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Archivum Immunologiae et Therapiae Experimentalis

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https://www.readbyqxmd.com/read/29992337/transplant-tolerance-current-insights-and-strategies-for-long-term-survival-of-xenografts
#1
REVIEW
Lu Liu, Chen He, Jintao Liu, Zhiwu Lv, Ganlu Wang, Hanchao Gao, Yifan Dai, David K C Cooper, Zhiming Cai, Lisha Mou
Xenotransplantation is an attractive solution to the problem of allograft shortage. However, transplants across discordant species barriers are subject to vigorous immunologic and pathobiologic hurdles, some of which might be overcome with the induction of immunologic tolerance. Several strategies have been designed to induce tolerance to a xenograft at both the central (including induction of mixed chimerism and thymic transplantation) and peripheral (including adoptive transfer of regulatory cells and blocking T cell costimulation) levels...
July 10, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29951696/analysis-of-polymorphisms-in-the-mediator-complex-subunit-13-like-med13l-gene-in-the-context-of-immune-function-and-development-of-experimental-arthritis
#2
Samra Sardar, Katrine Kanne, Åsa Andersson
The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations in MED13L on immune cells remains unexplored. The B10.RIII and RIIIS/J mouse strains vary in susceptibility to induced experimental autoimmune disease models...
June 27, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29951695/deviations-in-peripheral-blood-cell-populations-are-associated-with-the-stage-of-primary-biliary-cholangitis-and-presence-of-itching
#3
Halina Cichoż-Lach, Ewelina Grywalska, Agata Michalak, Agnieszka Kowalik, Michał Mielnik, Jacek Roliński
To evaluate the role of Th17, Treg cells, activated T CD3+ and B CD19+ lymphocytes in primary biliary cholangitis (PBC) patients. 40 female patients with PBC and 20 healthy donors were enrolled in this study. The percentages and absolute counts of Th17, Treg, activated T CD3+ , B CD19+ , NK, NKT-like lymphocytes were measured by flow cytometry. Our research revealed significantly lower frequencies and absolute counts of CD4+ CD25+ FOXP3+ Treg cells (p < 0.0001), higher percentages and absolute counts of Th17 cells (IL-17A+ CD3+ CD4+ ; p < 0...
June 27, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29796818/differences-in-the-expression-of-tlr-2-nod2-and-nf-%C3%AE%C2%BAb-in-placenta-between-twins
#4
Łukasz Szylberg, Magdalena Bodnar, Anna Lebioda, Patrycja Krepska, Adam Kowalewski, Grzegorz Bręborowicz, Andrzej Marszałek
Dizygotic twins share the same type of genetic relationship as non-twin siblings. Whereas monozygotic (MZ) twins are considered to have identical genetic material, they still differ. There is a number of reasons for early MZ twin discordance, including differences in the in utero environment, stochasticity, genetic mosaicism, and epigenetic factors. During gestation, the efficient innate immune system is of utmost importance. Our study was based on immunohistochemical evaluation of the differences in innate immune protein expression (TLR-2, NOD2, and NF-κB) in the 95 placentas between twins...
May 23, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29744553/changes-in-mirna-5196-expression-as-a-potential-biomarker-of-anti-tnf-%C3%AE-therapy-in-rheumatoid-arthritis-and-ankylosing-spondylitis-patients
#5
Marzena Ciechomska, Krzysztof Bonek, Michal Merdas, Patryk Zarecki, Jerzy Swierkot, Piotr Gluszko, Katarzyna Bogunia-Kubik, Wlodzimierz Maslinski
In this study, we analysed the expression level of sera circulating miRNA-5196 in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients before and after tumor necrosis factor (TNF)-α therapy as biomarkers predicting positive treatment outcome. We enrolled 10 RA patients, 13 AS patients, and 12 healthy individuals in the study. The expression of miRNA-5196 was measured by real-time polymerase chain reaction before and after anti-TNF-α therapy. Disease activity of RA patients was assessed using disease activity score 28 (DAS28), whereas ankylosing spondylitis DAS (ASDAS) was used in AS patients...
May 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29713726/detection-of-16%C3%AE-hydroxyestrone-histone-1-adduct-as-high-affinity-antigen-for-rheumatoid-arthritis-autoantibodies
#6
Wahid Ali Khan, Gaffar Sarwar Zaman
Increased concentrations of 16α-hydroxyestrone (16α-OHE1 ) have been observed in rheumatoid arthritis (RA), but the underlying mechanism of this remains elusive. Here we aimed to identify the role played by 16α-OHE1 in RA. In 40 RA patients, the specificities of antibodies from the sera of these patients were checked by direct binding, inhibition ELISA, and quantitative precipitation titration. Competition ELISA was also used for the estimation of 16α-OHE1 in the serum of different RA patients. RA IgG from a patient's sera showed strong recognition to 16α-OHE1 -H1 (histone 1) adduct in comparison to control subjects (p < 0...
April 30, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29704020/role-of-chicoric-acid-and-13-cis-retinoic-acid-in-mycobacterium-tuberculosis-infection-control-by-human-u937-macrophage
#7
Bahareh Abd-Nikfarjam, Marjan Nassiri-Asl, Mehri Hajiaghayi, Taghi Naserpour Farivar
Mycobacterium tuberculosis (Mtb) survives and proliferates within the main cells of the innate immune system, macrophages. The goal of our study was to investigate the immunostimulatory effects of 13-cis retinoic acid (RA) and chicoric acid (CA) in human U937 macrophages against H37Ra Mtb infection by evaluating its potential role in the cell surface expression of HLA-DR, CD14 molecules as well as nitric oxide (NO) production and prevention of the Mtb growth within macrophages. In this study, we investigated the effects of 13-cis RA and CA on Mtb-infected macrophages using flowcytometry and Griess methods, respectively...
April 27, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29256092/allergen-specific-t-cells-in-ige-mediated-food-allergy
#8
REVIEW
Aziza Saidova, Ahuva Magder Hershkop, Marta Ponce, Thomas Eiwegger
Food allergy is the major reason for severe anaphylaxis in childhood and adolescence. Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food allergens. The purpose of this review is to provide an overview on the role of allergen-specific T cells in food allergy during allergic sensitization, natural tolerance development and allergen immunotherapy. Allergen-specific T cells in the context of food allergy are predominantly of a Th2 type with slightly different surface marker expression patterns in different food allergies...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29234825/bindarit-attenuates-pain-and-cancer-related-inflammation-by-influencing-myeloid-cells-in-a-model-of-bone-cancer
#9
Shenghou Liu, Hongwei Gao, Chunzheng Gao, Wenguang Liu, Deguo Xing
C-C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. We established a bone-cancer mouse model by inoculating cancer cells. After applying Bindarit, we preformed pain sensitivity tests and checked cancer development by X-ray...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29214330/oxidative-stress-in-kidney-diseases-the-cause-or-the-consequence
#10
REVIEW
Natalia Krata, Radosław Zagożdżon, Bartosz Foroncewicz, Krzysztof Mucha
Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29209738/the-impact-of-di-2-ethylhexyl-phthalate-on-cancer-progression
#11
REVIEW
Chon-Kit Chou, Ya-Ting Yang, Ho-Chun Yang, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Hui-Min David Wang, Eing-Mei Tsai, Chien-Chih Chiu
Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, mainly serves as an additive to render polyvinyl chloride (PVC) soft and flexible. PVC plastics have become ubiquitous in our modern society. Yet, the leaching of DEHP from PVC-based consumables ultimately results in the deposition in certain tissues via inadvertent applications. Health risks for human populations exposed to DEHP has been assumed by studies on rodents and other species, including the DEHP-induced developmental dysregulation, reproductive impairments, tumorigenesis, and diseases in a transgenerational manner...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29189884/adaptive-immune-cell-dysregulation-and-role-in-acute-pancreatitis-disease-progression-and-treatment
#12
REVIEW
Pascaline Fonteh, Martin Smith, Martin Brand
Acute pancreatitis (AP) is an inflammation of the pancreas caused by various stimuli including excessive alcohol consumption, gallstone disease and certain viral infections. Managing specifically the severe form of AP is limited due to lack of an understanding of the complex immune events that occur during AP involving immune cells and inflammatory molecules such as cytokines. The relative abundance of various immune cells resulting from the immune dysregulation drives disease progression. In this review, we examine the literature on the adaptive immune cells in AP, the prognostic value of these cells in stratifying patients into appropriate care and treatment strategies based on cell frequency in different AP severities are discussed...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28975357/the-effects-of-intestinal-nematode-l4-stage-on-mouse-experimental-autoimmune-encephalomyelitis
#13
Katarzyna Donskow-Łysoniewska, Katarzyna Krawczak, Katarzyna Bocian, Maria Doligalska
Helminths use various immunomodulatory and anti-inflammatory strategies to evade immune attack by the host. During pathological conditions, these strategies alter the course of disease by reducing immune-mediated pathology. The study examines the therapeutic effect of the nematode L4 stage based on an in vivo model of multiple sclerosis, monophasic encephalomyelitis (EAE), induced by sensitization with MOG35-55 peptide in C57BL/6 female mice infected with the intestinal nematode Heligmosomoides polygyrus. The EAE remission was correlated with altered leukocyte number identified in the central nervous system (CNS), and temporary permeability of the blood-brain barrier at the histotrophic phase of infection...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28861617/novel-therapeutic-approaches-to-atopic-dermatitis
#14
REVIEW
Katarzyna Osinka, Karolina Dumycz, Bartłomiej Kwiek, Wojciech Feleszko
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. The number of people affected by AD is relatively high and seems to be rising. Although mild and moderate forms of the disease can be well controlled by the use of emollients, topical corticosteroids, and topical calcineurin inhibitors, treatment of severe is still a huge challenge. The new hope is biologic drugs, magic bullets in allergy, targeted at different points of the complex pathomechanism of inflammation in AD. In this review, novel biologic therapies are discussed, including recombinant monoclonal antibodies directed against various interleukin pathways (such as IL-4, IL-13, TSLP, IL-31, and IL-12/23), on immunoglobulin E, molecules acting as T cells, B cells, etc...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29288431/thymus-colonization-who-how-how-many
#15
REVIEW
Andreas Krueger
De novo generation of T cells depends on continual colonization of the thymus by bone marrow-derived progenitors. Thymus seeding progenitors (TSPs) constitute a heterogeneous population comprising multipotent and lineage-restricted cell types. Entry into the thymic microenvironment is tightly controlled and recent quantitative studies have revealed that the adult murine thymus only contains approximately 160 niches to accommodate TSPs. Of these niches only about 6% are open for seeding on average at steady-state...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29032490/myeloid-derived-suppressor-cells-in-the-tumor-microenvironment-current-knowledge-and-future-perspectives
#16
REVIEW
Maria Ibáñez-Vea, Miren Zuazo, Maria Gato, Hugo Arasanz, Gonzalo Fernández-Hinojal, David Escors, Grazyna Kochan
The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main suppressive mechanisms used by these cell subsets in tumor-bearing hosts. As a result of the identification of protein targets responsible for MDSCs suppressive activity, different therapeutics agents have been used to eliminate/reduce their adverse effect...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29026920/immunotherapy-as-an-option-for-cancer-treatment
#17
REVIEW
Tillmann Rusch, Jagadeesh Bayry, Jens Werner, Ivan Shevchenko, Alexandr V Bazhin
The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the field of cancer immunotherapy. Currently, there is a wide variety of immunotherapeutic approaches and critical improvements are continually being made. Among different immunotherapeutic strategies, therapies based on the blockade of immune checkpoint molecules have shown unparalleled efficacy in late-stage cancer patients...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28951939/biological-and-pro-angiogenic-properties-of-genetically-modified-human-primary-myoblasts-overexpressing-placental-growth-factor-in-in-vitro-and-in-vivo-studies
#18
Agnieszka Zimna, Bartosz Wiernicki, Tomasz Kolanowski, Natalia Rozwadowska, Agnieszka Malcher, Wojciech Labedz, Tomasz Trzeciak, Katarzyna Chojnacka, Katarzyna Bednarek-Rajewska, Przemyslaw Majewski, Maciej Kurpisz
Cardiovascular diseases are a growing problem in developing countries; therefore, there is an ongoing intensive search for new approaches to treat these disorders. Currently, cellular therapies are focused on healing the damaged heart by implanting stem cells modified with pro-angiogenic factors. This approach ensures that the introduced cells are capable of fulfilling the complex requirements of the environment, including the replacement of the post-infarction scar with cells that are able to contract and promote the formation of new blood vessels that can supply the ischaemic region with nutrients and oxygen...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28770269/the-pd-1-pd-l1-inhibitory-pathway-is-altered-in-primary-glomerulonephritides
#19
Ewelina Grywalska, Iwona Smarz-Widelska, Ewelina Krasowska-Zajac, Izabela Korona-Glowniak, Karolina Zaluska-Patel, Michal Mielnik, Martyna Podgajna, Anna Malm, Jacek Rolinski, Wojciech Zaluska
The pathogenesis of primary proliferative and non-proliferative glomerulonephritides (PGN and NPGN) is still not fully understood, however, current evidence suggests that most cases of PGN and NPGN are the results of immunologic response to different etiologic agents that activates various biological processes leading to glomerular inflammation and injury. Programmed cell death protein 1 (PD-1) is the major inhibitory receptor regulating T cell exhaustion. The aim of this study was to evaluate the frequencies of PD-1-positive and PD-ligand 1 (PD-L1)-positive T and B lymphocytes in patients with NPGN and PGN in relation to clinical parameters for the first time...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28748479/sting-signaling-in-cancer-cells-important-or-not
#20
REVIEW
Olga Sokolowska, Dominika Nowis
Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. However, little is known about the consequences of activated STING-mediated signaling in cancer cells on the efficacy of the antitumor treatment...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
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