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Archivum Immunologiae et Therapiae Experimentalis

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https://www.readbyqxmd.com/read/30386868/roles-of-myeloid-derived-suppressor-cells-in-cancer-metastasis-immunosuppression-and-beyond
#1
REVIEW
Amin Pastaki Khoshbin, Mahsa Eskian, Mahsa Keshavarz-Fathi, Nima Rezaei
Metastasis is the direst face of cancer, and it is not a feature solely dependent on cancer cells; however, a complex interaction between cancer cells and host causes this process. Investigating the mechanisms of metastasis can lead to its control. Myeloid-derived suppressor cells (MDSCs) are key components of tumor microenvironment that favor cancer progression. These cells result from altered myelopoiesis in response to the presence of tumor. The most recognized function of MDSCs is suppressing anti-tumor immune responses...
November 2, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30374518/characterization-of-regulatory-t-cells-in-preterm-and-term-infants
#2
Asmaa M Zahran, Khaled Saad, Yasser F Abdel-Raheem, Khalid I Elsayh, Amira A El-Houfey, Mohamed Diab Aboul-Khair, Mohamd A Alblihed
Our study aimed to study regulatory T cells (Tregs) and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. In an observational study, we used a three-color flow cytometry for determination of Tregs and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. The percentages of CD4+ CD25+high Foxp3+ , CD39+ Tregs, HLA-DR+ Tregs and the expression of Foxp3+ in CD4+ CD25+high Foxp3 Tregs cells were significantly lower in neonates when compared to healthy adult controls...
October 29, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30327837/building-the-prestige-of-archivum-immunologiae-et-therapiae-experimentalis-from-a-little-known-to-an-internationally-recognized-journal
#3
EDITORIAL
Hubert Krotkiewski, Andrzej Górski, Michał Zimecki
Archivum Immunologiae et Therapiae Experimentalis (AITE) was founded in 1953 by Ludwik Hirszfeld, a world famous Polish physician and scientist in the field of microbiology and immunology. Initially, AITE was published in Polish, but within a few years, it changed to English to increase the range and number of international readers. In its over 65 year history, AITE has had several Editors and a number of Publishers. In the period 1977-1991, AITE was listed in the system of scientific information Current Contents/Life Sciences, but for several years, its impact on the international readership of the Journal was negligible...
October 16, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30302512/human-microbiome-composition-and-role-in-inflammatory-skin-diseases
#4
REVIEW
Anna Balato, Sara Cacciapuoti, Roberta Di Caprio, Claudio Marasca, Anna Masarà, Annunziata Raimondo, Gabriella Fabbrocini
This review focuses on recent evidences about human microbiome composition and functions, exploring the potential implication of its impairment in some diffuse and invalidating inflammatory skin diseases, such as atopic dermatitis, psoriasis, hidradenitis suppurativa and acne. We analysed current scientific literature, focusing on the current evidences about gut and skin microbiome composition and the complex dialogue between microbes and the host. Finally, we examined the consequences of this dialogue for health and skin diseases...
October 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30291393/interleukin-22-and-its-correlation-with-disease-activity-in-plaque-psoriasis
#5
Bartłomiej Wawrzycki, Aldona Pietrzak, Ewelina Grywalska, Dorota Krasowska, Grażyna Chodorowska, Jacek Roliński
Psoriasis is a chronic debilitating skin disease with an estimated prevalence reaching 2% of the worldwide population. Psoriatic disease is driven by a network of complicated reciprocal interactions among innate and adaptive mechanisms of immune system with structural components of the skin. Interleukin (IL)-22 mediates keratinocyte proliferation and epidermal hyperplasia, inhibits terminal differentiation of keratinocytes, and induces the production of antimicrobial proteins. The aim of this study was the assessment of IL-22 levels and its correlation with disease activity in plaque psoriasis...
October 5, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30251122/precision-personalized-medicine-in-allergic-diseases-and-asthma
#6
REVIEW
Umut Can Kucuksezer, Cevdet Ozdemir, Mubeccel Akdis, Cezmi A Akdis
Like many other chronic diseases, every allergic patient has different characteristics based on clinical course, treatment responsiveness and disease outcomes, which are associated with the genetic and epigenetic control of molecular mechanisms and environment. This variability necessitates the establishment of patient-tailored and precision approaches in handling allergic disorders. Better understanding of the underlying pathophysiological mechanisms for the development of allergic disorders will provide more rationale strategies based on individual cases in controlling and treating these disorders...
September 24, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30242440/cellular-interactions-in-the-intestinal-stem-cell-niche
#7
REVIEW
Agnieszka Pastuła, Janusz Marcinkiewicz
Epithelial cells are one of the most actively cycling cells in a mammalian organism and therefore are prone to malignant transformation. Already during organogenesis, the connective tissue (mesenchyme) provides instructive signals for the epithelium. In an adult organism, the mesenchyme is believed to provide crucial regulatory signals for the maintenance and regeneration of epithelial cells. Here, we discuss the role of intestinal myofibroblasts, α-smooth muscle actin-positive stromal (mesenchymal) cells, as an important regulatory part of the intestinal stem cell niche...
September 21, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30238127/role-of-monocytes-in-the-pathogenesis-of-dengue
#8
REVIEW
Jorge Andrés Castillo, Juan Sebastián Naranjo, Mauricio Rojas, Diana Castaño, Paula Andrea Velilla
Diseases caused by dengue virus (DENV) are a major public health problem worldwide, considered one of the infections with more prevalence in tropical and subtropical zones of the world. Despite the intense research in the pathogenesis of DENV, this feature is not well understood. One of the main target cells for DENV infection is monocytes; these phagocytes can play a dual role, since they are essential to control viremia, but they also participate in the induction of tissue damage during DENV infection. Monocytes produce different pro-inflammatory cytokines and chemokines in response to infection, and also mediate endothelial damage...
September 20, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30196473/manipulation-of-non-canonical-nf-%C3%AE%C2%BAb-signaling-by-non-oncogenic-viruses
#9
REVIEW
Justyna Struzik, Lidia Szulc-Dąbrowska
Nuclear factor (NF)-κB is a major regulator of antiviral response. Viral pathogens exploit NF-κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical (classical) NF-κB signaling, which regulates innate immune response, cell survival and inflammation, is often manipulated by viral pathogens that can counteract antiviral response. Oncogenic viruses can modulate not only canonical, but also non-canonical (alternative) NF-κB activation pathways. The non-canonical NF-κB signaling is responsible for adaptive immunity and plays a role in lymphoid organogenesis, B cell development, as well as bone metabolism...
September 8, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30196472/tlr2-expression-on-leukemic-b-cells-from-patients-with-chronic-lymphocytic-leukemia
#10
Agata Szymańska, Agnieszka Bojarska-Junak, Arkadiusz Drobiecki, Waldemar Tomczak, Jacek Roliński, Marek Hus, Iwona Hus
Antigenic stimulation is considered as a possible trigger of neoplastic transformation in chronic lymphocytic leukemia (CLL). B-cell receptor plays a key role in the interactions between the microenvironment and leukemic cells; however, an important role has also been attributed to Toll-like receptors (TLRs). It is believed that disorders of TLR expression may play a part in the pathogenesis of CLL. In this study, we investigated the potential role of TLR2 in CLL by analyzing its expression on leukemic B cells in correlation with clinical and laboratory parameters characterizing disease activity and patients' immune status...
September 8, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30155762/innate-lymphoid-cells-in-inflammatory-bowel-disease
#11
REVIEW
Jian Li, Sarah C Glover
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex chronic inflammatory condition of the human gut of unknown causes. Traditionally, dysregulated adaptive immune responses are thought to play a major role; however, accumulating evidence suggests that innate immunity also contributes to this process. Innate lymphoid cells (ILCs) are recently identified important components of innate immunity. They have critical roles in immunity, tissue development and remodeling...
August 29, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30167716/celiac-disease-autoimmunity
#12
EDITORIAL
Miguel Ángel López Casado, Pedro Lorite, Candelaria Ponce de León, Teresa Palomeque, Maria Isabel Torres
Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production...
August 25, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30159581/systemic-treatment-for-severe-atopic-dermatitis
#13
REVIEW
Mara Giavina-Bianchi, Pedro Giavina-Bianchi
Atopic dermatitis (AD) is a chronic inflammatory, relapsing disease of the skin, characterized by intense pruritus, maculopapular or vesicular erythematous lesions and scaling, sometimes accompanied by oozing, crusts and/or lichenification that has a negative impact on patients' quality of life. Prevalence is higher in children, around 15%, and approximately 5% in adults. Before introducing systemic therapy, it is mandatory to review patients' adherence to the correct use of topical treatments (corticosteroids, calcineurin inhibitors or cresoborole) and/or phototherapy...
August 22, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29951696/analysis-of-polymorphisms-in-the-mediator-complex-subunit-13-like-med13l-gene-in-the-context-of-immune-function-and-development-of-experimental-arthritis
#14
Samra Sardar, Katrine Kanne, Åsa Andersson
The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations in MED13L on immune cells remains unexplored. The B10.RIII and RIIIS/J mouse strains vary in susceptibility to induced experimental autoimmune disease models...
October 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29536116/muscle-stem-progenitor-cells-and-mesenchymal-stem-cells-of-bone-marrow-origin-for-skeletal-muscle-regeneration-in-muscular-dystrophies
#15
REVIEW
Aleksandra Klimczak, Urszula Kozlowska, Maciej Kurpisz
Muscular dystrophies represent a group of diseases which may develop in several forms, and severity of the disease is usually associated with gene mutations. In skeletal muscle regeneration and in muscular dystrophies, both innate and adaptive immune responses are involved. The regenerative potential of mesenchymal stem/stromal cells (MSCs) of bone marrow origin was confirmed by the ability to differentiate into diverse tissues and by their immunomodulatory and anti-inflammatory properties by secretion of a variety of growth factors and anti-inflammatory cytokines...
October 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30076457/baicalin-attenuates-joint-pain-and-muscle-dysfunction-by-inhibiting-muscular-oxidative-stress-in-an-experimental-osteoarthritis-rat-model
#16
De-Sheng Chen, Jian-Gang Cao, Bo Zhu, Zeng-Liang Wang, Tong-Fu Wang, Jian-Jun Tang
Osteoarthritis (OA) is the most common degenerative joint disease, and causes major pain and disability in adults. It has been reported that muscle weakness and inflammation contribute to osteoarthritis development and progression. Oxidative stress plays important roles in muscle dysfunction and inflammation in osteomyelitis. Baicalin, the major active constituent of the isolated root of Scutellarialateriflora Georgi, has been shown to have anti-oxidative and anti-inflammatory effects. In this study, we evaluated the potential effects of baicalin on osteoarthritis...
August 3, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29468256/intestinal-barrier-impairment-and-immune-activation-in-hiv-infected-advanced-late-presenters-are-not-dependent-on-cd4-recovery
#17
Kamila Wójcik-Cichy, Anna Piekarska, Elżbieta Jabłonowska
Damage of the mucosal barrier in HIV infection, microbial translocation, and immune activation can persist even in patients on successful antiretroviral therapy (ART) especially advanced late presenters. The aim of this study was to find factors that determine immune activation and bacterial translocation in HIV-infected advanced late presenters on suppressive ART. Forty-three late presenters (CD4 < 200 cells/µl prior to ART) on successful ART (more than 2 years of ART) with optimal and suboptimal CD4 recovery were enrolled into this study...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29427174/adverse-effects-associated-with-clinical-applications-of-car-engineered-t-cells
#18
REVIEW
Zohreh Sadat Badieyan, Sayed Shahabuddin Hoseini
Cancer has been ranked as the second leading cause of death in the United States. To reduce cancer mortality, immunotherapy is gaining momentum among other therapeutic modalities, due to its impressive results in clinical trials. The genetically engineered T cells expressing chimeric antigen receptors (CARs) are emerging as a new approach in cancer immunotherapy, with the most successful outcomes in the refractory/relapse hematologic malignancies. However, the widespread clinical applications are limited by adverse effects some of which are life-threatening...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29411049/humanized-mice-as-unique-tools-for-human-specific-studies
#19
REVIEW
Kylie Su Mei Yong, Zhisheng Her, Qingfeng Chen
With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, "humanized" mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29404659/the-phenomenon-of-neutrophil-extracellular-traps-in-vascular-diseases
#20
REVIEW
Dorota Dąbrowska, Ewa Jabłońska, Marzena Garley, Jolanta Sawicka-Powierza, Karolina Nowak
Vascular diseases constitute a global health issue due to the increasing number of cases of patients with these diseases. The pathogenesis of the majority of these diseases, including atherosclerosis and thrombosis, is complex and not yet fully understood. One of the major causes for their occurrence can be immune disorders resulting in the development of a chronic inflammation within the vessels. In recent years, studies have placed emphasis on the role of neutrophils in the development of these diseases, i...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
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