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Archives of Oral Biology

Wenying Song, Yanli Wang, Qing Chu, Congcong Qi, Yuehua Gao, Yan Gao, Lili Xiang, Xu Zhenzhen, Yuguang Gao
OBJECTIVES: In order to understand the specific in vivo function of transforming growth factor-beta1 (TGF-β1), we successfully established aTGF-β1 deficient mouse model using a conditional knockout method. In the present study, we aimed to further understand the potential role of TGF-β1 in enamel formation. DESIGN: Transgenic mice withoutTGF-β1 in epithelial cells were generated. Scanning electron microscopy and micro-computed tomography analysis were used to detect the dental appearance, enamel microstructure and tooth density...
September 12, 2018: Archives of Oral Biology
Samira Helena João-Souza, Alana Cristina Machado, Raquel Marianna Lopes, Denise Maria Zezell, Tais Scaramucci, Ana Cecilia Corrêa Aranha
OBJECTIVE: To evaluate dentin permeability and tubule occlusion of in-office desensitizing treatments, and to analyze their resistance to erosive/abrasive challenges. DESIGN: Ninety-one 1mm-thick dentin discs were immersed in EDTA solution for 5 min. After analyzing the maximum dentin permeability, the specimens were randomly allocated into 7 experimental groups (n = 10): Control (no treatment); Er,Cr:YSGG laser; Nd:YAG laser; Gluma Desensitizer; Duraphat; Pro-Argin toothpaste; Calcium Sodium Phosphosilicate (CSP) paste...
September 12, 2018: Archives of Oral Biology
Chi-Yang Tsai, Hsin-Ping Lee, Hung-Ming Chang, Fang-Chun Wu
BACKGROUND AND OBJECTIVE: In clinical practice, malocclusion is often encountered during the period of growth and development of individuals. In addition to nutritional imbalance, some studies have found that mastication affects learning and memory ability. Tooth loss and masticatory hypofunction have been suggested as risk factors of Alzheimer disease. However, relatively little research has been done in developing animals. The present study evaluated the relationship between masticatory hypofunction and neuropathological changes of the hippocampus in developing rats...
September 12, 2018: Archives of Oral Biology
Shikha Jain, Yasmin Ahmad, Kalpana Bhargava
OBJECTIVE: Identification of molecular signatures having key roles in hypobaric hypoxia by analysing the salivary proteome. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being non-invasive. METHODOLOGY: We employed qualitative proteomics approach to develop discriminatory biomarker signatures from human saliva exposed to hypobaric hypoxia. Salivary proteins were analyzed and compared between age-matched healthy subjects exposed to high altitude (∼13700 ft) for seven days (HAD7) with control subjects at sea level (Normoxia) by using 2-Dimensional gel electrophoresis/Mass Spectrometry approach...
September 7, 2018: Archives of Oral Biology
Yongchun Gu
No abstract text is available yet for this article.
September 6, 2018: Archives of Oral Biology
Martine Morzel, Hélène Brignot, Franck Ménétrier, Géraldine Lucchi, Vincent Paillé, Patricia Parnet, Sophie Nicklaus, Marie-Chantal Canivenc-Lavier
OBJECTIVE: Maternal diet has consequences on many organs of the offspring, but salivary glands have received little attention despite the importance of the saliva secretory function in oral health and control of food intake. The objective of this work was therefore to document in rats the impact of maternal high-fat/high-sugar diet (Western Diet) on submandibular glands of the progeny. DESIGN: Sprague-Dawley rat dams were fed either a Western diet or control diet during gestation and lactation and their pups were sacrificed 25 days after birth...
September 5, 2018: Archives of Oral Biology
Anastasios Koutsoumparis, Angelina Vassili, Athina Bakopoulou, Argyro Ziouta, Asterios S Tsiftsoglou
OBJECTIVE: Mesenchymal stem cells (MSCs) have attracted worldwide attention for their capacity to repair damaged tissue, immunosuppression, ability to differentiate into several cell types and their secretome. Earlier studies have demonstrated their angiogenic potential in vitro and in vivo. However, little is known regarding pro-angiogenic inducers of stable endothelial transdifferentiation of MSCs. Here, we employed human MSCs from the Apical Papilla (SCAP) and investigated whether recombinant human erythropoietin-alpha (rhEPOa) could act as such inducer...
September 3, 2018: Archives of Oral Biology
Luke Stanisce, Etty Sims, Cheryl Hou, Yekaterina Koshkareva, John P Gaughan, Igor Kuzin, Andrea Bottaro
OBJECTIVE: The goal of this study was to gain a better understanding of the potential functional specialization of palatine and pharyngeal tonsils, by comparing their cellular composition in paired specimens from a large cohort of adenotonsillectomy patients. DESIGN: Resident B cell, T cell, dendritic cell, and stromal cell subsets were characterized using multicolor flow cytometry in palatine and pharyngeal tonsil specimens from 27 patients, age 2-34 years. RESULTS: Paired comparisons showed highly significant intra-individual differences in resident cell subsets of palatine and pharyngeal tonsils...
September 1, 2018: Archives of Oral Biology
Hongguang Zhu, Shouyi Lu, Meirong Wei, Xiaoshan Cai, Guoyou Wang
OBJECTIVE: This study aimed to identify the differentially expressed genes (DEGs) in gingiva epithelial cells responding to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis infections using bioinformatics method. STUDY DESIGN: GSE9723 dataset was downloaded from Gene Expression Omnibus, and DEGs between the infected cells and controls were identified using unpaired t-test. Overlapping DEGs in responding to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis infections were extracted...
August 30, 2018: Archives of Oral Biology
Qiuju Wang, Xiaoqin Zhang, Xiaoyu Song, Li Zhang
OBJECTIVE: To evaluate T-cadherin gene expression in patients with oral squamous cell carcinoma(OSCC) and explore its effect on the proliferation of OSCC. Additionally, the present study aimed to determine whether the anti-proliferative effect of T-cadherin was associated with the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway. DESIGN: A reverse transcription-quantitative polymerase chain reaction was performed to detect T-cadherin mRNA expression...
August 30, 2018: Archives of Oral Biology
Maki Sato, Tadasu Sato, Takehiro Yajima, Kenichiro Shimazaki, Hiroyuki Ichikawa
OBJECTIVE: Distribution of the transient receptor potential cation channel subfamily V members 1 (TRPV1) and 2 (TRPV2), and P2X purinoceptor 3 (P2 × 3) was investigated in rat trigeminal ganglion neurons innervating the periosteum, masseter muscle and facial skin. DESIGN: Double immunofluorescence method for TRPV1 and TRPV2 ion channels or ATP receptor P2 × 3 with calcitonin gene-related peptide (CGRP) was performed on trigeminal ganglion neurons retrogradely labeled from the mandibular periosteum, masseter muscle, or facial skin in 15 male Wistar rats...
August 30, 2018: Archives of Oral Biology
João Botelho, Vanessa Machado, Paulo Mascarenhas, João Rua, Ricardo Alves, Maria Alzira Cavacas, Ana Delgado, José João Mendes
OBJECTIVE: This meta-analysis aims to systematically assess whether periodontitis has a meaningful effect on salivary cortisol, reflecting changes on free blood cortisol levels. DESIGN: The Cochrane Handbook and the PRISMA statement were used as reporting guidelines. The MEDLINE-PubMed, Google Scholar, EMBASE, and CENTRAL databases were searched until September 2017 to identify eligible studies, screened by seven independent authors and verified by an eighth. Studies comparing salivary cortisol level of periodontitis cases to controls were included...
August 30, 2018: Archives of Oral Biology
Shigeru Takahashi, Rui Takebuchi, Hiroto Taniwaki, Takanori Domon
OBJECTIVE: In this study, we aimed to clarify how parotid glands, made atrophic by a liquid diet, recover after diet change. DESIGN: Seven-week-old male Wistar rats were fed a pellet (control group) or a liquid diet (experimental group) for the first 14 days. Thereafter, all animals were fed a pellet diet for up to 14 days (days 0-14). The parotid glands were removed, weighed and examined histologically and ultrastructurally. Immunohistochemistry was performed for BrdU, a marker of proliferating cells, and Casp-3, a marker of apoptotic cells...
August 25, 2018: Archives of Oral Biology
Amela Tulek, Muhammad Saeed, Aida Mulic, Kjersti Refsholt Stenhagen, Tor Paaske Utheim, Hilde Kanli Galtung, Cuong Khuu, Minou Nirvani, Marthe Smedmoen Kristiansen, Amer Sehic
OBJECTIVE: Consumption of acidic food and drinks is considered as important risk factor for development of dental erosion. There are several in vitro and in situ studies focusing on the risk indicators and preventive treatment, however, the need for a standardized animal model has been emphasised for many years. The aim was to establish an animal model of extrinsic dental erosion, which may serve as a standard for future studies to improve our understanding of the erosion. DESIGN: Two acidic drinks, sports drink and cola drink, were given to young mice for six weeks...
August 24, 2018: Archives of Oral Biology
Joo-Hee Lee, Hyungkeun Kim, Jae Hoon Shim, Junhee Park, Sun Kyoung Lee, Kwang-Kyun Park, Won-Yoon Chung
OBJECTIVE: Remodeling of alveolar bone is controlled by osteoclast-mediated bone resorption and osteoblast-induced bone formation. LPS of Porphyromonas gingivalis, a major causative agent of periodontitis, produces proinflammatory cytokines in host immune cells, which thereby triggers osteoclastogenesis and leads to alveolar bone resorption. We investigated the anti-periodontitis potential of Platycarya strobilacea leaf extract (PLE), which is used as a traditional medicine in Asian countries...
August 24, 2018: Archives of Oral Biology
Bianca Núbia Souza-Silva, Walbert de Andrade Vieira, Ítalo de Macedo Bernardino, Marília Jesus Batista, Marcos Alan Vieira Bittencourt, Luiz Renato Paranhos
OBJECTIVE: This study aimed to investigate the prevalence and the factors associated with non-syndromic tooth agenesis, besides identifying its pattern of occurrence. STUDY DESIGN: Pre-orthodontic exams of 3400 subjects, aged 8-30 years, were selected from a radiographic center in Brazil. Panoramic and periapical radiographs were analyzed to verify the presence of tooth agenesis and other six dental anomalies. Descriptive statistics were calculated using the Tooth Agenesis Code tool and, to evaluate significant associations, a negative binomial regression model was constructed...
August 24, 2018: Archives of Oral Biology
Lizet Jarquín-Yñezá, Jorge Alejandro Alegría-Torres, Claudia G Castillo, José de Jesús Mejía-Saavedra
OBJECTIVE: To determine the allelic and genotypic frequencies of rs 412777 polymorphism in the Collagen type I alpha 2 chain (COL1A2) gene and the association with the severity of dental fluorosis in children between 6 and 12 years old in the State of San Luis Potosi, Mexico. DESIGN: A cross-sectional study was designed; participants were 230 children from two rural communities of San Luis Potosí. Fluoride in drinking water and urine samples was quantified using a potentiometric method with a selective ion electrode...
August 23, 2018: Archives of Oral Biology
Masahiro Takahashi, Kazuyoshi Hosomichi, Tetsutaro Yamaguchi, Ryo Nagahama, Hiroshi Yoshida, Mary L Marazita, Seth M Weinberg, Koutaro Maki, Atsushi Tajima
OBJECTIVE: The aim of the present study is to explore genetic factors determining difference of cleft side using whole-genome sequencing and evaluation of craniofacial morphology using cephalometric analysis between Japanese monozygotic (MZ) twins with mirror-image cleft lip and palate (CLP). DESIGN: We selected a Japanese MZ twin pair (MZ-A and MZ-B) affected with unilateral CLP who are discordant for cleft side (left/right) and conducted whole-genome sequencing to identify genetic factors determining cleft side...
August 19, 2018: Archives of Oral Biology
M Ramírez-Salomón, E Vega-Lizama, P Quintana-Owen, A Cucina, V Tiesler
OBJECTIVE: The ancient Maya used to practice dental inlays as part of the cultural traditions. Most of those inlays remain in place after more than one thousand years. The purpose of this paper is to investigate the incidence of pulp pathosis associated with ancient Maya dental inlays to assess the impact that such common practice had on the population's oral health. DESIGN: We scored 193 anterior inlaid teeth from 107 pre-Hispanic Maya dentitions studied at three archaeological storage facilities (Universidad Autonoma de Yucatan, Harvard University, Atlas of Guatemala Project)...
August 19, 2018: Archives of Oral Biology
Bo Zhao, Ronghua Li
BACKGROUND: To evaluate the association between periodontitis and interleukin-6 (IL6) -174 G/C polymorphism by data synthesis and subgroup analysis. METHODS: Eighteen case-control studies from 16 articles with 1616 cases and 1511 controls were included in this meta-analysis by searching the public databases including PubMed, Embase and Web of Science databases by Jun 2018. Data syntheses were performed using Stata 9.0. RESULTS: There were inverse associations of IL6 -174 G/C polymorphism with both general periodontitis and overall periodontitis...
August 18, 2018: Archives of Oral Biology
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