Karol Gostomczyk, Jędrzej Borowczak, Marta Siekielska-Domanowska, Krzysztof Szczerbowski, Mateusz Maniewski, Mariusz Dubiel, Łukasz Szylberg, Magdalena Bodnar
The widespread occurrence of SARS-CoV-2 infections and the diverse range of symptoms have placed significant strain on healthcare systems worldwide. Pregnancy has also been affected by COVID-19, with an increased risk of complications and unfavorable outcomes for expectant mothers. Multiple studies indicate that SARS-CoV-2 can infiltrate the placenta, breach its protective barrier, and infect the fetus. Although the precise mechanisms of intrauterine transmission remain unclear, factors such as perinatal infection, macrophages, sexual intercourse, and the virus' interaction with host angiotensin-converting enzyme 2 (ACE2) and neuropilin-1 (NRP-1) proteins appear to play a role in this process...
January 1, 2024: Archivum Immunologiae et Therapiae Experimentalis