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Francesco Facchinetti, Francesca Bozzetti, Roberta Minari, Giovanni Ceccon, Teresa Zielli, Irene Florindo, Girolamo Crisi, Marcello Tiseo
INTRODUCTION: Treatment paradigms for EGFR-mutated non-small cell lung cancer (NSCLC) have successfully evolved since the introduction of osimertinib. The detection of EGFR T790M mutation in plasma or tumor samples obtained at disease progression to first-/second-generation EGFR inhibitors is mandatory for osimertinib prescription. Nevertheless, pharmacokinetics properties of osimertinib guarantee its usefulness in central nervous system (CNS) disease even in the case of T790M-negative or unknown status...
November 5, 2018: Tumori
Laura Veneroni, Paola Gaggiotti, Davide Ciceri, Edoardo Rosati, Maura Massimino, Andrea Ferrari
No abstract text is available yet for this article.
October 24, 2018: Tumori
Davide Facchinelli, Enrico Boninsegna, Marco Barillari, Giancarlo Mansueto, Mauro Krampera, Dino Veneri
Primary lymphoma of the sphenoid is an extremely rare pathology, therefore it is difficult to hypothesize and the imaging characteristics are not well-known. Here we report the imaging features in computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scan of a 44-year-old patient who presented with severe headache. CT and MRI showed a sphenoid sinus mass that suggested rhinopharyngeal lesion or a chordoma. However, biopsy from the mass histologically proved it to be Diffuse large B-cell lymphoma and PET examinations revealed increased fluorodeoxyglucose uptake around the sphenoid bone and multiple spinal lesions...
October 1, 2018: Tumori
Andrea Bonacchi, Eleonora Fazzini, Silvia Messina, Maria Grazia Muraca, Paola Pacetti, Stefania Di Miceli, Guido Miccinesi
PURPOSE: Although an optimal goal remains the routine assessment of unmet needs of all patients with cancer, particular attention should be paid to those groups of patients with characteristics known to be more frequently associated with unmet needs in general or with specific areas of need. This report aims to describe the sociodemographic, clinical, and psychological characteristics associated with higher unmet needs in Italian cancer patients. METHODS: A total of 835 cancer patients from different care settings (ward, day hospital, follow-up ambulatory, rehabilitation unit, and palliative care) filled out the Needs Evaluation Questionnaire (NEQ), the Psychological Distress Inventory, and the Sense of Coherence Scale...
September 5, 2018: Tumori
Ulrich Ronellenfitsch, Kristina Ernst, Christina Mertens, Marcus J Trunk, Philipp Ströbel, Alexander Marx, Peter Kienle, Stefan Post, Kai Nowak
INTRODUCTION: Survival in gastric cancer is often limited by peritoneal carcinomatosis, which supposedly develops from serosal tumor infiltration or tumor cell spread during gastrectomy with lymphadenectomy. To eliminate peritoneal tumor cells, extensive intraperitoneal lavage (EIPL) has been suggested. Impressive results have been achieved in Japanese trials. In this trial, we assessed EIPL in Western patients. METHODS: This prospective trial included patients with non-metastatic gastric adenocarcinoma undergoing gastrectomy with D2 lymphadenectomy...
September 5, 2018: Tumori
Serhan Tanju, Suat Erus, Fatih Selçukbiricik, Sinem İliaz, Murat Kapdağlı, Pınar Bulutay, Tolga Evrim Sevinç, Nil Molinas Mandel, Şükrü Dilege
OBJECTIVE: To analyze the extent of visceral pleural invasion (VPI) and its effect on survival along with its place in determining the T descriptor in TNM staging in our patients. METHODS: A total of 233 patients underwent lung resection. The data were retrospectively analyzed in terms of sex, age, histopathologic type, stage of the tumor, extent of VPI, and survival. Patients who had neoadjuvant chemotherapy or chemoradiotherapy, distant metastasis, parietal pleural invasion, and operative mortality were excluded...
August 30, 2018: Tumori
Baoyu Yang, Chunmei Shi, Xiaoyan Lin, Xinli Wang, Qiang Chen
PURPOSE: To investigate the efficacy of paclitaxel combined with a leucovorin and 5-fluorouracil regimen (PLF regimen; q2w) as neoadjuvant chemotherapy (NCT) for advanced gastric cancer. METHODS: A total of 183 patients with advanced gastric cancer who underwent 3 cycles of PLF regimen chemotherapy before surgery and received surgery 2 weeks after chemotherapy were enrolled as a treatment group. A total of 184 patients with advanced gastric cancer and no NCT during the same period were enrolled as the controls and treated with surgery...
August 29, 2018: Tumori
Arthur Streit, Francesco Guerrera, Matthieu Kouki, Joelle Siat, Paraskevas Lyberis, Pier Luigi Filosso, Stéphane Renaud
INTRODUCTION: Pseudochylothorax is a rare cause of pleural effusion. Sometimes confounded with chylothorax, firm diagnosis relies on analysis of the pleural liquid: exudative liquid (protein >30 g/L, lactate dehydrogenase >200 UI/L) with a high level of cholesterol (usually >200 mg/dL), low level of triglyceride (usually <110 mg/dL), cholesterol total/triglyceride ratio >1, absence of chylomicron, and in some cases the presence of cholesterol crystals. Pseudochylothorax is secondary to tuberculosis and rheumatoid arthritis in nearly 90% of cases...
August 29, 2018: Tumori
Raffaella Cioffi, Alice Bergamini, Emanuela Rabaiotti, Micaela Petrone, Francesca Pella, Davide Ferrari, Giorgia Mangili, Massimo Candiani
OBJECTIVE: To review a single-center clinical experience with neoadjuvant chemotherapy (NACT) in a population of frail epithelial ovarian cancer (EOC) patients and investigate the prognostic role of advanced age. METHODS: We retrospectively reviewed clinical data from 102 advanced EOC patients treated with NACT and presenting high perioperative risk. Patients were divided into 2 groups: group A, including patients aged 70 years or older; and group B, including patients below 70 years old...
August 29, 2018: Tumori
Domenico C Corsi, Adriana Turriziani, Luigi Cavanna, Piero Morino, Angela S Ribecco, Marco Ciaparrone, Gaetano Lanzetta, Carmine Pinto, Vittorina Zagonel
A consensus document on early palliative care was produced by a committed Working Group of the Italian Society of Medical Oncology and the Italian Society of Palliative Care to improve the early integration of palliative care in medical oncology and to stimulate and guide the choices of those who daily face the problems of advanced stage cancer patients. The simultaneous administration of antineoplastic treatments and early palliative care was shown to be beneficial in metastatic cancer pathway outcomes. Patients who could benefit from early palliative care are those with an advanced cancer at presentation, a compromised PS for cancer, and/or morbidities, and who are too frail to receive treatment...
August 29, 2018: Tumori
Mariacarla Valli, Simona Cima, Paola Fanti, Barbara Muoio, Alessandra Vanetti, Che N Azinwi, Kaloyan Yordanov, Francesco Martucci, Gianfranco A Pesce, Claudia Canonica, Antonella Richetti
OBJECTIVE: To analyze the impact of adjuvant radiotherapy (RT) on ipsilateral breast recurrence (IBR) and overall survival (OS) in patients older than 69 years with early-stage breast cancer. METHODS: From January 2007 to June 2015, we analyzed retrospectively 137 women with estrogen receptor-positive T1-2 invasive breast cancer, with negative axillary lymph nodes, dividing them into 2 subgroups: 70 to 79 years and older than 79 years. RESULTS: After a median follow-up of 43...
August 27, 2018: Tumori
Maurizio Mascarin, Andrea Ferrari
Cancer can erupt in an adolescent's life, damaging his or her multidimensional balance with its burden of physical suffering, changes in appearance, and anxiety, interrupting their activities, keeping them away from school, and isolating them socially. It is crucially important for adolescents with cancer to be able to feel the same as before, to feel they belong to a group of schoolmates. This is not always easy to achieve. Their peers sometimes lack the necessary resources to treat adolescents with cancer as normal ones, responding instead with pity or avoidance...
August 22, 2018: Tumori
Pierina Navarria, Federico Pessina, Luca Cozzi, Stefano Tomatis, Giacomo Reggiori, Matteo Simonelli, Armando Santoro, Elena Clerici, Ciro Franzese, Giulio Carta, Marco Conti Nibali, Lorenzo Bello, Marta Scorsetti
OBJECTIVE: To evaluate hypofractionated radiation therapy (HFRT) given at therapeutic effective doses in a phase II study. Endpoints were progression-free survival (PFS) rate, overall survival (OS), and incidence of toxicity. METHODS: Patients with newly diagnosed glioblastoma, age ⩾70 years, Karnofsky performance scale (KPS) score ⩽60, were enrolled. The total dose of HFRT was 52.5 Gy/15 fractions, corresponded to a biological effective dose to the tumor of 70...
August 22, 2018: Tumori
Alessia Compostella, Maria Carmen Affinita, Michela Casanova, Giuseppe Maria Milano, Angela Scagnellato, Patrizia Dall'Igna, Stefano Chiaravalli, Marta Pierobon, Carla Manzitti, Ilaria Zanetti, Amalia Schiavetti, Silvia Sorbara, Rosella Maria Mura, Antonio Ruggiero, Andrea Ferrari, Gianni Bisogno
INTRODUCTION: From 2002 to 2011, the Italian Soft Tissue Sarcoma Committee explored a combination of topotecan and carboplatin as a second-line strategy for children with resistant or relapsing rhabdomyosarcoma. METHODS: Patients received two blocks of topotecan 2 mg/m2 on days 1, 2, and 3, and carboplatin 250 mg/m2 on days 4 and 5, followed by alternating blocks of topotecan-cyclophosphamide and carboplatin-etoposide for a total of six courses with 3-week intervals...
August 22, 2018: Tumori
Stefano Signoroni, Maria Grazia Tibiletti, Maria Teresa Ricci, Massimo Milione, Federica Perrone, Valeria Pensotti, Anna Maria Chiaravalli, Ileana Carnevali, Alberto Morabito, Lucio Bertario, Marco Vitellaro
OBJECTIVE: To investigate the performance of tumor testing approaches in the identification of Lynch syndrome (LS) in a single-center cohort of people with colorectal cancer (CRC). METHODS: A retrospective analysis of data stored in a dedicated database was carried out to identify patients with CRC suspected for LS who were referred to Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, between 1999 and 2014. The sensitivity and specificity of immunohistochemistry (IHC) for mismatch repair (MMR) proteins and microsatellite instability (MSI) analysis (alone or combined) were calculated with respect to the presence of causative MMR germline variants...
August 17, 2018: Tumori
Paola Gaggiotti, Laura Veneroni, Stefano Signoroni, Matteo Silva, Marco Chisari, Michela Casanova, Stefano Chiaravalli, Giovanna Sironi, Carlo Alfredo Clerici, Tullio Proserpio, Maura Massimino, Andrea Ferrari
INTRODUCTION: Adolescents diagnosed with cancer have to temporarily stop pursuing several vital needs and making plans for the future. The Youth Project in Milan, Italy, focuses on such issues in young cancer patients' personal lives. Uncertainty about the future had already emerged in several artistic projects designed to help these patients voice their emotions. METHODS: We describe a project revolving around the question "What shall I do when I grow up?" Twenty-seven 15- to 26-year-old patients wrote a brief account of what they hoped to do as adults...
August 17, 2018: Tumori
Lupe Sanchez-Mete, Vittoria Stigliano
Despite its rarity in the general population, small bowel adenocarcinoma risk is increased in individuals with hereditary colorectal cancer syndromes (HCCS). In the last decade, the advent of capsule endoscopy and device-assisted balloon enteroscopy procedures in patients with HCCS have allowed to investigate the whole small bowel, increasing the diagnostic yield of small bowel tumor. Nonetheless, there is a significant variability in the international guideline recommendations. The aim of this review is to provide an update on surveillance of small bowel in HCCS and to identify the key points for the clinical management of these patients...
August 17, 2018: Tumori
Tae Gyu Kim, Won Park, Hakyoung Kim, Doo Ho Choi, Hee Chul Park, Seok-Hyung Kim, Yong Beom Cho, Seong Hyen Yun, Hee Cheol Kim, Woo Yong Lee, Jeeyun Lee, Ki Mun Kang
PURPOSE: There is uncertainty over the effect of systemic inflammatory response on oncologic outcomes in patients who underwent neoadjuvant chemoradiotherapy and surgery for rectal cancer. We investigated the association between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as markers of systemic inflammation and tumor response and prognosis after treatment. METHODS: A total of 176 patients who underwent neoadjuvant chemoradiotherapy and curative surgery for rectal cancer were analyzed retrospectively...
August 17, 2018: Tumori
Norbert Maggi, Roberta Gazzarata, Carmelina Ruggiero, Claudio Lombardo, Mauro Giacomini
INTRODUCTION: This article focuses on the integration of omics data in electronic health records and on interoperability aspects relating to big data analysis for precision medicine. METHODS: Omics data integration methods for electronic health record and for systems interoperability are considered, with special reference to the high number of specific software tools used to manage different aspects of patient treatment. This is an important barrier against the use of this integrated approach in daily clinical routine...
August 17, 2018: Tumori
Emanuela Palmerini, Pietro Ruggieri, Andrea Angelini, Stefano Boriani, Domenico Campanacci, Giuseppe M Milano, Marilena Cesari, Anna Paioli, Alessandra Longhi, Massimo E Abate, Guido Scoccianti, Silvia Terzi, Giulia Trovarelli, Alessandro Franchi, Piero Picci, Stefano Ferrari
PURPOSE: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities with giant cell tumor of bone (GCTB), denosumab was active also in ABC. METHODS: In this observational study, a retrospective analysis of ABC patients treated with denosumab was performed. Patients underwent radiologic disease assessment every 3 months. Symptoms and adverse events were noted. RESULTS: Nine patients were identified (6 male, 3 female), with a median age of 17 years (range 14-42 years)...
August 8, 2018: Tumori
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