journal
MENU ▼
Read by QxMD icon Read
search

Archivum Immunologiae et Therapiae Experimentalis

journal
https://www.readbyqxmd.com/read/29744553/changes-in-mirna-5196-expression-as-a-potential-biomarker-of-anti-tnf-%C3%AE-therapy-in-rheumatoid-arthritis-and-ankylosing-spondylitis-patients
#1
Marzena Ciechomska, Krzysztof Bonek, Michal Merdas, Patryk Zarecki, Jerzy Swierkot, Piotr Gluszko, Katarzyna Bogunia-Kubik, Wlodzimierz Maslinski
In this study, we analysed the expression level of sera circulating miRNA-5196 in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients before and after tumor necrosis factor (TNF)-α therapy as biomarkers predicting positive treatment outcome. We enrolled 10 RA patients, 13 AS patients, and 12 healthy individuals in the study. The expression of miRNA-5196 was measured by real-time polymerase chain reaction before and after anti-TNF-α therapy. Disease activity of RA patients was assessed using disease activity score 28 (DAS28), whereas ankylosing spondylitis DAS (ASDAS) was used in AS patients...
May 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29713726/detection-of-16%C3%AE-hydroxyestrone-histone-1-adduct-as-high-affinity-antigen-for-rheumatoid-arthritis-autoantibodies
#2
Wahid Ali Khan, Gaffar Sarwar Zaman
Increased concentrations of 16α-hydroxyestrone (16α-OHE1 ) have been observed in rheumatoid arthritis (RA), but the underlying mechanism of this remains elusive. Here we aimed to identify the role played by 16α-OHE1 in RA. In 40 RA patients, the specificities of antibodies from the sera of these patients were checked by direct binding, inhibition ELISA, and quantitative precipitation titration. Competition ELISA was also used for the estimation of 16α-OHE1 in the serum of different RA patients. RA IgG from a patient's sera showed strong recognition to 16α-OHE1 -H1 (histone 1) adduct in comparison to control subjects (p < 0...
April 30, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29704020/role-of-chicoric-acid-and-13-cis-retinoic-acid-in-mycobacterium-tuberculosis-infection-control-by-human-u937-macrophage
#3
Bahareh Abd-Nikfarjam, Marjan Nassiri-Asl, Mehri Hajiaghayi, Taghi Naserpour Farivar
Mycobacterium tuberculosis (Mtb) survives and proliferates within the main cells of the innate immune system, macrophages. The goal of our study was to investigate the immunostimulatory effects of 13-cis retinoic acid (RA) and chicoric acid (CA) in human U937 macrophages against H37Ra Mtb infection by evaluating its potential role in the cell surface expression of HLA-DR, CD14 molecules as well as nitric oxide (NO) production and prevention of the Mtb growth within macrophages. In this study, we investigated the effects of 13-cis RA and CA on Mtb-infected macrophages using flowcytometry and Griess methods, respectively...
April 27, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29541797/the-microbial-endocrinology-of-pseudomonas-aeruginosa-inflammatory-and-immune-perspectives
#4
REVIEW
Valerie F L Yong, Min Min Soh, Tavleen Kaur Jaggi, Micheál Mac Aogáin, Sanjay H Chotirmall
Pseudomonas aeruginosa is a major pathogen responsible for both acute and chronic infection. Known as a colonising pathogen of the cystic fibrosis (CF) lung, it is implicated in other settings such as bronchiectasis. It has the ability to cause acute disseminated or localised infection particularly in the immunocompromised. Human hormones have been highlighted as potential regulators of bacterial virulence through crosstalk between analogous "quorum sensing" (QS) systems present in the bacteria that respond to mammalian hormones...
March 14, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29536116/muscle-stem-progenitor-cells-and-mesenchymal-stem-cells-of-bone-marrow-origin-for-skeletal-muscle-regeneration-in-muscular-dystrophies
#5
REVIEW
Aleksandra Klimczak, Urszula Kozlowska, Maciej Kurpisz
Muscular dystrophies represent a group of diseases which may develop in several forms, and severity of the disease is usually associated with gene mutations. In skeletal muscle regeneration and in muscular dystrophies, both innate and adaptive immune responses are involved. The regenerative potential of mesenchymal stem/stromal cells (MSCs) of bone marrow origin was confirmed by the ability to differentiate into diverse tissues and by their immunomodulatory and anti-inflammatory properties by secretion of a variety of growth factors and anti-inflammatory cytokines...
March 13, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29288431/thymus-colonization-who-how-how-many
#6
REVIEW
Andreas Krueger
De novo generation of T cells depends on continual colonization of the thymus by bone marrow-derived progenitors. Thymus seeding progenitors (TSPs) constitute a heterogeneous population comprising multipotent and lineage-restricted cell types. Entry into the thymic microenvironment is tightly controlled and recent quantitative studies have revealed that the adult murine thymus only contains approximately 160 niches to accommodate TSPs. Of these niches only about 6% are open for seeding on average at steady-state...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29032490/myeloid-derived-suppressor-cells-in-the-tumor-microenvironment-current-knowledge-and-future-perspectives
#7
REVIEW
Maria Ibáñez-Vea, Miren Zuazo, Maria Gato, Hugo Arasanz, Gonzalo Fernández-Hinojal, David Escors, Grazyna Kochan
The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main suppressive mechanisms used by these cell subsets in tumor-bearing hosts. As a result of the identification of protein targets responsible for MDSCs suppressive activity, different therapeutics agents have been used to eliminate/reduce their adverse effect...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29026920/immunotherapy-as-an-option-for-cancer-treatment
#8
REVIEW
Tillmann Rusch, Jagadeesh Bayry, Jens Werner, Ivan Shevchenko, Alexandr V Bazhin
The progress in melanoma immunotherapy highlights the importance of immunotherapy for cancer treatment. Although the concept of immunotherapy emerged in the beginning of the twentieth century, the end of the century signaled the start of modern immunotherapy, which has recently allowed a staggering progress in the field of cancer immunotherapy. Currently, there is a wide variety of immunotherapeutic approaches and critical improvements are continually being made. Among different immunotherapeutic strategies, therapies based on the blockade of immune checkpoint molecules have shown unparalleled efficacy in late-stage cancer patients...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28951939/biological-and-pro-angiogenic-properties-of-genetically-modified-human-primary-myoblasts-overexpressing-placental-growth-factor-in-in-vitro-and-in-vivo-studies
#9
Agnieszka Zimna, Bartosz Wiernicki, Tomasz Kolanowski, Natalia Rozwadowska, Agnieszka Malcher, Wojciech Labedz, Tomasz Trzeciak, Katarzyna Chojnacka, Katarzyna Bednarek-Rajewska, Przemyslaw Majewski, Maciej Kurpisz
Cardiovascular diseases are a growing problem in developing countries; therefore, there is an ongoing intensive search for new approaches to treat these disorders. Currently, cellular therapies are focused on healing the damaged heart by implanting stem cells modified with pro-angiogenic factors. This approach ensures that the introduced cells are capable of fulfilling the complex requirements of the environment, including the replacement of the post-infarction scar with cells that are able to contract and promote the formation of new blood vessels that can supply the ischaemic region with nutrients and oxygen...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28770269/the-pd-1-pd-l1-inhibitory-pathway-is-altered-in-primary-glomerulonephritides
#10
Ewelina Grywalska, Iwona Smarz-Widelska, Ewelina Krasowska-Zajac, Izabela Korona-Glowniak, Karolina Zaluska-Patel, Michal Mielnik, Martyna Podgajna, Anna Malm, Jacek Rolinski, Wojciech Zaluska
The pathogenesis of primary proliferative and non-proliferative glomerulonephritides (PGN and NPGN) is still not fully understood, however, current evidence suggests that most cases of PGN and NPGN are the results of immunologic response to different etiologic agents that activates various biological processes leading to glomerular inflammation and injury. Programmed cell death protein 1 (PD-1) is the major inhibitory receptor regulating T cell exhaustion. The aim of this study was to evaluate the frequencies of PD-1-positive and PD-ligand 1 (PD-L1)-positive T and B lymphocytes in patients with NPGN and PGN in relation to clinical parameters for the first time...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28748479/sting-signaling-in-cancer-cells-important-or-not
#11
REVIEW
Olga Sokolowska, Dominika Nowis
Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. However, little is known about the consequences of activated STING-mediated signaling in cancer cells on the efficacy of the antitumor treatment...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28660349/tumor-associated-macrophages-as-target-for-antitumor-therapy
#12
REVIEW
Katarzyna Sawa-Wejksza, Martyna Kandefer-Szerszeń
It is well known that the microenvironment of solid tumors is rich in inflammatory cells that influence tumor growth and development. Macrophages, called tumor-associated macrophages (TAMs), are the most abundant immune cell population present in tumor tissue. Several studies have demonstrated that the density of TAMs is associated with a poor prognosis and positively correlates with tumor growth. Several studies have proved that TAMs may activate and protect tumor stem cells, stimulate their proliferation as well as promote angiogenesis and metastasis...
April 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29468256/intestinal-barrier-impairment-and-immune-activation-in-hiv-infected-advanced-late-presenters-are-not-dependent-on-cd4-recovery
#13
Kamila Wójcik-Cichy, Anna Piekarska, Elżbieta Jabłonowska
Damage of the mucosal barrier in HIV infection, microbial translocation, and immune activation can persist even in patients on successful antiretroviral therapy (ART) especially advanced late presenters. The aim of this study was to find factors that determine immune activation and bacterial translocation in HIV-infected advanced late presenters on suppressive ART. Forty-three late presenters (CD4 < 200 cells/µl prior to ART) on successful ART (more than 2 years of ART) with optimal and suboptimal CD4 recovery were enrolled into this study...
February 21, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29427174/adverse-effects-associated-with-clinical-applications-of-car-engineered-t-cells
#14
REVIEW
Zohreh Sadat Badieyan, Sayed Shahabuddin Hoseini
Cancer has been ranked as the second leading cause of death in the United States. To reduce cancer mortality, immunotherapy is gaining momentum among other therapeutic modalities, due to its impressive results in clinical trials. The genetically engineered T cells expressing chimeric antigen receptors (CARs) are emerging as a new approach in cancer immunotherapy, with the most successful outcomes in the refractory/relapse hematologic malignancies. However, the widespread clinical applications are limited by adverse effects some of which are life-threatening...
February 9, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29411049/humanized-mice-as-unique-tools-for-human-specific-studies
#15
REVIEW
Kylie Su Mei Yong, Zhisheng Her, Qingfeng Chen
With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, "humanized" mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans...
February 7, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29404659/the-phenomenon-of-neutrophil-extracellular-traps-in-vascular-diseases
#16
REVIEW
Dorota Dąbrowska, Ewa Jabłońska, Marzena Garley, Jolanta Sawicka-Powierza, Karolina Nowak
Vascular diseases constitute a global health issue due to the increasing number of cases of patients with these diseases. The pathogenesis of the majority of these diseases, including atherosclerosis and thrombosis, is complex and not yet fully understood. One of the major causes for their occurrence can be immune disorders resulting in the development of a chronic inflammation within the vessels. In recent years, studies have placed emphasis on the role of neutrophils in the development of these diseases, i...
February 5, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/29299615/biomedical-research-in-wroc%C3%A5-aw-a-combined-density-equalizing-mapping-and-scientometric-analysis
#17
LETTER
David A Groneberg
The aim of this study was to assess the evolution of biomedical scientific activities of Wrocław scientists in the post-war time when this field of academics was rebuilt by the works of Ludwik Hirszfeld and colleagues. Using the NewQIS platform and the Web of Science database, novel procedures such as density-equalizing mapping were combined to bibliometric tools to visualize scientific progression. In total, 10,366 biomedical research articles originating from Wrocław were identified. Since 1972, there is a steady increase in research activity with the year 2015 holding the largest number of published items (895)...
February 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28852775/natural-agents-mediated-targeting-of-histone-deacetylases
#18
REVIEW
Ammad Ahmad Farooqi, Syed Kamran-Ul-Hassan Naqvi, Aliye Aras Perk, Onur Yanar, Sobia Tabassum, Muhammad Sheeraz Ahmad, Qaisar Mansoor, Mohamed S Ashry, Muhammad Ismail, George E Naoum, Waleed O Arafat
In the past few years, basic and clinical scientists have witnessed landmark achievements in many research projects, such as those conducted by the US National Institutes of Health Roadmap Epigenomics Mapping Consortium, the International Human Epigenome Consortium, The Cancer Genome Atlas Network and the International Cancer Genome Consortium, which have provided near-complete resolution of epigenetic landscape in different diseases. Furthermore, genome sequencing of tumors has provided compelling evidence related to frequent existence of mutations in readers, erasers and writers of epigenome in different cancers...
February 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28779346/comparative-assessment-of-induced-immune-responses-following-intramuscular-immunization-with-fusion-and-cocktail-of-leif-lack-and-tsa-genes-against-cutaneous-leishmaniasis-in-balb-c-mice
#19
Nahid Maspi, Fatemeh Ghaffarifar, Zohreh Sharifi, Abdolhossein Dalimi, Mohammad Saaid Dayer
In the present study, we evaluated induced immune responses following DNA vaccine containing cocktail or fusion of LeIF, LACK and TSA genes or each gene alone. Mice were injected with 100 µg of each plasmid containing the gene of insert, plasmid DNA alone as the first control group or phosphate buffer saline as the second control group. Then, cellular and humoral responses, lesion size were measured for all groups. All vaccinated mice induced Th1 immune responses against Leishmania characterized by higher IFN-γ and IgG2a levels compared with control groups (p < 0...
February 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28733878/role-of-tgf-%C3%AE-in-self-peptide-regulation-of-autoimmunity
#20
REVIEW
Bhagirath Singh, Michael D Krawetz, Rachel M De Lima, Rinee Mukherjee, Pratibha Chaturvedi, Edwin Lee-Chan, Edward H Leiter, Kelly L Summers
Transforming growth factor (TGF)-β has been implicated in regulation of the immune system, including autoimmunity. We have found that TGF-β is readily produced by T cells following immunization with self-peptide epitopes that downregulate autoimmune responses in type 1 diabetes (T1D) prone nonobese diabetic (NOD) mice. These include multiple peptide epitopes derived from the islet β-cell antigens GAD65 (GAD65 p202-221, GAD65 p217-236), GAD67 (GAD67 p210-229, GAD67 p225-244), IGRP (IGRP p123-145, IGRP p195-214) and insulin B-chain (Ins...
February 2018: Archivum Immunologiae et Therapiae Experimentalis
journal
journal
21704
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"