journal
MENU ▼
Read by QxMD icon Read
search

Advances in Experimental Medicine and Biology

journal
https://www.readbyqxmd.com/read/29464659/embryonic-stem-cells-in-development-and-regenerative-medicine
#1
Ayşegül Doğan
After progressive improvement in embryonic stem (ES) cell field, several studies have been conducted to explore the usage of ES cells in regenerative medicine. Unlimited self renewal and pluripoteny properties, combined with encouraging preclinical trials, remark that ES cell technology might be promising for clinical practice. ES cells, which can form three germ layers in vitro, are potential candidates to study development at the cellular and molecular level. Understanding the cell fate decision and differentiation processes during development might enable generating functional progenitor cells for tissue restoration...
February 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29460272/hyperglycemia-in-children-hospitalized-with-acute-asthma
#2
Khalid F Mobaireek, Abdulrahman Alshehri, Abdulaziz Alsadoun, Abdullah Alasmari, Abdullah Alashhab, Meshal Alrumaih, Mohammad Alothman, Abdullah A Alangari
Hyperglycemia is frequently observed in adults with acute asthma. We aimed to assess the frequency of hyperglycemia and its relation to outcomes in children admitted with acute asthma. In this retrospective study, we reviewed medical records of non-diabetic 166 children (66 girls) with the mean age of 5.4 ± 2.6 years (range of 2-12 years), who were hospitalized with acute asthma between January 2012 through December 2014. Data pertaining to demographics, vital signs, oxygen saturation, serum blood glucose level, electrolytes, blood gases, and admission were collected...
February 20, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29460271/serpina1-gene-variants-in-granulomatosis-with-polyangiitis
#3
Malgorzata Hadzik-Blaszczyk, Aneta Zdral, Tadeusz M Zielonka, Ada Rozy, Renata Krupa, Andrzej Falkowski, Kazimierz A Wardyn, Joanna Chorostowska-Wynimko, Katarzyna Zycinska
Alpha-1 antitrypsin (A1AT) deficiency is one of the most common genetic disorders in Caucasian population. There is a link between granulomatosis with polyangiitis (GPA) and most frequent variants of SERPINA1 gene encoding severe alpha-1 antitripsin deficiency. However, the potential effect of Pi*Z, Pi*S as well as other SERPINA1 variants on clinical course of vasculitis are not well understood. The aim of the study was to analyze the potential effect of A1AT protein phenotype representing the SERPINA1 gene variants on the clinical course of GPA...
February 20, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453670/incidence-and-drug-resistance-of-zoonotic-mycobacterium-bovis-infection-in-peshawar-pakistan
#4
Irfan Khattak, Muhammad Hassan Mushtaq, Sultan Ayaz, Sajid Ali, Anwar Sheed, Javed Muhammad, Muhammad Luqman Sohail, Haq Amanullah, Irshad Ahmad, Sadeeq Ur Rahman
Prevalence of zoonotic Mycobacterium bovis (bTB) disease in human population is underreported from the North of Pakistan. Here, we report on the proportion of human bTB disease among the overall TB patients, drug resistance pattern of bTB isolates, and knowledge, attitude, and practices (KAP)-based analysis of bTB disease. For this purpose, sputum samples from a total of 300 clinically diagnosed TB patients and 100 randomly selected school children suspected of pulmonary TB were processed by culture as well as polymerase chain reaction (PCR) for isolation, identification, and confirmation of Mycobacterium tuberculosis (mTB) and bTB species...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453669/physical-training-and-cardiac-rehabilitation-in-heart-failure-patients
#5
Cesare de Gregorio
Regardless of advances in medical and interventional treatment of cardiovascular disease (CVD), a limited number of patients attend a cardiac rehabilitation (CR) programme on a regular basis. Due to modern therapies more individuals will be surviving an acute cardiovascular event, but the expected burden of chronic heart failure will be increasing worldwide.However, both in high- and low-income countries, secondary prevention after an acute myocardial infarction or stroke has been implemented in less than a half of eligible patients...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29445996/baker-s-asthma-is-the-ratio-of-rye-flour-specific-ige-to-total-ige-more-suitable-to-predict-the-outcome-of-challenge-test-than-specific-ige-alone
#6
V van Kampen, I Sander, R Merget, T Brüning, M Raulf
Usually the diagnosis of baker's asthma is based on specific inhalation challenge with flours. To a certain extent the concentration of specific IgE to flour predicts the outcome of challenge test in bakers. The aim of this study was to evaluate whether the ratio of specific IgE (sIgE) to total IgE (tIgE) improves challenge test prediction in comparison to sIgE alone. Ninety-five bakers with work-related respiratory symptoms were challenged with rye flour. Total IgE, sIgE, and the sIgE/tIgE ratio were determined...
February 15, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29445995/long-term-exposure-to-ambient-air-pollution-in-childhood-adolescence-and-lung-function-in-adulthood
#7
A Dubrowski, K Kliś, M Żurawiecka, K Dereń, M Barszcz, D Nowakowski, I Wronka
The aim of the study was to evaluate the effect of air pollution in the dwelling place during childhood-adolescence on respiratory function in early adulthood. The study was conducted in 220 female and 160 male university undergraduates in the cities of Cracow and Wroclaw in Poland and consisted of spirometry to assess lung function. The subjects' exposure to pollution during childhood-adolescence was assessed from the data acquired by the Polish Chief Inspectorate for Environmental Protection. We found differences in all spirometry variables depending on benz[a]piren exposure, in FVC% and FEV 1 /%FVC depending on PM 2...
February 15, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29445994/estimation-of-posturographic-trajectory-using-k-nearest-neighbors-classifier-in-patients-with-rheumatoid-arthritis-and-osteoarthritis
#8
Beata Sokołowska, Teresa Sadura-Sieklucka, Leszek Czerwosz, Marta Hallay-Suszek, Bogdan Lesyng, Krystyna Księżopolska-Orłowska
Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic diseases and account for a significant percentage of disability. Posturography is a method that assesses postural stability and quantitatively evaluates postural sways. The objective of this study was to estimate posturographic trajectories applying pattern recognition algorithms. To this end, k-nearest neighbors (k-NN) classifier was used to differentiate between healthy subjects and patients with OA and RA. The following parameters of trajectories were computed: radius of sways, developed area, total length, and two directional components of sways: length of left-right and forward-backward motions...
February 15, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29435957/oscillations-of-subarachnoid-space-width-as-a-potential-marker-of-cerebrospinal-fluid-pulsatility
#9
Marcin Gruszecki, Magdalena K Nuckowska, Arkadiusz Szarmach, Marek Radkowski, Dominika Szalewska, Monika Waskow, Edyta Szurowska, Andrzej F Frydrychowski, Urszula Demkow, Pawel J Winklewski
In the cerebrospinal fluid (CSF) circulation, two components can be distinguished: bulk flow (circulation) and pulsatile flow (back and forth motion). CSF pulsatile flow is generated by both cardiac and respiratory cycles. Recent years have seen increased interest in cardiac and respiratory-driven CSF pulsatility as an important component of cerebral homeostasis. CSF pulsatility is affected by cerebral arterial inflow and jugular outflow and potentially linked to white matter abnormalities in various diseases, such as multiple sclerosis or hypertension...
February 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29435956/robot-assisted-body-weight-supported-treadmill-training-in-gait-impairment-in-multiple-sclerosis-patients-a-pilot-study
#10
Marek Łyp, Iwona Stanisławska, Bożena Witek, Ewelina Olszewska-Żaczek, Małgorzata Czarny-Działak, Ryszard Kaczor
This study deals with the use of a robot-assisted body-weight-supported treadmill training in multiple sclerosis (MS) patients with gait dysfunction. Twenty MS patients (10 men and 10 women) of the mean of 46.3 ± 8.5 years were assigned to a six-week-long training period with the use of robot-assisted treadmill training of increasing intensity of the Lokomat type. The outcome measure consisted of the difference in motion-dependent torque of lower extremity joint muscles after training compared with baseline before training...
February 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29435955/effects-of-manual-somatic-stimulation-on-the-autonomic-nervous-system-and-posture
#11
Giovanni Barassi, Rosa Grazia Bellomo, Camillo Di Giulio, Giuseppe Giannuzzo, Giuseppe Irace, Claudia Barbato, Raoul Saggini
Low back pain frequently involves a multifactorial etiology and requires medical attention. The aim of the study was to assess the associations among pain, posture, and autonomic nervous system function in patients with low back pain, using neuromuscular manual therapy versus a generic peripheral manual stimulation (back massage therapy). Twenty young patients with low back pain were enrolled into the study. The patients were randomly divided into two groups: treated with neuromuscular manual therapy performed after a specific structural evaluation and treated with back massage therapy...
February 13, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29429029/very-high-frequency-oscillations-of-heart-rate-variability-in-healthy-humans-and-in-patients-with-cardiovascular-autonomic-neuropathy
#12
Mario Estévez-Báez, Calixto Machado, Julio Montes-Brown, Javier Jas-García, Gerry Leisman, Adam Schiavi, Andrés Machado-García, Claudia Carricarte-Naranjo, Eli Carmeli
Literature reports on the very high frequency (VHF) range of 0.4-0.9 Hz in heart rate variability (HRV) are scanty. The VHF presence in cardiac transplant patients and other conditions associated with reduced vagal influence on the heart encouraged us to explore this spectral band in healthy subjects and in patients diagnosed with cardiac autonomic neuropathy (CAN), and to assess the potential clinical value of some VHF indices. The study included 80 healthy controls and 48 patients with spinocerebellar ataxia type 2 (SCA2) with CAN...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29429028/molecules-of-damage-associated-patterns-in-bronchoalveolar-lavage-fluid-and-serum-in-chronic-obstructive-pulmonary-disease
#13
Beata Brajer-Luftmann, Agata Nowicka, Mariusz Kaczmarek, Magdalena Wyrzykiewicz, Senan Yasar, Tomasz Piorunek, Marcin Grabicki, Magdalena Kostrzewska, Jan Sikora, Halina Batura-Gabryel
Chronic exposure to detrimental environmental factors may induce immunogenic cell death of structural airway cells in chronic obstructive pulmonary disease (COPD). Damage-associated molecular patterns (DAMPs) is a family of heterogeneous molecules released from injured or dead cells, which activate innate and adaptive immune responses on binding to the pattern recognition receptors on cells. This study seeks to define the content of DAMPs in the bronchoalveolar lavage fluid (BALF) and serum of COPD patients, and the possible association of these molecules with clinical disease features...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29429027/immunization-coverage-in-children-with-inflammatory-bowel-disease
#14
K Kowalska-Duplaga, M Baranowska-Nowak, M Nescioruk, M Banasiuk, K Karolewska-Bochenek, I Łazowska-Przeorek, A Radzikowski, Aleksandra Banaszkiewicz
Patients suffering from inflammatory bowel diseases (IBD) are at increased risk of infections, mainly due to immunosuppressive treatment. Moreover, infections may cause flares of IBD. Vaccination is the most effective way of preventing many infections. The aim of this study was to evaluate the vaccination status of Polish children with IBD. Individual immunization cards of children with IBD and healthy controls were reviewed. Demographic data such as age, sex, and IBD history, including therapy type, were collected...
February 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29423675/the-robust-potential-of-mesenchymal-stem-cell-loaded-constructs-for-hard-tissue-regeneration-after-cancer-removal
#15
Samaneh Hosseini, Mohammad Amin Shamekhi, Shahrbanoo Jahangir, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad
Malignant bone tumors, although quite rare, are one of the causes of death in children and adolescents. Surgery as a common and primary treatment for removal of virtually bone cancer cause large bone defects. Thus, restoration of hard tissues like bone and cartilage after surgical tumor resection needs efficient therapeutic approaches. Tissue engineering (TE) is a powerful approach which has provided hope for restoration, maintenance, or improvement of damaged tissues. This strategy generally supplies a three-dimensional scaffold as an active substrate to support cell recruitment, infiltration, and proliferation for neo-tissues...
February 9, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29423674/intravenous-infusion-of-human-adipose-tissue-derived-mesenchymal-stem-cells-to-treat-type-1-diabetic-mellitus-in-mice-an-evaluation-of-grafted-cell-doses
#16
Loan Thi-Tung Dang, Anh Nguyen-Tu Bui, Cong Le-Thanh Nguyen, Nhat Chau Truong, Anh Thi-Van Bui, Ngoc Phan Kim, Kiet Dinh Truong, Phuc Van Pham
Mesenchymal stem cell (MSC) transplantation is a novel treatment for diabetes mellitus, especially type 1 diabetes. Many recent publications have demonstrated the efficacy of MSC transplantation on reducing blood glucose and increasing insulin production in both preclinical and clinical trials. However, the investigation of grafted cell doses has been lacking. Therefore, this study aimed to evaluate the different doses of MSCs on treatment of type 1 diabetes in mouse models. MSCs were isolated and expanded from human adipose tissue...
February 9, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29411336/central-sleep-apnea-with-cheyne-stokes-breathing-in-heart-failure-from-research-to-clinical-practice-and-beyond
#17
K Terziyski, A Draganova
Characterized by periodic crescendo-decrescendo pattern of breathing alternating with central apneas, Central sleep apnea (CSA) with Cheyne-Stokes Breathing represents a highly prevalent, yet underdiagnosed comorbidity in chronic heart failure (CHF). A diverse body of evidence demonstrates increased morbidity and mortality in the presence of CSB. CSB has been described in both CHF patients with preserved and reduced ejection fraction, regardless of drug treatment. Risk factors for CSB are older age, male gender, high BMI, atrial fibrillation and hypocapnia...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29411335/evolving-role-of-natriuretic-peptides-from-diagnostic-tool-to-therapeutic-modality
#18
Ines Pagel-Langenickel
Natriuretic peptides (NP) are widely recognized as key regulators of blood pressure, water and salt homeostasis. In addition, they play a critical role in physiological cardiac growth and mediate a variety of biological effects including antiproliferative and anti-inflammatory effects in other organs and tissues. The cardiac release of NPs ANP and BNP represents an important compensatory mechanism during acute and chronic cardiac overload and during the pathogenesis of heart failure where their actions counteract the sustained activation of renin-angiotensin-aldosterone and other neurohormonal systems...
February 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29392579/tuberculosis-of-the-urogenital-tract-in-adults-in-a-tertiary-referral-center
#19
Jacek Jagodziński, Tadeusz M Zielonka, Krystyna Peplińska, Katarzyna Życińska
The genitourinary system is the main location of extrapulmonary tuberculosis. In Poland, it occupies the third place after tuberculosis of the pleura and lymph nodes. The aim of this study was to evaluate the prevalence and characteristics of tuberculosis in the urogenital tract in adult patients in a tertiary referral center in the years 2007-2015. The retrospective study included 87 patients, 42 women and 45 men. The average age was 62 ± 15 years. Changes in the urinary tract were diagnosed in 91% of women and 64% of men...
February 2, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29392578/circulating-biomarkers-in-heart-failure
#20
Alexander E Berezin
Biological markers have served for diagnosis, risk stratification and guided therapy of heart failure (HF). Our knowledge regarding abilities of biomarkers to relate to several pathways of HF pathogenesis and reflect clinical worsening or improvement in the disease is steadily expanding. Although there are numerous clinical guidelines, which clearly diagnosis, prevention and evidence-based treatment of HF, a strategy regarding exclusion of HF, as well as risk stratification of HF, nature evolution of disease is not well established and requires more development...
February 2, 2018: Advances in Experimental Medicine and Biology
journal
journal
21742
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"