacillus-thuringiensis
#1
Fateha Irshad, Zahid Mushtaq, Shakeel Akhtar
Bacillus strains have been widely used for the production of fibrinolytic enzymes having role in the treatment of cardiovascular disorders. Purification and overproduction of such enzymes has increased their usage in medical fields including metalloproteinases with the ability to degrade extracellular matrix (ECM). Camelysin, a neutral metalloproteinase has been isolated from different species of bacteria like Bacillus cereus, Bacillus anthracis, and Bacillus thuringiensis with fibrinolytic, collagenolytic and actin degradation activity...
November 24, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29150723/a-grapevine-inducible-gene-vv-%C3%AE-gal-sip-confers-salt-and-desiccation-tolerance-in-escherichia-coli-and-tobacco-at-germinative-stage
#2
Samia Daldoul, Anis Ben Amar, Mahmoud Gargouri, Hajer Limam, Ahmed Mliki, Thierry Wetzel
Grapevine is an important fruit crop cultivated worldwide. Previously, we have reported the characterization of a salt stress-inducible gene Vv-α-gal/SIP isolated from the tolerant grapevine cultivar Razegui. In this study, we performed functional studies in both Escherichia coli and tobacco systems to gain more insights in the role of the Vv-α-gal/SIP gene. Our data revealed that the recombinant E. coli cells harboring the pET24b(+) expression vector with the Vv-α-gal/SIP showed higher tolerance to desiccation and salinity compared to E...
November 17, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29143896/modulation-of-stimulator-of-interferon-genes-sting-expression-by-interferon-%C3%AE-in-human-keratinocytes
#3
Yohei Nishikawa, Yasushi Matsuzaki, Kazuyuki Kimura, Akiko Rokunohe, Hajime Nakano, Daisuke Sawamura
Infection of microbial pathogen triggers the innate immune system, and the induction of interferons (IFNs) play a vital role in host antiviral response. Stimulator of interferon genes (STING) was identified as a crucial regulator of the DNA sensing pathway, and activates both nuclear factor-κB and interferon regulatory factor 3 transcription pathways to evoke IFNs production. In this study, we studied the upregulation of STING mRNA expression, induced by IFN-γ in human keratinocytes (HaCaT). STING promoter assays clarified that a gamma-activated sequence (GAS), located at - 7 to - 15-bp, is required for IFN-γ-upregulated promoter activity...
November 16, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29143895/genetic-approaches-to-the-study-of-gene-variants-and-their-impact-on-the-pathophysiology-of-type-2-diabetes
#4
REVIEW
Monica Szabo, Beáta Máté, Katalin Csép, Theodora Benedek
Diabetes mellitus is an incurable progressive disease, characterized by elevated blood glucose levels, which lead to the development of micro- and macrovascular complications. Although the etiopathology of the disease remains unclear, it seems to be multifactorial, with an important interaction between genetics and environmental causes. Currently, the genetics of type 2 diabetes (T2D) is poorly understood. The recent advance of the genetic technologies and with a better understanding of genetics, more than 120 distinct genetic loci, with more than 150 variants, have been identified that may be involved in the pathogenesis of T2D...
November 16, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29110115/dnm1l-variant-alters-baseline-mitochondrial-function-and-response-to-stress-in-a-patient-with-severe-neurological-dysfunction
#5
Kaley A Hogarth, Sheila R Costford, Grace Yoon, Neal Sondheimer, Jason T Maynes
Mitochondria play vital roles in brain development and neuronal activity, and mitochondrial dynamics (fission and fusion) maintain organelle function through the removal of damaged components. Dynamin-like protein-1 (DRP-1), encoded by DNM1L, is an evolutionarily conserved GTPase that mediates mitochondrial fission by surrounding the scission site in concentric ring-like structures via self-oligomerization, followed by GTPase-dependant constriction. Here, we describe the clinical characteristics and cellular phenotype of a patient with severe neurological dysfunction, possessing a homozygous DNM1L variant c...
November 6, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29094226/aminoacidopathies-prevalence-etiology-screening-and-treatment-options
#6
REVIEW
Muhammad Wasim, Fazli Rabbi Awan, Haq Nawaz Khan, Abdul Tawab, Mazhar Iqbal, Hina Ayesha
Inborn errors of metabolism (IEMs) are a group of inherited metabolic disorders which are caused by mutations in the specific genes that lead to impaired proteins or enzymes production. Different metabolic pathways are perturbed due to the deficiency or lack of enzymes. To date, more than 500 IEMs have been reported with most of them being untreatable. However, fortunately 91 such disorders are potentially treatable, if diagnosed at an earlier stage of life. IEMs have been classified into different categories and one class of IEMs, characterized by the physiological disturbances of amino acids is called as aminoacidopathies...
November 1, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29124522/retraction-note-to-potential-start-codon-targeted-scot-and-interretrotransposon-amplified-polymorphism-irap-markers-for-evaluation-of-genetic-diversity-and-conservation-of-wild-pistacia-species-population
#7
Karim Sorkheh, Nazanin Amirbakhtiar, Sezai Ercisli
"This article has been retracted by the Publisher in agreement with the Editor-in-Chief, because it contains portions of writings on the same topic already published and without sufficient attribution to these earlier works being given. The principal authors of the paper acknowledged that text from background sources was mistakenly used in this article without proper reference to the original source. Upon investigation carried out according to the Committee on Publication Ethics guidelines, it has been found that the authors have duplicated or rephrased parts from other articles of which the main sources...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29094225/effect-of-zinc-and-melatonin-on-oxidative-stress-and-serum-inhibin-b-levels-in-a-rat-testicular-torsion-detorsion-model
#8
Atilla Semercioz, Abdulkerim Kasim Baltaci, Rasim Mogulkoc, Mustafa Cihat Avunduk
The present study was aimed to examine the effects of 3-week zinc and melatonin administration on testicular tissue injury and serum Inhibin-B levels caused by unilateral testicular torsion-detorsion in rats. The study was performed on 60 Wistar Albino-type adult male rats. The animals were allocated to 6 groups in equal numbers. 1. Control; 2. Sham; 3. Ischemia-reperfusion; 4. Zinc + ischemia-reperfusion; 5. Melatonin + ischemia-reperfusion; 6. Zinc + melatonin + ischemia-reperfusion. Zinc and melatonin were administered before ischemia-reperfusion at doses of 5 and 3 mg/kg respectively, by intraperitoneal route for a period of 3 weeks...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/29086887/genetic-testing-of-non-familial-deaf-patients-for-cib2-and-gjb2-mutations-phenotype-and-genetic-counselling
#9
Hina Shaikh, Ali M Waryah, Ashok K Narsani, Muhammad Iqbal, Mohsin Shahzad, Yar M Waryah, Naila Shaikh, Amber Mahmood
CIB2 and GJB2 genes variants contribute significantly in familial cases of prelingual recessive hearing loss (HL). This study was aimed to determine the CIB2 and GJB2 variants and associated phenotype in 150 non-familial individuals with HL. After getting informed consent, 150 non-familial deaf patients were enrolled and blood samples were obtained for DNA extraction. Pure tone air conduction audiometry was performed. Coding exons of CIB2 and GJB2 genes were Sanger sequenced. A tetra primer ARMS assay was developed for recurrent CIB2 variant...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28664349/the-effect-of-citrulline-malate-on-blood-lactate-levels-in-intensive-exercise
#10
Fatih Kiyici, Hüseyin Eroğlu, N Fazil Kishali, Guleda Burmaoglu
The purpose of this study was to examine the effects of Citrulline/Malate supplementation with intensive training on blood lactate level in active handball players. The athletes were subjected to intense training for 4 weeks, 4 days a week, mainly pre-season strength and technique training. In this training period, stimol group (n = 11) athletes were given stimol 3 times a day as 1 g for breakfast, 1 g for lunch, and 1 g for dinner while the placebo group (n = 11) athletes were given only placebo in the same dosage and the same color at the same time...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28639055/effects-of-kaolin-m-99-099-application-on-antioxidant-and-phenolic-compounds-in-tea-leaves-camellia-sinensis-l-o-kuntze
#11
Keziban Yazici, Burcu Goksu
In this study, the effects of kaolin (M-99-099) applications on the total phenolic and antioxidant contents of tea leaves (Camellia sinensis (L.) O. Kuntze) harvested in three different periods were investigated. For this purpose, four different strategies including standard fertilizer application (T), 3% kaolin+standard fertilizer application (Ka1), 6% kaolin+standard fertilizer application (Ka2), and control (C) (nothing applied) were used to compare the effects of these strategies on total phenolic content, FRAP values, and DPPH radical scavenging capacities of tea leaves...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28639054/a-strong-relationship-between-oral-squamous-cell-carcinoma-and-dna-repair-genes
#12
Hakan Avci, Arzu Ergen, Elif Sinem Bireller, Baris Ertugrul, Bedia Cakmakoglu
Single nucleotide polymorphisms of DNA repair genes alter protein function and modulate DNA repair efficiency in various cancers. The X-ray repair cross-complementing group (XRCC) is responsible for the repair of DNA base damage and single-strand breaks. The aim of our study was to investigate the association of XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms with the susceptibility to develop oral squamous cell carcinoma (OSCC) in Turkish subjects. One hundred eleven patients with OSCC and 148 healthy controls were recruited for the study...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28478603/genetic-diversity-in-various-accessions-of-pineapple-ananas-comosus-l-merr-using-issr-and-ssr-markers
#13
Jian-Sheng Wang, Jun-Hu He, Hua-Rui Chen, Ye-Yuan Chen, Fei Qiao
Inter simple sequence repeat (ISSR) and simple sequence repeat (SSR) markers were used to assess the genetic diversity of 36 pineapple accessions that were introduced from 10 countries/regions. Thirteen ISSR primers amplified 96 bands, of which 91 (93.65%) were polymorphic, whereas 20 SSR primers amplified 73 bands, of which 70 (96.50%) were polymorphic. Nei's gene diversity (h = 0.28), Shannon's information index (I = 0.43), and polymorphism information content (PIC = 0.29) generated using the SSR primers were higher than that with ISSR primers (h =  0...
December 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28466379/bayesian-and-phylogenic-approaches-for-studying-relationships-among-table-olive-cultivars
#14
Rayda Ben Ayed, Karim Ennouri, Fathi Ben Amar, Fabienne Moreau, Mohamed Ali Triki, Ahmed Rebai
To enhance table olive tree authentication, relationship, and productivity, we consider the analysis of 18 worldwide table olive cultivars (Olea europaea L.) based on morphological, biological, and physicochemical markers analyzed by bioinformatic and biostatistic tools. Accordingly, we assess the relationships between the studied varieties, on the one hand, and the potential productivity-quantitative parameter links on the other hand. The bioinformatic analysis based on the graphical representation of the matrix of Euclidean distances, the principal components analysis, unweighted pair group method with arithmetic mean, and principal coordinate analysis (PCoA) revealed three major clusters which were not correlated with the geographic origin...
August 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28425009/the-molecular-genetic-expression-as-a-novel-biomarker-in-the-evaluation-and-monitoring-of-patients-with-osteosarcoma-subtype-bone-cancer-disease
#15
REVIEW
Delia Hutanu, Roxana Popescu, Horatiu Stefanescu, Laurentiu Pirtea, Adrian Candea, Cristi Sarau, Ovidiu Boruga, Lagtonbi Mehdi, Ioana Ciuca, Sonia Tanasescu
One of the leading causes of death among patients with malignancies is represented by bone cancer. According to current studies, the leading cause of death among these patients is represented by late diagnosis, poor response to therapy, and the lack of accuracy in terms of clinical evaluation. In this regard, there have been developed a series of methods of diagnosis and evaluation, the most investigated being represented by miRNA expression. In this updated work, we want to present a series of changes in the expression of miRNAs in bone cancer...
August 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28421310/comparison-of-selected-protein-levels-in-tumour-and-surgical-margin-in-a-group-of-patients-with-oral-cavity-cancer
#16
Joanna Katarzyna Strzelczyk, Karolina Gołąbek, Piotr Cuber, Łukasz Krakowczyk, Aleksander Jerzy Owczarek, Martyna Fronczek, Piotr Choręża, Edyta Hudziec, Zofia Ostrowska
Oral cavity cancer belongs to head-and-neck squamous cell carcinoma group. The purpose of the study was to assess the levels of certain proteins in a tumour and surgical margin in a group of patients with oral cavity cancer. The levels of DAPK1, MGMT, CDH1, SFRP1, SFRP2, RORA, TIMP3, p16, APC and RASSF1 proteins were measured by ELISA in tissue homogenates. The protein levels of DAPK1, MGMT, CDH1, SFRP2 and RASSF1 were significantly higher in tumour tissue than in the margin, contrary to TIMP3 which was lower in the tumour itself...
August 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28389737/paraoxonase-and-arylesterase-levels-in-behcet-s-disease-and-their-relations-with-the-disease-activity
#17
Ayhan Kul, Hulya Uzkeser, Nurinnisa Ozturk
The aim of this study was to determine the paraoxonase (PON) and arylesterase (ARE) enzyme activity levels in Behcet's disease (BD) and to investigate whether they are associated with the disease activity. Twenty-six patients (study group) with active BD and 28 healthy controls (control group) were included in this study. While the patients who had at least one of the symptoms related to genital ulcer, skin lesions, active uveitis, arthritis, thrombophlebitis, or central nervous system involvement in addition to oral ulcers were considered as the active group, the patients who did not show clinical symptoms in the last one month due to the medical treatment were considered as the inactive group in the clinical evaluation of patients with BD...
August 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28303356/the-association-of-plasminogen-activator-inhibitor-type-1-pai-1-level-and-pai-1-4g-5g-gene-polymorphism-with-the-formation-and-the-grade-of-endometrial-cancer
#18
Malik Ejder Yıldırım, Savas Karakuş, Hande Küçük Kurtulgan, Hasan Kılıçgün, Serpil Erşan, Sevtap Bakır
Plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor (Serpine 1), and it inhibits both tissue plasminogen activator and urokinase plasminogen activator which are important in fibrinolysis. We aimed to find whether there is a possible association between PAI-1 level, PAI-1 4G/5G polymorphism, and endometrial cancer. PAI-1 levels in peripheral blood were determined in 82 patients with endometrial carcinoma and 76 female healthy controls using an enzyme-linked immunoassay (ELISA). Then, the genomic DNA was extracted and screened by reverse hybridization procedure (Strip assay) to detect PAI 1 4G/5G polymorphism...
August 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28070693/micrornas-expression-as-novel-genetic-biomarker-for-early-prediction-and-continuous-monitoring-in-pulmonary-cancer
#19
REVIEW
Razvan Nitu, Alexandru Florin Rogobete, Fuat Gundogdu, Sonia Tanasescu, Ovidiu Boruga, Adriana Sas, Sonia Elena Popovici, Delia Hutanu, Ciprian Pilut, Cristian Andrei Sarau, Adrian Constantin Candea, Adrian Tudor Stan, Liviu Marius Moise
One of the main causes of death in the world is lung cancer. According to the World Health Organization, the annual incidence of lung cancer increases significantly. Moreover, lung cancer accounts for one of the highest mortality rates, mainly due to late detection. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis and for monitoring and evaluation of lung cancer stages. An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer...
August 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/27704306/retracted-article-peroxidase-gene-based-estimation-of-genetic-relationships-and-population-structure-among-wild-pistacia-species-populations
#20
Setareh Mirzavand, Karim Sorkheh, Mohammad Reza Siahpoosh
No abstract text is available yet for this article.
August 2017: Biochemical Genetics
journal
journal
21782
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"