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Caries Research

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https://www.readbyqxmd.com/read/28291962/matching-the-statistical-model-to-the-research-question-for-dental-caries-indices-with-many-zero-counts
#1
John S Preisser, D Leann Long, John W Stamm
Marginalized zero-inflated count regression models have recently been introduced for the statistical analysis of dental caries indices and other zero-inflated count data as alternatives to traditional zero-inflated and hurdle models. Unlike the standard approaches, the marginalized models directly estimate overall exposure or treatment effects by relating covariates to the marginal mean count. This article discusses model interpretation and model class choice according to the research question being addressed in caries research...
March 15, 2017: Caries Research
https://www.readbyqxmd.com/read/28245470/evidence-of-an-in-vitro-coupled-diffusion-mechanism-of-lesion-formation-within-microcosm-dental-plaque
#2
Gareth J Owens, Richard J M Lynch, Christopher K Hope, Lee Cooper, Susan M Higham, Sabeel P Valappil
The purpose of this study was to determine whether or not the dual constant-depth film fermenter (dCDFF) is able to produce caries-like enamel lesions and to ascertain further information regarding the performance of this fully functional biological caries model. Conditions were defined by the continuation (CF) or cessation (FF) of a saliva-type growth medium supply during 50-mM sucrose exposures (8 times daily). Hydroxyapatite (n = 3) and bovine enamel (n = 3) substrata were included within each condition and samples extracted after 2, 4, 8, and 16 days...
March 1, 2017: Caries Research
https://www.readbyqxmd.com/read/28222429/effect-of-5-000-ppm-fluoride-dentifrice-or-1-100-ppm-fluoride-dentifrice-combined-with-acidulated-phosphate-fluoride-on-caries-lesion-inhibition-and-repair
#3
Constanza E Fernández, Livia Maria Andaló Tenuta, Altair Antoninha Del Bel Cury, Diego Figueiredo Nóbrega, Jaime Aparecido Cury
High fluoride dentifrice (FD; 5,000 ppm F) has been recommended to arrest root dentine lesions and to control enamel caries in high-risk patients. Also, standard FD (1,100 ppm F) in combination with professional fluoride application has been recommended to control dentine caries, but the effect of this combination on enamel has been considered modest. Considering the lack of evaluation comparing the use of 5,000 ppm FD (5,000-FD) versus acidulated phosphate fluoride (APF) application combined with 1,100 ppm FD (1,100-FD) on the inhibition and repair of caries lesions in both enamel and dentine, we conducted this in situ, double-blind, crossover study of 3 phases of 14 days...
February 22, 2017: Caries Research
https://www.readbyqxmd.com/read/28219064/editorial
#4
Vita Machiulskiene
No abstract text is available yet for this article.
2017: Caries Research
https://www.readbyqxmd.com/read/28219056/anticaries-potential-of-a-sodium-monofluorophosphate-dentifrice-containing-calcium-sodium-phosphosilicate-exploratory-in-situ-randomized-trial
#5
Charles R Parkinson, Muhammad Siddiqi, Stephen Mason, Frank Lippert, Anderson T Hara, Domenick T Zero
Calcium sodium phosphosilicate (CSPS) is a bioactive glass material that alleviates dentin hypersensitivity and is postulated to confer remineralization of caries lesions. This single-centre, randomized, single (investigator)-blind, placebo-controlled, crossover, in situ study explored whether the addition of 5% CSPS to a nonaqueous fluoride (F) such as sodium monofluorophosphate (SMFP)-containing dentifrice affects its cariostatic ability. Seventy-seven subjects wore 4 gauze-covered enamel specimens with preformed lesions (2 surface-softened and 2 subsurface) placed buccally on their mandibular bilateral dentures for up to 4 weeks...
2017: Caries Research
https://www.readbyqxmd.com/read/28178696/comment-on-the-paper-entitled-arginine-and-caries-prevention-a-systematic-review
#6
Roger Ellwood, William DeVizio
No abstract text is available yet for this article.
2017: Caries Research
https://www.readbyqxmd.com/read/28147347/ph-response-and-tooth-surface-solubility-at-the-tooth-bacteria-interface
#7
Gen Mayanagi, Koei Igarashi, Jumpei Washio, Nobuhiro Takahashi
Evaluating the physiochemical processes at the tooth surface/bacteria interface is important for elucidating the etiology of dental caries. This study aimed to compare the mineral solubility and protein degradation of coronal enamel (CE) and root dentin (RD), and investigate the involvement of dissolved components in bacteria-induced pH changes using a model of tooth/bacteria interface. An experimental apparatus forming a well was made of polymethyl methacrylate, and a bovine tooth (CE or RD) specimen was fixed at the bottom of the well...
2017: Caries Research
https://www.readbyqxmd.com/read/28132053/mechanisms-linking-interparental-aggression-to-child-dental-caries
#8
M F Lorber, D J N Maisson, A M S Slep, R E Heyman, M S Wolff
Research has garnered support for a systemic view of factors affecting child dental caries that accounts for the influence of social factors such as the family environment. Our previous work has demonstrated the association between mother-to-father emotional aggression and child caries. The present study builds on these results by evaluating pathways that might explain this relation. Families (n = 135) completed a multimethod assessment of mother-to-father emotional aggression, child caries, and several hypothesized mediators (i...
2017: Caries Research
https://www.readbyqxmd.com/read/28125809/frequency-of-application-of-amf-naf-sncl2-solution-and-its-potential-in-controlling-human-enamel-erosion-progression-an-in-situ-study
#9
C V da Silva, T M Ramos-Oliveira, T F Mantilla, P M de Freitas
Although several studies have demonstrated the efficacy of AmF/NaF/SnCl2 solution in inhibiting dental erosion progression, measures for further improvement in its effectiveness are paramount. Thus, this in situ study evaluated whether the protective effect promoted by the AmF/NaF/SnCl2 solution would be enhanced by increasing its frequency of use. The study was conducted with 12 volunteers, a 4-phase (5 days each) randomized, crossover model. Extraoral erosive challenges (0.5% citric acid, pH 2.6, 6 × 2 min/day) and rinsing protocol (1 or 2 × 2 min/day) were performed...
2017: Caries Research
https://www.readbyqxmd.com/read/28122369/the-effect-of-mucin-in-artificial-saliva-on-erosive-rehardening-and-demineralization
#10
Maisa C Jordão, Franciny Q Ionta, Bianca T P Bergantin, Gabriela C Oliveira, Marcelo J Moretto, Heitor M Honório, Thiago C Silva, Daniela Rios
The effect of mucin in artificial saliva on rehardening (RE-experiment) and inhibition (DE-experiment) of erosion was evaluated. The treatment groups were: artificial saliva with mucin, artificial saliva without mucin, human saliva, and water. For the RE-experiment, after immersion of enamel blocks in citric acid (4 min), hardness was measured and blocks were subjected to treatment for 2 h. For the DE-experiment, sound blocks were subjected to treatment for 2 h and immersed in citric acid (4 min). Percentages of hardness recovery (RE) and loss (DE) were analyzed (ANOVA/Tukey's test)...
2017: Caries Research
https://www.readbyqxmd.com/read/28122368/structural-analysis-of-enamel-in-teeth-from-head-and-neck-cancer-patients-who-underwent-radiotherapy
#11
Cristhian C Madrid, Mariana de Pauli Paglioni, Sergio R Line, Karina G Vasconcelos, Thaís Bianca Brandão, Marcio A Lopes, Alan Roger Santos-Silva, Mario Fernando De Goes
OBJECTIVE: To analyze macroscopic, microscopic, and ultrastructural aspects of enamel from head-and-neck cancer patients submitted to radiotherapy. MATERIALS AND METHODS: Twenty sound extracted permanent molars were used and divided into 2 groups. The experimental group consisted of 10 molars from head-and-neck cancer patients submitted to radiotherapy with total doses that ranged from 50 to 70 Gy. Ten molars from patients who did not receive radiotherapy were matched with experimental-group samples by anatomic tooth group and comprised the control group...
2017: Caries Research
https://www.readbyqxmd.com/read/28122367/enzymology-and-ultrastructure-of-the-in-situ-pellicle-in-caries-active-and-caries-inactive-patients
#12
Jasmin Kirsch, Christian Hannig, Sandra Pötschke, Sabine Basche, William H Bowen, Stefan Rupf, Simone Trautmann, Natalia Umanskaya, Matthias Hannig
AIM: The present study aimed to evaluate the impact of caries activity on the key enzymes and the ultrastructure of the in situ pellicle. METHODS: Pellicle formation was performed on bovine enamel slabs. Intraoral exposure (3, 30, and 120 min) was accomplished by 14 caries-active (DMFS: 22.7 ± 12.1) and 13 caries-inactive (DMFS: 1.5 ± 1.8) individuals. The enzyme activities (lysozyme, peroxidase, α-amylase, glycosyltransferase [GTF]) in the in situ pellicle and resting saliva of all participants were analyzed directly after oral exposure...
2017: Caries Research
https://www.readbyqxmd.com/read/28122365/protective-effect-of-phosphates-and-fluoride-on-the-dissolution-of-hydroxyapatite-and-their-interactions-with-saliva
#13
Michele M Manarelli, Juliano P Pessan, Alberto C B Delbem, Jackeline G Amaral, Mayra F Paiva, Michele E Barbour
This study aimed to investigate the effect of phosphates and fluoride, alone or in combination, and the influence of salivary pellicle on hydroxyapatite (HA) dissolution. The baseline dissolution rate of HA discs was measured using a pH-stat system (0.3% citric acid, pH 3.2). In the first series of experiments, HA discs (n = 8/group) were treated with: a placebo solution (PLA, deionised water); sodium trimetaphosphate (TMP), sodium tripolyphosphate (TRI) and sodium pyrophosphate (PYRO) at 1 or 8%; 500 ppm F; 1,100 ppm F; 1,100 ppm F/1% TMP; 1,100 ppm F/8% TMP; 1,100 ppm F/1% TRI; 1,100 ppm F/8% TRI...
2017: Caries Research
https://www.readbyqxmd.com/read/28122364/cariogenic-potential-of-sucrose-associated-with-maltodextrin-on-dental-enamel
#14
Gabriela Rezende, Rodrigo A Arthur, Debora Grando, Lina N Hashizume
Maltodextrin is a hydrolysate of cornstarch and has been widely used in the food industry associated with sucrose. The addition of starch can increase the cariogenic potential of sucrose; however, there are sparse data regarding the cariogenicity of sucrose associated with maltodextrin. Therefore, the aim of this study was to test in situ if maltodextrin could increase the cariogenic potential of sucrose. This was an in situ, randomized, crossover, split-mouth, and double-blind study. Volunteers wore palatal appliances containing bovine enamel blocks for 2 periods of 14 days...
2017: Caries Research
https://www.readbyqxmd.com/read/28118645/a-polymorphism-in-the-mtrr-gene-is-associated-with-early-childhood-caries-and-underweight
#15
Lívia Azeredo Alves Antunes, Claudio Manoel Cabral Machado, Ana Carolina Kuntz Couto, Ludiana Barbosa Lopes, Fernanda Cunha Sena, Fernanda Volpe Abreu, Renato Silva Fraga, Erika Calvano Küchler, Leonardo Santos Antunes
Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12. The present study aimed to evaluate the association of polymorphisms in genes MTR (rs1805087) and MTRR (rs1801394) with susceptibility of early childhood caries (ECC) and with body mass index alterations. A cross-sectional study was performed in 488 children aged from 2 to 6 years from 25 public day care centers in Rio de Janeiro, Brazil...
2017: Caries Research
https://www.readbyqxmd.com/read/28118640/inhibition-of-streptococcus-mutans-growth-and-biofilm-formation-by-probiotics-in-vitro
#16
Falk Schwendicke, Franziska Korte, Christof E Dörfer, Susanne Kneist, Karim Fawzy El-Sayed, Sebastian Paris
To exert anticaries effects, probiotics are described to inhibit growth and biofilm formation of cariogenic bacteria such as Streptococcus mutans (SM). We screened 8 probiotics and assessed how SM growth or biofilm formation inhibition affects cariogenicity of probiotic-SM mixed-species biofilms in vitro. Growth inhibition was assessed by cocultivating probiotics and 2 SM strains (ATCC 20532/25175) on agar. Probiotics were either precultured before SM cultivation (exclusion), or SM precultured prior to probiotic cultivation (displacement)...
2017: Caries Research
https://www.readbyqxmd.com/read/28110341/farewell-to-professor-dr-jol%C3%A3-n-b%C3%A3-n%C3%A3-czy
#17
Zsuzsanna Tóth
No abstract text is available yet for this article.
2017: Caries Research
https://www.readbyqxmd.com/read/28088794/the-lack-of-association-between-fcn2-gene-promoter-region-polymorphisms-and-dental-caries-in-polish-children
#18
T Olszowski, M Milona, J Janiszewska-Olszowska, K Safranow, K Skonieczna-Żydecka, A Walczak, M Sikora, D Chlubek, A Madlani, G Adler
The aim of this study was to examine the association of single-nucleotide polymorphisms (SNPs) in the gene encoding ficolin-2 protein (FCN2 gene) at positions -986 (rs17514136), -602 (rs3124953), and -4 (rs3124952) with dental caries in Polish children. Two hundred and sixty Polish Caucasian children aged 15 years were enrolled in this study: 82 with "higher" caries experience (DMFT >5) and 178 with "lower" caries experience (DMFT ≤5). In addition, subjects with caries experience (DMFT ≥1) and caries-free subjects (DMFT = 0) were compared...
2017: Caries Research
https://www.readbyqxmd.com/read/28006773/discrete-distribution-based-on-compound-sum-to-model-dental-caries-count-data
#19
Jean-Noel Vergnes, Jean-Philippe Boucher, Nathalie Lelong, Michel Sixou, Cathy Nabet
Methods for analysing dental caries and associated risk indicators have evolved considerably in recent decades. The use of zero-inflated or hurdle models is increasing so as to take account of the decayed, missing, and filled teeth (DMFT) distribution, which is positively skewed and has a high proportion of zero scores. However, there is a need to develop new statistical models that involve pragmatic biological considerations on dental caries in epidemiological surveys. In this paper, we show that the zero-inflated and the hurdle models can both be expressed as a compound sum...
2017: Caries Research
https://www.readbyqxmd.com/read/28002827/the-in-vivo-inhibition-of-oral-biofilm-accumulation-and-streptococcus-mutans-by-ceramic-water
#20
Ryota Nomura, Risa Yoneyama, Shuhei Naka, Masatoshi Otsugu, Yuko Ogaya, Rina Hatakeyama, Yumiko Morita, Jumpei Maruo, Michiyo Matsumoto-Nakano, Osamu Yamada, Kazuhiko Nakano
Combustion-synthesized titanium carbide ceramics uniformly disperse silver, producing silver ions and hydroxyl radicals in water. This generates antimicrobial activity against various bacteria. One such bacterium is Streptococcus mutans, a gram-positive anaerobic bacterium known as a major pathogen of dental caries. In this study, we analyzed the inhibition of oral biofilms and S. mutans by ceramic water in in vitro and human studies. S. mutans strains showed significantly lower antimicrobial and sucrose-dependent adhesion activity in the presence of ceramic powder compared with untreated culture medium...
2017: Caries Research
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