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Journal of Comparative Pathology

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https://www.readbyqxmd.com/read/30213375/expression-of-stem-cell-factor-in-feline-mast-cell-tumour
#1
M Sakurai, R Iwasa, Y Sakai, J K Chambers, K Uchida, M Morimoto
Stem cell factor (SCF) is a ligand of the molecule Kit, which is expressed in mast cells and is important for mast cell proliferation, migration and survival. Mast cell tumours (MCTs) are associated with mutations of c-kit, a proto-oncogene encoding the Kit protein. In this study, we examined SCF expression in 23 samples of feline MCTs. SCF expression was detected in 10 cutaneous MCTs and a case of splenic mastocytosis. In the cutaneous MCTs, SCF-positive tumour cells were located at the margins. Kit was expressed in eight of the 10 cutaneous cases of SCF-expressing MCTs...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213374/the-journal-of-comparative-pathology-educational-trust-and-petplan-charitable-trust-joint-research-award-in-veterinary-pathology
#2
EDITORIAL
M J Day
No abstract text is available yet for this article.
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213373/metaphyeal-and-diaphyseal-dysplasia-of-the-third-cervical-vertebra-secondary-to-physeal-necrosis-in-a-quarter-horse-foal
#3
C Yang, S Weisbrode, J Yardley, E Schroeder, C Premanandan
Ischaemia-induced physeal injury has not been described previously in the horse. A 1-month-old Quarter horse foal was submitted for necropsy examination due to an acute onset of ataxia followed by a 4-week history of progressive decline. Focal narrowing of the spinal canal due to ventral compression by the rotation of the cranial aspect of the third cervical vertebra (C3) was observed. The metaphysis and diaphysis of C3 were markedly shortened and white-tan in colour. Microscopically, there was complete loss of the dorsal compact bone of C3 and replacement of 80% of the physis that runs parallel to the vertebral canal with fibrous tissue and thickened viable trabecular bone...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213372/sympathetic-innervation-and-adrenergic-receptors-in-equine-deep-digital-flexor-tendinopathy-preliminary-results
#4
F Beccati, M Pepe, L Antinori, L Pascucci, E Chiaradia, M T Mandara
The aim of this study was to delineate the pattern of sympathetic innervation in the suprasesamoidean region of the deep digital flexor tendon (DDFT) in horses with tendinopathy by immunohistochemical labelling for tyrosine hydroxylase (TH) and α-1 adrenergic receptor (α1-AR). Twelve forelimbs were obtained from 10 horses with DDFT tendinopathy and six feet obtained from six horses were used as healthy controls. Post-mortem radiographic, ultrasonographic and gross examinations were performed on the suprasesamoidean area of the DDFT to assess the presence of tendinopathy...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213371/ganglioneuromatosis-of-the-gallbladder-in-a-dog-with-cholecystitis-and-cholestasis
#5
G A Ramírez, J Altimira, M Vilafranca
A 2-year-old entire female mixed-breed dog was presented with signs of cholestasis. Abdominal ultrasonography revealed a gallbladder with a thickened and hyperechoic wall and luminal calculi. Exploratory laparotomy with cholecystectomy was performed and histopathological examination of the specimens from the cholecystectomy demonstrated extensive proliferation of large, prominent nerves containing ganglion cells with no atypia mainly located in the gallbladder mucosa. The neural nature of these components was confirmed by immunohistochemical labelling with antibodies specific for synaptophysin, glial fibrillary acidic protein, S100 protein and neurofilaments...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213370/complex-gill-disease-an-emerging-syndrome-in-farmed-atlantic-salmon-salmo-salar-l
#6
A Herrero, K D Thompson, A Ashby, H D Rodger, M P Dagleish
Gill disorders have become a significant problem during the marine phase of farming Atlantic salmon (Salmo salar L.). The term complex gill disease (CGD) includes a wide range of clinical gill disease presentations generally occurring from the end of summer to early winter on marine Atlantic salmon farms. The gross and histological lesions observed are the resultant culmination of exposure to a mixture of environmental insults, pathogenic organisms and farm management practices. None of the three principal agents purportedly associated with CGD (Desmozoon lepeophtherii, salmon gill poxvirus or Candidatus Branchiomonas cysticola) have been cultured successfully in-vitro, so individual in-vivo challenge studies to identify their pathogenesis have not been possible...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213369/computerized-cytomorphometric-and-cytomorphological-analysis-of-canine-transmissible-venereal-tumours
#7
C Setthawongsin, S Tangkawattana, A Rungsipipat, S Techangamsuwan
Canine transmissible venereal tumour (CTVT) has three cytomorphological types: plasmacytic, lymphocytic and mixed type. Cytomorphometry, a method of computerized image analysis, has been used recently in veterinary medicine. This study compared the nuclear and cellular morphometric parameters (i.e. radius, diameter, perimeter and area) in different types of CTVT with other canine round cell tumours including lymphoma, mast cell tumour (MCT) and histiocytic tumour (HCT). We also evaluated the relationship between clinical information and the different CTVT cytomorphologic types...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213368/oral-and-dental-examination-findings-in-beech-martens-martes-foina
#8
K Slabá, B Kryštufek, A Nemec
Detailed clinical and radiographical descriptions of oral/dental pathology in the beech marten (Martes foina) are lacking. In the present study, skulls of M. foina from a museum collection (n = 109) were examined macroscopically according to predefined criteria and full-mouth dental radiographs were obtained. Occlusion was diagnosed as 'scissor bite' in 22.5% of evaluated skulls, 77% of evaluated skulls showed 'level bite' of incisors and 9.2% of evaluated skulls had 'open bites'. In three skulls, class III malocclusion was diagnosed...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30213367/feline-injection-site-sarcomas-data-from-switzerland-2009-2014
#9
R Graf, F Guscetti, M Welle, D Meier, A Pospischil
Feline injection site sarcomas (FISS) were first described in the early 1990s. Despite extensive research, the pathogenesis of these tumours has not been elucidated conclusively. Their appearance and the marked increase in their incidence has been mainly connected to the injection of vaccines, and it is assumed that a chronic inflammatory reaction at the injection site triggers subsequent malignant transformation. The role of alum-based adjuvants has been discussed, but is controversial. The present study of the Swiss Feline Cancer Registry (SFCR) with data from 2009 to 2014 revealed a marked decrease of the incidence of fibrosarcomas compared with the previous observation period...
August 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060844/expression-of-oestrogen-receptor-progesterone-receptor-and-akt-in-canine-circumanal-gland-tumours
#10
S-H Kim, B-J Seung, S-H Cho, H-Y Lim, J-H Hwang, J-H Sur
We investigated the expression of oestrogen receptor alpha (OR-α), progesterone receptor (PR) and Akt in canine circumanal gland tumours. Immunohistochemistry was conducted on seven normal circumanal glands, 30 circumanal gland adenomas and 40 circumanal gland carcinomas. The expression of OR-α and PR was significantly lower in circumanal gland carcinomas than in circumanal gland adenomas. In contrast, the expression of Akt was markedly higher in circumanal gland carcinomas than in circumanal gland adenomas...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060843/altered-nuclear-expression-of-the-deubiquitylase-bap1-cannot-be-used-as-a-prognostic-marker-for-canine-melanoma
#11
N Jama, N Farquhar, Z Butt, S E Coupland, J J Sacco, T Scase, A B Fielding, J M Coulson, H Kalirai, D R Killick
BRCA1-associated protein-1 (BAP1) is a nuclear localized deubiquitylating enzyme that belongs to the ubiquitin c-terminal hydrolase subfamily. The encoded protein is highly homologous between man and dogs, suggesting a functional significance preserved by evolution. BAP1 has multiple properties, including tumour suppressor activity. Loss of BAP1 function is implicated in the oncogenesis of several types of cancers including uveal, mucosal and some cutaneous melanomas in humans, as well as in mesothelioma. In this study we investigate the significance of BAP1 in canine melanoma...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060842/diffuse-infiltrative-colonic-lipomatosis-in-a-vietnamese-pot-bellied-pig
#12
A Kokosinska, D R Rissi
Diffuse infiltrative gastrointestinal lipomatosis (DIGIL) is characterized by widespread proliferation of adipose tissue within the submucosal and subserosal layers of the gastrointestinal tract. Here we describe a case of diffuse infiltrative colonic lipomatosis in a 3-year-old male Vietnamese pot-bellied pig. Gross anatomical changes included obesity with sparse small intestinal contents and no colonic contents. The colonic lumen was narrowed and the colonic wall was diffusely thickened (∼5 mm), white, homogeneous and soft...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060841/evidence-of-vasculogenic-mimicry-in-a-palpebral-melanocytoma-in-a-dog
#13
L Nordio, S Fattori, M Vascellari, C Giudice
A 7-year-old neutered female Doberman pinscher was presented with a palpebral nodule on the haired eyelid of the left eye. The nodule was removed surgically. Microscopically, the nodule was consistent with eyelid melanocytoma. The tumour was characterized by the presence of numerous lacunar and slit-like spaces filled by erythrocytes and interspersed throughout the neoplastic melanocytes. Immunohistochemically, these spaces were lined by cells expressing PNL2 and factor VIII, but the cells were negative for CD31...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060840/bartonella-spp-as-a-possible-cause-or-cofactor-of-feline-endomyocarditis-left-ventricular-endocardial-fibrosis-complex
#14
T A Donovan, N Balakrishnan, I Carvalho Barbosa, T McCoy, E B Breitschwerdt, P R Fox
Endomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scratch disease in man. Various Bartonella spp. have been associated with culture-negative endocarditis, myocarditis and sudden death in man and animals. We hypothesized that Bartonella spp. DNA could be amplified more often from the hearts of cats with feline endomyocarditis-left ventricular endocardial fibrosis (FEMC-LVEF) complex compared with cats with hypertrophic cardiomyopathy (HCM) or cats with grossly and microscopically unremarkable hearts (designated non-cardiac disease controls)...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060839/comparative-neuropathology-of-major-indian-bluetongue-virus-serotypes-in-a-neonatal-balb-c-mouse-model
#15
A Anjaneya, K P Singh, S Cherian, M Saminathan, R Singh, M A Ramakrishnan, S Maan, N S Maan, D Hemadri, P P Rao, K Putty, Y Krishnajyothi, P P Mertens
Bluetongue virus (BTV) is neurotropic in nature, especially in ruminant fetuses and in-utero infection results in abortion and congenital brain malformations. The aim of the present study was to compare the neuropathogenicity of major Indian BTV serotypes 1, 2, 10, 16 and 23 by gross and histopathological lesions and virus distribution in experimentally infected neonatal BALB/c mice. Each BTV serotype (20 μl of inoculum containing 1 × 105 tissue culture infectious dose [TCID]50 /ml of virus) was inoculated intracerebrally into 3-day-old mice, while a control group was inoculated with mock-infected cell culture medium...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060838/histocytic-like-atypical-mast-cell-tumours-in-horses
#16
A Elbahi, A Kipar, L Ressel
This report describes a series of four equine mast cell tumours (MCTs) with atypical morphological features. The tumours were 1-2 cm in diameter and mostly localized to the eyes (one eyelid, two conjunctiva). Histologically, they were composed of very large (up to 35 μm) round pleomorphic cells with a large central to paracentral nucleus and abundant granular cytoplasm. A large number of viable mature eosinophils were detected intermingled with the large round cells. Histochemical staining (toluidine blue and Perls' Prussian blue) and immunohistochemistry (KIT, mast cell tryptase, lysozyme and proliferating cell nuclear antigen) confirmed the mast cell origin of the atypical cells and identified an aberrant KIT protein expression in three cases...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30060837/distribution-of-connective-tissue-in-the-male-and-female-porcine-liver-histological-mapping-and-recommendations-for-sampling
#17
P Mik, Z Tonar, A Malečková, L Eberlová, V Liška, R Pálek, J Rosendorf, M Jiřík, H Mírka, M Králíčková, K Witter
The pig is a large animal model that is often used in experimental medicine. The aim of this study was to assess, in normal pig livers, sexual dimorphism in the normal fraction of hepatic interlobular and intralobular connective tissue (CT) in six hepatic lobes and in three macroscopical regions of interest (ROIs) with different positions relative to the liver vasculature. Using stereological point grids, the fractions of CT were quantified in histological sections stained with aniline blue and nuclear fast red...
July 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30173858/the-temporomandibular-joint-of-the-domestic-dog-canis-lupus-familiaris-in-health-and-disease
#18
A W Lin, N Vapniarsky, D D Cissell, F J M Verstraete, C H Lin, D C Hatcher, B Arzi
This study aimed to characterize the histological, biomechanical and biochemical properties of the temporomandibular joint (TMJ) of the domestic dog in health and disease. In addition, we sought to identify structure-function relationships and to characterize TMJ degenerative lesions that may be found naturally in this species. TMJs (n = 20) from fresh cadaver heads (n = 10) of domestic dogs were examined macroscopically and microscopically and by cone-beam computed tomography. The TMJ discs were evaluated for their mechanical and biochemical properties...
May 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30173857/comparative-pathogenicity-of-malaysian-qx-like-and-variant-infectious-bronchitis-virus-strains-in-chickens-at-different-age-of-exposure-to-the-viruses
#19
N P Khanh, S W Tan, S K Yeap, H J Lee, K S Choi, M Hair-Bejo, T N Bich, A R Omar
Infectious bronchitis viruses (IBVs) circulating in Malaysia are classified into two groups as Malaysian QX-like and variant strains. In this study, the pathogenicity of IBS130/2015 (QX-like) and IBS037A/2014 (variant) IBVs in 1-day-old and 30-day-old specific pathogen free (SPF) chickens was characterized. Both strains caused respiratory and kidney infections based on immunohistochemistry (IHC), real-time quantitative polymerase chain reaction (qPCR) and a ciliostasis study; however, the results showed that the QX-like strain was more pathogenic, caused higher mortality and showed higher tissue tropism for the kidney than the variant strain...
May 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30173856/flow-cytometric-characterization-of-s-phase-fraction-and-ploidy-in-lymph-node-aspirates-from-dogs-with-lymphoma
#20
B Miniscalco, A Poggi, V Martini, E Morello, M Sulce, M Melega, A Borrelli, A Tarducci, F Riondato
Canine lymphoma is a multifaceted disease encompassing numerous entities with different prognosis. Objective assessment of the proliferation rate is of importance from the pathological and clinical perspectives. Different methods have been described in the literature to assess proliferation rate, including evaluation of Ki67 expression in fresh lymph node (LN) aspirates measured by flow cytometry (FC). This test has a high accuracy in discriminating between low- and high-grade lymphomas, and provides prognostic information among high-grade B-cell lymphomas...
May 2018: Journal of Comparative Pathology
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