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https://www.readbyqxmd.com/read/28315511/deletion-of-gstm1-and-gstt1-genes-and-lung-cancer-survival-a-systematic-review
#1
Cristina Ramos Hernández, Cecilia Mouronte-Roibás, Juan Miguel Barros-Dios, Alberto Fernández-Villar, Alberto Ruano-Ravina
PURPOSE: The mechanisms of lung carcinogenesis are not fully understood. Not all smokers develop lung cancer, indicating that genetic variations and other environmental factors may play an important role in its development. The human glutathione S-transferases (GSTs) have been associated with an increased risk of lung cancer. Glutathione S-transferases are phase II biotransformation enzymes that play a role in detoxifying a wide range of exogenous agents including carcinogens but also anticarcinogenic drugs...
March 18, 2017: Tumori
https://www.readbyqxmd.com/read/28315510/policies-for-reirradiation-of-recurrent-high-grade-gliomas-a-survey-among-italian-radiation-oncologists
#2
Carlo Furlan, Stefano Arcangeli, Michele Avanzo, Maria A Mirri, Fernando Munoz, Stefania Giudici, Antonio Perrone, Dante Amelio, Luigi Tomio, Loredana Draghini, Aniko M Deli, Giovanni Pavanato, Francesca M Giuliano, Antonio Pontoriero, Patrizia Ciammella, Pierina Navarria, Alberto Iannalfi, Michela Buglione, Cesare Guida, Silvia Cammelli, Vincenzo Iorio, Massimo Cardinali, Domenico Genovesi, Lucia Barsacchi, Mario Balducci, Rita Bagnoli, Franco Berti, Giampaolo Montesi, Francesco Pasqualetti, Paolo Bonome, Riccardo Santoni, Daniela Doino, Patrizia Schirru, Valentina Pinzi, Valentina Borzillo, Fabio Ferrarese, Marica Ferro, Luigi De Cicco, Marco Krengli, Silvia Scoccianti, Vittorio Donato
PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach...
March 18, 2017: Tumori
https://www.readbyqxmd.com/read/28315509/evaluation-of-late-cerebral-vascular-complications-in-cranially-irradiated-pediatric-cancer-patients-with-magnetic-resonance-angiography
#3
Serhan Kupeli, Kenan Bicakci, Gulay Sezgin, Ibrahim Bayram
BACKGROUND: We aimed to establish the early diagnosis of cerebral vascular complications by using cerebral magnetic resonance angiography (MRA) in patients who were treated with cranial RT in childhood as part of their cancer treatment. PROCEDURE: Patients who had received cranial RT before the age of 18 and had been in remission for at least 1 year were enrolled in the study. A data form including demographic and clinical characteristics and findings of cerebral MRA was filled in for each patient...
March 18, 2017: Tumori
https://www.readbyqxmd.com/read/28291905/long-term-results-of-therapy-with-sunitinib-in-metastatic-alveolar-soft-part-sarcoma
#4
Paulina Jagodzińska-Mucha, Tomasz Świtaj, Katarzyna Kozak, Hanna Koseła-Paterczyk, Anna Klimczak, Iwona Ługowska, Pawel Rogala, Michał Wągrodzki, Sławomir Falkowski, Piotr Rutkowski
BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare, highly vascularized soft tissue sarcoma characterized by a high frequency of metastatic disease and resistance to classical chemotherapy. The purpose of our analysis was to assess long-term sunitinib activity in the treatment of metastatic ASPS. PATIENTS AND METHODS: Between 2009 and 2015, 15 patients were diagnosed with metastatic ASPS and received therapy with sunitinib at initial continuous daily dosing of 37...
March 8, 2017: Tumori
https://www.readbyqxmd.com/read/28291904/perioperative-hdr-brachytherapy-for-reirradiation-in-head-and-neck-recurrences-single-institution-experience-and-systematic-review
#5
Luca Tagliaferri, Francesco Bussu, Bruno Fionda, Francesco Catucci, Mario Rigante, Maria Antonietta Gambacorta, Rosa Autorino, Gian Carlo Mattiucci, Francesco Miccichè, Elisa Placidi, Mario Balducci, Jacopo Galli, Gaetano Paludetti, György Kovacs, Vincenzo Valentini
AIM: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. MATERIALS AND METHODS: Patients treated with prior radiation doses >65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week...
March 8, 2017: Tumori
https://www.readbyqxmd.com/read/28291901/pet-ct-gamma-probe-guided-lymph-node-biopsy-a-new-diagnostic-surgical-approach
#6
Antonio Piñero-Madrona, Jorge Luis Monserrat-Coll, José Ruiz-Pardo, Juan Cabezas-Herrera, Francisco Nicolás-Ruiz
PURPOSE: The higher sensitivity of new diagnostic tools makes it easier to detect relapse in asymptomatic stages when classic procedures of lymph node biopsies are difficult to perform. The aim of this article is to describe the combination of gamma probe and 18F-FDG positron emission tomography-computed tomography (PET-CT) images in combination with sentinel lymph node biopsy technique for detection of nonpalpable lymph nodes. METHODS: After a dose of 18F-FDG was administered and PET-CT images that showed the location of suspected pathologic lymph nodes were obtained, transcutaneous localization of the lymph nodes with the highest captation of the tracer was done...
March 8, 2017: Tumori
https://www.readbyqxmd.com/read/28291902/review-of-the-mechanisms-involved-in-the-abscopal-effect-and-future-directions-with-a-focus-on-thymic-carcinoma
#7
Paul Lesueur, François Chevalier, Dinu Stefan, Jean-Louis Habrand, Delphine Lerouge, Radj Gervais
The abscopal effect is a rare phenomenon in radiotherapy, leading to impressive tumor regression outside the radiotherapy field. In this article we describe the occurrence of a postradiotherapy abscopal effect in an 89-year-old patient suffering from a metastatic neuroendocrine large-cell thymic carcinoma, the first case of the abscopal effect related to a thymic carcinoma reported in the literature. Along with the description of this case, we discuss and review the main potential mechanisms of bystander and abscopal effects in solid tumors so as to enable clinicians to identify and control these effects more resourcefully in the age of immunotherapy and stereotactic radiotherapy...
March 3, 2017: Tumori
https://www.readbyqxmd.com/read/28291907/the-effects-of-hyperthermic-intraperitoneal-chemoperfusion-on-colonic-anastomosis-an-experimental-study-in-a-rat-model
#8
Afag Aghayeva, Cigdem Benlice, Ismail Ahmet Bilgin, Pinar Atukeren, Gulen Dogusoy, Figen Demir, Deniz Atasoy, Bilgi Baca
INTRODUCTION: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28291906/changes-in-mortality-and-incidence-of-prostate-cancer-by-risk-class-in-different-periods-in-italy-the-possible-effects-of-psa-spread
#9
Massimo Vicentini, Claudio Sacchettini, Annalisa Trama, Nicola Nicolai, Gemma Gatta, Laura Botta, Riccardo Valdagni, Paolo Giorgi Rossi
PURPOSE: In Italy, the spread of prostate-specific antigen (PSA) testing varies in different areas. A peak of incidence was reached in 2003-2004 in some areas, while in others the incidence is still increasing. Mortality has declined since 1999 in some areas, while it remains stable in others. We compared mortality and the risk of advanced cancer over 2 periods (1996-1998; 2005-2007) and by geographic area characterized by a different spread of PSA, to understand the possible impact of PSA on the epidemiology of prostate cancer...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28291903/prostate-volume-index-stratified-prostate-cancer-risk-in-patients-elected-to-a-first-random-biopsy-set
#10
Antonio B Porcaro, Paolo Corsi, Nicolò de Luyk, Marco Sebben, Alessandro Tafuri, Leonardo Bizzotto, Giovanni Cacciamani, Davide De Marchi, Tania Processali, Daniele Mattevi, Giovanni Novella, Maria A Cerruto, Matteo Brunelli, Salvatore Siracusano, Walter Artibani
OBJECTIVE: To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set. METHODS: The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28233887/the-pathobiology-and-treatment-of-hodgkin-lymphoma-where-do-we-go-from-gianni-bonadonna-s-lesson
#11
Simonetta Viviani, Valentina Tabanelli, Stefano A Pileri
This article reviews the evolution of the diagnosis and treatment of Hodgkin lymphoma (HL) since its discovery in 1832. The morphological, phenotypic and molecular characteristics of both nodular lymphocyte-predominant HL and classical HL are revised in the light of recent molecular information and possible impact on the identification of risk groups as well as the use of targeted therapies. The seminal contribution of Gianni Bonadonna to developing new treatment strategies for both advanced and early-stage HL is highlighted...
February 22, 2017: Tumori
https://www.readbyqxmd.com/read/28218384/clinical-significance-of-circulating-tumor-cells-in-patients-with-small-cell-lung-cancer
#12
Yu-Li Wang, Chun-Hua Liu, Jing Li, Xiao-Ping Ma, Ping Gong
BACKGROUND: This study investigated the correlation of the presence of circulating tumor cells (CTCs) with clinical characteristics, and the predictive value of CTCs for progression-free survival (PFS) in patients with small-cell lung cancer (SCLC). METHODS: Samples were obtained from 42 patients with SCLC before and after the first cycle of chemotherapy. CTCs were quantitated by negative immunomagnetic enrichment and immunocytochemistry using anti-CD45 and anti-pancytokeratin antibodies...
February 15, 2017: Tumori
https://www.readbyqxmd.com/read/28218382/primary-cutaneous-non-hodgkin-lymphoma-results-of-a-retrospective-analysis-in-the-light-of-the-recent-ilrog-guidelines
#13
Sara Pedretti, Mauro Urpis, Carla Leali, Paolo Borghetti, Liliana Baushi, Raffaella Sala, Alessandra Tucci, Diana Greco, Nadia Pasinetti, Luca Triggiani, Giuseppe Rossi, Piergiacomo Calzavara-Pinton, Stefano Maria Magrini, Michela Buglione
PURPOSE: To analyze clinical outcome, local response, survival and toxicity in patients with primary cutaneous lymphoma (PCL) treated with radiotherapy. METHODS: From 1995 to 2014, 112 patients were treated. B-cell lymphomas (CBCLs; n = 86) and T-cell lymphomas (CTCLs; n = 23) were analyzed separately. Clinical and therapeutic characteristics (age, sex, histology, primary treatment and radiotherapy modality) were related to response to treatment, survival and toxicity...
February 14, 2017: Tumori
https://www.readbyqxmd.com/read/28218383/stereotactic-ablative-radiation-therapy-as-a-potential-curative-treatment-in-duodenal-adenocarcinoma-a-case-report
#14
Francesco Maria Aquilanti, Maria Cristina Barba, Federico Bianciardi, Barbara Tolu, Barbara Nardiello, Giorgio Hamid Raza, Randa El Gawhary, Chiara D'Ambrosio, PierCarlo Gentile
PURPOSE: One of the rarest gastrointestinal neoplasm is small bowel cancer. Experience with its treatment modalities is limited. Stereotactic ablative radiation therapy (SABR) has improved, with image-guided radiation therapy becoming a curative option in many tumors. Especially when surgery cannot be performed due to comorbidities, SABR provides a good toxicity profile and an excellent tumor control rate owing to its specific schedule: high dose on a limited and well-defined area. METHODS: An 83-year-old man had arterial hypertension and congestive cardiomyopathy, with recent history of upper abdominal pain, weight loss over 10 kg, and progressive severe fatigue...
February 11, 2017: Tumori
https://www.readbyqxmd.com/read/28218381/an-accurate-method-to-quantify-breathing-induced-prostate-motion-for-patients-implanted-with-electromagnetic-transponders
#15
Tommaso Giandini, Costanza M V Panaino, Barbara Avuzzi, Sara Morlino, Sergio Villa, Nice Bedini, Gabriele Carabelli, Sarah C Frasca, Anna Romanyukha, Anatoly Rosenfeld, Emanuele Pignoli, Riccardo Valdagni, Mauro Carrara
PURPOSE: To validate and apply a method for the quantification of breathing-induced prostate motion (BIPM) for patients treated with radiotherapy and implanted with electromagnetic transponders for prostate localization and tracking. METHODS: For the analysis of electromagnetic transponder signal, dedicated software was developed and validated with a programmable breathing simulator phantom. The software was then applied to 1,132 radiotherapy fractions of 30 patients treated in supine position, and to a further 61 fractions of 2 patients treated in prone position...
February 11, 2017: Tumori
https://www.readbyqxmd.com/read/28127742/performance-comparison-of-nextseq-and-ion-proton-platforms-for-molecular-diagnosis-of-clinical-oncology
#16
Fei Cao, Lianju Gao, Longgang Wei, Zhanni Chen, Yan Wang, Xia Ran, Xuehong Meng, Ji Tao
PURPOSE: Next-generation sequencing is a powerful approach to detect genetic mutations with which cancer diagnosis and treatment can be tailored to the individual patient in the era of personalized and precision medicine. Ion Torrent Systems Ion Proton and Illumina NextSeq are 2 major targeted sequencing platforms; however, not much work has been done to compare these platforms' performance for mutation detection in formalin-fixed paraffin-embedded (FFPE) materials. METHODS: We benchmarked the performance by using a collection of FFPE samples from 23 patients with different cancers for NextSeq and Ion Proton platforms...
January 25, 2017: Tumori
https://www.readbyqxmd.com/read/28127743/metachronous-solitary-metastasis-to-the-thyroid-gland-from-squamous-cell-carcinoma-of-the-lung-a-case-report-and-literature-review
#17
Francesco Gelsomino, Giuseppe Lamberti, Valentina Ambrosini, Francesca Sperandi, Roberto Agosti, Alessio G Morganti, Andrea Ardizzoni
INTRODUCTION: Non-small cell lung cancer presents at an advanced stage at diagnosis in two-thirds of cases. The most frequent metastatic sites are the central nervous system, adrenal glands and bones. By contrast, the thyroid gland is an extremely rare site of dissemination. CASE DESCRIPTION: A 64-year-old Caucasian man previously treated with radiosurgery and brain metastasectomy followed by right middle lobectomy for a squamous cell lung carcinoma had a metachronous solitary metastasis to the thyroid gland, as confirmed by fine-needle aspiration cytology and open biopsy...
January 23, 2017: Tumori
https://www.readbyqxmd.com/read/28106245/a-randomized-controlled-trial-of-mediterranean-diet-and-metformin-to-prevent-age-related-diseases-in-people-with-metabolic-syndrome
#18
Patrizia Pasanisi, Giuliana Gargano, Maria Gaetana Di Mauro, Mauro Cortellini, Alice Casagrande, Anna Villarini, Eleonora Bruno, Eliana Roveda, Gabriella Saibene, Elisabetta Venturelli, Franco Berrino
PURPOSE: Age-related non-communicable chronic diseases (ArCDs) are the leading cause of mortality. The major metabolic risk factor for their development is the metabolic syndrome (MetS), defined as a clustering of risk factors of metabolic origin such as abdominal obesity, high blood pressure, dyslipidemia and high fasting glycemia. There is increasing observational and experimental evidence that improving diet and the use of metformin (a calorie-restriction mimetic drug) may modify the risk of developing MetS and ArCD...
January 20, 2017: Tumori
https://www.readbyqxmd.com/read/28106246/patient-centered-medicine-in-palliative-cancer-care-the-impossible-choice-between-physician-s-responsibility-and-patient-s-preferences
#19
Elena Vegni, Lidia Borghi
No abstract text is available yet for this article.
January 16, 2017: Tumori
https://www.readbyqxmd.com/read/28106244/second-malignancy-risk-in-patients-with-bronchopulmonary-carcinoids-epidemiological-results-from-italian-network-of-cancer-registries
#20
Filippo Lococo, Carla Galeone, Claudio Sacchettini, Giovanni Leuzzi, Alfredo Cesario, Massimiliano Paci, Lucia Mangone
PURPOSE: This epidemiological study aimed to determine the prevalence and characteristics of second tumors (STs) in patients with bronchopulmonary carcinoids (BCs). METHODS: Data on neuroendocrine carcinomas (NECs) from the AIRTUM registry (1975-2011) were used for the analysis. Among 32,325 NECs, we focused our analysis on 3,205 patients (9.9%) affected by BCs. The overall ST number and incidence were calculated. The number of STs was compared with the expected cancer number in the healthy Italian population, and the standardized incidence ratio (SIR) and 95% confidence intervals were calculated...
January 16, 2017: Tumori
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