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Indian Journal of Cancer

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https://www.readbyqxmd.com/read/29292710/importance-of-repeat-tissue-biopsy-and-tissue-based-epidermal-growth-factor-receptor-t790m-testing-in-progressed-nonsmall-cell-lung-carcinoma-patients-upon-negative-plasma-genotyping-for-selection-of-third-generation-tyrosine-kinase-inhibitor-therapy-a-case
#1
R Mistry, A Patil
Resistance to 1st or 2nd generation epidermal growth factor receptor (EGFR) - tyrosine kinases (TKIs) develops predominantly due to an acquired mutation, EGFR T790M. Third-generation EGFR-TKIs have demonstrated potent activity against TKI resistance mediated by EGFR T790M. Thus, it become critical to identify T790M mutation on disease progression. Analysis of tumor tissue biopsy material is considered as gold standard for mutation detection. However, lung re-biopsy in a progressed patient involves several challenges - access to tumor, patient's willingness, safety, cost...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292709/a-review-on-adverse-event-profiles-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-in-nonsmall-cell-lung-cancer-patients
#2
REVIEW
B Biswas, N Ghadyalpatil, M V Krishna, J Deshmukh
The epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of EGFR-mutant nonsmall cell lung cancer (NSCLC). These EGFR TKIs demonstrate a different adverse event (AE) profile as compared to conventional chemotherapy agents. They are more commonly associated with cutaneous AEs and diarrhea while hematological AEs occurred commonly with chemotherapy agents. These AEs are the extension of pharmacological effect and occur as a result of blockade of EGFR-regulated pathways in the skin and gastrointestinal tract...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292708/epidermal-growth-factor-receptor-t790m-testing-in-progressed-lung-cancer-a-review-of-sensitive-methods-for-analysis-of-tissue-and-liquid-biopsy-samples
#3
REVIEW
A Chougule, S Basak
Lung cancer is one of the major causes of mortality worldwide and is on the rise in India. The identification of epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung cancer (NSCLC) has paved the way for personalized therapy in lung cancer with EGFR-tyrosine kinase inhibitors (TKIs). Despite the proven efficacy of EGFR-TKIs in patients harboring EGFR mutations, their clinical utility is limited by the development of acquired resistance mechanisms by the tumor cells. T790M mutation accounts for 60% of all resistance mechanisms to EGFR TKIs and is responsible for treatment failure with first- and second-generation TKIs...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292707/role-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors-in-the-management-of-central-nervous-system-metastases-in-epidermal-growth-factor-receptor-mutation-positive-nonsmall-cell-lung-cancer-patients
#4
REVIEW
U Batra, N Lokeshwar, S Gupta, P Shirsath
Metastases to central nervous system (CNS) are very common in nonsmall cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)-positive mutation. Brain is the most affected part of CNS where blood-brain barrier (BBB) presents a challenge to currently available chemotherapeutic agents as well as first- (erlotinib and gefitinib) and second (afatinib)-generation EGFR tyrosine kinase inhibitors (TKIs) due to their poor penetrability. A rapid development of EGFR T790M secondary mutation is another cause of treatment failure, and patients tend to progress despite initial response to first- and second-generation EGFR TKIs...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292706/advanced-therapeutic-options-and-importance-of-rebiopsy-in-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-progressed-nonsmall-cell-lung-carcinoma-patients-an-expert-opinion
#5
REVIEW
Suresh H Advani, Hemant Malhotra, Raju Titus Chacko, Maheboob Basade, Pavithran Keechilat, P N Mahapatra, Chanchal Goswami, T P Sahoo, Chirag Shah
Advanced nonsmall cell lung cancer (NSCLC) treatment is primarily based on platinum-based chemotherapy. Although epidermal growth factor receptor (EGFR) targeting has shifted the treatment paradigm toward personalized tyrosine kinase inhibitors (TKIs), resistance develops inevitably and EGFR T790M is the most common acquired resistance mechanism. Rebiopsy of resistant NSCLC cases can provide additional information on the underlying resistant mechanisms and therefore can help clinicians in taking better management decisions...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292705/liquid-biopsy-a-potential-and-promising-diagnostic-tool-for-advanced-stage-non-small-cell-lung-cancer-patients
#6
REVIEW
D C Doval, R Deshpande, B Dhabhar, K G Babu, K Prabhash, R Chopra, P V Sripada, C Deshmukh, M Suryavanshi
More than 50% of non-small cell lung cancer (NSCLC) cases harbor an actionable mutation, and molecular testing at different intervals can help in personalized and targeted treatment. Core tissue biopsy and needle biopsy done at the time of diagnosis/disease progression are interventional, time-consuming and can affect the patients adversely. Noninterventional biomarker testing by liquid biopsy promises to revolutionize advanced stage cancer screening. The present report was formulated based on an expert panel meeting of renowned oncologists who gave their opinions for minimally invasive liquid biopsy to detect targetable molecular biomarkers in advanced NSCLC cases...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292704/epidermal-growth-factor-receptor-t790m-mutation-a-major-culprit-in-the-progression-of-epidermal-growth-factor-receptor-driven-non-small-cell-lung-cancer-and-the-role-of-repeat-biopsy
#7
REVIEW
S Aggarwal, S Patil, N Rohtagi
Non-small cell lung cancer (NSCLC) accounts for the majority of primary lung cancer cases worldwide. The activating mutations of epidermal growth factor receptor (EGFR) have been demonstrated to associate with the development of NSCLC, with T790M mutation being the most common. Over the years, EGFR tyrosine kinase inhibitors (TKIs) were developed to target EGFR-related mutations. However, patients with activating EGFR mutations who are initially responsive to EGFR-TKIs eventually develop acquired resistance after a median progression-free survival of 10-16 months, followed by disease progression...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292703/epidermal-growth-factor-receptor-mutation-testing-from-conventional-to-real-time-diagnosis-of-lung-cancer
#8
REVIEW
T Raja, N K Warrier
Patients with non-small cell lung cancer (NSCLC) commonly harbor epidermal growth factor receptor (EGFR) mutation. Due to the complex disease pathology, early-stage diagnosis of patients with EGFR mutation is essential to make appropriate treatment decision. Tyrosine kinase inhibitors (TKIs) are commonly used for their treatment, but almost half of the patients with EGFR mutation do not respond to the available TKIs and develop acquired resistance owing to T790M mutation. The presence of T790M mutation also warrants a robust diagnostic method so as to allow clinicians to modify cancer treatment...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29292702/oncogenic-drivers-in-nonsmall-cell-lung-cancer-and-resistance-to-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors
#9
REVIEW
A Pathak, S Rajappa, A Gore
Nonsmall cell lung cancer (NSCLC) is increasingly being treated with targeted therapies. Epidermal growth factor receptor (EGFR) has been extensively studied in NSCLC as an oncogenic driver. However, the efficacy of the EGFR tyrosine kinase inhibitors (TKIs) is adversely impacted by the development of resistance. The occurrence of de novo resistance to EGFR TKIs is attributed to multiple mechanisms such as point mutations of oncogenes and chromosomal rearrangements. The development of acquired resistance to EGFR TKIs is facilitated by secondary mutations, phenotypical transformation, aberrance of downstream pathways, and activation of alternate signaling pathways...
December 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469086/retraction-histopathological-analysis-of-meningioma-and-its-variants-a-study-of-fifty-cases
#10
(no author information available yet)
[This corrects the article DOI: 10.4103/ijc.IJC_119_17.].
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469085/autobiography-of-a-bosom
#11
R F Chinoy
No abstract text is available yet for this article.
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469084/summer-school-in-oncology-setting-a-benchmark-in-inspiring-the-future-oncologists-a-surgical-postgraduate-s-perspective
#12
LETTER
K N Rao, M V Jagade
No abstract text is available yet for this article.
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469083/knowledge-attitude-and-practice-toward-cervical-cancer-among-women-attending-obstetrics-and-gynecology-department-a-cross-sectional-hospital-based-survey-in-south-india
#13
G Narayana, M Jyothi Suchitra, G Sunanda, J Dasaratha Ramaiah, B Pradeep Kumar, K V Veerabhadrappa
INTRODUCTION: Cervical cancer-related deaths among women in India are often due to late diagnosis of disease. Knowledge about disease and early screening is the most effective measure for cervical cancer prevention. Lack of awareness, negative attitude, and poor practice about cervical cancer and screening are the major causes to increase the incidence of disease. AIM: The study is designed to assess knowledge, attitude, and practice (KAP) toward cervical cancer, screening, and prevention...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469082/novel-use-of-bioelectric-impedence-technique-to-detect-alterations-in-body-composition-in-advanced-small-cell-lung-cancer
#14
A Mohan, R Poulose, A Ansari, K Madan, V Hadda, G C Khilnani, R Guleria
BACKGROUND: Malnutrition is frequent in lung cancer and is measured using various tools, including the novel bioelectric impedance technique for measuring body composition. However, the validation of this technique for assessing body composition in advanced small cell lung cancer (SCLC) is untested. METHODS: Forty-one treatment naïve patients (all males) and an equal number of age- and sex-matched controls were evaluated by anthropometric measurements of skinfold thicknesses and body composition parameters such as body fat%, fat mass, fat-free mass (FFM), and total body water (TBW)...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469081/statins-and-risk-of-cancer-a-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#15
M K Kim, S K Myung, B T Tran, B Park
PURPOSE: Several meta-analyses of randomized controlled trials (RCTs) reported no association between the use of statins and the risk of cancer. However, they included open-label RCTs, which did not use placebo as a control group. This study aimed to evaluate the effect of statins on cancer risk using a meta-analysis of randomized, double-blind, placebo-controlled trials (RDBPCTs). METHODS: We searched PubMed, EMBASE, and the Cochrane Library in March 2016. Two individual authors reviewed and selected RDBPCTs based on selection criteria...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469080/role-change-as-breadwinner-in-cancer-caregiving
#16
C Sivakumar
INTRODUCTION: : Indian families are known for adopting the role of caregiver naturally when someone in the family falls ill to cancer. Although there were strong family structure and system existed here, now the changing family pattern and structure are challenging the role of cancer caregiving as well. OBJECTIVE: : This study analyses the life situation of caregivers of cancer survivors during the course of treatment and attempts to explore the areas of interventions for caregivers themselves...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469079/impact-of-pictorial-warning-labels-on-tobacco-products-among-patients-attending-outpatient-department-of-a-dental-college-in-bangalore-city-a-cross-sectional-study
#17
N Vanishree, R R Narayan, N Naveen, D Bullapa, D Vignesh, N M P Raveendran
AIM: The aim of this study is to assess the knowledge, attitude, and impact of pictorial warnings present on tobacco packets among patients attending outpatient department of a dental college of Bangalore city. MATERIALS AND METHODS: A cross-sectional study was conducted among 419 patients through convenience sampling, using a structured close-ended questionnaire containing 35 questions. The participants were approached and invited to participate voluntarily. The data obtained were analyzed using descriptive statistics, Chi-square test and ANOVA...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469078/barriers-affecting-adherence-to-radiation-treatment-and-strategies-to-overcome-those-barriers
#18
R Rangarajan, K Jayaraman
BACKGROUND: The WHO defines adherence as the extent to which a patient's behavior coincides with recommendations from a health-care provider. Nonadherence to cancer treatment has a major impact on the therapeutic outcome. AIM OF THE STUDY: To assess the prevalence of nonadherence to radiation regimen and to analyze the factors that affect adherence to cancer treatment. MATERIALS AND METHODS: Patients receiving radiation treatment in our hospital were screened for adherence to appointment keeping and to the prescribed radiation regimen and patients who had unplanned treatment breaks during treatment were interviewed...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469077/carboplatin-based-concurrent-chemoradiation-therapy-in-locally-advanced-head-and-neck-cancer-patients-who-are-unfit-for-cisplatin-therapy
#19
V Noronha, V Sharma, A Joshi, V M Patil, S G Laskar, K Prabhash
BACKGROUND: Cisplatin-based chemoradiation (CTRT) is the standard of care in locally advanced head and neck cancers. Limited treatment options are available in patients unfit for cisplatin. AIMS: This audit was carried out to study the toxicities, tolerance, and outcomes of carboplatin-based CTRT in patients who are not eligible for cisplatin. MATERIALS AND METHODS: A total of 63 locally advanced head and neck cancer patients treated between January 2011 and October 2015 were administered carboplatin-based CTRT...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469076/quality-of-life-outcome-measures-using-university-of-washington-questionnaire-version-4-in-early-t1-t2-anterior-tongue-cancers-with-and-without-radiotherapy-a-cross-sectional-study
#20
P Sakthivel, D V K Irugu, C A Singh, H Verma, R Yogal, B Jat, A Chadran, K Sikka, A Thakar, S C Sharma
CONTEXT: To evaluate the quality of life (QOL) outcome measures in disease-free survivors of pathological T1/T2 tongue cancers and to compare QOL in patients treated with only surgery and with adjuvant treatment. SETTINGS AND DESIGN: Cross-sectional survey. PATIENTS AND METHODS: All pathological T1/T2 anterior tongue cancer cases with follow-up from January 2011 till December 2015, who had locoregionally controlled disease with a minimum disease-free survival period of 1 year, were included in the study...
April 2017: Indian Journal of Cancer
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