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Biochemical Genetics

Burhanettin İmrak, Ali Küden, Veyis Yurtkulu, Ebru Kafkas, Sezai Ercişli, Salih Kafkas
In this study, promising candidates of six apricot genotypes were compared with our local and major cultivar (Hacıhaliloğlu) based on their phenological, pomological, and biochemical characteristics. Fruit weight, stone weight, flesh firmness, flesh fruit/stone ratio, TSS (Total soluble solids), glucose, fructose, sucrose, total phenols, total antioxidant activity (FRAP and ABTS assays) and bud break, first bloom, full bloom, and harvesting date of apricot cultivar candidates were compared with cultivar Hacıhaliloğlu 'HH...
February 10, 2017: Biochemical Genetics
Abdulkerim Kasım Baltaci, Rasim Mogulkoc
Since zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats...
January 17, 2017: Biochemical Genetics
Takashi Shimizu, Yurie Kawasaki, Yuka Aoki, Fumie Magata, Chiho Kawashima, Akio Miyamoto
In dairy cows, inflammatory diseases caused by infection with pathogenic bacteria post calving affect ovarian functions. This study examined the relationship between single-nucleotide polymorphisms (SNPs) of Toll-like receptor 4 (TLR4), reproductive performances [the number of artificial insemination (AI) application and days open], and immune cell functions (apoptosis and migration). Two hundred Holstein cows from the Obihiro University farm were included. The SNPs of TLR4 were genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP) method...
January 16, 2017: Biochemical Genetics
Florin G Horhat, Fuat Gundogdu, Laurentiu V David, Eugen S Boia, Laurentiu Pirtea, Razvan Horhat, Alexandru Cucui-Cozma, Ioana Ciuca, Mircea Diaconu, Razvan Nitu, Monica Licker, Delia I Horhat, Alexandru F Rogobete, Marius L Moise, Calin Tataru
A high percentage of critical patients are found to develop acute respiratory distress syndrome (ARDS). Several studies have reported high mortality rates in these cases which are most frequently associated with multiple organ dysfunctions syndrome. Lately, many efforts have been made to evaluate and monitor ARDS in critical patients. In this regard, the assessment of genetic polymorphisms responsible for developing ARDS present as a challenge and are considered future biomarkers. Early detection of the specific polymorphic gene responsible for ARDS in critically ill patients can prove to be a useful tool in the future, able to help decrease the mortality rates in these cases...
January 9, 2017: Biochemical Genetics
Razvan Nitu, Alexandru Florin Rogobete, Fuat Gundogdu, Sonia Tanasescu, Ovidiu Boruga, Adriana Sas, Sonia Elena Popovici, Delia Hutanu, Ciprian Pilut, Cristian Andrei Sarau, Adrian Constantin Candea, Adrian Tudor Stan, Liviu Marius Moise
One of the main causes of death in the world is lung cancer. According to the World Health Organization, the annual incidence of lung cancer increases significantly. Moreover, lung cancer accounts for one of the highest mortality rates, mainly due to late detection. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis and for monitoring and evaluation of lung cancer stages. An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer...
January 9, 2017: Biochemical Genetics
Vlad Laurentiu David, Muhammed Furkan Ercisli, Alexandru Florin Rogobete, Eugen S Boia, Razvan Horhat, Razvan Nitu, Mircea M Diaconu, Laurentiu Pirtea, Ioana Ciuca, Delia Horhat, Florin George Horhat, Monica Licker, Sonia Elena Popovici, Sonia Tanasescu, Calin Tataru
Several diagnostic methods for the evaluation and monitoring were used to find out the pro-inflammatory status, as well as incidence of sepsis in critically ill patients. One such recent method is based on investigating the genetic polymorphisms and determining the molecular and genetic links between them, as well as other sepsis-associated pathophysiologies. Identification of genetic polymorphisms in critical patients with sepsis can become a revolutionary method for evaluating and monitoring these patients...
December 9, 2016: Biochemical Genetics
Fatma Yıldırım, Adnan Nurhan Yıldırım, Gülcan Özkan, Bekir Şan, Mehmet Polat, Hatice Aşık, Yaşar Karakurt, Sezai Ercişli
The study was conducted to determine the effects of cultivar, harvest period, and their interaction on the hydrophilic phenolic components extra virgin olive oils of the cultivars 'Ayvalık,' 'Memecik,' and 'Topakaşı.' Olives were collected at three different harvesting periods: (1) early harvest period-1 (Beginning of spotting), (2) early harvest period-2 (End of spotting), and (3) optimum harvest period. Oils were extracted using the Abencor system. HPLC (High-performance liquid chromatograph) technique was used to quantify the phenolic compounds including tyrosol (p-HPEA), hydroxytyrosol (3,4-DHPEA), luteolin, rutin, quercetin, catechin, sinapinic acid, p-coumaric acid, cinnamic acid, vanillin, vanillic acid, ferulic acid, and gallic acid...
December 2, 2016: Biochemical Genetics
L Agnello, C Scazzone, B Lo Sasso, C Bellia, G Bivona, S Realmuto, F Brighina, R Schillaci, P Ragonese, G Salemi, Marcello Ciaccio
Multiple sclerosis (MS) is a chronic demyelinating disease of central nervous system regarded as one of the most common causes of neurological disability in young adults. The exact etiology of MS is not yet known, although epidemiological data indicate that both genetic susceptibility and environmental exposure are involved. A poor vitamin D status has been proposed as the most attractive environmental factor. Several evidence have highlighted the importance of mutations in vitamin D-regulating genes for vitamin D status...
November 30, 2016: Biochemical Genetics
Deniz Kanca, Uzay Gormus, Bengu Tokat, Allison P Eronat, Zehra Bugra, Oğuz Ozturk, Hulya Yilmaz-Aydogan
Recently, subfraction analysis of serum low density lipoprotein (LDL) is considered to be a better predictor of the risk of coronary heart disease (CHD) compared to the other lipid parameters. The aim of this study was to examine the effects of the HDL-associated Taq1B (rs708272) SNP of cholesterol ester transfer protein (CETP) gene on serum LDL subfractions in patients with CHD. Serum lipid levels were measured enzymatically and LDL subfraction analysis was carried out by the Lipoprint System (Quantimetrix, CA, USA)...
November 30, 2016: Biochemical Genetics
Nazila Fathi Maroufi, Khadijeh Farzaneh, Mahdi Alibabrdel, Leila Zarei, Omid Cheraghi, Sina Soltani, Soheila Montazersaheb, Maryam Akbarzadeh, Mohammad Nouri
The metabolic syndrome (MetS) is one of the most important risk factors for type 2 diabetes and cardiovascular disease. This syndrome is characterized by abdominal obesity, hypertension, insulin resistance, and dyslipidemia. The plasma origin of Cholesteryl ester transfer protein (CETP) is responsible for transferring cholesterol esters from high-density lipoprotein particles to apolipoprotein B containing lipoproteins compartment. We conducted this study to investigate the association between CETP gene Taq1B (rs708272) polymorphism in the metabolic syndrome among Iranian subjects...
December 2016: Biochemical Genetics
Amir Nejad-Moghaddam, Sohiela Ajdary, Eisa Tahmasbpour, Farhad Riazi Rad, Yunes Panahi, Mostafa Ghanei
Oxidative stress and inflammation are one of the main pathological consequences of sulfur mustard on human lungs. Unfortunately, there is no effective treatment to mitigate pathological effects of sulfur mustard in mustard lungs. Here, we aimed to evaluate potential efficacy of systemic mesenchymal stem cells administration on expression of oxidative stress- and inflammation-related genes in sulfur mustard-exposed patients. Our patient received 100 million cells per injection, which was continued for four injections within 2 months...
December 2016: Biochemical Genetics
Samet Özer, Resul Yilmaz, Ergün Sonmezgoz, Şeyma Ünuvar, Ömer Ates
Familial Mediterranean fever (FMF) is an autosomal recessively inherited disease characterized by recurrent self-limited attacks of fever accompanied by aseptic inflammation of serosal spaces, joints and skin, peritonitis, pleuritis, and arthritis. Clinical features differ according to genetics variants. The aim of this study was to identify relationship between IL-6 -174G/C gene polymorphisms and clinical features, disease severity score (DSS) and proteinuria in children diagnosed with FMF. In this study, 99 children who were followed-up in Gaziosmanpasa University Medical Faculty Department of Pediatrics and diagnosed with Familial Mediterranean fever according to Tel-Hashomer criteria were included...
December 2016: Biochemical Genetics
Lavinia Melania Bratu, Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Sonia Tanasescu, Razvan Nitu, Sonia Elena Popovici, Zorin Petrisor Crainiceanu
The patient with severe burns always represents a challenge for the trauma team due to the severe biochemical and physiopathological disorders. Although there are many resuscitation protocols of severe burn patient, systemic inflammatory response, oxidative stress, decreased immune response, infections, and multiple organ dysfunction syndromes are still secondary complications of trauma, present at maximum intensity in this type of patients. Currently there are numerous studies regarding the evaluation, monitoring, and minimizing the side effects induced by free radicals through antioxidant therapy...
December 2016: Biochemical Genetics
Kahraman Gürcan, Saffet Teber, Sezai Ercisli, Kadir Uğurtan Yilmaz
Genotyping by sequencing (GBS), which is a highly promising technique for molecular breeding, has been implemented in apricots, including Turkish, European, and Plum Pox Virus-resistant accessions. DNA samples were digested with the ApeKI restriction enzyme to construct a genome-complexity-reduced 90-plex GBS library. After filtering the raw sequences, approximately 28 G of clean data were generated, and 17,842 high-quality single-nucleotide polymorphism (SNP) loci were discovered. A total of 561 SNP loci with 0 or 1 missing reads for the 90 accessions produced 1162 markers that were used for the cluster and population structure analysis of the same collection...
December 2016: Biochemical Genetics
Ebru Sakar, Hulya Unver, Sezai Ercisli
Olive (Olea europaea) is an ancient and important crop in both olive oil production and table use. It is important to identify the genetic diversity of olive genetic resources for cultivar development and evaluation of olive germplasm. In the study, 14 microsatellite markers (UDO4, UDO8, UDO9, UDO11, UDO12, UDO22, UDO24, UDO26, UDO28, DCA9, DCA11, DCA13, DCA15, and DCA18) were used to assess the genetic variation on 76 olive (Olea europaea L.) genotypes from Mardin province together with 6 well-known Turkish and 4 well-known foreign reference cultivars...
December 2016: Biochemical Genetics
Tun-Jen Hsiao, Eugene Lin
Previous data suggesting that a single nucleotide polymorphism (SNP), rs266729, in the adiponectin C1Q and collagen domain containing (ADIPOQ) gene was associated with type 2 diabetes (T2D) have been inconsistent, especially in Asian populations. In this replication study, we aimed to reassess whether the ADIPOQ rs266729 SNP is associated with T2D, obesity, and T2D/obesity-related metabolic traits in a Taiwanese population. A total of 1047 Taiwanese subjects were analyzed. The ADIPOQ rs266729 SNP was genotyped by the Taqman assay...
December 2016: Biochemical Genetics
Oztas Ezgi, Arici Merve, Yanar Teoman Hakan, Özhan Gül
Colorectal cancer (CRC) is the third most common cause of cancer-related mortality and causes almost a million deaths worldwide each year. Genetic and environmental factors have gained importance in CRC as well as other types of cancer due to contribution to development of malignancies. Phosholipase C-epsilon 1 PLCE1 is one of the phospholipase family of enzymes and controls cellular responses leading to cell growth, differentiation and gene expression. Therefore, it was evaluated the effects of PLCE1 variations on developing CRC...
December 2016: Biochemical Genetics
Rajdeep Das, Gopa Mitra, Boby Mathew, Vijay Bhat, Cecil Ross, Debnath Pal, Amit Kumar Mandal
Hemoglobinopathies are caused by point mutation in globin gene that results in structural variant of hemoglobin. While 7 % of world populations are carrier of hemoglobinopathies, the prevalence of the disease varies between 3 to 17 % across different population groups in India. In a diagnostic laboratory, alkaline gel electrophoresis and cation exchange-based HPLC (CE-HPLC) are most widely used techniques for characterization of hemoglobin variants. In the above methods, the differential surface charge of hemoglobin molecule in variants is exploited for their characterization...
December 2016: Biochemical Genetics
Mete Bora Tüzüner, Tülin Öztürk, Allison Pınar Eronat, Fatih Seyhan, Halil İbrahim Kısakesen, Zerrin Calay, Şennur İlvan, Hande Turna, Hülya Yılmaz-Aydoğan, Hakan Bermek, Oğuz Öztürk
There is growing attention focused on local estrogen production in the breast tissue and its possible role in breast cancer initiation and progression. Understanding the underlying mechanisms for estrogen synthesis and the microenvironment consisting of tumor and its surrounding adipose tissue might open new avenues in breast cancer prevention, prognosis and treatment. In order to obtain insight, we compared peritumoral and tumor tissue expressions of CYP17A1 and CYP19A1 genes, which play an important role in estrogen biosynthesis...
December 2016: Biochemical Genetics
Harun Alp, Neslihan Pinar, Recep Dokuyucu, Mustafa Sahan, Cem Oruc, Ibrahim Kaplan, Serkan Senol, Ayse Bahar Ceyran
The present study was aimed to the investigate the protective effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity and pancreatic injury caused by acute dichlorvos (D) intoxication in rats. Forty-eight Wistar rats were randomly divided into seven groups each containing seven rats except control groups. The groups included control, D, CAPE, IL, D + CAPE, D + IL, and D + CAPE + IL. Total antioxidant status and total oxidative stress levels were measured by automated colorimetric assay...
December 2016: Biochemical Genetics
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