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Biochemical Genetics

Alfredo Vázquez-Ovando, Héctor Escalona-Buendía, Isidro Ovando-Medina, Miguel Salvador-Figueroa
The sensory properties of cacao beans are linked to the chemical composition of the seeds, and both characteristics are the partial results of its allelic composition. Therefore, it is useful to search for molecular markers associated with these traits. We perform multiple regression analysis to associate previously generated data of alleles generated with 12 SSR (of cultivated cacao trees) with data obtained from chemical and sensory characterization (of beans) of plants grown in the southern region from Mexico...
October 3, 2018: Biochemical Genetics
Ergün Sönmezgöz, Samet Özer, Ali Gül, Resul Yılmaz, Tuba Kasap, Şahin Takcı, Rüveyda Gümüşer, Osman Demir
The present study examined the relationship between clinical findings and mutation analyses in children with Familial Mediterranean Fever (FMF) in the inner Black Sea region of Turkey. This retrospective, cross-sectional study included patients with FMF who were evaluated between 2007 and 2015. FMF was diagnosed according to the Tel Hashomer criteria. FMF mutations were analyzed using a Real-time PCR System (Roche Diagnostics, Mannheim, Germany), and patients were classified into three groups according to allele status...
October 3, 2018: Biochemical Genetics
Mi Su, Yan Jun Si, Qi Wei Guo, Mei Yang, Xu Chen, Jia Lin, Ding Zhi Fang
Posttraumatic stress disorder (PTSD) and growth hormone secretagogue receptor (GHSR) were reported to be associated with plasma lipid and glucose levels. However, interplays of PTSD with GHSR on plasma lipid and glucose levels have not been explored yet. This study was to investigate the interplays of PTSD and GHSR rs495225 on plasma glucose and lipid profiles. A total of 709 high school students were recruited at 6 months after the 2008 Wenchuan earthquake. Variants of GHSR rs495225 were identified by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing...
September 29, 2018: Biochemical Genetics
Muhammad Amjad Nawaz, Xiao Lin, Ting-Fung Chan, Muhammad Imtiaz, Hafiz Mamoon Rehman, Muhammad Amjad Ali, Faheem Shehzad Baloch, Rana Muhammad Atif, Seung Hwan Yang, Gyuhwa Chung
Cellulose synthase A (CESA) is a key enzyme involved in the complex process of plant cell wall biosynthesis, and it remains a productive subject for research. We employed systems biology approaches to explore structural diversity of eudicot CESAs by exon-intron organization, mode of duplication, synteny, and splice site analyses. Using a combined phylogenetics and comparative genomics approach coupled with co-expression networks we reconciled the evolution of cellulose synthase gene family in eudicots and found that the basic forms of CESA proteins are retained in angiosperms...
September 28, 2018: Biochemical Genetics
Xianhua Wu, Yongsheng Gong, Xuebing Ding, Gang Cheng, Weiya Yan, Xiaowei She, Changxing Wang, Xia Li
Tissue-type plasminogen activator (tPA) is involved in the lysis of blood clots. In this study, we attempted to target thrombolysis and enhance blood clot lysis by generating a construct (pLEGFP-N1-tPA) to integrate tPA gene into the genome of different cell lines. pLEGFP-N1-tPA construct was generated and used to target the tPA gene in different cell lines. The thrombolytic effects mediated by the supernatant from transfected HeLa cells and Linx cells were assessed using plasma thrombus plates. Furthermore, enhanced green fluorescent protein (EGFP), which was fused to the tPA gene in the pLEGFP-N1-tPA construct, was analyzed under the fluorescent microscope to assess tPA localization...
September 14, 2018: Biochemical Genetics
Dina M Abo-Elmatty, Eman T Mehanna
Preeclampsia and gestational diabetes are common pregnancy disorders that may be interrelated. MIR146A rs2910164 (G/C) is a functional polymorphism that was associated with several diseases. This study aimed to investigate the frequency of rs2910164 polymorphism and its possible correlation with the incidence of preeclampsia in gestational diabetes patients. The study involved 250 pregnant women divided into 80 healthy control subjects, 85 gestational diabetes patients only, and 85 patients of gestational diabetes combined with preeclampsia...
August 18, 2018: Biochemical Genetics
Majede Rezaei, Mostafa Saadat
Relationship between glutathione S-transferase P1 (GSTP1, OMIM: 134660) variants and the risk of drug dependency is unknown. Chronic use of illegal drugs leads to oxidative stress, which can be alleviated by cellular detoxification mechanisms. There are several polymorphisms in the GSTP1, including Ile105Val (rs1695). This polymorphism leads to an Ile105Val amino acid change and may alter the GSTP1 enzyme activity. There is no study on the association between this polymorphism and risks of heroin (HD) or opium (OD) dependency...
August 18, 2018: Biochemical Genetics
Saeid Tamadoni Jahromi, Ahmad Sofiman Othman, Rusly Rosazlina
There are two morphotypes of Penaeus semisulcatus described hitherto in the Persian Gulf, namely the banded and non-banded antennae morphotypes. In this study, we used morphometric measurements and two mitochondrial genes (16S rRNA and cytochrome oxidase subunit I-COI) to assess relationships between the two morphotypes of P. semisulcatus. Out of 25 morphological characters examined, 10 characters were found significantly different between the two morphotypes when tested against separate sexes or both sexes combined...
August 12, 2018: Biochemical Genetics
Ahmed F AbdEl-Hafez, Sherif H El-Alfy, Hamdy H Swelim, Nagwa H A Hassan
Egypt is a transcontinental country containing substantial ethnic, cultural, and linguistic diversity among its people. This study was conducted to investigate the genetic variation at 15 AmpFlSTR Identifiler short tandem repeat (STR) loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA, within and between seven Egyptian populations. Samples of 814 unrelated individuals from Northern Coast, Delta, Greater Cairo, Canal governorates, Northern Upper Egypt, Southern Upper Egypt, and Sinai were investigated...
August 3, 2018: Biochemical Genetics
Yujing Cheng, Xiaochun Jiang, Jieqiong Jin, Xiongjian Luo, Wanlu Chen, Qi Li, Chan Zhang
Chronic hepatitis B virus (HBV) infection is an important etiology for the development of hepatocellular carcinoma (HCC). Tumor necrosis factor-α-induced protein 3-interacting protein 1 (TNIP1) is linked to specific inflammatory diseases as a novel type of endogenous inflammatory regulator. However, presently, rare information is found about the association between TNIP1 polymorphisms and HBV-induced HCC risk. In this case control study, we genotyped four single nucleotide polymorphisms (SNPs) in TNIP1 gene in 248 HCC patients and 242 chronic HBV carriers using Sequenom Mass-ARRAY technology...
August 2, 2018: Biochemical Genetics
Naindeep Kaur, Jagtar Singh, S Reddy
CAD (Coronary Artery Disease) morbidity is becoming an endemic worldwide. Recently, the role of pro- and anti-inflammatory cytokines in the development of atherosclerotic plaques has been explored, but the association of their genetic polymorphisms and CAD has yet not been established. The present study aimed to investigate the association of IL-8-251A/T (rs4073) and IL-10 -592C/A (rs1800872) polymorphisms and the risk of CAD in North Indian population. 1000 subjects (500 angiographically confirmed CAD patients and 500 controls) were genotyped by ARMS-PCR...
August 2, 2018: Biochemical Genetics
Jing Zhu, Jin-Zhu Luo, Cheng-Bin Li
The aim of this study was to investigate the correlations of an Ins/Del polymorphism (rs10680577) in the RERT-lncRNA with the susceptibility, clinicopathological features, and prognosis of lung cancer. A total of 376 patients with lung cancer and 419 healthy subjects were enrolled in this study. The genotype of rs10680577 was performed using polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Quantitative real-time PCR was used to measure RERT-lncRNA and EGLN2 expressions. Subjects with Del allele of rs10680577 exhibited an elevated risk of lung cancer...
August 2, 2018: Biochemical Genetics
Hao Cui, Jianxin Liu, Guming Xu, Xujiao Ren, Zhenbiao Li, Ying Li, Zhangyong Ning
Ascites syndrome (AS) is a harmful disease in fast-growing broilers characterized by heart failure and serious fluid accumulation in the abdominal cavity. One of the known functions of zinc transporter ZIP12 is an important regulator in pulmonary hypertension (PH) in rat. Whether chicken ZIP12 is involved in the process of AS need to be explored. Here, chicken ZIP12 was sequenced and expression pattern and histological distribution were detected in broilers of AS induced by intravenous cellulose microparticle injection...
August 2, 2018: Biochemical Genetics
Mahrima Parvin, Farhana Jahan, Pankaj Kumar Sarkar, Zakir Hossain Howlader, A H M Nurun Nabi, Md Ismail Hosen
The original version of this article unfortunately contained a mistake in the co-author name. It should be Farhana Jahan instead of Farhan Jahan.
July 30, 2018: Biochemical Genetics
Farzad Fayaz, Mostafa Aghaee Sarbarzeh, Reza Talebi, Amin Azadi
Durum wheat is grown mainly in rain-fed regions of Iran and the Mediterranean district under stressful conditions. Different environmental conditions and agricultural practices among ancient communities have led to the development of locally adapted genotypes known as landraces. Landraces are a valued source of genetic variety and show definite adaptation to local environmental conditions according to their home of origin. This study aimed to explore linkage disequilibrium (LD) analysis and the population structure and genetic diversity of Iranian durum wheat landraces...
July 26, 2018: Biochemical Genetics
Raminderjit Kaur, Jatinder Singh, Rohit Kapoor, Manpreet Kaur
P-selectin, an adhesion molecule, is encoded by SELP and known as biomarker of endothelial as well as platelet dysfunction. SELP polymorphisms (rs6136, rs6127, and rs6125) and raised levels of soluble P-selectin (sP-selectin) have been associated with several disease conditions. The present study was aimed to determine the association of SELP variants and sP-selectin levels as well as vascular risk in Type 2 diabetes mellitus (T2DM) patients. The frequency of rs6136, rs6127, and rs6125 was assessed by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR)...
July 25, 2018: Biochemical Genetics
Sisubalan Natarajan, Priyanka Mishra, Malayaman Vadivel, M Ghouse Basha, Amit Kumar, Sundaresan Velusamy
Rubia cordifolia L., is an industrially viable medicinal crop and is widely exploited for the therapeutic potential of its bioactive metabolite, purpurin. The present investigation aimed to explore the chemotypic and molecular variability in seven wild populations of R. cordifolia from South Eastern Ghats region of India. Thirty-eight individuals were assessed for molecular fingerprinting (ISSR markers) and densitometric quantification of purpurin and alizarin. The populations of Yelagiri Hills and Shervaroy Hills contained the highest levels of alizarin (0...
July 23, 2018: Biochemical Genetics
Zhifeng Xu, Yuqing Han, Chaoying Zhu, Peng Chen, Wei Xu, Luzhang Ruan
Dispersal is a life history trait that has relevant effect on both the dynamics and the genetics of species and sex-biased dispersal depends on how resource competition affects each of the sexes. In this study, a total of 210 blood samples including 121 Common Moorhen (Gallinula chloropus) females and 89 males were collected from 18 diverse areas during the breeding season. Based on 8 microsatellite markers analyses, we found that the most genetic diversities from female populations were higher than those from the males, where only 2 male individuals were identified as the long-distance dispersal...
July 20, 2018: Biochemical Genetics
Chenggui Miao, Zhongwen Xie, Jun Chang
The original version of this article unfortunately contained an error in the Acknowledgement section. The corrected text has been given below.
October 2018: Biochemical Genetics
Chenggui Miao, Zhongwen Xie, Jun Chang
In this review, we summarize the current understanding of microRNA (miRNA)-mediated modulation of the gene expression in the fatty liver as well as related signaling pathways. Because of the breadth and diversity of miRNAs, miRNAs may have a very wide variety of biological functions, and much evidence has confirmed that miRNAs are involved in the pathogenesis of fatty liver. In the pathophysiological mechanism of fatty liver, miRNAs may be regulated by upstream regulators, and have their own regulatory targets...
October 2018: Biochemical Genetics
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