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Journal of Comparative Pathology

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https://www.readbyqxmd.com/read/28433396/lambs-are-susceptible-to-experimental-challenge-with-spanish-goat-encephalitis-virus
#1
L M Salinas, R Casais, J F García Marín, K P Dalton, L J Royo, A Del Cerro, E Gayo, M P Dagleish, R A Juste, A Balseiro
Spanish goat encephalitis virus (SGEV) is a member of the genus Flavivirus, family Flaviviridae, and causes encephalomyelitis in goats. The aim of this study was to determine whether sheep are susceptible to experimental challenge with SGEV by two different routes. The results show that SGEV can infect sheep by both the subcutaneous and intravenous routes, resulting in neurological clinical disease with extensive and severe histological lesions in the central nervous system. Lambs challenged subcutaneously developed more severe lesions on the ipsilateral side of the brain, but the lesion morphology was similar irrespective of the route of challenge...
April 19, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28431735/characterization-of-an-amyloid-only-transgenic-b6c3-tg-appswe-psen1de9-85dbo-mmjax-mouse-model-of-alzheimer-s-disease
#2
G S Finnie, R Gunnarsson, J Manavis, P C Blumbergs, K A Mander, S Edwards, C Van den Heuvel, J W Finnie
The spatiotemporal pattern of cerebral amyloid deposition, detectable as light microscopically recognizable aggregates in an 'amyloid only' transgenic mouse model of Alzheimer's disease, B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax, is reported for the first time in this strain. Monoclonal and polyclonal antibodies were used to detect amyloid deposition immunohistochemically in brains collected from these mice at 3-12 months of age. Amyloid aggregates (20-200 μm) were first found in serial, whole coronal sections of brain at 4 months of age and these increased progressively, plateauing at 11-12 months...
April 18, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28427752/spontaneously-arising-tumours-and-tumour-like-lesions-of-the-cervix-and-uterus-in-83-pet-guinea-pigs-cavia-porcellus
#3
C Laik-Schandelmaier, R Klopfleisch, S Schöniger, G Weiffenbach, M Staudacher, H Aupperle
Tumours and tumour-like lesions are rare findings in the genital system of guinea pigs. The aim of the present study was to characterize nodular lesions in the cervix and uterus of guinea pigs submitted for histopathological diagnosis. Samples from 83 pet animals were investigated. Cases included 64 surgically excised masses including complete uteri (n = 37), parts from uteri containing masses (n = 8), complete masses (n = 12) or samples from masses (n = 7) and 19 complete necropsy examinations. In 55 of the cases, only solitary changes were observed; in 28 cases two or more lesions were diagnosed...
April 17, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28408040/myxomatous-degeneration-of-the-canine-mitral-valve-from-gross-changes-to-molecular-events
#4
REVIEW
G Markby, K M Summers, V E MacRae, J Del-Pozo, B M Corcoran
Myxomatous mitral valve disease (MMVD) is the single most common acquired heart disease of the dog, but is also of emerging importance in human medicine, with some features of the disease shared between both species. There has been increased understanding of this disease in recent years, with most research aiming to elucidate the cellular and molecular events of disease pathogenesis. For gross and histological changes, much of our understanding is based on historical studies and there has been no comprehensive reappraisal of the pathology of MMVD...
April 10, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28391972/neuroaxonal-dystrophy-in-a-flock-of-pied-imperial-pigeons-ducula-bicolor
#5
M Barrows, R Killick, C Day, R Saunders, K Baiker, L Ressel, D Denk
Five juvenile pied imperial pigeons (Ducula bicolor) presented with neurological signs including torticollis, ataxia and poor flying ability. All were humanely destroyed and submitted for post-mortem examination. Microscopically, the most significant findings were in the brain and spinal cord. Spheroid formation was evident within the medulla, pons, diencephalon, cortical grey and subcortical white matter, spinal cord white and grey matter and the granular and molecular cell layers of the cerebellum. There was no evidence of associated inflammation...
April 6, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28385336/association-between-pancreatitis-and-immune-mediated-haemolytic-anaemia-in-cats-a-cross-sectional-study
#6
A Zoia, M Drigo
In most cases, the underlying causes of feline pancreatitis and feline immune-mediated haemolytic anaemia (IMHA) remain unknown. Following the observation that some cats present with both diseases concurrently, the aim of this cross-sectional study was to investigate if the two disorders were associated statistically in this species. A residency case log of all cases seen at the Small Animal Hospital, University of Glasgow, Glasgow, UK, between July 2004 and December 2007, was used as the database for this study and an association between these two disorders was assessed by Fisher's exact test...
April 3, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28320532/atypical-histiocytosis-in-red-squirrels-sciurus-vulgaris
#7
S H Smith, K Stevenson, J Del-Pozo, S Moss, A Meredith
Four red squirrels (Sciurus vulgaris) were subjected to necropsy examination over a 3-year period as part of a broader surveillance study. The squirrels presented with cutaneous, subcutaneous and/or internal swellings and nodules that consisted microscopically of sheets of atypical round cells and multinucleated giant cells. There was moderate anisokaryosis with rare mitoses. Nuclei ranged from oval to indented or C-shaped and some were bizarre, twisted or multilobulated. Many giant cells also had a bizarre morphology, with anisokaryosis within individual cells...
March 17, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28318536/chromobacterium-violaceum-infection-in-a-horse
#8
Márcia Elisa Hammerschmitt, Veronica Machado Rolim, Gustavo Geraldo Medina Snel, Franciele Maboni Siqueira, David Driemeier, Saulo Petinatti Pavarini
Chromobacterium violaceum is an opportunistic pathogen of mammals that produces characteristic violet pigment in bacterial culture. We report pneumonia and septicaemia caused by C. violaceum in a horse. Necropsy examination was performed on a 3-year-old Quarter Horse stallion with a history of recurrent episodes of pneumonia, fever, dyspnoea and sanguineous nasal discharge. The lungs were not collapsed, but they contained dark red foci mixed with white areas, and multiple nodules of firm consistency. Within the liver and kidney there were randomly distributed, multifocal, white pinpoint lesions (0...
March 16, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28284556/morphology-and-morphometry-of-the-lung-in-corn-snakes-pantherophis-guttatus-infected-with-three-different-strains-of-ferlavirus
#9
J M Starck, A Neul, V Schmidt, T Kolb, S Franz-Guess, D Balcecean, M Pees
Ophidian paramyxovirus (ferlavirus) is a global threat to reptilian sauropsids in herpetological collections, with occasional but fatal effects. This study characterizes the effects of three different genetic strains of ferlavirus on the dynamic changes of histology and morphometry of the lung of corn snakes (Pantherophis guttatus). Lungs from 42 corn snakes were either sham-infected or infected experimentally under standardized conditions. From 4 to 49 days after intratracheal inoculation, the lungs were examined qualitatively and quantitatively...
March 8, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28258732/immunohistochemical-expression-of-placental-alkaline-phosphatase-in-five-cases-of-seminoma-in-rabbits
#10
B Banco, J Ferreira da Silva, S Cotti Cometti, D Stefanello, V Grieco
Testicular seminoma is reported in the rabbit but data about the immunophenotype of these tumours are lacking. The classification of human testicular germ cell tumours includes spermatocytic tumour (ST) originating from the post-pubertal spermatogonia/spermatocytes, which metastasizes rarely, and seminoma (SE), originating from gonocytes, which is malignant and metastasizes frequently. Gonocytes express placental alkaline phosphatase (PLAP) and are stained with periodic acid-Schiff (PAS). We report five cases of seminoma in pet rabbits...
February 28, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28238470/fatal-salmonellosis-in-captive-maras-dolichotis-patagonum-caused-by-salmonella-enteritidis
#11
S Nakamura, Y Yoshimura, H Hayashidani, T Iwata, S Iseda, Y Une
We report epidemic occurrences of fatal salmonellosis caused by Salmonella Enteritidis in captive maras (Dolichotis patagonum) in a zoological garden in Japan. The deaths were sudden or followed a peracute course within a few hours of the first observations of clinical abnormalities. Gross lesions included haemorrhages in the subcutis and skeletal muscles, liver, spleen, lung, heart and gastrointestinal tract. Microscopically, there were haemorrhagic and necrotizing lesions with gram-negative bacilli in the liver, spleen, small intestine and Peyer's patches...
February 23, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28233523/mycobacterial-arthritis-and-synovitis-in-painted-reed-frogs-hyperolius-marmoratus
#12
M Barrows, K Koeppel, A Michel, E Mitchell
Several species of atypical mycobacteria have been isolated from wild and captive amphibians. In captive anurans, cutaneous and visceral mycobacteriosis are common and can result in significant mortality, particularly when animals are immunocompromised. Mycobacterial arthritis and synovitis are reported rarely in amphibians. We describe 20 cases in painted reed frogs (Hyperolius marmoratus), which presented with cachexia, limb paresis or paralysis or 'spindly leg syndrome'. Histopathology revealed multifocal histiocytic to granulomatous synovitis affecting appendicular, rib or spinal intervertebral joints...
February 20, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28233522/comparison-of-clinical-and-pathological-diagnoses-in-cats-and-dogs
#13
T I Schertenleib, A Pospischil, M Hässig, P R Kircher, M Hilbe
The comparison of clinical ante-mortem and pathological post-mortem diagnoses is a prerequisite for quality control, but is rarely done in veterinary medicine. This study reports the occurrence and concurrence of clinical and pathological diagnoses linked to death in 1,000 cats and 1,000 dogs examined and subjected to necropsy examination at the University of Zurich, Switzerland. Potential factors influencing the correlation between diagnoses were examined retrospectively. In 5.8% of cats and 5.2% of dogs no diagnosis was made; in 2...
February 20, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28238305/polyomavirus-infection-in-gouldian-finches-erythrura-gouldiae-and-other-pet-birds-of-the-family-estrildidae
#14
E Circella, A Caroli, M Marino, M Legretto, N Pugliese, G Bozzo, G Cocciolo, D Dibari, A Camarda
A syndrome characterized by apathy, diarrhoea and high mortality of nestlings was observed in a flock of pet birds of the family Estrildidae. Enlargement of the liver, pulmonary congestion and urate accretions in the kidney were observed. Microscopically, there was glomerular atrophy, oedema and congestion of the lungs and necrosis and fibrosis of the liver. Cowdry type B intranuclear inclusion bodies were detected in the tissues. Polyomavirus was detected by polymerase chain reaction. The entire genome of the virus was amplified and sequenced, revealing 99 % identity to the sequence of finch polyomavirus isolated from the Eurasian bullfinch (family Fringillidae)...
February 18, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28213989/the-post-mortem-examination-in-ruminants-and-its-possible-benefit-to-ruminant-clinical-medicine
#15
K Wäsle, A Pospischil, M Hässig, C Gerspach, M Hilbe
To highlight the important role of post-mortem examination of ruminants and to identify possible benefits for modern ruminant medicine, a comparison of clinical and pathological diagnoses was conducted and influencing factors were identified. For this purpose, results from 2,000 ruminants that had undergone necropsy examination at the University of Zurich, Switzerland, were analysed retrospectively. Both clinical and pathological diagnoses were available for 81.40% of cattle, 80.22% of sheep and 66.66% of goats; no diagnoses were available for 3...
February 14, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28196645/oral-squamous-cell-carcinoma-in-three-related-kowari-dasyuroides-byrnei
#16
Richard Saunders, Rowena Killick, Michelle Barrows, Mark Stidworthy
We report three kowari (Dasyuroides byrnei) with squamous cell carcinoma affecting the gingiva. These cases occurred in rapid succession in a related group of individuals of similar age, suggesting a familial tendency to this condition and a typical age of presentation. Other conditions affecting the oral cavity can mimic the appearance of oral squamous cell carcinoma in this species, and so knowledge of this condition can assist the veterinarian in making rapid decisions regarding prognosis and improving the welfare of these animals...
February 11, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28185624/clinical-pathology-of-the-critically-endangered-gough-bunting-rowettia-goughensis
#17
M P Dagleish, P G Ryan, S Girling, A L Bond
The Gough bunting (Rowettia goughensis) is indigenous to Gough Island and critically endangered due to predation by invasive house mice (Mus musculus). A planned ecosystem restoration by eradication of house mice via aerially delivered rodenticide requires a reproductively balanced population of Gough buntings being held in captivity to avoid primary and secondary poisoning. To aid disease detection during the period of captivity, Gough buntings (n = 25; five adult females, 15 adult males and five juveniles) were captured, measured and sampled to determine reference ranges for routine haematological and biochemical parameters and to identify any faecal bacterial species and intestinal and haemoparasites...
February 6, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28161098/peracute-bacterial-meningitis-due-to-infection-with-klebsiella-pneumoniae-in-captive-bred-ruffed-lemurs-varecia-variegate
#18
E Sasaki, T Tokiwa, K Tsugo, Y Higashi, H Hori, Y Une
We describe the development of neurological signs in four juvenile black-and-white ruffed lemurs (Varecia variegate), housed at a petting zoo in Japan. The clinical course was severe, with three lemurs dying within 1 day of the appearance of clinical signs. The other lemur was treated and survived. Pathological analyses demonstrated meningitis and the presence of gram-negative bacilli in the cerebrum, cerebellum, palatine tonsil and liver. Klebsiella pneumoniae was isolated from the brain of all of the dead lemurs...
February 1, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28089357/localization-of-toll-like-receptor-tlr-2-and-tlr4-mrna-in-the-colorectal-mucosa-of-miniature-dachshunds-with-inflammatory-colorectal-polyps
#19
N Yokoyama, H Ohta, J Yamazaki, Y Kagawa, O Ichii, N Khoirun, T Morita, T Osuga, S Y Lim, N Sasaki, K Morishita, K Nakamura, M Takiguchi
Inflammatory colorectal polyps (ICRPs) are characterized by the formation of multiple or solitary polyps with marked neutrophil infiltration in the colorectal area, and are speculated to be a novel form of breed-specific canine idiopathic inflammatory bowel disease (IBD). In human IBD, toll-like receptor (TLR) 2 and TLR4 have been reported to be involved in the pathogenesis of the disease. The aim of this study was to evaluate the expression of TLR2 and TLR4 mRNA in the colorectal mucosa of dogs with ICRPs by in-situ hybridization using an RNAscope assay...
January 12, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28087057/120-years-of-tuberculosis-research-an-historical-perspective-from-the-archive-of-the-journal-of-comparative-pathology
#20
EDITORIAL
S Kennedy
No abstract text is available yet for this article.
January 10, 2017: Journal of Comparative Pathology
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