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Planta Medica

Francyelle Borges Rosa de Moura, Allisson Benatti Justino, Bruno Antonio Ferreira, Foued Salmen Espindola, Fernanda de Assis Araújo, Tatiana Carla Tomiosso
A polyphenol-enriched fraction from Annona crassiflora fruit peel (PEF-Ac) containing chlorogenic acid, epi-catechin, procyanidins B2 and C1, quercetin-glucoside, kaempferol, and caffeoyl-glucoside was investigated for its anti-inflammatory, pro-angiogenic, and profibrogenic potential in the healing of cutaneous wounds. Four wounds were performed on the back of C57 mice and the lesions were treated with the vehicle (Vaseline and lanolin) and PEF-Ac at concentrations of 2%, 4%, and 6% for 4 and 7 d. Neutrophils and macrophages activities were evaluated indirectly by the activity of myeloperoxidase and N-acetyl- β -D-glycosaminidase, angiogenesis was evaluated by hemoglobin dosing and vessel count in histological sections, and collagen deposition was assessed from histological sections stained with picrosirius red...
September 20, 2018: Planta Medica
Qiang-Qiang Shi, Wei-Hua Wang, Jing Lu, Da-Shan Li, Lin Zhou, Ming-Hua Qiu
One new 15,16-seco-cycloartane triterpene (1: ), three new cycloartane triterpene glycosides (2: -4: ), and five known compounds (5: -9: ) were isolated from the aerial parts of Actaea heracleifolia. The chemical structures of these compounds were determined on the basis of NMR analysis, HRTOF-ESIMS data, and other spectroscopic methods. Selected compounds were evaluated for their cytotoxicity against human tumor cell lines (HL-60, SMMC-7721, A549, MCF-7, and SW480) in vitro . Compounds 3: and 4: showed weak activity against the HL-60, A-549, and MCF-7 cell lines with IC50 values ranging from 21...
September 19, 2018: Planta Medica
Hisahiro Kai, Yoshihiro Uesawa, Hisato Kunitake, Kazuhiro Morishita, Yoshihito Okada, Koji Matsuno
Metabolic profiling is often used to identify possible correlations between a compound's metabolic profile and biological activity. Direct-injection electron ionization-mass spectrometry "fingerprinting" is useful for characterizing biological materials. We demonstrate the utility of direct-injection electron ionization-mass spectrometry for metabolic profiling using 100 different extracts of leaves from 20 blueberry cultivars collected at 5 time points from April to December 2008. A qualitative direct-injection electron ionization-mass spectrometry method was used to profile the major and/or minor constituents in the blueberry leaf extracts...
September 13, 2018: Planta Medica
Carmelo Puglia, Debora Santonocito, Teresa Musumeci, Venera Cardile, Adriana Carol Eleonora Graziano, Loredana Salerno, Giuseppina Raciti, Lucia Crascì, Anna Maria Panico, Giovanni Puglisi
Crocin and crocetin are two interesting constituents of saffron ( Crocus sativus ) that possess important biological activities. Their use as therapeutic agents is strongly compromised by a scarce stability, poor absorption, and low bioavailability. Therefore, to improve these unfavorable features, the aim of the present work has been to apply a nanotechnological approach based on the formulation of solid lipid nanoparticles containing crocin and crocetin. Solid lipid nanoparticles were formulated according to crocin and crocetin chemical properties, using a variation of the quasi-emulsion solvent diffusion method to formulate crocin-solid lipid nanoparticles, while crocetin-solid lipid nanoparticles were prepared following the solvent diffusion method...
September 11, 2018: Planta Medica
Sang-Uk Woo, Hay-Ran Jang, Young-Won Chin, Hyungshin Yim
Polo-like kinase 1, a mitotic Ser/Thr kinase, has emerged as a molecular target for the development of anticancer drugs. In this study, we found that polo-like kinase 1 activity was inhibited by 7- O -methylwogonin and related flavones, including baicalein, dihydrobaicalein, and viscidulin II, isolated from Scutellaria baicalensis . Although dihydrobaicalein exhibited the highest polo-like kinase 1 inhibitory activity among the four compounds, it also inhibited other kinases, such as vaccinia-related kinase 2 and polo-like kinase 2...
September 10, 2018: Planta Medica
Hyo Jeong Son, Young Jin Jang, Chang Hwa Jung, Jiyun Ahn, Tae Youl Ha
2,6-Dimethoxy-1,4-benzoquinone is a natural phytochemical present in fermented wheat germ. It has been reported to exhibit anti-inflammatory, antitumor, and antibacterial activities. However, the anti-adipogenic effects of 2,6-dimethoxy-1,4-benzoquinone and the mechanisms responsible have not previously been elucidated. Such findings may have ramifications for the treatment of obesity. 2,6-Dimethoxy-1,4-benzoquinone (5 and 7.5 µM) significantly reduced the expression of various adipogenic transcription factors, including peroxisome proliferator-activated receptor- γ and CCAAT/enhancer binding protein α as well as adipocyte protein 2 and fatty acid synthase...
September 10, 2018: Planta Medica
Zhiyong Lei, Zhijian Cao, Zaiwang Yang, Mingzhang Ao, Wenwen Jin, Longjiang Yu
Poor wound healing is a major and global threat to public health. Efforts have been made to better understand the underlying mechanisms and develop effective remedies, though the advancements that have been made are still limited. As there are no effective and generally applicable therapies available for skin injuries and fibrosis, it is urgent to develop new drugs and therapies that facilitate wound healing and effectively improve scars. In this study, GC-MS analysis was performed to identify the chemical composition of rosehip oil...
September 10, 2018: Planta Medica
Leila Mohtashami, Narjes Ghows, Zahra Tayarani-Najaran, Mehrdad Iranshahi
Galbanic acid is a natural sesquiterpene coumarin compound with different biological activities, particularly cytotoxicity against LNCaP (an androgen-dependent prostate cancer cell line). Galbanic acid induces apoptosis in LNCaP via down-regulation of androgen receptor. However, the poor water-solubility of galbanic acid limits further in vitro and in vivo studies. In this study we present the synthesis of galbanic acid-coated Fe3 O4 magnetic nanoparticles and their cytotoxicity evaluation on three prostate cancer cell lines, including PC3 (an androgen-independent cell line), LNCaP, and DU145 (an androgen-independent cell line)...
September 4, 2018: Planta Medica
Bharathi Avula, Ji-Yeong Bae, Vijayasankar Raman, Omer I Fantoukh, Yan-Hong Wang, Ahmed G Osman, Mei Wang, Zulfiqar Ali, Ikhlas A Khan
Fadogia agrestis is used in traditional African medicine as an analgesic and for anti-inflammatory and aphrodisiac activities. An ultra-high-performance liquid chromatography method was developed for the determination of 11 chemical constituents from roots and aerial parts of F. agrestis. The separation was achieved within 7 min by using C-18 column material and a water/acetonitrile mobile phase, both containing 0.1% formic acid gradient system with a temperature of 45 °C. The method was validated for linearity, repeatability, limits of detection, and limits of quantification...
August 31, 2018: Planta Medica
Tamam El-Elimat, Karem H Alzoubi, Mahmoud M AbuAlSamen, Zeinab Y Al Subeh, Tyler N Graf, Nicholas H Oberlies
Post-traumatic stress disorder (PTSD) is a debilitating psychopathological disease that is triggered by exposure to traumatic events. It is usually associated with substantial comorbidities, such as cognitive impairment, anxiety, and depression. Silymarin has been recently reported to exert neuroprotective activities against neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Herein, the beneficial effects of silymarin in ameliorating PTSD-like symptoms such as memory impairments, anxiety, and depression were evaluated using a single-prolonged stress (SPS) rat model of PTSD...
August 28, 2018: Planta Medica
Veronica Santana de Freitas-Blanco, Karin Maia Monteiro, Patrícia Rosa de Oliveira, Ellen Cristina Souza de Oliveira, Lucia Elaine de Oliveira Braga, João Ernesto de Carvalho, Rodney Alexandre Ferreira Rodrigues
Mucositis is one of the commonest side effects in cancer patients undergoing treatment with radiotherapy and/or chemotherapy, and it currently lacks appropriate and effective treatment. Acmella oleracea , a species of flowering herb from South America, contains spilanthol, an alkylamide that has several pharmacological properties, including anesthetic, analgesic, and anti-inflammatory activities. Therefore, the purpose of this work was to evaluate the effect of spilanthol in intestinal mucositis in Swiss mice induced by 5-fluorouracil (5-FU), an antineoplastic agent administered systemically for the treatment of many different cancers...
August 28, 2018: Planta Medica
Vilawan Payon, Chanaporn Kongsaden, Wannarasmi Ketchart, Apiwat Mutirangura, Piyanuch Wonganan
Cepharanthine (CEP), a medicinal product derived from Stephania cephalantha Hayata, possesses a potent cytotoxicity against several types of cancers. Recently, we have found that CEP could efficiently inhibit the growth of mutated p53 colon cancer cells, which are often resistant to commonly used chemotherapeutic agents. In this study, we evaluated the cytotoxic effect and the underlying mechanisms of CEP on both chemosensitive CaOV-3 and chemoresistant OVCAR-3 ovarian cancer cell lines. The present study demonstrated that CEP significantly inhibited the growth of CaOV-3 and OVCAR-3 cells in a time- and concentration-dependent manner...
August 24, 2018: Planta Medica
Nadezhda Dyrkheeva, Olga Luzina, Aleksandr Filimonov, Olga Zakharova, Ekaterina Ilina, Alexandra Zakharenko, Maxim Kuprushkin, Dmitry Nilov, Irina Gushchina, Vytas Švedas, Nariman Salakhutdinov, Olga Lavrik
Usnic acid, a lichen secondary metabolite produced by a whole number of lichens, has attracted the interest of researchers owing to its broad range of biological activity, including antiviral, antibiotic, anticancer properties, and it possessing a certain toxicity. The synthesis of new usnic acid derivatives and the investigation of their biological activity may lead to the discovery of compounds with better pharmacological and toxicity profiles. In this context, a series of new usnic acid derivatives comprising a terpenoid moiety were synthesized, and their ability to inhibit the catalytic activity of the human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 was investigated...
August 24, 2018: Planta Medica
Ulrike Grienke, Julia Zwirchmayr, Ursula Peintner, Ernst Urban, Martin Zehl, Michaela Schmidtke, Judith M Rollinger
In an in vitro screening for anti-influenza agents from European polypores, the fruit body extract of Gloeophyllum odoratum dose-dependently inhibited the cytopathic effect of the H3N2 influenza virus A/Hong Kong/68 (HK/68) in Madin Darby canine kidney cells with a 50% inhibitory concentration (IC50 ) of 15 µg/mL, a noncytotoxic concentration. After a chromatographic work-up, eight lanostane triterpenes (1: -8: ) were isolated and their structures were elucidated based on high-resolution electrospray ionization mass spectrometry analyses, and one- and two-dimensional nuclear magnetic resonance experiments...
August 21, 2018: Planta Medica
Hyun-Jae Jang, Eun-Jae Park, Seung-Jae Lee, Hyung-Jin Lim, Jin Ha Jo, Seung Woong Lee, Mun-Chual Rho
Three undescribed diarylheptanoids (3: -5: ) and six known curcuminoids (1, 2: , and 6: -9: ) were obtained from the ethyl acetate-soluble fraction of an ethanolic extract of Curcuma phaeocaulis . Their chemical structures and absolute configurations were elucidated by high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, circular dichroism spectroscopy, and the modified Mosher's method. Previous studies constructed Hep3B cells stably transfected with pSTAT3-Luc plasmid containing STAT3 binding site to discover STAT3 inhibitors from natural products...
August 10, 2018: Planta Medica
Boyi Fan, Baocheng Jiang, Sensen Yan, Bohui Xu, Huilian Huang, Guangtong Chen
In this study, the biocatalysis of 18 β -glycyrrhetinic acid by two strains of filamentous fungi, namely Rhizopus arrhizus AS 3.2893 and Circinella muscae AS 3.2695, was investigated. Scaled-up biotransformation reactions yielded 14 metabolites. Their structures were established based on extensive nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data analyses, and seven of them are new compounds. The two fungal strains exhibited distinct biocatalytic features. R. arrhizus could catalyze hydroxylation and carbonylation reactions, whereas C...
August 7, 2018: Planta Medica
Eman Shawky, Dina A Selim
Parallel to the growing global interest in alternative medical therapies, high measures of counterfeit pharmaceuticals enter the global market and, therefore, detection of such marketed products is essential. This article throws an illuminating spot on the adulteration of Cinnamomum verum ( Cinnamomum zeylanicum ) with Cinnamomum cassia and exhaustively extracted C. verum . A speedy and nondestructive near-infrared method in conjunction with the mathematical tools of chemometrics was used to distinguish between genuine cinnamon and its common adulterants...
August 1, 2018: Planta Medica
Iffat Parveen, Natascha Techen, Ikhlas A Khan
The species of the aromatic plant family Apiaceae are mainly used as spices and foods, but the family also includes medicinal and some poisonous plant species. Due to the similar chemical compounds or aroma and morphology, the poisonous species are often mistaken for the edible aromatic species. It is therefore imperative to correctly identify the species present at the initial raw stage samples to ensure product safety and efficacy. At the molecular level, plant species can be identified using DNA loci either from nuclear or plastid genome with easily available universal oligonucleotides, a technique called DNA barcoding...
July 31, 2018: Planta Medica
Barbara Tóth, Péter Hegyi, Tamás Lantos, Zsolt Szakács, Beáta Kerémi, Gábor Varga, Judit Tenk, Erika Pétervári, Márta Balaskó, Zoltán Rumbus, Zoltán Rakonczay, Emese Réka Bálint, Tivadar Kiss, Dezső Csupor
Herbal products, especially Hypericum perforatum extracts, have been widely used as first-line treatments for mild to moderate depression. Recently, several randomized, controlled clinical trials have been conducted to evaluate the efficacy of another plant, saffron ( Crocus sativus ), in mild to moderate depression. We have carried out a literature review of currently available published randomized, controlled clinical trials to give an up-to-date evaluation of the efficacy of saffron in mild to moderate depression, compared to placebo or routinely used antidepressants...
July 23, 2018: Planta Medica
Juan Carlos Gómez-Verjan, Nadia Alejandra Rivero-Segura, Edgar Estrella-Parra, Ruth Rincón-Heredia, Abraham Madariaga-Mazón, Edgar Flores-Soto, Mario González-Meljem, Marco Cerbón, Ricardo Reyes-Chilpa
Mammea-type coumarins are a particular type of secondary metabolites biosynthesized by the tropical rainforest tree Calophyllum Brasiliense , which is distributed from South America to Mexico. Particularly, mammea A/BA and A/BB (alone or as a mixture) possess biological properties such as cytotoxic and antitumoral activities, however, most of its molecular targets remain unknown. In this context, novel bioinformatic approaches, such as network pharmacology analysis, have been successfully used in herbal medicine to accelerate research in this field, and the support of experimental validations has been shown to be quite robust...
July 23, 2018: Planta Medica
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