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Laboratory Animals

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https://www.readbyqxmd.com/read/27932686/computed-tomography-based-survey-of-the-vascular-anatomy-of-the-juvenile-g%C3%A3-ttingen-minipig
#1
J Siefert, K H Hillebrandt, M Kluge, D Geisel, P Podrabsky, T Denecke, M Nösser, J Gassner, A Reutzel-Selke, B Strücker, M H Morgul, S Guel-Klein, J K Unger, A Reske, J Pratschke, I M Sauer, N Raschzok
Over the past 50 years, image-guided procedures have been established for a wide range of applications. The development and clinical translation of new treatment regimens necessitate the availability of suitable animal models. The juvenile Göttingen minipig presents a favourable profile as a model for human infants. However, no information can be found regarding the vascular system of juvenile minipigs in the literature. Such information is imperative for planning the accessibility of target structures by catheterization...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27932685/longitudinal-micro-computed-tomography-monitoring-of-progressive-liver-regeneration-in-a-mouse-model-of-partial-hepatectomy
#2
Olga M Will, Timo Damm, Graeme M Campbell, Witigo von Schönfells, Yahya Açil, Marcus Will, Athena Chalaris-Rissmann, Mustafa Ayna, Claudia Drucker, Claus-Christian Glüer
The partial hepatectomy (PH) model is widely used to study liver regeneration. Currently, the extent of regeneration is analyzed by measuring the weight of the liver post-mortem or by magnetic resonance imaging. In this study we aimed to determine whether liver volume gain can be accurately measured using micro-computed tomography (microCT). Approximately 42% of the liver was removed by ligation in C57BL/6 N mice. Mice were divided into two study groups. In group 1 conventional characterization of liver hyperplasia was performed by weighing the liver post-mortem...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27932684/standardizing-the-microbiota-of-fish-used-in-research
#3
REVIEW
I N Vatsos
Little attention has been paid to the effects of fish microbiotas on the reproducibility and comparability of fish studies so far. Extrinsic and intrinsic factors, such as water quality, environmental microbial populations, diet, host genetic profile, gender, age and stress status, affect fish microbiotas and create significant inter- and intra-species variations. Fish microbiotas play critical roles in many key aspects of host physiology, such as protection against pathogens, digestion and development of the digestive tract and the local immune system...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27932683/survival-of-bacteria-of-laboratory-animal-origin-on-cage-bedding-and-inactivation-by-hydrogen-peroxide-vapour
#4
Laurentiu Benga, W Peter M Benten, Eva Engelhardt, Christina Gougoula, Roland Schulze-Röbbecke, Martin Sager
This study aims to determine the ability of laboratory animal bacteria to resist desiccation and inactivation by hydrogen peroxide vapour (HPV) on paper bedding pieces. Bedding pieces were saturated with bacterial suspensions in water or 2% (w/v) bovine serum albumin (BSA) in water, and held in a mouse facility. Viable counts showed variable survival rates over time for the bacterial species used ([Pasteurella] pneumotropica, Muribacter muris, Pseudomonas aeruginosa, Acinetobacter redioresistens, Escherichia coli, Klebsiella oxytoca, Bordetella bronchiseptica, Bordetella hinzii, Enterococcus faecalis, β-haemolytic Streptococcus spp...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27932682/preliminary-assessment-of-midazolam-fentanyl-and-fluanisone-combination-for-the-sedation-of-rhesus-macaques-macaca-mulatta
#5
Henri G M J Bertrand, Charlotte F Sandersen, Paul A Flecknell
This study was undertaken to assess the suitability of fentanyl/fluanisone ('Hypnorm', VetaPharma; 0.315 mg/mL of fentanyl citrate and 10 mg/mL of fluanisone) alone or combined with midazolam in rhesus macaques. Fifteen rhesus macaques requiring sedation for veterinary procedures received an intramuscular (IM) dose range of Hypnorm from 0.01 mL/kg to 0.3 mL/kg either alone or combined with 0.5 mg/kg of midazolam. To reverse the sedation, flumazenil in combination with either naloxone, buprenorphine or butorphanol was administered intravenously (IV) or IM...
December 8, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27888262/search-for-an-animal-model-to-investigate-selective-pulmonary-vasodilation
#6
Bodil Petersen, Thilo Busch, Katharina Noreikat, Lorenz Homeister, Ralf Regenthal, Udo X Kaisers
Pulmonary arterial hypertension is a life-threatening disease with a poor prognosis. Oral treatment with vasodilators is often limited by systemic hypotension. Inhalation of vasodilators offers the opportunity for selective pulmonary vasodilation. Testing selective pulmonary vasodilation by inhaled nitric oxide or alternative substances in animal models requires an increased pulmonary vascular tone. The aim of this study was to identify animal models that are suitable for investigating selective pulmonary vasodilation...
November 25, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27838637/you-and-your-research-report-implementing-the-arrive-reporting-guideline
#7
EDITORIAL
Arieh Bomzon
No abstract text is available yet for this article.
November 11, 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909199/iniciativa-espa%C3%A3-ola-para-mejorar-la-transparencia-en-el-uso-de-animales-de-experimentaci%C3%A3-n
#8
Javier Guillén
No abstract text is available yet for this article.
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909198/anaesthesia-and-analgesia-in-laboratory-adult-zebrafish-a-question-of-refinement
#9
Tânia Martins, Ana M Valentim, Nuno Pereira, Luis M Antunes
Anaesthesia is used daily in fish experimental procedures; however, the use of an inadequate anaesthetic protocol can compromise not only the animal's welfare but also the reliability of results. The use of zebrafish (Danio rerio) in biomedical research has increased in the last decades, highlighting the importance of appropriate anaesthetic regimens for this species. This article reviews the main anaesthetic agents and protocols used in laboratory adult zebrafish, and some of the analgesic methods to be used in this species that still need more research...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909197/severity-assessment-in-rabbits-after-partial-hepatectomy-part-ii
#10
N Drude, K Pawlowsky, H Tanaka, K Fukushima, B Kögel, R H Tolba
Although the recognition of pain, distress and discomfort has already been described in 1985 by Morton and Griffiths there is still very little known about the establishment of score sheets especially, regarding post-surgical pain and severity assessment for laboratory animals such as rabbits. In this paper we describe the estimation of severity and recovery status of 36 female New Zealand White rabbits (NZW) in a standardized liver resection model using two different adhesive treatments and one control group...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909196/recommendation-for-severity-assessment-following-liver-resection-and-liver-transplantation-in-rats-part-i
#11
S Kanzler, A Rix, Z Czigany, H Tanaka, K Fukushima, B Kögel, K Pawlowsky, R H Tolba
Score sheets were first introduced 30 years ago to assess pain, distress and suffering in animals. To date, however, there is still no general agreement on their use in research practice, and only a few publications can be found on this topic. In the present work, we demonstrate the use of a special score sheet for severity assessment in the first three postoperative days in two showcased studies performed on Wistar and Lewis rats undergoing liver resection or orthotopic liver transplantation, respectively...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909195/morbidity-scoring-after-abdominal-surgery
#12
Rolf Graf, Paolo Cinelli, Margarete Arras
Postoperative monitoring of pain and distress in small rodents is not standardized, and widely accepted score sheets are not available. Here we describe a score sheet used in abdominal surgery of rodents, with particular reference to procedures involving the liver.
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909194/severity-assessment-and-scoring-for-neurosurgical-models-in-rodents
#13
Sarah Pinkernell, Katrin Becker, Ute Lindauer
The most important acute neurological diseases seen at neurosurgery departments are traumatic brain injuries (TBI) and subarachnoid hemorrhages (SAH). In both diseases the pathophysiological sequela are complex and have not been fully understood up to now, and rodent models using rats and mice are most suitable for the investigation of the pathophysiological details. In both models, surgery is performed under anesthesia, followed by assessment of their functional outcome and behavioral testing before brain tissue analysis after euthanasia...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909193/osteotomy-models-the-current-status-on-pain-scoring-and-management-in-small-rodents
#14
Annemarie Lang, Anja Schulz, Agnes Ellinghaus, Katharina Schmidt-Bleek
Fracture healing is a complex regeneration process which produces new bone tissue without scar formation. However, fracture healing disorders occur in approximately 10% of human patients and cause severe pain and reduced quality of life. Recently, the development of more standardized, sophisticated and commercially available osteosynthesis techniques reflecting clinical approaches has increased the use of small rodents such as rats and mice in bone healing research dramatically. Nevertheless, there is no standard for pain assessment, especially in these species, and consequently limited information regarding the welfare aspects of osteotomy models...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909192/the-more-the-merrier-scoring-statistics-and-animal-welfare-in-experimental-autoimmune-encephalomyelitis
#15
Pushpalatha Palle, Filipa M Ferreira, Axel Methner, Thorsten Buch
Experimental autoimmune encephalomyelitis (EAE) is a frequently used animal model for the investigation of autoimmune processes in the central nervous system. As such, EAE is useful for modelling certain aspects of multiple sclerosis, a human autoimmune disease that leads to demyelination and axonal destruction. It is an important tool for investigating pathobiology, identifying drug targets and testing drug candidates. Even though EAE is routinely used in many laboratories and is often part of the routine assessment of knockouts and transgenes, scoring of the disease course has not become standardized in the community, with at least 83 published scoring variants...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909191/analgesia-in-clinically-relevant-rodent-models-of-sepsis
#16
Victor Jeger, Till Hauffe, Flora Nicholls-Vuille, Dominique Bettex, Alain Rudiger
Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in this respect. In this review, we describe different concepts of analgesia in rodent models of sepsis focusing on opioid agonists as well as non-opioid analgesics. Advantages and pitfalls in study design and side-effects are discussed...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909190/what-the-literature-tells-us-about-score-sheet-design
#17
Philippe Bugnon, Maike Heimann, Michaela Thallmair
Score sheets are an essential tool of animal welfare. They allow transparent assessments to be made of animal health and behavior during animal experiments and they define interventions when deviations from normal status are detected. As such, score sheets help to refine animal experiments as part of the 3R (replacement, reduction and refinement) concept. This mini review aims at summarizing the scarce literature available on score sheet design.
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909189/score-sheets-and-analgesia
#18
EDITORIAL
Huw Golledge, Paulin Jirkof
No abstract text is available yet for this article.
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27909188/thanks-to-reviewers
#19
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27672130/recomendaciones-para-controles-microbiol%C3%A3-gicos-ambientales-y-de-agua-en-un-animalario
#20
Luis Parra
No abstract text is available yet for this article.
October 2016: Laboratory Animals
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