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Archivum Immunologiae et Therapiae Experimentalis

Justyna Struzik, Lidia Szulc-Dąbrowska
Nuclear factor (NF)-κB is a major regulator of antiviral response. Viral pathogens exploit NF-κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical (classical) NF-κB signaling, which regulates innate immune response, cell survival and inflammation, is often manipulated by viral pathogens that can counteract antiviral response. Oncogenic viruses can modulate not only canonical, but also non-canonical (alternative) NF-κB activation pathways. The non-canonical NF-κB signaling is responsible for adaptive immunity and plays a role in lymphoid organogenesis, B cell development, as well as bone metabolism...
September 8, 2018: Archivum Immunologiae et Therapiae Experimentalis
Agata Szymańska, Agnieszka Bojarska-Junak, Arkadiusz Drobiecki, Waldemar Tomczak, Jacek Roliński, Marek Hus, Iwona Hus
Antigenic stimulation is considered as a possible trigger of neoplastic transformation in chronic lymphocytic leukemia (CLL). B-cell receptor plays a key role in the interactions between the microenvironment and leukemic cells; however, an important role has also been attributed to Toll-like receptors (TLRs). It is believed that disorders of TLR expression may play a part in the pathogenesis of CLL. In this study, we investigated the potential role of TLR2 in CLL by analyzing its expression on leukemic B cells in correlation with clinical and laboratory parameters characterizing disease activity and patients' immune status...
September 8, 2018: Archivum Immunologiae et Therapiae Experimentalis
Jian Li, Sarah C Glover
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex chronic inflammatory condition of the human gut of unknown causes. Traditionally, dysregulated adaptive immune responses are thought to play a major role; however, accumulating evidence suggests that innate immunity also contributes to this process. Innate lymphoid cells (ILCs) are recently identified important components of innate immunity. They have critical roles in immunity, tissue development and remodeling...
August 29, 2018: Archivum Immunologiae et Therapiae Experimentalis
Miguel Ángel López Casado, Pedro Lorite, Candelaria Ponce de León, Teresa Palomeque, Maria Isabel Torres
Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production...
August 25, 2018: Archivum Immunologiae et Therapiae Experimentalis
Mara Giavina-Bianchi, Pedro Giavina-Bianchi
Atopic dermatitis (AD) is a chronic inflammatory, relapsing disease of the skin, characterized by intense pruritus, maculopapular or vesicular erythematous lesions and scaling, sometimes accompanied by oozing, crusts and/or lichenification that has a negative impact on patients' quality of life. Prevalence is higher in children, around 15%, and approximately 5% in adults. Before introducing systemic therapy, it is mandatory to review patients' adherence to the correct use of topical treatments (corticosteroids, calcineurin inhibitors or cresoborole) and/or phototherapy...
August 22, 2018: Archivum Immunologiae et Therapiae Experimentalis
De-Sheng Chen, Jian-Gang Cao, Bo Zhu, Zeng-Liang Wang, Tong-Fu Wang, Jian-Jun Tang
Osteoarthritis (OA) is the most common degenerative joint disease, and causes major pain and disability in adults. It has been reported that muscle weakness and inflammation contribute to osteoarthritis development and progression. Oxidative stress plays important roles in muscle dysfunction and inflammation in osteomyelitis. Baicalin, the major active constituent of the isolated root of Scutellarialateriflora Georgi, has been shown to have anti-oxidative and anti-inflammatory effects. In this study, we evaluated the potential effects of baicalin on osteoarthritis...
August 3, 2018: Archivum Immunologiae et Therapiae Experimentalis
Lu Liu, Chen He, Jintao Liu, Zhiwu Lv, Ganlu Wang, Hanchao Gao, Yifan Dai, David K C Cooper, Zhiming Cai, Lisha Mou
Xenotransplantation is an attractive solution to the problem of allograft shortage. However, transplants across discordant species barriers are subject to vigorous immunologic and pathobiologic hurdles, some of which might be overcome with the induction of immunologic tolerance. Several strategies have been designed to induce tolerance to a xenograft at both the central (including induction of mixed chimerism and thymic transplantation) and peripheral (including adoptive transfer of regulatory cells and blocking T cell costimulation) levels...
July 10, 2018: Archivum Immunologiae et Therapiae Experimentalis
Halina Cichoż-Lach, Ewelina Grywalska, Agata Michalak, Agnieszka Kowalik, Michał Mielnik, Jacek Roliński
To evaluate the role of Th17, Treg cells, activated T CD3+ and B CD19+ lymphocytes in primary biliary cholangitis (PBC) patients. 40 female patients with PBC and 20 healthy donors were enrolled in this study. The percentages and absolute counts of Th17, Treg, activated T CD3+ , B CD19+ , NK, NKT-like lymphocytes were measured by flow cytometry. Our research revealed significantly lower frequencies and absolute counts of CD4+ CD25+ FOXP3+ Treg cells (p < 0.0001), higher percentages and absolute counts of Th17 cells (IL-17A+ CD3+ CD4+ ; p < 0...
June 27, 2018: Archivum Immunologiae et Therapiae Experimentalis
Samra Sardar, Katrine Kanne, Åsa Andersson
The Mediator complex subunit 13-like (MED13L) protein is part of the multi-protein mediator complex and plays an important role in gene transcription. Polymorphisms in the MED13L gene have been linked to congenital heart anomalies and intellectual disabilities. Despite recent evidence of indirect links of MED13L to cytokine release and inflammation, impact of genetic variations in MED13L on immune cells remains unexplored. The B10.RIII and RIIIS/J mouse strains vary in susceptibility to induced experimental autoimmune disease models...
October 2018: Archivum Immunologiae et Therapiae Experimentalis
Kamila Wójcik-Cichy, Anna Piekarska, Elżbieta Jabłonowska
Damage of the mucosal barrier in HIV infection, microbial translocation, and immune activation can persist even in patients on successful antiretroviral therapy (ART) especially advanced late presenters. The aim of this study was to find factors that determine immune activation and bacterial translocation in HIV-infected advanced late presenters on suppressive ART. Forty-three late presenters (CD4 < 200 cells/µl prior to ART) on successful ART (more than 2 years of ART) with optimal and suboptimal CD4 recovery were enrolled into this study...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Zohreh Sadat Badieyan, Sayed Shahabuddin Hoseini
Cancer has been ranked as the second leading cause of death in the United States. To reduce cancer mortality, immunotherapy is gaining momentum among other therapeutic modalities, due to its impressive results in clinical trials. The genetically engineered T cells expressing chimeric antigen receptors (CARs) are emerging as a new approach in cancer immunotherapy, with the most successful outcomes in the refractory/relapse hematologic malignancies. However, the widespread clinical applications are limited by adverse effects some of which are life-threatening...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Kylie Su Mei Yong, Zhisheng Her, Qingfeng Chen
With an increasing human population, medical research is pushed to progress into an era of precision therapy. Humanized mice are at the very heart of this new forefront where it is acutely required to decipher human-specific disease pathogenesis and test an array of novel therapeutics. In this review, "humanized" mice are defined as immunodeficient mouse engrafted with functional human biological systems. Over the past decade, researchers have been conscientiously making improvements on the development of humanized mice as a model to closely recapitulate disease pathogenesis and drug mechanisms in humans...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Dorota Dąbrowska, Ewa Jabłońska, Marzena Garley, Jolanta Sawicka-Powierza, Karolina Nowak
Vascular diseases constitute a global health issue due to the increasing number of cases of patients with these diseases. The pathogenesis of the majority of these diseases, including atherosclerosis and thrombosis, is complex and not yet fully understood. One of the major causes for their occurrence can be immune disorders resulting in the development of a chronic inflammation within the vessels. In recent years, studies have placed emphasis on the role of neutrophils in the development of these diseases, i...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Agata O Zych, Malgorzata Bajor, Radoslaw Zagozdzon
The idea of using the effector immune cells to specifically fight cancer has recently evolved into an exciting concept of adoptive cell therapies. Indeed, genetically engineered T cells expressing on their surface recombinant, cancer-targeted receptors have been shown to induce promising response in oncological patients. However, in addition to exogenous expression of such receptors, there is also a need for disruption of certain genes in the immune cells to achieve more potent disease-targeted actions, to produce universal chimeric antigen receptor-based therapies or to study the signaling pathways in detail...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Monika Jedynak, Andrzej Siemiatkowski, Barbara Mroczko, Magdalena Groblewska, Robert Milewski, Maciej Szmitkowski
Early prognostic prediction of sepsis is essential in adjusting therapeutic protocols to prevent deterioration and reduce mortality. We compared the predictive value of the serum concentration of the soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) for 28-day mortality and for the development of severe sepsis or septic shock on the third day with the levels of interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin (PCT). The study was conducted on 85 patients with sepsis. sTREM-1, CRP, PCT and IL-6 concentrations were measured upon study inclusion (day 0) and on days 1, 2, 3 and 5...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Khaled Saad, Asmaa M Zahran, Khalid I Elsayh, Abobakr Abdelmoghny, Mohamed Diab Aboul-Khair
The studies of T-regulatory (Treg) cells in the pediatric allergic disorders, especially allergic rhinitis (AR), are very few and still far from being elucidated. The aim of this study is to assess the frequencies of CD4+ CD25+ Foxp3+ (CD4+ Tregs) and CD8+ CD25+high Foxp3+ (CD8+ Tregs) regulatory T lymphocytes in the peripheral blood of children with AR. In fresh whole blood of 60 children with AR and 40 healthy controls, the frequencies of CD4+ Tregs and CD8+ Tregs were examined by flow cytometry. The total IgE concentration in the serum was measured...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Danuta Nowicka, Ewelina Grywalska, Elżbieta Fitas, Michał Mielnik, Jacek Roliński
To analyze changes in the number and percentage of NK and NKT-like cells in relation to other immune cells as well as to examine associations between increased susceptibility to infections and NK and NKT-like status in patients with recurrent furunculosis (RF) and healthy controls. Thirty patients with RF and 20 healthy age- and sex-matched volunteers were recruited. Blood samples were examined. Lymphocyte count and cytometric analyses were conducted. For statistical analysis, the Student's t test, F test, and Brown-Forsythe test were used for comparison between groups of variables...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Krzysztof Orczyk, Elzbieta Smolewska
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood. Up to 50% of patients are resistant to standard therapy, which includes non-steroid anti-inflammatory drugs, corticosteroids, disease-modifying anti-rheumatic drugs and biologic therapies. Intra-articular injection of mesenchymal stem cells (MSCs) is proposed as a new approach to JIA treatment. MSCs can modulate inflammation via mechanisms of both adaptive and innate immune response. They are able to inhibit T and B cell proliferation, promote regulatory T cells, suppress the maturation of dendritic cells, stimulate macrophage differentiation into M2 phenotype and reduce effectiveness of natural killer cells...
August 2018: Archivum Immunologiae et Therapiae Experimentalis
Aziza Saidova, Ahuva Magder Hershkop, Marta Ponce, Thomas Eiwegger
Food allergy is the major reason for severe anaphylaxis in childhood and adolescence. Currently, effective and safe treatments for food allergy are unavailable. Allergen-specific CD4+ T cells have a pivotal role in causing and maintaining the allergic response to food allergens. The purpose of this review is to provide an overview on the role of allergen-specific T cells in food allergy during allergic sensitization, natural tolerance development and allergen immunotherapy. Allergen-specific T cells in the context of food allergy are predominantly of a Th2 type with slightly different surface marker expression patterns in different food allergies...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
Shenghou Liu, Hongwei Gao, Chunzheng Gao, Wenguang Liu, Deguo Xing
C-C motif chemokine ligand 2 (CCL2) is a small cytokine that functions in inflammation and cancer development. Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. As cancer-related inflammation is a cause of pain, we investigated whether Bindarit suppresses cancer-related inflammation and pain. We established a bone-cancer mouse model by inoculating cancer cells. After applying Bindarit, we preformed pain sensitivity tests and checked cancer development by X-ray...
June 2018: Archivum Immunologiae et Therapiae Experimentalis
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