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Cardiovascular Research

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https://www.readbyqxmd.com/read/27856612/corrigendum
#1
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27856611/loss-of-akap150-promotes-pathological-remodelling-and-heart-failure-propensity-by-disrupting-calcium-cycling-and-contractile-reserve
#2
Lei Li, Jing Li, Benjamin M Drum, Yi Chen, Haifeng Yin, Xiaoyun Guo, Stephen W Luckey, Merle L Gilbert, G Stanley McKnight, John D Scott, L Fernando Santana, Qinghang Liu
AIMS: Impaired Ca(2 + )cycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects of adrenergic regulation of Ca(2+ )cycling and excitation-contraction in cardiomyocytes. However, the role of the AKAP150 signalling complexes in the pathogenesis of heart failure has not been investigated. METHODS AND RESULTS: Here we examined how AKAP150 signalling complexes impact Ca(2+ )cycling, myocyte contractility, and heart failure susceptibility following pathological stress...
November 17, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27856610/corrigendum
#3
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27864310/low-tlr7-gene-expression-in-atherosclerotic-plaques-is-associated-with-major-adverse-cardio-and-cerebrovascular-events
#4
Glykeria Karadimou, Lasse Folkersen, Martin Berg, Ljubica Perisic, Andrea Discacciati, Joy Roy, Göran K Hansson, Jonas Persson, Gabrielle Paulsson-Berne
AIMS: Processes in the development of atherosclerotic lesions can lead to plaque rupture or erosion, which can in turn elicit myocardial infarction or ischaemic stroke. The aims of this study were to determine whether Toll-like receptor 7 (TLR7) gene expression levels influence patient outcome and to explore the mechanisms linked to TLR7 expression in atherosclerosis. METHODS AND RESULTS: Atherosclerotic plaques were removed by carotid endarterectomy (CEA) and subjected to gene array expression analysis (n=123)...
November 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27794519/a-novel-fission-independent-role-of-dynamin-related-protein-1-in-cardiac-mitochondrial-respiration
#5
Huiliang Zhang, Pei Wang, Sara Bisetto, Yisang Yoon, Quan Chen, Shey-Shing Sheu, Wang Wang
AIMS: Mitochondria in adult cardiomyocytes exhibit static morphology and infrequent dynamic changes, despite the high abundance of fission and fusion regulatory proteins in the heart. Previous reports have indicated that fusion proteins may bear functions beyond morphology regulation. Here, we investigated the role of fission protein, dynamin-related protein 1 (DRP1), on mitochondrial respiration regulation in adult cardiomyocytes. METHODS AND RESULTS: By using genetic or pharmacological approaches, we manipulated the activity or protein level of fission and fusion proteins and found they mildly influenced mitochondrial morphology in adult rodent cardiomyocytes, which is in contrast to their significant effect in H9C2 cardiac myoblasts...
October 29, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27742621/tsp1-cd47-signaling-is-upregulated-in-clinical-pulmonary-hypertension-and-contributes-to-pulmonary-arterial-vasculopathy-and-dysfunction
#6
Natasha M Rogers, Maryam Sharifi-Sanjani, Mingyi Yao, Kedar Ghimire, Raquel Bienes-Martinez, Stephanie M Mutchler, Heather E Knupp, Jeffrey Baust, Enrico M Novelli, Mark Ross, Claudette St Croix, Johannes C Kutten, Caitlin A Czajka, John C Sembrat, Mauricio Rojas, David Labrousse-Arias, Timothy N Bachman, Rebecca R Vanderpool, Brian S Zuckerbraun, Hunter C Champion, Ana L Mora, Adam C Straub, Richard A Bilonick, Maria J Calzada, Jeffrey S Isenberg
AIMS: Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1(-/-) mice are protected from pulmonary hypertension (PH). We hypothesized the TSP1-CD47 axis is upregulated in human PH and promotes pulmonary arterial vasculopathy. METHODS AND RESULTS: We analyzed the molecular signature and functional response of lung tissue and distal pulmonary arteries (PAs) from individuals with (n=23) and without (n=16) PH. Compared to controls, lungs and distal PAs from PH patients showed induction of TSP1-CD47 and endothelin-1/endothelin A receptor (ET-1/ETA) protein and mRNA...
October 13, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27702763/glucagon-like-peptide-1-glp-1-mediates-cardioprotection-by-remote-ischaemic-conditioning
#7
Marina V Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L Ackland, Ana Gutierrez Del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V Gourine, Andrey Gourine
AIMS: Although the nature of the humoral factor which mediates cardioprotection established by remote ischaemic conditioning (RIc) remains unknown, parasympathetic (vagal) mechanisms appear to play a critical role. As the production and release of many gut hormones is modulated by the vagus nerve, here we tested the hypothesis that RIc cardioprotection is mediated by the actions of glucagon-like peptide-1 (GLP-1). METHODS AND RESULTS: A rat model of myocardial infarction (coronary artery occlusion followed by reperfusion) was used...
October 4, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27702762/attenuation-of-carotid-neointimal-formation-after-direct-delivery-of-a-recombinant-adenovirus-expressing-glucagon-like-peptide-1-in-diabetic-rats
#8
Soo Lim, Gha Young Lee, Ho Seon Park, Dong-Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Young-Bum Kim, Hee-Sook Jun, Hak Chul Jang, Kyong Soo Park
AIMS: Enhancement of glucagon-like peptide-1 (GLP-1) reduces glucose levels and preserves pancreatic β-cell function, but its effect against restenosis is unknown. METHODS AND RESULTS: We investigated the effect of subcutaneous injection of exenatide or local delivery of a recombinant adenovirus expressing GLP-1 (rAd-GLP-1) into carotid artery, in reducing the occurrence of restenosis following balloon injury. As a control, we inserted β-galactosidase cDNA in the same vector (rAd-βGAL)...
October 4, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27694435/role-of-lipid-phosphate-phosphatase-3-lpp3-in-human-aortic-endothelial-cell-function
#9
Z Touat-Hamici, H Weidmann, Y Blum, C Proust, H Durand, F Iannacci, V Codoni, P Gaignard, P Thérond, M Civelek, A S Karabina, A J Lusis, F Cambien, E Ninio
AIMS: Lipid phosphate phosphatase 3 (LPP3; PPAP2B) is a transmembrane protein dephosphorylating and thereby terminating signalling of lipid substrates including lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). Human LPP3 possesses a cell adhesion motif that allows interaction with integrins. A polymorphism (rs17114036) in PPAP2B is associated with coronary artery disease, which prompted us to investigate the possible role of LPP3 in human endothelial dysfunction, a condition promoting atherosclerosis...
September 30, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27677282/at-the-cross-point-of-connexins-calcium-and-atp-blocking-hemichannels-inhibits-vasoconstriction-of-rat-small-mesenteric-arteries
#10
Mélissa Bol, Nan Wang, Marijke De Bock, Benjamin Wacquier, Elke Decrock, Ashish Gadicherla, Kelly Decaluwé, Bert Vanheel, Harold V van Rijen, Dmitri V Krysko, Geert Bultynck, Geneviève Dupont, Johan Van de Voorde, Luc Leybaert
AIMS: Connexins form gap-junctions (GJs) that directly connect cells, thereby coordinating vascular cell function and controlling vessel diameter and blood flow. GJs are composed of two hemichannels contributed by each of the connecting cells. Hemichannels also exist as non-junctional channels that, when open, lead to the entry/loss of ions and the escape of ATP. Here we investigated cross-talk between hemichannels and Ca(2+)/purinergic signaling in controlling blood vessel contraction...
September 27, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27671804/runx2-deletion-in-smooth-muscle-cells-inhibits-vascular-osteochondrogenesis-and-calcification-but-not-atherosclerotic-lesion-formation
#11
Mu-En Lin, Theodore M Chen, Mary C Wallingford, Ngoc B Nguyen, Shunsuke Yamada, Chenphop Sawangmake, Jaimei Zhang, Mei Y Speer, Cecilia M Giachelli
AIMS: Vascular smooth muscle cells (SMCs) are major precursors contributing to osteochondrogenesis and calcification in atherosclerosis. Runt-related transcription factor-2 (Runx2) has been found essential for SMC differentiation to an osteochondrogenic phenotype and subsequent calcification in vitro A recent study using a conditional targeting allele that produced a truncated Runx2 protein in SMCs of ApoE(-/-) mice showed reduced vascular calcification, likely occurring via reduction of receptor activator of nuclear factor-κB ligand (RANKL), macrophage infiltration, and atherosclerotic lesion formation...
September 26, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27671803/magnetic-resonance-imaging-of-infarct-induced-canonical-wnt-%C3%AE-catenin-tcf-pathway-activation-in-vivo
#12
Marco Matteucci, Valentina Casieri, Khatia Gabisonia, Giovanni Donato Aquaro, Silvia Agostini, Giuseppe Pollio, Daniela Diamanti, Marco Rossi, Massimiliano Travagli, Valentina Porcari, Fabio A Recchia, Vincenzo Lionetti
AIMS: Combined magnetic resonance imaging (MRI) of molecular and morpho-functional changes might prove highly valuable for the elucidation of pathological processes involved in the development of cardiac diseases. Our aim was to test a novel MRI reporter gene for in vivo assessment of the canonical Wnt/β-catenin/TCF pathway activation, an important regulator of post-ischemic cardiac remodeling. METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the β-catenin-responsive TCF/Lef promoter and constitutively expressed green fluorescent protein (GFP)...
September 26, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27671802/endothelial-repair-in-stented-arteries-is-accelerated-by-inhibition-of-rho-associated-protein-kinase
#13
Sarah T Hsiao, Tim Spencer, Luke Boldock, Svenja Dannewitz Prosseda, Ioannis Xanthis, Francesco J Tovar-Lopez, Heleen van Buesekamp, Ramzi Y Khamis, Nicolas Foin, Neil Bowden, Adil Hussain, Alex Rothman, Victoria Ridger, Ian Halliday, Cecile Perrault, Julian Gunn, Paul C Evans
AIMS: Stent deployment causes endothelial cell (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow pertubation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration we identified an intervention that promotes endothelial repair in stented arteries. METHODS AND RESULTS: In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts...
September 26, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27659714/endothelial-cell-derived-pentraxin-3-limits-the-vasoreparative-therapeutic-potential-of-circulating-angiogenic-cells
#14
Christina L O'Neill, Jasenka Guduric-Fuchs, Sarah Ej Chambers, Michelle O'Doherty, Barbara Bottazzi, Alan W Stitt, Reinhold J Medina
AIMS: Circulating Angiogenic Cells (CACs) promote revascularization of ischemic tissues although their underlying mechanism of action and the consequences of delivering varying numbers of these cells for therapy remain unknown. This study investigates molecular mechanisms underpinning CAC modulation of blood vessel formation. METHODS & RESULTS: CACs at low (2x10(5)cells/ml) and mid (2x10(6)cells/ml) cellular densities significantly enhanced endothelial cell (EC) tube formation in vitro, while high density CACs (2x10(7)cells/ml) significantly inhibited this angiogenic process...
September 22, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27635058/systems-biology-opportunities-and-challenges-the-application-of-proteomics-to-study-the-cardiovascular-extracellular-matrix
#15
Javier Barallobre-Barreiro, Marc Lynch, Xiaoke Yin, Manuel Mayr
Systems biology approaches including proteomics are becoming more widely used in cardiovascular research. In this review article, we focus on the application of proteomics to the cardiac extracellular matrix. Extracellular matrix remodelling is a hallmark of many cardiovascular diseases. Proteomic techniques using mass spectrometry provide a platform for the comprehensive analysis of extracellular matrix proteins without a priori assumptions. Proteomics overcomes various constraints inherent to conventional antibody detection...
September 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27635057/mir-153-kv7-4-a-novel-molecular-axis-in-the-regulation-of-hypertension
#16
Angelo Maffei, Vittoria Di Mauro, Daniele Catalucci, Guiseppe Lembo
No abstract text is available yet for this article.
September 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27635056/rules-of-attraction-endothelial-notch-signaling-controls-leukocyte-homing-in-atherosclerosis-via-vcam1
#17
Jaba Gamrekelashvili, Florian P Limbourg
No abstract text is available yet for this article.
September 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27659502/corrigendum
#18
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27659501/conflicting-mechanisms-of-at2-cardioprotection-revealed
#19
EDITORIAL
Raffaele Altara, Sean P Didion, George W Booz
No abstract text is available yet for this article.
October 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/27659500/cardiac-t-tubules-where-structural-plasticity-meets-functional-adaptation
#20
EDITORIAL
Samuel A Watson, Filippo Perbellini, Cesare M Terracciano
No abstract text is available yet for this article.
October 2016: Cardiovascular Research
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