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Indian Journal of Cancer

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https://www.readbyqxmd.com/read/29292710/importance-of-repeat-tissue-biopsy-and-tissue-based-epidermal-growth-factor-receptor-t790m-testing-in-progressed-nonsmall-cell-lung-carcinoma-patients-upon-negative-plasma-genotyping-for-selection-of-third-generation-tyrosine-kinase-inhibitor-therapy-a-case
#1
R Mistry, A Patil
Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mutation on disease progression. Analysis of tumor tissue biopsy material is considered as gold standard for mutation detection. However, lung re-biopsy in a progressed patient involves several challenges - access to tumor, patient's willingness, safety, cost...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292709/a-review-on-adverse-event-profiles-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-in-nonsmall-cell-lung-cancer-patients
#2
REVIEW
B Biswas, N Ghadyalpatil, M V Krishna, J Deshmukh
The epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of EGFR-mutant nonsmall cell lung cancer (NSCLC). These EGFR TKIs demonstrate a different adverse event (AE) profile as compared to conventional chemotherapy agents. They are more commonly associated with cutaneous AEs and diarrhea while hematological AEs occurred commonly with chemotherapy agents. These AEs are the extension of pharmacological effect and occur as a result of blockade of EGFR-regulated pathways in the skin and gastrointestinal tract...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292708/epidermal-growth-factor-receptor-t790m-testing-in-progressed-lung-cancer-a-review-of-sensitive-methods-for-analysis-of-tissue-and-liquid-biopsy-samples
#3
REVIEW
A Chougule, S Basak
Lung cancer is one of the major causes of mortality worldwide and is on the rise in India. The identification of epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung cancer (NSCLC) has paved the way for personalized therapy in lung cancer with EGFR-tyrosine kinase inhibitors (TKIs). Despite the proven efficacy of EGFR-TKIs in patients harboring EGFR mutations, their clinical utility is limited by the development of acquired resistance mechanisms by the tumor cells. T790M mutation accounts for 60% of all resistance mechanisms to EGFR TKIs and is responsible for treatment failure with first- and second-generation TKIs...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292707/role-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-in-the-management-of-central-nervous-system-metastases-in-epidermal-growth-factor-receptor-mutation-positive-nonsmall-cell-lung-cancer-patients
#4
REVIEW
U Batra, N Lokeshwar, S Gupta, P Shirsath
Metastases to central nervous system (CNS) are very common in nonsmall cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)-positive mutation. Brain is the most affected part of CNS where blood-brain barrier (BBB) presents a challenge to currently available chemotherapeutic agents as well as first- (erlotinib and gefitinib) and second (afatinib)-generation EGFR tyrosine kinase inhibitors (TKIs) due to their poor penetrability. A rapid development of EGFR T790M secondary mutation is another cause of treatment failure, and patients tend to progress despite initial response to first- and second-generation EGFR TKIs...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292706/advanced-therapeutic-options-and-importance-of-rebiopsy-in-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-progressed-nonsmall-cell-lung-carcinoma-patients-an-expert-opinion
#5
REVIEW
Suresh H Advani, Hemant Malhotra, Raju Titus Chacko, Maheboob Basade, Pavithran Keechilat, P N Mahapatra, Chanchal Goswami, T P Sahoo, Chirag Shah
Advanced nonsmall cell lung cancer (NSCLC) treatment is primarily based on platinum-based chemotherapy. Although epidermal growth factor receptor (EGFR) targeting has shifted the treatment paradigm toward personalized tyrosine kinase inhibitors (TKIs), resistance develops inevitably and EGFR T790M is the most common acquired resistance mechanism. Rebiopsy of resistant NSCLC cases can provide additional information on the underlying resistant mechanisms and therefore can help clinicians in taking better management decisions...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292705/liquid-biopsy-a-potential-and-promising-diagnostic-tool-for-advanced-stage-non-small-cell-lung-cancer-patients
#6
REVIEW
D C Doval, R Deshpande, B Dhabhar, K G Babu, K Prabhash, R Chopra, P V Sripada, C Deshmukh, M Suryavanshi
More than 50% of non-small cell lung cancer (NSCLC) cases harbor an actionable mutation, and molecular testing at different intervals can help in personalized and targeted treatment. Core tissue biopsy and needle biopsy done at the time of diagnosis/disease progression are interventional, time-consuming and can affect the patients adversely. Noninterventional biomarker testing by liquid biopsy promises to revolutionize advanced stage cancer screening. The present report was formulated based on an expert panel meeting of renowned oncologists who gave their opinions for minimally invasive liquid biopsy to detect targetable molecular biomarkers in advanced NSCLC cases...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292704/epidermal-growth-factor-receptor-t790m-mutation-a-major-culprit-in-the-progression-of-epidermal-growth-factor-receptor-driven-non-small-cell-lung-cancer-and-the-role-of-repeat-biopsy
#7
REVIEW
S Aggarwal, S Patil, N Rohtagi
Non-small cell lung cancer (NSCLC) accounts for the majority of primary lung cancer cases worldwide. The activating mutations of epidermal growth factor receptor (EGFR) have been demonstrated to associate with the development of NSCLC, with T790M mutation being the most common. Over the years, EGFR tyrosine kinase inhibitors (TKIs) were developed to target EGFR-related mutations. However, patients with activating EGFR mutations who are initially responsive to EGFR-TKIs eventually develop acquired resistance after a median progression-free survival of 10-16 months, followed by disease progression...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292703/epidermal-growth-factor-receptor-mutation-testing-from-conventional-to-real-time-diagnosis-of-lung-cancer
#8
REVIEW
T Raja, N K Warrier
Patients with non-small cell lung cancer (NSCLC) commonly harbor epidermal growth factor receptor (EGFR) mutation. Due to the complex disease pathology, early-stage diagnosis of patients with EGFR mutation is essential to make appropriate treatment decision. Tyrosine kinase inhibitors (TKIs) are commonly used for their treatment, but almost half of the patients with EGFR mutation do not respond to the available TKIs and develop acquired resistance owing to T790M mutation. The presence of T790M mutation also warrants a robust diagnostic method so as to allow clinicians to modify cancer treatment...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292702/oncogenic-drivers-in-nonsmall-cell-lung-cancer-and-resistance-to-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors
#9
REVIEW
A Pathak, S Rajappa, A Gore
Nonsmall cell lung cancer (NSCLC) is increasingly being treated with targeted therapies. Epidermal growth factor receptor (EGFR) has been extensively studied in NSCLC as an oncogenic driver. However, the efficacy of the EGFR tyrosine kinase inhibitors (TKIs) is adversely impacted by the development of resistance. The occurrence of de novo resistance to EGFR TKIs is attributed to multiple mechanisms such as point mutations of oncogenes and chromosomal rearrangements. The development of acquired resistance to EGFR TKIs is facilitated by secondary mutations, phenotypical transformation, aberrance of downstream pathways, and activation of alternate signaling pathways...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082564/dr-ranjana-srivastava-oncologist-extraordinaire
#10
Sunil K Pandya
No abstract text is available yet for this article.
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082563/medial-plantar-artery-perforator-flap-for-reconstruction-of-the-soft-tissue-defect-of-heel-melanoma
#11
LETTER
Parth Kanaiyalal Patel, Shikha Tewari, Nitin Khunteta
No abstract text is available yet for this article.
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082562/surendra-nath-sehgal-a-pioneer-in-rapamycin-discovery
#12
LETTER
Debopam Samanta
No abstract text is available yet for this article.
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082561/eccrine-spiradenoma-a-rare-adnexal-tumor
#13
Singh Kanwaljeet, Tathagatta Chatterjee
Eccrine spiradenoma is one of the rare adnexal tumors with eccrine differentiation; however, it is considered to have apocrine differentiation. Around 50 cases of eccrine spiradenoma have been reported in the literature. Due to vascularity and painful symptoms, it is often confused with the painful lesions of skin such as glomus tumor and angioleiomyoma. Surgical excision is considered the gold standard for the treatment of these cases, with low rates of recurrence. Here, we present a 52-year-old male who presented with a nodular lesion in the left side of chest for the past 4 years...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082560/chylothorax-in-children-with-cancer-a-milky-predicament
#14
Sidharth Totadri, Amita Trehan, Anish Bhattacharya, Deepak Bansal, Savita Verma Attri, Radhika Srinivasan
Chylothorax is an uncommon complication in children. Although surgery and trauma are the most common causes encountered, hematological as well as solid malignancies can present with chylothorax. This study aimed to describe the presentation and management of malignant chylothorax in children. This is a case series from a pediatric hematology-oncology unit. Chylothorax was diagnosed by demonstrating high triglyceride content in the pleural fluid and a low cholesterol concentration in relation to the serum cholesterol...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082559/antibiotic-adjuvant-combinations-ceftriaxone-sulbactam-adjuvant-disodium-edetate-as-an-alternative-empiric-therapy-for-the-treatment-of-nosocomial-infections-results-of-a-retrospective-study
#15
Saibal Chakravorty, Prashant Arun
OBJECTIVE: Carbapenems are one of the last therapeutic options to treat various bacterial infections including multidrug resistant (MDR) nosocomial infections. However, excessive and inappropriate prescription of this drug has recently led to an epidemic rise in carbapenem resistance. Optimizing antibiotic utilization and exploring alternate options can be a potential way to control carbapenem resistance. The aim of this study was to assess the clinical efficacy of novel antibiotic adjuvant entity (ceftriaxone + sulbactam + ethylenediaminetetraacetic acid [EDTA] [CSE-1034]) in the treatment of various nosocomial infections...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082558/radiological-diagnosis-alone-risks-overtreatment-of-benign-disease-in-suspected-gallbladder-cancer-a-word-of-caution-in-an-era-of-radical-surgery
#16
Shraddha Patkar, Rajesh S Shinde, Sagar R Kurunkar, Devayani Niyogi, Nitin S Shetty, Mukta Ramadwar, Mahesh Goel
BACKGROUND: Incidental gallbladder cancer (iGBC) is on the rise world over. This may be a good scenario as we get to treat GBC in early stages. However, there is a practice of diagnosing patients based on clinicoradiological findings alone and subjecting them to a radical surgical procedure. This approach over-treats patient and has important implications for resource utilization. METHODS: We performed a retrospective analysis of 284 consecutive patients undergoing upfront surgery for suspected GBC from January 2010 to December 2016...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082557/efficacy-of-crizotinib-in-alk-mutant-non-small-cell-lung-cancers-that-are-positive-by-ihc-but-negative-by-fish-compared-to-fish-positive-cases
#17
Saurabh Zanwar, Vanita Noronha, Amit Joshi, Vijay M Patil, Rajiv Kaushal, Anuradha Chougule, Amit Janu, Abhishek Mahajan, Akhil Kapoor, Kumar Prabhash
BACKGROUND: A small proportion of Non-Small Cell Lung Cancers (NSCLC) are detected with Anaplastic Lymphoma Kinase (ALK) mutation by immunohistochemistry (IHC) but are negative by Fluorescence in situ Hybridization (FISH). Data on responses and outcome of this subset of patients when treated with crizotinib is limited. We analyzed the outcomes of such patients who received crizotinib. PATIENTS AND METHODS: Demographics, treatment details, response to treatment, date of progression and date of death were collected for patients who were IHC positive and FISH negative for ALK mutation from a prospectively maintained database...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082556/gallbladder-cancer-incidence-in-delhi-urban-a-25-year-trend-analysis
#18
Rajeev Kumar Malhotra, Nalliah Manoharan, N K Shukla, Gourva Kishore Rath
INTRODUCTION: Gallbladder cancer (GBC) falls into the top ten leading cancer sites in urban Delhi. The incidence of GBC in females is more than that among males worldwide. The present study evaluates the temporal variation of GBC incidence in an urban Delhi population. MATERIALS AND METHODS: The 25-year GBC incidence data were obtained from Population-Based Cancer Registry (PBCR) of Delhi which covered nearly 97.5% of the population and 75% of Delhi. We applied joinpoint regression method to determine the trend of GBC incidence from 1988 to 2012...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082555/cervical-esophago-gastric-anastomosis-using-linear-cutter-stapler-in-esophageal-cancer
#19
Parth Kanaiyalal Patel, Mishal Shah, Sanjeev Patni, Shashikant Saini
BACKGROUND: Anastomosis in gastrointestinal (GI) surgery is a commonly performed procedure. Irrelevant various methods of intestinal anastomosis were followed - recent advance is the use of a stapler as a device for GI anastomosis. Due to the use of staplers, technical failures are a rarity, anastomosis is more consistent and can be used at difficult locations. MATERIALS AND METHODS: : Between 2008 and August 2016, 75 patients with esophagus or gastroesophageal junction carcinoma underwent curative intent resection either via a right posterolateral thoracotomy (TTE) or transhiatal esophagectomy or video-assisted thoracoscopic surgery with linear stapler anastomosis...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30082554/a-comparative-phase-iii-clinical-study-to-evaluate-efficacy-and-safety-of-trasturel%C3%A2-biosimilar-trastuzumab-and-innovator-trastuzumab-in-patients-with-metastatic-human-epidermal-growth-factor-receptor-2-her2-overexpressing-breast-cancer
#20
Prasad Apsangikar, Sunil Chaudhry, Manoj Naik, Shashank Deoghare, Jamila Joseph
INTRODUCTION: The present study for biosimilar trastuzumab was a multicentric, randomized, two-arm parallel-group, comparative phase III study in patients with metastatic breast cancer. MATERIALS AND METHODS: Stage I of the study was conducted among 42 participants with equal distribution in the study and reference arm. After a loading dose of 8 mg/kg trastuzumab was administered intravenously on day 1 of the first cycle; serum samples were obtained at 0, 1.5 (end of IP infusion), 3, 6, 8, 24, 96, 168, and 336 h after the first infusion for the first cycle only...
October 2017: Indian Journal of Cancer
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