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Journals Archivum Immunologiae et Thera...

Archivum Immunologiae et Therapiae Experimentalis

https://read.qxmd.com/read/37060455/omics-are-getting-us-closer-to-understanding-iga-nephropathy
#21
REVIEW
Krzysztof Mucha, Michał Pac, Leszek Pączek
During the last decade, thanks to omics technologies, new light has been shed on the pathogenesis of many diseases. Genomics, epigenomics, transcriptomics, and proteomics have helped to provide a better understanding of the origin and heterogeneity of several diseases. However, the risk factors for most autoimmune diseases remain unknown. The successes and pitfalls of omics have also been observed in nephrology, including immunoglobulin A nephropathy (IgAN), the most common form of glomerulonephritis and a principal cause of end-stage renal disease worldwide...
April 15, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/37038035/mast-cells-and-resistance-to-immunotherapy-in-cancer
#22
REVIEW
Domenico Ribatti
Mast cells are involved in tumor growth and their mediators exert both pro- and anti-tumorigenic roles in different human cancers. The identification of defined immunosuppressive pathways that are present in the tumor microenvironment has pointed therapeutic strategies that may promote inflammation and/or innate immune activation in this context. Mast cells can contribute to the immune suppressive tumor microenvironment and may also enhance anti-tumor responses. This review article is focused on the analysis of the mechanisms of the role of mast cells in resistance to immunotherapy in cancer...
April 11, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36964399/effect-of-hematopoietic-stem-cell-transplantation-and-post-transplantation-cyclophosphamide-on-the-microglia-phenotype-in-rats-with-experimental-allergic-encephalomyelitis
#23
JOURNAL ARTICLE
Kaja Kasarełło, Martyna Seta, Dorota Sulejczak, Emilian Snarski, Agnieszka Cudnoch-Jędrzejewska
Microglia are the resident immune cells of the central nervous system, playing a role in the inflammatory process development and resolution, presenting two main phenotypes, pro-inflammatory M1, and anti-inflammatory M2. Therapies affecting the microglia phenotype may be beneficial in treating inflammatory neurodegenerative diseases. In our experiments, we used the animal multiple sclerosis model, experimental allergic encephalomyelitis (EAE). Rats were treated during the pre- or symptomatic phase of the disease with cyclophosphamide, followed by hematopoietic stem cell transplantation, and with/without post-transplantation cyclophosphamide...
March 24, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36899273/activating-nkg2c-receptor-functional-characteristics-and-current-strategies-in-clinical-applications
#24
REVIEW
Jagoda Siemaszko, Aleksandra Marzec-Przyszlak, Katarzyna Bogunia-Kubik
The interest in NK cells and their cytotoxic activity against tumour, infected or transformed cells continuously increases as they become a new efficient and off-the-shelf agents in immunotherapies. Their actions are balanced by a wide set of activating and inhibitory receptors, recognizing their complementary ligands on target cells. One of the most studied receptors is the activating CD94/NKG2C molecule, which is a member of the C-type lectin-like family. This review is intended to summarise latest research findings on the clinical relevance of NKG2C receptor and to examine its contribution to current and potential therapeutic strategies...
March 10, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36853269/the-effects-of-statins-on-respiratory-symptoms-and-pulmonary-fibrosis-in-covid-19-patients-with-diabetes-mellitus-a-longitudinal-multicenter-study
#25
JOURNAL ARTICLE
Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Tania Dehesh, Nima Taefehshokr, Adel Sadeghdoust, Katarzyna Kotfis, Amirhossein Hashemiattar, Amir Ravandi, Neda Aligolighasemabadi, Omid Vakili, Beniamin Grabarek, Rafał Staszkiewicz, Marek J Łos, Pooneh Mokarram, Saeid Ghavami
The aim of this prospective cohort study was to explore the effect of statins on long-term respiratory symptoms and pulmonary fibrosis in coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM). Patients were recruited from three tertiary hospitals, categorized into Statin or Non-statin groups, and assessed on days 0, 28, and 90 after symptoms onset to record the duration of symptoms. Pulmonary fibrosis was scored at baseline and follow-up time points by high-resolution computed tomography scans...
February 28, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36810662/immunity-in-sars-cov-2-infection-clarity-or-mystery-a-broader-perspective-in-the-third-year-of-a-worldwide-pandemic
#26
REVIEW
Katarzyna Kapten, Krzysztof Orczyk, Elzbieta Smolewska
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its mechanisms have been thoroughly studied by researchers all over the world with the hope of finding answers that may aid the discovery of new treatment options or effective means of prevention. Still, over 2 years into the pandemic that is an immense burden on health care and economic systems, there seem to be more questions than answers. The character and multitude of immune responses elicited in coronavirus disease 2019 (COVID-19) vary from uncontrollable activation of the inflammatory system, causing extensive tissue damage and consequently leading to severe or even fatal disease, to mild or asymptomatic infections in the majority of patients, resulting in the unpredictability of the current pandemic...
February 21, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36807774/a-comprehensive-study-on-the-anti-cancer-effects-of-quercetin-and-its-epigenetic-modifications-in-arresting-progression-of-colon-cancer-cell-proliferation
#27
JOURNAL ARTICLE
Meenu Bhatiya, Surajit Pathak, Ganesan Jothimani, Asim K Duttaroy, Antara Banerjee
Colon cancer etiology involves a wide spectrum of genetic and epigenetic alterations, finding it challenging to find effective therapeutic strategies. Quercetin exhibits potent anti-proliferative/apoptotic properties. In the present study, we aimed to elucidate the anti-cancer and anti-aging effect of quercetin in colon cancer cell lines. The anti-proliferative effect of quercetin was assessed in vitro by CCK-8 in normal and colon cancer cell lines. To check the anti-aging potential of quercetin, collagenase, elastase, and hyaluronidase inhibitory activity assays were performed...
February 20, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36729313/heterogeneity-of-extracellular-vesicles-and-particles-molecular-voxels-in-the-blood-borne-hologram-of-organ-function-disfunction-and-cancer
#28
REVIEW
Janusz Rak, Leon Strzadala
Extracellular vesicles (EVs) and particles (EPs) serve as unique carriers of complex molecular information with increasingly recognized roles in health and disease. Individual EVs/EPs collectively contribute to the molecular fingerprint of their producing cell, reflecting its identity, state, function and phenotype. This property is of particular interest in cancer where enormous heterogeneity of cancer cells is compounded by the presence of altered stromal, vascular and immune cell populations, which is further complicated by systemic responses elicited by the disease in individual patients...
February 2, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36725744/ly-6a-induced-growth-inhibition-and-cell-death-in-a-transformed-cd4-t-cell-line-role-of-tumor-necrosis-factor-%C3%AE
#29
JOURNAL ARTICLE
Akshay G Patel, Sarah Moxham, Anil K Bamezai
Ly-6A, a member of the Ly-6/uPAR supergene family of proteins, is a cell adhesion and cell signaling protein. Signaling through Ly-6A activates the cell-intrinsic apoptotic cell death pathway in CD4+ T cell lines, as indicated by the release of cytochrome C, and activation of caspases 9 and 3. In addition, Ly-6A induces cytokine production and growth inhibition. The mechanism underlying the distinct cellular responses that are triggered by engaging Ly-6A protein has remained unknown. To examine the relatedness of these distinct responses, we have quantified the production of pro-apoptotic, growth inhibitory and tumor suppressive cytokines, such as TNF-α, TGF-β and a related protein GDF-10, in response to Ly-6A signaling...
February 1, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36681768/stress-sensitive-regulators-of-fetal-neurodevelopment-in-hiv-and-preeclampsia-an-immunocytochemical-appraisal-of-placental-ogt-and-t4-levels
#30
JOURNAL ARTICLE
Philemon D Shallie, Thajasvarie Naicker, Nihar R Nayak
Preeclampsia and HIV are a significant burden to maternal health globally, especially in low-middle income countries such as South Africa. In the KwaZulu-Natal province, SA antenatal HIV prevalence is 41.1%, while PE is 12%. PE and HIV infections are maternal stress and inflammation that impact placental function and fetal development. Therefore, this study investigated the impact of the comorbidity of PE and HIV on placental stress and neurodevelopment. Placentae were obtained from four cohorts of pregnant women: normotensive HIV negative, normotensive HIV positive, preeclamptic HIV negative, and preeclamptic HIV positive...
January 21, 2023: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36575342/an-assessment-of-the-serum-activity-of-adh-and-aldh-in-patients-with-primary-biliary-cholangitis
#31
JOURNAL ARTICLE
Blanka Wolszczak-Biedrzycka, Anna Bieńkowska, Elżbieta Zasimowicz, Grzegorz Biedrzycki, Justyna Dorf, Wojciech Jelski
Primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis) is a chronic inflammation-induced cholestatic process in the liver. Antimitochondrial antibodies (AMAs) are observed in around 90% of patients, which suggests that PBC is an autoimmune disease. Alcohol dehydrogenase (ADH), ADH isoenzymes and aldehyde dehydrogenase (ALDH) are localized in the liver, and they are useful markers of liver dysfunction. In this study, the activity of total ADH, ADH isoenzymes and ALDH was evaluated in the blood serum of patients with PBC...
December 28, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36528821/impact-of-betamethasone-pretreatment-on-engrafment-of-cord-blood-derived-hematopoietic-stem-cells
#32
JOURNAL ARTICLE
David Perna-Barrull, Laia Gomez-Muñoz, Silvia Rodriguez-Fernandez, Anna Gieras, Rosa M Ampudia-Carrasco, Lidia Almenara-Fuentes, Ruth M Risueño, Sergi Querol, Eva Tolosa, Marta Vives-Pi
Hematopoietic stem cell (HSC) transplantation is crucial to cure hematologic malignancies. Umbilical cord blood (UCB) is a source of stem cells, but 90% of UCB units are discarded due to low cellularity. Improving the engraftment capacities of CD34+ stem cells would allow the use of UCB that were so far rejected. Betamethasone induces long-term transcriptomic and epigenomic changes in immune cells through glucocorticoid receptor. We hypothesize that discarded UCB could be used owing to improvements induced by betamethasone...
December 18, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36342560/application-of-metabolomics-in-childhood-leukemia-diagnostics
#33
REVIEW
Agata Kozioł, Małgorzata Pupek
Metabolomics is a new field of science dealing with the study and analysis of metabolites formed in living cells. The biological fluids used in this test method are: blood, blood plasma, serum, cerebrospinal fluid, saliva and urine. The most popular methods of assessing the composition of metabolites include nuclear magnetic resonance spectroscopy and mass spectrometry (MS) in combination with gas chromatography-MS or liquid chromatography-MS. Metabolomics is used in many areas of medicine. The variability of biochemical processes in neoplastic cells in relation to healthy cells is the starting point for this type of research...
November 7, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36318344/small-extracellular-vesicles-loaded-with-immunosuppressive-mirnas-leads-to-an-inhibition-of-dendritic-cell-maturation
#34
JOURNAL ARTICLE
Liliana Czernek, Łukasz Pęczek, Markus Düchler
In particular conditions, inhibition of an immune response is required to prevent tissue damage. Among these conditions are diseases caused by an over-reactive immune response, such as autoimmune or allergic disorders, or imminent organ rejection after transplantation. To avoid tissue damage, drug-mediated systemic immune suppression is an option, but it comes with high costs in the form of susceptibility to viral and bacterial infections. Thus, the induction of antigen-specific tolerance is preferable. Extracellular vesicles (EVs) are capable of delivering antigen together with immunosuppressive signals and may be used to specifically induce antigen-specific tolerance...
November 1, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36245042/what-has-immunology-brought-to-periodontal-disease-in-recent-years
#35
REVIEW
Jan Kowalski, Maciej Nowak, Bartłomiej Górski, Renata Górska
Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanisms are being raised. Among them, the greatest attention is paid to the influence of host response on the clinical manifestations of the disease. Numerous studies have proved that the shift from gingivitis to periodontitis is not a simple progress of the disease, but an event occurring only in susceptible individuals...
October 16, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36219249/interleukin-35-has-a-protective-role-in-infectious-mononucleosis-induced-liver-inflammation-probably-by-inhibiting-cd8-t-cell-function
#36
JOURNAL ARTICLE
Ying Gao, Lan Li, Xingxing Hu, Weihua Zhang, Yu Li
Interleukin (IL)-35 plays an immunosuppressive role in infectious diseases, autoimmune disorders, and cancers. However, IL-35 expression and its regulation of CD8+ T cells in infectious mononucleosis (IM) are not fully understood. In this study, three groups of participants were compared, including twenty-three patients of IM without liver inflammation, twenty-eight patients of IM with liver inflammation, and twenty-one controls. Plasma and peripheral blood mononuclear cells (PBMCs) were isolated. CD8+ T cells were purified...
October 11, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36181646/bisphenol-a-potential-factor-of-miscarriage-in-women-in-the-context-of-the-phenomenon-of-neutrophil-extracellular-traps
#37
JOURNAL ARTICLE
Wioleta Justyna Omeljaniuk, Angelika Edyta Charkiewicz, Marzena Garley, Wioletta Ratajczak-Wrona, Jan Czerniecki, Ewa Jabłońska, Marzanna Cechowska-Pasko, Wojciech Miltyk
Humans are exposed to a number of environmental pollutants every day. Among them, endocrine disruptors are particularly harmful to human health. Bisphenol A (BPA) is a xenoestrogen that has been shown to disrupt the endocrine system and cause reproductive toxicity. In this study, we aimed to verify the potential relationship between BPA and miscarriage involving the formation of neutrophil extracellular traps (NETs). Blood samples were collected from healthy women and women who had miscarriage in the first trimester of pregnancy...
October 1, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36152104/angiotensin-ii-type-1-receptor-antibodies-are-higher-in-lupus-nephritis-and-vasculitis-than-other-glomerulonephritis-patients
#38
JOURNAL ARTICLE
Maciej Szymczak, Harald Heidecke, Marcelina Żabińska, Dagna Rukasz, Krzysztof Wiśnicki, Andrzej Tukiendorf, Magdalena Krajewska, Mirosław Banasik
Angiotensin II type 1 receptor (AT1R) antibodies are considered non-HLA (human leukocyte antigen) antibodies connected with humoral rejection after kidney transplantation. The role of AT1R antibodies in the pathogenesis of glomerular diseases and systemic vasculitis is unknown. We assessed the level of AT1R antibodies in 136 patients with different types of glomerulonephritis and systemic vasculitis and we observed kidney function and proteinuria, serum albumin and total protein levels for 2 years. The mean levels of AT1R antibodies were the following: 6...
September 24, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36152078/correction-to-cd5l-secreted-by-macrophage-on-atherosclerosis-progression-based-on-lipid-metabolism-induced-inflammatory-damage
#39
Liang Wang, Lijuan Liu, Wei Qian, Zeqi Zheng
No abstract text is available yet for this article.
September 24, 2022: Archivum Immunologiae et Therapiae Experimentalis
https://read.qxmd.com/read/36136146/monitoring-of-soluble-forms-of-baff-system-baff-april-sr-baff-staci-and-sbcma-in-kidney-transplantation
#40
JOURNAL ARTICLE
Rafael Alfaro, Santiago Llorente, Pedro Martinez, Víctor Jimenez-Coll, Helios Martínez-Banaclocha, José Antonio Galián, Carmen Botella, María Rosa Moya-Quiles, Jesús de la Peña-Moral, Alfredo Minguela, Isabel Legaz, Manuel Muro
BAFF system plays an essential role in B cells homeostasis and tolerance, although it has widely not been tested in transplantation with doubtful results. The main purpose was to study the BAFF soluble forms and their correlation with acute rejection (AR) and donor-specific antibodies production. Serum levels of BAFF, APRIL, and soluble forms of their receptors were analyzed in renal recipients with and without acute rejection (AR/NAR) appearance. All molecules were evaluated at pre- and post-transplantation...
September 22, 2022: Archivum Immunologiae et Therapiae Experimentalis
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