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Laboratory Animals

Renata Snow, Christoph Mans, Helena Rylander
Chinchillas are popular as laboratory models and companion animals, and they can be affected by a variety of infectious and non-infectious neurological diseases. Little information is available on making a neurological diagnosis in this species, in part because the neurological examination has not been standardized in chinchillas and the expected physiological findings in healthy chinchillas have not been reported. In this study, a standardized neurological examination was performed on 30 clinically normal chinchillas...
December 2017: Laboratory Animals
Jennifer Freymann, Ping-Ping Tsai, Helge D Stelzer, Reinhard Mischke, Hansjoachim Hackbarth
The standard housing temperature in animal facilities is substantially below the lower critical temperature of mice. This does not only endanger animal welfare, it can also jeopardize scientific research as cold stress has a major impact on mouse physiology. There is some evidence that deep bedding, comparable to nesting material, can help mice to reduce heat loss. Whenever changes are applied to the cage environment, the potential impact on experimental results, including variation, needs to be assessed. An increased variation can result in a conflict between reduction and refinement, when more animals are needed for significance due to the housing design...
December 2017: Laboratory Animals
André Bleich, Rene H Tolba
No abstract text is available yet for this article.
December 2017: Laboratory Animals
Arieh Bomzon
No abstract text is available yet for this article.
December 2017: Laboratory Animals
Natalie Burden, John Kendrick, Lindsay Knight, Victoria McGregor, Helen Murphy, Malcolm Punler, Hans van Wijk
Bile duct cannulation (BDC) studies are usually carried out in the rat to support the absorption, distribution, metabolism and excretion profiling of novel agrochemicals and pharmaceuticals. The different aspects of these studies (e.g. surgical preparation, dosing and collection of bile) can be intricate and/or technically complex. The animals are often kept singly housed for the duration of the studies following surgical implantation of the cannulas. The generation of insufficient data to meet the study objectives, for example due to failure in cannula patency, can result in the need to repeat these studies...
October 2017: Laboratory Animals
Henri G M J Bertrand, Svenja Springer, Wesley Burnside, Charlotte Sandersen, Paul A Flecknell
Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery than isoflurane in a number of species, but no comparisons have been made in non-human primates. This study compared the recovery characteristics of isoflurane and sevoflurane in rhesus macaques undergoing experimental neurosurgery. Twelve primates (7 males and 5 females) were randomly allocated to the treatment groups...
October 2017: Laboratory Animals
Vijay Pal Singh
No abstract text is available yet for this article.
October 2017: Laboratory Animals
Yong Cheng, Lucas D Liepert, Justin Waller, W Matthew Leevy, Jeff S Schorey
Intratracheal injection is a traditional technique used in small animal studies of highly contagious airborne pathogens such as Mycobacterium tuberculosis. However, current techniques of intratracheal injection generally involve procedures that pose a risk of incident injury and infection for researchers, and may also cause collateral damage to experimental animals during the installation process. Here we describe an intratracheal injection method that was enabled by a three dimensional printing of a custom platform...
October 2017: Laboratory Animals
Elin Manell, Marianne Jensen-Waern, Patricia Hedenqvist
Pigs are commonly used in diabetes research due to their many physiological similarities to humans. They are especially useful in imaging procedures because of their large size. However, to achieve imaging procedures the pig must lie completely still, and thus needs to be anaesthetized. Most anaesthetic drugs used in laboratory animals affect carbohydrate metabolism by the inhibition of insulin release. The aim of this pilot study was primarily to develop an anaesthetic protocol for pigs that did not have an effect on blood glucose levels throughout the 3 h of anaesthesia; and secondly, to evaluate the most promising protocol in combination with an oral glucose tolerance test (OGTT)...
October 2017: Laboratory Animals
Julie L Eiseman, Michael Sciullo, Hong Wang, Jan H Beumer, Charles C Horn
Several cancer chemotherapies cause nausea and vomiting, which can be dose-limiting. Musk shrews are used as preclinical models for chemotherapy-induced emesis and for antiemetic effectiveness. Unlike rats and mice, shrews possess a vomiting reflex and demonstrate an emetic profile similar to humans, including acute and delayed phases. As with most animals, dosing of shrews is based on body weight, while translation of such doses to clinically equivalent exposure requires doses based on body surface area. In the current study body surface area in musk shrews was directly assessed to determine the Meeh constant (Km) conversion factor (female = 9...
October 2017: Laboratory Animals
Aurelie Anic Thomas, Johann Detilleux, Charlotte Friederike Sandersen, Paul Andrew Flecknell
The intrathecal (IT) route of administration represents a means to reduce the dose of morphine administered for analgesia, potentially minimizing interactions between opioid effects and experimental outcomes. Perceived technical difficulty, and previously described invasive methods, may limit its use. This report describes a minimally invasive technique for IT administration of morphine by direct transcutaneous lumbosacral puncture in rats; and assesses antinociceptive properties of morphine in anaesthetized rats...
October 2017: Laboratory Animals
David Tibor Lauber, András Fülöp, Tibor Kovács, Krisztián Szigeti, Domokos Máthé, Attila Szijártó
In recent decades, imaging devices have become indispensable tools in the basic sciences, in preclinical research and in modern drug development. The rapidly evolving high-resolution in vivo imaging technologies provide a unique opportunity for studying biological processes of living organisms in real time on a molecular level. State of the art small-animal imaging modalities provide non-invasive images rich in quantitative anatomical and functional information, which renders longitudinal studies possible allowing precise monitoring of disease progression and response to therapy in models of different diseases...
October 2017: Laboratory Animals
Paul K J D de Jonge, Marije Sloff, Heinz P Janke, Barbara B M Kortmann, Robert P E de Gier, Paul J Geutjes, Egbert Oosterwijk, Wout F J Feitz
It is common to test medical devices in large animal studies that are or could also be used in humans. In this short report we describe the use of a ureteral J-stent for the evaluation of biodegradable tubular constructs for tissue reconstruction, and the regeneration of ureters in Saanen goats. Similarly to a previous study in pigs, the ureteral J-stent was blindly inserted until some resistance was met. During evaluation of the goats after three months, perforation of the renal cortex by the stent was observed in four out of seven animals...
October 2017: Laboratory Animals
Nuno Franco
No abstract text is available yet for this article.
August 2017: Laboratory Animals
Anton M Pluschke, Gregory S Simmons, Helen L Keates, Ranald D A Cameron, Dagong Zhang, John D Wright, Barbara A Williams
Jugular catheterization is a common procedure used under experimental conditions. However, there is considerable variation in the reported techniques, particularly for grower pigs (>40 kg and <60 kg) when larger volumes of blood per sample (>10 mL) are required. This paper provides a complete methodology including the use of current equipment and anaesthetic regimen for grower pigs. This surgical jugular catheterization method was carried out in 30 large white grower pigs. Firstly, the pigs were habituated to human handling for at least two weeks prior to surgery...
August 2017: Laboratory Animals
Jose Orellana, Eleanor Weir
No abstract text is available yet for this article.
June 2017: Laboratory Animals
Paulin Jirkof, Beat M Riederer, Arieh Bomzon
No abstract text is available yet for this article.
June 2017: Laboratory Animals
Grupo de Trabajo de la Secal
No abstract text is available yet for this article.
June 2017: Laboratory Animals
Beat M Riederer, Arieh Bomzon, Paulin Jirkof
Good communication is important for the dissemination of research results. Here, we summarize the advice that was given to authors at the LA seminar on scientific writing at the FELASA Congress 2016 in Brussels, Belgium on 13-16 June 2016, with the aim of improving the quality of submitted papers and of avoiding common mistakes in scientific reports. See .
June 2017: Laboratory Animals
Ekaterina A Litvinova, Elena N Kozhevnikova, Ksenia M Achasova, Galina V Kontsevaya, Mikhail P Moshkin
Infections with Helicobacter spp. are known to have serious effects on rodent health, especially in immunocompromised animals. In this study three approaches were used to eradicate Helicobacter spp. infection in mice with a deficiency in intestinal proteoglycan (mucin2), namely triple oral antibiotic therapy (amoxicillin, clarithromycin and metronidazole), cross-fostering of neonatal pups by surrogate mothers negative for Helicobacter spp., and in vitro fertilization (IVF) with embryo transfer into Helicobacter-free mothers...
June 2017: Laboratory Animals
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