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Laboratory Animals

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https://www.readbyqxmd.com/read/28332934/vii-jornada-cient%C3%A3-fica-secal-7th-secal-scientific-meeting
#1
David Muñoz Valverde, Clara Muñoz Mediavilla
No abstract text is available yet for this article.
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28332933/alternative-methods-for-killing-laboratory-animals-summary-of-a-published-advisory-report-by-the-netherlands-national-committee-for-the-protection-of-animals-used-for-scientific-purposes-and-for-education-ncad
#2
https://www.readbyqxmd.com/read/28332932/humane-endpoints-website-huge-success-in-spain-and-the-rest-of-the-world
#3
Saskia Kliphuis
No abstract text is available yet for this article.
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27838637/you-and-your-research-report-implementing-the-arrive-reporting-guideline
#4
Arieh Bomzon
No abstract text is available yet for this article.
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27609810/non-invasive-detection-and-successful-treatment-of-a-helicobacter-pylori-infection-in-a-captive-rhesus-macaque
#5
Antje Semrau, Susanne Gerold, Julia-Stefanie Frick, Franz Iglauer
Gastritis is a commonly diagnosed condition in non-human primates used in biomedical research. As in humans, Helicobacter pylori infection may cause gastritis. The following report presents a method of non-invasive detection and a successful treatment protocol for this common pathogen.
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27357187/new-and-safe-experimental-model-of-radiation-induced-neurovascular-histological-changes-for-microsurgical-research
#6
Sergi Barrera-Ochoa, Irene Gallardo-Calero, Andrea Sallent, Alba López-Fernández, Ramona Vergés, Jordi Giralt, Marius Aguirre-Canyadell, Roberto Velez
The aim is to create a new and safe experimental model of radiation-induced neurovascular histological changes with reduced morbidity and mortality for use with experimental microsurgical techniques. Seventy-two Sprague-Dawley rats (250-300 g) were divided as follows: Group I: control group, 24 rats clinically evaluated during six weeks; Group II: evaluation of acute side-effects (two-week follow-up period), 24 irradiated (20 Gy) rats; and Group III: evaluation of subacute side-effects (six-week follow-up period), 24 irradiated (20 Gy) rats...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27307423/does-age-matter-the-impact-of-rodent-age-on-study-outcomes
#7
Samuel J Jackson, Nick Andrews, Doug Ball, Ilaria Bellantuono, James Gray, Lamia Hachoumi, Alan Holmes, Judy Latcham, Anja Petrie, Paul Potter, Andrew Rice, Alison Ritchie, Michelle Stewart, Carol Strepka, Mark Yeoman, Kathryn Chapman
Rodent models produce data which underpin biomedical research and non-clinical drug trials, but translation from rodents into successful clinical outcomes is often lacking. There is a growing body of evidence showing that improving experimental design is key to improving the predictive nature of rodent studies and reducing the number of animals used in research. Age, one important factor in experimental design, is often poorly reported and can be overlooked. The authors conducted a survey to assess the age used for a range of models, and the reasoning for age choice...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27255277/sorting-it-out-bedding-particle-size-and-nesting-material-processing-method-affect-nest-complexity
#8
Amy Robinson-Junker, Amelia Morin, Kathleen Pritchett-Corning, Brianna N Gaskill
As part of routine husbandry, an increasing number of laboratory mice receive nesting material in addition to standard bedding material in their cages. Nesting material improves health outcomes and physiological performance in mice that receive it. Providing usable nesting material uniformly and efficiently to various strains of mice remains a challenge. The aim of this study was to determine how bedding particle size, method of nesting material delivery, and processing of the nesting material before delivery affected nest building in mice of strong (BALB/cAnNCrl) and weak (C3H/HeNCrl) gathering abilities...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27252027/ketamine-alone-or-combined-with-midazolam-or-dexmedetomidine-does-not-affect-anxiety-like-behaviours-and-memory-in-adult-wistar-rats
#9
Ana Magalhães, Ana Valentim, Carlos Venâncio, Mariana Pereira, Pedro Melo, Teresa Summavielle, Luis Antunes
Ketamine administration has been associated with controversial behavioural impairments and psychotic episodes. Even though ketamine alone and in combination with midazolam or dexmedetomidine are frequently used in laboratory animals, the side-effects of such protocols are not well known. Therefore, our aim was to evaluate the effects of ketamine alone and in combination with midazolam or dexmedetomidine on emotional reactivity, as well as the effects on learning and memory in adult rats at least 48 h after anaesthesia...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27236141/embryonated-pigeon-eggs-as-a-model-to-investigate-neospora-caninum-infection
#10
Somayeh Bahrami, Annahita Rezaie, Zahra Boroomand, Mehdi Namavari, Sepideh Ghavami
It has been shown that embryonated chicken eggs can be used as animal models for experimental infections. The aim of the present study was to investigate pigeon embryonated eggs as animal models for experimental neosporosis. An infection with Neospora caninum Nc1 isolate was conducted in chicken and pigeon embryonated eggs to evaluate LD50. After calculation of LD50, 2LD50 of tachyzoites were injected into the eggs. Macroscopic changes of each embryo were observed, and immunohistochemistry (IHC) and molecular methods were used to investigate the parasitic distribution in the tissues...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27230409/animal-facility-videoendoscopic-intubation-station-tips-and-tricks-from-mice-to-rabbits
#11
Alice Miranda, José M Pêgo, Jorge Correia-Pinto
Endotracheal intubation of laboratory animals is a common procedure shared by several research fields for different purposes, such as mechanical ventilation of anaesthetized animals, instillation of cytotoxic nanoparticles, infectious agents or tumour cells for induction of disease models, and even for diagnostic and therapeutic purposes. These different research purposes, achieved in different animal models, require technical expertise and equipment that suits every research need from animal facilities. In this short report we propose a videoendoscopic intubation station that could be shared among the most common laboratory animals, namely the mouse, rat, guinea pig and rabbit, from neonates to adult animals...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27166392/a-highly-efficient-strategy-to-determine-genotypes-of-genetically-engineered-mice-using-genomic-dna-purified-from-hair-roots
#12
Víctor Otaño-Rivera, Amma Boakye, Nadja Grobe, Mohammed M Almutairi, Shams Kursan, Lesan K Mattis, Hayo Castrop, Susan B Gurley, Khalid M Elased, Gregory P Boivin, Mauricio Di Fulvio
Genotyping of genetically-engineered mice is necessary for the effective design of breeding strategies and identification of mutant mice. This process relies on the identification of DNA markers introduced into genomic sequences of mice, a task usually performed using the polymerase chain reaction (PCR). Clearly, the limiting step in genotyping is isolating pure genomic DNA. Isolation of mouse DNA for genotyping typically involves painful procedures such as tail snip, digit removal, or ear punch. Although the harvesting of hair has previously been proposed as a source of genomic DNA, there has been a perceived complication and reluctance to use this non-painful technique because of low DNA yields and fear of contamination...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27118731/the-use-of-ultrasound-to-assess-fetal-growth-in-a-guinea-pig-model-of-fetal-growth-restriction
#13
A M Swanson, V Mehta, K Ofir, M Rowe, C Rossi, Y Ginsberg, H Griffin, H Barker, T White, M Boyd, A L David
Fetal growth restriction (FGR) is a common and potentially severe pregnancy complication. Currently there is no treatment available. The guinea pig is an attractive model of human pregnancy as placentation is morphologically very similar between the species. Nutrient restriction of the dam creates growth-restricted fetuses while leaving an intact uteroplacental circulation, vital for evaluating novel therapies for FGR. Growth-restricted fetuses were generated by feeding Dunkin Hartley guinea pig dams 70% of ad libitum intake from four weeks before and throughout pregnancy...
April 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28145819/xiv-congreso-nacional-de-secal-las-palmas-de-gran-canaria-islas-canarias-espa%C3%A3-a-junio-2017
#14
José Luis Martín-Barrasa
No abstract text is available yet for this article.
February 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27368710/echocardiographic-effects-of-dexmedetomidine-ketamine-in-chinchillas-chinchilla-lanigera
#15
Grayson A Doss, Christoph Mans, Rebecca L Stepien
Alpha2-agonist anesthetic combinations are often used in rodent anesthesia but no information about their effects on cardiac function in chinchillas exists. The purpose of this study was to utilize echocardiography to evaluate the cardiovascular effects of dexmedetomidine-ketamine anesthesia in chinchillas. Echocardiographic examinations were performed in eight adult chinchillas under manual restraint and following dexmedetomidine (0.015 mg/kg) and ketamine (4 mg/kg) administration. Dexmedetomidine-ketamine anesthesia resulted in a significantly decreased heart rate, fractional shortening, cardiac output, and flow velocity across the aortic and pulmonic valves, and significantly increased left ventricular internal diameter in systole...
February 2017: Laboratory Animals
https://www.readbyqxmd.com/read/27098142/refinement-of-a-model-of-repeated-cerebrospinal-fluid-collection-in-conscious-rats
#16
Eva Maria Amen, Muriel Brecheisen, Lisa Sach-Peltason, Alessandra Bergadano
The cannulation of the cisterna magna in rats for in vivo sampling of cerebrospinal fluid serves as a valuable model for studying the delivery of new drugs into the central nervous system or disease models. It offers the advantages of repeated sampling without anesthesia-induced bias and using animals as their own controls. An established model was retrospectively reviewed for the outcomes and it was hypothesized that by refining the method, i.e. by (1) implementing pathophysiological-based anesthesia and analgesia, (2) using state-of-the-art peri-operative monitoring and supportive care, (3) increasing stability of the cement-cannula assembly, and (4) selecting a more adaptable animal strain, the outcome in using the model - quantified by peri-operative mortality, survival time and stability of the implant - could be improved and could enhance animal welfare...
February 2017: Laboratory Animals
https://www.readbyqxmd.com/read/26994106/a-less-invasive-method-for-orthotopic-injection-of-breast-cancer-cells-into-the-mouse-mammary-gland
#17
Luz E Tavera-Mendoza, Myles Brown
Breast cancer is the most common type of cancer diagnosed in women, and the second most common cause of cancer-related deaths in women in North America. The use of laboratory mice in research is an essential tool for the study of breast cancer biology and for pre-clinical therapeutic development. While subcutaneous flank injections of cancer cells are widely used for studying breast cancer biology and for exploring novel therapies, orthotopic xenografting of tumors into the mouse mammary gland allow for the study of breast cancers in a biologically relevant microenvironment...
February 2017: Laboratory Animals
https://www.readbyqxmd.com/read/26985009/phenoworld-addressing-animal-welfare-in-a-new-paradigm-to-house-and-assess-rat-behaviour
#18
Magda J Castelhano-Carlos, Vera Baumans, Nuno Sousa
The use of animals is essential in biomedical research. The laboratory environment where the animals are housed has a major impact on them throughout their lives and influences the outcome of animal experiments. Therefore, there has been an increased effort in the refinement of laboratory housing conditions which is explicitly reflected in international regulations and recommendations. Since housing conditions affect behaviour and brain function as well as well-being, the validation of an animal model or paradigm to study the brain and central nervous system disorders is not complete without an evaluation of its implication on animal welfare...
February 2017: Laboratory Animals
https://www.readbyqxmd.com/read/26946120/studying-skin-tumourigenesis-and-progression-in-immunocompetent-hairless-skh1-hr-mice-using-chronic-7-12-dimethylbenz-a-anthracene-topical-applications-to-develop-a-useful-experimental-skin-cancer-model
#19
Giju Thomas, Bastiaan Tuk, Ji-Ying Song, Hoa Truong, Hans C Gerritsen, Frank R de Gruijl, Henricus J C M Sterenborg
Previous studies have established that 7,12-dimethylbenz(a)anthracene (DMBA) can initiate skin tumourigenesis in conventional furred mouse models by acting on hair follicle stem cells. However, further cancer progression depends on repeated applications of tumour promoter agents. This study evaluated the timeline involved in skin tumourigenesis and progression in immunocompetent hairless SKH1-hr mice with dysfunctional hair follicles using only DMBA with no additional tumour promoter agents. The results showed that topical application of 30 µg (117 nmol) of DMBA over the back and flank regions of the mouse once a week and 15 µg (58...
February 2017: Laboratory Animals
https://www.readbyqxmd.com/read/26946119/use-of-ultrasound-imaging-for-the-diagnosis-of-abnormal-uterine-bleeding-in-the-bonnet-macaque-macaca-radiata
#20
Uddhav K Chaudhari, M Imran, Dhananjay D Manjramkar, Siddhanath M Metkari, Nilesh P Sable, Dnyaneshwar S Gavhane, Rajendra R Katkam, Geetanjali Sachdeva, Meenakshi H Thakur, Sanjeeva D Kholkute
Ultrasound is a powerful, low-cost, non-invasive medical tool used by laboratory animal veterinarians for diagnostic imaging. Sonohysterography and transvaginal ultrasound are frequently used to assess uterine anomalies in women presenting with abnormal uterine bleeding (AUB). In the present study, we have evaluated the abdominal ultrasound of bonnet monkeys ( n = 8) showing spontaneous ovulatory ( n = 5) and anovulatory ( n = 3) AUB. The ovulatory ( n = 5) macaques showed cyclic AUB for 7-8 days...
February 2017: Laboratory Animals
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