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Archives of Oral Biology

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https://www.readbyqxmd.com/read/28433620/depressive-behavior-induced-by-unpredictable-chronic-mild-stress-increases-dentin-hypersensitivity-in-rats
#1
Fabiane Martins Barbosa, Danilo Cabral, Fernanda Kabadayan, Eduardo Fernandes Bondan, Maria de Fátima Monteiro Martins, Thiago Berti Kirsten, Leoni Villano Bonamin, Nicolle Queiroz-Hazarbassanov, Maria Martha Bernardi, Cintia Helena Coury Saraceni
OBJECTIVE: The present study evaluated the nociceptive response induced by dentin hypersensitivity after dental erosion in rats that were exhibited to unpredictable chronic mild stress (UCMS)-induced depressive-like behavior. DESIGN: Adult male rats were subjected to UCMS (depression [D] group) or not (no depression [ND] group) for 30days and received either acidic solution to induce dental erosion (E) or water (W), thus forming the WND, END, WD, and ED groups. After the end of treatment, depressive-like parameters (i...
April 15, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28432900/lysophosphatidic-acid-induces-expression-of-genes-in-human-oral-keratinocytes-involved-in-wound-healing
#2
Hong Huynh Thorlakson, Stian Andre Engen, Olav Schreurs, Karl Schenck, Inger Johanne Schytte Blix
OBJECTIVE: Epithelial cells participate in wound healing by covering wounds, but also as important mediators of wound healing processes. Topical application of the phospholipid growth factor lysophosphatidic acid (LPA) accelerates dermal wound healing and we hypothesized that LPA can play a role in human oral wound healing through its effects on human oral keratinocytes (HOK). DESIGN: HOK were isolated from gingival biopsies and exposed to LPA. The LPA receptor profile, signal transduction pathways, gene expression and secretion of selected cytokines were analyzed...
April 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28414987/effects-of-different-radiation-doses-on-the-microhardness-superficial-morphology-and-mineral-components-of-human-enamel
#3
Sandra Ribeiro de Barros da Cunha, Felipe Paiva Fonseca, Pedro Augusto Minorin Mendes Ramos, Cecília Maria Kalil Haddad, Eduardo Rodrigues Fregnani, Ana Cecília Corrêa Aranha
OBJECTIVE: To evaluate the effects of three different radiotherapy doses (20, 40, and 70Gy) on the microhardness, superficial morphology, and mineral content (based on Ca and P values) of three different depths of human enamel (cervical, middle, and occlusal). DESIGN: Thirty-four third molars were cut, separated, and prepared. Microhardness samples (n=30) were embedded in acrylic resin and then polished, and depths were delimited. Microhardness tests were performed on cervical, middle, and occlusal enamel pre- and post-radiotherapy with a load of 50g for 30s...
April 10, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28419912/the-mucosal-pellicle-an-underestimated-factor-in-oral-physiology
#4
REVIEW
Christian Hannig, Matthias Hannig, Anna Kensche, Guy Carpenter
Bioadhesion and bio-adsorption of proteins, glycoproteins and other biomolecules are ubiquitous phenomena in the oral cavity. While the protective role of the adsorbed salivary biomolecules on teeth (the acquired enamel pellicle) is well established, it has yet to be defined whether comparable processes occur on the desquamating oral soft tissues. The general term for these layers is pellicle, but due to the different characteristics of the coated surfaces the enamel pellicle and mucosal pellicle are their own entities...
April 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28412610/overexpression-and-varied-clinical-significance-of-th9-versus-th17-cells-in-distinct-subtypes-of-oral-lichen-planus
#5
Hui Wang, Jingping Bai, Zhenhua Luo, Jie Fu, Hongjian Wang, Zheng Sun
OBJECTIVE: Oral lichen planus (OLP) presents with large numbers of T lymphocytes accumulating beneath the epithelium of the oral mucosa; however, its aetiology remains obscure. A potential role for an emerging novel T cell subset, Th9, in OLP has recently been suggested but remains to be clarified. The current aim was to investigate the expression and potential clinical significance of Th9 cells in distinct subtypes of OLP. MATERIALS AND METHODS: Peripheral blood samples were collected from 41 OLP patients and 18 healthy controls (HCs)...
April 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28412609/dexamethasone-promotes-regeneration-of-crushed-inferior-alveolar-nerve-by-inhibiting-nf-%C3%AE%C2%BAb-activation-in-adult-rats
#6
Wei Gao, Dongdong Tong, Qing Li, Ping Huang, Fenghe Zhang
PURPOSE: Nuclear factor kappa B (NF-κB), which is closely related to inflammation, has become a topic of interest for research. The aim of this study is to investigate the effects of dexamethasone (Dex), an inhibitor of NF-κB, on inferior alveolar nerve injury in adult rats. MATERIALS AND METHODS: The crushed inferior alveolar model is established in Wistar rats and they are randomly divided into three groups according to treatment: pyrrolidine dithiocarbamate (PDTC), dexamethasone (Dex), and saline (physiological saline)...
April 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28433619/lack-of-pathogenic-mutations-in-sos1-gene-in-phenytoin-induced-gingival-overgrowth-patients
#7
Katia Margiotti, Giulia Pascolini, Federica Consoli, Valentina Guida, Carlo Di Bonaventura, Anna Teresa Giallonardo, Antonio Pizzuti, Alessandro De Luca
OBJECTIVE: Gingival overgrowth is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressants, and calcium channel blockers. One of the main drugs associated with gingival overgrowth is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. It has been shown that mutation of human SOS1 gene is responsible for a rare hereditary gingival fibromatosis type 1, a benign gingival overgrowth. The aim of the present study is to evaluate the possible contribution of SOS1 mutation to gingival overgrowth-related phenotype...
April 5, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28399470/evaluation-of-the-effect-of-tacrolimus-on-periodontitis-induced-in-rats
#8
Luiz Alexandre Moura Penteado, Gilmara Medeiros Lucena, Marcílio Otávio Brandão Peixoto, Thiago Correia Barbosa, Ana Carolina de Souza Leitão Arruda, Renata Cimões
OBJECTIVE: This study was to investigate the effect of tacrolimus (FK506) on periodontitis induced in rats. DESIGN: Periodontal disease was induced in 30 Wistar rats which were then randomly divided into two groups: treatment with a daily injection of 0.9% saline (1mL/day) and treatment with a daily injection of FK506. After periods of 10, 15 and 30days the animals were killed and separate radiographs of the right and left hemimandibles were obtained. One calibrated examiner measured the periodontal bone support (PBS) in the images, after the following treatments: S, saline without ligature; SL, saline with ligature; T, FK506 without ligature; TL, FK506 with ligature...
April 2, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28399469/development-of-medial-pterygoid-muscle-fibers-in-rabbits-fed-with-a-liquid-diet
#9
Kozue Kuroki, Takumi Morita, Hiroki Takasu, Keisuke Saito, Takuya Fujiwara, Katsunari Hiraba, Shigemi Goto
OBJECTIVE: This study aimed to investigate the influence of decreased functional load on the medial pterygoid muscle during mastication in rabbits fed with a liquid-diet. MATERIALS AND METHODS: Medial pterygoid muscles from 54 rabbits (solid- and liquid-diet groups, n=48; unweaned group, n=6) were histochemically examined at 4, 9, 12, 18, and 33 weeks after birth. Six fiber types (I, IC, IIC, IIA, IIAB, and IIB) were distinguished via mATPase staining. RESULTS: Significant increases in the diameters of all fiber types were seen up to 33 weeks of age in the solid-diet group; however, no significant increase was noted in fiber types I and IC, from 4 to 33 weeks of age, in the liquid-diet group...
April 1, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28412611/hypermethylation-of-death-associated-protein-kinase-dapk1-and-its-association-with-oral-carcinogenesis-an-experimental-and-meta-analysis-study
#10
Chinchu Jayaprakash, Vinay Koshy Varghese, Ravishankara Bellampalli, Raghu Radhakrishnan, Satadru Ray, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
OBJECTIVES: The value of abnormal DNA methylation of DAPK1 promoter and its association with various cancers have been suggested in the literature. To establish the significance of DNA methylation of DAPK1 promoter in oral squamous cell carcinoma (OSCC), we a) performed a case-control study, b) evaluated published data for its utility in the diagnosis and prognosis of OSCC and c) identified the association of DAPK1 gene expression with promoter DNA methylation status. DESIGN: Bisulfite gene sequencing of DAPK1 promoter region was performed on non-malignant and malignant oral samples...
March 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28399471/cigarette-smoke-extract-cse-induces-rage-mediated-inflammation-in-the-ca9-22-gingival-carcinoma-epithelial-cell-line
#11
Nolan T Sanders, Derek J Dutson, Justin W Durrant, Joshua B Lewis, Shalene H Wilcox, Duane R Winden, Juan A Arroyo, Benjamin T Bikman, Paul R Reynolds
OBJECTIVE: The oral environment is anatomically positioned as a significant gateway for exposure to environmental toxicants. Cigarette smoke exposure compromises oral health by orchestrating inflammation. The receptor for advanced glycation end-products (RAGE) has been implicated in smoke-induced inflammatory effects; however, its role in the oral cavity is unknown. The purpose of this study was to determine RAGE expression by immortalized gingival carcinoma cells and the degree to which RAGE-mediated signaling influences inflammation...
March 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28395167/the-association-of-enamelin-lactoferrin-and-tumour-necrosis-factor-alpha-gene-polymorphisms-with-high-caries-susceptibility-in-chinese-children-under-4-years-old
#12
Mengchen Wang, Man Qin, Bin Xia
OBJECTIVE: The aim of this study was to assess the role of ENAM rs3796703, LTF rs1126478, and TNF-α rs1800629 in high caries susceptibility. DESIGN: The present case-control study included 1005 unrelated children under 4 years old: 505 with severe caries (dmft index ≥4) and 500 who were caries-free (dmft index=0 and without white-spot lesions). Questionnaires were obtained from parents and gardians about the children's diet and oral behavioural habits. All the children received dental examinations and oral swabbing for human genomic DNA collection...
March 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28414988/response-of-mandibular-condyles-of-juvenile-and-adult-rats-to-abnormal-occlusion-and-subsequent-exemption
#13
Guang Zeng, Bin Kuang, Wen-Xing Xun, Gao-Tong Ren, Ke-Wen Wei
OBJECTIVE: The adaptation capacities of the mandibular condyle in response to mechanical stimuli might be different between juveniles and adults, but has not been compared. This study aimed to investigate whether abnormal molar occlusion and subsequent molar extraction could lead to different remodeling responses in the mandibular condyles of juvenile and adult rats. METHODS: Abnormal molar occlusion (AMO) was established in the 5- and 16-wk old rats by moving their maxillary left and mandibular right third molars distally...
March 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28384521/rna-isolation-from-alveolar-bone-and-gene-expression-analysis-of-rank-rankl-and-opg-a-new-tool-to-monitor-bone-remodeling-and-healing-in-different-bone-substitutes-used-for-prosthetic-rehabilitation
#14
Elena Canciani, Claudia Dellavia, Monica Gioia Marazzi, Davide Augusti, Daniela Carmagnola, Elena Vianello, Luigi Canullo, Emanuela Galliera
OBJECTIVE: (i) To validate a simple and efficient method for extracting high quality RNA from small samples of bone tissue, (ii) to test its application on limited amounts of grafted oral bone and (iii) to analyze the gene expression of the OPG/RANK/RANKL system and IL-6 in "spontaneous healing" and grafted tissue. DESIGN: 26 patients in need of extraction of one lower molar tooth were divided in 3 groups. In group A (8 patients) the alveolar socket was left for spontaneous healing, in group B (8 patients) it was filled with a hydroxyapatite scaffold while in group C (10 patients) it was filled with hydroxyapatite granules...
March 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28366785/de-novo-synthetic-short-antimicrobial-peptides-against-cariogenic-bacteria
#15
Yufei Wang, Yingying Fan, Zhengli Zhou, Huanxin Tu, Qian Ren, Xiuqing Wang, Longjiang Ding, Xuedong Zhou, Linglin Zhang
OBJECTIVE: Antimicrobial peptides (AMPs) have shown the ability to inhibit planktonic bacteria and biofilms. The objectives of this study were to de novo design and synthesize a series of cationic, amphipathic α-helical AMPs that would be shorter, less cytotoxic, and more potent than existing AMPs against cariogenic bacteria. DESIGN: Three short AMPs (GH8, GLLWHLLH-NH2; GH12, GLLWHLLHHLLH-NH2; and GH16, GLLWHLLHHLLHLLHH-NH2) were designed, synthesized and characterized structurally...
March 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28391087/effects-of-two-wattages-of-low-level-laser-therapy-on-orthodontic-tooth-movement
#16
M Milligan, Y Arudchelvan, S-G Gong
INTRODUCTION: Mixed outcomes have been found in animal and clinical studies with regard to the use of low-level laser therapy (LLLT) as a modality to accelerate orthodontic tooth movement (OTM). One major reason for the variable findings is the different methodologies and protocols for laser therapy use. OBJECTIVE: The aim of this study was to determine whether orthodontically moved molars exposed to two different wattages at the same energy density of LLLT exhibited differences in the amount of tooth movement and molecular and histological changes in the adjacent periodontal areas...
March 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28371626/correlation-between-numbers-of-cells-in-human-dental-pulp-and-age-implications-for-age-estimation
#17
Mohammad Zakir Hossain, Sulinda Daud, Phrabhakaran Nambiar, Fathilah Abdul Razak, Norintan Ab-Murat, Roslan Saub, Marina M Bakri
OBJECTIVE: The aim of this study was to investigate correlations between dental pulp cell count of odontoblasts, subodontoblasts and fibroblasts and age, within different age groups. Formulation of regression equations using the dental pulp cell count for predicting age was attempted. DESIGN: Eighty-one extracted teeth were grouped into two age groups (6-25 years, 26-80 years). The teeth were demineralized and histological sections were prepared for cell count. Regression equations were generated from regression analysis of cell count and tested for age estimation...
March 24, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28364672/efficacy-of-a-mouthrinse-based-on-hydroxyapatite-to-reduce-initial-bacterial-colonisation-in-situ
#18
A Kensche, C Holder, S Basche, N Tahan, C Hannig, M Hannig
OBJECTIVE: The present in situ - investigation aimed to specify the impact of pure hydroxyapatite microclusters on initial bioadhesion and bacterial colonization at the tooth surface. DESIGN: Pellicle formation was carried out in situ on bovine enamel slabs (9 subjects). After 1min of pellicle formation rinses with 8ml of hydroxyapatite (HA) microclusters (5%) in bidestilled water or chlorhexidine 0.2% were performed. As negative control no rinse was adopted. In situ biofilm formation was promoted by the intraoral slab exposure for 8h overnight...
March 23, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28347886/immunohistochemical-expression-of-epithelial-cell-adhesion-molecule-epcam-in-mucoepidermoid-carcinoma-compared-to-normal-salivary-gland-tissues
#19
Noura M Kamal, Hend M Salem, Heba M Dahmoush
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor which displays biological, histological and clinical diversity thus representing a challenge for its diagnosis and management. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein identified as a tumor specific antigen due to its frequent overexpression in the majority of epithelial carcinomas and its correlation with prognosis. It is considered to be a promising biomarker used as a therapeutic target already in ongoing clinical trials...
March 21, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28351666/operculina-turpethum-extract-inhibits-growth-and-proliferation-by-inhibiting-nf-%C3%AE%C2%BAb-cox-2-and-cyclin-d1-and-induces-apoptosis-by-up-regulating-p53-in-oral-cancer-cells
#20
Ritu Arora, Vijaya Bharti, Poonam Gaur, Sadhna Aggarwal, Manasi Mittal, Satya N Das
OBJECTIVES: Herbal drugs are popularly emerging as complementary and alternative medicines in cancer patients because of their cost effectiveness and minimal side-effects. The extract of Operculina turpethum (OT) is known to have antipyretic, anti-inflammatory and purgative properties. Since it is popularly known have antiinflammatory activity, we investigated its anti-tumor activity on four oral squamous cell carcinoma cell lines (OSCC) namely, (SCC-4, KB, SCC-9 and SCC-25). DESIGN: Antitumor activities of Operculina turpathum extract (OTE) was investigated by MTT and clonogenic assay, effect on cell cycle and apoptosis induction by Annexin-V/propidium iodide (PI) staining and flow cytometry and invasive potential of the tumor was determined by matrigel assay...
March 20, 2017: Archives of Oral Biology
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