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Advances in Experimental Medicine and Biology

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https://www.readbyqxmd.com/read/29687286/the-brca1-and-brca2-genes-in-early-onset-breast-cancer-patients
#1
Mohamed Saleem, Mohd Bazli Ghazali, Md Azlan Mohamed Abdul Wahab, Narazah Mohd Yusoff, Hakimah Mahsin, Ch'ng Ewe Seng, Imran Abdul Khalid, Mohd Nor Gohar Rahman, Badrul Hisham Yahaya
Approximately 5-10% of breast cancers are attributable to genetic susceptibility. Mutations in the BRCA1 and BRCA2 genes are the best known genetic factors to date. The goal of this study was to determine the structure and distribution of haplotypes of the BRCA1 and BRCA2 genes in early-onset breast cancer patients. We enrolled 70 patients diagnosed with early-onset breast cancer. A total of 21 SNPs (11 on BRCA1 and 10 on BRCA2) and 1 dinucleotide deletion on BRCA1 were genotyped using nested allele-specific PCR methods...
April 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29687285/anti-cancer-effect-of-xao-tam-phan-paramignya-trimera-methanol-root-extract-on-human-breast-cancer-cell-line-mcf-7-in-3d-model
#2
Lam-Huyen Nguyen-Thi, Sinh Truong Nguyen, Thao Phuong Tran, Chinh-Nhan Phan-Lu, Trung The Van, Phuc Van Pham
BACKGROUND: Cancer is one of the leading causes of death in the world. A great deal of effort has been made to discover new agents for cancer treatment. Xao tam phan (Paramignya trimera) is a traditional medicine of Vietnam used in cancer treatment for a long time, yet there is not much scientific evidence proving its anticancer potency. The study aimed to evaluate the toxicity of Paramignya trimera extract (PTE) on multicellular tumor spheres (MCTS) of MCF-7 cells using hanging drop technique...
April 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679366/blood-group-and-incidence-of-asthma-and-chronic-obstructive-pulmonary-disease
#3
Bożena Mroczek, Zygmunt Sitko, Agnieszka Sujewicz, Weronika Wolińska, Iwona Karpeta-Pawlak, Donata Kurpas
Chronic respiratory diseases are determined by genetic predisposition, and environmental and socioeconomic variables. One genetic factor underlying susceptibility to such diseases can be the ABO blood group system. The purpose of this study was to investigate the hypothesis that there would be a relationship between the blood group and risk of developing asthma and chronic obstructive pulmonary disease (COPD). We reviewed medical history files of patients with the diagnosis of COPD or asthma, including those suffering from a cancerous disease accompanied by asthma or COPD, hospitalized from January 2016 to July 2017...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679365/influence-of-gaseous-pollutants-on-copd-exacerbations-in-patients-with-cardiovascular-comorbidities
#4
Michal Zielinski, Mariusz Gasior, Dariusz Jastrzebski, Aneta Desperak, Dariusz Ziora
Exacerbations of chronic obstructive pulmonary disease (COPD) are a serious public health issue. Ambient pollution and meteorological factors are considered among precipitating factors. There are few data concerning the impact of ambient pollutants other than particulates on COPD exacerbations. Among gaseous pollutants four main groups of substances are primarily monitored: nitrogen oxides (NOx), sulphur dioxide (SO2 ), carbon monoxide (CO), and ozone (O3 ). In this study, 12,889 hospitalizations in the years 2006-2014 due to exacerbations of COPD in patients having a co-existing cardiovascular pathology were retrospectively analyzed...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679364/estimates-of-medication-expenditure-for-ischemic-heart-disease-accompanying-chronic-obstructive-pulmonary-disease
#5
Edyta Rysiak, Izabela Prokop, Ilona Zaręba, Robert M Mróz
Ischemic heart disease (IHD) is a frequent accompaniment of chronic obstructive pulmonary disease (COPD). Co-occurrence of these two diseases is associated with many risk factors, difficulties in implementing appropriate therapies, numerous complications, and high spending for treatment. All these elements significantly reduce the quality of life of patients. The aim of this study was to estimate the expenditure for medications involved with IHD pharmacotherapy in the course of COPD. This retrospective study was based on the review of medical files of 57 patients, 27 women and 30 men, diagnosed with IHD, according to the severity classification, in the course of COPD which was staged according to the GOLD criteria...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679363/proangiogenic-and-profibrotic-markers-in-pulmonary-sarcoidosis
#6
I Tuleta, L Biener, C Pizarro, G Nickenig, D Skowasch
The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. We found that VEGF levels differed significantly between the stage groups with the peak VEGF concentrations in stage III...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29644575/erratum-to-management-of-bradyarrhythmias-in-heart-failure-a-tailored-approach
#7
Daniele Masarone, Ernesto Ammendola, Anna Rago, Rita Gravino, Gemma Salerno, Marta Rubino, Tommaso Marrazzo, Antonio Molino, Paolo Calabrò, Giuseppe Pacileo, Giuseppe Limongelli
No abstract text is available yet for this article.
April 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29644574/erratum-to-percutaneous-mitral-valve-interventions-and-heart-failure
#8
Abhishek Sharma, Sunny Goel, Sahil Agrawal
No abstract text is available yet for this article.
April 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29623610/relation-between-attention-deficit-hyperactivity-disorder-and-ige-dependent-allergy-in-pediatric-patients
#9
Mateusz Miłosz, Urszula Demkow, Tomasz Wolańczyk
Food allergy is a common condition in children and adolescent, remitting with time. Few clinical studies have emphasized the link between food allergies and psychosocial conditions, suggesting a profound impact of atopic diseases on the development of attention-deficit hyperactivity disorder (ADHD) in children. The objective of this study was to compile and assess available studies on the comorbidity or causality between ADHD and atopic food allergy in children. We discuss epidemiology, interrelated mechanisms, and potential dietary interventions in the management of children with ADHD...
April 7, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29623574/does-patient-specific-instrumentation-improve-femoral-and-tibial-component-alignment-in-total-knee-arthroplasty-a-prospective-randomized-study
#10
Artur Stolarczyk, Lukasz Nagraba, Tomasz Mitek, Magda Stolarczyk, Jarosław Michał Deszczyński, Maciej Jakucinski
Alignment of the prosthesis is one of the most significant factors that affect the long-term clinical outcome following total knee arthroplasty (TKA). There is conflicting evidence whether patient-specific instrumentation (PSI) for TKA improves the component position compared to standard instrumentation. This study aimed to compare the rotational alignment of the femoral and tibial components in TKA patients when performed with either conventional or PSI. Sixty patients with primary knee osteoarthritis were randomly divided into two groups treated surgically with TKA: one with conventional instrumentation and the other with the Visionaire PSI system (Smith and Nephew, Memphis, TN)...
April 6, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29623573/bioactive-oleic-derivatives-of-dopamine-a-review-of-the-therapeutic-potential
#11
Mieczyslaw Pokorski, Dominika Zajac
Lipid derivatives of dopamine are a novel class of compounds raising a research interest due to the potential of their being a vehicle for dopamine delivery to the brain. The aim of the present paper is to review the main features of the two most prominent bioactive members of this family, namely, N-oleoyl-dopamine (OLDA) and 3'-O-methyl-N-oleoyl-dopamine (OMe-OLDA), with emphasis on the possible therapeutic properties.
April 6, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29616481/preoperative-rehabilitation-in-lung-cancer-patients-yoga-approach
#12
Giovanni Barassi, Rosa Grazia Bellomo, Antonella Di Iulio, Achille Lococo, Annamaria Porreca, Piera Attilia Di Felice, Raoul Saggini
Lung cancer is one of the leading causes of cancer death worldwide. Surgical removal remains the best option for most tumors of this type. Reduction of cigarette consumption in patients with lung cancer candidates for the surgery could limit the impact of tobacco on postsurgical outcomes. Breathing exercises appear to help combat cigarette cravings. Yoga exercise benefits have been studied in lung cancer survivors, rather than in the preoperative setting. In this study, we have recruited 32 active smokers affected by lung cancer and being candidates for pulmonary surgery...
April 4, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29603079/effects-of-breast-and-prostate-cancer-metastases-on-lumbar-spine-biomechanics-rapid-in-silico-evaluation
#13
J Lorkowski, O Grzegorowska, M S Kozień, I Kotela
Metastases to distant organs are a frequent occurrence in cancer diseases. The skeletal system, especially the spine, is one such organ. The objective of this study was to apply a numerical modeling, using a finite element method (FEM), for the evaluation of deformation and stress in lumbar spine in bone metastases to the spine. We investigated 20 patients (10 women and 10 men) aged 38-81 years. In women, osteolytic lesions in lumbar spine accompanied breast cancer, in men it was prostate cancer. Geometry of FEM models were built based on CT scans of metastatic lumbar spine...
March 31, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29594741/psychological-determinants-of-attitude-toward-euthanasia-a-comparative-study-of-female-nurses-and-female-nonmedical-professionals
#14
Alicja Głębocka
Moral, legal, and psychological aspects of the legality of euthanasia are subject to debates and studies of various communities. Diagnosing attitudes toward euthanasia should involve not only determining the proportion between its supporters and opponents but also the describing of mechanisms behind the development of particular views. The aim of the present study was to determine the psychological determinants of attitudes, such as fear of death-dying, self-esteem, and mood. The methods consisted of using the following questionnaires: the Głębocka-Gawor Attitudes Toward Euthanasia Inventory, the Ochsmann Fear of Death and Dying Inventory, the Dymkowski Self-Description Scale, the Adamczyk-Glebocka Negative Mood Inventory, and a measure of unconscious fear of death...
March 30, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29594754/improvement-in-gait-pattern-after-knee-arthroplasty-followed-by-proprioceptive-neuromuscular-facilitation-physiotherapy
#15
Joanna Jaczewska-Bogacka, Artur Stolarczyk
The aim of the study was to assess the influence of a physiotherapy program based on proprioceptive neuromuscular facilitation (PNF) on kinematic gait pattern after total knee arthroplasty. This comparative study included two groups of patients qualified for total surgical knee joint replacement due to osteoarthritis: a study group and a control group, either consisting of 28 patients of a matched age range of 55-90 years. Following surgery, 4 days after standard postoperative rehabilitation, the study patients were subjected to a 3-week-long therapist-assisted rehabilitation based on PNF principles (10 sessions of 75 min each), whereas control patients were discharged with instructions on how to exercise in the home setting...
March 29, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29594753/next-generation-sequencing-of-hepatitis-c-virus-hcv-mixed-genotype-infections-in-anti-hcv-negative-blood-donors
#16
Maciej Janiak, Kamila Caraballo Cortés, Karol Perlejewski, Dorota Kubicka-Russel, Piotr Grabarczyk, Urszula Demkow, Marek Radkowski
The infection with more than one hepatitis C virus (HCV) genotype especially in subjects with a high risk of multiple HCV exposures has been demonstrated. The role of HCV mixed-genotype infection in viral persistence and treatment effect is not fully understood. The prevalence of such infection varies greatly depending on the technique used for genotype determination and studied population. Next-generation sequencing (NGS) which is suitable for extensive analysis of complex viral populations is a method of choice for studying mixed infections...
March 29, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29572679/copeptin-blood-content-as-a-diagnostic-marker-of-chronic-kidney-disease
#17
Stanisław Niemczyk, Longin Niemczyk, Wawrzyniec Żmudzki, Marek Saracyn, Katarzyna Czarzasta, Katarzyna Szamotulska, Agnieszka Cudnoch-Jędrzejewska
Plasma content of copeptin increases with the advancement of chronic kidney disease (CKD). The purpose of this study was to evaluate copeptin content as a potential marker of CKD, as a single pathology or with coexisting heart failure. Seventy-six patients were divided into the following groups: Group 1 (control), without CKD and heart failure; Group 2, CKD stage 3a; Group 3, CKD stage 3b; Group 4, CKD stage 4; Group 5, CKD stage 5; and Group 6, CKD stage 3b and heart failure. For all patients, plasma concentrations of copeptin, creatinine, urea, cystatin C, sodium, C-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and blood pH were assessed...
March 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29572678/perspective-on-broad-acting-clinical-physiological-effects-of-photobiomodulation
#18
Steven Shanks, Gerry Leisman
Research into photobiomodulation reveals beneficial effects of light therapy for a rapidly expanding list of medical conditions and illnesses. Although it has become more widely accepted by the mainstream medicine, the effects and mechanisms of action appear to be poorly understood. The therapeutic benefits of photobiomodulation using low-energy red lasers extend far beyond superficial applications, with a well-described physics allowing an understanding of how red lasers of certain optimum intensities may cross the cranium...
March 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29569114/the-phox-homology-px-domain
#19
Mintu Chandra, Brett M Collins
The phox-homology (PX) domain is a phosphoinositide-binding domain conserved in all eukaryotes and present in 49 human proteins. Proteins containing PX domains, many of which are also known as sorting nexins (SNXs), have a large variety of functions in membrane trafficking, cell signaling, and lipid metabolism in association with membranes of the secretory and endocytic system. In this review we discuss the structural basis for both canonical lipid interactions with the endosome-enriched lipid phosphatidylinositol-3-phosphate (PtdIns3P) as well as non-canonical lipids that promote membrane association...
March 23, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29564775/airway-obstruction-in-sleep-apnea-patients
#20
Magdalena Kostrzewska, Tomasz Trafas, Barbara Bromińska, Halina Batura-Gabryel, Sławomir Michalak, Beata Brajer-Luftmann, Agata Nowicka, Marcin Grabicki, Przemysław Guzik, Tomasz Piorunek
Obstructive sleep apnea (OSA) is a condition of breathing pathology occurring during sleep, characterized by repeated episodes of upper airway obstruction. The aim of the study was to determine the occurrence of airway obstruction in smoking males with OSA in whom lung function tests had not been performed before. One hundred and four current smokers selected from 1241 patients were enrolled for the research. The subjects included in the study smoked minimum 20 cigarettes a day for at least 10 years. The diagnosis of OSA was confirmed by polysomnography (PSG) in the Sleep Laboratory and subjects were assigned to one of three groups, depending on the severity of OSA...
March 22, 2018: Advances in Experimental Medicine and Biology
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