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https://www.readbyqxmd.com/read/28623637/pure-small-cell-recurrent-prostate-cancer-developing-syndrome-of-inappropriate-antidiuretic-hormone-secretion
#1
Giorgia Peverelli, Paolo Grassi
PURPOSE: Pure small cell neuroendocrine carcinoma of the prostate is a rare entity characterized by a poor prognosis due to early metastatic spread as well as resistance to treatment. Considering its increasing occurrence, clinicians should be aware of its aggressive behavior, the relevance of an early diagnosis, and proper management. METHODS: A 71-year-old man treated with brachytherapy for localized low-risk prostate cancer developed widespread disease 7 years later with a prostate-specific antigen-negative neuroendocrine small cell phenotype...
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28623636/eleven-year-management-of-prostate-cancer-patients-on-active-surveillance-what-have-we-learned
#2
Cristina Marenghi, Maria Francesca Alvisi, Federica Palorini, Barbara Avuzzi, Fabio Badenchini, Nice Bedini, Lara Bellardita, Davide Biasoni, Davide Bosetti, Alessandra Casale, Mario Catanzaro, Maurizio Colecchia, Letizia De Luca, Simona Donegani, Paola Dordoni, Rodolfo Lanocita, Massimo Maffezzini, Tiziana Magnani, Julia Menichetti, Antonella Messina, Sara Morlino, Biagio Paolini, Tiziana Rancati, Silvia Stagni, Antonio Tesone, Tullio Torelli, Edoardo Tulli Baldoin, Marta Vaiani, Sergio Villa, Silvia Villa, Nadia Zaffaroni, Nicola Nicolai, Roberto Salvioni, Riccardo Valdagni
PURPOSE: To evaluate the outcomes of active surveillance (AS) on patients with low-risk prostate cancer (PCa) and to identify predictors of disease reclassification. METHODS: In 2005, we defined an institutional AS protocol (Sorveglianza Attiva Istituto Nazionale Tumori [SAINT]), and we joined the Prostate Cancer Research International: Active Surveillance (PRIAS) study in 2007. Eligibility criteria included clinical stage ≤T2a, initial prostate-specific antigen (PSA) <10 ng/mL, and Gleason Pattern Score (GPS) ≤3 + 3 (both protocols); ≤25% positive cores with a maximum core length containing cancer ≤50% (SAINT); and ≤2 positive cores and PSA density <0...
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28623635/italian-cultural-adaptation-of-the-memorial-anxiety-for-prostate-cancer-scale-for-the-population-of-men-on-active-surveillance
#3
Maria F Alvisi, Claudia Repetto, Tiziana Rancati, Fabio Badenchini, Tiziana Magnani, Cristina Marenghi, Silvia Villa, Nicola Nicolai, Roberto Salvioni, Barbara Avuzzi, Riccardo Valdagni, Lara Bellardita
PURPOSE: The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) is a self-report questionnaire that was developed in English to assess prostate cancer (PCa)-related anxiety. The aim of this study was to perform a cultural adaptation for the tool to be used in a population of Italian men on active surveillance (AS). METHODS: A total of 222 patients with localized PCa who were recruited for the Prostate Cancer Research International: Active Surveillance (PRIAS) protocol completed the MAX-PC...
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28623634/perfusion-bias-in-the-apparent-diffusion-coefficient-measurements-of-diffusion-weighted-magnetic-resonance-imaging
#4
Adriano M Priola, Andrea Veltri, Sandro M Priola
No abstract text is available yet for this article.
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28604996/one-lung-ventilation-for-thoracic-surgery-current-perspectives
#5
Filippo Bernasconi, Federico Piccioni
One-lung ventilation (OLV) is an anesthesiological technique that is increasingly being used beyond thoracic surgery. This requires specific skills and knowledge about airway management, maintenance of gas exchange and prevention of acute lung injury. Sometimes maintaining adequate gas exchange and minimizing acute lung injury may be opposing processes. Parameters validated for OLV titration still have not been found, but a multimodal approach based on low tidal volume, end-expiratory pressure application and alveolar recruitment maneuvers is considered the best way to ensure protective ventilation and reduce lung damage...
June 7, 2017: Tumori
https://www.readbyqxmd.com/read/28604998/role-of-radiotherapy-in-the-treatment-of-renal-cell-cancer-updated-and-critical-review
#6
Vincenzo Fusco, Salvatore Parisi, Barbara d'Andrea, Michele Troiano, Maria Antonietta Clemente, Franco Morelli, Rocchina Caivano, Giuseppe Guglielmi
PURPOSE: The growing incidence of renal cell carcinoma (RCC) raises many questions about the management of these patients. The late clinical presentation, the presence of locally advanced or metastatic disease at diagnosis, the difficulty of radical surgical excision, and radioresistance make it one of the more challenging tumors to treat. The primary objective of this article is to propose an updated and critical review of the role of radiotherapy (RT) in the treatment of RCC. METHODS: This literature review is based on data from meta-analyses and randomized, prospective, and retrospective studies...
June 6, 2017: Tumori
https://www.readbyqxmd.com/read/28604995/improving-healthcare-in-pediatric-oncology-development-and-testing-of-multiple-indicators-to-evaluate-a-hub-and-spoke-model
#7
Giulia Zucchetti, Nicoletta Bertorello, Angela Angelastro, Paola Gianino, Gianni Bona, Affif Barbara, Luigi Besenzon, Adalberto Brach Del Prever, Fernando Pesce, Marco Nangeroni, Franca Fagioli
PURPOSE: The hub-and-spoke is a new innovation model in healthcare that has been adopted in some countries to manage rare pathologies. We developed a set of indicators to assess current quality practices of the hub-and-spoke model adopted in the Interregional Pediatric Oncology Network in Northwest Italy and to promote patient, family, and professional healthcare empowerment. METHODS: Literature and evidence-based clinical guidelines were reviewed and multiprofessional team workshops were carried out to highlight some important issues on healthcare in pediatric oncology and to translate them into a set of multiple indicators...
June 6, 2017: Tumori
https://www.readbyqxmd.com/read/28604997/early-diagnosis-of-radiotherapy-failure-for-patients-with-head-and-neck-cancer-the-role-of-biochemical-markers
#8
Jolanta Mrochem-Kwarciak, Tomasz Rutkowski, Andrzej Wygoda, Regina Deja, Agata Hajduk, Krzysztof Składowski
PURPOSE: There is a lack of effective diagnostic tools for early assessment of radiotherapy (RT) outcome in patients with head and neck cancer (HNC). The timely diagnosis of treatment failure may facilitate use of salvage procedures to prevent disease progression. We assessed squamous cell carcinoma antigen and CYFRA 21-1 as early markers of radiotherapy failure in patients with HNC. METHODS: Between January 2009 and February 2012, 185 patients (median age 59 years) with squamous cell carcinoma were treated with curative intent with RT alone or combined with chemotherapy (ChT)...
June 2, 2017: Tumori
https://www.readbyqxmd.com/read/28574131/surprising-complete-response-of-intramedullary-spinal-cord-metastasis-from-breast-cancer-a-case-report-and-literature-review
#9
Dario Aiello, Rosario Mazzola, Fabiana Gregucci, Francesco Ricchetti, Niccolò Giaj Levra, Luigi Romano, Giovanni Carbognin, Matteo Salgarello, Alberto Beltramello, Filippo Alongi
PURPOSE: Intramedullary spinal cord metastases (ISCM) are considered rare but their incidence is rising. Most ISCM cases are recognized to occur in patients with stage IV lung cancer or breast cancer (BC). METHODS: We report a rare case of cervical BC-ISCM in 60-year-old woman, documented by magnetic resonance imaging and positron emission tomography-computed tomography and treated with volumetric modulated arc therapy with daily image-guided radiation therapy (VMAT/IGRT)...
May 29, 2017: Tumori
https://www.readbyqxmd.com/read/28574132/mirna-650-exerts-anti-leukemia-activity-by-inhibiting-cell-proliferation-through-gfi1-targeting
#10
Changyong Yuan, Liming Xu, Pengcheng Du, Jinling Pang
BACKGROUND: Acute myeloid leukemia (AML) is the most common malignancy of the bone marrow with a high mortality. Recent advances in high-throughput sequencing have led to the identification of various miRNAs implicated in the pathogenesis of AML. We found in this study that miR-650, a miRNA that was traditionally considered to participate in the onset of hepatocellular carcinoma, might play a significant role in AML development and progression. METHODS: qRT-PCR was used to detect the expression of miR-650 and Gfi1 in AML patients and healthy controls...
May 26, 2017: Tumori
https://www.readbyqxmd.com/read/28574130/hpv-related-vulvar-diseases-and-perspectives-of-p16ink4a-immunochemistry-a-review-of-the-literature
#11
Angela Carrone, Lucia Riganelli, Delia Savone, Assunta Casorelli, Lucia Merlino, Francesco Pecorini, Irene Pecorella, Pasquale Mancino, Maria Grazia Piccioni, Pierluigi Benedetti Panici
INTRODUCTION: Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap...
May 26, 2017: Tumori
https://www.readbyqxmd.com/read/28574129/smoking-in-italy-in-2015-2016-prevalence-trends-roll-your-own-cigarettes-and-attitudes-towards-incoming-regulations
#12
Alessandra Lugo, Piergiorgio Zuccaro, Roberta Pacifici, Giuseppe Gorini, Paolo Colombo, Carlo La Vecchia, Silvano Gallus
PURPOSE: In 2016, a series of selective tobacco regulations, which did not affect tobacco price, came into force in Italy. To understand how Italians accepted the new norms, we analyzed data from our 2 most recent surveys among those we annually conduct on tobacco. METHODS: In 2015 and 2016, we conducted 2 representative cross-sectional studies focused on the new forthcoming tobacco legislation on a total sample of 6,046 Italians aged ≥15 years. RESULTS: Overall, 21...
May 26, 2017: Tumori
https://www.readbyqxmd.com/read/28525684/223ra-dichloride-response-in-a-patient-with-paget-disease-and-bone-metastases-secondary-to-castration-resistant-prostate-cancer
#13
Lina García Cañamaque, Cristina Rioja Parada, Paloma García De la Peña
PURPOSE: Paget disease is commonly asymptomatic and discovered when an imaging test is performed for another clinical indication or when elevated serum alkaline phosphatase is found. Bone pain usually appears late in the disease process and is only present in a minority of patients. For diagnosis, X-ray and bone scan are the most recommended imaging methods; radionuclide imaging of the skeleton has become the standard, since it is the most sensitive test for detecting increased bone activity...
May 18, 2017: Tumori
https://www.readbyqxmd.com/read/28497846/survival-after-second-and-subsequent-recurrences-in-osteosarcoma-a-retrospective-multicenter-analysis
#14
Elisa Tirtei, Sebastian D Asaftei, Rosaria Manicone, Marilena Cesari, Anna Paioli, Michele Rocca, Stefano Ferrari, Franca Fagioli
PURPOSE: Osteosarcoma (OS) is the most common primary bone tumor. Despite complete surgical removal and intensive chemotherapeutic treatment, 30%-35% of patients with OS have local or systemic recurrence. Some patients survive multiple recurrences, but overall survival after OS recurrence is poor. This analysis aims to describe and identify factors influencing post-relapse survival (PRS) after a second OS relapse. METHODS: This is a retrospective analysis of 60 patients with a second relapse of OS of the extremities in 2 Italian centers between 2003 and 2013...
May 10, 2017: Tumori
https://www.readbyqxmd.com/read/28497847/pathogenesis-clinical-manifestations-and-management-of-immune-checkpoint-inhibitors-toxicity
#15
Alessandro Inno, Giulio Metro, Paolo Bironzo, Antonio M Grimaldi, Elisabetta Grego, Vincenzo Di Nunno, Virginia Picasso, Francesco Massari, Stefania Gori
Immune checkpoint inhibitors have emerged as an effective treatment for several tumor types and their use in clinical practice is expected to further increase in the immediate future. Although these agents are well tolerated, they are associated with a peculiar spectrum of toxicity, which is immune mediated and may potentially affect every organ. However, immune-related adverse events are mostly reversible if promptly diagnosed and adequately treated. Therefore, it is crucial that medical oncologists know how to diagnose and treat immune-related adverse events...
May 8, 2017: Tumori
https://www.readbyqxmd.com/read/28478644/the-role-of-mri-in-predicting-ki-67-in-breast-cancer-preliminary-results-from-a-prospective-study
#16
Corrado Caiazzo, Rosa Di Micco, Emanuela Esposito, Viviana Sollazzo, Maria Cervotti, Carlo Varelli, Pietro Forestieri, Gennaro Limite
PURPOSE: In the last decade contrast-enhanced magnetic resonance imaging (MRI) has gained a growing role as a complementary tool for breast cancer diagnosis. Currently the relationship between the kinetic features of a breast lesion and pathologic prognostic factors has become a popular field of research. Our aim is to verify whether breast MRI could be considered a useful tool to predict Ki-67 score, thus resulting as a breast cancer prognosis indicator. METHODS: From June to December 2014, we enrolled patients with breast cancer who underwent preoperative dynamic contrast-enhanced MRI at the local health agency...
April 28, 2017: Tumori
https://www.readbyqxmd.com/read/28478643/unmet-needs-of-italian-cancer-patients-in-different-stages-of-the-disease-and-care-process
#17
Andrea Bonacchi, Stefania Di Miceli, Donatella Lippi, Maria Grazia Muraca, Guido Miccinesi
PURPOSE: Assessing patients' unmet supportive care needs is essential in order to prioritize areas of cancer care that require improvement. The aim of the present cross-sectional study was to compare the unmet needs of cancer patients in different stages of the disease and care process (diagnosis, treatments following diagnosis, follow-up and/or rehabilitation, relapse/recurrence, progression of the disease, and palliative care). METHODS: The research focused on patients from 7 oncology units of the same geographic region (Tuscany, a region of central Italy) in the same period of time regardless of primary tumor site...
April 28, 2017: Tumori
https://www.readbyqxmd.com/read/28478642/fna-and-cnb-in-the-diagnosis-of-pulmonary-lesions-a-single-center-experience-on-665-patients-comparison-between-two-periods
#18
Alfonso Vittorio Marchianò, Maria Cosentino, Giuseppe Di Tolla, Francesca Gabriella Greco, Mario Silva, Nicola Sverzellati, Alessandra Fabbri, Elena Tamborini, Giuseppe Lo Russo, Luigi Mariani, Luca Lalli, Ugo Pastorino
PURPOSE: To evaluate the diagnostic yield and complication rate of 2 different biopsy techniques (fine-needle aspiration, FNA, and core-needle biopsy, CNB) in the diagnosis of pulmonary lesions in 2 distinct periods, 2010-2012 and 2013-2015. METHODS: We retrospectively analyzed the results of 691 CT-guided lung biopsies in 665 patients who were divided into 2 groups: cohort 1 (January 2010 to December 2012) was composed of 271 consecutive patients with 284 procedures either by FNA or CNB; cohort 2 (January 2013 to December 2015) was composed of 394 patients with 407 CNBs...
April 28, 2017: Tumori
https://www.readbyqxmd.com/read/28478645/a-supportive-care-in-cancer-unit-reduces-costs-and-hospitalizations-for-transfusions-in-a-comprehensive-cancer-center
#19
Carla Ida Ripamonti, Pietro Molani, Cinzia Desti, Giacomo Boscagli, Fernando Ravagnani, Flavio Arienti, Clementina Di Cristo
PURPOSE: Among patients with solid or hematologic malignancies undergoing oncologic therapies, blood product transfusions (BPT) are a relevant reason for planned/unplanned hospitalizations, as well as a possible cause of delay in administration of the oncologic therapies. Furthermore, they create additional costs for the healthcare system (HCS). The aim of this study was to compare the costs of performing BPT (erythrocytes and platelets) in medical units/wards to the costs derived from the administration of BPT in a dedicated outpatient supportive care in cancer unit (SCCU)...
April 24, 2017: Tumori
https://www.readbyqxmd.com/read/28430350/1st-evidence-based-italian-consensus-conference-on-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-carcinosis-from-ovarian-cancer
#20
Davide Cavaliere, Roberto Cirocchi, Federico Coccolini, Anna Fagotti, Massimiliano Fambrini, Orietta Federici, Domenica Lorusso, Marco Vaira, Marco Ceresoli, Paolo Delrio, Alfredo Garofalo, Sandro Pignata, Paolo Scollo, Vito Trojano, Andrea Amadori, Luca Ansaloni, Giuseppe Cariti, Franco De Cian, Pierandrea De Iaco, Michele De Simone, Marcello Deraco, Annibale Donini, Giammaria Fiorentini, Luigi Frigerio, Stefano Greggi, Antonio Macrì, Enrico Maria Pasqual, Franco Roviello, Paolo Sammartino, Cinzia Sassaroli, Giovanni Scambia, Carlo Staudacher, Patrizia Vici, Enrico Vizza, Mario Valle
Ovarian cancer (OC) remains relatively rare, although it is among the top 4 causes of cancer death for women younger than 50. The aggressive nature of the disease and its often late diagnosis with peritoneal involvement have an impact on prognosis. The current scientific literature presents ambiguous or uncertain indications for management of peritoneal carcinosis (PC) from OC, both owing to the lack of sufficient scientific data and their heterogeneity or lack of consistency. Therefore, the Italian Society of Surgical Oncology (SICO), the Italian Society of Obstetrics and Gynaecology, the Italian Association of Hospital Obstetricians and Gynaecologists, and the Italian Association of Medical Oncology conducted a multidisciplinary consensus conference (CC) on management of advanced OC presenting with PC during the SICO annual meeting in Naples, Italy, on September 10-11, 2015...
April 20, 2017: Tumori
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