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Caries Research

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https://www.readbyqxmd.com/read/28445870/klk4-gene-and-dental-decay-replication-in-a-south-brazilian-population
#1
Tayla Cavallari, Simone Tetu Moyses, Samuel Jorge Moyses, Renata Iani Werneck
OBJECTIVE: The objective of this research was to identify and replicate the participation of KLK4 gene polymorphisms in the susceptibility to dental decay. METHODS: A total of 200 patients were recruited using ICDAS criteria - 100 of them with dental caries and 100 with no history of the disease. Buccal cells were collected and the DNA was extracted and amplified using PCR. RESULTS: During the descriptive analysis, the variables ethnicity, biofilm, and gingivitis and the markers rs2242670 and rs2978642 were statistically significant...
April 27, 2017: Caries Research
https://www.readbyqxmd.com/read/28395292/genes-involved-in-the-enamel-development-are-associated-with-calcium-and-phosphorus-level-in-saliva
#2
Erika Calvano Küchler, Giovana Daniela Pecharki, Myrella Lescio Castro, Junia Ramos, Fernando Barbosa, João Armando Brancher, Alexandre Rezende Vieira, Raquel Fernanda Gerlach, Paula Cristina Trevilatto
Saliva components play a crucial role in the integrity of the dental enamel and in caries susceptibility. The saliva characteristics are controlled by many factors, including genetic factors. Therefore, this study aimed to evaluate the association between the genetic variations in genes expressed in enamel development with calcium and phosphorus levels in saliva. We collected 276 unrelated 12-year-old children from private and public schools. Saliva was collected for DNA extraction from oral cells and for measurement of calcium and phosphorus...
April 11, 2017: Caries Research
https://www.readbyqxmd.com/read/28391272/in-office-application-of-fluoride-gel-or-varnish-cost-effectiveness-and-expected-value-of-perfect-information-analysis
#3
Falk Schwendicke, Michael Stolpe
Application of fluoride gel/varnish (FG/FV) reduces caries increments but generates costs. Avoiding restorative treatments by preventing caries might compensate for these costs. We assessed the cost-effectiveness of dentists applying FG/FV in office and the expected value of perfect information (EVPI). EVPI analyses estimate the economic value of having perfect knowledge, assisting research resource allocation. A mixed public-private-payer perspective in Germany was adopted. A population of 12-year-olds was followed over their lifetime, with caries increments modelled using wide intervals to reflect the uncertainty of caries risk...
April 8, 2017: Caries Research
https://www.readbyqxmd.com/read/28359051/postradiation-matrix-metalloproteinase-20-expression-and-its-impact-on-dental-micromorphology-and-radiation-related-caries
#4
Wagner Gomes-Silva, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Karina Morais-Faria, Gilberto de Castro Junior, Milena Perez Mak, Marcio Ajudarte Lopes, Marcelo Marques Rocha, Tuula Salo, Leo Tjäderhane, Mario Fernando de Goes, Alan Roger Santos-Silva
Recent evidence suggests that head-and-neck radiotherapy (HNRT) increases active forms of matrix metalloproteinase-20 (MMP-20) in human tooth crowns, degrading the dentin-enamel junction (DEJ) and leading to enamel delamination, which is a pivotal step in the formation of radiation-related caries (RRC). Additional participation of enzymatic degradation of organic matrix components in caries progression was attributed to MMP-20 in dentin. Therefore, the current study tested the hypothesis that MMP-20 is overexpressed in the DEJ, dentin-pulp complex components, and carious dentin of post-HNRT patients, leading to detectable micromorphological changes to the enamel and dentin...
March 31, 2017: Caries Research
https://www.readbyqxmd.com/read/28343232/genetic-polymorphisms-in-defb1-and-mirna202-are-involved-in-salivary-human-%C3%AE-defensin-1-levels-and-caries-experience-in-children
#5
Andrea Lips, Leonardo Santos Antunes, Lívia Azeredo Antunes, Júlia Guimarães Barcellos de Abreu, Driely Barreiros, Daniela Silva Barroso de Oliveira, Ana Carolina Batista, Paulo Nelson-Filho, Léa Assed Bezerra da Silva, Raquel Assed Bezerra da Silva, Gutemberg Gomes Alves, Erika Calvano Küchler
The antimicrobial peptides human β-defensins (hBDs) are encoded by β-defensin genes (DEFBs) and are possibly involved in caries susceptibility. In this study we aimed (1) to investigate the relationship between salivary hBDs and caries and (2) to evaluate the association of genetic polymorphisms in DEFB1 and microRNA202 (miRNA202) with salivary levels of hBDs and caries experience. Two data sets were available for this study, totalizing 678 Brazilian children. Dental examination and saliva collection were performed in all included children...
March 25, 2017: Caries Research
https://www.readbyqxmd.com/read/28291962/matching-the-statistical-model-to-the-research-question-for-dental-caries-indices-with-many-zero-counts
#6
John S Preisser, D Leann Long, John W Stamm
Marginalized zero-inflated count regression models have recently been introduced for the statistical analysis of dental caries indices and other zero-inflated count data as alternatives to traditional zero-inflated and hurdle models. Unlike the standard approaches, the marginalized models directly estimate overall exposure or treatment effects by relating covariates to the marginal mean count. This article discusses model interpretation and model class choice according to the research question being addressed in caries research...
March 15, 2017: Caries Research
https://www.readbyqxmd.com/read/28245470/evidence-of-an-in-vitro-coupled-diffusion-mechanism-of-lesion-formation-within-microcosm-dental-plaque
#7
Gareth J Owens, Richard J M Lynch, Christopher K Hope, Lee Cooper, Susan M Higham, Sabeel P Valappil
The purpose of this study was to determine whether or not the dual constant-depth film fermenter (dCDFF) is able to produce caries-like enamel lesions and to ascertain further information regarding the performance of this fully functional biological caries model. Conditions were defined by the continuation (CF) or cessation (FF) of a saliva-type growth medium supply during 50-mM sucrose exposures (8 times daily). Hydroxyapatite (n = 3) and bovine enamel (n = 3) substrata were included within each condition and samples extracted after 2, 4, 8, and 16 days...
March 1, 2017: Caries Research
https://www.readbyqxmd.com/read/28222429/effect-of-5-000-ppm-fluoride-dentifrice-or-1-100-ppm-fluoride-dentifrice-combined-with-acidulated-phosphate-fluoride-on-caries-lesion-inhibition-and-repair
#8
Constanza E Fernández, Livia Maria Andaló Tenuta, Altair Antoninha Del Bel Cury, Diego Figueiredo Nóbrega, Jaime Aparecido Cury
High fluoride dentifrice (FD; 5,000 ppm F) has been recommended to arrest root dentine lesions and to control enamel caries in high-risk patients. Also, standard FD (1,100 ppm F) in combination with professional fluoride application has been recommended to control dentine caries, but the effect of this combination on enamel has been considered modest. Considering the lack of evaluation comparing the use of 5,000 ppm FD (5,000-FD) versus acidulated phosphate fluoride (APF) application combined with 1,100 ppm FD (1,100-FD) on the inhibition and repair of caries lesions in both enamel and dentine, we conducted this in situ, double-blind, crossover study of 3 phases of 14 days...
February 22, 2017: Caries Research
https://www.readbyqxmd.com/read/28219064/editorial
#9
Vita Machiulskiene
No abstract text is available yet for this article.
2017: Caries Research
https://www.readbyqxmd.com/read/28219056/anticaries-potential-of-a-sodium-monofluorophosphate-dentifrice-containing-calcium-sodium-phosphosilicate-exploratory-in-situ-randomized-trial
#10
Charles R Parkinson, Muhammad Siddiqi, Stephen Mason, Frank Lippert, Anderson T Hara, Domenick T Zero
Calcium sodium phosphosilicate (CSPS) is a bioactive glass material that alleviates dentin hypersensitivity and is postulated to confer remineralization of caries lesions. This single-centre, randomized, single (investigator)-blind, placebo-controlled, crossover, in situ study explored whether the addition of 5% CSPS to a nonaqueous fluoride (F) such as sodium monofluorophosphate (SMFP)-containing dentifrice affects its cariostatic ability. Seventy-seven subjects wore 4 gauze-covered enamel specimens with preformed lesions (2 surface-softened and 2 subsurface) placed buccally on their mandibular bilateral dentures for up to 4 weeks...
2017: Caries Research
https://www.readbyqxmd.com/read/28178696/comment-on-the-paper-entitled-arginine-and-caries-prevention-a-systematic-review
#11
Roger Ellwood, William DeVizio
No abstract text is available yet for this article.
2017: Caries Research
https://www.readbyqxmd.com/read/28147347/ph-response-and-tooth-surface-solubility-at-the-tooth-bacteria-interface
#12
Gen Mayanagi, Koei Igarashi, Jumpei Washio, Nobuhiro Takahashi
Evaluating the physiochemical processes at the tooth surface/bacteria interface is important for elucidating the etiology of dental caries. This study aimed to compare the mineral solubility and protein degradation of coronal enamel (CE) and root dentin (RD), and investigate the involvement of dissolved components in bacteria-induced pH changes using a model of tooth/bacteria interface. An experimental apparatus forming a well was made of polymethyl methacrylate, and a bovine tooth (CE or RD) specimen was fixed at the bottom of the well...
2017: Caries Research
https://www.readbyqxmd.com/read/28132053/mechanisms-linking-interparental-aggression-to-child-dental-caries
#13
M F Lorber, D J N Maisson, A M S Slep, R E Heyman, M S Wolff
Research has garnered support for a systemic view of factors affecting child dental caries that accounts for the influence of social factors such as the family environment. Our previous work has demonstrated the association between mother-to-father emotional aggression and child caries. The present study builds on these results by evaluating pathways that might explain this relation. Families (n = 135) completed a multimethod assessment of mother-to-father emotional aggression, child caries, and several hypothesized mediators (i...
2017: Caries Research
https://www.readbyqxmd.com/read/28125809/frequency-of-application-of-amf-naf-sncl2-solution-and-its-potential-in-controlling-human-enamel-erosion-progression-an-in-situ-study
#14
C V da Silva, T M Ramos-Oliveira, T F Mantilla, P M de Freitas
Although several studies have demonstrated the efficacy of AmF/NaF/SnCl2 solution in inhibiting dental erosion progression, measures for further improvement in its effectiveness are paramount. Thus, this in situ study evaluated whether the protective effect promoted by the AmF/NaF/SnCl2 solution would be enhanced by increasing its frequency of use. The study was conducted with 12 volunteers, a 4-phase (5 days each) randomized, crossover model. Extraoral erosive challenges (0.5% citric acid, pH 2.6, 6 × 2 min/day) and rinsing protocol (1 or 2 × 2 min/day) were performed...
2017: Caries Research
https://www.readbyqxmd.com/read/28122369/the-effect-of-mucin-in-artificial-saliva-on-erosive-rehardening-and-demineralization
#15
Maisa C Jordão, Franciny Q Ionta, Bianca T P Bergantin, Gabriela C Oliveira, Marcelo J Moretto, Heitor M Honório, Thiago C Silva, Daniela Rios
The effect of mucin in artificial saliva on rehardening (RE-experiment) and inhibition (DE-experiment) of erosion was evaluated. The treatment groups were: artificial saliva with mucin, artificial saliva without mucin, human saliva, and water. For the RE-experiment, after immersion of enamel blocks in citric acid (4 min), hardness was measured and blocks were subjected to treatment for 2 h. For the DE-experiment, sound blocks were subjected to treatment for 2 h and immersed in citric acid (4 min). Percentages of hardness recovery (RE) and loss (DE) were analyzed (ANOVA/Tukey's test)...
2017: Caries Research
https://www.readbyqxmd.com/read/28122368/structural-analysis-of-enamel-in-teeth-from-head-and-neck-cancer-patients-who-underwent-radiotherapy
#16
Cristhian C Madrid, Mariana de Pauli Paglioni, Sergio R Line, Karina G Vasconcelos, Thaís Bianca Brandão, Marcio A Lopes, Alan Roger Santos-Silva, Mario Fernando De Goes
OBJECTIVE: To analyze macroscopic, microscopic, and ultrastructural aspects of enamel from head-and-neck cancer patients submitted to radiotherapy. MATERIALS AND METHODS: Twenty sound extracted permanent molars were used and divided into 2 groups. The experimental group consisted of 10 molars from head-and-neck cancer patients submitted to radiotherapy with total doses that ranged from 50 to 70 Gy. Ten molars from patients who did not receive radiotherapy were matched with experimental-group samples by anatomic tooth group and comprised the control group...
2017: Caries Research
https://www.readbyqxmd.com/read/28122367/enzymology-and-ultrastructure-of-the-in-situ-pellicle-in-caries-active-and-caries-inactive-patients
#17
Jasmin Kirsch, Christian Hannig, Sandra Pötschke, Sabine Basche, William H Bowen, Stefan Rupf, Simone Trautmann, Natalia Umanskaya, Matthias Hannig
AIM: The present study aimed to evaluate the impact of caries activity on the key enzymes and the ultrastructure of the in situ pellicle. METHODS: Pellicle formation was performed on bovine enamel slabs. Intraoral exposure (3, 30, and 120 min) was accomplished by 14 caries-active (DMFS: 22.7 ± 12.1) and 13 caries-inactive (DMFS: 1.5 ± 1.8) individuals. The enzyme activities (lysozyme, peroxidase, α-amylase, glycosyltransferase [GTF]) in the in situ pellicle and resting saliva of all participants were analyzed directly after oral exposure...
2017: Caries Research
https://www.readbyqxmd.com/read/28122365/protective-effect-of-phosphates-and-fluoride-on-the-dissolution-of-hydroxyapatite-and-their-interactions-with-saliva
#18
Michele M Manarelli, Juliano P Pessan, Alberto C B Delbem, Jackeline G Amaral, Mayra F Paiva, Michele E Barbour
This study aimed to investigate the effect of phosphates and fluoride, alone or in combination, and the influence of salivary pellicle on hydroxyapatite (HA) dissolution. The baseline dissolution rate of HA discs was measured using a pH-stat system (0.3% citric acid, pH 3.2). In the first series of experiments, HA discs (n = 8/group) were treated with: a placebo solution (PLA, deionised water); sodium trimetaphosphate (TMP), sodium tripolyphosphate (TRI) and sodium pyrophosphate (PYRO) at 1 or 8%; 500 ppm F; 1,100 ppm F; 1,100 ppm F/1% TMP; 1,100 ppm F/8% TMP; 1,100 ppm F/1% TRI; 1,100 ppm F/8% TRI...
2017: Caries Research
https://www.readbyqxmd.com/read/28122364/cariogenic-potential-of-sucrose-associated-with-maltodextrin-on-dental-enamel
#19
Gabriela Rezende, Rodrigo A Arthur, Debora Grando, Lina N Hashizume
Maltodextrin is a hydrolysate of cornstarch and has been widely used in the food industry associated with sucrose. The addition of starch can increase the cariogenic potential of sucrose; however, there are sparse data regarding the cariogenicity of sucrose associated with maltodextrin. Therefore, the aim of this study was to test in situ if maltodextrin could increase the cariogenic potential of sucrose. This was an in situ, randomized, crossover, split-mouth, and double-blind study. Volunteers wore palatal appliances containing bovine enamel blocks for 2 periods of 14 days...
2017: Caries Research
https://www.readbyqxmd.com/read/28118645/a-polymorphism-in-the-mtrr-gene-is-associated-with-early-childhood-caries-and-underweight
#20
Lívia Azeredo Alves Antunes, Claudio Manoel Cabral Machado, Ana Carolina Kuntz Couto, Ludiana Barbosa Lopes, Fernanda Cunha Sena, Fernanda Volpe Abreu, Renato Silva Fraga, Erika Calvano Küchler, Leonardo Santos Antunes
Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12. The present study aimed to evaluate the association of polymorphisms in genes MTR (rs1805087) and MTRR (rs1801394) with susceptibility of early childhood caries (ECC) and with body mass index alterations. A cross-sectional study was performed in 488 children aged from 2 to 6 years from 25 public day care centers in Rio de Janeiro, Brazil...
2017: Caries Research
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