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Planta Medica

Maria Elisa M B de Araújo, Yollanda E M Franco, Marcia C F Messias, Giovanna B Longato, João A Pamphile, Patricia de O Carvalho
Several studies have described important biological activities of flavonoids such as coronary heart disease prevention, hepatoprotective, anti-inflammatory and anticancer activities, enzyme inhibition activity, and antibacterial, antifungal, and antiviral activities. Flavonoids show promising activity as natural plant-based antioxidants due to their antioxidant and free radical scavenging properties. However, their primary applications as antioxidants in the pharmaceutical, cosmetic, and food industries are limited because of their moderately hydrophilic nature...
December 5, 2016: Planta Medica
Abderrahman El Bouakher, Badr Jismy, Hassan Allouchi, Eric Duverger, Latifa Barkaoui, Ahmed El Hakmaoui, Richard Daniellou, Gérald Guillaumet, Mohamed Akssira
Motivated by the widely reported anticancer activity of parthenolides and their derivatives, a series of new substituted parthenolides was efficiently synthesized. Structural modifications were performed at the C-9 and C-13 positions of 9α- and 9β-hydroxyparthenolide, which were isolated from the aerial parts of Anvillea radiata. Twenty-one derivatives were synthesized and evaluated for their in vitro cytotoxic activity against HS-683, SK-MEL-28, A549, and MCF-7 human cancer cell lines using the MTT colorimetric assay...
December 5, 2016: Planta Medica
Ying Mu, Zhaohui Xu, Xuanxuan Zhou, Huinan Zhang, Qian Yang, Yunlong Zhang, Yanhua Xie, Juan Kang, Feng Li, Siwang Wang
Cerebral ischemia can cause brain infarcts, which are difficult to recover due to poor angiogenesis. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside is a natural polyphenol, has antioxidant and anti-inflammatory activity, and can protect from ischemic neuronal injury. However, little is known about the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside on brain microcirculation after stroke. This study aimed at investigating the influence of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside on brain lesions and angiogenesis after stroke...
November 28, 2016: Planta Medica
Behzad Zolfaghari, Zeinab Yazdiniapour, Masoud Sadeghi, Raffaele Troiano, Virginia Lanzotti
An extensive phytochemical analysis of the polar extracts from bulbs of Welsh onion Allium fistulosum L. led to the isolation of nine saponins, four of them, named fistulosaponins G (1a/1b), H (2), I (3a/3b), and J (4), have never been reported previously. Fistulosaponins G and I were isolated as a couple of isomers in equilibrium. On the basis of 2D NMR and mass spectrometry data, the structure of the novel compounds were elucidated as (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (1a) with its 22α epimer (1b), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (2), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (3a) with its 22α epimer (3b), and (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (4)...
November 16, 2016: Planta Medica
Miao Dong, Dan Liu, Yan-Hong Li, Xuan-Qin Chen, Kai Luo, Yong-Ming Zhang, Rong-Tao Li
Four new naphthoquinones (1-4), including a dimeric one, shikometabolin G (1), together with six known ones (6-10), were isolated from the methanol extract of Onosma paniculatum. Their structures were established based on the analysis of NMR and MS spectroscopic data. All of the compounds were evaluated for inhibitory effects on NO production in murine macrophage RAW 264.7 cells. Compounds 2, 3, 5, 6, 7, 8, and 10 displayed good activity on the inhibition of NO production (IC50 = 0.4-16.5 µM), suggesting the potential property of anti-inflammation...
November 16, 2016: Planta Medica
Milena Masullo, Cosimo Pizza, Sonia Piacente
The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcher's broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp...
November 8, 2016: Planta Medica
Kuo-Jun Zhang, Qin-Lan Gu, Kan Yang, Xian-Jun Ming, Jin-Xin Wang
Cancer chemoprevention is a promising strategy taken to block, reverse, or retard carcinogenesis. α-Mangostin, a natural xanthone isolated from the pericarps of mangosteen, represents one of the most studied chemopreventive agents. This compound has been reported to interfere with all the major stages of carcinogenesis: initiation, promotion, and progression. A number of mechanisms have been proposed for its anticarcinogenic activities. This review summarizes the current knowledge on the mechanisms that contribute to the observed activity of α-mangostin related to (i) modulation of carcinogenic biotransformation and mitigation of oxidative damage, (ii) induction of growth arrest and apoptosis, (iii) suppression of angiogenesis and metastasis, and (iv) combination with clinical chemotherapy drugs enhancing their efficacy and decreasing the toxic side effects...
November 4, 2016: Planta Medica
Ana Laura Martínez, Abraham Madariaga-Mazón, Isabel Rivero-Cruz, Robert Bye, Rachel Mata
The purpose of this research was to examine the preclinical efficacy of a decoction from the roots of Acourtia thurberi as a hypoglycemic, antihyperglycemic, and antihyperalgesic agent using well-known experimental models in mice. Acute oral administration of A. thurberi decoction did not produce toxic effects in mice, according to the Lorke procedure. A. thurberi decoction (31.6-316.2 mg/kg, p. o.) decreased blood glucose levels during acute hypoglycemic and the oral glucose tolerance and oral sucrose tolerance tests, both in normoglycemic and hyperglycemic animals...
November 4, 2016: Planta Medica
Valentina Sinisi, Annelies Stevaert, Federico Berti, Cristina Forzato, Fabio Benedetti, Luciano Navarini, Anita Camps, Leentje Persoons, Kurt Vermeire
Chlorogenic acids are secondary metabolites in diverse plants. Some chlorogenic acids extracted from traditional medicinal plants are known for their healing properties, e.g., against viral infections. Also, green coffee beans are a rich source of chlorogenic acids, with 5-O-caffeoylquinic acid being the most abundant chlorogenic acid in coffee. We previously reported the synthesis of the regioisomers of lactones, bearing different substituents on the quinidic core. Here, 3,4-O-dicaffeoyl-1,5-γ-quinide and three dimethoxycinnamoyl-γ-quinides were investigated for in vitro antiviral activities against a panel of 14 human viruses...
November 2, 2016: Planta Medica
Wei Li, Ya-Bin Yang, Xue-Qiong Yang, Hui-Ding Xie, Zhi-Hui Shao, Hao Zhou, Cui-Ping Miao, Li-Xing Zhao, Zhong-Tao Ding
The rare anishidiol and five new isochromans, including three novel dimers with unprecedented skeletons, were isolated from Stachybotrys sp. PH30583. Their structures were determined by spectral analyses. The bioactivities of these compounds were also investigated. The dimers (6-10) inhibited acetylcholinesterase at 50 µM, but the monomers did not. To investigate the biogenesis of the novel dimers, a time-course investigation of metabolite production was undertaken.
November 2, 2016: Planta Medica
Su-Hyeon Eun, Je-Te Woo, Dong-Hyun Kim
In the preliminary study, tangeretin (5,6,7,8,4'-pentamethoxy flavone), a major constituent of the pericarp of Citrus sp., inhibited TNF-α, IL-12, and IL-23 expression and nuclear factor kappa-B activation in lipopolysaccharide-stimulated dendritic cells; however, it did not affect IL-10 expression. Furthermore, tangeretin (5, 10, and 20 µM) suppressed the activation and translocation of nuclear factor kappa-B (p65) into the nuclei in vitro by inhibiting the binding of lipopolysaccharide on dendritic cells...
November 2, 2016: Planta Medica
Gibson Gomes de Oliveira, Fausto Carnevale Neto, Daniel Pecoraro Demarque, José Antônio de Sousa Pereira-Junior, Rômulo César Sampaio Peixoto Filho, Sebastião José de Melo, Jackson Roberto Guedes da Silva Almeida, João Luiz Callegari Lopes, Norberto Peporine Lopes
The interpretation of large datasets acquired using high performance liquid chromatography coupled with tandem mass spectrometry represents one of the major challenges in natural products research. Here we propose the use of molecular networking to rapid identify the known secondary metabolites from untargeted MS/MS analysis of Adenocalymma imperatoris-maximilianii plant extracts. The leaves, stems and roots of A. imperatoris-maximilianii were extracted using different solvents according to Snyder selectivity triangle...
November 2, 2016: Planta Medica
Ines van Dooren, Kenn Foubert, Sebastiaan Bijttebier, Mart Theunis, Stefaniya Velichkova, Magda Claeys, Luc Pieters, Vassiliki Exarchou, Sandra Apers
Stone diseases present a major health problem in the Western society, since both urinary and biliary stones occur with a relatively high prevalence of 10-12 % and 10-20 %, respectively, and demonstrate a high recurrence rate. At the moment treatment is mainly based on interventional procedures, or prophylactic and dissolution therapy. However, many of the current drugs cause severe side effects, and therefore, there is an increasing interest in natural medicines. At the moment no registered herbal medicinal products are available for treatment of gallstones...
October 24, 2016: Planta Medica
Joël Doussot, Véronique Mathieu, Cyril Colas, Roland Molinié, Cyrielle Corbin, Josiane Montguillon, Laeticia Moreno Y Banuls, Sullivan Renouard, Frédéric Lamblin, Patricia Dupré, Benoit Maunit, Robert Kiss, Christophe Hano, Eric Lainé
Podophyllotoxin, a lignan still extracted from the rhizomes of Podophyllum hexandrum (Berberidaceae), is the starting molecule for the semisynthesis of widely used anticancer drugs such as etoposide. However, this source is threatened by the over-collection of P. hexandrum. Plants belonging to the Linaceae and Cupressaceae families could be attractive alternative sources with species that contain the lignan podophyllotoxin or its precursors and derivatives. Wild flax species, such as Linum flavum, as well as some Juniperus and Callitris species were investigated for their lignan content, and the in vitro antiproliferative capacity of their extracts was assayed on four tumor cell lines...
October 24, 2016: Planta Medica
Simon Bordage, Thanh-Nhat Pham, Andy Zedet, Anne-Sophie Gugglielmetti, Maude Nappey, Céline Demougeot, Corine Girard-Thernier
Polyphenols are plant secondary metabolites which possess many positive effects on human health. Although these beneficial effects could be mediated through an increase in nitric oxide synthase activity, little is known regarding the inhibitory effect of polyphenols on mammal arginase, an enzyme which competes with nitric oxide synthase for their common substrate, L-arginine. The aim of the present study was to determine the potential of a series of polyphenols as mammalian arginase inhibitors and to identify some structure-activity relationships...
October 24, 2016: Planta Medica
Carolin de Groot, Christel C Müller-Goymann
Saponins are used in medicine due to their pharmacological and immunological effects. To better understand interactions of saponins with model membranes and natural membranes of, for example, erythrocytes, Langmuir film balance experiments are well established. For most saponins, a strong interaction with cholesterol was demonstrated in dependence of both the aglycone part and the sugar moieties and is suggested to be correlated with a strong hemolytic activity, high toxicity, and high surface activity, as was demonstrated for the steroid saponin digitonin...
October 19, 2016: Planta Medica
Nurkhalida Kamal, Christina V Viegelmann, Carol J Clements, RuAngelie Edrada-Ebel
Fungal endophytes offer diverse and unique secondary metabolites, making these organisms potential sources of promising drug leads. The application of high-resolution-liquid chromatography mass spectrometry and nuclear magnetic resonance-based metabolomics to fungal endophytes is practical in terms of dereplication studies and the mining of bioactive compounds. In this paper, we report the application of metabolomics in parallel with anti-trypanosomal assays to determine the ideal conditions for the medium-scale fermentation of the endophyte Lasiodiplodia theobromae...
October 19, 2016: Planta Medica
Mirka Laavola, Tiina Leppänen, Heikki Eräsalo, Mari Hämäläinen, Riina Nieminen, Eeva Moilanen
Nortrachelogenin is a pharmacologically active lignan found in knot extracts of Pinus sylvestris. In previous studies, some lignans have been shown to have anti-inflammatory properties, which made nortrachelogenin an interesting candidate for our study. In inflammation, bacterial products and cytokines induce the expression of inducible nitric oxide synthase, cyclooxygenase-2, and microsomal prostaglandin E synthase-1. These enzymes synthesize factors, which, together with proinflammatory cytokines, are important mediators and drug targets in inflammatory diseases...
October 13, 2016: Planta Medica
Paulina Koczurkiewicz, Ewa Kowolik, Irma Podolak, Dawid Wnuk, Kamil Piska, Anna Łabędź-Masłowska, Katarzyna Wójcik-Pszczoła, Elżbieta Pękala, Jarosław Czyż, Marta Michalik
Triterpene saponins are secondary metabolites typical for higher plants. They possess a wide range of pharmaceutical and biological activities. These include anti-inflammatory, vasoprotective, expectorant, and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs has opened new perspectives for their application in combined cancer chemotherapy. In this study, the biological activity of the saponin fraction isolated from Lysimachia ciliata (denoted as CIL-1/2) was evaluated to assess its chemosensitizing activity in prostate cancer cell lines (DU-145, PC-3)...
October 13, 2016: Planta Medica
Kenn Foubert, Taposh Gorella, Ahmad Faizal, Paul Cos, Louis Maes, Sandra Apers, Danny Geelen, Luc Pieters
Within an ongoing research program on saponins with potential antileishmanial activity, four previously undescribed saponins were isolated from Maesa argentea leaves and identified by LC-MS/MS, GC-MS, and 1D and 2D NMR spectroscopy as 3β-O-{([β-D-glucopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β-angeloyloxy-22α-butanoyloxy-13β,28-oxidoolean-16α,28α-diol (1), 3β-O-{([β-D-glucopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β,22α-angeloyloxy-13β,28-oxidoolean-16α,28α-diol (2), 3β-O-{([β-D-glucopyranosyl-(1 → 2)-α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β-angeloyloxy-22α-(E)-cinnamoyloxy-13β,28-oxidoolean-16α,28α-diol (3), and 3β-O-{([α-L-rhamnopyranosyl-(1 → 2)-β-D-galactopyranosyl-(1 → 3)]-[β-D-galactopyranosyl-(1 → 2)]-β-D-glucuronopyranosyl)}-21β-angeloyloxy-22α-(E)-cinnamoyloxy-13β,28-oxidoolean-16α,28α-diol (4)...
October 13, 2016: Planta Medica
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