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Planta Medica

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https://www.readbyqxmd.com/read/29341031/getting-more-than-you-paid-for-unauthorized-natural-substances-in-herbal-food-supplements-on-eu-market
#1
Marijana Zovko Končić
As the population in the industrialized world develops preference for what is perceived as a natural and holistic way of disease treatment, the popularity and the number of food supplements on the market, including herbal ones, is experiencing an unprecedented rise. However, unlike herbal medicinal products, intended for treating or preventing disease, current legislation classifies food supplements as products intended for achieving nutritional or physiological effect and to supplement the normal diet. Accordingly, most food supplements are not to be associated with specific health claims...
January 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29341030/new-tirucallane-type-triterpenoids-from-guarea-guidonia
#2
Vanessa Hernandez, Marinella De Leo, Roberta Cotugno, Alessandra Braca, Nunziatina De Tommasi, Lorella Severino
The aerial parts of Guarea guidonia afforded three new tirucallane-type triterpenoids: 3,4-seco-tirucalla-4(28),8(9),24(25)-trien-7α,11α-dihydroxy-21,23-epoxy-3,11-olide, named guareolide (1: ), 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21-hydroxy-21,23-epoxy-3-oic acid, named guareoic acid A (2: ), and 3,4-seco-tirucalla-4(28),7(8),24(25)-trien-21,23-epoxy-3-oic acid, named guareoic acid B (3: ), of which 1: possessed an unusual seven-membered lactone ring. Seven known terpenes were also isolated and characterized as flindissone, 7-acetyldihydronomilin, picroquassin E, boscartol C, and cneorubins A, B, and X...
January 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29341029/in-vitro-and-in-situ-absorption-and-metabolism-of-sesquiterpenes-from-petasites-hybridus-extracts
#3
Lucia Disch, Kristina Forsch, Beate Siewert, Jürgen Drewe, Gert Fricker
Petasites hybridus extract is used in the treatment of seasonal allergic rhinitis. The aim of this study was to evaluate the active constituent petasin and its isomers isopetasin and neopetasin (petasins) in the P. hybridus extract Ze 339 for liberation, dissolution, absorption, and metabolism. The determination of pH-dependent thermodynamic solubility was performed via the shake-flask method. Petasins exhibited a low solubility that was pH independent. In vivo, the concentration of solute drugs is decreased continuously by intestinal absorption...
January 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29329463/ginsenoside-rh1-a-systematic-review-of-its-pharmacological-properties
#4
Dao Ngoc Hien Tam, Duy Hieu Truong, Thi Thanh Hoa Nguyen, Le Nhat Quynh, Linh Tran, Hong Duong Nguyen, Bahaa Eldin Shamandy, Thi Minh Huong Le, Dang Khoa Tran, Dina Sayed, Van Vinh Vu, Shusaku Mizukami, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29329462/silibinin-from-silybum-marianum-stimulates-embryonic-stem-cell-vascular-differentiation-via-the-stat3-pi3-k-akt-axis-and-nitric-oxide
#5
Enas Hussein Ali, Fatemeh Sharifpanah, Maria Wartenberg, Heinrich Sauer
Silibinin, the bioactive compound of milk thistle (Silybum marianum), exerts tissue protective and regenerative effects that may include stem cell differentiation toward vascular cells. The purpose of the present study was to investigate whether silibinin stimulates blood vessel formation from mouse embryonic stem (ES) cells and to unravel the underlying signaling cascade. Vascular branching points were assessed by confocal laser scanning microscopy and computer-assisted image analysis of CD31-positive cell structures...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29320799/new-phenylethanoid-glycosides-from-cistanche-phelypaea-and-their-activity-as-inhibitors-of-monoacylglycerol-lipase-magl
#6
Khadidja Aya Beladjila, Djemaa Berrehal, Nunziatina De Tommasi, Carlotta Granchi, Giulia Bononi, Alessandra Braca, Marinella De Leo
Four new phenylethanoid glycosides (1: -4: ), 1-β-p-hydroxyphenyl-ethyl-2-O-acetyl-3,6-di-α-l-rhamnopyranosyl-β-d-glucopyranoside (1: ), 1-β-p-hydroxyphenyl-ethyl-3,6-O-di-α-l-rhamnopyranosyl-β-d-glucopyranoside (2: ), 1-β-p-hydroxyphenyl-ethyl-2-O-acetyl-3,6-di-α-l-rhamnopyranosyl-4-p-coumaroyl-β-d-glucopyranoside (3: ), and 1-β-p-hydroxyphenyl-ethyl-3,6-di-α-l-rhamnopyranosyl-4-p-coumaroyl-β-d-glucopyranoside (4: ), together with three known compounds, were isolated from the n-butanol extract of Cistanche phelypaea aerial parts...
January 10, 2018: Planta Medica
https://www.readbyqxmd.com/read/29301148/current-perspectives-on-biotechnological-cannabinoid-production-in-plants
#7
Julia Schachtsiek, Heribert Warzecha, Oliver Kayser, Felix Stehle
The plant Cannabis sativa contains a number of psychoactive chemical compounds, the cannabinoids, which possess a significant pharmaceutical potential. Recently, the usage of Cannabis for medicinal purposes was legalized in many countries. Thus, the study on the influence of different cannabinoids in combination with other Cannabis-derived compounds with respect to the treatment of various diseases becomes increasingly important. Besides the production of distinct cannabinoids in a heterologous host, like tobacco or yeast, transgenic Cannabis plants would be a suitable alternative to modify and therefore optimize the cannabinoid profile...
January 4, 2018: Planta Medica
https://www.readbyqxmd.com/read/29301147/amentoflavone-inhibits-osteoclastogenesis-and-wear-debris-induced-osteolysis-via-suppressing-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways
#8
Zhen Zhang, Shuai Zhao, Xiaolei Li, Xiaoqi Zhuo, Wu Zhang, Qian Nie, Shuguang Wang, Lianqi Yan, Yu Sun
Wear debris-induced osteolysis is one of the major reasons for subsequent aseptic loosening after cementless hip arthroplasty. Increasing evidence suggests that receptor activator of nuclear factor kappa-B (NF-κB) ligand-mediated osteoclastogenesis and osteolysis are responsible for wear debris-induced aseptic loosening. In the present study, we explored the effect of amentoflavone (AMF) on inhibiting osteoclast generation and wear debris-induced osteolysis in vitro and in vivo. Twenty-four male C57BL/J6 mice were randomly divided into four groups: a sham group and groups with titanium wear debris treatment followed by intraperitoneal injection of various concentrations of AMF (0, 20, and 40 mg/kg/day)...
January 4, 2018: Planta Medica
https://www.readbyqxmd.com/read/29301146/a-self-microemulsifying-formulation-of-oxyresveratrol-prevents-amyloid-beta-protein-induced-neurodegeneration-in-mice
#9
Yaowaporn Sangsen, Thongchai Sooksawate, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Ruedeekorn Wiwattanapatapee
The polyphenol compound, oxyresveratrol (OXY) possesses potent antioxidant and neuroprotective properties of potential utility in the treatment of Alzheimer's disease. However, the low oral bioavailability limits its neuroprotective effect and clinical application. The neuroprotective effect of orally administered OXY-loaded self-microemulsifying drug delivery system (OXY-SMEDDS) was compared with free OXY in vivo. Mice were orally administered either free OXY or OXY-SMEDDS once daily at a dose of 90, 180, or 360 mg/kg for 14 d...
January 4, 2018: Planta Medica
https://www.readbyqxmd.com/read/29301145/effective-antimalarial-activities-of-%C3%AE-hydroxy-diynes-isolated-from-ongokea-gore
#10
Joséphine Kankolongo Ntumba, Christian Muamba Tshiongo, Michel Ngoma Mifundu, Raphäel Robiette, Kalulu Muzele Taba
Three diynes, octadec-17-ene-9,11-diynoate ethyl (1: ), 8-hydroxy-octadeca-13,17-diene-9,11-diynoate ethyl (2: ), and 8-hydroxy-octadec-13-ene-9,11-diynoate ethyl (3: ), were isolated from Ongokea gore seed oil. The structure assignment of these three compounds was based according to chemical and spectroscopic data. They were screened against Plasmodium falciparum, the parasite that causes malaria. In vitro micro-test (Mark III, supported by the World Health Organization) was developed to assess the response of P...
January 4, 2018: Planta Medica
https://www.readbyqxmd.com/read/29262425/quantitative-determination-of-%C3%AE-9-thc-cbg-cbd-their-acid-precursors-and-five-other-neutral-cannabinoids-by-uhplc-uv-ms
#11
Yan-Hong Wang, Bharathi Avula, Mahmoud A ElSohly, Mohamed M Radwan, Mei Wang, Amira S Wanas, Zlatko Mehmedic, Ikhlas A Khan
Cannabinoids are a group of terpenophenolic compounds in the medicinal plant Cannabis sativa (Cannabaceae family). Cannabigerolic acid, Δ9-tetrahydrocannabinolic acid A, cannabidiolic acid, Δ9-tetrahydrocannabinol, cannabigerol, cannabidiol, cannabichromene, and tetrahydrocannabivarin are major metabolites in the classification of different strains of C. sativa. Degradation or artifact cannabinoids cannabinol, cannabicyclol, and Δ8-tetrahydrocannabinol are formed under the influence of heat and light during processing and storage of the plant sample...
December 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/29253908/cytotoxic-deoxypodophyllotoxin-can-be-extracted-in-high-purity-from-anthriscus-sylvestris-roots-by-supercritical-carbon-dioxide
#12
Christel L C Seegers, Pieter G Tepper, Rita Setroikromo, Wim J Quax
Deoxypodophyllotoxin is present in the roots of Anthriscus sylvestris. This compound is cytotoxic on its own, but it can also be converted into podophyllotoxin, which is in high demand as a precursor for the important anticancer drugs etoposide and teniposide. In this study, deoxypodophyllotoxin is extracted from A. sylvestris roots by supercritical carbon dioxide extraction. The process is simple and scalable. The supercritical carbon dioxide method extracts 75 - 80% of the total deoxypodophyllotoxin content, which is comparable to a single extraction by traditional Soxhlet...
December 18, 2017: Planta Medica
https://www.readbyqxmd.com/read/29237190/determination-of-acid-and-neutral-cannabinoids-in-extracts-of-different-strains-of-cannabis-sativa-using-gc-fid
#13
Elsayed A Ibrahim, Waseem Gul, Shahbaz W Gul, Brandon J Stamper, Ghada M Hadad, Randa A Abdel Salam, Amany K Ibrahim, Safwat A Ahmed, Suman Chandra, Hemant Lata, Mohamed M Radwan, Mahmoud A ElSohly
Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) are the two major phytocannabinoids accounting for over 40% of the cannabis plant extracts, depending on the variety. At the University of Mississippi, different strains of C. sativa, with different concentration ratios of CBD and Δ9-THC, have been tissue cultured via micropropagation and cultivated. A GC-FID method has been developed and validated for the qualitative and quantitative analysis of acid and neutral cannabinoids in C...
December 13, 2017: Planta Medica
https://www.readbyqxmd.com/read/29220861/do-we-need-plant-food-supplements-a-critical-examination-of-quality-safety-efficacy-and-necessity-for-a-new-regulatory-framework
#14
Mona Abdel-Tawab
Given the expanding market of plant food supplements (PFSs) not undergoing any pre-marketing authorization, the overall quality, safety and efficacy of PFSs were subjected to a critical examination. Although many high-quality PFSs exist on the legal market, quality concerns are in general justified. Besides economic adulteration, active ingredients dramatically differing from label claims and among products were reported in several studies. In addition, PFSs sold via the Internet may be intentionally adulterated with undeclared prescription drugs...
December 8, 2017: Planta Medica
https://www.readbyqxmd.com/read/29216668/characteristic-chromatogram-a-method-of-discriminate-and-quantitative-analysis-for-quality-evaluation-of-uncaria-stem-with-hooks
#15
Jinjun Hou, Ruihong Feng, Yibei Zhang, Huiqin Pan, Shuai Yao, Sumei Han, Zijin Feng, Luying Cai, Wanying Wu, De-An Guo
It remains a challenge to establish new monographs for herbal drugs derived from multiple botanical sources. Specifically, the difficulty involves discriminating and quantifying these herbs with components whose levels vary markedly among different samples. Using Uncaria stem with hooks as an example, a characteristic chromatogram was proposed to discriminate its five botanical origins and to quantify its characteristic components in the chromatogram. The characteristic chromatogram with respect to the components of Uncaria stem with hooks with the five botanical origins was established using 0...
December 7, 2017: Planta Medica
https://www.readbyqxmd.com/read/29202513/new-pharmacological-opportunities-for-betulinic-acid
#16
José Luis Ríos, Salvador Máñez
Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29202512/a-simple-and-rapid-uplc-pda-method-for-quality-control-of-nardostachys-jatamansi
#17
Weize Zhang, Guo Nan, Hong-Hua Wu, Miaomiao Jiang, Tian-Xiang Li, Meng Wang, Xiu-Mei Gao, Yan Zhu, Yun Seon Song, Jiaming Wang, Yan-Tong Xu
Nardostachys jatamansi is a well-documented herbal agent used to treat digestive and neuropsychiatric disorders in oriental medicinal systems. However, few simple, rapid, and comprehensive methods were reported for quality assessment and control of N. jatamansi. Herein, a UPLC with photodiode array detection method was developed for both fingerprint investigation of N. jatamansi and simultaneous quantitative analysis of the six serotonin transporter modulatory constituents in N. jatamansi. For chromatographic fingerprinting, 24 common peaks were selected as characteristic peaks to assess the consistency of N...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29202511/in-vitro-anti-inflammatory-effects-of-equisetum-arvense-are-not-solely-mediated-by-silica
#18
Carmen Steinborn, Olivier Potterat, Ulrich Meyer, Rainer Trittler, Sven Stadlbauer, Roman Huber, Carsten Gründemann
Equisetum arvense, known as common horsetail, is used for the treatment of inflammatory diseases and is the plant with the highest concentration of silica. Yet it is unknown if the medicinal properties are mediated by its silica content. In the current study, optimal conditions for silica-rich horsetail preparations were identified. Bioactivity of the preparations was analyzed in vitro using flow cytometry-based activity and functionality profiling of primary human lymphocytes as well as cytokine measurement using a classical ELISA technique...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29202510/extraction-method-and-analysis-of-cannabinoids-in-cannabis-olive-oil-preparations
#19
Antonella Casiraghi, Gabriella Roda, Eleonora Casagni, Cecilia Cristina, Umberto Maria Musazzi, Silvia Franzè, Paolo Rocco, Claudia Giuliani, Gelsomina Fico, Paola Minghetti, Veniero Gambaro
Recently, an increasing number of pharmacists had to supply medicinal products based on Cannabis sativa L. (Cannabaceae), prescribed by physicians to individual patients. Cannabis olive oil preparation is the first choice as a concentrated extract of cannabinoids, even though standardized operative conditions for obtaining it are still not available. In this work, the impact of temperature and extraction time on the concentration of active principles was studied to harmonize the different compounding methods, optimize the extraction process, and reduce the variability among preparations...
December 4, 2017: Planta Medica
https://www.readbyqxmd.com/read/29179245/anti-inflammatory-effects-of-canthin-6-one-alkaloids-from-ailanthus-altissima
#20
Seung-Kye Cho, Miran Jeong, Dae Sik Jang, Jung-Hye Choi
Canthin-6-one (CO) alkaloids possess various biological activities, including antibacterial, antitumor, antifungal, and antiviral activities. However, their anti-inflammatory effects and underlying molecular mechanisms are poorly characterized. This study aimed to investigate the anti-inflammatory effects of CO and its derivative 5-(1-hydroxyethyl)-canthin-6-one (5-HCO), isolated from the stem barks of Ailanthus altissima in lipopolysaccharide (LPS)-stimulated macrophages. CO (1 and 5 µM) and 5-HCO (7.5 and 15 µM) significantly inhibited the LPS-induced expression of inducible nitric oxide synthase...
November 27, 2017: Planta Medica
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