journal
https://read.qxmd.com/read/38216547/role-of-serine-arginine-protein-kinase-1-and-minichromosome-maintenance-protein-2-in-predicting-epithelial-ovarian-cancer-response-to-treatment-and-prognosis
#21
JOURNAL ARTICLE
Enas Elkholy, Asmaa Gaber Abdou, Alshimaa Mahmoud Alhanafy, Tarek Hashem, Reham Hassan, Mohamed Shehata
BACKGROUND: Serine-Arginine (SR) proteins are a conserved family of proteins involved in RNA splicing and are reported to be over-expressed in multiple cancers. The aim of the study is evaluation of the expression of Serine arginine protein kinase 1 (SRPK1) and Minichromosome maintenance protein 2 (MCM2) in epithelial ovarian cancer (EOC) and their correlation with clinicopathological features, response to therapy, progression-free survival (PFS), and cancer-specific survival (CSS). METHODS: This study was carried out on surgical specimens of 65 patients diagnosed with EOC which were submitted to immunohistochemical staining by SRPK1 and MCM2 antibodies...
January 3, 2024: Indian Journal of Cancer
https://read.qxmd.com/read/38185864/survival-outcomes-of-epithelial-ovarian-cancer-treated-at-a-tertiary-level-hospital-in-india
#22
JOURNAL ARTICLE
Rachel G Chandy, Vinotha Thomas, Ajit Sebastian, Thenmozhi Mani, Anitha Thomas, Anjana Joel, Thomas S Ram, Abraham Peedicayil
BACKGROUND: One needs to choose wisely between primary neoadjuvant chemotherapy and primary cytoreductive surgery in ovarian cancer. The aim was to determine the recurrence free survival and overall survival after surgery for epithelial ovarian cancer and also the risk factors for recurrence and death. METHODS: Electronic medical records of 322 women operated for ovarian, fallopian or primary peritoneal cancer between 2011 and 2015 were reviewed. Descriptive statistics were used to describe patients and their clinical outcomes...
January 3, 2024: Indian Journal of Cancer
https://read.qxmd.com/read/38424682/tata-memorial-centre-evidence-based-management-of-breast-cancer
#23
REVIEW
Tabassum Wadasadawala, Shalaka Joshi, Sushmita Rath, Palak Popat, Ayushi Sahay, Seema Gulia, Prabhat Bhargava, Revathy Krishnamurthy, Dileep Hoysal, Jessicka Shah, Mitchelle Engineer, Jyoti Bajpai, Bhavika Kothari, Rima Pathak, Dushyant Jaiswal, Sangeeta Desai, Tanuja Shet, Asawari Patil, Trupti Pai, Purvi Haria, Aparna Katdare, Sonal Chauhan, Shabina Siddique, Vaibhav Vanmali, Rohini Hawaldar, Sudeep Gupta, Rajiv Sarin, Rajendra Badwe
The incidence of breast cancer is increasing rapidly in urban India due to the changing lifestyle and exposure to risk factors. Diagnosis at an advanced stage and in younger women are the most concerning issues of breast cancer in India. Lack of awareness and social taboos related to cancer diagnosis make women feel hesitant to seek timely medical advice. As almost half of women develop breast cancer at an age younger than 50 years, breast cancer diagnosis poses a huge financial burden on the household and impacts the entire family...
January 1, 2024: Indian Journal of Cancer
https://read.qxmd.com/read/38424681/tata-memorial-centre-evidence-based-management-of-colorectal-cancer
#24
JOURNAL ARTICLE
Avanish Saklani, Mufaddal Kazi, Ashwin Desouza, Ankit Sharma, Reena Engineer, Rahul Krishnatry, Shivkumar Gudi, Vikas Ostwal, Anant Ramaswamy, Aditya Dhanwat, Prabhat Bhargava, Shaesta Mehta, Sridhar Sundaram, Aditya Kale, Mahesh Goel, Shraddha Patkar, Gurudutt Vartey, Suyash Kulkarni, Akshay Baheti, Suman Ankathi, Purvi Haria, Aparna Katdare, Amit Choudhari, Mukta Ramadwar, Munita Menon, Prachi Patil
This review article examines the evidence-based management of colorectal cancers, focusing on topics characterized by ongoing debates and evolving evidence. To contribute to the scientific discourse, we intentionally exclude subjects with established guidelines, concentrating instead on areas where the current understanding is dynamic. Our analysis encompasses a thorough exploration of critical themes, including the evidence surrounding complete mesocolic excision and D3 lymphadenectomy in colon cancers. Additionally, we delve into the evolving landscape of perioperative chemotherapy in both colon and rectal cancers, considering its nuanced role in the context of contemporary treatment strategies...
January 1, 2024: Indian Journal of Cancer
https://read.qxmd.com/read/38424680/tata-memorial-centre-evidence-based-use-of-nuclear-medicine-diagnostic-and-treatment-modalities-in-cancer
#25
JOURNAL ARTICLE
Ameya D Puranik, Sayak Choudhury, Suchismita Ghosh, Indraja D Dev, Varun Ramchandani, Abhishek Uppal, Vikrant Bhosale, Abhishek Palsapure, Rachita Rungta, Rakesh Pandey, Shweta Khatri, Gemson George, Yogesh Satamwar, Rahul Maske, Archi Agrawal, Sneha Shah, Nilendu C Purandare, Venkatesh Rangarajan
PET/CT and radioisotope therapy are diagnostic and therapeutic arms of Nuclear Medicine, respectively. With the emergence of better technology, PET/CT has become an accessible modality. Diagnostic tracers exploring disease-specific targets has led the clinicians to look beyond FDG PET. Moreover, with the emergence of theranostic pairs of radiopharmaceuticals, radioisotope therapy is gradually making it's way into treatment algorithm of common cancers in India. We therefore would like to discuss in detail the updates in PET/CT imaging and radionuclide therapy and generate a consensus-driven evidence based document which would guide the practitioners of Oncology...
January 1, 2024: Indian Journal of Cancer
https://read.qxmd.com/read/38159211/the-milan-system-for-reporting-salivary-gland-cytopathology-assessment-of-utility-and-the-risk-of-malignancy
#26
JOURNAL ARTICLE
Annu E Prakash, Renu Sukumaran, Nileena Nayak, K Lakshmi, Anitha Mathews, Jayasree Kattoor
BACKGROUND: Cytological diagnosis of salivary gland lesions furnishes several challenges to pathologists and clinicians owing to their diverse morphology and varying reporting terminology. The Milan system for reporting salivary gland cytopathology was proposed to overcome these defects. The aim of this study was to grade histopathologically diagnosed cases of salivary gland pathology using Milan system and to correlate Milan system with histopathological diagnosis. The study aims to assess the utility of the Milan system and the risk of malignancy in each category...
December 29, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38159208/nut-carcinoma-a-rare-case-series
#27
JOURNAL ARTICLE
Saroj Kumar Das Majumdar, Deepak Kumar Das, Sandip Kumar Barik, Amit Kumar Adhya, Girish Kumar Parida, Anupam Muraleedharan, Dillip Kumar Parida
No abstract text is available yet for this article.
December 29, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38159202/para-testicular-cellular-angiofibroma-af-angiomyofibroblastoma-amf-like-tumor-a-case-report-of-a-rare-diagnosis-in-an-elderly-male
#28
JOURNAL ARTICLE
Vinayak N Dave, Khushboo M Sahetia, Santosh Menon
Cellular angiofibroma (AF)/Angiomyofibroblastoma (AMF)-like tumor is a rare benign mesenchymal neoplasm. It is very challenging to distinguish benign versus malignant mass radiologically. It is of paramount importance to distinguish Cellular Angiofibroma (CAF) microscopically from its differential diagnoses. A 64-year-old man presented with scrotal swelling. Pathological examination showed features of cellular AF/AMF- like tumor, which shows positivity for CD34, with negativity for S-100 Protein, smooth muscle actin and desmin...
December 29, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38159212/incidental-appendiceal-neoplasms-single-centre-results
#29
JOURNAL ARTICLE
Hakan Ozdemir, Zehra Unal Ozdemir, Mehmet O Gul
BACKGROUND: Histopathological examination of appendectomy specimens may reveal malignancies. Based on these results, either appendectomy is sufficient or sometimes a further treatment protocol can be needed. In this study, malignancy-diagnosed cases on appendectomy specimen were examined. METHODS: Patients who underwent appendectomy between January 2013 and December 2018 with a pre-diagnosis of acute appendicitis were evaluated retrospectively and those cases with malignancy were included in the study...
December 27, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38159210/assaying-of-p53-autoantibodies-in-saliva-for-the-detection-of-oral-squamous-cell-carcinoma-a-road-not-taken
#30
JOURNAL ARTICLE
S V Sreelatha, Sukanya Shetty, Vimal K Karnaker, Ankeeta M Jacob, Chitta R Chowdhury
BACKGROUND: Autoantibody detection is a promising approach to cancer screening. Serum p53 antibodies have been time tested in various cancers, including oral squamous cell carcinoma (OSCC). This study is aimed to detect and determine the level of p53 autoantibodies (p53-AAbs) in saliva. The association of clinicopathological features among patients with and without OSCC was also explored as a novel method for the detection of autoantibodies. METHODS: One hundred preoperative saliva samples from patients with histologically confirmed OSCC and a hundred from normal healthy individuals were collected...
December 27, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38145907/clear-cell-urothelial-carcinoma-of-bladder-case-report-of-a-rare-and-aggressive-variant-with-review-of-literature
#31
JOURNAL ARTICLE
Khushboo M Sahetia, Vinayak N Dave, Mahendra Pal, Santosh Menon
Clear cell urothelial carcinoma is a rare variant of urothelial carcinoma. It's recognition and accurate diagnosis are essential in deciding appropriate treatment protocols considering the prognosis of this variant. A 57-year-old male presented with a history of hematuria and lower urinary tract symptoms for 6 months. Microscopically, the tumor was arranged in sheets and had a nested pattern. The tumor was composed of round to polygonal cells with abundant clear cytoplasm (>90% clear cell differentiation), resembling a conventional clear renal cell carcinoma...
December 21, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38095102/comparison-of-sedation-efficacy-of-intravenous-infusion-of-dexmedetomidine-versus-propofol-in-terms-of-opioid-consumption-in-patients-requiring-postoperative-mechanical-ventilation-after-head-and-neck-onco-surgeries-a-randomized-prospective-study
#32
JOURNAL ARTICLE
Anuradha Patel, Rakesh Garg, Sachidanand Jee Bharti, Vinod Kumar, Nishkarsh Gupta, Seema Mishra, Sushma Bhatnagar, Abhishek Kumar
BACKGROUND: The conventional drug regimen of sedation for patients requiring mechanical ventilation in an intensive care unit (ICU) is propofol or midazolam. Dexmedetomidine is a newer drug for sedation with a better clinical profile. We conducted this study to compare the sedative efficacy of dexmedetomidine versus propofol in patients after head and neck cancer surgeries requiring mechanical ventilation. METHODS: After ethics committee approval and written informed consent, 80 patients undergoing head and neck onco-surgery were recruited...
December 14, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38078445/the-effect-of-the-social-support-perceived-by-the-women-receiving-chemotherapy-on-functional-and-psychosocial-conditions-a-cross-sectional-descriptive-and-correlational-study
#33
JOURNAL ARTICLE
Hacer Ataman, Rujnan Tuna
BACKGROUND: Today, cancer is one of the most important health problems with fatal results. Individuals with cancer have to cope with many functional and psychosocial problems in the course of the disease besides physical impairments. The effect of social support of women receiving chemotherapy on their functional and psychosocial conditions was determined. METHODS: This study had a cross-sectional, descriptive, and correlational design. The study was conducted with 330 women patients in a state hospital located in Istanbul, Turkey, which has an outpatient chemotherapy unit and is one of the hospitals where outpatient chemotherapy is applied most...
December 7, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38078444/prevalence-of-asymptomatic-brain-metastases-in-metastatic-nonsquamous-nonsmall-cell-lung-cancer-treatment-implications-for-resource-constrained-settings
#34
JOURNAL ARTICLE
Shubham Shukla, Kuruswamy Thurai Prasad, Chirag Kamal Ahuja, Valliappan Muthu, Navneet Singh
BACKGROUND: Brain metastases (BM) are common in metastatic nonsmall cell lung cancer (NSCLC). However, routine neuroimaging in asymptomatic patients with metastatic NSCLC is controversial as there is no conclusive evidence of benefit from the detection and treatment of asymptomatic BM. Herein, we evaluated the prevalence of asymptomatic BM and its treatment implications in a resource-limited setting. METHODS: Consecutive patients with newly diagnosed, treatment-naïve, metastatic, nonsquamous NSCLC (NS-NSCLC) were included...
December 7, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38078466/prevalence-distribution-and-risk-markers-for-the-development-of-gonadal-germ-cell-tumors-in-patients-with-certain-types-of-disorders-of-sexual-differentiation-with-y-chromosome-a-retrospective-study
#35
JOURNAL ARTICLE
Darvin V Das, P K Jabbar, Ramesh Gomez, Bindu Nambisan, M S Bhuvitha, Abilash Nair, C Jayakumari
PURPOSE: To study the prevalence, subtypes, and risk markers for the development of gonadal germ cell tumors (GCT's) among disorders of sexual differentiation (DSD) patients with the Y chromosome. MATERIALS AND METHOD: Design: A retrospective review of the patient's case records from 2010 to 2020 in Government Medical College, Thiruvananthapuram, India was studied. The study participants included 54 subjects with DSD containing the Y chromosome. Demographic data, external masculinization scoring, associated congenital anomalies, karyotyping, intraoperative findings such as gonadal location and internal genital ducts, histopathology of the resected gonads, and its immunohistochemistry were collected...
December 6, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38078458/role-of-methylene-blue-dye-in-sentinel-node-biopsy-in-n0-oral-cavity-squamous-cell-carcinoma
#36
JOURNAL ARTICLE
Kiran Upadhyay, Vikas Gupta, Pankaj K Sahu, Abhijit Basu, Ritika Bhatia
BACKGROUND: Presence of neck nodes in cases of head neck squamous cell cancers is an adverse prognostic factor. Elective neck dissection is traditionally recommended along with primary disease resection. Sentinel lymph node (SLN) is the first draining node. Sentinel lymph node biopsy (SNB) is a minimally invasive technique to identify occult nodal metastasis in early HNSCC. METHODS: The objective of this study is to determine the identification rate of SNB using methylene blue dye (MBD) in N0 neck of Oral Squamous cell carcinoma (OSCC) and estimating specificity, sensitivity, negative predictive value and positive predictive value of SNB with frozen section (FS) analysis and in comparison to post-operative histopathological examination (HPE)...
December 3, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38078465/cd47-expression-in-urothelial-carcinoma-and-its-correlation-with-histopathological-findings
#37
JOURNAL ARTICLE
Ganime Çoban, Pelin Yıldız, Nurhan Şahin, Cevper Ersöz, Ali Toprak, Nurcan Ünver, Şahande Elagöz
BACKGROUND: The incidence of bladder cancers (BCs) is increasing day by day in both males and females with increased smoking. New treatment protocols are required due to the long follow-up times and high recurrence rates. CD47 (integrin-associated protein) is a membrane receptor that is effective in normal and pathophysiological events such as apoptosis, proliferation, adhesion, and immunity. Phagocytosis of both normal and tumor cells is prevented, by binding to the ligand signal regulatory protein-1 (SIRP-1)α on macrophages...
November 30, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38090959/analysis-of-discordant-pet-and-ct-findings-in-18f-fdg-pet-ct-scans-in-the-management-of-oncology-patients
#38
JOURNAL ARTICLE
Saumya S Sunny, Regi Oommen, Julie Hephzibah, Nylla Shanthly, David Mathew, Anu Eapen
BACKGROUND: Discordant findings are often noted between PET-CT and CT images of 18F-FDG PET-CT scans and cause ambiguity in image interpretation. This study aimed at determining the significance of these findings in the management of oncology patients. CONTEXT: Discordant findings are often noted between PET-CT and CT images of 18F-FDG PET-CT scans and cause ambiguity in image interpretation. AIM: This study aimed at determining the significance of these findings in the management of oncology patients...
November 2, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38258873/news-from-oncology
#39
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2023: Indian Journal of Cancer
https://read.qxmd.com/read/38258872/b-and-t-cells-in-immune-responses-friends-foes-or-innocent-contributors
#40
JOURNAL ARTICLE
Elisabeth Daguenet, Nicolas Magné
No abstract text is available yet for this article.
October 1, 2023: Indian Journal of Cancer
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