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Pediatric Research

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https://www.readbyqxmd.com/read/30377301/family-reflections-mps-iva
#1
Mary Cavanagh, Scott Cavanagh, Ben Cavanagh
No abstract text is available yet for this article.
October 30, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30374050/oxygen-desaturations-in-the-early-neonatal-period-predict-development-of-bronchopulmonary-dysplasia
#2
Karen D Fairchild, V Peter Nagraj, Brynne A Sullivan, J Randall Moorman, Douglas E Lake
BACKGROUND: Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS: For 502 VLBW infants we quantified bradycardias (HR < 100 for ≥ 4 s) and desaturations (SpO2  < 80% for ≥ 10 s), combined bradycardia and desaturation (BD) events, and percent time in events in the first 4 weeks after birth (32 infant-years of data)...
October 29, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30367163/calling-for-research-articles-on-environmental-health
#3
EDITORIAL
Robert O Wright, Cynthia F Bearer, Nse O Witherspoon
No abstract text is available yet for this article.
October 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30367162/the-aquaporin-4-inhibitor-aer-271-blocks-acute-cerebral-edema-and-improves-early-outcome-in-a-pediatric-model-of-asphyxial-cardiac-arrest
#4
Jessica S Wallisch, Keri Janesko-Feldman, Henry Alexander, Ruchira M Jha, George W Farr, Paul R McGuirk, Anthony E Kline, Travis C Jackson, Marc F Pelletier, Robert S B Clark, Patrick M Kochanek, Mioara D Manole
BACKGROUND: Cerebral edema after cardiac arrest (CA) is associated with increased mortality and unfavorable outcome in children and adults. Aquaporin-4 mediates cerebral water movement and its absence in models of ischemia improves outcome. We investigated early and selective pharmacologic inhibition of aquaporin-4 in a clinically relevant asphyxial CA model in immature rats in a threshold CA insult that produces primarily cytotoxic edema in the absence of blood-brain barrier permeability...
October 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30367161/early-origins-of-neuropsychiatric-disorders
#5
EDITORIAL
Bobbi Fleiss, Scott A Rivkees, Pierre Gressens
No abstract text is available yet for this article.
October 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30367160/adverse-neuropsychiatric-development-following-perinatal-brain-injury-from-a-preclinical-perspective
#6
REVIEW
Ivo Bendix, Martin Hadamitzky, Josephine Herz, Ursula Felderhoff-Müser
Perinatal brain injury is a leading cause of death and disability in young children. Recent advances in obstetrics, reproductive medicine and neonatal intensive care have resulted in significantly higher survival rates of preterm or sick born neonates, at the price of increased prevalence of neurological, behavioural and psychiatric problems in later life. Therefore, the current focus of experimental research shifts from immediate injury processes to the consequences for brain function in later life. The aetiology of perinatal brain injury is multi-factorial involving maternal and also labour-associated factors, including not only placental insufficiency and hypoxia-ischaemia but also exposure to high oxygen concentrations, maternal infection yielding excess inflammation, genetic factors and stress as important players, all of them associated with adverse long-term neurological outcome...
October 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30367159/cortical-interneuron-function-in-autism-spectrum-condition
#7
REVIEW
Jason W Lunden, Madel Durens, Andre W Phillips, Michael W Nestor
Cortical interneurons (INs) are a diverse group of neurons that project locally and shape the function of neural networks throughout the brain. Multiple lines of evidence suggest that a proper balance of glutamate and GABA signaling is essential for both the proper function and development of the brain. Dysregulation of this system may lead to neurodevelopmental disorders, including autism spectrum condition (ASC). We evaluate the development and function of INs in rodent and human models and examine how neurodevelopmental dysfunction may produce core symptoms of ASC...
October 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30367158/soluble-receptor-for-advanced-glycation-end-products-as-a-vasculopathy-biomarker-in-sickle-cell-disease
#8
Nesma Ahmed Safwat, Mahmoud Adel Kenny
BACKGROUND: Soluble forms of RAGE (sRAGE) have been found circulating in plasma and tissues. Evidence is accruing in human subjects linking levels of sRAGE to oxidative stress in many disorders. Because sickle cell disease (SCD) is a state of oxidative stress, we tested the hypothesis that circulating sRAGE levels may be involved in the vascular pathology of SCD. OBJECTIVES: To determine the sRAGE levels in children and adolescents with SCD and investigate their association with markers of hemolysis, iron overload, and SCD-related organ complications...
October 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30356093/early-behavioral-indices-of-inherited-liability-to-autism
#9
REVIEW
John N Constantino
OBJECTIVE: The observed heterogeneity of autism spectrum disorder (ASD)-and the diversity of rare germline mutations with which it has been associated-has been difficult to reconcile with knowledge of its pronounced heritability in the population. METHODS: This article reviews and synthesizes recent family and developmental studies incorporating behavioral indices of inherited risk for ASD. RESULTS: Autism may arise from critical combinations of early inherited neurobehavioral susceptibilities-some specific to autism, some not-each of which may be traceable to partially-independent sets of genetic variation...
October 24, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30397279/erythropoietin-and-neonatal-treatment-still-more-questions-than-answers
#10
Gunnar Naulaers
No abstract text is available yet for this article.
October 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30397278/developmental-influence-of-unconjugated-hyperbilirubinemia-and-neurobehavioral-disorders
#11
REVIEW
Sanjiv B Amin, Tristram Smith, Geralyn Timler
Bilirubin-induced brain injury in the neonatal period has detrimental effects on neurodevelopment that persist into childhood and adulthood, contributing to childhood developmental disorders. Unconjugated bilirubin is a potent antioxidant that may be useful for protecting against oxidative injuries, but it becomes a potent neurotoxin once it crosses the blood brain barrier. Because bilirubin toxicity involves a myriad of pathological mechanisms, can damage most types of brain cells, and affects brain circuits or loops that influence cognition, learning, behavior, sensory, and language, the clinical effects of bilirubin-induced neurotoxicity are likely to be manifold...
October 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30397277/the-time-has-come-to-mitigate-the-risk-of-lead-exposure-from-blood-transfusions
#12
Jennifer Andrews
No abstract text is available yet for this article.
October 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30353042/family-reflections-micropreemies-and-rop
#13
Andrea Mullenmeister
No abstract text is available yet for this article.
October 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30349074/family-reflections-on-hie
#14
Nick Burton
No abstract text is available yet for this article.
October 22, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30349073/commentary-on-the-long-term-effect-of-perinatal-asphyxia-on-hippocampal-volumes
#15
Dalit Cayam-Rand, Steven P Miller
No abstract text is available yet for this article.
October 22, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30397276/ten-years-of-screening-for-congenital-disorders-of-glycosylation-in-argentina-case-studies-and-pitfalls
#16
Carla Gabriela Asteggiano, Magali Papazoglu, María Beatriz Bistué Millón, María Fernanda Peralta, Nydia Beatriz Azar, Norma Spécola Spécola, Norberto Guelbert, Niels Suldrup Suldrup, Marcela Pereyra, Raquel Dodelson de Kremer
BACKGROUND: Congenital Disorders of Glycosylation (CDG) are genetic diseases caused by hypoglycosylation of glycoproteins and glycolipids. Most CDG are multisystem disorders with mild to severe involvement. METHODS: We studied 554 patients (2007-2017) with a clinical phenotype compatible with a CDG. Screening was performed by serum transferrin isoelectric focusing. The diagnosis was confirmed by genetic testing (Sanger or exome sequencing). RESULTS: A confirmed abnormal pattern was found in nine patients...
October 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30385853/impact-of-a-make-a-wish-experience-on-healthcare-utilization
#17
Anup D Patel, Peter Glynn, Ashley M Falke, Megan Reynolds, Richard Hoyt, Allison Hoynes, Melissa Moore-Clingenpeel, Ann Salvator, Jennifer J Moreland
OBJECTIVES: To evaluate the impact of receiving a wish from the Make-A-WishR Foundation on (1) patient healthcare utilization and (2) savings benefit measures. STUDY DESIGN: Make-A-WishR arranges experiences, or "wishes," to children with progressive, life-threatening, or life-limiting illness. A retrospective, case-control analysis was performed comparing patients who received or did not receive a wish and associated impact on healthcare utilization and costs across 2 years...
October 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30353041/effect-of-prebiotic-and-probiotic-supplementation-on-neurodevelopment-in-preterm-very-low-birth-weight-infants-findings-from-a-meta-analysis
#18
REVIEW
Ravi Prakash Upadhyay, Sunita Taneja, Ranadip Chowdhury, Tor A Strand, Nita Bhandari
BACKGROUND: Preterm very low birth weight (VLBW) infants are at risk of gut dysbiosis and neurodevelopmental deficits. Prebiotics and probiotics may modulate gut microbiota and influence brain functions. This review synthesizes literature on effect of prebiotic and/or probiotic supplementation in preterm VLBW on their neurodevelopmental outcomes. METHODS: Search was done using PubMed and CENTRAL. Randomized controlled trials (RCTs) in preterm infants (<37 weeks gestation) and/or infants with birth weight <1500 g that evaluated the effect of prebiotic and/or probiotic supplementation on neurodevelopmental outcomes were included...
October 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30337671/air-pollution-urgent-asthma-medical-visits-and-the-modifying-effect-of-neighborhood-asthma-prevalence
#19
Stephanie Lovinsky-Desir, Luis M Acosta, Andrew G Rundle, Rachel L Miller, Inge F Goldstein, Judith S Jacobson, Steven N Chillrud, Matthew S Perzanowski
BACKGROUND: Social and environmental stressors may modify associations between environmental pollutants and asthma symptoms. We examined if neighborhood asthma prevalence (higher: HAPN vs. lower: LAPN), a surrogate for underlying risk factors for asthma, modified the relationship between pollutants and urgent asthma visits. METHODS: Through zip code, home addresses were linked to New York City Community Air Survey's land use regression model for street-level, annual average nitrogen dioxide (NO2 ), particulate matter (PM2...
October 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30333522/newly-validated-biomarkers-of-brain-damage-may-shed-light-into-the-role-of-oxidative-stress-in-the-pathophysiology-of-neurocognitive-impairment-in-dietary-restricted-phenylketonuria-patients
#20
REVIEW
Dolores Rausell, Ana García-Blanco, Patricia Correcher, Isidro Vitoria, Máximo Vento, Consuelo Cháfer-Pericás
Despite a strict dietary control, patient with hyperphenylalaninemia or phenylketonuria may show cognitive and/or behavioral disorders. These comorbid deficits are of great concern to patients, families, and health organizations. However, biomarkers capable of detecting initial stages of neurological damage are not commonly employed. The pathogenesis of phenylketonuria is complex in nature. Increasingly, the role of oxidative stress has gained acceptance and biomarkers reflecting oxidative damage to the brain and easily accessible in peripheral biofluids have been validated using mass spectrometry techniques...
October 17, 2018: Pediatric Research
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