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Archives of Oral Biology

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https://www.readbyqxmd.com/read/29778623/hypothesis-driven-versus-hypothesis-free-approaches-to-the-identification-of-genes-for-cleft-lip-and-palate
#1
Alexandre R Vieira
Much progress has been made in understanding the genetic contributions to isolated forms of cleft lip and palate, however this effort is yet to be translated to enhanced genetic counseling or prevention strategies. Interest in the topic was renewed with the ability to perform genome-wide genotyping and after a few of those relatively larger scale studies, many are considering more targeted efforts and to focus on specific genes and/or loci. Here we discuss this crossroad and suggest targeted approaches and rethought clinical descriptions are a better way to move the field forward...
May 16, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29778624/conditioning-of-human-salivary-flow-using-a-visual-cue-for-sour-candy
#2
Jonathan C Kershaw, Cordelia A Running
OBJECTIVE: Although the "mouthwatering" to sight, smell, or thought of food is commonly accepted in food and nutrition research, the concept of mouthwatering and human salivary flow conditioning is not well accepted in salivary research. The objective of this study was to revisit whether human salivary flow could be classically conditioned to a previously neutral stimulus. DESIGN: Sour candy or a non-food control in opaque containers were presented to healthy participants (n = 8)...
May 14, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29763781/inhibition-of-vegf-gene-expression-in-osteoblast-cells-by-different-nsaids
#3
Francisco Javier Manzano-Moreno, Victor Javier Costela-Ruiz, Lucía Melguizo-Rodríguez, Rebeca Illescas-Montes, Olga García-Martínez, Concepción Ruiz, Javier Ramos-Torrecillas
OBJECTIVE: To determine the effect of different nonsteroidal anti-inflammatory drugs (NSAIDs) on vascular endothelial growth factor (VEGF) gene expression in two osteoblast cell populations. DESIGN: Osteoblasts obtained by primary culture (HOp) and human osteosarcoma cell line MG63 (MG-63), which were treated with 10 μM doses of acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen or piroxicam. At 24 h of treatment, their gene expression of VEGF was evaluated by real-time polymerase chain reaction (RT-PCR) and compared with the expression in untreated cells (control group)...
May 9, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29775860/a-cone-beam-computed-tomography-study-of-the-mesial-cervical-concavity-of-maxillary-first-premolars
#4
Linfeng Fan, Keyong Yuan, Chenguang Niu, Rui Ma, Zhengwei Huang
OBJECTIVE: To investigate the mesial cervical concavity of maxillary first premolars and its relationship with root and canal configuration using cone-beam computed tomography (CBCT). DESIGN: Images of maxillary first premolars (n = 1056) were collected from patients (n = 601) who had undergonein vivo CBCT scanning. The root and canal number and morphology were evaluated. The following measurements of the mesial cervical concavity of the maxillary first premolars were evaluated in section images: dentine thickness (in concavity at the cemento-enamel junction), concavity angle, depression depth (distance from mesial dentinal surface at concavity to mesial proximity), concavity position (distance from mesial dentinal wall at invagination to the top of the mesial marginal ridge)...
May 7, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29751148/salivary-immunoglobulin-levels-in-juvenile-autoimmune-hepatitis
#5
Juliana Ximenes Damasceno, Maria Izabel Florindo Guedes, Christiane Araujo Chaves Leite, André Jalles Monteiro, Manasses Claudino Fonteles, Maria Esther Zurita Jimenez, Vilma de Lima, Thyciana Rodrigues Ribeiro, Cristiane Sá Roriz Fonteles
AIMS: The aim of the present study was to investigate the presence of immunoglobulins (Ig) in whole saliva from patients affected by autoimmune hepatitis (AIH). DESIGN: Twelve individuals with AIH and 12 healthy individuals without (CON) autoimmune hepatitis, aged 8-18 years, participated in this study. Non-stimulated whole saliva was collected and centrifuged. Supernatants were separated and lyophilized. Salivary pH was measured and immunoglobulins were analyzed through ELISA technique...
May 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29753928/dynamic-changes-of-th1-th2-th17-cytokines-and-human-beta-defensin-2-in-hiv-infected-patients-with-oral-candidiasis-during-the-first-year-of-highly-active-anti-retroviral-therapy
#6
Xiangzhi Yong, Zhenmin Liu, Lanlan Jiang, Renchuan Tao, Wei Liu, Linlin Zhang, Yuanyuan Peng, Xuefang Lin, Yuxiao Huang
OBJECTIVE: To investigate the change of Th1/Th2/Th17 cytokines and human beta defensin 2 (HBD-2) in HIV-infected patients with oral candidiasis (OC) and gather information about OC-specific immunity. DESIGN: During the 1st year of highly active anti-retroviral therapy (HAART), 25 HIV-infected patients were followed up at the baseline, 3rd, 6th, 12th month. At each visit, oral manifestations were examined; oral rinses were collected and cultured for Candida; peripheral venous blood was taken to determine CD4 + T cell counts and HIV RNA viral load (VL); both unstimulated whole saliva and peripheral venous blood were taken to determine cytokine (IL-4, IL-17(A/F), IFN-γ) and HBD-2 levels...
May 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29775861/screening-methylation-of-dna-repair-genes-in-the-oral-mucosa-of-chronic-smokers
#7
Celina Faig Lima Carta, Mônica Ghislaine Oliveira Alves, Patrícia Pimentel de Barros, Márcia Sampaio Campos, Jaqueline Scholz, Antonio Olavo Cardoso Jorge, Fábio Daumas Nunes, Janete Dias Almeida
OBJECTIVE: The aim of this study was to evaluate the epigenetic changes in the process of oral carcinogenesis by screening the methylation of repair genes in chronic smokers. DESIGN: Two groups were formed: Group 1: 16 smokers with consumption of 20 cigarettes/day for at least 10 years; and Group 2: 10 non-smoking. Exfoliative cytology of the tongue was performed, and the extracted DNA was treated by enzymes. The PCR Array System performed methylation screening to evaluate 22 DNA repair genes, and the results were validated by RT-qPCR for each gene with methylation levels ≥10%...
May 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29763780/polymorphonuclear-neutrophil-integrity-and-functionality-are-preserved-when-exposed-to-saliva
#8
Patrick Rijkschroeff, Sabrina T G Gunput, Antoon J M Ligtenberg, Enno C I Veerman, Bruno G Loos, Elena A Nicu
OBJECTIVE: Polymorphonuclear neutrophils (PMNs) are the most abundant innate immune cells and are also important effectors in the maintenance of oral health. However, little is known about the effects of saliva on the PMN. We therefore aimed to investigate the effect of saliva on the PMNs' morphology and functioning. DESIGN: Effect of saliva on the membrane integrity of PMNs isolated from blood was evaluated with FACS using Annexin V (apoptosis marker) and propidum iodide (membrane integrity marker)...
May 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29729478/sources-of-free-radicals-and-oxidative-stress-in-the-oral-cavity
#9
REVIEW
Piotr Żukowski, Mateusz Maciejczyk, Danuta Waszkiel
OBJECTIVE: An oral cavity is a place especially susceptible to oxidative damage. It is subjected to many environmental pro-oxidative factors or factors that have the ability to generate reactive oxygen species (ROS). The aim of this article is to present the main sources of ROS and oxidative stress in the oral environment. DESIGN: A literature search was performed using the PubMed and Google Scholar databases. RESULTS: One of the most important ROS sources in the oral cavity is periodontal inflammation...
May 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29751147/assessment-of-genotyping-tools-applied-in-genetic-susceptibility-studies-of-periodontal-disease-a-systematic-review
#10
REVIEW
Alicia de Coo, Inés Quintela, Juan Blanco, Pedro Diz, Ángel Carracedo
OBJECTIVE: A systematic review to evaluate the various genotyping tools and study strategies employed to define genetic susceptibility to periodontitis. METHODS: The review was performed in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The search for publications referring to the genetic bases of periodontal disease was performed on the MEDLINE-PubMed and Cochrane Library databases, on trials registers, and on the web pages of regulatory agencies...
April 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29751146/curcumin-enhances-anti-tumor-immune-response-in-tongue-squamous-cell-carcinoma
#11
Feng Liao, Li Liu, En Luo, Jian Hu
PURPOSE: This study evaluated the role of anti-tumor immune response of curcumin on tongue squamous cell carcinama (TSCC). EXPERIMENTAL DESIGN: Cell lines (Cal 27, FaDu) and animal model (4NQO mice model) were uesd in this study. The MTT assay was used to detecte cell proliferation. The Western blotting, immunohistochemistry and immunofluorescence were used to examine the protein expression. The flow cytometry was performed to determine the number of Treg and MDSC...
April 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29747062/biochemical-characterization-of-a-recombinant-lactobacillus-acidophilus-strain-expressing-exogenous-foma-protein
#12
Li Ma, Fei Li, Xiangyu Zhang, Xiping Feng
In previous research, to combine the immunogenicity of Fusobacterium nucleatum (F. nucleatum) and the probiotic properties of Lactobacillus acidophilus (L. acidophilus), we constructed a FomA-expressing L. acidophilus strain and assessed its immunogenicity. Our findings indicated that oral administration of the recombinant L. acidophilus strain reduced the risk of periodontal infection by Porphyromonas gingivalis (P. gingivalis) and F. nucleatum. However, because the exogenous FomA is an heterologous protein for the original bacterium, in this study, we assessed whether the biochemical characteristics of the recombinant L...
April 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29738922/behavioral-characteristics-of-capsaicin-mediated-cutaneous-myogenic-and-arthrogenic-orofacial-nociception-in-rats
#13
Eric L Rohrs, John K Neubert, Robert M Caudle, Kyle D Allen
OBJECTIVE: To assess changes in orofacial tactile sensitivity and gnawing related to capsaicin-mediated cutaneous, myogenic, and arthrogenic nociception in the rat. DESIGN: After recovery from anesthesia, orofacial tactile sensitivity and gnawing were assessed using operant testing methods following capsaicin application. Twenty female CD-Hairless rats were tested with bilateral capsaicin cream application to the cheek or with isoflurane anesthesia alone. Following several weeks of recovery, animals (n = 20) received either 10 μL unilateral masseter injections of vehicle, or phosphate buffered saline (PBS) to assess injection sensitization...
April 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29705498/whole-exome-sequencing-in-an-italian-family-with-isolated-maxillary-canine-agenesis-and-canine-eruption-anomalies
#14
Ersilia Barbato, Alice Traversa, Rosanna Guarnieri, Agnese Giovannetti, Maria Luce Genovesi, Maria Rosa Magliozzi, Stefano Paolacci, Andrea Ciolfi, Simone Pizzi, Roberto Di Giorgio, Marco Tartaglia, Antonio Pizzuti, Viviana Caputo
OBJECTIVE: The aim of this study was the clinical and molecular characterization of a family segregating a trait consisting of a phenotype specifically involving the maxillary canines, including agenesis, impaction and ectopic eruption, characterized by incomplete penetrance and variable expressivity. DESIGN: Clinical standardized assessment of 14 family members and a whole-exome sequencing (WES) of three affected subjects were performed. WES data analyses (sequence alignment, variant calling, annotation and prioritization) were carried out using an in-house implemented pipeline...
April 21, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29727722/association-between-genetic-polymorphisms-in-defb1-and-microrna202-with-caries-in-two-groups-of-brazilian-children
#15
Daniela Silva Barroso de Oliveira, Raquel Assed Bezerra Segato, Sara Oliveira, André Luiz Tannus Dutra, Adriana Stone Dos Santos, Ananda Deva Noronha Praxedes, Leandro Coelho Belém, Livia Azeredo Antunes, Andrea Lips, Paulo Nelson-Filho, Léa Assed Bezerra da Silva, Gutemberg Gomes Alves, Leonardo Santos Antunes, Erika Calvano Küchler
OBJECTIVE: This replication study aimed to evaluate an association between caries experience and polymorphisms in DEFB1 and miRNA202 in two different Brazilian groups. DESIGN: The population consisted in 312 Brazilian children. Genomic DNA for was extracted from buccal cells isolated from saliva. The genotyping analysis of the polymorphisms in DEFB1 and miRNA202 was performed by real-time polymerase chain reactions. The associations between caries experience, genotype and allele distribution was performed, with an alpha of 0...
April 20, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29694940/gene-gene-interaction-for-nonsyndromic-cleft-lip-with-or-without-cleft-palate-in-chilean-case-parent-trios
#16
José Suazo, José Luis Santos, Alicia Colombo, Rosa Pardo
OBJECTIVE: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a birth defect for which several genes susceptibility genes been proposed. Consequently, it has been suggested that many of these genes belong to common inter-related pathways during craniofacial development gene-gene interaction. We evaluated the presence of gene-gene interaction for single nucleotide polymorphisms within interferon regulatory factor 6 (IRF6), muscle segment homeobox 1 (MSX1), bone morphogenetic protein 4 (BMP4) and transforming growth factor 3 (TGFB3) genes in NSCL/P risk in Chilean case-parent trios...
April 18, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29679886/cytotoxicity-of-novel-fluoride-solutions-and-their-influence-on-mineral-loss-from-enamel-exposed-to-a-streptococcus-mutans-biofilm
#17
Thiago Isidro Vieira, João Victor Frazão Câmara, Júlia Gabiroboertz Cardoso, Adílis Kalina Alexandria, Andréa Vaz Braga Pintor, Jaqueline Correia Villaça, Lúcio Mendes Cabral, Maria Teresa Villela Romanos, Andrea Fonseca-Gonçalves, Ana Maria Gondim Valença, Lucianne Cople Maia
OBJECTIVE: This study evaluated the cytotoxicity, antimicrobial activity and in vitro influence of new fluoridated nanocomplexes on dental demineralization. DESIGN: The nanocomplexes hydroxypropyl-β-cyclodextrin with 1% titanium tetrafluoride (TiF4 ) and γ-cyclodextrin with TiF4 were compared to a positive control (TiF4 ), a blank control (without treatment) and negative controls (hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, deionized water), following 12- and 72-hour complexation periods...
April 13, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29679887/determining-chewing-efficiency-using-a-solid-test-food-and-considering-all-phases-of-mastication
#18
Ting Liu, Xinmiao Wang, Jianshe Chen, Hilbert W van der Glas
OBJECTIVES: Following chewing a solid food, the median particle size, X50 , is determined after N chewing cycles, by curve-fitting of the particle size distribution. Reduction of X50 with N is traditionally followed from N ≥ 15-20 cycles when using the artificial test food Optosil® , because of initially unreliable values of X50 . The aims of the study were (i) to enable testing at small N-values by using initial particles of appropriate size, shape and amount, and (ii) to compare measures of chewing ability, i...
April 10, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29673998/long-term-evaluation-of-the-stability-of-dentin-matrix-following-treatments-with-aqueous-solutions-of-titanium-tetrafluoride-at-different-concentrations
#19
E C Bridi, A A Leme-Kraus, B Aydin, R T Basting, A K Bedran-Russo
OBJECTIVE: The purpose of this study was to investigate the effects of aqueous solutions of different concentrations of titanium tetrafluoride (TiF4 ) on dentin matrix stability up to six months. DESIGN: Dentin specimens prepared from fifteen nonerupted molars were demineralized and randomly distributed into groups: 2.5% TiF4 , 4% TiF4, 1000 ppm NaF, and control (distilled water). The modulus of elasticity (ME) and dry masses of the dentin matrix were determined at baseline, and up to 6 months following treatment...
April 10, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29669267/differential-effects-of-natural-curcumin-and-chemically-modified-curcumin-on-inflammation-and-bone-resorption-in-model-of-experimental-periodontitis
#20
Fabiana Almeida Curylofo-Zotti, Muna S Elburki, Priscilla Aparecida Oliveira, Paulo Sérgio Cerri, Leandro Alves Santos, Hsi-Ming Lee, Francis Johnson, Lorne M Golub, Carlos Rossa, Morgana Rodrigues Guimarães-Stabili
OBJECTIVE: The purpose of this study was to compare the effects of the oral administration of natural curcumin and a chemically modified curcumin (CMC2.24) on osteoclast-mediated bone resorption, apoptosis, and inflammation in a murine model of experimental periodontal disease. DESIGN: Fifty male rats were distributed among the following treatment groups: (i) 2% carboxymethylcellulose, (ii) CMC2.24 30 mg/kg body weight, (iii) Curcumin 100 mg/kg body weight and (iv) no treatment...
April 10, 2018: Archives of Oral Biology
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