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Planta Medica

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https://www.readbyqxmd.com/read/30016828/traditional-uses-phytochemistry-and-antimicrobial-activities-of-eugenia-species-a-review
#1
Angela Maria de Souza, Camila Freitas de Oliveira, Vinícius Bednarczuk de Oliveira, Fernando Cesar Martins Betim, Obdulio Gomes Miguel, Marilis Dallarmi Miguel
Antimicrobial resistance is a critical health problem, and pathogens responsible for common infections have developed resistance to antimicrobials, posing a threat to global health and placing a huge burden on health services. During the past two decades, the search for new bioactive agents in nature has become extremely important for promoting health and in the development of more efficient antimicrobials. The genus Eugenia is one of the largest in the Myrtaceae family, comprising approximately 1000 species from Mexico to Argentina, with a few species distributed in Australia and Africa...
July 17, 2018: Planta Medica
https://www.readbyqxmd.com/read/30016827/delitpyrones-%C3%AE-pyrone-derivatives-from-a-freshwater-delitschia-sp
#2
José Rivera-Chávez, Tamam El-Elimat, Jacklyn M Gallagher, Tyler N Graf, Jacques Fournier, Gati K Panigrahi, Gagan Deep, Rick L Bunch, Huzefa A Raja, Nicholas H Oberlies
In research focused on the discovery of new chemical diversity from freshwater fungi, a peak library was built and evaluated against a prostate cancer cell line, E006AA-hT, which was derived from an African American, as this population is disproportionately affected by prostate cancer. The chemical study of the bioactive sample accessioned as G858 ( Delitschia sp.) led to the isolation of eight new α -pyrone derivatives (1:  - 7: , and 11: ), as well as the new 3 S* ,4 S* -7-ethyl-4,8-dihydroxy-3,6-dimethoxy-3,4-dihydronaphthalen-1( 2H )-one (15: )...
July 17, 2018: Planta Medica
https://www.readbyqxmd.com/read/30016826/differential-modulation-of-gene-expression-encoding-hepatic-and-renal-xenobiotic-metabolizing-enzymes-by-an-aspalathin-enriched-rooibos-extract-and-aspalathin
#3
Sameega Abrahams, Sedicka Samodien, Mariska Lilly, Elizabeth Joubert, Wentzel Gelderblom
Modulation of the expression of hepatic and renal genes encoding xenobiotic metabolizing enzymes by an aspalathin-enriched green rooibos ( Aspalathus linearis ) extract (GRE) was investigated in the liver and kidneys of F344 rats following dietary exposure of 28 d, as well as selected xenobiotic metabolizing genes in rat primary hepatocytes. In the liver, GRE upregulated genes (p < 0.05) encoding aldehyde dehydrogenase, glucose phosphate isomerase, and cytochrome P450 while 17 β -hydroxysteroid dehydrogenase 2 ( Hsd17 β 2 ) was downregulated...
July 17, 2018: Planta Medica
https://www.readbyqxmd.com/read/30005428/rapid-and-simultaneous-determination-of-three-active-components-in-raw-and-processed-root-samples-of-scutellaria-baicalensis-by-near-infrared-spectroscopy
#4
Xue Jintao, Yang Quanwei, Li Chunyan, Jing Yun, Wang Shuangxi, Zhang Mingxiang, Li Peng
Motivated by the wide use of Scutellariae Radix (SR) in the food and pharmaceutical industries, a rapid and non-destructive near-infrared spectroscopy (NIRS) method was developed for the simultaneous analysis of three main active components in raw SR and SR processed by stir-frying with wine. From seven geographical areas, 58 samples were collected. The reference contents for the SR components baicalin, baicalein, and wogonin were determined by high-performance liquid chromatography. Two multivariate analysis methods, partial least-squares (PLS) regression as a linear regression method and artificial neural networks (ANN) as a nonlinear regression method, were applied to the NIR data, and their results were compared...
July 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/29996165/triterpenoids-from-momordica-balsamina-with-a-collateral-sensitivity-effect-for-tackling-multidrug-resistance-in-cancer-cells
#5
Cátia Ramalhete, Silva Mulhovo, Hermann Lage, Maria-José U Ferreira
The collateral sensitivity effect is among the most promising strategies for overcoming multidrug resistance in cancer. In this work, 28 cucurbitane-type triterpenoids (1: -28: ), previously isolated from the African medicinal plant Momordica balsamina and its derivatives, were evaluated for their collateral sensitivity effect on three different human cancer entities, gastric (EPG85-257), pancreatic (EPP85-181), and colon (HT-29), each with two different multidrug-resistant variants. One was selected for its resistance to daunorubicin (EPG85-257RDB, EPP85-181RDB, HT-29RDB) and the other was selected for its resistance to mitoxantrone (EPG85-257RNOV, EPP85-181RNOV, HT-29RNOV)...
July 11, 2018: Planta Medica
https://www.readbyqxmd.com/read/29991081/antimicrobial-dialkylresorcins-from-marine-derived-microorganisms-insights-into-their-mode-of-action-and-putative-ecological-relevance
#6
Henrik Harms, Anna Klöckner, Jan Schrör, Michaele Josten, Stefan Kehraus, Max Crüsemann, Wiebke Hanke, Tanja Schneider, Till F Schäberle, Gabriele M König
Zobellia galactanivorans has been reported as a seaweed-associated or marine-derived species with largely unknown secondary metabolites. The combination of bioinformatic analysis and MS- and bioactivity guided separation led to the isolation of a new antibiotically active dialkylresorcin from the marine bacterium Z. galactanivorans . The antibiotic profile of the new dialkylresorcin zobelliphol ( 1: ) was investigated and compared with related and naturally occurring dialkyresorcins (i.e., stemphol ( 2: ) and 4-butyl-3,5-dihydroxybenzoic acid ( 3: )) from the marine-derived fungus Stemphylium globuliferum ...
July 10, 2018: Planta Medica
https://www.readbyqxmd.com/read/29986352/new-hirsutinolide-type-sesquiterpenoids-from-vernonia-cinerea-inhibit-nitric-oxide-production-in-lps-stimulated-raw264-7-cells
#7
Li-Ming Yang Kuo, Pei-Yi Tseng, Yu-Chi Lin, Chia-Ching Liaw, Li-Jie Zhang, Keng-Chang Tsai, Zhi-Hu Lin, Hsiu-O Ho, Yao-Haur Kuo
Phytochemical investigation of ethanol extracts from two Taiwanese collections of Vernonia cinerea resulted in the isolation of eighteen hirsutinolide-type sesquiterpenoids, including seven new ones designated as vernolides E - K (1: -7: ). All structures were determined by a combination of detailed spectroscopic analyses (NMR and MS) and comparison with reported data. In an in vitro anti-inflammatory assay, compounds 3, 7, 9, 11: , and 14: exhibited strong inhibitory activities toward NO production by LPS-induced RAW264...
July 9, 2018: Planta Medica
https://www.readbyqxmd.com/read/29954027/fusarihexins-a-and-b-novel-cyclic-hexadepsipeptides-from-the-mangrove-endophytic-fungus-fusarium-sp-r5-with-antifungal-activities
#8
Xinwei Zhu, Yu Zhong, Zihui Xie, Manlin Wu, Zhibo Hu, Weijia Ding, Chunyuan Li
Two novel cyclic hexadepsipeptides, fusarihexin A (1: ) and fusarihexin B (2: ), and two known compounds, cyclo-(L-Leu-L-Leu-D-Leu-L-Leu-L-Val) (3: ) and cyclo-(L-Leu-L-Leu-D-Leu-L-Leu-L-Ile) (4: ), were isolated from the marine mangrove endophytic fungus Fusarium sp. R5. Their chemical structures were elucidated on the basis of spectroscopic data and Marfey's analysis. In an in vitro bioassay, fusarihexin A (1: ) remarkably inhibited three plant pathogenic fungi: Colletotrichum gloeosporioides (Penz.) Sacc...
June 28, 2018: Planta Medica
https://www.readbyqxmd.com/read/29954026/four-new-2-2-phenylethyl-4h-chromen-4-one-derivatives-from-the-resinous-wood-of-aquilaria-sinensis-and-their-inhibitory-activities-on-neutrophil-pro-inflammatory-responses
#9
Sin-Ling Wang, Hsiang-Ruei Liao, Ming-Jen Cheng, Chih-Wen Shu, Chun-Lin Chen, Mei-Ing Chung, Jih-Jung Chen
Four new 2-(2-phenylethyl)-4 H -chromen-4-one derivatives, 6-hydroxy-5-methoxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (1: ), 6,7-dimethoxy-2-[2-(2'-hydroxyphenyl)ethyl]chromone (2: ), 5-hydroxy-6-methoxy-2-[2-(3'-methoxyphenyl)ethyl]-chromone (3: ), and 7-chloro-8-hydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (4: ), have been isolated from the resinous wood of Aquilaria sinensis , together with 16 known compounds (5: -20: ). Among these, 7-methoxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (5: ) was isolated from a natural source for the first time...
June 28, 2018: Planta Medica
https://www.readbyqxmd.com/read/29940661/anti-inflammatory-ingenane-diterpenoids-from-the-roots-of-euphorbia-kansui
#10
Jun-Sheng Zhang, Han-Zhuang Weng, Jia-Luo Huang, Gui-Hua Tang, Sheng Yin
Bioassay-guided fractionation of the ethanolic extract of the roots of Euphorbia kansui led to the isolation of two new ingenane diterpenoids, euphorkans A (1: ) and B (2: ), together with 16 known analogues (3:  - 18: ). Their structures were determined by combined spectral and chemical methods. All the isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells. Compounds 1:  - 6: and 10:  - 13: exhibited pronounced inhibitory activity with IC50 values in the range of 2...
June 25, 2018: Planta Medica
https://www.readbyqxmd.com/read/29940660/single-lab-validation-for-determination-of-kavalactones-and-flavokavains-in-piper-methysticum-kava
#11
Ying Liu, Jensen A Lund, Susan J Murch, Paula N Brown
Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance for the Pacific Islanders. Kava is also sold as a herbal supplement or recreational beverage consumed for its mild inebriating effect in Europe and North America. With an ongoing interest in the safety and quality of kava products, it is necessary to develop a validated method for determination of kava chemical composition to ensure confidence in quality assessment...
June 25, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929208/dna-barcoding-for-the-identification-of-phyllanthus-taxa-used-medicinally-in-brazil
#12
Peter W Inglis, Lorena R Mata, Marcos José da Silva, Roberto F Vieira, Rosa de B N Alves, Dijalma B Silva, Vânia C R Azevedo
Plants of the genus Phyllanthus, principally Phyllanthus amarus, Phyllanthus urinaria, Phyllanthus niruri , and Phyllanthus tenellus, are used in Brazilian folk medicine to treat kidney stones as well as other ailments, where the latter two species are listed in the Brazilian Pharmacopeia as quebra-pedra ( stone-breaker ). However, only P. niruri has been shown to be effective in a clinical setting. Nuclear ribosomal internal transcribed spacer (ITS1 - 5.8S rRNA-ITS2), internal transcribed spacer 2, and chloroplasts rbc L, mat K, psb A- trn H, trn L, and trn L- trn F were screened for their potential as DNA barcodes for the identification of 48 Phyllanthus taxa in Brazilian medicinal plant germplasm banks and in "living pharmacies"...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929207/heart-protective-effects-of-echinodorus-grandiflorus-in-rabbits-that-are-fed-a-high-cholesterol-diet
#13
Francielly Mourão Gasparotto, Francislaine Aparecida Dos Reis Lívero, Rhanany Allan Caloi Palozi, Maria Leticia Ames, Bruna Nunes, Guilherme Donadel, Rita de Cassia Lima Ribeiro, Emerson Luiz Botelho Lourenço, Cândida Aparecida Leite Kassuya, Arquimedes Gasparotto Junior
Excess weight and dyslipidemia are among the most serious health problems in Western societies. These conditions enhance the risk of cardiac disease and have been linked with a higher prevalence of cardiac arrhythmias and sudden death. The present study investigated the cardioprotective effects of Echinodorus grandiflorus on ventricular remodeling in rabbits that were fed a 1% cholesterol-rich diet. We first obtained an ethanol-soluble fraction of E. grandiflorus and performed a detailed phytochemical study by liquid chromatography-DAD/ESI-MS...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929206/an-integrated-strategy-to-qualitatively-differentiate-components-of-raw-and-processed-viticis-fructus-based-on-nir-hplc-and-uplc-ms-analysis
#14
Jiayin Diao, Can Xu, Huiting Zheng, Siyi He, Shumei Wang
Viticis Fructus is a traditional Chinese herbal drug processed by various methods to achieve different clinical purposes. Thermal treatment potentially alters chemical composition, which may impact on effectiveness and toxicity. In order to interpret the constituent discrepancies of raw versus processed (stir-fried) Viticis Fructus, a multivariate detection method (NIR, HPLC, and UPLC-MS) based on metabonomics and chemometrics was developed. Firstly, synergy interval partial least squares and partial least squares-discriminant analysis were employed to screen the distinctive wavebands (4319 - 5459 cm-1 ) based on preprocessed near-infrared spectra...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29929205/in-vivo-antimalarial-and-antitrypanosomal-activity-of-strychnogucine-b-a-bisindole-alkaloid-from-strychnos-icaja
#15
Claire Beaufay, Allison Ledoux, Olivia Jansen, Annélise Bordignon, Senzhi Zhao, Christiana N Teijaro, Rodrigo B Andrade, Joëlle Quetin-Leclercq, Michel Frédérich
Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties. This compound was synthesized in four steps from (-)-strychnine. As no acute toxicity was observed at the highest tested cumulative dose of 60 mg/kg, its in vivo antimalarial activity was determined intraperitoneally at 30 mg/kg/d in a Plasmodium berghei murine model. In the Peters's 4-d suppressive test, this alkaloid suppressed the parasitaemia by almost 36% on day 5 and 60% on day 7 compared to vehicle-treated mice...
June 21, 2018: Planta Medica
https://www.readbyqxmd.com/read/29925102/safety-and-toxicology-of-magnolol-and-honokiol
#16
Andrea Sarrica, Natalja Kirika, Margherita Romeo, Mario Salmona, Luisa Diomede
Magnolia officinalis and Magnolia obovata bark extracts have been used for thousands of years in Chinese and Japanese traditional medicines and are still widely employed as herbal preparations for their sedative, antioxidant, anti-inflammatory, antibiotic, and antispastic effects. Neolignans, particularly magnolol and honokiol, are the main substances responsible for the beneficial properties of the magnolia bark extract (MBE). The content of magnolol and honokiol in MBE depends on different factors, including the Magnolia plant species, the area of origin, the part of the plant employed, and the method used to prepare the extract...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29925101/the-difference-between-white-and-red-ginseng-variations-in-ginsenosides-and-immunomodulation
#17
Min He, Xin Huang, Shuying Liu, Chunsheng Guo, Yufei Xie, Annemarie H Meijer, Mei Wang
Ginseng Radix ( Panax ginseng ) is one of the most commonly used herbs worldwide for the treatment of inflammation-related diseases among others, supported by ancient historical records. Throughout this long history, the large-scale cultivation of ginseng created an increasing demand for long-term storage of the harvested plant material, accelerating the development of post-harvesting procedures. Dried white ginseng and processed (steamed) red ginseng are the products of the two most common traditional post-harvest processes...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29925100/six-new-neo-clerodane-diterpenoids-from-aerial-parts-of-scutellaria-barbata-and-their-cytotoxic-activities
#18
Guo-Chun Yang, Jia-Hui Hu, Bing-Long Li, Huan Liu, Jia-Yue Wang, Li-Xin Sun
Six new neo-clerodane diterpenoids (1: -6: ), scutebatas X - Z, A1 -C1 , along with twelve known ones (7: -18: ) were obtained via the phytochemical investigation of the aerial parts of Scutellaria barbata . Their structures were established by detailed spectroscopic analysis. The absolute configurations of 1: and 2: , as the representative members of this type, were identified based on a circular dichroic exciton chirality method. Moreover, in vitro cytotoxicity of compounds 1: -6: were evaluated against three human cancer cell lines (SGC-7901, MCF-7, and A-549) using the MTT method...
June 20, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913528/blood-pressure-and-cognitive-performance-after-a-single-administration-of-a-camphor-crataegus-combination-in-adolescents-with-low-blood-pressure
#19
Rainer Schandry, Daniela Lindauer, Matthias Mauz
Low blood pressure is rather widespread among adolescents and frequently accompanied by complaints. Two single-center, double-blinded, randomized, and placebo-controlled trials were performed with adolescent participants in the age range of 14 - 17 y having a systolic blood pressure below 118 mmHg (boys) or 110 mmHg (girls). They received a single dose of 20 drops of a fixed combination of natural D-camphor and an ethanolic extract from fresh Crataegus berries (CCC) or of an ethanolic placebo. The efficacy of CCC (commercial name Korodin) has proven its efficacy in the treatment of low blood pressure in adults of all ages, although related placebo-controlled, double-blind studies for adolescents following European (EU) pediatric regulations are lacking...
June 18, 2018: Planta Medica
https://www.readbyqxmd.com/read/29913527/antimicrobial-and-efflux-inhibitor-activity-of-usnic-acid-against-mycobacterium-abscessus
#20
Ivy B Ramis, Júlia S Vianna, Ana Júlia Reis, Andrea von Groll, Daniela F Ramos, Miguel Viveiros, Pedro E Almeida da Silva
New drugs are needed to treat infections with antimicrobial-resistant Mycobacterium abscessus ; therefore, we evaluated usnic acid as an antimicrobial agent and efflux inhibitor (EI) against M. abscessus . Usnic acid showed antimicrobial activity, and synergistically, the EI verapamil increased this activity. In addition, when we evaluated the interaction of antimicrobials with usnic acid, the increase of their activity was observed. Finally, usnic acid showed an efflux inhibitory effect between the classical EIs verapamil and carbonyl cyanide m-chlorophenylhydrazine...
June 18, 2018: Planta Medica
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