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Psychopharmacology Bulletin

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https://www.readbyqxmd.com/read/29713106/risperidone-induced-isolated-thrombocytopenia-a-rare-adverse-event
#1
Dipanjan Bhattacharjee, Devesh Yerrapragada, Bharti Chogtu, Sereen R Thomson
No abstract text is available yet for this article.
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713105/progressive-non-familial-adult-onset-cerebellar-degeneration-an-unusual-occurrence-with-hashimoto-s-thyroiditis
#2
Raghavendra S Rao, Shubha Sheshadri, Dipanjan Bhattacharjee, Navin Patil, Karthik Rao
Progressive non-familial adult onset cerebellar degeneration has been rarely associated with hypothyroidism and is known to be reversible after therapy. We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713104/efficacy-and-tolerability-of-two-different-kinds-of-titration-of-paroxetine-hydrocloride-solution-an-observational-study
#3
REVIEW
Marta Ielmini, Nicola Poloni, Ivano Caselli, Lucia Bianchi, Marcello Diurni, Simone Vender, Camilla Callegari
Background: Depressive disorders are expected to be the second highest cause of morbidity in the world until few years. Moreover, patients with depression frequently show many side effects and low compliance to therapy. To find a more tolerated and more efficacy therapy is a growing need. Objective: This observational study investigates the efficacy, safety and tolerability of paroxetine hydrochloride comparing slow versus standard titration in a population affected by Depressive Disoders (according to DSM 5)...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713103/a-case-of-concomitant-pseudocyesis-and-couvade-syndrome-variant
#4
Srinagesh Mannekote Thippaiah, Vinu George, Badari Birur, Ananda Pandurangi
Per DSM-V, pseudocyesis is included under the category "other specified somatic symptom and related disorder" and is defined as a false belief of being pregnant that is associated with objective signs and reported symptoms of pregnancy. The male counterpart of pseudocyesis is Couvade syndrome, also called "sympathetic pregnancy" where a man experiences symptoms of pregnancy when his female partner is pregnant. There are extensive reports on pseudocyesis and Couvade syndrome in psychiatric literature but none with features of both, in a single case...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713102/major-depressive-disorder-following-dermatomyositis-a-case-linking-depression-with-inflammation
#5
Abhishek Reddy, Badari Birur, Richard C Shelton, Li Li
Major depressive disorder (MDD) is one of the most common psychiatric disorders. Recent studies have shown a strong association between MDD and peripheral inflammation, shown by a higher incidence of depression in patients with inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and systemic lupus erythematosus. Dermatomyositis (DM), an idiopathic inflammatory connective tissue disease that is associated with inflammation, predominantly affects the skin and skeletal muscle...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713101/an-interesting-presentation-about-cyclical-menstrual-psychosis-with-an-updated-review-of-literature
#6
Srinagesh Mannekote Thippaiah, Soumya Nagaraja, Badari Birur, Arnold W Cohen
Cyclical menstrual psychosis is an uncommon, generally a self-limiting mental illness that occurs only in females. It is associated with other menstruation-related disorders and stressful psychogenic factors. Nonetheless, many cases remain unrecognized due to poor awareness of its presence. A young female who presented with psychotic and mood symptoms during each cycle of menstruation was admitted to the psychiatric inpatient unit. There was severe disruption in her activities of daily living and socio-occupational functioning...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713100/do-long-acting-injectable-antipsychotics-prevent-or-delay-hospital-readmission
#7
Thomas J Maestri, Lisa M Mican, Heather Rozea, Jamie C Barner
Introduction: Long-acting injectable (LAI) antipsychotics were developed as a way to decrease pill burden and simplify medication regimens by allowing less frequent administration to assist with medication adherence. Methods: The purpose of this study was to determine whether LAI antipsychotics prevent or delay hospital readmission in patients with a known history of medication non-adherence. The study is a retrospective evaluation of 240 men and women 18-65 years of age diagnosed with bipolar disorder, schizophrenia, or schizoaffective disorder discharged from an inpatient state hospital over a 2 year period of time on a LAI antipsychotic (fluphenazine LAI, haloperidol LAI, risperidone LAI or paliperidone LAI) or oral antipsychotic...
March 13, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713099/dosing-and-monitoring-children-and-adolescents
#8
Glenn S Hirsch
No abstract text is available yet for this article.
February 5, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713098/successful-management-of-psychotropics-induced-stuttering-priapism-with-pseudoephedrine-in-a-patient-with-schizophrenia
#9
Srinagesh Mannekote Thippaiah, Soumya Nagaraja, Badari Birur, Ananda Pandurangi
Stuttering Priapism is a recurrent, persistent penile erection in the absence of sexual desire due to altered genital hemodynamics, affecting the arterial component (high flow, non-ischemic) or the veno-occlusive mechanism (low flow, ischemic). Both typical and atypical antipsychotics increase the risk for priapism with greater implications in typicals than atypicals. Prompt recognition and treatment are important as 40% to 50% of patients with stuttering priapism may develop an erectile dysfunction if left untreated...
February 5, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713097/a-pilot-evaluating-clinical-pharmacy-services-in-an-ambulatory-psychiatry-setting
#10
Valerie A Lindell, Nicole L Stencel, Rachel C Ives, Kristen M Ward, Thomas Fluent, Hae Mi Choe, Jolene R Bostwick
Objectives: A pilot of clinical services provided by psychiatric clinical pharmacists in an outpatient clinic are described and evaluated. The primary objective was to evaluate the difference in change of Patient Health Questionnaire (PHQ)-9 and/or Generalized Anxiety Disorder (GAD) Questionnaire scores between the two groups. Secondary objectives were to assess time patients spent in clinic, time to target psychotropic medication dose, and patient self-reported medication adherence. Experimental Design: Data were collected from January 2014 to November 2015 for patients with depression and/or anxiety who had an appointment within an outpatient psychiatric clinic with either a provider (control) or both a provider and clinical pharmacist (case)...
February 5, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29713096/characterizing-the-effects-of-quetiapine-in-military-post-traumatic-stress-disorder
#11
Gerardo Villarreal, Mark B Hamner, Clifford Qualls, José M Cañive
Objectives: A previous randomized placebo-controlled trial in military veterans posttraumatic stress disorder (PTSD) found that quetiapine improved global PTSD symptoms severity, depression and anxiety as well as the re-experiencing and hypearousal clusters. However, it is not known if individual symptoms had a preferential response to this medication. The goal of this study was to analyze the individual symptom response in this group of patients. Methods: Data from a previous trial was re-analyzed...
February 5, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29382961/erratum
#12
(no author information available yet)
[This corrects the article on p. 29 in vol. 47, PMID: 28936006.][This corrects the article on p. 29 in vol. 47, PMID: 28936006.].
January 15, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29382960/the-black-book-of-psychotropic-dosing-and-monitoring
#13
Alan F Schatzberg, DeBattista Charles
No abstract text is available yet for this article.
January 15, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29382959/the-use-of-complementary-alternative-medicine-in-children-and-adolescents-with-autism-spectrum-disorder
#14
REVIEW
Melissa DeFilippis
Complementary alternative medicine (CAM) is used to a greater degree in children and adolescents with autism spectrum disorder (ASD), when compared to children and adolescents without this diagnosis. There is limited evidence supporting the use of many of these treatments in ASD, despite their popularity. Current FDA approved medications for ASD target associated behavioral symptoms of the diagnosis, not the core symptoms of social communication deficits and restricted/repetitive behaviors. These medications are also associated with concerning adverse effects...
January 15, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29382958/effective-vortioxetine-dose-varies-with-extent-of-antidepressant-use-across-countries
#15
Cuneyt Tegin, Gulay Tegin, Rif S El-Mallakh
Objective: One of the possible explanations for the antidepressant resistance is tolerance to the effect of increasing synaptic serotonin. Vortioxetine is thought to work through a combination of two pharmacological modes of action: serotonin reuptake inhibition and modification of serotonin receptor activity, in a dose-dependent manner. This mechanism of action allows for examination of the hypothesis that antidepressant non-response may be due to exposure to persistently elevated synaptic amine levels...
January 15, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/29382957/major-depression-comorbid-with-medical-conditions-analysis-of-quality-of-life-functioning-and-depressive-symptom-severity
#16
Waguih William IsHak, Alexander J Steiner, Anna Klimowicz, Kaitlyn Kauzor, Jonathan Dang, Brigitte Vanle, Christina Elzahaby, Mark Reid, Lekeisha Sumner, Itai Danovitch
Background: The presence of Major Depressive Disorder (MDD) is often comorbid in patients with a variety of general medical conditions (GMCs) which could lead to less favorable outcomes. Objective: The goal of this analysis is to examine functional outcomes of QOL and functioning before and after antidepressant treatment among patients with MDD with and without GMCs. Methods: We performed a secondary analysis based on the STAR*D database. The analysis included two patient groups from the STAR*D trial: 1,198 patients comorbid with MDD and GMCs (MDD + GMC) and 1,082 patients with MDD and no GMCs (MDDnoGMC), as defined by the Cumulative Illness Rating Scale...
January 15, 2018: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28936011/escitalopram-induced-siadh-in-an-elderly-female-a-case-study
#17
Sudha Vidyasagar, Karthik Rao, Muralidhar Verma, Aswini Dutt Tripuraneni, Navin Patil, Dipanjan Bhattacharjee
Hyponatraemia is a well-established and potentially, a life-threatening adverse effect of selective serotonin receptor uptake inhibitors (SSRI). However, its occurrence secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) with escitalopram, has been reported extremely sporadically. The reporting of such rare, but life-threatening adverse effects of escitalopram assumes immense significance in light of the fact that SSRIs presently form the mainstay of treatment of depressive disorders...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28936010/dextromethorphan-in-cough-syrup-the-poor-man-s-psychosis
#18
Bridgette Martinak, Ramy A Bolis, Jeffrey Ryne Black, Rachel E Fargason, Badari Birur
Dextromethorphan (3-methoxy-N-methylmorphinan), also known as "DXM" and "the poor man's PCP," is a synthetically produced drug that is available in more than 140 over-the-counter cough and cold preparations. Dextromethorphan (DXM) has overtaken codeine as the most widely used cough suppressant due to its availability, efficacy, and safety profile at directed doses. However, DXM is subject to abuse. When consumed at inappropriately high doses (over 1500 mg/day), DXM can induce a state of psychosis characterized by Phencyclidine (PCP)-like psychological symptoms, including delusions, hallucinations, and paranoia...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28936009/collaborative-care-in-ambulatory-psychiatry-content-analysis-of-consultations-to-a-psychiatric-pharmacist
#19
REVIEW
Dorothy Gotlib, Jolene R Bostwick, Seema Calip, Elizabeth Perelstein, Jacob E Kurlander, Thomas Fluent
OBJECTIVES: To determine the volume and nature (or topic) of consultations submitted to a psychiatric pharmacist embedded in an ambulatory psychiatry clinic, within a tertiary care academic medical center and to increase our understanding about the ways in which providers consult with an available psychiatric pharmacist. EXPERIMENTAL DESIGN: Authors analyze and describe the ambulatory psychiatric pharmacist consultation log at an academic ambulatory clinic. All consultation questions were submitted between July 2012 and October 2014...
September 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28936008/physical-activity-diminishes-symptomatic-decline-in-chronic-schizophrenia-a-systematic-review
#20
Sandip P Tarpada, Matthew T Morris
Physical activity has been shown to positively influence a number of parameters in chronic schizophrenia, including cognition, social well being, and quality of life. Here, we present a systematic review of randomized controlled trials reporting on reduction of positive and negative symptoms using PANSS grading after the implementation of a physical activity protocol. Review of 64 articles yielded 6 relevant to our discussion. We found that physical activity significantly improved aggregate total PANSS score as well as positive symptoms PANSS score...
September 15, 2017: Psychopharmacology Bulletin
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