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Laboratory Animals

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https://www.readbyqxmd.com/read/29779469/professor-jean-ren%C3%A3-maisin
#1
Patri Vergara, Ouajdi Souilem, Cynthia Pekow, Guy De Vroey
No abstract text is available yet for this article.
June 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29779468/the-next-popular-felasa-congress-10-13-june-2019-prague
#2
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29552979/felasa-s-40th-anniversary
#3
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29552978/report-from-the-2017-annual-sgv-meeting
#4
Mark Deurinck, Stefanie Schindler, Philippe Bugnon, Isabelle Desbaillets, Gisèle Ferrand, Marcel Gyger, Maike Heimann, Stefanie Wyss, Stephan Zeiter
No abstract text is available yet for this article.
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29385896/dr-stian-erichsen
#5
Patrocinio Vergara Esteras, Adrian Smith, Cynthia Pekow
No abstract text is available yet for this article.
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29058999/feasibility-of-transthoracic-echocardiographic-imaging-in-non-sedated-ovine-subjects-using-a-commercial-restraint-device
#6
Michelle E Colpitts, Rachel C Phillion, Marcin Malinowski, Rhonda A Coleman, Lou A Mitchell, Angela B Malone, Lenora L Eberhart, Robert A Sanders, David E Langholz
Transthoracic echocardiography (TTE) is a valuable non-invasive imaging research technique. In ovine models of cardiac disease, restraint for TTE often involves sedation even with currently available restraint equipment; our goal was to determine the feasibility of using a commercial restraint device, commonly known as the sheep chair, in minimizing animal stress and the need for sedation while achieving a complete TTE examination. A total of 10 healthy adult Dorset sheep were restrained in a sheep chair for TTE and observed for signs of stress...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29058998/liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms-and-dried-blood-spot-sampling-applied-to-pharmacokinetics-studies-in-animals-correlation-of-classic-and-block-design
#7
Matías N Baldo, Emmanuel Angeli, Natalia C Gareis, Gabriel A Hunzicker, Marcelo C Murguía, Hugo H Ortega, Gustavo J Hein
A relative bioavailability study (RBA) of two phenytoin (PHT) formulations was conducted in rabbits, in order to compare the results obtained from different matrices (plasma and blood from dried blood spot (DBS) sampling) and different experimental designs (classic and block). The method was developed by liquid chromatography tandem-mass spectrometry (LC-MS/MS) in plasma and blood samples. The different sample preparation techniques, plasma protein precipitation and DBS, were validated according to international requirements...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28771074/prepare-guidelines-for-planning-animal-research-and-testing
#8
Adrian J Smith, R Eddie Clutton, Elliot Lilley, Kristine E Aa Hansen, Trond Brattelid
There is widespread concern about the quality, reproducibility and translatability of studies involving research animals. Although there are a number of reporting guidelines available, there is very little overarching guidance on how to plan animal experiments, despite the fact that this is the logical place to start ensuring quality. In this paper we present the PREPARE guidelines: Planning Research and Experimental Procedures on Animals: Recommendations for Excellence. PREPARE covers the three broad areas which determine the quality of the preparation for animal studies: formulation, dialogue between scientists and the animal facility, and quality control of the various components in the study...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28758534/local-anaesthetic-refinement-of-pentobarbital-euthanasia-reduces-abdominal-writhing-without-affecting-immunohistochemical-endpoints-in-rats
#9
Shaun Y-S Khoo, Belinda P P Lay, Josephine Joya, Gavan P McNally
Sodium pentobarbital is a commonly used agent for euthanizing laboratory rats, however its high pH can cause abdominal discomfort after intraperitoneal injection. Previous studies suggest that the addition of a local anaesthetic may alleviate this discomfort, but the practice has not been widely adopted. We examined the effect of combining lidocaine with pentobarbital on abdominal writhing, defecation, ultrasonic vocalizations, the rat grimace scale and immunohistochemical staining for c-Fos in the nucleus accumbens and basolateral amygdala of the brain...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28691600/simultaneous-detection-of-multiple-pathogens-by-multiplex-pcr-coupled-with-dna-biochip-hybridization
#10
Hsiang-Yun Tung, Wei-Chen Chen, Bor-Rung Ou, Jan-Ying Yeh, Yeong-Hsiang Cheng, Ping-Hua Tsng, Ming-Hua Hsu, Ming-Shiun Tsai, Yu-Chuan Liang
Traditional serological enzyme-linked immunosorbent assay (ELISA) is routinely used to monitor pathogens during quarantine in most animal facilities to prevent possible infection. However, the ELISA platform is a single-target assay, and screening all targeted pathogens is time-consuming and laborious. In this study, to increase sensitivity and to reduce diagnosis time for high-throughput processes, multiplex PCR and DNA biochip techniques were combined to develop a multi-pathogen diagnostic method for use instead of routine ELISA...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28691599/sheep-model-of-haemodialysis-treatment
#11
Jolanta Bujok, Tomasz Walski, Albert Czerski, Katarzyna Gałecka, Karolina Grzeszczuk-Kuć, Wojciech Zawadzki, Wojciech Witkiewicz, Małgorzata Komorowska
More than two million patients received haemodialysis (HD) in 2013. Many methods for improving dialysis therapy outcomes have been tested. Nevertheless, patients continue to experience high morbidity and mortality rates. We aimed to develop an animal model of HD treatment to study methods that would prevent the adverse effects of renal replacement therapy. The study was conducted using six male Merino sheep. The animals underwent a two-step bilateral nephrectomy, and a permanent dual-lumen catheter was inserted into the jugular vein...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28679339/characteristics-of-a-pseudomonas-aeruginosa-induced-porcine-sepsis-model-for-multi-organ-metabolic-flux-measurements
#12
Gabriella A M Ten Have, Renske C I Deutz, Mariëlle P K J Engelen, Robert R Wolfe, Nicolaas E P Deutz
Survival of sepsis is related to loss of muscle mass. Therefore, it is imperative to further define and understand the basic alterations in nutrient metabolism in order to improve targeted sepsis nutritional therapies. We developed and evaluated a controlled hyperdynamic severe sepsis pig model that can be used for in vivo multi-organ metabolic studies in a conscious state. In this catheterized pig model, bacteremia was induced intravenously with 109 CFU/h Pseudomonas aeruginosa (PA) in 13 pigs for 18 h. Both the PA and control (nine) animals received fluid resuscitation and were continuously monitored...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28599579/forced-air-pre-warming-prevents-peri-anaesthetic-hypothermia-and-shortens-recovery-in-adult-rats
#13
C J Schuster, D S J Pang
General anaesthesia disrupts thermoregulation in mammals, which can cause hypothermia. Decreases in core body temperature of 1℃ cause significant postoperative complications in humans, and peri-anaesthetic hypothermia in mice increases data variability, which can potentially increase animal use. In rats, the impact of different temperature management strategies on the incidence and severity of hypothermia, and the accuracy of different temperature measurement methods, is unknown. Eighteen adult male and female SD rats were block-randomized to one of three treatment groups: no-warming (NW), limited-warming (LW, heat pad during anaesthesia), and pre-warming (PW, warm air exposure before anaesthesia, followed by heat pad)...
April 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29388891/reorganization-of-the-journal-s-editorial-board-to-improve-the-journal-s-productivity-and-efficiency
#14
Beat M Riederer, Paulin Jirkof, Arieh Bomzon
No abstract text is available yet for this article.
February 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29359995/classification-and-reporting-of-severity-experienced-by-animals-used-in-scientific-procedures-felasa-eclam-eslav-working-group-report
#15
David Smith, David Anderson, Anne-Dominique Degryse, Carla Bol, Ana Criado, Alessia Ferrara, Nuno Henrique Franco, Istvan Gyertyan, Jose M Orellana, Grete Ostergaard, Orsolya Varga, Hanna-Marja Voipio
Directive 2010/63/EU introduced requirements for the classification of the severity of procedures to be applied during the project authorisation process to use animals in scientific procedures and also to report actual severity experienced by each animal used in such procedures. These requirements offer opportunities during the design, conduct and reporting of procedures to consider the adverse effects of procedures and how these can be reduced to minimize the welfare consequences for the animals. Better recording and reporting of adverse effects should also help in highlighting priorities for refinement of future similar procedures and benchmarking good practice...
February 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29207903/professor-klaus-g%C3%A3-rtner-1927-2017
#16
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28992802/preputial-diverticulum-dilation-in-a-goettingen-minipig
#17
Nora Denk, Claudia Senn, Bjoern Jacobsen, Tobias Schnitzer
Preputial dilation is an infrequently reported condition in pigs. The pathophysiology and etiology is unclear. Causes for diverticulum dilation are proposed to be chronic preputial diverticulitis with subsequent fibrosis of the preputial cavity, phimosis of the preputial orifice or the preputial diverticulum, but the large majority of cases are reportedly idiopathic in nature. Surgical interventions include ablative procedures, but many cases are not treated because of an assumed lack of clinical relevance in pigs not used for breeding...
February 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28708034/ultrasound-guided-percutaneous-common-carotid-artery-access-in-piglets-for-intracoronary-stem-cell-infusion
#18
Jason H Anderson, Nathaniel W Taggart, Sarah L Edgerton, Susana Cantero Peral, Kimberly A Holst, Frank Cetta
In pigs, the deep location of the common carotid artery and overlying sternomastoideus muscle in the neck has led to the recommendation for a surgical cutdown for common carotid access, as opposed to minimally invasive techniques for vascular access. We sought to determine if direct percutaneous common carotid artery access in piglets is attainable. Seventeen piglets were anesthetized and intubated. Under two-dimensional and color flow Doppler ultrasound guidance, a 21 gauge needle was utilized to access the right common carotid artery...
February 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28696159/quality-of-reporting-of-otorhinolaryngology-articles-using-animal-models-with-the-arrive-statement
#19
Aren Bezdjian, Sjaak F L Klis, Jeroen P M Peters, Wilko Grolman, Inge Stegeman
Research involving animal models is crucial for the advancement of science, provided that experiments are designed, performed, interpreted, and reported well. In order to investigate the quality of reporting of articles in otorhinolaryngology research using animal models, a PubMed database search was conducted to retrieve eligible articles. The checklist of the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines was used to assess the quality of reporting of articles published in ear, nose and throat (ENT) and multidisciplinary journals...
February 2018: Laboratory Animals
https://www.readbyqxmd.com/read/28595508/sedative-and-cardiorespiratory-effects-of-detomidine-constant-rate-infusion-in-sheep
#20
Rauane Sousa de Moura, Isabela Plazza Bittar, Luiz Henrique da Silva, Ana Carolina Vasquez Villela, Marcelo Borges Dos Santos Júnior, Naida Cristina Borges, Leandro Guimarães Franco
The use of sheep in experiments is widespread and is increasing worldwide, and so is the need to develop species-specific anaesthetic techniques to ensure animal safety. Previous studies have mentioned several protocols involving the administration of alpha-2 adrenergic agonists in sheep; however, assessment of the efficacy and safety of these infusion techniques is still relatively new. Thus, the aim of the present study is to assess the effectiveness of detomidine constant rate infusion (CRI) in sheep by measuring the cardiovascular and respiratory parameters, blood gas variables and sedation scores...
February 2018: Laboratory Animals
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