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Journal of Comparative Pathology

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https://www.readbyqxmd.com/read/27923479/immune-cell-infiltration-in-feline-meningioma
#1
R McBride, E A Sloma, H N Erb, A D Miller
Meningioma is the most common primary brain tumour in the cat. Although most of these tumours are considered to be benign based on histological characteristics, little is known regarding microenvironmental changes associated with the tumour. The characterization of the immune-cell infiltrate in human and canine meningiomas has been described; however, there are no data regarding the cat equivalent. Seventeen formalin-fixed, paraffin wax-embedded samples of feline meningioma were evaluated by light microscopy and immunohistochemistry (IHC) for expression of CD3, Pax5, Iba-1, HLA-DR, MAC387, CD163 and Ki67...
December 3, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27908555/dental-pathology-of-the-hoary-marmot-marmota-caligata-groundhog-marmota-monax-and-alaska-marmot-marmota-broweri
#2
J N Winer, B Arzi, D M Leale, P H Kass, F J M Verstraete
Museum specimens (maxillae and mandibles) of the three marmot species occurring in Alaska (Marmota caligata [n = 108 specimens], Marmota monax [n = 30] and Marmota broweri [n = 24]) were examined macroscopically according to predefined criteria. There were 71 specimens (43.8%) from female animals, 69 (42.6%) from male animals and 22 (13.6%) from animals of unknown sex. The ages of animals ranged from neonatal to adult, with 121 young adults (74.4%) and 41 adults (25.3%) included, and 168 excluded from study due to neonatal/juvenile age or incompleteness of specimens (missing part of the dentition)...
November 28, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27899174/concurrent-gliosarcoma-and-choroid-plexus-carcinoma-in-a-cow
#3
A Ortloff, J Neumann, O Illanes
Brain tumours in cattle are uncommon and the spontaneous development of primary brain tumours of different histological types is rare in both man and animals. In man, multiple concurrent primary tumours of different types are occasionally described. We report the rare simultaneous occurrence of two different primary brain tumours, gliosarcoma and choroid plexus carcinoma, diagnosed by microscopical and immunofluorescence evaluation in an 8-year-old cow with a 2-month history of neurological disease. Gliosarcoma is a rare variant of glioblastoma multiforme, characterized by the presence of malignant glial cells and mesenchymal tissue...
November 26, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27894597/unexpected-cardiac-death-during-anaesthesia-of-a-young-rabbit-associated-with-fibro-fatty-replacement-of-the-right-ventricular-myocardium
#4
M Romanucci, S V P Defourny, M Massimini, V Valerii, A Arbuatti, V Giordano, L Bongiovanni, C Perrone, L Della Salda
A 6-month-old female pet rabbit was presented for routine ovariectomy. The pre-anaesthetic evaluation was unremarkable and no anaesthetic complications occurred during the procedure. However, at the end of the surgery, the rabbit suddenly showed acute bradycardia and cardiac death. Necropsy examination revealed marked dilation of the right ventricle, associated with diffuse thinning of the right ventricular free wall. Gross and histopathological findings were suggestive of a congenital dilated cardiomyopathy characterized by fibro-fatty replacement of the right ventricular myocardium...
November 25, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27890406/cutaneous-histiocytic-sarcoma-with-regional-lymph-node-metastasis-in-a-netherland-dwarf-rabbit-oryctolagus-cuniculus
#5
M R Karim, T Izawa, M Pervin, H Sasai, M Kuwamura, J Yamate
A 10-year-old male Netherland dwarf rabbit (Oryctolagus cuniculus) was presented with a red nodular mass (1 cm in diameter) with ulceration and hair loss in the skin of the left upper lip. Cytological examination revealed atypical round cells. The mass was excised surgically. Histologically, the mass was composed of large round to polyhedral neoplastic cells with marked cytological atypia. The neoplastic cells were often binucleated or multinucleated. Immunohistochemically, the neoplastic cells were intensely positive for Iba1 and vimentin, but fewer neoplastic cells expressed E-cadherin...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27890405/platelets-inhibit-migration-of-canine-osteosarcoma-cells
#6
S C Bulla, P R Badial, R C Silva, K Lunsford, C Bulla
The interaction between platelets and tumour cells is important for tumour growth and metastasis. Thrombocytopenia or antiplatelet treatment negatively impact on cancer metastasis, demonstrating potentially important roles for platelets in tumour progression. To our knowledge, there is no information regarding the role of platelets in cancer progression in dogs. This study was designed to test whether canine platelets affected the migratory behaviour of three canine osteosarcoma cell lines and to give insights of molecular mechanisms...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27890404/incomplete-urethral-duplication-associated-with-a-dermoid-cyst-in-a-dog-with-urinary-obstruction
#7
F Thierry, S Drew, J Del-Pozo, N Fernandez-Salesa, S Woods, G Stanzani, T Liuti
A 20-month-old male miniature dachshund was evaluated for a 10-week history of intermittent stranguria, pollakiuria, haematuria and obstructive urolithiasis. Retrograde urethrocystography revealed a subcutaneous saccular structure in the perineal area connected to the intrapelvic urethra associated with urolithiasis. After excision of the perineal saccular structure, microscopical examination confirmed the presence of transitional epithelium lining the diverticulum, with isolated submucosal smooth muscle bundles...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27889201/expression-of-fibroblast-activating-protein-and-correlation-with-histological-grade-mitotic-index-and-ki67-expression-in-canine-mast-cell-tumours
#8
A Giuliano, R Dos Santos Horta, F Costantino-Casas, T Hoather, J Dobson
Fibroblast activating protein (FAP) is a membrane serine protease expressed by activated fibroblasts, particularly tumour associated fibroblasts (TAFs). FAP expression has not been reported in canine mast cell tumours (MCTs). The objective of this study was to evaluate the expression of FAP in TAFs and its correlation with histological grade, mitotic index and Ki67 expression in canine MCTs. FAP expression was evaluated by immunohistochemistry (IHC) in 30 canine MCTs. Twenty-eight (90%) of the MCTs expressed FAP in the stroma, 16 cases showed low to intermediate FAP score and 14 cases had a high FAP score...
November 24, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27865423/embryonal-rhabdomyosarcoma-of-the-oesophagus-in-a-young-dog
#9
N Devriendt, L Van Brantegem, A Willems, E Raes, H de Rooster
A 15-month-old great Dane dog, showing clinical signs related to hypertrophic osteopathy, was diagnosed radiographically with a mass in the region of the thoracic oesophagus. Exploratory thoracotomy revealed an extensive, highly vascularized and locally invasive oesophageal mass and the presence of nodules in adjacent lung lobes. The dog was humanely destroyed intra-operatively. Histological examination revealed that the mass was an embryonal rhabdomyosarcoma. This is the first report of rhabdomyosarcoma of the oesophagus of a dog...
November 16, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27863700/the-journal-of-comparative-pathology-educational-trust-2016-awards
#10
EDITORIAL
M J Day
No abstract text is available yet for this article.
November 15, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27817831/laboratory-controlled-challenges-of-nile-tilapia-oreochromis-niloticus-with-streptococcus-agalactiae-comparisons-between-immersion-oral-intracoelomic-and-intramuscular-routes-of-infection
#11
E Soto, M Zayas, J Tobar, O Illanes, S Yount, S Francis, M M Dennis
Streptococcus agalactiae, the aetiological agent of streptococcosis in fish, is an important pathogen of cultured and wild fish worldwide. To gain a better understanding of the pathogenesis of streptococcosis in Nile tilapia (Oreochromis niloticus), and to identify the experimental route of infection that most closely mimics natural disease, fingerlings were challenged with S. agalactiae utilizing different delivery methods. Fingerlings were challenged via intracoelomic injection (ICinj), intramuscular injection (IMinj), orally or by immersion with serial dilutions of S...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27780575/expression-kinetics-of-rantes-and-mcp-1-in-the-brain-of-deer-mice-peromyscus-maniculatus-infected-with-vesicular-stomatitis-new-jersey-virus
#12
L P Mesquita, F R P Bruhn, P C Maiorka, E W Howerth
The vesicular stomatitis virus (VSV) causes encephalitis in mice when inoculated intranasally. The deer mouse (Peromyscus maniculatus), a native New World rodent, is also susceptible to VSV infection and develops similar central nervous system (CNS) lesions to those observed in other rodent species. Chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES; CCL-5) and monocyte chemoattractant protein (MCP)-1 (CCL-2), which are important for chemotaxis and activation of inflammatory cells, are expressed during the course of VSV encephalitis...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27720131/disseminated-histiocytic-sarcoma-in-an-african-hedgehog-atelerix-albiventris
#13
K Ogihara, T Itoh, Y Mizuno, K Tamukai, H Madarame
Disseminated histiocytic sarcoma (HS) was diagnosed on post-mortem examination of a 1.5-year-old African hedgehog (Atelerix albiventris) that was presented in poor physical condition and with diarrhoea. Leucocytosis and a hypoechoic abdominal mass were noted on haematological and ultrasonographical examinations. Gross pathological, histopathological, immunohistochemical and ultrastructural evaluation of the mass supported a diagnosis of disseminated HS. To our knowledge, this report represents the first documentation of disseminated HS in this species...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27697284/infection-dynamics-of-foot-and-mouth-disease-virus-in-cattle-following-intranasopharyngeal-inoculation-or-contact-exposure
#14
J M Pacheco, C Stenfeldt, L L Rodriguez, J Arzt
For the purpose of developing an improved experimental model for studies of foot-and-mouth disease virus (FMDV) infection in cattle, three different experimental systems based on natural or simulated natural virus exposure were compared under standardized experimental conditions. Ante-mortem infection dynamics were characterized in cattle exposed to FMDV through a novel, simulated natural intranasopharyngeal (INP) inoculation system or through standardized and controlled systems of within- or between-species direct contact exposure (cattle-to-cattle or pig-to-cattle)...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27665042/high-grade-myxoid-liposarcoma-round-cell-variant-in-a-dog
#15
Q D Plumlee, A M Hernandez, S D Clark, A Bascuñán, J Davidson, J Mansell
A 10-year-old, neutered male, Basset hound had a 26 × 21 × 21 cm infiltrative mass on the left abdominal wall that did not extend into the peritoneal cavity based on radiographs and abdominal computed tomography. Cytological examination revealed moderate numbers of neoplastic round cells, which frequently contained numerous round, clear, cytoplasmic vacuoles. Histologically, the tumour was composed of two morphologically distinct cell populations forming a continuum of heterogeneously differentiated cells...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27658578/laryngeal-chondritis-in-sheep-in-iceland
#16
Ó G Sigurðardóttir, E Jörundsson, V Friðriksdóttir
Laryngeal chondritis is a chronic disease in sheep with low morbidity, high mortality and unresolved pathogenesis. The disease has been recognized recently in Iceland and affects both ewes and rams. Animals of different ages are affected, but lambs and yearlings predominate. The disease is seen in housed animals and most cases occur during the late winter months. We report the gross and microscopical findings in 45 cases of laryngeal chondritis in Icelandic sheep.
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27578524/clinical-cytological-histological-and-immunohistochemical-features-of-cutaneous-mast-cell-tumours-in-ferrets-mustela-putorius-furo
#17
L Vilalta, A Meléndez-Lazo, G Doria, A Ramis, L Solano-Gallego, J Pastor, J Martorell
Cutaneous mast cell tumours (cMCTs) are one of the most common cutaneous tumours in ferrets (Mustela putorius furo). However, limited information is available regarding cytological and histological features of these tumours and studies evaluating KIT expression are lacking in this species. The aims of this prospective study were to describe the most common clinical, cytological and histological features of cMCTs in ferrets and to compare the usefulness of different staining techniques in the diagnosis of these tumours in ferrets as well as evaluating KIT expression in neoplastic mast cells (MCs) by immunohistochemistry...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27567927/epithelial-cell-adhesion-molecule-expression-in-canine-tumours
#18
D H Thamm, D F Hayes, T Meuten, T Laver, D G Thomas
Epithelial cell adhesion molecule (EpCAM) is expressed in most human normal and neoplastic tissues of epithelial derivation and may have an association with tumour cell aggressiveness, a stem cell-like phenotype and clinical outcome. Antibody-based strategies for the targeting and capture of EpCAM-expressing tumour cells are showing promise, both as diagnostic tools and potential therapies. The aim of this study was to assess EpCAM expression in canine tumours. EpCAM expression was assessed in tumour cell lines via gene expression profiling and in formalin-fixed and paraffin wax-embedded tissues from canine carcinomas representing various anatomical sites by immunohistochemistry...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27567273/immunohistochemical-detection-of-pax8-and-napsin-a-in-canine-thyroid-tumours-comparison-with-thyroglobulin-calcitonin-and-thyroid-transcription-factor-1
#19
J A Ramos-Vara, C B Frank, D DuSold, M A Miller
Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling was compared with labelling for TTF-1, thyroglobulin and calcitonin in 114 canine proliferative thyroid lesions. All 81 follicular tumours expressed thyroglobulin and were negative for calcitonin; 79/81 (98%) of these tumours expressed TTF-1 and Pax8 and 60/81 (74%) expressed napsin A...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27567271/pneumonia-due-to-chlamydia-pecorum-in-a-koala-phascolarctos-cinereus
#20
J T Mackie, A K Gillett, C Palmieri, T Feng, D P Higgins
Chlamydiosis is a common infectious disease of koalas (Phascolarctos cinereus), but Chlamydia spp. have not yet been demonstrated to cause pneumonia in these animals. A juvenile male koala died following an episode of respiratory disease. At necropsy examination, the lung tissue was consolidated. Microscopical lesions in the lung included pyogranulomatous bronchopneumonia, proliferation of bronchiolar and alveolar epithelium and interstitial fibrosis. Hyperplastic bronchiolar epithelial cells contained aggregates of small basophilic punctate organisms, which were confirmed as chlamydiae by transmission electron microscopy and immunohistochemistry...
November 2016: Journal of Comparative Pathology
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