journal
MENU ▼
Read by QxMD icon Read
search

Cardiovascular Research

journal
https://www.readbyqxmd.com/read/28859306/il-10-reprogramming-of-metabolism-in-macrophages-through-mitophagy
#1
Jyoti Patel
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859305/cardiovascular-benefits-and-risks-of-testosterone-replacement-another-warning
#2
Françoise Lenfant, Jean-Francois Arnal
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859304/tilting-at-the-tilted-protease-balance-in-arterial-aneurysmal-disease
#3
Peter Libby, Galina K Sukhova, C Keith Ozaki, Guo-Ping Shi
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859303/context-dependent-signalling-in-platelets-in-vascular-diseases-rock2-around-thrombosis
#4
János G Filep
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859302/future-strategies-for-acute-cardioprotection-melatonin-as-promising-therapy
#5
Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859301/from-drugs-to-devices-and-back-again-chemical-vagal-nerve-stimulation-for-the-treatment-of-heart-failure
#6
Crystal M Ripplinger
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859300/etv2-as-an-essential-regulator-of-mesodermal-lineage-development
#7
Naoko Koyano-Nakagawa, Daniel J Garry
The 'master regulatory factors' that position at the top of the genetic hierarchy of lineage determination have been a focus of intense interest, and have been investigated in various systems. Etv2/Etsrp71/ER71 is such a factor that is both necessary and sufficient for the development of haematopoietic and endothelial lineages. As such, genetic ablation of Etv2 leads to complete loss of blood and vessels, and overexpression can convert non-endothelial cells to the endothelial lineage. Understanding such master regulatory role of a lineage is not only a fundamental quest in developmental biology, but also holds immense possibilities in regenerative medicine...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859299/bioactive-lipids-in-aortic-valve-stenosis-a-possible-link-to-atherosclerosis
#8
Magnus Bäck, Susanna C Larsson
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859298/rock-as-a-molecular-bond-connecting-coronary-microvascular-and-cardiac-remodelling
#9
Daphne Merkus, Johnathan D Tune
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859297/amyloidogenic-medin-induces-endothelial-dysfunction-and-vascular-inflammation-through-the-receptor-for-advanced-glycation-endproducts
#10
Raymond Q Migrino, Hannah A Davies, Seth Truran, Nina Karamanova, Daniel A Franco, Thomas G Beach, Geidy E Serrano, Danh Truong, Mehdi Nikkhah, Jillian Madine
Aims: Medin is a common amyloidogenic protein in humans that accumulates in arteries with advanced age and has been implicated in vascular degeneration. Medin's effect on endothelial function remains unknown. The aims are to assess medin's effects on human arteriole endothelial function and identify potential mechanisms underlying medin-induced vascular injury. Methods and results: Ex vivo human adipose and leptomeningeal arterioles were exposed (1 h) to medin (0...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859296/human-induced-pluripotent-stem-cell-derived-vascular-smooth-muscle-cells-differentiation-and-therapeutic-potential
#11
Sohrab Ayoubi, Søren P Sheikh, Tilde V Eskildsen
Cardiovascular diseases remain the leading cause of death worldwide and current treatment strategies have limited effect of disease progression. It would be desirable to have better models to study developmental and pathological processes and model vascular diseases in laboratory settings. To this end, human induced pluripotent stem cells (hiPSCs) have generated great enthusiasm, and have been a driving force for development of novel strategies in drug discovery and regenerative cell-therapy for the last decade...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859295/melatonin-as-a-cardioprotective-therapy-following-st-segment-elevation-myocardial-infarction-is-it-really-promising-reply
#12
Derek J Hausenloy, David Garcia-Dorado, Hans Erik Bøtker, Sean M Davidson, James Downey, Felix B Engel, Robert Jennings, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Michel Ovize, Cinzia Perrino, Fabrice Prunier, Rainer Schulz, Joost P G Sluijter, Linda W Van Laake, Jakob Vinten-Johansen, Derek M Yellon, Kirsti Ytrehus, Gerd Heusch, Péter Ferdinandy
No abstract text is available yet for this article.
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859294/ccaat-enhancer-binding-protein-delta-promotes-intracellular-lipid-accumulation-in-m1-macrophages-of-vascular-lesions
#13
Hong-Yue Lai, Ling-Wei Hsu, Hsin-Hwa Tsai, Yu-Chih Lo, Shang-Hsun Yang, Ping-Yen Liu, Ju-Ming Wang
Aims: Lipid homeostasis is reprogrammed in the presence of inflammation, which results in excessive lipid accumulation in macrophages, and leads to the formation of lipid-laden foam cells. We aimed to link an inflammation-responsive transcription factor CCAAT/enhancer-binding protein delta (CEBPD) with polarized macrophages and dissect its contribution to lipid accumulation. Methods and results: We found that CEBPD protein colocalized with macrophages in human and mouse (C57BL/6, Apoe-/-) atherosclerotic plaques and that Cebpd deficiency in bone marrow cells suppressed atherosclerotic lesions in hyperlipidemic Apoe-/- mice...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859293/impaired-calcium-homeostasis-is-associated-with-sudden-cardiac-death-and-arrhythmias-in-a-genetic-equivalent-mouse-model-of-the-human-hrc-ser96ala-variant
#14
Christos Tzimas, Daniel M Johnson, Demetrio J Santiago, Elizabeth Vafiadaki, Demetrios A Arvanitis, Constantinos H Davos, Aimilia Varela, Nikolaos C Athanasiadis, Constantinos Dimitriou, Michalis Katsimpoulas, Stephan Sonntag, Mariya Kryzhanovska, Doron Shmerling, Stephan E Lehnart, Karin R Sipido, Evangelia G Kranias, Despina Sanoudou
Aims: The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy. Herein, the role of this variant in cardiac pathophysiology is delineated through a novel mouse model, carrying the human mutation in the homologous mouse position. Methods and results: The mouse HRC serine 81, homologous to human HRC serine 96, was mutated to alanine, using knock-in gene targeting...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28859292/exosomes-secreted-by-cardiomyocytes-subjected-to-ischaemia-promote-cardiac-angiogenesis
#15
Teresa M Ribeiro-Rodrigues, Tiago L Laundos, Rita Pereira-Carvalho, Daniela Batista-Almeida, Ricardo Pereira, Vanessa Coelho-Santos, Ana P Silva, Rosa Fernandes, Monica Zuzarte, Francisco J Enguita, Marina C Costa, Perpetua Pinto-do-Ó, Marta T Pinto, Pedro Gouveia, Lino Ferreira, Justin C Mason, Paulo Pereira, Brenda R Kwak, Diana S Nascimento, Henrique Girão
Aims: Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide and results from an obstruction in the blood supply to a region of the heart. In an attempt to replenish oxygen and nutrients to the deprived area, affected cells release signals to promote the development of new vessels and confer protection against MI. However, the mechanisms underlying the growth of new vessels in an ischaemic scenario remain poorly understood. Here, we show that cardiomyocytes subjected to ischaemia release exosomes that elicit an angiogenic response of endothelial cells (ECs)...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28582477/gingival-fibroblasts-protect-against-experimental-abdominal-aortic-aneurysm-development-and-rupture-through-tissue-inhibitor-of-metalloproteinase-1-production
#16
Andreas Giraud, Lynda Zeboudj, Marie Vandestienne, Jérémie Joffre, Bruno Esposito, Stéphane Potteaux, José Vilar, Daniela Cabuzu, Johannes Kluwe, Sylvie Seguier, Alain Tedgui, Ziad Mallat, Antoine Lafont, Hafid Ait-Oufella
Aims: Abdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix destruction. Despite improvement in the understanding of the pathophysiology of aortic aneurysm, no pharmacological treatment is yet available to limit dilatation and/or rupture. We previously reported that human gingival fibroblasts (GFs) can reduce carotid artery dilatation in a rabbit model of elastase-induced aneurysm...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28575410/enhanced-endothelin-1-rho-kinase-signalling-and-coronary-microvascular-dysfunction-in-hypertensive-myocardial-hypertrophy
#17
Shu-Huai Tsai, Guangrong Lu, Xin Xu, Yi Ren, Travis W Hein, Lih Kuo
Aims: Hypertensive cardiac hypertrophy is associated with reduced coronary flow reserve, but its impact on coronary flow regulation and vasomotor function remains incompletely understood and requires further investigation. Methods and results: Left ventricular hypertrophy was induced in mice by transverse aortic coarctation (TAC) for 4 weeks. The left coronary artery blood velocity (LCABV) and myocardium lactate level were measured following the metabolic activation by isoproterenol...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28472396/chronic-activation-of-hypothalamic-oxytocin-neurons-improves-cardiac-function-during-left-ventricular-hypertrophy-induced-heart-failure
#18
Kara Garrott, Jhansi Dyavanapalli, Edmund Cauley, Mary Kate Dwyer, Sarah Kuzmiak-Glancy, Xin Wang, David Mendelowitz, Matthew W Kay
Aims: A distinctive hallmark of heart failure (HF) is autonomic imbalance, consisting of increased sympathetic activity, and decreased parasympathetic tone. Recent work suggests that activation of hypothalamic oxytocin (OXT) neurons could improve autonomic balance during HF. We hypothesized that a novel method of chronic selective activation of hypothalamic OXT neurons will improve cardiac function and reduce inflammation and fibrosis in a rat model of HF. Methods and results: Two groups of male Sprague-Dawley rats underwent trans-ascending aortic constriction (TAC) to induce left ventricular (LV) hypertrophy that progresses to HF...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28472283/oxldl-derived-lysophosphatidic-acid-promotes-the-progression-of-aortic-valve-stenosis-through-a-lpar1-rhoa-nf-%C3%AE%C2%BAb-pathway
#19
Mohamed Jalloul Nsaibia, Marie-Chloé Boulanger, Rihab Bouchareb, Ghada Mkannez, Khai Le Quang, Fayez Hadji, Deborah Argaud, Abdellaziz Dahou, Yohan Bossé, Marlys L Koschinsky, Philippe Pibarot, Benoit J Arsenault, André Marette, Patrick Mathieu
Aims: Oxidatively modified lipoproteins may promote the development/progression of calcific aortic valve stenosis (CAVS). Oxidative transformation of low-density lipoprotein (OxLDL) generates lysophosphatidic acid (LPA), a lipid mediator that accumulates in mineralized aortic valves. LPA activates at least six different G protein-coupled receptors, which may play a role in the pathophysiology of CAVS. We hypothesized that LPA derived from OxLDL may promote a NF-κB signature that drives osteogenesis in the aortic valve...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28430966/decreased-thromboembolic-stroke-but-not-atherosclerosis-or-vascular-remodelling-in-mice-with-rock2-deficient-platelets
#20
Nikola Sladojevic, Goo Taeg Oh, Hyung-Hwan Kim, Lea M Beaulieu, Hervé Falet, Karol Kaminski, Jane E Freedman, James K Liao
Aims: Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet function, we hypothesized that ROCK2 in platelets will play important role in thrombosis and can be potentially a target for therapeutic intervention in thromboembolic stroke. Methods and results: We generated platelet-specific ROCK2-deficient mice (ROCK2Plt-/-) from conditional ROCK2fl°x/fl°x and platelet factor (PF)-4-Cre transgenic mice...
September 1, 2017: Cardiovascular Research
journal
journal
21592
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"