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Hassan Yousefi, Majid Momeny, Seyed H Ghaffari, Nazanin Parsanejad, Arash Poursheikhani, Sepehr Javadikooshesh, Ghazaleh Zarrinrad, Fatemeh Esmaeili, Zivar Alishahi, Zahra Sabourinejad, Ghazaleh Sankanian, Sahar Shamsaiegahkani, Davood Bashash, Narjes Shahsavani, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
INTRODUCTION: Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide and despite an initial response to therapeutic agents, the majority of patients have chemoresistant disease. There is no treatment strategy with proven efficacy against chemoresistant EOC and in this setting, overcoming therapy resistance is the key to successful treatment. METHODS: This study aimed to investigate expression of interleukin-6 (IL-6) (IL-6) and IL-6 receptor (IL-6R) in a panel of the EOC cell lines...
July 1, 2018: Tumori
Carla Moscheo, Alessandro Campari, Marta Giorgia Podda, Giovanna Riccipetitoni, Paola Collini, Salvatore Lorenzo Renne, Claudio Vella, Marcello Napolitano, Roberto Luksch
INTRODUCTION: Peripheral neuroblastic tumors (PNTs) account for 8%-10% of all pediatric tumors. Adrenal glands and sympathetic ganglia are the commonest site of tumor growth. In the clinicopathologic spectrum of PNTs, neuroblastoma and ganglioneuroma are the most primitive and the most mature tumor form, while ganglioneuroblastoma represents an intermediate state of maturation. Surgical resection is the therapy of choice in localized disease, but can lead to serious complications when performed in the presence of certain imaging-defined risk factors...
July 1, 2018: Tumori
Mauro F Palazzi, Carlo Soatti, Barbara A Jereczek-Fossa, Luigi F Cazzaniga, Paolo Antognoni, Gianstefano Gardani, Marcello Amadori, Ambrogia Baio, Giancarlo Beltramo, Mario Bignardi, Stefano Bracelli, Alberto Buffoli, Simona Castiglioni, Gianpiero Catalano, Nadia Di Muzio, Carlo Fallai, Laura Fariselli, Paolo Frata, Alberto Gramaglia, Corrado Italia, Giovanni Ivaldi, Fabrizio Lombardi, Stefano M Magrini, Simonetta Nava, Enrico Sarti, Luciano Scandolaro, Marta Scorsetti, Francesco Stiglich, Roberto Tortini, Riccardo Valdagni, Francesca Valvo, Vittorio Vavassori, Elena L Sbicego, Sandro Tonoli, Roberto Orecchia
INTRODUCTION: Several efforts are being implemented at the European level to measure provision of up-to-date radiation treatments across the continent. METHODS: A snapshot survey involving all radiation oncology centers within Lombardy, Italy, was performed in 2012 and repeated in 2014 and 2016, in cooperation with regional governmental officers. Centers were asked to provide detailed information concerning all individual patients being treated on the index day, and to report data on available local resources...
July 1, 2018: Tumori
Christophe Tourasse, Elina Khasanova, Philippe Sebag, Jean Paul Beregi
OBJECTIVE: In this study, we aimed to analyze technical and diagnostic potential, and safety of the small-caliber vacuum-assisted biopsy (SCVAB) device in a multicenter consecutive study taking into consideration the type and location of breast lesion. METHODS: We collected data from 5 breast imaging centers where radiologists used the SCVAB device for biopsies in 162 patients. We analyzed the conditions for using the SCVAB device according to the characteristics of the lesions, the volume of excision, and the analyzability obtained by biopsy samples...
July 1, 2018: Tumori
Giorgio Bogani, Antonino Ditto, Umberto Leone Roberti Maggiore, Cono Scaffa, Lavinia Mosca, Valentina Chiappa, Fabio Martinelli, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To test the safety and effectiveness of neoadjuvant chemotherapy followed by interval debulking surgery in unresectable stage IVB serous endometrial cancer. METHODS: Data of consecutive stage IVB serous endometrial cancer are reviewed. Patients undergoing neoadjuvant chemotherapy plus interval debulking surgery were propensity matched with patients undergoing primary surgery followed by adjuvant treatment. RESULTS: Thirty-four patients were diagnosed with a stage IVB endometrial cancer...
July 1, 2018: Tumori
Tiziana Magnani, Sergio Bracarda, Rolando M D'Angelillo, Walter Artibani, Sandro Barni, Giordano Beretta, Maurizio Brausi, Orazio Caffo, Renzo Corvò, Michele Gallucci, Roberta Gunelli, Vincenzo Mirone, Giacomo Novara, Carmine Pinto, Elvio Russi, Riccardo Santoni, Maurizio Tomirotti, Alessandro Volpe, Giario Conti, Riccardo Valdagni
INTRODUCTION: The multidisciplinary management of oncologic patients is identified as the bottom line element of quality in tumor care. METHODS: In 2015, 7 Italian scientific societies representing the specialists involved in the diagnosis and treatment of genitourinary tumors joined efforts in the Italian uro-oncologic multidisciplinary teams (MDTs) project. The aims were to promote the reorganization of genitourinary cancer care, switching to a multidisciplinary approach, reach a consensus on the core elements for the setup of MDTs in genitourinary oncology, and support health policy makers and managers in remodeling of the assistance and care of uro-oncologic patients on a national level...
July 1, 2018: Tumori
Luca Ampollini, Luigi Ventura, Letizia Gnetti, Paolo Carbognani, Enrico Maria Silini, Michele Rusca
PURPOSE: To describe a case of giant intercostal nerve schwannoma successfully resected in a patient with neurofibromatosis type 2. METHODS: A 44-year-old woman, with a history of neurofibromatosis type 2, presented with chest discomfort and mild dyspnea. She had undergone a recent resection of a large frontal parasagittal benign meningioma. Radiologic examinations showed a large lesion (9×12×9 cm) of the left hemithorax causing a complete atelectasis of left upper lobe...
June 1, 2018: Tumori
Thierry Philip, Geneviève Almouzni, Philip Poortmans
INTRODUCTION: A mission-oriented approach to cancer care in Europe was proposed by Julio Celis and Dainius Pavalkis in 2017. The major proposed objective is to achieve long-term survival of 3 out of 4 cancer patients by 2030. BACKGROUND: The authors are president or president-elect of Organization of European Cancer Institutes (OECI) EU Life or European Cancer Community Organization (ECCO). RESULTS: The goal is laudable and ambitious. However, it can only be successful if it is coordinated with active involvement of all stakeholders and interacts with an already well-organized, recognized, and certified European Accreditation and Designation quality approach to identify and select the potential candidates to participate in such a virtual network...
June 1, 2018: Tumori
Francesca Mazzoni, Paolo Petreni, Marco Perna, Vieri Scotti, Stefano Bongiolatti, Lorenzo Livi, Francesco Di Costanzo, Luca Voltolini
Afatinib, a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is effective as first-line treatment in patients with EGFR-mutated non-small cell lung cancer (NSCLC). We report 2 cases of EGFR-mutated locally advanced NSCLC treated in neoadjuvant setting with EGFR tyrosine kinase inhibitor at University of Florence/Careggi Hospital. In both cases, afatinib was used for up to 3 months, until 1 week before surgery. Both patients achieved significant reduction (downstaging) of the pulmonary mass and lymphadenopathies and after surgery, it was decided for both cases to restore afatinib treatment up to a further 4 months...
June 1, 2018: Tumori
Andrea Sbrana, Andrea Antonuzzo, Luca Galli, Elisa Biasco, Gianna Musettini, Federico Paolieri, Sergio Ricci
INTRODUCTION: Basal cell carcinoma (BCC) is the most common skin cancer. Treatment options for metastatic or locally advanced BCC inappropriate for surgery or radiotherapy were poor until vismodegib was approved for use in this setting. This drug can be safely used in patients with mild to moderate renal impairment, but limited data are available for its use in case of severe kidney failure. We present the case of a patient with severe renal failure on hemodialysis treated with vismodegib...
June 1, 2018: Tumori
Carlo Resteghini, Federica Perrone, Rosalba Miceli, Cristiana Bergamini, Salvatore Alfieri, Ester Orlandi, Marco Guzzo, Roberta Granata, Donata Galbiati, Stefano Cavalieri, Laura Locati, Lisa Licitra, Bossi Paolo
BACKGROUND: Human papilloma virus (HPV)-negative oropharyngeal squamous cell carcinomas (OPCs) have a poorer prognosis and best management is an unmet need. We studied the prognostic role of epidermal growth factor receptor (EGFR) and PIK3CA amplifications and TP53 functional status. METHODS: Between 1992 and 2000, 90 consecutive patients with OPCs were treated with surgery, followed by radiotherapy in case of high-risk pathologic features. Of those, 73 cases were HPV-negative and therefore were selected for molecular analysis ( PIK3CA and EGFR fluorescent in situ hybridization [FISH] analysis and TP53 mutation analysis)...
April 1, 2018: Tumori
Piotr Rutkowski, Paweł Teterycz, Anna Klimczak, Elżbieta Bylina, Katarzyna Szamotulska, Iwona Lugowska
INTRODUCTION: Neutrophil-to-lymphocyte ratio (NLR) was shown to be prognostic in several solid malignancies. There are limited data about predictive/prognostic value of NLR during targeted therapy of patients with advanced gastrointestinal stromal tumors (GIST). The aim of this study was to asses a clinical value of this ratio in patients with advanced GIST. METHODS: Between 2001 and 2016, 385 patients with metastatic/unresectable GIST treated initially with imatinib were included in the analysis...
April 1, 2018: Tumori
Giuseppe Boni, Sara Mazzarri, Claudia Cianci, Luca Galli, Azzurra Farnesi, Eugenio Borsatti, Roberto Bortolus, Lucia Fratino, Carlo Gobitti, Elda Lamaj, Pietro Ghedini, Elisa Lodi Rizzini, Francesco Massari, Valeria Dionisi, Stefano Fanti, Duccio Volterrani, Fabio Monari
BACKGROUND: Radium-223 (223 Ra) chloride, an alpha emitter, has been shown to improve overall survival (OS) and pain control, and to delay skeletal-related events, in patients with castration-resistant prostate cancer (CRPC) and bone metastases. Our retrospective observational study presents the first Italian experience on the efficacy and safety of 223 Ra therapy in routine clinical practice. METHODS: A total of 83 patients with metastatic CRPC were treated with 223 Ra at 3 Italian centers between August 2013 and August 2016...
April 1, 2018: Tumori
Kita Sallabanda, Hernan Barrientos, Daniela Angelina Isernia Romero, Cristian Vargas, Jose Angel Gutierrez Diaz, Carmen Peraza, Eleonor Rivin Del Campo, Juan Manuel Praena-Fernandez, José Luis López-Guerra
AIMS AND BACKGROUND: The treatment of glomus jugulare tumors (GJT) remains controversial due to high morbidity. Historically, these tumors have primarily been managed surgically. The purpose of this retrospective review was to assess the tumor and clinical control rates as well as long-term toxicity of GJT treated with radiosurgery. METHODS: Between 1993 and 2014, 30 patients with GJT (31 tumors) were managed with radiosurgery. Twenty-one patients were female and the median age was 59 years...
April 1, 2018: Tumori
Martina Ferrari, Carla I Ripamonti, Nicholas J Hulbert-Williams, Guido Miccinesi
INTRODUCTION: In oncology settings, less attention is given to patients' unmet needs and to existential and emotional distress compared to physical symptoms. We aimed to evaluate correlations between unmet needs and emotional distress (self-reported anxiety and depression) in a consecutive cohort of cancer patients. The influence of sociodemographic and clinical factors was also considered. METHODS: A total of 300 patients with cancer recruited from an outpatient Supportive Care Unit of a Comprehensive Cancer Centre completed the Need Evaluation Questionnaire and the Edmonton Symptom Assessment System (ESAS)...
April 1, 2018: Tumori
Filippo Alongi, Rosario Mazzola, Vanessa Figlia, Matthias Guckenberger
Exhaustive criteria and definitive data to identify the ideal lung oligometastatic patient as a candidate for stereotactic body radiotherapy (SBRT) are lacking. Three distinct cohorts of oligometastatic patients could be distinguished: (1) patients with upfront diagnosis of oligometastases (synchronous or metachronous); (2) patients with oligorecurrent disease in terms of relapsed oligometastatic phase; (3) oligoprogressive patients after cytoreductive treatment. The aim of the present review is to analyze available data concerning the efficacy/safety of SBRT for oligometastatic/oligoprogressive/oligorecurrent lung metastases...
April 1, 2018: Tumori
Kisoo Pahk, Jae Ho Chung, Sungeun Kim, Sung Ho Lee
AIMS AND BACKGROUND: Distinction between primary lung adenocarcinoma and metastatic adenocarcinoma from extrapulmonary origin in solitary pulmonary nodule (SPN) is crucial for cancer treatment. We investigated the predictive role of dual-time-point 18 F-FDG PET/CT to distinguish primary and metastatic lung adenocarcinoma in SPN. METHODS: A total of 96 consecutive patients with newly diagnosed SPN and biopsy-proven adenocarcinoma were enrolled in this study, retrospectively (54 male; 42 female; age 59...
April 1, 2018: Tumori
Consuelo Rosa, Monica Di Tommaso, Luciana Caravatta, Annamaria Vinciguerra, Antonietta Augurio, Francesca Perrotti, Albina Allajbej, Marco Regoli, Isaia Al Zecca, Marta Di Nicola, Domenico Genovesi
PURPOSE: To report long-term effects on anorectal function and bowel disorders and late toxicity rate of preoperative chemoradiotherapy in patients with locally advanced rectal cancer. METHODS: Between 2000 and 2016, 201 patients treated with different neoadjuvant schedules of chemotherapy and radiotherapy doses were retrospectively analyzed. The Memorial Sloan-Kettering Cancer Center score was used for the evaluation of anal sphincter function. RESULTS: The median follow-up time was 68 months (interquartile range 35-113 months)...
April 1, 2018: Tumori
Daniela Greto, Mauro Loi, Calogero Saieva, Cristina Muntoni, Camilla Delli Paoli, Carlotta Becherini, Cinzia Ciabatti, Marco Perna, Domenico Campanacci, Francesca Terziani, Giovanni Beltrami, Guido Scoccianti, Pierluigi Bonomo, Icro Meattini, Isacco Desideri, Gabriele Simontacchi, Monica Mangoni, Lorenzo Livi
INTRODUCTION: This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment of soft tissue sarcoma (STS). METHODS: A total of 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed in high-risk patients. Acute radiotherapy toxicity and chemotherapy-related toxicity were assessed according to the Common Terminology Criteria for Adverse Events 4.0; late radiotherapy toxicity was recorded according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria...
April 1, 2018: Tumori
Hui Zhang, Wei Liu, Zhi Wang, Lin Meng, Yunhua Wang, Huawu Yan, Lin Li
INTRODUCTION: Mitogen-inducible gene 6 ( MIG6) holds a special position in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance. As MIG6 regulates the activity of EGFR signal pathway negatively, high level of MIG6 can increase the EGFR TKI resistance of cancer cells, and limit the therapeutic action of EGFR TKI, such as gefitinib or erlotinib. Therefore, better understanding of the molecular mechanisms underlying the regulation of EGFR TKI resistance holds great value in cancer therapy...
April 1, 2018: Tumori
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