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Tumori

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https://www.readbyqxmd.com/read/28127742/performance-comparison-of-nextseq-and-ion-proton-platforms-for-molecular-diagnosis-of-clinical-oncology
#1
Fei Cao, Lianju Gao, Longgang Wei, Zhanni Chen, Yan Wang, Xia Ran, Xuehong Meng, Ji Tao
PURPOSE: Next-generation sequencing is a powerful approach to detect genetic mutations with which cancer diagnosis and treatment can be tailored to the individual patient in the era of personalized and precision medicine. Ion Torrent Systems Ion Proton and Illumina NextSeq are 2 major targeted sequencing platforms; however, not much work has been done to compare these platforms' performance for mutation detection in formalin-fixed paraffin-embedded (FFPE) materials. METHODS: We benchmarked the performance by using a collection of FFPE samples from 23 patients with different cancers for NextSeq and Ion Proton platforms...
January 25, 2017: Tumori
https://www.readbyqxmd.com/read/28127743/metachronous-solitary-metastasis-to-the-thyroid-gland-from-squamous-cell-carcinoma-of-the-lung-a-case-report-and-literature-review
#2
Francesco Gelsomino, Giuseppe Lamberti, Valentina Ambrosini, Francesca Sperandi, Roberto Agosti, Alessio G Morganti, Andrea Ardizzoni
INTRODUCTION: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. CASE DESCRIPTION: A 64-year-old Caucasian man previously treated with radiosurgery and brain metastasectomy followed by right middle lobectomy for a squamous cell lung carcinoma had a metachronous solitary metastasis to the thyroid gland, as confirmed by fine-needle aspiration cytology and open biopsy...
January 23, 2017: Tumori
https://www.readbyqxmd.com/read/28106245/a-randomized-controlled-trial-of-mediterranean-diet-and-metformin-to-prevent-age-related-diseases-in-people-with-metabolic-syndrome
#3
Patrizia Pasanisi, Giuliana Gargano, Maria Gaetana Di Mauro, Mauro Cortellini, Alice Casagrande, Anna Villarini, Eleonora Bruno, Eliana Roveda, Gabriella Saibene, Elisabetta Venturelli, Franco Berrino
PURPOSE: Age-related non-communicable chronic diseases (ArCDs) are the leading cause of mortality. The major metabolic risk factor for their development is the metabolic syndrome (MetS), defined as a clustering of risk factors of metabolic origin such as abdominal obesity, high blood pressure, dyslipidemia and high fasting glycemia. There is increasing observational and experimental evidence that improving diet and the use of metformin (a calorie-restriction mimetic drug) may modify the risk of developing MetS and ArCD...
January 20, 2017: Tumori
https://www.readbyqxmd.com/read/28106246/patient-centered-medicine-in-palliative-cancer-care-the-impossible-choice-between-physician-s-responsibility-and-patient-s-preferences
#4
Elena Vegni, Lidia Borghi
No abstract text is available yet for this article.
January 16, 2017: Tumori
https://www.readbyqxmd.com/read/28106244/second-malignancy-risk-in-patients-with-bronchopulmonary-carcinoids-epidemiological-results-from-italian-network-of-cancer-registries
#5
Filippo Lococo, Carla Galeone, Claudio Sacchettini, Giovanni Leuzzi, Alfredo Cesario, Massimiliano Paci, Lucia Mangone
PURPOSE: This epidemiological study aimed to determine the prevalence and characteristics of second tumors (STs) in patients with bronchopulmonary carcinoids (BCs). METHODS: Data on neuroendocrine carcinomas (NECs) from the AIRTUM registry (1975-2011) were used for the analysis. Among 32,325 NECs, we focused our analysis on 3,205 patients (9.9%) affected by BCs. The overall ST number and incidence were calculated. The number of STs was compared with the expected cancer number in the healthy Italian population, and the standardized incidence ratio (SIR) and 95% confidence intervals were calculated...
January 16, 2017: Tumori
https://www.readbyqxmd.com/read/28106243/author-s-reply-to-patient-centered-medicine-in-palliative-cancer-care-the-impossible-choice-between-physician-s-responsibility-and-patient-s-preferences
#6
Stefania Gori, Vittorina Zagonel
No abstract text is available yet for this article.
January 16, 2017: Tumori
https://www.readbyqxmd.com/read/28085179/comparison-of-neoadjuvant-vs-concurrent-adjuvant-androgen-deprivation-in-men-with-high-risk-prostate-cancer-receiving-definitive-radiation-therapy
#7
Anna Lee, Daniel J Becker, Ariel J Lederman, Virginia W Osborn, Meng S Shao, Andrew T Wong, David Schwartz, David Schreiber
PURPOSE: It is unknown whether there is a benefit to starting androgen deprivation therapy (ADT) prior to rather than concurrently with definitive radiation therapy in men with high-risk prostate cancer. We studied the National Cancer Data Base to determine whether the timing of ADT impacts survival. METHODS: Men diagnosed with high-risk prostate adenocarcinoma who received external beam radiation therapy (EBRT) to a dose of 70-81 Gy along with ADT from 2004-2011 were included...
January 12, 2017: Tumori
https://www.readbyqxmd.com/read/28085178/diabetes-mellitus-increases-the-risk-of-intrahepatic-recurrence-of-hepatocellular-carcinoma-after-surgical-resection
#8
Yunseon Choi, YoungKil Choi, Chang Soo Choi, Yun-Han Lee
AIMS AND BACKGROUND: The relationship between cancer and metabolism has recently been receiving attention. We investigated the prognostic influence of type 2 diabetes mellitus in patients with hepatocellular carcinoma (HCC) treated with curative resection. METHODS AND STUDY DESIGN: The records of 58 patients who underwent curative resection for HCC pT1-2N0M0 between 2010 and 2014 were reviewed retrospectively. Fourteen patients (24.1%) had diabetes mellitus at diagnosis...
January 7, 2017: Tumori
https://www.readbyqxmd.com/read/28085177/surgery-of-locally-advanced-and-metastatic-kidney-cancer-after-tyrosine-kinase-inhibitors-therapy-single-institute-experience
#9
Alberto De Gobbi, Davide Biasoni, Mario Catanzaro, Nicola Nicolai, Luigi Piva, Silvia Stagni, Tullio Torelli, Giuseppe Procopio, Elena Verzoni, Paolo Grassi, Maurizio Colecchia, Biagio Paolini, Carlo Spreafico, Alfonso Marchianò, Roberto Salvioni
PURPOSE: Renal cell carcinoma (RCC) is the most common tumor of the kidney. Considering the TNM classification of 2009, locally advanced and metastatic diseases are included in the groups stage III and IV. The surgical treatment of these tumors could be divided into 3 categories: (1) curative (nephrectomy and/or metastasectomy), (2) cytoreductive, and (3) palliative. Targeted agents showed impressive antitumor efficacy and prolongation of progression-free survival. The integration between target therapy and surgery in patients with locally advanced or metastatic RCC has sometimes facilitated surgery...
January 7, 2017: Tumori
https://www.readbyqxmd.com/read/28058710/stereotactic-ablative-radiotherapy-for-patients-with-unresectable-or-medically-inoperable-cholangiocarcinoma
#10
Ming-Yueh Liu, Cheng-Hsiang Lo, Chun-Shu Lin, Hsing-Lung Chao, Jen-Fu Yang, Kuen-Tze Lin, Chao-Yueh Fan, Yu-Fu Su, Wen-Yen Huang
PURPOSE: The role of stereotactic ablative radiotherapy (SABR) in patients with unresectable or medically inoperable cholangiocarcinoma remains unclear. We examined the efficacy and safety of SABR in this group of patients. METHODS: From January 2008 to December 2014, 15 patients with 17 lesions were included in this study. The lesions included 14 intrahepatic, 1 hilar, and 2 distal bile duct tumors. Three patients were classified as medically inoperable because of old age or multiple comorbidities...
January 5, 2017: Tumori
https://www.readbyqxmd.com/read/28058711/hyperglycemia-is-associated-with-poor-survival-in-primary-central-nervous-system-lymphoma-patients
#11
Ayumi Debata, Koichi Yoshida, Kenta Ujifuku, Haruna Yasui, Kensaku Kamada, Daisuke Niino, Takayuki Matsuo
PURPOSE: Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma (NHL), and it has been postulated that metabolic disorder may contribute to NHL etiology. We retrospectively investigated the prognostic significance of hyperglycemia in patients with PCNSL. We evaluated glucose transporter type 1 (GLUT1) expression by immunohistochemistry and analyzed its association with hyperglycemia and survival. METHODS: The medical and neuroradiologic records of 50 patients with PCNSL at our institution over the past 15 years were analyzed...
December 29, 2016: Tumori
https://www.readbyqxmd.com/read/28058713/advantage-of-sorafenib-combined-with-radiofrequency-ablation-for-treatment-of-hepatocellular-carcinoma
#12
Zhe Tang, Muxing Kang, Bo Zhang, Jianke Chen, Heqing Fang, Qin Ye, Biao Jiang, Yulian Wu
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Among the surgical and nonsurgical treatments available, radiofrequency ablation (RFA) and sorafenib have been shown to have efficacy. There is little evidence whether combination of these therapies would have additional benefits. METHODS: In a mouse model of HCC, effects of sorafenib were determined by tumor size, RFA-induced necrosis area (triphenyltetrazolium chloride staining), microvascular density (MVD; 4',6-diamidino-2-phenylindole and anti-CD31 antibody staining), and tumor perfusion (magnetic resonance imaging)...
December 26, 2016: Tumori
https://www.readbyqxmd.com/read/28058712/two-stage-hepatectomy-in-two-regional-district-community-hospitals-perioperative-safety-and-long-term-survival
#13
Guido Griseri, Michela Ceriotti, Andrea Percivale, Angelo Franceschi, Gregorio Santori, Marco Benasso, Riccardo Pellicci
INTRODUCTION: Surgical resection offers the best chance of cure for patients with colorectal liver metastases (CRLMs). Two-stage hepatectomy (TSH) has been demonstrated to be safe and effective to obtain curative resection in patients with multiple, bilobar CRLMs that are unresectable in a single procedure. Up to now TSH has been the prerogative of dedicated liver surgery centers. The aim of this study was to assess the safety and effectiveness of TSH also in community hospitals. METHODS: Of 294 patients operated on for CRLMs between September 1997 and June 2012 in 2 district community hospitals (belonging to the same regional healthcare district), 43 (14...
December 26, 2016: Tumori
https://www.readbyqxmd.com/read/28009428/high-dose-chemotherapy-and-peripheral-hematopoietic-stem-cell-transplantation-in-relapsed-refractory-hodgkin-s-lymphoma
#14
Mouhammed Kelta, Jamal Zekri, Ehab Abdelghany, Jalil Ur Rehman, Zahid Amin Khan, Rawan Al-Saadi, Reyad Dada
PURPOSE: High-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) is used to treat patients with relapsed Hodgkin's lymphoma. In this retrospective study we report our experience with patients who underwent HDCT and ASCT. METHODS: All patients ≥15 years old with relapsed/refractory Hodgkin's lymphoma who underwent HDCT and ASCT between June 2001 and December 2013 were included. RESULTS: Fifty-four patients were identified...
December 19, 2016: Tumori
https://www.readbyqxmd.com/read/28009427/first-italian-consensus-conference-on-vats-lobectomy-for-nsclc
#15
Mario Nosotti, Andrea Droghetti, Luca Luzzi, Piergiorgio Solli, Roberto Crisci
PURPOSE: Video-assisted thoracoscopic surgery (VATS) lobectomy has become an accepted procedure for the treatment of selected cases of lung cancer. The aim of this project was to establish national practical recommendations for the management of patients suitable for VATS lobectomy. METHODS: The Scientific Committee of the VATS Lobectomy Group (a branch of the Italian Society of Thoracic Surgery) identified the consensus conference as an appropriate tool for a national debate...
December 19, 2016: Tumori
https://www.readbyqxmd.com/read/28009426/-christmas-balls-a-christmas-carol-by-the-adolescent-cancer-patients-of-the-milan-youth-project
#16
Andrea Ferrari, Stefano Signoroni, Matteo Silva, Paola Gaggiotti, Laura Veneroni, Chiara Magni, Michela Casanova, Stefano Chiaravalli, Mirko Capelletti, Pietro Lapidari, Carlo Alfredo Clerici, Maura Massimino
The Youth Project is a program developed at the Pediatric Oncology Unit at the Istituto Nazionale Tumori in Milan, dedicated to adolescents and young adults with cancer. Among its various goals, the Youth Project organizes structured creative activities with the support of professionals, with the objective of offering young people a new way to express their hopes and fears. This article describes a project centered around music: patients created a Christmas carol with the help of musicians and authors. The adolescents explained with their own words the meaning of the lyrics, telling the story of a Christmas spent in a cancer hospital ward...
December 19, 2016: Tumori
https://www.readbyqxmd.com/read/28009423/synchronous-pancreatic-and-pulmonary-metastases-from-solitary-fibrous-tumor-of-the-pleura-report-of-a-case
#17
Nicola Tamburini, Nicolò Fabbri, Gabriele Anania, Pio Maniscalco, Francesco Quarantotto, Rosa Rinaldi, Giorgio Cavallesco
INTRODUCTION: Solitary fibrous tumor of the pleura is an uncommon tumor with an indolent course and a good prognosis after surgical resection. However, the tumor occasionally follows an unpredictable clinical course and malignant transformation has been reported to increase the rate of local recurrence. Solitary extrathoracic metastasis from solitary fibrous tumor of the pleura is an uncommon finding. CASE PRESENTATION: In this case report we present the first case of a synchronous single pulmonary and pancreatic metastasis treated with minimally invasive surgery...
December 19, 2016: Tumori
https://www.readbyqxmd.com/read/28009421/phase-ii-multi-institutional-clinical-trial-on-a-new-mixed-beam-rt-scheme-of-imrt-on-pelvis-combined-with-a-carbon-ion-boost-for-high-risk-prostate-cancer-patients
#18
Giulia Marvaso, Barbara A Jereczek-Fossa, Barbara Vischioni, Delia Ciardo, Tommaso Giandini, Azusa Hasegawa, Federica Cattani, Mauro Carrara, Mario Ciocca, Nice Bedini, Sergio Villa, Sara Morlino, Stefania Russo, Dario Zerini, Sarah Pia Colangione, Costanza Maria Vittoria Panaino, Cristiana Fodor, Luigi Santoro, Emanuele Pignoli, Francesca Valvo, Riccardo Valdagni, Ottavio De Cobelli, Roberto Orecchia
PURPOSE: Definition of the optimal treatment schedule for high-risk prostate cancer is under debate. A combination of photon intensity modulated radiotherapy (IMRT) on pelvis with a carbon ion boost might be the optimal treatment scheme to escalate the dose on prostate and deliver curative dose with respect to normal tissue and quality of dose distributions. In fact, carbon ion beams offer the advantage to deliver hypofractionated radiotherapy (RT) using a significantly smaller number of fractions compared to conventional RT without increasing risks of late effects...
December 2, 2016: Tumori
https://www.readbyqxmd.com/read/28009430/timing-should-no-longer-be-an-obstacle-to-oocyte-cryopreservation-in-patients-with-cancer
#19
Giorgia Mangili, Enrico Papaleo, Cristina Sigismondi, Rossella Masciangelo, Veronica Sarais, Veronica Giorgione, Roberta Nale, Laura Privitera, Letizia Carnelli, Valentina Di Mattei, Massimo Candiani
PURPOSE: Anticancer treatment-related infertility is preventable with oocyte cryopreservation, but this is often not considered a relevant issue, due to lack of knowledge and time. The aim of this study is to prove that adequate organization of an Oncofertility Unit and the use of new protocols for controlled ovarian stimulation (COS) can reduce the time required by the procedure, encouraging consultants and patients to preserve fertility before gonadotoxic treatments. METHODS: A total of 125 patients diagnosed with malignant tumors were referred to the Oncofertility Unit of San Raffaele Hospital: 52 patients between April 2011 and October 2013 and 73 patients between October 2013 and November 2015...
November 28, 2016: Tumori
https://www.readbyqxmd.com/read/28009425/gemcitabine-induced-thrombocytosis-as-a-potential-predictive-factor-in-non-small-cell-lung-cancer-analysis-of-318-patients
#20
Stefania Canova, Federica Cicchiello, Francesco Agustoni, Giampaolo Bianchini, Maria Ida Abbate, Paolo Bidoli, Diego Luigi Cortinovis
INTRODUCTION: In spite of the progress in the treatment of non-small-cell lung cancer (NSCLC), the majority of patients with advanced disease still receive chemotherapy. Gemcitabine alone or combined with a platinum compound is a valid option. Thrombocytosis is a recognized prognostic factor in lung cancer and an adverse event that may occur during gemcitabine infusion. METHODS: We retrospectively evaluated all patients with NSCLC treated with first-line gemcitabine-based chemotherapy in two Italian hospitals...
November 28, 2016: Tumori
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