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Cardiovascular Research

Natasha M Rogers, Maryam Sharifi-Sanjani, Mingyi Yao, Kedar Ghimire, Raquel Bienes-Martinez, Stephanie M Mutchler, Heather E Knupp, Jeffrey Baust, Enrico M Novelli, Mark Ross, Claudette St Croix, Johannes C Kutten, Caitlin A Czajka, John C Sembrat, Mauricio Rojas, David Labrousse-Arias, Timothy N Bachman, Rebecca R Vanderpool, Brian S Zuckerbraun, Hunter C Champion, Ana L Mora, Adam C Straub, Richard A Bilonick, Maria J Calzada, Jeffrey S Isenberg
AIMS: Thrombospondin-1 (TSP1) is a ligand for CD47 and TSP1(-/-) mice are protected from pulmonary hypertension (PH). We hypothesized the TSP1-CD47 axis is upregulated in human PH and promotes pulmonary arterial vasculopathy. METHODS AND RESULTS: We analyzed the molecular signature and functional response of lung tissue and distal pulmonary arteries (PAs) from individuals with (n=23) and without (n=16) PH. Compared to controls, lungs and distal PAs from PH patients showed induction of TSP1-CD47 and endothelin-1/endothelin A receptor (ET-1/ETA) protein and mRNA...
October 13, 2016: Cardiovascular Research
Marina Basalay, Svetlana Mastitskaya, Aleksander Mrochek, Gareth L Ackland, Ana Gutierrez Del Arroyo, Jenifer Sanchez, Per-Ove Sjoquist, John Pernow, Alexander V Gourine, Andrey Gourine
AIMS: Although the nature of the humoral factor which mediates cardioprotection established by remote ischaemic conditioning (RIc) remains unknown, parasympathetic (vagal) mechanisms appear to play a critical role. As the production and release of many gut hormones is modulated by the vagus nerve, here we tested the hypothesis that RIc cardioprotection is mediated by the actions of glucagon-like peptide-1 (GLP-1). METHODS AND RESULTS: A rat model of myocardial infarction (coronary artery occlusion followed by reperfusion) was used...
October 4, 2016: Cardiovascular Research
Soo Lim, Gha Young Lee, Ho Seon Park, Dong-Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Young-Bum Kim, Hee-Sook Jun, Hak Chul Jang, Kyong Soo Park
AIMS: Enhancement of glucagon-like peptide-1 (GLP-1) reduces glucose levels and preserves pancreatic β-cell function, but its effect against restenosis is unknown. METHODS AND RESULTS: We investigated the effect of subcutaneous injection of exenatide or local delivery of a recombinant adenovirus expressing GLP-1 (rAd-GLP-1) into carotid artery, in reducing the occurrence of restenosis following balloon injury. As a control, we inserted β-galactosidase cDNA in the same vector (rAd-βGAL)...
October 4, 2016: Cardiovascular Research
Z Touat-Hamici, H Weidmann, Y Blum, C Proust, H Durand, F Iannacci, V Codoni, P Gaignard, P Thérond, M Civelek, A S Karabina, A J Lusis, F Cambien, E Ninio
AIMS: Lipid phosphate phosphatase 3 (LPP3; PPAP2B) is a transmembrane protein dephosphorylating and thereby terminating signalling of lipid substrates including lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). Human LPP3 possesses a cell adhesion motif that allows interaction with integrins. A polymorphism (rs17114036) in PPAP2B is associated with coronary artery disease, which prompted us to investigate the possible role of LPP3 in human endothelial dysfunction, a condition promoting atherosclerosis...
September 30, 2016: Cardiovascular Research
Mélissa Bol, Nan Wang, Marijke De Bock, Benjamin Wacquier, Elke Decrock, Ashish Gadicherla, Kelly Decaluwé, Bert Vanheel, Harold V van Rijen, Dmitri V Krysko, Geert Bultynck, Geneviève Dupont, Johan Van de Voorde, Luc Leybaert
AIMS: Connexins form gap-junctions (GJs) that directly connect cells, thereby coordinating vascular cell function and controlling vessel diameter and blood flow. GJs are composed of two hemichannels contributed by each of the connecting cells. Hemichannels also exist as non-junctional channels that, when open, lead to the entry/loss of ions and the escape of ATP. Here we investigated cross-talk between hemichannels and Ca(2+)/purinergic signaling in controlling blood vessel contraction...
September 27, 2016: Cardiovascular Research
Mu-En Lin, Theodore M Chen, Mary C Wallingford, Ngoc B Nguyen, Shunsuke Yamada, Chenphop Sawangmake, Jaimei Zhang, Mei Y Speer, Cecilia M Giachelli
AIMS: Vascular smooth muscle cells (SMCs) are major precursors contributing to osteochondrogenesis and calcification in atherosclerosis. Runt-related transcription factor-2 (Runx2) has been found essential for SMC differentiation to an osteochondrogenic phenotype and subsequent calcification in vitro A recent study using a conditional targeting allele that produced a truncated Runx2 protein in SMCs of ApoE(-/-) mice showed reduced vascular calcification, likely occurring via reduction of receptor activator of nuclear factor-κB ligand (RANKL), macrophage infiltration, and atherosclerotic lesion formation...
September 26, 2016: Cardiovascular Research
Marco Matteucci, Valentina Casieri, Khatia Gabisonia, Giovanni Donato Aquaro, Silvia Agostini, Giuseppe Pollio, Daniela Diamanti, Marco Rossi, Massimiliano Travagli, Valentina Porcari, Fabio A Recchia, Vincenzo Lionetti
AIMS: Combined magnetic resonance imaging (MRI) of molecular and morpho-functional changes might prove highly valuable for the elucidation of pathological processes involved in the development of cardiac diseases. Our aim was to test a novel MRI reporter gene for in vivo assessment of the canonical Wnt/β-catenin/TCF pathway activation, an important regulator of post-ischemic cardiac remodeling. METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the β-catenin-responsive TCF/Lef promoter and constitutively expressed green fluorescent protein (GFP)...
September 26, 2016: Cardiovascular Research
Sarah T Hsiao, Tim Spencer, Luke Boldock, Svenja Dannewitz Prosseda, Ioannis Xanthis, Francesco J Tovar-Lopez, Heleen van Buesekamp, Ramzi Y Khamis, Nicolas Foin, Neil Bowden, Adil Hussain, Alex Rothman, Victoria Ridger, Ian Halliday, Cecile Perrault, Julian Gunn, Paul C Evans
AIMS: Stent deployment causes endothelial cell (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow pertubation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration we identified an intervention that promotes endothelial repair in stented arteries. METHODS AND RESULTS: In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts...
September 26, 2016: Cardiovascular Research
Christina L O'Neill, Jasenka Guduric-Fuchs, Sarah Ej Chambers, Michelle O'Doherty, Barbara Bottazzi, Alan W Stitt, Reinhold J Medina
AIMS: Circulating Angiogenic Cells (CACs) promote revascularization of ischemic tissues although their underlying mechanism of action and the consequences of delivering varying numbers of these cells for therapy remain unknown. This study investigates molecular mechanisms underpinning CAC modulation of blood vessel formation. METHODS & RESULTS: CACs at low (2x10(5)cells/ml) and mid (2x10(6)cells/ml) cellular densities significantly enhanced endothelial cell (EC) tube formation in vitro, while high density CACs (2x10(7)cells/ml) significantly inhibited this angiogenic process...
September 22, 2016: Cardiovascular Research
Javier Barallobre-Barreiro, Marc Lynch, Xiaoke Yin, Manuel Mayr
Systems biology approaches including proteomics are becoming more widely used in cardiovascular research. In this review article, we focus on the application of proteomics to the cardiac extracellular matrix. Extracellular matrix remodelling is a hallmark of many cardiovascular diseases. Proteomic techniques using mass spectrometry provide a platform for the comprehensive analysis of extracellular matrix proteins without a priori assumptions. Proteomics overcomes various constraints inherent to conventional antibody detection...
September 15, 2016: Cardiovascular Research
Angelo Maffei, Vittoria Di Mauro, Daniele Catalucci, Guiseppe Lembo
No abstract text is available yet for this article.
September 15, 2016: Cardiovascular Research
Jaba Gamrekelashvili, Florian P Limbourg
No abstract text is available yet for this article.
September 15, 2016: Cardiovascular Research
Yin Peng, Lanying Song, Ding Li, Robert Kesterson, Jianbo Wang, Lizhong Wang, Gregg Rokosh, Bingruo Wu, Qin Wang, Kai Jiao
AIMS: Bone morphogenetic protein (BMP) signalling plays a key role in regulating the development of the atrioventricular (AV) septum and valves; however, the molecules that mediate the complex activities of BMP signalling are not fully understood. The major goal of this study is to identify the critical downstream regulatory targets of BMP signalling in AV cushions, which are precursors of the AV septum and valves. METHODS AND RESULTS: We established a conditional immortal AV cushion mesenchymal cell line, tsA58-AVM...
August 24, 2016: Cardiovascular Research
Zhan-Peng Huang, Yan Ding, Jinghai Chen, Gengze Wu, Masaharu Kataoka, Yongwu Hu, Jian-Hua Yang, Jianming Liu, Stavros G Drakos, Craig H Selzman, Jan Kyselovic, Liang-Hu Qu, Cristobal G Dos Remedios, William T Pu, Da-Zhi Wang
AIMS: Ischemic cardiomyopathy (ICM) resulting from myocardial infarction is a major cause of heart failure (HF). Recently, thousands of long non-coding RNAs (lncRNAs) have been discovered and implicated in a variety of biological processes. However, the role of most lncRNAs in HF remains largely unknown. The aim of this study is to test the hypothesis that the expression and function of lncRNAs are differentially regulated in diseased hearts. METHODS AND RESULTS: In this study, we performed RNA deep sequencing of protein-coding and non-coding RNAs from cardiac samples of patients with ICM (n = 15) and controls (n = 15)...
August 24, 2016: Cardiovascular Research
Meritxell Nus, Beatriz Martínez-Poveda, Donal MacGrogan, Rafael Chevre, Gaetano D'Amato, Mauro Sbroggio, Cristina Rodríguez, José Martínez-González, Vicente Andrés, Andrés Hidalgo, José Luis de la Pompa
AIMS: To determine the role of NOTCH during the arterial injury response and the subsequent chronic arterial-wall inflammation underlying atherosclerosis. METHODS AND RESULTS: We have generated a mouse model of endothelial-specific (Cdh5-driven) depletion of the Notch effector RBPJ (ApoE(-/-);RBPJ(flox/flox);Cdh5-Cre(ERT)). Endothelial-specific deletion of RBPJ or systemic deletion of Notch1 in athero-susceptible ApoE(-/-) mice fed a high cholesterol diet for 6 weeks resulted in reduced atherosclerosis in the aortic arch and sinus...
August 5, 2016: Cardiovascular Research
Jens Buttgereit, Julia Shanks, Dan Li, Guoliang Hao, Arvinder Athwal, Thomas H Langenickel, Hannah Wright, Andrey C da Costa Goncalves, Jan Monti, Ralph Plehm, Elena Popova, Fatimunnisa Qadri, Irina Lapidus, Brent Ryan, Cemil Özcelik, David J Paterson, Michael Bader, Neil Herring
AIMS: B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression in the heart and vasculature. We hypothesized that CNP acts similarly to BNP, and that transgenic rats (TGRs) with neuron-specific overexpression of a dominant negative NPR-B receptor would develop heightened sympathetic drive. METHODS AND RESULTS: Mean arterial pressure and heart rate (HR) were significantly (P < 0...
August 5, 2016: Cardiovascular Research
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Cardiovascular Research
Raffaele Altara, Sean P Didion, George W Booz
No abstract text is available yet for this article.
October 2016: Cardiovascular Research
Samuel A Watson, Filippo Perbellini, Cesare M Terracciano
No abstract text is available yet for this article.
October 2016: Cardiovascular Research
Aurelia De Pauw, Paul Massion, Belaid Sekkali, Emilie Andre, Caroline Dubroca, Jana Kmecova, Caroline Bouzin, Ann Friart, Catherine Sibille, Patrick Gilon, Delphine De Mulder, Hrag Esfahani, Adrien Strapart, Ruben Martherus, Valéry Payen, Pierre Sonveaux, Peter Brouckaert, Stefan Janssens, Jean-Luc Balligand
AIM: Cardiac progenitor cells (CPC) from adult hearts can differentiate to several cell types composing the myocardium but the underlying molecular pathways are poorly characterized. We examined the role of paracrine nitric oxide (NO) in the specification of CPC to the cardiac lineage, particularly through its inhibition of the canonical Wnt/β-catenin pathway, a critical step preceding cardiac differentiation. METHODS AND RESULTS: Sca1 + CPC from adult mouse hearts were isolated by magnetic-activated cell sorting and clonally expanded...
October 2016: Cardiovascular Research
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