journal
MENU ▼
Read by QxMD icon Read
search

Planta Medica

journal
https://www.readbyqxmd.com/read/28301880/fast-and-green-co2-based-extraction-isolation-and-quantification-of-phenolic-styrax-constituents
#1
Johanna Scheuba, Valerie-Katharina Wronski, Judith M Rollinger, Ulrike Grienke
In this study the first supercritical fluid based protocol for the extraction, analysis, and isolation of six polar compounds, i.e., o-vanillin (1), styracin (2), vanillin (3), trans-cinnamic acid (4), vanillic acid (5), and shikimic acid (6), was developed. First, eight styrax resin products (R1-R8) obtained from various Liquidambar tree species, which are known to contain compounds 2-6, were extracted with a 1 : 1 mixture of supercritical CO2 and EtOH. Within 4 minutes, the compounds were successfully baseline separated on an Acquity UPC(2) BEH 2-EP (3...
March 16, 2017: Planta Medica
https://www.readbyqxmd.com/read/28297727/new-knowledge-about-old-drugs-the-anti-inflammatory-properties-of-cardiac-glycosides
#2
Robert Fürst, Ilse Zündorf, Theo Dingermann
In the 19th century, cardio-active steroid glycosides, shortly cardiac glycosides, were scientifically established as drugs against heart failure. Their in vivo, cellular, and molecular actions as well as their predominant target, Na(+)-K(+)-ATPase, have been comprehensively investigated in the 20th century and the discovery of endogenous cardiac glycosides has fostered this research field. In the last years, however, results from clinical trials and meta-analyses have questioned their therapeutic value due to efficacy and safety issues...
March 15, 2017: Planta Medica
https://www.readbyqxmd.com/read/28291990/medicinal-plants-in-the-treatment-of-colitis-evidence-from-preclinical-studies
#3
Marília T Santana, Luana M Cercato, Janaíne P Oliveira, Enilton A Camargo
Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using "medicinal plants" and "ulcerative colitis" as key words...
March 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28288493/inhibitory-effects-of-garcinia-cambogia-extract-on-cyp2b6-enzyme-activity
#4
Jun Sang Yu, Min Sun Choi, Jong Suk Park, Shaheed Ur Rehman, Katsunori Nakamura, Hye Hyun Yoo
This study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner...
March 13, 2017: Planta Medica
https://www.readbyqxmd.com/read/28288492/correlating-in-vitro-target-oriented-screening-and-docking-inhibition-of-matrix-metalloproteinases-activities-by-flavonoids
#5
Lucia Crascì, Livia Basile, Annamaria Panico, Carmelo Puglia, Francesco P Bonina, Pierluigi Maria Basile, Luisa Rizza, Salvatore Guccione
Metalloproteases are a family of zinc-containing endopeptidases involved in a variety of pathological disorders. The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking...
March 13, 2017: Planta Medica
https://www.readbyqxmd.com/read/28264206/chamomile-flower-myrrh-and-coffee-charcoal-components-of-a-traditional-herbal-medicinal-product-diminish-proinflammatory-activation-in-human-macrophages
#6
Cica Vissiennon, Dima Hammoud, Steffen Rodewald, Karin Fester, Karl-Heinz Goos, Karen Nieber, Jürgen Arnhold
A traditional herbal medicinal product, containing myrrh, chamomile flower, and coffee charcoal, has been used in Germany for the relief of gastrointestinal complaints for decades. Clinical studies suggest its use in the maintenance therapy of inflammatory bowel disease. However, the pharmacological mechanisms underlying the clinical effects are not yet fully understood.The present study aims to elucidate immunopharmacological activities of myrrh, chamomile flower, and coffee charcoal by studying the influence of each plant extract on gene expression and protein release of activated human macrophages...
March 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28264205/chemical-composition-antiprotozoal-and-cytotoxic-activities-of-indole-alkaloids-and-benzofuran-neolignan-of-aristolochia-cordigera
#7
Marcos D P Pereira, Tito da Silva, Anna Caroline C Aguiar, Glaucius Oliva, Rafael V C Guido, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana, Lucia M X Lopes
This is a comparative study on the intraspecific chemical variability of Aristolochia cordigera species, collected in two different regions of Brazil, Biome Cerrado (semiarid) and Biome Amazônia (coastal). The use of GC-MS and statistical methods led to the identification of 56 compounds. A higher percentage of palmitone and germacrene-D in the hexanes extracts of the leaves of plants from these respective biomes was observed. Phytochemical studies on the extracts led to the isolation and identification of 19 known compounds, including lignans, neolignans, aristolochic acids, indole-β-carboline, and indole alkaloids...
March 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28264204/new-curcumin-loaded-chitosan-nanocapsules-in-vivo-evaluation
#8
Edgar Marin, Maria Isabel Briceño, Alicia Torres, Catherina Caballero-George
The medicinal applications of curcumin, the major component of Curcuma longa, are limited by its poor solubility and low oral bioavailability. In order to overcome this limitation, a method to produce nanocapsules of chitosan loaded with curcumin was developed. Three different molecular weight and deacetylation degree chitosan polymers were used in the formulation in order to prepare curcumin-loaded nanocapsules (mass ratio 1 : 1.4). The best results were achieved using chitosan-Bi with a molecular weight of 710 000 Da...
March 6, 2017: Planta Medica
https://www.readbyqxmd.com/read/28249303/clinical-parameters-following-multiple-oral-dose-administration-of-a-standardized-andrographis-paniculata-capsule-in-healthy-thai-subjects
#9
Tawit Suriyo, Nanthanit Pholphana, Teerapat Ungtrakul, Nuchanart Rangkadilok, Duangchit Panomvana, Apinya Thiantanawat, Wanwisa Pongpun, Jutamaad Satayavivad
Andrographis paniculata has been widely used in Scandinavian and Asian counties for the treatment of the common cold, fever, and noninfectious diarrhea. The present study was carried out to investigate the physiological effects of short-term multiple dose administration of a standardized A. paniculata capsule used for treatment of the common cold and uncomplicated upper respiratory tract infections, including blood pressure, electrocardiogram, blood chemistry, hematological profiles, urinalysis, and blood coagulation in healthy Thai subjects...
March 1, 2017: Planta Medica
https://www.readbyqxmd.com/read/28249302/which-bay-leaf-is-in-your-spice-rack-a-quality-control-study
#10
Vijayasankar Raman, Rainer W Bussmann, Ikhlas A Khan
The accurate identification of bay leaf in natural products commerce may often be confusing as the name is applied to several different species of aromatic plants. The true "bay leaf", also known as "bay laurel" or "sweet bay", is sourced from the tree Laurus nobilis, a native of the Mediterranean region. Nevertheless, the leaves of several other species including Cinnamomum tamala, Litsea glaucescens, Pimenta racemosa, Syzygium polyanthum, and Umbellularia californica are commonly substituted or mistaken for true bay leaves due to their similarity in the leaf morphology, aroma, and flavor...
March 1, 2017: Planta Medica
https://www.readbyqxmd.com/read/28249301/recombinant-human-acidic-fibroblast-growth-factor-afgf-expressed-in-nicotiana-benthamiana-potentially-inhibits-skin-photoaging
#11
Jang-Ho Ha, Ha-Neul Kim, Ki-Beom Moon, Jae-Heung Jeon, Dai-Hyun Jung, Su-Jung Kim, Hugh S Mason, Seo-Yeon Shin, Hyun-Soon Kim, Kyung-Mok Park
Responding to the need for recombinant acidic fibroblast growth factor in the pharmaceutical and cosmetic industries, we established a scalable expression system for recombinant human aFGF using transient and a DNA replicon vector expression in Nicotiana benthamiana. Recombinant human-acidic fibroblast growth factor was recovered following Agrobacterium infiltration of N. benthamiana. The optimal time point at which to harvest recombinant human acidic fibroblast growth factor expressing leaves was found to be 4 days post-infiltration, before necrosis was evident...
March 1, 2017: Planta Medica
https://www.readbyqxmd.com/read/28219095/kaempferol-attenuates-cardiac-hypertrophy-via-regulation-of-ask1-mapk-signaling-pathway-and-oxidative-stress
#12
Hong Feng, Jianlei Cao, Guangyu Zhang, Yanggan Wang
Kaempferol has been demonstrated to provide benefits for the treatment of atherosclerosis, coronary heart disease, hyperlipidemia, and diabetes through its antioxidant and anti-inflammatory properties. However, its role in cardiac hypertrophy remains to be elucidated. The aim of our study was to investigate the effects of kaempferol on cardiac hypertrophy and the underlying mechanism. Mice subjected to aorta banding were treated with or without kaempferol (100 mg/kg/d, p. o.) for 6 weeks. Echocardiography was performed to evaluate cardiac function...
February 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/28196382/bromelain-loading-and-release-from-a-hydrogel-formulated-using-alginate-and-arabic-gum
#13
Janaína Artem Ataide, Letícia Caramori Cefali, Marcia de Araujo Rebelo, Lívia Genovez Spir, Elias Basile Tambourgi, Angela Faustino Jozala, Marco Vinícius Chaud, Edgar Silveira, Xiaochen Gu, Priscila Gava Mazzola
An ideal wound dressing ensures a moist environment around the wound area and absorbs exudates from the wound surface. Topical application of bromelain to incised wounds has been shown to reprogram the wound microenvironment to promote effective tissue repair. Combining the characteristics of hydrogels and bromelain is therefore of great interest. Herein, we describe the development of a hydrogel, formulated using alginate and Arabic gum, for bromelain loading and release. The hydrogel formulation was evaluated using response surface methodology, considering the pH value and the concentration of alginate and Arabic gum...
February 14, 2017: Planta Medica
https://www.readbyqxmd.com/read/28192813/passive-intestinal-absorption-of-representative-plant-secondary-metabolites-a-physicochemical-study
#14
Charlotte Petit, Martina Ceccarelli, Sylvian Cretton, Joëlle Houriet, Krystyna Skalicka-Woźniak, Philippe Christen, Pierre-Alain Carrupt, Laura Goracci, Jean-Luc Wolfender
Natural products are generally ingested as part of traditional herbal decoctions or in the current diet. However, in natural product research, the bioavailability of secondary metabolites is often poorly investigated. In this work, a systematic study was carried out in order to highlight the physicochemical parameters that mainly influence the passive intestinal absorption of natural products. For this, a representative set of natural products including alkaloids, coumarins, flavonoid aglycones and glycosides, and carboxylic acids was selected and their physicochemical properties were predicted using relevant Volsurf+ descriptors...
February 13, 2017: Planta Medica
https://www.readbyqxmd.com/read/28187468/development-of-an-enzyme-linked-immunosorbent-assay-for-determination-of-miroestrol-using-an-anti-miroestrol-monoclonal-antibody
#15
Tharita Kitisripanya, Supaluk Krittanai, Orapin Udomsin, Kamonthip Jutathis, Jukrapun Komaikul, Thaweesak Juengwatanatrakul, Seiichi Sakamoto, Hiroyuki Tanaka, Satoshi Morimoto, Waraporn Putalun
Miroestrol is a chromene with potent estrogenic activity present in Pueraria candollei, commonly known as White Kwao Krua. Although this compound is only present in low amounts in the plant, it plays an important role in the estrogenic action of P. candollei products. As a tool for further studies about the efficacy and safety of P. candollei as a phytoestrogenic supplement, we generated a novel monoclonal antibody against miroestrol. This anti-miroestrol monoclonal antibody was used to develop an immunoassay for the determination of miroestrol content, which can be used for quality control purposes of P...
February 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28187467/protective-effects-of-ellagic-acid-on-cardiovascular-injuries-caused-by-hypertension-in-rats
#16
Juliana Bahia Reis Jordão, Hellen Karine Paes Porto, Flávio Marques Lopes, Aline Carvalho Batista, Matheus Lavorenti Rocha
Ellagic acid is described as having antioxidant and antiproliferative properties. Hence, it was hypothesized that ellagic acid could improve cardiovascular damage caused by hypertension. In this work, hypertension was induced in rats with Nω-Nitro-L-arginine methyl ester hydrochloride (60 mg/kg/day in drinking water) for 6 weeks. Ellagic acid was coadministered (10 or 30 mg/kg/day by gavage) between the second and sixth week. Blood pressure was recorded every week by tail-cuff plethysmography. After 6 weeks, the rats were sacrificed, the hearts and kidneys were weighed, and blood was collected...
February 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28187466/effects-of-mangifera-indica-careless-on-microcirculation-and-glucose-metabolism-in-healthy-volunteers
#17
Sybille Buchwald-Werner, Christiane Schön, Sonja Frank, Claudia Reule
A commercial Mangifera indica fruit powder (Careless) showed beneficial acute effects on microcirculation in a randomized, double-blind, crossover pilot study. Here, long-term effects on microcirculation and glucose metabolism were investigated in a double-blind, randomized, placebo-controlled, 3-arm parallel-design study in healthy individuals. A daily dose of 100 mg or 300 mg of the fruit powder was compared to placebo after supplementation for 4 weeks. Microcirculation and endothelial function were assessed by the Oxygen-to-see System and pulse amplitude tonometry, respectively...
February 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28158891/four-new-xanthones-from-cratoxylum-cochinchinense-and-their-in-vitro-antiproliferative-effects
#18
Chihiro Ito, Takuya Matsui, Ai Niimi, Hugh T-W Tan, Masataka Itoigawa
The study of the chemical constituents of branches and twigs of Cratoxylum cochinchinense collected in Singapore led to the isolation and structural elucidation of four new xanthones, named cratoxanthone A (1), B (2), C (3), and D (4), together with six known xanthones (5-10) and one known dihydroanthracenone (11). Eight xanthones (including 1 and 2) and 11 were tested for their antiproliferative activity in three human carcinoma cell lines (lung adenocarcinoma A549, colorectal carcinoma Colo205, and epidermoid carcinoma KB) and a human acute lymphoblastic leukemia B cell line (NALM-6), and the mitochondrial membrane potential was determined in KB cells...
February 3, 2017: Planta Medica
https://www.readbyqxmd.com/read/28152554/in-vitro-and-in-vivo-study-of-the-gastrointestinal-absorption-and-metabolisation-of-hymenocardine-a-cyclopeptide-alkaloid
#19
Emmy Tuenter, Sebastiaan Bijttebier, Kenn Foubert, Annelies Breynaert, Sandra Apers, Nina Hermans, Luc Pieters
Hymenocardine is a cyclopeptide alkaloid present in the root bark of Hymenocardia acida. In traditional African medicine, the leaves and roots of this plant are used to treat malaria, and moderate in vitro antiplasmodial activity has been reported for hymenocardine. However, in view of its peptide-like nature, potential metabolisation after oral ingestion has to be taken into account when considering in vivo experiments. In this study, the stability and small intestinal absorption of hymenocardine was assessed using an in vitro gastrointestinal dialysis model...
February 2, 2017: Planta Medica
https://www.readbyqxmd.com/read/28135738/in-vitro-and-in-vivo-anti-inflammatory-effects-of-struthanthus-vulgaris
#20
Franciane Martins Marques, Maycow Rodrigues da Costa, Cátia Vittorazzi, Luciane De Souza Dos Santos Gramma, Thiago Barth, Tadeu Uggere de Andrade, Denise Coutinho Endringer, Rodrigo Scherer, Marcio Fronza
Struthanthus vulgaris is probably the most common medicinal mistletoe plant in Brazil, and has been used in folk medicine as an anti-inflammatory agent and for cleaning skin wounds. Our proposal was to evaluate the anti-inflammatory activity of S. vulgaris ethanol leaf extract and provide further insights of how this biological action could be explained using in vitro and in vivo assays. In vitro anti-inflammatory activity was preliminarily investigated in lipopolysaccharide/interferon gamma-stimulated macrophages based on their ability to inhibit nitric oxide production and tumor necrosis factor-alpha...
January 30, 2017: Planta Medica
journal
journal
21510
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"