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Tumori

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https://www.readbyqxmd.com/read/27834470/intraprostatic-chronic-inflammation-is-associated-with-a-reduced-risk-of-prostate-cancer-in-patients-elected-to-a-first-random-biopsy-set
#1
Antonio B Porcaro, Giovanni Novella, Nicolò de Luyk, Paolo Corsi, Giovanni Cacciamani, Marco Sebben, Alessandro Tafuri, Tania Processali, Mattia Cerasuolo, Maria A Cerruto, Matteo Brunelli, Salvatore Siracusano, Walter Artibani
OBJECTIVES: To investigate the associations of clinical factors and intraprostatic chronic inflammatory infiltrate (CII) with the risk of prostate cancer (PCa) in a large contemporary cohort of patients elected to a first random biopsy set. MATERIALS AND METHODS: The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCa in the period between September 2010 and September 2015. The multivariate logistic regression model investigated the possible associations of clinical factors and intraprostatic CII with PCa...
November 9, 2016: Tumori
https://www.readbyqxmd.com/read/27834469/the-expression-of-fat1-is-associated-with-overall-survival-in-children-with-medulloblastoma
#2
Jianzhong Yu, Hao Li
PURPOSE: The FAT1 gene is involved in some cancers; however, its role in medulloblastoma is less clear. This study investigated the effects of FAT1 expression on the prognosis of medulloblastoma patients. METHODS: Whole exome sequencing was undertaken in 40 medulloblastoma patient samples. FAT1 mRNA and protein expression levels in normal and brain tumor tissues were determined by fluorescence quantitative PCR and immunohistochemistry, respectively. The association of FAT1 expression with overall survival (OS) was examined by Kaplan-Meier curve analysis with a log-rank test...
November 8, 2016: Tumori
https://www.readbyqxmd.com/read/27834468/expression-of-cd74-in-invasive-breast-carcinoma-its-relation-to-nottingham-prognostic-index-hormone-receptors-and-her2-immunoprofile
#3
Eiman Adel Hasby, Rana Adel Khalifa
PURPOSE: To study the immunohistochemical expression of CD74 in series of invasive breast carcinomas classified according to their estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) immunoprofile and explore its correlation to Nottingham Prognostic Index (NPI) and tumor pathologic stage to determine if it has a prognostic value. METHODS: A total of 160 cases of mammary carcinoma were classified broadly according to their ER, PR, and HER2 expression into luminal, HER2-positive, and triple-negative groups...
October 29, 2016: Tumori
https://www.readbyqxmd.com/read/27791235/ethics-in-oncology-principles-and-responsibilities-declared-in-the-italian-ragusa-statement
#4
Stefania Gori, Carmine Pinto, Caterina Caminiti, Giuseppe Aprile, Paolo Marchetti, Francesco Perrone, Massimo Di Maio, Emanuela Omodeo Salè, Annamaria Mancuso, Maurizio De Cicco, Francesco Di Costanzo, Sergio Crispino, Rodolfo Passalacqua, Marco Merlano, Vittorina Zagonel, Luisa Fioretto, Giovanni Micallo, Roberto Labianca, Roberto Bordonaro, Alessandro Comandone, Sandro Spinsanti, Carmelo Iacono, Fabrizio Nicolis
Cancer care involves many ethical issues. The need for more patient-centered healthcare together with the improved empowerment of every person diagnosed with cancer have been transposed by the Italian Association of Medical Oncology (AIOM) and eventually translated in the Ragusa statement. This position paper describes the philosophy that lies beneath this document and its fundamental principles.
October 27, 2016: Tumori
https://www.readbyqxmd.com/read/27791234/cutaneous-toxicity-from-epidermal-growth-factor-receptor-inhibitors-would-a-subcutaneous-desensitization-be-helpful-case-report
#5
Andrea D'Alessio, Sara Cecchini, Daniela Di Mauro, Luca Geroli, Simonetta Villa, Antonello Quadri, Davide Resta, Carmelo Fortugno
PURPOSE: Cetuximab and panitumumab are monoclonal antibody inhibitors that bind the epidermal growth factor receptor (EGFR) currently used in the treatment of metastatic colorectal cancer. The main adverse event related to EGFR inhibitors (EGFR-Is) is cutaneous toxicity, which can cause dosage reduction and interruption of treatment. State-of-the-art management of skin toxicity associated with EGFR-Is therapy involves the topical administration of corticosteroids and oral antibiotics, but is not completely effective in the management of toxicity...
October 26, 2016: Tumori
https://www.readbyqxmd.com/read/27791232/treatment-of-advanced-renal-cell-carcinoma-recent-advances-and-current-role-of-immunotherapy-surgery-and-cryotherapy
#6
Alessia Mennitto, Elena Verzoni, Giuseppina Calareso, Carlo Spreafico, Giuseppe Procopio
Renal cell carcinoma (RCC) is the 10th most common cancer in Western countries. The prognosis of metastatic disease is unfavorable but may be different according to several risk factors, such as histology and clinical features (Karnofsky performance status, time from nephrectomy, hemoglobin level, neutrophils and thrombocytes count, lactate dehydrogenase and calcium serum value, sites and extension of the disease). In this review, we focused on some recent developments in the use of immunotherapy, surgery and cryotherapy in the treatment of advanced disease...
October 26, 2016: Tumori
https://www.readbyqxmd.com/read/27791231/clinical-factors-stratifying-the-risk-of-tumor-upgrading-to-high-grade-disease-in-low-risk-prostate-cancer
#7
Antonio B Porcaro, Salvatore Siracusano, Nicolò de Luyk, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Mattia Cerasuolo, Daniele Mattevi, Davide Inverardi, Maria A Cerruto, Matteo Brunelli, Walter Artibani
PURPOSE: To identify clinical factors stratifying the risk of tumor upgrading to increasing patterns of the tumor grading system in low-risk prostate cancer (PCa). METHODS: We evaluated the records of 438 patients who underwent radical prostatectomy. Associations between clinical factors and tumor upgrading were assessed by the univariate and multivariate multinomial logistic regression model. RESULTS: Low-risk PCa included 170 cases (38.8%) and tumor upgrading was detected in 111 patients (65...
October 26, 2016: Tumori
https://www.readbyqxmd.com/read/27791236/the-ats-ers-jrs-alat-statement-ipf-by-hrct-could-predict-acute-exacerbation-of-interstitial-lung-disease-in-non-small-cell-lung-cancer
#8
Nobuhiro Asai, Eisuke Katsuda, Rie Hamanaka, Kenshi Kosaka, Ayako Matsubara, Masaki Nishimura, Hiroyuki Tanaka, Norihito Yokoe, Ayumu Takahashi, Etsuro Yamaguchi, Akihito Kubo
INTRODUCTION: Patients with non-small cell lung cancer (NSCLC) and interstitial lung disease (ILD) are at high risk of acute exacerbation of ILD (AE-ILD) when treated with systemic chemotherapy. Standard treatment for NSCLC complicated by ILD has not been established. PURPOSE AND METHODS: To examine whether the type of ILD categorized by the official ATS/ERS/JRS/ALAT statement as "idiopathic pulmonary fibrosis (IPF) by high-resolution computed tomography (HRCT)" could predict chemotherapy-induced AE-ILD in NSCLC patients with ILD, we retrospectively reviewed all patients with NSCLC complicated by ILD who had received chemotherapy at our institute from January 2007 until December 2013...
October 22, 2016: Tumori
https://www.readbyqxmd.com/read/27791233/use-of-auc7-adjuvant-carboplatin-in-patients-with-stage-i-seminoma-systematic-review-of-the-literature
#9
Salvatore Siracusano, Alberto Diminutto, Antonio Benito Porcaro, Maria Angela Cerruto, Walter Artibani
PURPOSE: Among the adjuvant options to be proposed to patients with stage I seminoma after orchiectomy, the administration of a single cycle of carboplatin, at the dosage reaching an area under the curve of 7 mg/mL/min (AUC7), is a relatively recent introduction in clinical practice. METHODS: On April 1, 2016, we performed a systematic review of the literature to identify studies on the use of AUC7 carboplatin in the adjuvant setting for stage I seminoma patients...
October 22, 2016: Tumori
https://www.readbyqxmd.com/read/27768223/study-on-the-significance-of-cofilin-1-overexpression-in-human-bladder-cancer
#10
Fei Wang, Dinglan Wu, Fengrong He, Housheng Fu, Jianbing Xu, Jianxiang Chen, Shufang Zhang, Weifu Wang
PURPOSE: Cofilin 1 is a type of cytoskeletal protein. The overexpression of this gene has been regarded to hold a special relationship with the development and progress of some cancers. However, the detailed position of Cofilin 1 in human bladder cancer has not been investigated intensively. METHODS: In this study, we mainly explored the relationship between human bladder cancer and the expression of Cofilin 1. The expression of Cofilin 1 in bladder cancer tissues and paracancerous tissues of patients was evaluated with quantitative polymerase chain reaction, Western blot, and immunohistochemical staining...
October 21, 2016: Tumori
https://www.readbyqxmd.com/read/27841437/clinical-outcomes-of-recurrent-gastric-cancer-detected-by-upper-endoscopy-after-curative-total-gastrectomy
#11
Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim
BACKGROUND/AIMS: Endoscopically detected tumor recurrence after curative total gastrectomy is very rare. We reviewed the clinicopathological and endoscopic findings together with the clinical outcomes of these patients. METHODS: Seventeen patients with recurrent gastric cancer detected by upper gastrointestinal endoscopy who underwent curative total gastrectomy between January 1990 and May 2011 at the Asan Medical Center were analyzed retrospectively. RESULTS: Of the 17 patients, 5 were resectable at the time of diagnosis of recurrence and 12 were unresectable...
October 15, 2016: Tumori
https://www.readbyqxmd.com/read/27768222/histologic-subtypes-of-ovarian-carcinoma-selected-diagnostic-and-classification-problems-in-bulgaria-is-low-hospital-volume-an-issue
#12
Vesela Ivanova, Tihomir Dikov, Nadya Dimitrova
PURPOSE: To provide an overview of the morphologic subtypes of ovarian carcinomas in Bulgaria in relation to current healthcare organization using Bulgarian National Cancer Registry data. Further, we investigated hospital volume as a factor influencing the quality of care for patients with ovarian cancer. METHODS: Bulgarian National Cancer Registry ovarian carcinoma data were retrieved (2009-2011) and distribution of histologic types was analyzed. Cases were divided and compared with respect to main treatment: no surgery, surgery at hospitals dealing with ≥30 ovarian cancer patients/year (high volume), and surgery at hospitals dealing with <30 ovarian cancer patients/year (low volume)...
October 8, 2016: Tumori
https://www.readbyqxmd.com/read/27741348/the-rights-of-the-dying-child-and-the-duties-of-healthcare-providers-the-trieste-charter
#13
Franca Benini, Roberta Vecchi, Pierina Lazzarin, Momcilo Jankovic, Luciano Orsi, Luca Manfredini, Paola Drigo, Valentina Sellaroli, Michele Gangemi, Marco Spizzichino, Marcello Orzalesi
PURPOSE: The death of a child is a devastating and tragic event for all those involved. This charter aims to help healthcare workers and people assisting terminally ill children to recognize some important rights of the child, with some related suggestions. We consider it important to have a trace of this process, based on the skillfulness of long-lasting experts. METHODS: In September 2012, a group of professionals working with children affected by incurable illness in Italy launched a project to formulate the charter...
October 8, 2016: Tumori
https://www.readbyqxmd.com/read/27716883/lodds-is-superior-to-lymph-node-ratio-for-the-prognosis-of-node-positive-rectal-cancer-patients-treated-with-preoperative-radiotherapy
#14
Ben Huang, Mengdong Ni, Chen Chen, Guoxiang Cai, Sanjun Cai
PURPOSE: Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT. METHODS: We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database...
October 3, 2016: Tumori
https://www.readbyqxmd.com/read/27716879/3d-vision-improves-outcomes-in-early-cervical-cancer-treated-with-laparoscopic-type-b-radical-hysterectomy-and-pelvic-lymphadenectomy
#15
Francesco Raspagliesi, Giorgio Bogani, Fabio Martinelli, Mauro Signorelli, Cono Scaffa, Ilaria Sabatucci, Domenica Lorusso, Antonino Ditto
PURPOSE: To evaluate the alterations on surgical outcomes after of the implementation of 3D laparoscopic technology for the surgical treatment of early-stage cervical carcinoma. METHODS: Data of patients undergoing type B radical hysterectomy (with or without bilateral salpingo-oophorectomy) and pelvic lymphadenectomy via 3D laparoscopy were compared with a historical cohort of patients undergoing type B radical hysterectomy via conventional laparoscopy. Complications (within 60 days) were graded per the Accordion severity system...
October 3, 2016: Tumori
https://www.readbyqxmd.com/read/27716878/data-quality-in-rare-cancers-registration-the-report-of-the-rarecare-data-quality-study
#16
Annalisa Trama, Rafael Marcos-Gragera, Maria Josè Sánchez Pérez, Jan Maarten van der Zwan, Eva Ardanaz, Christine Bouchardy, Juan Manuel Melchor, Carmen Martinez, Riccardo Capocaccia, Massimo Vicentini, Sabine Siesling, Gemma Gatta
PURPOSE: Rare cancers represent 22% of all tumors in Europe; however, the quality of the data of rare cancers may not be as good as the quality of data for common cancer. The project surveillance of rare cancers in Europe (RARECARE) had, among others, the objective of assessing rare cancer data quality in population-based cancer registries (CRs). Eight rare cancers were considered: mesothelioma, liver angiosarcoma, sarcomas, tumors of oral cavity, CNS tumors, germ cell tumors, leukemia, and malignant digestive endocrine tumors...
October 3, 2016: Tumori
https://www.readbyqxmd.com/read/27716882/bilateral-lymph-node-micrometastases-and-seminal-vesicle-invasion-associated-with-same-clinical-predictors-in-localized-prostate-cancer
#17
Antonio B Porcaro, Nicolò de Luyk, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Irene Tamanini, Tania Processali, Maria A Cerruto, Filippo Migliorini, Matteo Brunelli, Salvatore Siracusano, Walter Artibani
AIM: To determine clinical factors associated with multiple bilateral lymph node micrometastases and seminal vesicle invasion (pT3b) in organ-confined prostate cancer (PCa). METHODS: The study excluded patients under androgen deprivation, with lymph node involvement (cN1 status), and having undergone unilateral pelvic lymph node dissection (PLND) during radical prostatectomy (RP). Lymph node micrometastases were classified as unilateral (pN1m) and bilateral (pN1b)...
September 27, 2016: Tumori
https://www.readbyqxmd.com/read/27716880/peritoneal-metastases-from-adrenal-cortical-carcinoma-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#18
Paul H Sugarbaker
PURPOSE: Adrenal cortical carcinoma is a rare cancer that often presents in an advanced stage. Not only systemic metastases but also local recurrence and peritoneal metastases prevent long-term survival in these patients. METHODS: A profoundly symptomatic patient with extensive peritoneal metastases and local recurrence was treated using cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with melphalan as the chemotherapy agent. RESULTS: Relative sparing of the small bowel within the abdomen and pelvis allowed a visible complete resection of all cancer...
September 27, 2016: Tumori
https://www.readbyqxmd.com/read/27716877/simultaneous-integrated-bilateral-breast-and-nodal-irradiation-with-volumetric-arc-therapy-case-report-and-literature-review
#19
Alba Fiorentino, Umberto Tebano, Ruggero Ruggieri, Francesco Ricchetti, Filippo Alongi
AIM: For simultaneous bilateral breast cancer (SBBC) treatment, conventional radiotherapy (RT) has a number of critical shortcomings. Thus, the usefulness of volumetric arc therapy (VMAT) for SBBC is undeniable. CASE REPORT: A 34-year-old woman with SBBC received neoadjuvant chemotherapy followed by breast-conserving surgery and bilateral lymph node dissection. Given the conservative surgery and the nodal involvement after neoadjuvant chemotherapy, bilateral adjuvant RT to the breasts and regional nodes with doses of 50 Gy in 25 fractions and a simultaneous integrated boost (SIB) of 60 Gy to the surgical bed was proposed...
September 27, 2016: Tumori
https://www.readbyqxmd.com/read/27716875/advantage-of-deep-inspiration-breath-hold-in-left-sided-breast-cancer-patients-treated-with-3d-conformal-radiotherapy
#20
Luciana Lastrucci, Simona Borghesi, Silvia Bertocci, Chiara Gasperi, Andrea Rampini, Giovanna Buonfrate, Paola Pernici, Roberta De Majo, Pietro Giovanni Gennari
PURPOSE: To compare 3D-conformal radiotherapy (3D-CRT) treatment plans based on free-breathing (FB) and deep inspiration breath hold (DIBH) and investigated whether DIBH technique enables a decrease of cardiac left anterior descending coronary artery (LADCA) and lungs dose with respect to the FB. METHODS: Twenty-three left-sided breast cancer patients referred for breast radiotherapy were included. The planning target volume (PTV) encompassed the breast and organs at risk including heart, LADCA, lungs, and contralateral breast, which were contoured in FB and DIBH CT scans...
September 27, 2016: Tumori
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