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Laboratory Animals

Jose Orellana, Eleanor Weir
No abstract text is available yet for this article.
June 2017: Laboratory Animals
Paulin Jirkof, Beat M Riederer, Arieh Bomzon
No abstract text is available yet for this article.
June 2017: Laboratory Animals
Grupo de Trabajo de la Secal
No abstract text is available yet for this article.
June 2017: Laboratory Animals
Beat M Riederer, Arieh Bomzon, Paulin Jirkof
Good communication is important for the dissemination of research results. Here, we summarize the advice that was given to authors at the LA seminar on scientific writing at the FELASA Congress 2016 in Brussels, Belgium on 13-16 June 2016, with the aim of improving the quality of submitted papers and of avoiding common mistakes in scientific reports. See .
June 2017: Laboratory Animals
Ekaterina A Litvinova, Elena N Kozhevnikova, Ksenia M Achasova, Galina V Kontsevaya, Mikhail P Moshkin
Infections with Helicobacter spp. are known to have serious effects on rodent health, especially in immunocompromised animals. In this study three approaches were used to eradicate Helicobacter spp. infection in mice with a deficiency in intestinal proteoglycan (mucin2), namely triple oral antibiotic therapy (amoxicillin, clarithromycin and metronidazole), cross-fostering of neonatal pups by surrogate mothers negative for Helicobacter spp., and in vitro fertilization (IVF) with embryo transfer into Helicobacter-free mothers...
June 2017: Laboratory Animals
Sara Hestehave, Gordon Munro, Tina Brønnum Pedersen, Klas S P Abelson
Researchers performing experiments on animals should always strive towards the refinement of experiments, minimization of stress and provision of better animal welfare. An adequate analgesic strategy is important to improve post-operative recovery and welfare in laboratory rats and mice. In addition, it is desirable to provide post-operative analgesia using methods that are minimally invasive and stressful. This study investigated the antinociceptive effects of orally administered buprenorphine ingested in Nutella® in comparison with subcutaneous buprenorphine administration...
June 2017: Laboratory Animals
Louise Saul, Dario Besusso, Richard J Mellanby
The pathogenesis of human autoimmune disorders is incompletely understood. This has led to the development of numerous murine models in which the pathogenesis of autoimmunity can be probed and the efficacy of novel therapies can be tested. One of the most widely-used murine models of autoimmunity is experimental autoimmune encephalomyelitis (EAE). To induce autoimmune pathology, mice are often immunized with an autoantigen alongside an adjuvant, typically complete Freund's adjuvant (CFA). Unfortunately, CFA causes significant inflammation at the site of administration...
June 2017: Laboratory Animals
Vivi Flou Hjorth Jensen, Anne-Marie Mølck, Martin Mårtensson, Mette Aagaard Strid, Melissa Chapman, Jens Lykkesfeldt, Ingrid Brück Bøgh
Group housing is considered to be important for rats, which are highly sociable animals. Single housing may impact behaviour and levels of circulating stress hormones. Rats are typically used in the toxicological evaluation of insulin analogues. Human insulin (HI) is frequently used as a reference compound in these studies, and a comparator model of persistent exposure by HI infusion from external pumps has recently been developed to support toxicological evaluation of long-acting insulin analogues. However, this model requires single housing of the animals...
June 2017: Laboratory Animals
Julia Zorn, Bärbel Ritter, Manuel Miller, Monika Kraus, Emily Northrup, Markus Brielmeier
One limitation to housing rodents in individually ventilated cages (IVCs) is the ineffectiveness of traditional health monitoring programs that test soiled bedding sentinels every quarter. Aerogen transmission does not occur with this method. Moreover, the transmission of numerous pathogens in bedding is uncertain, and sentinel susceptibility to various pathogens varies. A novel method using particle collection from samples of exhaust air was developed in this study which was also systematically compared with routine health monitoring using soiled bedding sentinels...
June 2017: Laboratory Animals
Verena Reupke, Karoline Walliser, Thorsten Perl, Sarah Kimmina, Anke Schraepler, Michael Quintel, Nils Kunze-Szikszay
The aim of this study was to evaluate a total intravenous anaesthesia (TIVA) protocol using propofol and sufentanil without neuromuscular blocking agents (NBAs) for a non-recovery lung pathology study in rabbits including 10 h of pressure-controlled ventilation. TIVA was started with 20 mg/kg/h propofol and 0.5 µg/kg/h sufentanil. The depth of anaesthesia was assessed by reflex testing and monitoring of spontaneous movements or respiratory efforts. Vital parameters were monitored to assess the effects of the TIVA protocol...
June 2017: Laboratory Animals
Murat Uysal, Serdar Savaş Gül, Serhat Karaman, Ufuk Tas, Hilal Irmak Sapmaz, Funda Uysal, Kursad Aytekin, Mehmet Kemal Tümer
Intraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. Whether the caecum is located in the right caudal quadrant or left caudal quadrant in the abdominal cavity is not clear. For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. Two hundred Wistar albino rats and 100 BALB/c mice were used. The location of the caecum was determined by revealing the intra-abdominal organs immediately following euthanasia, photographing the organs, and archiving the images...
June 2017: Laboratory Animals
Els van Asselt, Mahipal Choudhary, Francesco Clavica, Ron van Mastrigt
Urethane is a widely used anesthetic in animal lower urinary tract research. Our objective was to investigate the quality of anesthesia and the correlation between bladder (voiding) contractions, micturition pressure, bladder capacity and urethane dosage and body weight. Urethane was given subcutaneously and/or intraperitoneally (1.0-1.2 g/kg). The bladder was filled with saline and the bladder pressure was recorded continuously. Animals in which the subcutaneous/intraperitoneal ratio was higher needed less urethane...
June 2017: Laboratory Animals
David Muñoz Valverde, Clara Muñoz Mediavilla
No abstract text is available yet for this article.
April 2017: Laboratory Animals
Saskia Kliphuis
No abstract text is available yet for this article.
April 2017: Laboratory Animals
Arieh Bomzon
No abstract text is available yet for this article.
April 2017: Laboratory Animals
Antje Semrau, Susanne Gerold, Julia-Stefanie Frick, Franz Iglauer
Gastritis is a commonly diagnosed condition in non-human primates used in biomedical research. As in humans, Helicobacter pylori infection may cause gastritis. The following report presents a method of non-invasive detection and a successful treatment protocol for this common pathogen.
April 2017: Laboratory Animals
Sergi Barrera-Ochoa, Irene Gallardo-Calero, Andrea Sallent, Alba López-Fernández, Ramona Vergés, Jordi Giralt, Marius Aguirre-Canyadell, Roberto Velez
The aim is to create a new and safe experimental model of radiation-induced neurovascular histological changes with reduced morbidity and mortality for use with experimental microsurgical techniques. Seventy-two Sprague-Dawley rats (250-300 g) were divided as follows: Group I: control group, 24 rats clinically evaluated during six weeks; Group II: evaluation of acute side-effects (two-week follow-up period), 24 irradiated (20 Gy) rats; and Group III: evaluation of subacute side-effects (six-week follow-up period), 24 irradiated (20 Gy) rats...
April 2017: Laboratory Animals
Samuel J Jackson, Nick Andrews, Doug Ball, Ilaria Bellantuono, James Gray, Lamia Hachoumi, Alan Holmes, Judy Latcham, Anja Petrie, Paul Potter, Andrew Rice, Alison Ritchie, Michelle Stewart, Carol Strepka, Mark Yeoman, Kathryn Chapman
Rodent models produce data which underpin biomedical research and non-clinical drug trials, but translation from rodents into successful clinical outcomes is often lacking. There is a growing body of evidence showing that improving experimental design is key to improving the predictive nature of rodent studies and reducing the number of animals used in research. Age, one important factor in experimental design, is often poorly reported and can be overlooked. The authors conducted a survey to assess the age used for a range of models, and the reasoning for age choice...
April 2017: Laboratory Animals
Amy Robinson-Junker, Amelia Morin, Kathleen Pritchett-Corning, Brianna N Gaskill
As part of routine husbandry, an increasing number of laboratory mice receive nesting material in addition to standard bedding material in their cages. Nesting material improves health outcomes and physiological performance in mice that receive it. Providing usable nesting material uniformly and efficiently to various strains of mice remains a challenge. The aim of this study was to determine how bedding particle size, method of nesting material delivery, and processing of the nesting material before delivery affected nest building in mice of strong (BALB/cAnNCrl) and weak (C3H/HeNCrl) gathering abilities...
April 2017: Laboratory Animals
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