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Journal of Comparative Pathology

M J Day
No abstract text is available yet for this article.
November 10, 2017: Journal of Comparative Pathology
L Kruse Jensen, J Koch, N Lind Henriksen, M Bue, M Tøttrup, P Hanberg, K Søballe, H Elvang Jensen
Treatment of post-traumatic and implant-associated osteomyelitis (IAO) includes surgical debridement, removal of implants and long-term antibiotic therapy. The success of antibiotic therapy relies not only on activity towards the infecting pathogen, but also on sufficient penetration of the target site. The aim of the present study was to characterize the local pathological changes associated with reduced penetration of cefuroxime to infected bone implant cavities. Previously, reduced penetration of systemically administrated cefuroxime was demonstrated in the implant cavity of 10 pigs with Staphylococcus aureus IAO present for 5 days...
November 2017: Journal of Comparative Pathology
A N E Civello, B Dunkel, B A Summers, H M Martineau
A neurofibroma of granular cell subtype is described in a 7-year-old horse. The horse had a 3-month history of ataxia affecting the forelimbs and hindlimbs, suggesting a C1-C6 neuroanatomical localization. Post-mortem examination revealed an intradural mass arising from the right sixth cervical spinal nerve and compressing the spinal cord. Histologically, the mass was composed largely of wavy spindle cells (a mixture of Schwann cells, perineurial cells and fibroblasts) intimately associated with ropy collagen fibres...
November 2017: Journal of Comparative Pathology
K Koyama, N Horiuchi, H Hasegawa, H Katano, E Oohashi, K Watanabe, Y Kobayashi
Cytomegalic inclusion disease (CID) in the salivary gland of African hedgehogs (Atelerix arbiventris) has been reported before, and is suspected to reflect a cytomegalovirus infection. However, a recent ultrastructural study reported that African hedgehog CID reflected oncocytic metaplasia, mimicking a cytomegalovirus infection. We examined the submandibular and sublingual salivary glands of a 1-year-old male African hedgehog. Histologically, there were multiple foci composed of cytomegalic cells with intranuclear inclusion bodies...
November 2017: Journal of Comparative Pathology
D-M Go, S-H Lee, S-H Woo, D-Y Kim
A 12-year-old female miniature schnauzer and a 12-year-old neutered female cocker spaniel each had a grey-yellow nodular lesion arising from the gingiva. Microscopical examination showed that both nodules were composed of varied proportions of sebocytes and basal-type reserve cells with few ducts lined by stratified squamous epithelium. Based on the histopathological findings, the cases were diagnosed as sebaceous adenoma and sebaceous epithelioma, respectively. In man, the occurrence of sebaceous neoplasms in the oral cavity has been reported to some extent, but these lesions are very rare in animals...
November 2017: Journal of Comparative Pathology
B Banco, R Ferrari, D Stefanello, D Groppetti, A Pecile, S Faverzani, M Longo, D D Zani, G Ravasio, M Caniatti, V Grieco
A 17-month-old female doberman pinscher was referred for an abdominal mass and ascites. Exploratory laparotomy revealed the presence of a large neoplastic mass replacing the right ovary and associated with multiple mesovarian, mesometrial and peritoneal nodules. An ovariohysterectomy was performed. Grossly, the tumour was soft and multilocular with large areas of haemorrhage and necrosis. Microscopically, it was infiltrative and composed of round and polygonal cells arranged respectively in solid sheets or forming distorted tubular structures separated by thick fibrovascular septae...
November 2017: Journal of Comparative Pathology
T L Wright, D Eshar, J W Carpenter, D Lin, A Padmanabhan, L Peddireddi, G Cino
Hepatocellular carcinomas are the most commonly reported neoplasm of black-tailed prairie dogs (Cynomys ludovicianus). In several other closely related Sciuridae species, infection with species-specific hepadnaviruses is associated with the development of these tumours, but such a hepadnavirus has not yet been identified in any prairie dog species, although its presence has been hypothesized previously. An adult prairie dog was humanely destroyed due to progressive illness and the identification of a cranial abdominal mass that was determined on histopathology to be a hepatocellular carcinoma...
November 2017: Journal of Comparative Pathology
G Paraschou, A Suárez-Bonnet, V Grove, S L Priestnall
A peripheral nerve sheath tumour, with features of a benign schwannoma and arising from the endocardium of the right ventricle, was found incidentally during routine post-mortem examination of a 28-year-old gelding donkey. Macroscopically, five round to oval, white to grey and red, firm masses, firmly attached to the endocardium were identified. Microscopically, the endocardium and adjacent subendocardium were infiltrated by a variably demarcated, non-encapsulated mesenchymal neoplasm with features of a benign schwannoma, including concurrent presence of Antoni A and Antoni B areas, nuclear palisading, neoplastic cells with enlarged bizarre nuclei ('ancient change') and the formation of Verocay-like bodies...
November 2017: Journal of Comparative Pathology
J M Monné Rodríguez, J Chantrey, S Unwin, R Verin
This case report describes congenital truncus arteriosus in a 1-month-old Eastern black rhinoceros (Diceros bicornis michaeli). From the first day of life the animal was underweight and from the 22nd day of life displayed respiratory signs that exacerbated with time leading eventually to collapse and death. Post-mortem examination revealed a single truncus arteriosus originating from the right ventricle leading to two separated pulmonary arteries and the aorta, with the ventricular septum showing a focal communicating defect...
November 2017: Journal of Comparative Pathology
D Buxton, H W Reid
No abstract text is available yet for this article.
November 2017: Journal of Comparative Pathology
K Hagiwara, M Michishita, H Yoshimura, K Ochiai, D Azakami, T Ishiwata, K Takahashi
A 21-year-old neutered female domestic shorthaired cat was presented with a history of inappetence, vomiting and haematuria. The cat was humanely destroyed at the owner's request and a necropsy examination was performed. A 0.8 × 0.5 × 0.5 cm mass was located in the left lobe of the pancreas. The mass was gelatinous in nature and the external and cut surfaces were pale yellow in colour. Microscopically, the mass was non-capsulated and comprised an accumulation of extracellular stromal mucin containing suspended neoplastic columnar epithelial cells forming tubular structures...
November 2017: Journal of Comparative Pathology
A A Al-Khan, H J Gunn, M J Day, M Tayebi, S D Ryan, C A Kuntz, E S Saad, S J Richardson, J A Danks
Osteosarcoma (OS) originates from bone-forming mesenchymal cells and represents one of the primary bone tumours. It is the most common primary bone tumour in dogs and man. The characterization of an appropriate natural disease animal model to study human OS is essential to elucidate the pathogenesis of the disease. This study aimed to validate canine OS as a model for the human disease by evaluating immunohistochemically the expression of markers known to be important in human OS. The immunohistochemical panel included vimentin, alkaline phosphatase (ALP), desmin, S100, neuron-specific enolase (NSE), runt-related transcription factor 2 (Runx2) and bone morphogenetic protein 4 (BMP4)...
November 2017: Journal of Comparative Pathology
M P Dagleish, P G Ryan, S Girling, M Ghazali, A L Bond
The Gough moorhen (Gallinula comeri) is native to Gough Island, Tristan da Cunha, and listed as Vulnerable by the International Union for Conservation of Nature due to its restricted range and susceptibility to introduced predators. A planned ecosystem restoration by eradication of introduced house mice (Mus musculus) via aerially delivered rodenticide requires a reproductively balanced population of Gough moorhens to be held in captivity to avoid primary and secondary poisoning. To aid disease detection during the period of captivity, Gough moorhens (n = 43; 25 adult females and 18 adult males) were captured, measured and sampled to determine ease of sexing by morphometrics, to establish reference ranges for routine haematological and biochemical parameters and to identify any intestinal and haemoparasites as well as determine which faecal bacteria were present...
November 2017: Journal of Comparative Pathology
Kikumi Ogihara, Kaoru Suzuki, Hiroo Madarame
A 2.5-year-old African hedgehog (Atelerix albiventris) with signs of progressive paresis/paralysis for approximately 6 months was diagnosed with 'wobbly hedgehog syndrome' (WHS). Post-mortem examination revealed a primary central nervous system (CNS) histiocytic sarcoma (HS) associated with neurodegenerative changes of the CNS and skeletal muscle atrophy. Grossly, a spherical mass infiltrated the left forebrain and was located between the frontal lobe and thalamus in coronal sections. Microscopically, the neoplastic cells had eccentrically located anisokaryotic nuclei and abundant eosinophilic cytoplasm...
November 2017: Journal of Comparative Pathology
D S Russell, K L Townsend, E Gorman, S Bracha, K Curran, M Milovancev
Stromal invasion is identified commonly in cutaneous malignancies; however, invasive patterns are defined inconsistently and their clinical relevance is uncertain. This study aimed to define objective, quantifiable histomorphological invasive patterns in low-grade canine mast cell tumours (MCTs) and grade I/II soft tissue sarcomas (STSs), and correlate invasive patterns with overall excisional status. Haematoxylin and eosin-stained glass slides prepared for routine histopathology of surgically-excised tumours from client-owned dogs were evaluated for invasion beyond their subgross edge, asymmetrical invasion, satellite lesions, lymphovascular invasion, perineurovascular growth, growth along fascial planes, intramuscular invasion and multicompartmental involvement...
November 2017: Journal of Comparative Pathology
J N Winer, B Arzi, S Döring, P H Kass, F J M Verstraete
Museum specimens (maxillae and mandibles) from 393 North American brown bears (Ursus arctos) from Alaska were examined macroscopically according to predefined criteria and 204 specimens were included in this study. The specimens were acquired between 1905 and 2012. There were 99 specimens (48.5%) from male animals, 87 (42.7%) from female animals and 18 (8.8%) from animals of unknown sex. The ages of the animals ranged from neonate to adult, with 92 adults (45.1%) and 112 young adults (54.9%) included and neonates/juveniles excluded from the study...
August 2017: Journal of Comparative Pathology
A Suárez-Bonnet, E Rodríguez Grau-Bassas, P Herráez, O Quesada-Canales, S L Priestnall, A Espinosa de Los Monteros
Naturally occurring mammary tumours are uncommon in prosimians. A 20-year-old female ring-tailed lemur (Lemur catta) developed bilateral enlargement of the mammary glands. Surgical removal revealed that both masses were comprised of multiple nodules and cystic areas that entirely replaced the normal glands. Histologically, a benign neoplastic biphasic cellular proliferation, composed of luminal-epithelial and basal-myoepithelial components, was identified. Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm...
August 2017: Journal of Comparative Pathology
A A Ahmad, G M Dorrestein, S J W Y Oh, C D Hsu
A 38-year-old Malayan gharial (Tomistoma schlegelii) with a 2-week history of anorexia was found dead and presented for post-mortem examination. Numerous white firm nodules of various sizes were found on the surface of the liver, both left and right kidneys, the spleen and the serosa of the intestinal tract. All masses had similar microscopical appearance and were diagnosed as metastasizing fibrolamellar hepatocellular carcinoma. Immunohistochemically, the tumour cells did not react with antibodies specific for pan-cytokeratin, vimentin or HepPar-1...
August 2017: Journal of Comparative Pathology
A L Martino-Costa, F Malhão, C Lopes, P Dias-Pereira
Chronic kidney disease (CKD) is a common progressive condition described in dogs and cats, involving several non-specific morphological and histological lesions. Recently, renal interstitial lipid accumulation was reported in cats with CKD; however, to date, little is known about this condition and its pathogenesis. The aim of this study was to investigate the occurrence and to characterize renal interstitial lipid deposits in dogs and cats. A total of 49 animals (27 cats and 22 dogs) with CKD were included in the study...
August 2017: Journal of Comparative Pathology
S-H Lee, D-M Go, S-H Woo, H-T Park, E Kim, H S Yoo, D-Y Kim
A 1-year-old, female domestic shorthair cat was presented with anorexia, depression and weight loss, accompanied by multifocal nodules affecting the face, pinnae and periarticular tissue. Routine medical treatments were ineffective. The animal's physical condition continued to deteriorate and it finally died. Post-mortem examination revealed multifocal to coalescing firm nodules with occasional ulceration affecting the ears, peri-ocular areas, nasal planum, oral cavity and laryngopharyngeal region. Tan-coloured, firm, nodular lesions were also observed in the periarticular tissue, lungs and tracheobronchial and mediastinal lymph nodes...
August 2017: Journal of Comparative Pathology
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