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Archives of Oral Biology

Fang Wang, Jing Zhang, Gang Zhou
OBJECTIVE: Oral lichen planus (OLP) is a common T lymphocyte-mediated autoimmune disease of unknown etiology. The mammalian target of rapamycin (mTOR) can regulate proliferation, apoptosis, and autophagy of T lymphocytes, therefore impacting the T lymphocyte-mediated immunity. The present study was aimed to investigate the possible association between Akt/mTOR/4E-BP1 (eIF4E-binding protein 1) signaling, phospholipase D (PLD) and hypoxia-inducible factor 1 alpha (Hif-1α) in peripheral T lymphocytes of OLP and the correlation of their expression with the disease severity...
November 3, 2018: Archives of Oral Biology
Dongmei Wang, Hongxu Yang, Mian Zhang, Hongyun Zhang, Lei Lu, Jing Zhang, Xianghong Wan, Meiqing Wang
OBJECTIVE: To investigate the changes in insulin-like growth factor-1 (IGF-1) expression levels in the degenerative mandibular condylar cartilage. DESIGN: Thirty-six rats were divided into the unilateral anterior crossbite and control groups. The expression levels of IGF-1; IGF-1 receptor (IGF-1R); IGF-binding protein-3 and -5 (IGFBP-3 and -5); proliferating cell nuclear antigen (PCNA); aggrecan; type-I, -II, -VI, and -X collagen; tissue inhibitor of metalloproteinases-1 and -3 (TIMP-1 and -3); metalloproteinases of matrix metalloproteinases-3 and-13 (MMP-3 and -13); a disintegrin and metalloproteinase thrombospondin-4 and -5 (ADAMTS-4 and -5); alkaline phosphatase (ALP); β-glucuronidase; and N-acetyl-β-glucosaminidase in the mandibular condylar cartilage were assessed...
November 3, 2018: Archives of Oral Biology
Tomomi T Baba, Tatsuo Terashima, Shinichiro Oida
BACKGROUND AND OBJECTIVE: Tissue non-specific alkaline phosphatase (TNSALP) contains two types-bone- and liver-type-which are produced from the same gene due to differences in splicing. These two differ in their promoter, but the amino acid sequences of the mature proteins are identical. In this study, we examined the relationship between the two types of TNSALP expression and osteoblast differentiation. DESIGN: Gene expression of the two types of TNSALP was observed by reverse transcription-polymerase chain reaction...
November 2, 2018: Archives of Oral Biology
Yan Zeng, Anna Nikitkova, Hossam Abdelsalam, Jiyao Li, Jin Xiao
OBJECTIVE: Nidus Vespae (NV) is the honeycomb of Polistes Olivaceous, P. Japonicus Saussure, and Parapolybiavaria Fabricius. Previously, we have shown the extract and chemical fractions from NV demonstrated remarkable capacities of inhibiting the acid production of oral bacteria at sub-minimum inhibitory concentration (MIC) concentrations. In searching the most potent anti-caries compounds in NV, we further separated the NV Chl/MeOH fraction and obtained two purified compounds: quercetin and kaemferol...
November 2, 2018: Archives of Oral Biology
Priscila Maria Aranda Salomão, Flávia Amadeu de Oliveira, Daiana Moreli Soares Dos Santos, João Paulo Domezi, Thiago José Dionísio, Rodrigo Cardoso de Oliveira, Ana Carolina Magalhães
OBJECTIVES: This study evaluated the level and mechanism of apoptosis in human gingival fibroblasts (HGF) and murine fibroblasts (NIH/3T3) treated with a titanium tetrafluoride (TiF4 ) varnish compared those treated with a sodium fluoride (NaF) varnish. METHODS: Cells were treated with a TiF4 , NaF (both 2.45%F) or placebo varnish for 6 h and were then examined using the TUNEL method. The activities of caspase-3, -8 and -9 were assessed. cDNA for Bax, Bad, Bcl-2 and Fas-L was amplified by quantitative PCR...
November 2, 2018: Archives of Oral Biology
Caroline Machado Kopruszinski, Renata Cristiane Dos Reis, Giles Alexander Rae, Juliana Geremias Chichorro
OBJECTIVE: To improve understanding of the pathophysiology of cancer-induced facial nociception, by evaluating the contribution of peripheral endothelin receptors in tumor-induced facial heat hyperalgesia, increased spontaneous grooming, as well as ongoing nociception in a rat model of facial cancer. DESIGN: The study was conducted using 396 rats. Facial cancer was induced by inoculating a suspension of Walker-256 cells into the rats' right vibrissal pad. Facial heat hyperalgesia and spontaneous grooming were assessed on day 6, while the conditioned place preference (CPP) test was performed on days 3-6 after tumor cells inoculation...
November 2, 2018: Archives of Oral Biology
Jia Yu, Eerika Mursu, Matleena Typpö, Sakari Laaksonen, Hanna-Marja Voipio, Paula Pesonen, Aune Raustia, Pertti Pirttiniemi
OBJECTIVES: The structure of the mandibular condylar cartilage (MCC) is regulated by dynamic and multifactorial processes. The aim of this study was to examine the effects of altered dietary loading, estrogen level, and aging on the structure of the condylar cartilage and the expressions of matrix metalloproteinase (MMP) -3 and MMP-8 of rat MCC. METHODS: In this study, Crl:CD (SD) female rats were randomly divided into 3 groups according to dietary hardness: hard diet (diet board), normal diet (pellet), and soft diet (powder)...
November 1, 2018: Archives of Oral Biology
Babak Sarrafpour, Charbel El-Bacha, Qing Li, Hans Zoellner
OBJECTIVE: Cyst expansion in bone involves bone resorption but is often accompanied by adjacent bone formation with cortication. The mechanisms for these two apparently opposite processes remain unclear. From a mechanobiological perspective, functional strain drives bone remodeling, which involves both bone apposition and resorption. In this study, we explore the role of functional strain in cyst growth. DESIGN: Using a three-dimensional finite element analysis model of a simulated cyst at the of right first mandibular molar mesial apex, we examined three loading conditions, representing biting on the right molar, left molar and incisors, respectively...
October 30, 2018: Archives of Oral Biology
Juana Rosmeri Salas Huamani, Taís de Souza Barbosa, Camila Nobre de Freitas, Karina Guedes de Sousa, Maria Beatriz Duarte Gavião, Soraya Coelho Leal, Fábio Luiz Mialhe, Paula Midori Castelo
OBJECTIVE: Although atraumatic restorative treatment (ART) is considered to be a good option for anxious patients, there is a lack of information whether ART associated to oral health educational strategy (OHES) would positively influence the level of anxiety and stress in children. This study aimed to evaluate the impact of OHES on anxiety and stress markers of schoolchildren submitted to ART. DESIGN: A sample of 78 six- to eight-year-old schoolchildren, with carious lesions in dentin, were randomly divided into groups: OHES + ART-group (n = 39) and ART-group (n = 39)...
October 29, 2018: Archives of Oral Biology
Yasuna Myose, Hisako Hikiji, Toshiyuki Tsujisawa, Kazuo Sonoki, Naomi Yada, Hiromasa Inoue
OBJECTIVE: It is important to protect the patient's oral mucosa from injury caused by inappropriate oral care. We established anin vivo model of intraepithelial injury of the oral mucosa and assessed the effects of inappropriate dental apparatus use on inflammatory response of macrophages in rats. DESIGN: Using this model, swabbing was performed to the labial mucosa of rats with the interdental brush, and the tissue samples were processed for histological evaluation...
October 29, 2018: Archives of Oral Biology
Yuan Luo, Yingdi Zhang, Guojun Miao, Yiwen Zhang, Yuehua Liu, Yuanliang Huang
OBJECTIVE: Bone marrow stem cells (BMSCs) can commit to both adipocyte and osteoblast lineages. However, the mechanism underlying how transcription factors regulate this process remains elusive. Our aims were to determine the role of runt-related transcription factor 1 (Runx1) in BMSCs lineage determination and the underlying mechanisms. STUDY DESIGN: BMSCs from mouse femur bone marrow were harvested and cultured in osteogenic medium. Runx1 was knocked down in BMSCs using lentivirus...
October 29, 2018: Archives of Oral Biology
Jose Francisco Mateo-Castillo, Otavio Pagin, Izabel Maria Marchi Carvalho, Tulio Lorenzo Olano-Dextre, Lucimara Teixeira das Neves
OBJECTIVE: The objective was to investigate dental phenotypes in individuals with non-syndromic Pierre Robin Sequence (ns-PRS) and compare the prevalence of these phenotypes with subjects with non-syndromic cleft palate (ns-CP) and a control group with subjects without any craniofacial anomalies. METHODS: A total of 760 panoramic radiographs of 330 individuals (110 with ns-PRS; 110 with ns-CP and 110 without any malformations) were digitized and evaluated regarding the diagnosis of taurodontism, tooth agenesis, root dilaceration and tooth transposition...
October 29, 2018: Archives of Oral Biology
Márcia Tonetti Ciaramicoli, Fernanda Kabadayan, Maria Martha Bernardi, Ivana Barbosa Suffredini, Cintia Helena Coury Saraceni
The pain in dentin hypersensitivity (DH) has distinct sensory and emotional origins, with variations that occur in different intensities for each individual. The aim of this study is to evaluate the effects of diazepam in the attenuation of the pain induced by DH. DESIGN: Fifty male Wistar rats were divided into five groups: control group received water ad libitum (C); stress group received water ad libitum plus stress (S); DH induced by erosion challenge with isotonic solution ad libitum (G); DH and stress (GS); and DH, stress and diazepam (GSD) groups...
October 29, 2018: Archives of Oral Biology
Yang Liu, Xiangyu Sun, Xianli Zhang, Xiaozhe Wang, Chenying Zhang, Shuguo Zheng
OBJECTIVES: Cleidocranial dysplasia (CCD), mainly caused by RUNX2 mutation, is a dominantly inherited skeletal disorder with many dental abnormalities, characterized by delayed permanent tooth eruption. In this study, we explored a novel RUNX2 mutation and the effect of RUNX2 mutation on osteogenic differentiation of dental follicle cells (DFCs). DESIGN: A CCD patient with typical clinical features was involved in this study. Conservation and secondary structural analysis of the RUNX2 mutation was first performed...
October 29, 2018: Archives of Oral Biology
Philip Bender, Andreas Egger, Martin Westermann, Nadine Taudte, Anton Sculean, Jan Potempa, Burkhard Möller, Mirko Buchholz, Sigrun Eick
OBJECTIVES: Human glutaminyl cyclases (QC and isoQC) play an important role in maintaining inflammatory conditions. Meanwhile a glutaminyl cyclase synthesized by Porphyromonas gingivalis (PgQC), a key pathogen in developing periodontitis and a potential link of periodontitis with rheumatoid arthritis (RA), was discovered. This study was aimed to determine the expression of QC, isoQC and PgQC in patients with chronic periodontitis (CP) and RA. DESIGN: Thirty volunteers were enrolled in a pilot study and divided into 3 groups (healthy, CP and RA individuals)...
October 28, 2018: Archives of Oral Biology
Luiz Felipe de Carvalho França, Felipe Rodolfo Pereira da Silva, David di Lenardo, Even Herlany Pereira Alves, Hélio Mateus Silva Nascimento, Isabela Aparecida Tito da Silva, Any Carolina Cardoso Guimarães Vasconcelos, Daniel Fernando Pereira Vasconcelos
Objective Quantitatively evaluate blood parameters of the erythrocyte lineage in patients with chronic periodontitis and healthy controls by means of a meta-analysis. Material and methods A review of literature was performed in the scientific databases for studies published before September 2016. The abstracts were evaluated and the extraction of data performed by two examiners. The parameters assessed were: hemoglobin levels, number of circulating red blood cells, hematocrit, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration in patients with chronic periodontitis and healthy controls...
October 28, 2018: Archives of Oral Biology
Yoon Nam, Yoon-Young Kim, Ji-Youn Chang, Hong-Seop Kho
OBJECTIVES: Diagnostic value of saliva depends on the reproducibility of data in repeatedly collected samples and predictable correlations between saliva and blood. We aimed to investigate the reliability, blood reflectance, and influence of blood contamination in the analysis of inflammatory and oxidative stress biomarkers in saliva samples. DESIGN: In total, 37 healthy young male participants (26.7 ± 2.2 years) were included. Unstimulated whole saliva and blood samples were collected on the first visit, and saliva samples were collected again after 2-3 days...
October 24, 2018: Archives of Oral Biology
Federica Romano, Gaia Meoni, Valeria Manavella, Giacomo Baima, Giulia Maria Mariani, Stefano Cacciatore, Leonardo Tenori, Mario Aimetti
OBJECTIVE: Metabolomic analysis of saliva proved its accuracy in discriminating patients with generalized chronic periodontitis (GCP) from healthy subjects by identifying specific molecular signatures of the disease. There is lack of investigations concerning the effect of periodontal treatment on individual metabolic fingerprints. Therefore, the aim of this study was to determine whether non-surgical periodontal therapy could change salivary metabolomic profile in GCP to one more similar to periodontal health...
October 23, 2018: Archives of Oral Biology
Tanawat Nimcharoen, Win Pa Pa Aung, Anupong Makeudom, Thanapat Sastraruji, Sakornrat Khongkhunthian, Benyapha Sirinirund, Suttichai Krisanaprakornkit, Pattanin Montreekachon
OBJECTIVE: To determine effect of non-surgical periodontal treatment on a disintegrin and metalloproteinase 8 (ADAM8) levels in gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) in comparison with those of patients with gingivitis and to find correlations between ADAM8 levels and clinical parameters. DESIGN: Twenty-two and eleven patients with CP and gingivitis, respectively, were examined for four clinical parameters, probing depth, clinical attachment level, gingival and plaque indices...
October 23, 2018: Archives of Oral Biology
Binghui Zeng, Hui Lu, Xue Xiao, Xinlin Yu, Sijie Li, Ling Zhu, Dongsheng Yu, Wei Zhao
OBJECTIVE: Tooth agenesis (TA) is featured by congenital loss of teeth, and can be divided into two subtypes, non-syndromic TA (NSTA) and syndromic TA (STA). Although 12 candidate genes of NSTA have been revealed, the genetic basis of NSTA needs to be further studied. We noticed an overlap of candidate genes between NSTA and STA, and hypothesized that some candidate genes of STA may be new candidate genes of NSTA. METHODS: Sanger sequencing, whole exome sequencing, bioinformatics analyses and immunohistochemical staining were performed to reveal the genetic basis of the patients in a family with NSTA...
October 23, 2018: Archives of Oral Biology
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