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Planta Medica

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https://www.readbyqxmd.com/read/28095587/quantitative-determination-of-lactones-in-piper-methysticum-kava-kava-by-supercritical-fluid-chromatography
#1
Adele Murauer, Markus Ganzera
A fast and validated supercritical fluid chromatography method for the quantitative determination of major lactones in Piper methysticum, a plant used against nervous anxiety, stress, and restlessness, was developed. The baseline separation of dihydrokavain, demethoxyyangonin, kavain, yangonin, dihydromethysticin, and methysticin was possible in less than 4 min on an Aquity UPC(2) BEH 1.7 µm column, in combination with a mobile phase comprising CO2 and methanol with diethylamine. The column temperature had a great impact on the results because only at 70 °C could kavain and yangonin be fully resolved...
January 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/28095586/antichlamydial-dimeric-indole-derivatives-from-marine-actinomycete-rubrobacter-radiotolerans
#2
Jian Lin Li, Dandan Chen, Lei Huang, Min Ni, Yu Zhao, Huizhou Fan, Xiaofeng Bao
Chlamydiae are widely distributed pathogens of human populations, which can lead to serious reproductive and other health problems. In our search for novel antichlamydial metabolites from marine derived-microorganisms, one new (1) and two known (2, 3) dimeric indole derivatives were isolated from the sponge-derived actinomycete Rubrobacter radiotolerans. The chemical structures of these metabolites were elucidated by NMR spectroscopic data as well as CD calculations. All three metabolites suppressed chlamydial growth in a concentration-dependent manner...
January 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/28081580/biosynthetic-studies-on-acetosellin-and-structure-elucidation-of-a-new-acetosellin-derivative
#3
Peter Hufendiek, Simon Stephan Martin Stölben, Stefan Kehraus, Nicole Merten, Henrik Harms, Max Crüsemann, Idris Arslan, Michael Gütschow, Tanja Schneider, Gabriele Maria König
Natural products from fungi, especially Ascomycota, play a major role in therapy and drug discovery. Fungal strains originating from marine habitats offer a new avenue for finding unusual molecular skeletons. Here, the marine-derived fungus Epicoccum nigrum (strain 749) was found to produce the azaphilonoid compounds acetosellin and 5',6'-dihydroxyacetosellin. The latter is a new natural product. The biosynthesis of these polyketide-type compounds is intriguing, since two polyketide chains are assembled to the final product...
January 12, 2017: Planta Medica
https://www.readbyqxmd.com/read/28073120/nano-pelargonidin-protects-hyperglycemic-induced-l6-cells-against-mitochondrial-dysfunction
#4
Asmita Samadder, Debojyoti Tarafdar, Suresh K Abraham, Kumaresh Ghosh, Anisur Rahman Khuda-Bukhsh
Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to produce nano-pelargonidin. Size, morphology, zeta potential, and planar uniformity of formulated nano-pelargonidin were determined by atomic force microscopy and dynamic light scattering. The time required for cellular entry, folds of nano-pelargonidin, and drug encapsulation efficiency of poly-lactide-co-glycolic-acid were also ascertained...
January 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28073119/in-vitro-inhibition-of-human-cyp450s-1a2-2c9-3a4-5-2d6-and-2e1-by-grandisin
#5
Maísa Daniela Habenschus, Fernanda de Lima Moreira, Norberto Peporine Lopes, Anderson R M de Oliveira
Grandisin, a lignan isolated from many species of plants, such as Virola surinamensis, is a potential drug candidate due to its biological properties, highlighted by its antitumor and trypanocidal activities. In this study, the inhibitory effects of grandisin on the activities of human cytochrome P450 enzymes were investigated by using human liver microsomes. Results showed that grandisin is a competitive inhibitor of CYP2C9 and a competitive and mechanism-based inhibitor of CYP3A4/5. The apparent Ki value for CYP2C9 was 50...
January 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28073118/in-vitro-metabolism-of-artepillin-c-by-rat-and-human-liver-microsomes
#6
Daniel Blascke Carrão, Nayara Cristina Perez de Albuquerque, Lucas Maciel Mauriz Marques, Antônio Eduardo Miller Crotti, Alan Cesar Pilon, Vanderlan Da Silva Bolzani, Andresa Aparecida Berretta, Anderson Rodrigo Moraes de Oliveira
Artepillin C, a natural product present in the Brazilian green propolis, has several biological properties. Among these properties, the antitumor action of this product is noteworthy and makes it a promising drug candidate for the treatment of several types of cancer. This paper describes the in vitro metabolism of Artepillin C in rat and human liver microsomes. The rat model suggested a sigmoidal profile for the metabolism, adapted to the Hill's kinetic model. The enzymatic kinetic parameters were as follows: maximal velocity = 0...
January 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28068726/erratum-naphthoquinones-from-onosma-paniculatum-with-potential-anti-inflammatory-activity
#7
Miao Dong, Dan Liu, Yan-Hong Li, Xuan-Qin Chen, Kai Luo, Yong-Min Zhang, Rong-Tao Li
No abstract text is available yet for this article.
January 9, 2017: Planta Medica
https://www.readbyqxmd.com/read/28010025/evodiamine-prevents-isoproterenol-induced-cardiac-fibrosis-by-regulating-endothelial-to-mesenchymal-transition
#8
Xiao-Han Jiang, Qing-Qing Wu, Yang Xiao, Yuan Yuan, Zheng Yang, Zhou-Yan Bian, Wei Chang, Qi-Zhu Tang
Evodiamine, a major component of Evodia rutaecarpa, can protect the myocardium against injury induced by atherosclerosis and ischemia-reperfusion. However, the effect of evodiamine against cardiac fibrosis remains unclear. This study aims to investigate the possible effect and mechanism involved in the function of evodiamine on isoproterenol-induced cardiac fibrosis and endothelial-to-mesenchymal transition. Isoproterenol was used to induce cardiac fibrosis in mice, and evodiamine was gavaged simultaneously...
December 23, 2016: Planta Medica
https://www.readbyqxmd.com/read/28006833/triterpenoids-with-antiplatelet-aggregation-activity-from-the-roots-of-ilex-pubescens
#9
Qinglong Tan, Maosong Qiu, Di Cao, Tianqin Xiong, Lei Zhang, Lian Zhou, Li Rong, Jinsong Zhou, Jing Jin, Zhongxiang Zhao
Two new triterpenes and five new triterpene saponins, named ilexpusons A-G (1-7), as well as eight known compounds were isolated from Ilex pubescens. The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS, (1)H-NMR, (13)C-NMR, (1)H-(1)H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds 1 - 15 against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined. Among the tested compounds, 1, 2, 5, 6, 8, 13, 14, and 15 exhibited significant inhibition of platelet aggregation in vitro...
December 22, 2016: Planta Medica
https://www.readbyqxmd.com/read/28006832/the-dual-edema-preventing-molecular-mechanism-of-the-crataegus-extract-ws-1442-can-be-assigned-to-distinct-phytochemical-fractions
#10
Simone Fuchs, Iris Bischoff, Elisabeth A Willer, Jacqueline Bräutigam, Martin F Bubik, Clemens A J Erdelmeier, Egon Koch, Maria T Faleschini, Maria De Mieri, Milena Bauhart, Stefan Zahler, Andreas Hensel, Matthias Hamburger, Olivier Potterat, Robert Fürst
The hawthorn (Crataegus spp.) extract WS 1442 is used against mild forms of chronic heart failure. This disease is associated with endothelial barrier dysfunction and edema formation. We have recently shown that WS 1442 protects against this dysfunction by a dual mechanism: it both promotes endothelial barrier integrity by activation of a barrier-enhancing pathway (cortactin activation) and inhibits endothelial hyperpermeability by blocking a barrier disruptive pathway (calcium signaling). In this study, we aimed to identify the bioactive compounds responsible for these actions by using a bioactivity-guided fractionation approach...
December 22, 2016: Planta Medica
https://www.readbyqxmd.com/read/27997959/parthenolide-modulates-immune-response-in-cells-from-c57bl-6-mice-induced-with-experimental-autoimmune-encephalomyelitis
#11
Lara Soares Aleixo de Carvalho, Lívia Beatriz Almeida Fontes, Matheus Coutinho Gazolla, Débora Dos Santos Dias, Maria Aparecida Juliano, Gilson Costa Macedo, José Otávio do Amaral Corrêa, Ademar A Da Silva Filho
Multiple sclerosis is a chronic inflammatory and autoimmune disease of the central nervous system that affects more than 2.5 million people worldwide. Experimental autoimmune encephalomyelitis is a murine autoimmune disease used to study multiple sclerosis. Parthenolide, a natural sesquiterpene lactone found in Tanacetum parthenium L., is known for its strong anti-inflammatory activity. Herein, we have investigated the in vitro immunomodulatory effects of parthenolide on cytokine production and nitric oxide in cultured cells from myelin oligodendrocyte glycoprotein 35-55 amino acid peptide mice...
December 20, 2016: Planta Medica
https://www.readbyqxmd.com/read/27992941/comparative-analysis-of-ultrafine-granular-powder-and-decoction-pieces-of-salvia-miltiorrhiza-by-uplc-uv-msn-combined-with-statistical-analysis
#12
Yao Shen, Jinjun Hou, Wen Deng, Zijin Feng, Min Yang, Jinle Cheng, Wanying Wu, De-An Guo
Salvia miltiorrhiza is one of the most used herbal medicines for the treatment of a wide range of diseases in China. Decoction pieces and Chinese patent medicines from S. miltiorrhiza are the two main types of products used by patients. Other relatively new products of S. miltiorrhiza, like injections and ultrafine granular powder (D90 < 45 µm before granulation), are also increasingly used nowadays. With the growing usage of new products of S. miltiorrhiza, their chemical components and pharmacological effects, compared to the traditional decoction pieces, are attracting attention...
December 19, 2016: Planta Medica
https://www.readbyqxmd.com/read/27992940/pharmacokinetics-of-a-standardized-extract-of-centella-asiatica-eca-233-in-rats
#13
Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot
ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intravenously or orally administered at doses from 50 to 200 mg/kg. Plasma, tissues, urine, and feces were collected at time points from 0 to 48 h after dosing. The levels of madecassoside and asiaticoside, as well as their postulated triterpenic metabolites, madecassic acid and asiatic acid, in biological samples, were simultaneously measured by liquid chromatography-tandem mass spectrometry...
December 19, 2016: Planta Medica
https://www.readbyqxmd.com/read/27992939/antiobesity-and-lipid-lowering-effects-of-orthosiphon-stamineus-in-high-fat-diet-induced-obese-mice
#14
Atefehalsadat Seyedan, Mohammed Abdullah Alshawsh, Mustafa Ahmed Alshagga, Zahurin Mohamed
The present study investigated the antiobesity and lipid lowering effects of an ethanolic extract of leaves obtained from Orthosiphon stamineus (200 and 400 mg/kg) and its major compound (rosmarinic acid, 10 mg/kg) in obese mice (C57BL/6) induced by a high-fat diet. Continuous supplementation with O. stamineus extract (200 and 400 mg/kg) for 8 weeks significantly decreased body weight gain (p < 0.05). However, supplementation with rosmarinic acid, a constituent in the extract, produced only a slight reduction in body weight gain compared to the high-fat diet control group...
December 19, 2016: Planta Medica
https://www.readbyqxmd.com/read/28099987/a-big-thank-you-to-our-reviewers-in-the-past-year
#15
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Planta Medica
https://www.readbyqxmd.com/read/28099986/editorial
#16
Veronika Butterweck
No abstract text is available yet for this article.
January 2017: Planta Medica
https://www.readbyqxmd.com/read/27976359/impuls-lecture-looking-for-plant-bioactive-compound-target-uno-nessuno-o-centomila
#17
F Dal Piaz
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976358/a-comparative-metagenomics-approach-to-marine-natural-product-drug-discovery-in-hippospongia-lachne
#18
I J Miller, J G Lopera, K Montgomery, W Rose, J C Kwan
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976357/anti-inflammatory-and-anti-anaphylactic-activity-of-xylopic-acid-isolated-from-the-dried-fruit-of-xylopia-aethiopica-in-mice
#19
N Osafo, D D Obiri
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976356/molecular-phylogenetics-as-a-predictive-tool-in-plant-based-drug-discovery-in-the-genus-euphorbia-l
#20
M Ernst, C H Saslis-Lagoudakis, O M Grace, N Nilsson, H Toft Simonsen, J W Horn, D Stærk, N Rønsted
No abstract text is available yet for this article.
December 2016: Planta Medica
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