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Caries Research

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https://www.readbyqxmd.com/read/28088794/the-lack-of-association-between-fcn2-gene-promoter-region-polymorphisms-and-dental-caries-in-polish-children
#1
T Olszowski, M Milona, J Janiszewska-Olszowska, K Safranow, K Skonieczna-Żydecka, A Walczak, M Sikora, D Chlubek, A Madlani, G Adler
The aim of this study was to examine the association of single-nucleotide polymorphisms (SNPs) in the gene encoding ficolin-2 protein (FCN2 gene) at positions -986 (rs17514136), -602 (rs3124953), and -4 (rs3124952) with dental caries in Polish children. Two hundred and sixty Polish Caucasian children aged 15 years were enrolled in this study: 82 with "higher" caries experience (DMFT >5) and 178 with "lower" caries experience (DMFT ≤5). In addition, subjects with caries experience (DMFT ≥1) and caries-free subjects (DMFT = 0) were compared...
January 14, 2017: Caries Research
https://www.readbyqxmd.com/read/28006773/discrete-distribution-based-on-compound-sum-to-model-dental-caries-count-data
#2
Jean-Noel Vergnes, Jean-Philippe Boucher, Nathalie Lelong, Michel Sixou, Cathy Nabet
Methods for analysing dental caries and associated risk indicators have evolved considerably in recent decades. The use of zero-inflated or hurdle models is increasing so as to take account of the decayed, missing, and filled teeth (DMFT) distribution, which is positively skewed and has a high proportion of zero scores. However, there is a need to develop new statistical models that involve pragmatic biological considerations on dental caries in epidemiological surveys. In this paper, we show that the zero-inflated and the hurdle models can both be expressed as a compound sum...
December 23, 2016: Caries Research
https://www.readbyqxmd.com/read/28002827/the-in-vivo-inhibition-of-oral-biofilm-accumulation-and-streptococcus-mutans-by-ceramic-water
#3
Ryota Nomura, Risa Yoneyama, Shuhei Naka, Masatoshi Otsugu, Yuko Ogaya, Rina Hatakeyama, Yumiko Morita, Jumpei Maruo, Michiyo Matsumoto-Nakano, Osamu Yamada, Kazuhiko Nakano
Combustion-synthesized titanium carbide ceramics uniformly disperse silver, producing silver ions and hydroxyl radicals in water. This generates antimicrobial activity against various bacteria. One such bacterium is Streptococcus mutans, a gram-positive anaerobic bacterium known as a major pathogen of dental caries. In this study, we analyzed the inhibition of oral biofilms and S. mutans by ceramic water in in vitro and human studies. S. mutans strains showed significantly lower antimicrobial and sucrose-dependent adhesion activity in the presence of ceramic powder compared with untreated culture medium...
December 22, 2016: Caries Research
https://www.readbyqxmd.com/read/27992873/mmp20-rs1784418-protects-certain-populations-against-caries
#4
Arnôldo V A Filho, Merilene S Calixto, Kathleen Deeley, Neide Santos, Aronita Rosenblatt, Alexandre R Vieira
This work aimed to further evaluate the association of MMP20 rs1784418 C>T and dental caries experience with the hypothesis that MMP20 rs1784418 C>T is a risk factor for dental caries. 184 children 4-7 years of age had their caries experience determined and buccal cheek swabs collected for DNA extraction to test for association with the MMP20 rs1784418 C>T using standard statistical approaches. A meta-analytic approach was also implemented to compile previous discrepant reports of the same association...
December 20, 2016: Caries Research
https://www.readbyqxmd.com/read/27992868/do-abrasives-play-a-role-in-toothpaste-efficacy-against-erosion-abrasion
#5
Carolina Ganss, Maike Möllers, Nadine Schlueter
Abrasives may counteract the efficacy of anti-erosion toothpastes either due to physical effects or due to interaction with active agents. This study aimed to investigate whether the amount of abrasives is a determinant for the efficacy of Sn2+-containing toothpastes with or without chitosan additive. Enamel samples were eroded (0.50 wt% citric acid, pH 2.5; 6 × 2 min/day) on a shaking desk - 30/min in experiment 1 (E1) and 35/min in experiments 2 (E2) and 3 (E3) - and immersed in toothpaste slurries (2 × 2 min)...
December 20, 2016: Caries Research
https://www.readbyqxmd.com/read/27960182/calcium-phosphate-osteopontin-particles-reduce-biofilm-formation-and-ph-drops-in-in-situ-grown-dental-biofilms
#6
Sebastian Schlafer, Casper J S Ibsen, Henrik Birkedal, Bente Nyvad
This 2-period crossover study investigated the effect of calcium-phosphate-osteopontin particles on biofilm formation and pH in 48-h biofilms grown in situ. Bovine milk osteopontin is a highly phosphorylated glycoprotein that has been shown to interfere with bacterial adhesion to salivary-coated surfaces. Calcium-phosphate-osteopontin particles have been shown to reduce biofilm formation and pH drops in a 5-species laboratory model of dental biofilm without affecting bacterial viability. Here, smooth surface biofilms from 10 individuals were treated ex vivo 6 times/day for 30 min with either calcium-phosphate-osteopontin particles or sterile saline...
December 14, 2016: Caries Research
https://www.readbyqxmd.com/read/27960156/effect-of-tannic-acid-on-the-protective-properties-of-the-in-situ-formed-pellicle
#7
Susann Hertel, Sandra Pötschke, Sabine Basche, Judith Delius, Wiebke Hoth-Hannig, Matthias Hannig, Christian Hannig
OBJECTIVES: In the present in situ/ex vivo study the impact of tannic acid on the erosion-protective properties of the enamel pellicle was tested. Additionally, the antiadherent and antibacterial effects of tannic acid were evaluated. METHODS: The pellicle was formed in situ on bovine enamel samples fixed on individual splints worn by 6 subjects. Following 1 min of pellicle formation the volunteers rinsed for 10 min with tannic acid. After further oral exposure for 19 min, 109 min, and 8 h overnight, respectively, slabs were incubated in HCl ex vivo (pH 2...
December 14, 2016: Caries Research
https://www.readbyqxmd.com/read/27898426/maternal-depression-increases-childhood-dental-caries-a-cohort-study-in-brazil
#8
Gabriela Dos Santos Pinto, Luciana de Ávila Quevedo, Marcos Britto Correa, Marina Sousa Azevedo, Marília Leão Goettems, Ricardo Tavares Pinheiro, Flávio Fernando Demarco
AIM: To investigate the relationship between maternal depression and childhood caries in a cohort of adolescent mothers. METHODS: This cross-sectional study nested in a cohort evaluated a sample of 538 mother/child dyads. When the children were 24-36 months of age, data regarding oral health from children and mothers were collected by clinical dental examination. A mother's major depressive disorder was assessed by using the Mini International Neuropsychiatric Interview (MINI [Plus]), at the current moment...
November 30, 2016: Caries Research
https://www.readbyqxmd.com/read/27894112/association-of-mbl2-gene-polymorphism-with-dental-caries-in-saudi-children
#9
Yousef M Alyousef, J Francis Borgio, Sayed AbdulAzeez, Naif Al-Masoud, Ali A Al-Ali, Emad Al-Shwaimi, Amein K Al-Ali
The high prevalence of dental caries in children worldwide is a major oral health problem which requires early intervention. Dental caries is mainly caused by the action of acids produced by bacteria in addition to many other factors. Recent genetic studies have reported that a number of genes are associated with the susceptibility to dental caries. The majority of these genes are associated with inflammation, increased susceptibility to infection, and dentine matrix formation. Using the TaqMan assay and direct DNA sequencing, the prevalence of 6 single-nucleotide polymorphisms (SNPs) in MMP9, MBL2, MMP2, and TIMP2 genes was determined in 102 children with caries and in 100 age-matched caries-free controls...
November 29, 2016: Caries Research
https://www.readbyqxmd.com/read/27889775/vitamin-d-receptor-taqi-gene-polymorphism-and-dental-caries-in-czech-children
#10
Lydie Izakovicova Holla, Petra Borilova Linhartova, Jakub Kastovsky, Michaela Bartosova, Kristina Musilova, Lubomir Kukla, Martina Kukletova
AIM: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. METHODS: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method. RESULTS: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0...
November 26, 2016: Caries Research
https://www.readbyqxmd.com/read/27846621/unstimulated-saliva-related-caries-risk-factors-in-individuals-with-cystic-fibrosis-a-cross-sectional-analysis-of-unstimulated-salivary-flow-ph-and-buffering-capacity
#11
Alaa A Alkhateeb, Lloyd A Mancl, Richard B Presland, Marilynn L Rothen, Donald L Chi
Salivary flow rate, pH, and buffering capacity are associated with dental caries, but studies from the cystic fibrosis (CF) literature are inconclusive regarding these salivary factors and caries. The aim of this study was to evaluate these factors and their associations with dental caries in individuals with CF. Unstimulated whole saliva was collected from individuals aged 6-20 years at Seattle Children's Hospital CF Clinic, USA (n = 83). Salivary flow rate was measured in milliliters per minute. Salivary pH was assessed using a laboratory pH meter...
November 16, 2016: Caries Research
https://www.readbyqxmd.com/read/27907916/orca-announcements
#12
Zsuzsanna Tóth
No abstract text is available yet for this article.
2016: Caries Research
https://www.readbyqxmd.com/read/27846636/caries-and-innate-immunity-defb1-gene-polymorphisms-and-caries-susceptibility-in-genetic-isolates-from-north-eastern-italy
#13
Chiara O Navarra, Antonietta Robino, Nicola Pirastu, Lorenzo Bevilacqua, Paolo Gasparini, Roberto Di Lenarda, Sergio Crovella
BACKGROUND: The DEFB1 gene, encoding for the constitutively expressed human β-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis. METHODS: We analysed 5 DEFB1 polymorphisms, namely 3 functional single-nucleotide polymorphisms (SNPs) at the 5'-untranslated region (UTR), -52G>A (rs1799946), -44C>G (rs1800972), and -20G>A (rs11362), 2 SNPs at the 3'-UTR, c*5G>A (rs1047031) and c*87A>G (rs1800971) SNP located in potential miRNA binding sites, looking for possible correlations with the risk to develop caries in 654 adult subjects from isolated populations of north-eastern Italy...
2016: Caries Research
https://www.readbyqxmd.com/read/27811470/remineralizing-potential-of-a-low-fluoride-toothpaste-with-sodium-trimetaphosphate-an-in-situ-study
#14
Eliana M Takeshita, Marcelle Danelon, Luciene P Castro, Robson F Cunha, Alberto C B Delbem
OBJECTIVE: To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ. DESIGN: Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment groups, according to the toothpastes used: without F or TMP (placebo); 500 ppm F; 500 ppm F plus 1% TMP; and 1,100 ppm F. The study design was blinded and crossover and performed in 4 phases of 3 days each...
2016: Caries Research
https://www.readbyqxmd.com/read/27806364/long-term-effect-of-erythritol-on-dental-caries-development-during-childhood-a-posttreatment-survival-analysis
#15
Gwen Falony, Sisko Honkala, Riina Runnel, Jana Olak, Rita Nõmmela, Silvia Russak, Mare Saag, Pirkko-Liisa Mäkinen, Kauko Mäkinen, Tero Vahlberg, Eino Honkala
OBJECTIVE: To assess the effect of daily consumption of erythritol, xylitol, and sorbitol candies on caries development in mixed dentition during a 3-year intervention and 3 years after the intervention. METHODS: 485 Estonian first- and second-grade primary school children participated. Children were randomly allocated to an erythritol, xylitol, or sorbitol (control) group. Polyol-containing candies were administered on school days with a daily polyol consumption of 3 × 2...
2016: Caries Research
https://www.readbyqxmd.com/read/27788518/association-between-type-amount-and-pattern-of-carbohydrate-consumption-with-dental-caries-in-12-year-olds-in-puerto-rico
#16
Cristina Palacios, Sona Rivas-Tumanyan, Evangelia Morou-Bermúdez, Alina M Colon, Roxana Y Torres, Augusto R Elías-Boneta
OBJECTIVE: To identify the types, food sources, and pattern of carbohydrates that significantly contribute to dental caries in Puerto Rican children. METHODS: As part of an island-wide cross-sectional oral health study in 1,587 twelve-year-olds, diet intake was assessed in a representative subset (n = 801) with a 24-hour dietary recall. Carbohydrate intake was quantified using a computer-based diet analysis program. Caries was assessed using the National Institute of Dental and Craniofacial Research diagnostic criteria...
2016: Caries Research
https://www.readbyqxmd.com/read/27705968/social-factors-associated-with-the-decline-in-caries-in-brazilian-children-between-1996-and-2010
#17
Angelo Giuseppe Roncalli, Aubrey Sheiham, Georgios Tsakos, Georgia Costa de Araújo-Souza, Richard G Watt
Dental caries levels have declined in children since the 1970s in many countries. Most of the postulated main reasons for the decline are speculative and have not been rigorously evaluated. The objective of this study was to assess the relationship between some social factors and the decline in dental caries in Brazilian 12-year-old children from 1996 to 2010. Secondary analysis of national data was performed in 27 Brazilian state capitals. A panel data regression model with fixed effects and multiple linear regression were used to verify the relationship between the explanatory and the dependent variables and also the time-trend effect...
2016: Caries Research
https://www.readbyqxmd.com/read/27694757/the-prevalence-of-tooth-wear-in-the-dutch-adult-population
#18
Peter Wetselaar, Jan H Vermaire, Corine M Visscher, Frank Lobbezoo, Annemarie A Schuller
This study aimed to assess the prevalence of tooth wear in different age groups of the Dutch adult population and to determine this tooth wear distribution by gender, socioeconomic class, and type of teeth. Results were compared with the outcomes of a previous study in a comparable population. As part of a comprehensive investigation of the oral health of the general Dutch adult population in 2013, tooth wear was assessed among 1,125 subjects in the city of 's-Hertogenbosch. The data collected were subjected to stratified analysis by 5 age groups (25-34, 35-44, 45-54, 55-64, and 65-74 years), gender, socioeconomic class, and type of teeth...
2016: Caries Research
https://www.readbyqxmd.com/read/27658123/occlusal-caries-biological-approach-for-its-diagnosis-and-management
#19
Joana Christina Carvalho, Irene Dige, Vita Machiulskiene, Vibeke Qvist, Azam Bakhshandeh, Clarissa Fatturi-Parolo, Marisa Maltz
The management of occlusal caries still remains a major challenge for researchers as well as for general practitioners. The present paper reviews and discusses the most up-to-date knowledge and evidence of the biological principles guiding diagnosis, risk assessment, and management of the caries process on occlusal surfaces. In addition, it considers the whole spectrum of the caries process on occlusal surfaces, ranging from the molecular ecology of occlusal biofilms to the management of deep occlusal caries lesions...
2016: Caries Research
https://www.readbyqxmd.com/read/27639918/modeling-caries-experience-advantages-of-the-use-of-the-hurdle-model
#20
Hedwig Hofstetter, Elise Dusseldorp, Achim Zeileis, Annemarie A Schuller
In dental epidemiology, the decayed (D), missing (M), and filled (F) teeth or surfaces index (DFM index) is a frequently used measure. The DMF index is characterized by a strongly positive skewed distribution with a large stack of zero counts for those individuals without caries experience. Therefore, standard generalized linear models often lead to a poor fit. The hurdle regression model is a highly suitable class to model a DMF index, but its use is subordinated. We aim to overcome the gap between the suitability of the hurdle model to fit DMF indices and the frequency of its use in caries research...
2016: Caries Research
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