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Advances in Experimental Medicine and Biology

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https://www.readbyqxmd.com/read/28512681/evaluation-of-immune-indices-and-serum-vitamin-d-content-in-children-with-atopic-dermatitis
#1
Agnieszka Lipińska-Opałka, Agata Wawrzyniak, Sławomir Lewicki, Robert Zdanowski, Bolesław Kalicki
The influence of vitamin D on allergic diseases, including atopic dermatitis, is linked to the presence of vitamin D nuclear receptors in immune cells. The present study seeks to determine the possible relationship between serum vitamin D content and immune indices in children with atopic dermatitis. The study was conducted in 19 children with atopic dermatitis. The control consisted of 17 age-matched healthy children. A single significant finding was a distinctly lower number of serum regulatory T cells in atopic dermatitis compared with controls (p < 0...
May 17, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28456932/synergistic-activity-for-natural-and-synthetic-inhibitors-of-angiogenesis-induced-by-murine-sarcoma-l-1-and-human-kidney-cancer-cells
#2
Barbara J Bałan, Andrzej K Siwicki, Krzysztof Pastewka, Urszula Demkow, Piotr Skopiński, Ewa Skopińska-Różewska, Sławomir Lewicki, Robert Zdanowski
Tumor angiogenesis is an important link in the process of tumor growth and metastasis. A number of substances with an anti-angiogenic activity has been described, but their efficiency remains low. Many researchers believe that a better therapeutic effect could be achieved using a cocktail of several anti-angiogenic agents, having different points of action. A lot of synthetic and natural products of plant and animal origin have anti-tumor and anti-angiogenic properties. The aim of the present study was to evaluate the effect of some combinations of angiogenesis inhibitors on the growth and neovascularization of murine sarcoma L-1 , and on angiogenesis induced in the mouse skin by grafting of human renal cancer...
April 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28456931/thyroid-autoimmunity-in-girls-with-turner-syndrome
#3
Ewelina Witkowska-Sędek, Ada Borowiec, Anna Kucharska, Karolina Chacewicz, Małgorzata Rumińska, Urszula Demkow, Beata Pyrżak
Turner syndrome is associated with increased incidence of autoimmune diseases, especially those of the thyroid gland. The aim of this study was to assess the prevalence of thyroid autoimmunity among pediatric patients with Turner syndrome. The study was retrospective and included 41 girls with Turner syndrome aged 6-18 years. Free thyroxine (FT4), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (TPO-Ab) antibodies, anti-thyroglobulin (TG-Ab) antibodies, and karyotype were investigated. The correlation between karyotype and incidence of thyroid autoimmunity was also examined...
April 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28456930/mortality-due-to-nosocomial-infection-with-klebsiella-pneumoniae-esbl
#4
Katarzyna Starzyk-Łuszcz, Tadeusz M Zielonka, Joanna Jakubik, Katarzyna Życińska
Klebsiella pneumoniae is one of the most important hospital pathogens, particularly concerning the multidrug-resistant strain ESBL(+). The aim of this study was to evaluate nosocomial infections with K. pneumoniae ESBL(+) in the context of infection location, risk factors, and prognosis. This hospital study was conducted retrospectively and covered a 3 months' period. The infection with K. pneumoniae ESBL(+) was diagnosed in 36 patients (19 women and 17 men) of the mean age of 74.2 ± 14.8 years. The number of infected patients amounted to 2...
April 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28456929/carotid-intima-media-thickness-and-metabolic-syndrome-components-in-obese-children-and-adolescents
#5
Małgorzata Rumińska, Ewelina Witkowska-Sędek, Anna Majcher, Michał Brzewski, Aneta Czerwonogrodzka-Senczyna, Urszula Demkow, Beata Pyrżak
Obesity in children and adolescents contributes to increased prevalence of metabolic and hemodynamic complications, which may impair endothelial function and structure. A high resolution B-mode ultrasound measurement of intima-media thickness (IMT) is a useful tool to assess early, preclinical stage of atherosclerosis. The objective of this study was to evaluate the carotid artery IMT in obese children and its association with insulin resistance and other traditional metabolic syndrome components. The study entailed 80 obese children, aged 5...
April 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28456928/pro-inflammatory-cytokines-in-psychiatric-disorders-in-children-and-adolescents-a-review
#6
Paulina Miłkowska, Katarzyna Popko, Urszula Demkow, Tomasz Wolańczyk
Cytokines are a large group of small proteins which play a significant role in cell signaling and regulate a variety of processes in organisms, including proliferation and differentiation of many cells, mediation in defense reactions and regulation of hematopoiesis. Cytokines can be divided into those with pro- and those with anti-inflammatory properties. In the group of pro-inflammatory cytokines the most important are: IL-1 beta, IL-6, TNF-alpha, and IFN-gamma. Pro-inflammatory cytokines might be involved in the pathophysiology of many psychiatric conditions in adults, but their role in children and adolescents is less clear...
April 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28455832/structure-and-function-of-the-two-component-cytotoxins-of-staphylococcus-aureus-learnings-for-designing-novel-therapeutics
#7
Adriana Badarau, Nikolina Trstenjak, Eszter Nagy
Staphylococcus aureus can produce up to five different bi-component cytotoxins: two gamma-hemolysins HlgAB and HlgCB, and leukocidins SF-PV (Panton Valentine leukocidin), ED (LukED) and GH (LukGH, also called LukAB). Their major function in S. aureus pathogenesis is to evade innate immunity by attacking phagocytic cells and to support bacterial growth by lysing red blood cells. The five cytotoxins display different levels of amino acid sequence conservation (30-82%), but all form a remarkably similar beta-barrel type pore structure (greatly resembling the mono-component toxin alpha-hemolysin) that inserts into the target cell membrane leading to necrotic cell death...
April 29, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28452003/the-public-health-impact-of-the-so-called-fluad-effect-on-the-2014-2015-influenza-vaccination-campaign-in-italy-ethical-implications-for-health-care-workers-and-health-communication-practitioners
#8
Roberto Rosselli, Mariano Martini, Nicola Luigi Bragazzi, Abdulla Watad
Seasonal influenza, causing complications, hospitalizations and deaths, generates a serious socio-economic burden, especially among elderly and high-risk subjects, as well as among adult individuals. Despite the availability and active free-of charge offer of influenza vaccines, vaccine coverage rates remain low and far from the target established by the Ministry of Health. Notwithstanding their effectiveness, vaccines are victims of prejudices and false myths, that contribute to the increasing phenomenon of vaccine hesitancy and loss of confidence...
April 28, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28447329/immune-response-against-salmonella-enteritidis-is-unsettled-by-hiv-infection
#9
Maira Costa Cacemiro, Milena Sobral Espíndola, Leonardo Judson Galvão-Lima, Luana Silva Soares, Caroline Fontanari, Marco Aurélio Prata, Fábio Campioni, Juliana Pfrimer Falcão, Valdes Roberto Bollela, Fabiani Gai Frantz
The human immunodeficiency virus (HIV) is responsible for more than 2 million new infections per year and opportunistic infections such as Salmonella spp. Gastroenteritis is an important cause of mortality and morbidity in developing countries. Monocytes and macrophages play a critical role in the innate immune response against bacterial infections. However during HIV infection the virus can infect these cells and although they are more resistant to the cytopathic effects, they represent an important viral reservoir in these patients...
April 27, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405893/airway-and-blood-inflammatory-markers-in-waste-collectors
#10
M Raulf, V van Kampen, H D Neumann, V Liebers, A Deckert, T Brüning, J Bünger, F Hoffmeyer
Waste collectors are exposed to a heterogeneous mixture of bioaerosols able to induce health effects. The study aim was to evaluate inflammatory processes in blood and in the respiratory tract via analysis of atopy and club cell secretory protein 16 (CC16) in serum, exhaled nitric oxide (FeNO), and cellular and soluble mediators in nasal lavage fluid (NALF) and induced sputum (IS). Sixty nine current waste collectors (48% smokers) and 28 former waste collectors (25% smokers) were included in the cross-sectional study...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405892/pro-inflammatory-cytokines-in-psychiatric-disorders-in-children-and-adolescents-a-review
#11
Paulina Miłkowska, Katarzyna Popko, Urszula Demkow, Tomasz Wolańczyk
Cytokines are a large group of small proteins which play a significant role in cell signaling and regulate a variety of processes in organisms, including proliferation and differentiation of many cells, mediation in defense reactions and regulation of hematopoiesis. Cytokines can be divided into those with pro- and those with anti-inflammatory properties. In the group of pro-inflammatory cytokines the most important are: IL-1 beta, IL-6, TNF-alpha, and IFN-gamma. Pro-inflammatory cytokines might be involved in the pathophysiology of many psychiatric conditions in adults, but their role in children and adolescents is less clear...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405891/renalase-in-children-with-glomerular-kidney-diseases
#12
Piotr Skrzypczyk, Joanna Przychodzień, Małgorzata Mizerska-Wasiak, Elżbieta Kuźma-Mroczkowska, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Urszula Demkow, Małgorzata Pańczyk-Tomaszewska
Studies suggest that renalase, a renal catecholamine-inactivating enzyme, plays a major role in the pathogenesis of kidney and cardiovascular diseases in adults. This study seeks to determine the role of renalase in children with glomerular kidney diseases. We evaluated the serum renalase, arterial stiffness, intima-media thickness, blood pressure, and clinical and biochemical parameters in 78 children (11.9 ± 4.6 years of age) with glomerulopathies such as idiopathic nephrotic syndrome (40 cases), IgA nephropathy (12 cases), Henoch-Schönlein nephropathy (12 cases), and other glomerulopathies (14 cases)...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28405890/seroprevalence-of-bartonella-species-in-patients-with-ocular-inflammation
#13
Joanna Brydak-Godowska, Dorota Kopacz, Piotr K Borkowski, Beata Fiecek, Agata Hevelke, Daniel Rabczenko, Stanisława Tylewska-Wierzbanowska, Dariusz Kęcik, Tomasz Chmielewski
Bartonella species, vector-borne etiologic agents of many systemic or self-limited infections, are responsible for a widening spectrum of diseases in humans, including inflammatory conditions of the eye. The aim of this study was to determine whether there is any relationship between uveitis and the evidence of Bartonella spp. infection in the serum, ocular fluid, and cataract mass in patients with intraocular inflammation. Polymerase chain reaction (PCR)-based tests and DNA sequencing were performed on surgery-extracted specimens of intraocular fluid and lens mass of 33 patients...
April 13, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28389992/detection-of-biofilms-in-biopsies-from-chronic-rhinosinusitis-patients-in-vitro-biofilm-forming-ability-and-antimicrobial-susceptibility-testing-in-biofilm-mode-of-growth-of-isolated-bacteria
#14
Mariagrazia Di Luca, Elena Navari, Semih Esin, Melissa Menichini, Simona Barnini, Andrej Trampuz, Augusto Casani, Giovanna Batoni
Chronic rhinosinusitis (CRS) is the most common illness among chronic disorders that remains poorly understood from a pathogenic standpoint and has a significant impact on patient quality of life, as well as healthcare costs. Despite being widespread, little is known about the etiology of the CRS. Recent evidence, showing the presence of biofilms within the paranasal sinuses, suggests a role for biofilm in the pathogenesis. To elucidate the role of biofilm in the pathogenesis of CRS, we assessed the presence of biofilm at the infection site and the ability of the aerobic flora isolated from CRS patients to form biofilm in vitro...
April 8, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382609/metabolic-syndrome-as-a-factor-affecting-systemic-inflammation-in-patients-with-chronic-obstructive-pulmonary-disease
#15
R Rubinsztajn, T Przybyłowski, M Maskey-Warzęchowska, M Paplińska-Goryca, P Nejman-Gryz, K Karwat, R Chazan
Chronic obstructive pulmonary disease (COPD) is a systemic disease which may be associated with other comorbidities. The aim of the study was to estimate the incidence of metabolic syndrome (MS) in COPD patients and to assess its impact on systemic inflammation and lung function. MS was diagnosed in accordance with the recommendations of the Polish Forum for the Prevention of Cardiovascular Diseases. The study group consisted of 267 patients with stable COPD in all stages of severity. All patients underwent spirometry with bronchial reversibility testing and 6 min walk test (6MWT)...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382608/malnutrition-and-quality-of-life-in-patients-with-non-small-cell-lung-cancer
#16
Jacek Polański, Beata Jankowska-Polańska, Izabella Uchmanowicz, Mariusz Chabowski, Dariusz Janczak, Grzegorz Mazur, Joanna Rosińczuk
Progressive weight loss, common reduces performance and quality of life in patients with advanced lung cancer. However, there is a paucity of studies that focus on nutritional status and quality of life of non-small cell lung cancer (NSCLC) patients. The present study seeks to determine the nutritional status, and its relation to quality of life, of NSCLC patients. One hundred and eighty NSCLC patients (mean age 62.8 ± 9.6 years) were evaluated during therapy at the Lower Silesian Center of Lung Diseases in Wroclaw, Poland...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382607/frailty-and-primary-sarcopenia-a-review
#17
Eli Carmeli
Increasing longevity, coupled with rising frailty and sarcopenia of aging, significantly affects function and quality of life of older adults. This review discusses the definition, assessment, and management of frailty and sarcopenia, and examines the relationship between them. Medline, Scopus and Psychoinfo databases were searched using the keywords frailty, sarcopenia, aging, and functional disability. The findings are that frailty and sarcopenia are often assessed clinically with such methods such as DeXA, CT scan, MRI, bioelectrical impedance, or anthropometry...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28382606/exercise-strategies-to-counteract-brain-aging-effects
#18
Dominika Szalewska, Marek Radkowski, Urszula Demkow, Pawel J Winklewski
Stimulating structural and functional adaptation that improves cognitive performance in specific tasks is the major objective of therapeutic exercise training. In this review we briefly summarize central physiological mechanisms activated by exercise. We further discuss the influence of different kinds of exercise on cognitive improvement. In particular, the effects on cognitive function of aerobic endurance, resistance and respiratory exercise, and combinations thereof are presented. The accumulating evidence reinforces the position that regular aerobic, and possibly also resistance training, offers a powerful tool to cope with biologic aging of central nervous system functions...
April 6, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28357775/alpha-wavelet-power-as-a-biomarker-of-antidepressant-treatment-response-in-bipolar-depression
#19
Wojciech Jernajczyk, Paweł Gosek, Miroslaw Latka, Klaudia Kozlowska, Łukasz Święcicki, Bruce J West
There is mounting evidence of a link between the properties of electroencephalograms (EEGs) of depressive patients and the outcome of pharmacotherapy. The goal of this study was to develop an EEG biomarker of antidepressant treatment response which would require only a single EEG measurement. We recorded resting 21-channel EEG in 17 in-patients suffering from bipolar depression in eyes-closed and eyes-open conditions. The EEG measurement was performed at the end of a short washout period which followed previous unsuccessful pharmacotherapy...
March 30, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28321829/prosthetic-joint-infections-and-cost-analysis
#20
F S Haddad, A Ngu, J J Negus
Prosthetic joint infection is a devastating complication of arthroplasty surgery that can lead to debilitating morbidity for the patient and significant expense for the healthcare system. With the continual rise of arthroplasty cases worldwide every year, the revision load for infection is becoming a greater financial burden on healthcare budgets. Prevention of infection has to be the key to reducing this burden. For treatment, it is critical for us to collect quality data that can guide future management strategies to minimise healthcare costs and morbidity / mortality for patients...
March 21, 2017: Advances in Experimental Medicine and Biology
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