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Drug and Therapeutics Bulletin

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https://www.readbyqxmd.com/read/27908909/dtb-select-12-december-2016
#1
(no author information available yet)
Azithromycin of no benefit for asthma attacks ● Risk of heart failure with NSAIDs ● Bisphosphonates and steroid-induced osteoporosis ● Triple therapy for moderate-to-severe COPD: marginal benefits ● Much data on adverse events remains unpublished ● Rising placebo response rates in antidepressant trials a 'myth' ● Prenatal fetal RhD testing recommended.
December 1, 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27815301/a-history-of-rubella-immunisation
#2
(no author information available yet)
No abstract text is available yet for this article.
November 3, 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27799149/dtb-select-11-november-2016
#3
(no author information available yet)
Impact of hepatic enzyme-inducing drugs on levonorgestrel EHC ● New clinical rule to improve antibiotic prescribing to children ● The impact of nursery sickness policies on the treatment of conjunctivitis ● Patient safety alert for acute kidney injury ● Do strategies to reduce polypharmacy improve patient-relevant outcomes? ● When is a health app a medical device? ● Automated feedback reduces high-risk prescribing in primary care ● Quantifying resting heart rate as a predictor of disease.
October 31, 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27737908/point-of-care-crp-testing-in-the-diagnosis-of-pneumonia-in-adults
#4
(no author information available yet)
Respiratory tract infections (RTI) are among the most common acute conditions leading to GP consultations and to antibiotic prescribing in primary care, even though 70% are viral, and many others are minor self-limiting bacterial infections.(1-4) Between 0.5% and 1.1% of adults have community-acquired pneumonia every year in the UK, most of whom are managed in primary care.(4,5) The decision to prescribe antibiotics for an acute RTI in primary care is often based on clinical symptoms, which have low sensitivity and specificity, and high inter-observer variability...
October 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27737907/fosfomycin-for-utis
#5
(no author information available yet)
Fosfomycin trometamol is a broad spectrum antibiotic recently marketed in the UK for the treatment of acute uncomplicated lower urinary tract infections (UTIs) in adults(1,2) and in adult and adolescent females.(3) It is also indicated for prophylaxis in diagnostic and surgical transurethral procedures.(1-3) Fosfomycin was discovered in 1969 and the reference drug was first marketed as Monuril in France in 1986.(3,4) Although Monuril had UK marketing authorisation, it was never distributed in the UK. However, national guidance included the option of using unlicensed imported fosfomycin...
October 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27737906/21st-century-cure-19th-century-risk
#6
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27694107/dtb-select-10-october-2016
#7
(no author information available yet)
Updated competency framework for all prescribers ● The risks of under-prescribing in older patients ● Self-monitoring and self-management of oral anticoagulation ● Role of sunscreen in preventing basal cell and squamous cell skin cancers ● Tech-based weight-loss intervention ● NICE guidance on NAFLD ● Modest improvement in sinus symptoms with nasal irrigation ● Exercise to offset the detrimental effects of sedentary habits.
October 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27609426/understanding-observational-studies
#8
(no author information available yet)
The development of evidence-based medicine has encouraged clinicians to consider the best available evidence when making clinical decisions, individualised for the patient.(1,2) A hierarchy of levels of evidence about therapy is described, with the highest being meta-analyses and large, well-designed randomised controlled trials.(3-5) Lower down the hierarchy are observational studies, a group that includes cohort, case-control and cross-sectional studies. Here we describe the benefits and limitations of observational studies, and how to assess their quality...
September 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27609425/%C3%A2-nalmefene-time-for-last-orders
#9
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27585997/management-of-hidradenitis-suppurativa
#10
(no author information available yet)
Hidradenitis suppurativa is a recurring chronic inflammatory debilitating skin disease of the hair follicle that usually presents with painful, deep-seated and inflamed lesions in the apocrine gland-bearing areas of the body. The lesions often progress to become chronic with purulent discharge, sinus formation and scarring. Hidradenitis suppurativa is associated with systemic comorbidities, including metabolic syndrome and inflammatory bowel disease.(1) Long-term treatment is often necessary and requires coordination between primary care, dermatologists and surgeons...
September 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27574186/dtb-select-9-september-2016
#11
(no author information available yet)
Assessing the risk: high vs. low antibiotic prescribing rates for RTIs ● RCOG guidance on nausea and vomiting in pregnancy ● Medical devices-USA vs. EU ● More on opioids for RLS ● Acupuncture for migraine prevention ● NICE guidance on oral health in care homes ● Liraglutide and cardiovascular outcomes in type 2 diabetes ● How useful is the study you are reading or writing?
September 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27516168/medicines-excipients-and-dietary-intolerances
#12
(no author information available yet)
Medicinal products contain not only active drugs but also other ingredients included for a variety of purposes and collectively known as excipients.(1) People who wish to avoid a specific substance because of an allergy or intolerance may ask a healthcare professional about the constituents of a medicine and whether an alternative is available. In a previous article we discussed the issues facing people who wish to avoid certain substances for religious or cultural reasons.(2) Here, we provide an overview of several dietary conditions and the pharmaceutical issues that need to be considered by healthcare professionals advising on the suitability of a medicine...
August 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27516167/what-role-for-capsaicin-in-diabetic-peripheral-neuropathy
#13
(no author information available yet)
Peripheral neuropathy is a common long-term complication of diabetes mellitus. In many patients, neuropathy is accompanied by pain, which is often difficult to manage effectively. Drug treatment options include certain antidepressants and antiepileptic drugs. Another option is the use of topical capsaicin. In this article, we consider the evidence for capsaicin in the management of diabetic peripheral neuropathy and how it fits with current management strategies.
August 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27493154/reading-between-the-guidelines
#14
(no author information available yet)
No abstract text is available yet for this article.
August 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27474505/dtb-select-8-august-2016
#15
(no author information available yet)
▼Canagliflozin and risk of lower limb amputation ● Antidepressants and young people ● Biological interventions for fatigue in RA ● Body shape in early and midlife linked to mortality ● COPD: LABA plus LAMA versus LABA plus ICS ● Safety warning for Nexplanon (etonogesterel) contraceptive implants ● Incorporating long-term prognosis into the care of older adults ● Impact of moderate-to-vigorous physical activity on cancer risk.
August 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27417322/%C3%A2-empagliflozin-diabetes-and-outcomes
#16
(no author information available yet)
The prevalence of type 2 diabetes is rising, and in 2015 more than 5% of adults in the UK were affected by this condition.(1,2) Management of type 2 diabetes includes encouraging lifestyle changes (increased exercise, modification of diet and smoking cessation) alongside the provision of medication to minimise long-term complications and manage blood sugar control while avoiding unwanted effects of drug treatment.(3) Of particular importance, people with type 2 diabetes are at increased risk of cardiovascular disease, and therefore the aims of treatment also include modification of associated risk factors...
July 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27405305/vitamin-supplementation-in-pregnancy
#17
(no author information available yet)
Ensuring that a woman is well-nourished, both before and during pregnancy, is crucial for the health of the woman and that of the unborn child.(1) Maternal deficiency in key nutrients has been linked to pre-eclampsia, restricted fetal growth, neural tube defects, skeletal deformity and low birth weight.(1,2) Many nutritional supplements containing vitamins, minerals and other micronutrients are heavily marketed to women for all stages of pregnancy. However, much of the evidence for vitamin supplementation in pregnancy comes from studies carried out in low-income countries,(3) where women are more likely to be undernourished or malnourished than within the UK population...
July 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27388604/dare-we-think-the-unthinkable
#18
(no author information available yet)
No abstract text is available yet for this article.
July 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27364828/dtb-select-7-july-2016
#19
(no author information available yet)
MHRA: avoid live vaccines in immunosuppressed patients ● Topical NSAIDs for musculoskeletal pain in adults ● Adherence to pregnancy prevention measures during isotretinoin treatment ● Impact of the NHS Health Check programme ● Ibuprofen: first choice for migraine in young people? ● Neuropsychiatric safety of ▼ varenicline and bupropion ● Effects of anticholinergic medication in cognitively normal older adults ● New NICE guidance for controlled drugs.
July 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/27284125/frailty-polypharmacy-and-deprescribing
#20
(no author information available yet)
Multimorbidity and associated polypharmacy present a significant and increasing challenge to patients, carers and healthcare professionals.(1,2) While it is recognised that polypharmacy can be beneficial, there is considerable potential for harm, particularly through drug interactions, adverse drug events and non-adherence.(1) Such harms are amplified in people who are frail and who may require interventions to be tailored to their individual needs rather than strictly following guidance designed to manage single diseases...
June 2016: Drug and Therapeutics Bulletin
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