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Indian Journal of Cancer

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https://www.readbyqxmd.com/read/29199729/epidemiology-of-gynecological-cancers-in-kamrup-urban-district-cancer-registry
#1
D Barman, J D Sharma, D Barmon, A C Kataki, A Sharma, M Kalita
BACKGROUND: Cancers of the female reproductive system - namely cancer of the cervix, corpus uteri, ovarian, vulvar, vaginal, fallopian tube cancers and choriocarcinoma are an important cause of cancer morbidity and mortality among women worldwide. It is estimated to be the third most common group of malignancies in women. The comprehensive global cancer statistics from the International Agency for Research on Cancer indicate that gynaecological cancers accounted for 20% of the 14.1 million estimated new cancer cases and 8...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199728/testicular-seminoma-are-clinical-features-and-treatment-outcomes-any-different-in-india
#2
M Anjanappa, A Kumar, S Mathews, J Joseph, K M Jagathnathkrishna, F V James
AIM: This study aims to identify clinical features, treatment outcomes, and prognostic factors for relapse and survival in patients with testicular seminoma. MATERIALS AND METHODS: Retrospective analysis of all patients with pure seminoma treated at our center during over a decade (January 2005-December 2014) was carried out. Patient demographics, tumor characteristics, and treatment details and pattern of recurrence were recorded in a structured format, and disease-free survival and overall survival were calculated...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199727/evaluation-of-dose-conformity-and-coverage-of-target-volume-for-intensity-modulated-radiotherapy-of-pelvic-cancer-treatment
#3
M Atiq, A Atiq, K Iqbal, Q Shamsi, F Andleeb, S A Buzdar
BACKGROUND: Better conformity may help in delivering minimum dose to organs at risk (OARs) and maximum dose to planning target volume (PTV). As per the requirements of modern radiotherapy, 95% isodose should cover the PTV, so conformity indices (CIs) are used for evaluating quality of conformation of treatment plans. AIM: This study aimed to investigate degree of conformity for pelvic patients using intensity-modulated radiotherapy (IMRT) technique. Three formulas of CIs described in literature were analyzed in this study...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199726/role-and-relevance-of-braf-mutations-in-risk-stratifying-patients-of-papillary-thyroid-cancers-along-with-a-review-of-literature
#4
A Krishnamurthy, V Ramshankar, K Murherkar, S Vidyarani, G C Raghunandhan, A Das, P B Desai, K Albert
INTRODUCTION: Molecular markers are increasingly being explored as a potential diagnostic and prognostic tool in patients with well-differentiated thyroid cancers and B-type Raf kinase (BRAF) V600E mutation has received a wide attention in this regard. Many clinical studies have demonstrated an association of BRAF V600E mutation with aggressive clinicopathologic characteristics and high tumor recurrence and mortality in patients with papillary thyroid cancers. Papillary thyroid cancers has been abbreviated and PTCs...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199725/rechallenge-temozolomide-in-glioma-a-case-series-from-india
#5
V M Patil, R Tonse, R Kothari, A Chandrasekaran, N Pande, S Epari, T Gupta, R Jalali
INTRODUCTION: Temozolomide (TMZ) is an integral part of upfront treatment of high-grade gliomas. It is administered postsurgery as concurrent therapy with radiation and subsequently as adjuvant chemotherapy for 6-12 cycles. It is unknown whether rechallenge of salvage TMZ in previously treated high-grade glioma has any efficacy. MATERIAL AND METHODS: Patients treated with salvage rechallenged TMZ between January 2015 and August 2016 were included for this retrospective analysis...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199724/survival-and-prognostic-factors-for-glioblastoma-multiforme-retrospective-single-institutional-study
#6
M Ghosh, S Shubham, K Mandal, V Trivedi, R Chauhan, S Naseera
INTRODUCTION: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. The standard management has been maximum surgical resection followed by adjuvant radiotherapy with concurrent chemotherapy followed by adjuvant chemotherapy. Although the survival rate of patients with GBM has improved with recent advancements in treatment, the prognosis remains generally poor. The median survival rates are in the range of 9-12 months and 2-year survival rates are in the range of 8%-12%...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199723/chemo-port-insertion-through-femoral-vein-approach-a-rare-indication-and-a-rare-complication
#7
LETTER
S G Dholaria, D Yadav, A K Gupta
No abstract text is available yet for this article.
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199722/composite-lymphomas-experience-from-a-tertiary-cancer-center-in-kerala-south-india
#8
J A Vasudevan, R A Nair, R Sukumaran, S G Nair
OBJECTIVES: Composite tumors are defined as tumors in which there are two different intermixed histologic types. Our objective was to study the clinical and pathologic features of five cases of composite lymphoma. MATERIALS AND METHODS: Our study included five patients of composite lymphoma diagnosed over a period of 5 years. Clinical presentation, hematological parameters including peripheral smear, bone marrow aspirate, and histopathological examination of lymph node including immunohistochemistry (IHC) were studied...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199721/predicting-loco-regional-recurrence-risk-in-t1-t2-breast-cancer-with-1-3-positive-axillary-nodes-postmastectomy-development-of-a-predictive-nomogram
#9
T Wadasadawala, S Kannan, S Gudi, A Rishi, A Budrukkar, V Parmar, T Shet, S Desai, S Gupta, R Badwe, R Sarin
BACKGROUND: Role of postmastectomy radiotherapy (PMRT) in early breast cancer with 1-3 positive axillary nodes is still controversial. Hence, there is a need to identify subgroup of patients who have sufficiently high risk of disease recurrence to benefit from PMRT. AIM: The aim is to evaluate clinical outcomes of patients postmastectomy having pathological T1-T2 tumors with 1-3 positive axillary lymph nodes (LNs) treated with adjuvant systemic therapy and develop a predictive nomogram...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199720/a-prospective-randomized-trial-comparing-capecitabine-based-chemoradiotherapy-with-5-fu-based-chemoradiotherapy-in-neoadjuvant-setting-in-locally-advanced-carcinoma-rectum
#10
K Singh, M K Gupta, R K Seam, M Gupta
INTRODUCTION: Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue compared with healthy tissue. As an oral agent, capecitabine can be administered in the outpatient setting, potentially providing FU exposure similar to a lowdose continuous infusion of 5FU...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199719/retrospective-study-of-efficacy-and-safety-of-neoadjuvant-docetaxel-carboplatin-and-trastuzumab-in-her2-positive-locally-advanced-and-oligometastatic-breast-cancer-an-indian-experience
#11
A Tiwari, A Gogia, Svs Deo, N K Shukla, S Mathur, D N Sharma
BACKGROUND: The neoadjuvant chemotherapy in HER2-positive breast cancer consists of a chemotherapy backbone and HER2-directed therapy. The increase in cardiotoxicity by the use of trastuzumab with an anthracycline-based regimen has led to the use of nonanthracycline-based alternative regimens. The docetaxel, carboplatin, and trastuzumab (TCH) are one such regimen. The efficacy and toxicity of this regimen have not been widely studied in Indian patients. AIMS: This retrospective study aims to evaluate the efficacy and toxicity of neoadjuvant TCH regimen in locally advanced and oligometastatic HER2-positive breast cancer in Indian patients...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199718/multiple-myeloma-experience-of-an-institute-in-limited-resource-setting
#12
Linu Abraham Jacob, M C Suresh Babu, K C Lakshmaiah, K Govind Babu, D Lokanatha, L K Rajeev, K N Lokesh, A H Rudresha, Ankit Agarwal, Sunny Garg
INTRODUCTION: Multiple myeloma (MM) is a plasma cell dyscrasias and an incurable clonal B-cell malignancy, with an annual incidence of 1% of all malignancies. The mainstay of treatment of myeloma is induction treatment followed by consolidation with autologous stem cell transplant (ASCT). However, still in a developing country like India where affordability is a major hurdle for health care, a number of MM patients are not able to undergo ASCT. AIM: To study the epidemiological features and outcome of MM patients treated in a limited resource setting...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199717/tumor-characteristics-and-metabolic-quantification-in-carcinoma-breast-an-institutional-experience
#13
I P Dubey, A Jain, M S Chauhan, R Kumar, S Agarwal, B Kishore, M G Vishnoi, D Paliwal, A R John, N Kumar, A Sharma, A G Pandit
BACKGROUND: In India, carcinoma breast is the most common cancer among urban women population and second most common cancer after carcinoma cervix in rural areas. One in 22 women in India develops carcinoma of the breast in their lifetime. Fluorine-18-fluoro-2-deoxy-D-glucose (18F-FDG) uptake in breast cancer usually indicates the degree of tumor metabolism and hence can predict its behavior and prognosis. On the other hand, the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) or neu state of breast cancer is a biomarker that provides important prognostic information in addition to predicting response to therapy...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199716/pattern-of-distant-metastasis-in-molecular-subtypes-of-carcinoma-breast-an-institutional-study
#14
S U Kunikullaya, J Poddar, A D Sharma, S Patel
BACKGROUND: Molecular subtypes of carcinoma breast show a particular pattern of distant metastasis, the knowledge of which can help to diagnose and intervene early in the course of the disease. AIM: The aim of this study was to investigate and establish an association between the molecular subtypes of carcinoma breast and the pattern of distant metastasis. SETTINGS AND DESIGN: Single arm, retrospective study. MATERIALS AND METHODS: Totally 400 patients of carcinoma breast (Stage I and II) were selected who were treated between January 2010 and December 2013...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199715/expanded-panel-test-detecting-mesenchymal-epithelial-transition-amplification-leading-to-effective-treatment-in-adenocarcinoma-lung
#15
LETTER
V M Noronha, S Jandyal, A Joshi, V M Patil, A Mahajan, K Prabhash
No abstract text is available yet for this article.
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199714/prognostic-factors-and-treatment-of-patients-with-advanced-synovial-sarcoma-a-single-center-experience
#16
O Ates, S Aksoy, H Yeter, V Sunar, N Kertmen, O Dizdar, A Turker, A Kars
BACKGROUND: Synovial sarcoma (SS) is a malignant mesenchymal tumor, which comprises 5%-10% of all the sarcomas. There is insufficient information on prognostic factors and salvage treatments of advanced SS. In this study, we aimed to further clarify the clinicopathological features, prognostic factors, and treatment modalities in advanced SS. MATERIALS AND METHODS: A total of 45 SS patients followed up between 2001 and 2015 at our cancer institute, Department of Medical Oncology, were retrospectively evaluated...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199713/stereotactic-body-radiation-therapy-for-hepatocellular-carcinoma-experience-from-a-tertiary-cancer-care-center-in-india
#17
R Madhavan, B Kunher, M Arunlal, H M Nair, U G Unnikrishnan, R Holla, D Makuny
AIM: The aim of this retrospective study is to assess the toxicity and tumor response of stereotactic body radiation therapy (SBRT) protocol for hepatocellular carcinoma (HCC) in our institution. BACKGROUND: Hepatocellular cancer is one of the leading cancers among men in India. In recent years, SBRT has emerged as a promising tool in the treatment of HCC. MATERIALS AND METHODS: Ten patients diagnosed as HCC with Barcelona Clinic Liver Cancer Stage B and C, treated with SBRT technique from January 2013 to December 2016, were included in this study...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199712/histopathological-analysis-of-meningioma-and-its-variants-a-study-of-fifty-cases
#18
S Srikanth
BACKGROUND: The study was conducted to know the various histopathological variants of meningiomas, the age incidence and sex ratio. MATERIALS AND METHODS: A retrospective and prospective analysis of all the samples sent for histopathology for 2 years during June 2013-May 2015 was done to diagnose meningioma and its variants. Cases were analyzed in detail about the complete clinical history, exact location, and clinical and radiological diagnosis. The majority of the cases were clinically and radiologically diagnosed as meningioma...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199711/venous-thromboembolism-in-cancer-patients-magnitude-of-problem-approach-and-management
#19
REVIEW
G Singh, A K Rathi, K Singh, D Sharma
Cancer is hypercoagulable state. Patients with cancer are at high risk to develop venous thromboembolism (VTE). Relative risk of developing VTE is approximately seven times higher in patients with active cancer. The incidence of occult malignancy is 7%-12% in patients with idiopathic deep vein thrombosis (DVT). However, little research has been focused on cancer with thromboembolism. Lowmolecularweight heparin most frequently used pharmacologic agents as recommended by established guidelines. The aim was to evaluate the magnitude of problem in cancer patients and treatment option as per established guidelines...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199710/incidence-and-characteristics-of-epidermal-growth-factor-receptor-egfr-mutation-in-non-small-cell-lung-cancer-adenocarcinoma-histology-a-report-of-106-patients-from-kolkata
#20
K Chatterjee, A Ray, B Chattopadhyay
CONTEXT: Regional epidemiological data regarding the epidermal growth factor receptor (EGFR) mutation status in non-small-cell lung cancers (NSCLC) is an unmet need from the eastern part of India. AIMS: To report the incidence of EGFR mutation and its correlation with the phenotypical characteristics, in NSCLC patients from Kolkata. SUBJECTS AND METHODS: NSCLC patients, with adenocarcinoma histology, whose tissues had been tested for EGFR mutational status between March 2014 and February 2017, were considered for this study...
January 2017: Indian Journal of Cancer
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