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Advances in Experimental Medicine and Biology

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https://www.readbyqxmd.com/read/28405893/airway-and-blood-inflammatory-markers-in-waste-collectors
#1
M Raulf, V van Kampen, H D Neumann, V Liebers, A Deckert, T Brüning, J Bünger, F Hoffmeyer
Waste collectors are exposed to a heterogeneous mixture of bioaerosols able to induce health effects. The study aim was to evaluate inflammatory processes in blood and in the respiratory tract via analysis of atopy and club cell secretory protein 16 (CC16) in serum, exhaled nitric oxide (FeNO), and cellular and soluble mediators in nasal lavage fluid (NALF) and induced sputum (IS). Sixty nine current waste collectors (48% smokers) and 28 former waste collectors (25% smokers) were included in the cross-sectional study...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405892/pro-inflammatory-cytokines-in-psychiatric-disorders-in-children-and-adolescents-a-review
#2
Paulina Miłkowska, Katarzyna Popko, Urszula Demkow, Tomasz Wolańczyk
Cytokines are a large group of small proteins which play a significant role in cell signaling and regulate a variety of processes in organisms, including proliferation and differentiation of many cells, mediation in defense reactions and regulation of hematopoiesis. Cytokines can be divided into those with pro- and those with anti-inflammatory properties. In the group of pro-inflammatory cytokines the most important are: IL-1 beta, IL-6, TNF-alpha, and IFN-gamma. Pro-inflammatory cytokines might be involved in the pathophysiology of many psychiatric conditions in adults, but their role in children and adolescents is less clear...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405891/renalase-in-children-with-glomerular-kidney-diseases
#3
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Mizerska-Wasiak, Elżbieta Kuźma-Mroczkowska, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Urszula Demkow, Małgorzata Pańczyk-Tomaszewska
Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. This study seeks to determine the role of renalase in children with glomerular kidney diseases. We evaluated the serum renalase, arterial stiffness, intima-media thickness, blood pressure, and clinical and biochemical parameters in 78 children (11.9 ± 4.6 years of age) with glomerulopathies such as idiopathic nephrotic syndrome (40 cases), IgA nephropathy (12 cases), Henoch-Schönlein nephropathy (12 cases), and other glomerulopathies (14 cases)...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405890/seroprevalence-of-bartonella-species-in-patients-with-ocular-inflammation
#4
Joanna Brydak-Godowska, Dorota Kopacz, Piotr K Borkowski, Beata Fiecek, Agata Hevelke, Daniel Rabczenko, Stanisława Tylewska-Wierzbanowska, Dariusz Kęcik, Tomasz Chmielewski
Bartonella species, vector-borne etiologic agents of many systemic or self-limited infections, are responsible for a widening spectrum of diseases in humans, including inflammatory conditions of the eye. The aim of this study was to determine whether there is any relationship between uveitis and the evidence of Bartonella spp. infection in the serum, ocular fluid, and cataract mass in patients with intraocular inflammation. Polymerase chain reaction (PCR)-based tests and DNA sequencing were performed on surgery-extracted specimens of intraocular fluid and lens mass of 33 patients...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28389992/detection-of-biofilms-in-biopsies-from-chronic-rhinosinusitis-patients-in-vitro-biofilm-forming-ability-and-antimicrobial-susceptibility-testing-in-biofilm-mode-of-growth-of-isolated-bacteria
#5
Mariagrazia Di Luca, Elena Navari, Semih Esin, Melissa Menichini, Simona Barnini, Andrej Trampuz, Augusto Casani, Giovanna Batoni
Chronic rhinosinusitis (CRS) is the most common illness among chronic disorders that remains poorly understood from a pathogenic standpoint and has a significant impact on patient quality of life, as well as healthcare costs. Despite being widespread, little is known about the etiology of the CRS. Recent evidence, showing the presence of biofilms within the paranasal sinuses, suggests a role for biofilm in the pathogenesis. To elucidate the role of biofilm in the pathogenesis of CRS, we assessed the presence of biofilm at the infection site and the ability of the aerobic flora isolated from CRS patients to form biofilm in vitro...
April 8, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382609/metabolic-syndrome-as-a-factor-affecting-systemic-inflammation-in-patients-with-chronic-obstructive-pulmonary-disease
#6
R Rubinsztajn, T Przybyłowski, M Maskey-Warzęchowska, M Paplińska-Goryca, P Nejman-Gryz, K Karwat, R Chazan
Chronic obstructive pulmonary disease (COPD) is a systemic disease which may be associated with other comorbidities. The aim of the study was to estimate the incidence of metabolic syndrome (MS) in COPD patients and to assess its impact on systemic inflammation and lung function. MS was diagnosed in accordance with the recommendations of the Polish Forum for the Prevention of Cardiovascular Diseases. The study group consisted of 267 patients with stable COPD in all stages of severity. All patients underwent spirometry with bronchial reversibility testing and 6 min walk test (6MWT)...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382608/malnutrition-and-quality-of-life-in-patients-with-non-small-cell-lung-cancer
#7
Jacek Polański, Beata Jankowska-Polańska, Izabella Uchmanowicz, Mariusz Chabowski, Dariusz Janczak, Grzegorz Mazur, Joanna Rosińczuk
Progressive weight loss, common reduces performance and quality of life in patients with advanced lung cancer. However, there is a paucity of studies that focus on nutritional status and quality of life of non-small cell lung cancer (NSCLC) patients. The present study seeks to determine the nutritional status, and its relation to quality of life, of NSCLC patients. One hundred and eighty NSCLC patients (mean age 62.8 ± 9.6 years) were evaluated during therapy at the Lower Silesian Center of Lung Diseases in Wroclaw, Poland...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382607/frailty-and-primary-sarcopenia-a-review
#8
Eli Carmeli
Increasing longevity, coupled with rising frailty and sarcopenia of aging, significantly affects function and quality of life of older adults. This review discusses the definition, assessment, and management of frailty and sarcopenia, and examines the relationship between them. Medline, Scopus and Psychoinfo databases were searched using the keywords frailty, sarcopenia, aging, and functional disability. The findings are that frailty and sarcopenia are often assessed clinically with such methods such as DeXA, CT scan, MRI, bioelectrical impedance, or anthropometry...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382606/exercise-strategies-to-counteract-brain-aging-effects
#9
Dominika Szalewska, Marek Radkowski, Urszula Demkow, Pawel J Winklewski
Stimulating structural and functional adaptation that improves cognitive performance in specific tasks is the major objective of therapeutic exercise training. In this review we briefly summarize central physiological mechanisms activated by exercise. We further discuss the influence of different kinds of exercise on cognitive improvement. In particular, the effects on cognitive function of aerobic endurance, resistance and respiratory exercise, and combinations thereof are presented. The accumulating evidence reinforces the position that regular aerobic, and possibly also resistance training, offers a powerful tool to cope with biologic aging of central nervous system functions...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28364363/preface-emerging-viruses-from-early-detection-to-intervention
#10
Giuseppe Ippolito, Giovanni Rezza
In the last decades, several viruses emerged, as the consequence of cross-species passage from animal reservoirs to human being. Emerging infections always represent a significant challenge for public health system as knowledge about specific pathogens are generally little while and no/few effective interventions are available. In this volume we explored special aspects of emerging infectious diseases including: the application of the theory of focality of diseases to infective syndrome; the human-animal inter-face focusing on influenza; the role of bats as main reservoir of emerging and novel human pathogens; Middle East Respiratory Syndrome Coronavirus (MERS-CoV) epidemiology and clinical presentation; immediate impact on human health of the last Zika virus outbreak occurred in Pacific Ocean and the Americas; the role and potential application of animal models for the study of emerging infections, to improve disease knowledge and for developing therapeutic drugs during ongoing outbreak...
April 1, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28357775/alpha-wavelet-power-as-a-biomarker-of-antidepressant-treatment-response-in-bipolar-depression
#11
Wojciech Jernajczyk, Paweł Gosek, Miroslaw Latka, Klaudia Kozlowska, Łukasz Święcicki, Bruce J West
There is mounting evidence of a link between the properties of electroencephalograms (EEGs) of depressive patients and the outcome of pharmacotherapy. The goal of this study was to develop an EEG biomarker of antidepressant treatment response which would require only a single EEG measurement. We recorded resting 21-channel EEG in 17 in-patients suffering from bipolar depression in eyes-closed and eyes-open conditions. The EEG measurement was performed at the end of a short washout period which followed previous unsuccessful pharmacotherapy...
March 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28321829/prosthetic-joint-infections-and-cost-analysis
#12
F S Haddad, A Ngu, J J Negus
Prosthetic joint infection is a devastating complication of arthroplasty surgery that can lead to debilitating morbidity for the patient and significant expense for the healthcare system. With the continual rise of arthroplasty cases worldwide every year, the revision load for infection is becoming a greater financial burden on healthcare budgets. Prevention of infection has to be the key to reducing this burden. For treatment, it is critical for us to collect quality data that can guide future management strategies to minimise healthcare costs and morbidity / mortality for patients...
March 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315130/relationships-between-quality-of-life-in-the-psychological-domain-acceptance-of-illness-and-healthcare-services-in-patients-with-asthma
#13
Bożena Mroczek, Katarzyna Parzuchowska, Maria Jasińska-Starczewska, Tomasz Grodzki, Donata Kurpas
Asthma patients should be considered not only in terms of the medical aspects, but also the nonmedical issues associated with the psychological domain, since these are factors that can significantly improve patients' health state, quality of life, and illness acceptance, and can contribute to the reduction of healthcare utilization. The purpose of this study was to assess the acceptance of illness among asthma patients and their quality of life in the psychological domain, as well as to identify factors that influence illness acceptance and quality of life in the psychological domain...
March 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315129/influenza-vaccination-coverage-among-polish-patients-with-chronic-diseases
#14
Aneta Nitsch-Osuch, Izabella Gołębiak, Dorota Wyszkowska, Renata Rosińska, Lidia Kargul, Bożena Szuba, Piotr Tyszko, Lidia Brydak
Patients at a high-risk of severe influenza, because of their underlying health disorders, are recommended to receive a seasonal influenza vaccination. In Poland, influenza coverage rate in the general population is very low (3.4 %). However, there is little known about the coverage rate among high-risk patients. The aim of this study was to describe a general knowledge, perception, and influenza vaccination coverage rate among Polish patients with enhanced risk for influenza. We conducted a self-reported survey among 500 patients with chronic disorders: 120 pulmonary, 80 hemodialyzed, 100 thyroid cancer, and 200 cardiovascular patients...
March 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315128/rapid-influenza-diagnostic-tests-improve-suitability-of-antiviral-treatment-in-hospitalized-children
#15
Aneta Nitsch-Osuch, Ernest Kuchar, Izabela Gołębiak, Krzysztof Kanecki, Patryk Tarka, Lidia Brydak
Influenza may have a complicated course in young children. The aim of the study was to analyze the suitability of influenza treatment among children younger than 5 years hospitalized due to an influenza-like illness. We conducted a comparison of the treatment among children hospitalized in two consecutive years: 2015, when no rapid influenza diagnostic tests (RIDT) were in use, and 2016, when RIDT were implemented into a routine practice in the pediatric ward. In both seasons, nasopharyngeal swabs were collected and examined with real time qRT-PCR...
March 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315127/inherited-ventricular-arrhythmias-the-role-of-the-multi-subunit-structure-of-the-l-type-calcium-channel-complex
#16
Julie Briot, Marie-Philippe Tétreault, Benoîte Bourdin, Lucie Parent
The normal heartbeat is conditioned by transient increases in the intracellular free Ca(2+) concentration. Ca(2+) influx in cardiomyocytes is regulated by the activity of the heteromeric L-type voltage-activated CaV1.2 channel. A complex network of interactions between the different proteins forming the ion channel supports the kinetics and the activation gating of the Ca(2+) influx. Alterations in the biophysical and biochemical properties or in the biogenesis in any of these proteins can lead to serious disturbances in the cardiac rhythm...
March 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28293832/the-mechanistic-role-of-the-calcium-activated-chloride-channel-ano1-in-tumor-growth-and-signaling
#17
Anke Bill, Larry Alex Gaither
Multiple studies have described the high expression and amplification of Anoctamin 1 (ANO1) in various cancers, including, but not limited to breast cancer, head and neck cancer, gastrointestinal stromal tumors and glioblastoma. ANO1 has been demonstrated to be critical for tumor growth in breast and head and neck cancers through its regulation of EGFR signaling and pathway modulators like MAPK and protein kinase B. However, the discovery of ANO1 as a calcium activated chloride channel came as a surprise to the field and has given rise to many questions...
March 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28293831/isolated-hearing-impairment-caused-by-spata5-mutations-in-a-family-with-variable-phenotypic-expression
#18
Krzysztof Szczałuba, Krystyna Szymańska, Joanna Kosińska, Agnieszka Pollak, Victor Murcia, Anna Kędra, Piotr Stawiński, Małgorzata Rydzanicz, Urszula Demkow, Rafał Płoski
Biallelic mutations in the SPATA5 gene, encoding ATPase family protein, are an important cause of newly recognized epileptic encephalopathy classified as epilepsy, hearing loss, and mental retardation syndrome (EHLMRS, OMIM: 616577). Herein we describe a family in which two SPATA5 mutations with established pathogenicity (p.Thr330del and c.1714+1G>A) were found in the proband and her younger sister. The proband had a similar clinical picture to the previous descriptions of EHLMRS. In the sister, the only manifestation was an isolated sensorineural hearing loss...
March 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28293830/hypertension-from-basic-research-to-clinical-practice
#19
Md Shahidul Islam
Hypertension increases the risks of end-organ injury, maternal/fetal vulnerability, and total mortality. Throughout the world, it kills about 7.5 million people every year. During 1975-2015, the number of adults with hypertension increased from 594 million to more than 1.1 billion, mostly due to the increase in the low-income and middle-income countries (NCD Risk Factor Collaboration 2016, Lancet 15 Nov, 2016).
March 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28290102/public-perception-of-the-risks-associated-with-infectious-diseases-in-poland-ebola-and-influenza-and-their-impact-on-the-attitude-to-vaccination
#20
Ernest Kuchar, Kamila Ludwikowska, Dominik Marciniak, Leszek Szenborn, Aneta Nitsch-Osuch
While the Ebola outbreak in 2014 was strongly highlighted in mainstream media and perceived as a threat to public health in Poland, influenza was regarded as a triviality and the vaccination coverage was low. In the present study, by analyzing feedback from an on-line questionnaire (from November 2014 to January 2015) we assessed the knowledge concerning Ebola and influenza together with attitudes to immunization of 544 respondents (45% medical staff). The findings were that 92.6% of respondents declared readiness to vaccination before traveling to endemic regions if a vaccine against Ebola would have existed, but adverse reactions, high costs, and low effectiveness would adversely affect that decision...
March 14, 2017: Advances in Experimental Medicine and Biology
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