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Bratislavské Lekárske Listy

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https://www.readbyqxmd.com/read/28664749/the-age-at-onset-in-multiple-sclerosis-is-associated-with-patient-s-prognosis
#1
D Cierny, J Lehotsky, S Hanysova, J Michalik, E Kantorova, S Sivak, E Kurca, D Dobrota, L Jesenska
BACKGROUND: The causes of the individual differences in the rate of disability progression in multiple sclerosis (MS) are still not completely clear. According to the long-term prognosis of MS patients, the search for new valuable prognostic markers of "benign" or "malign" MS is necessary. OBJECTIVES: Our aim was to assess the possible association of MS onset age with the disease disability progression rate in Slovak patients with MS. METHODS: By the unique pattern of evaluation of disability progression rate using Multiple Sclerosis Severity Score (MSSS), each of 270 MS patients was defined as slow-progressing, mid-rate progressing or rapidly progressing...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664748/impact-of-cleft-lip-and-or-palate-in-children-on-family-quality-of-life-before-and-after-reconstructive-surgery
#2
P Macho, M Bohac, J Fedeles, D Fekiacova, J Fedeles
BACKGROUND: The aim of the study was to evaluate the impact of cleft lip/palate children together with consequent treatment on quality of family life using standardized questionnaire. Different to previous studies the evaluation of quality of family life by questionnaire was realized twice in the same group of families (before the reconstructive surgery and several months after palatoplasty). METHODS: The study was conducted in 40 families divided in two groups: 20 families with children with cleft lip (CL), 20 families with children with cleft lip and palate (CLP)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664747/association-between-the-heart-rate-early-after-heart-transplantation-and-the-long-term-clinical-outcomes
#3
H Bedanova, P Fila, V Horvath, M Sebo, H Podrouzkova, M Orban, P Nemec
BACKGROUND: A strong correlation between a lower heart rate and survival has been demonstrated in various patient populations. The optimal heart rate for heart transplant patients is still unknown. The aim of our study was to evaluate the association between an early heart rate and survival after heart transplantation. MATERIAL AND METHODS: We retrospectively analysed a group of 330 patients, who underwent heart transplantation in our institution from 1994 to 2014 and complete datasets, including 24-hour heart rate monitoring one month after the heart transplantation...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664746/the-influence-of-food-restriction-on-the-small-bowel-does-intensive-short%C3%A2-term-food-restriction-lead-to-weight-loss
#4
P Makovicky, E Tumova, Z Volek, P Makovicky, J M Arnone, I Svecova, G Samasca
The objective of this study was to show morphological changes in the small intestine of Hyplus broiler rabbits following an eight‑day food restriction programme. The control group (C) received food ad libitum (ADL) for the duration of the experiment. Group R1 received 50g of food per day, and group R2 received 65g of food per day. After the food restriction diet had been completed, groups R1 and R2 were returned to ad libitum feeding. After food restriction and at the end of the experiment, the longest small bowel measurement was recorded in the C group...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664745/association-between-pentraxin-3-and-growth-differentiation-factor-15-in-adolescent-male-swimmers
#5
N Karakuyu, M Belviranli, N Okudan
BACKGROUND: The purpose of this study was to evaluate plasma pentraxin 3 (PTX3) and growth differentiation factor-15 (GDF-15) concentrations in adolescent male swimmers and compare any possible interactions with canonical biochemical parameters. METHODS: Twenty-six adolescent male swimmers and 29 gender- and age-matched sedentary controls participated in this study. Fasting blood samples were taken from the participants. Biochemical values and plasma PTX3 and GDF-15 levels were measured...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664744/therapeutic-effects-of-melatonin-and-quercetin-in-improvement-of-hepatic-steatosis-in-rats-through-supression-of-oxidative-damage
#6
M Esrefoglu, A Cetin, E Taslidere, H Elbe, B Ates, O E Tok, M S Aydin
BACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. METHODS: Rats were divided into 5 groups: Ethanol, Olive oil, CCl4, CCl4+Melatonin (CCl4+Mel), CCl4+Quercetin...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664743/mapk-pathway-regulated-the-cardiomyocyte-apoptosis-in-mice-with-post-infarction-heart-failure
#7
Q Zhang, L Lu, T Liang, M Liu, Z L Wang, P Y Zhang
BACKGROUND: To explore the role of the MAPK signaling pathway in the cardiomyocyte apoptosis of mice with post-infarction heart failure (HF). METHODS: Mice were divided into sham and myocardial infarction (MI) groups. Before surgery, the MI group was divided into SB203580 and PBS subgroups. A post-infarction HF model was established by ligating the left anterior descending coronary artery. Ventricular dilatation and cardiac function were observed by small animal echocardiography...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664742/delivery-of-hiv-1-nef-linked-to-heat-shock-protein-27-using-a-cationic-polymer-is-more-effective-than-cationic-lipid-in-mammalian-cells
#8
A Milani, A Bolhassani, M Heshmati
BACKGROUND: Different adjuvants and delivery systems have been used to enhance the potency of DNA vaccines against viral diseases. Among them, heat shock proteins (HSPs) are stress proteins that have multiple roles such as chaperon activity and anti-apoptotic and adjuvant properties. The goal of this study was to compare the expression of HIV-1 Nef, Hsp27 and Hsp27-Nef genes transfected in HEK-293T mammalian cells by TurboFect and Lipofectamine as a cationic polymer and lipid, respectively...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664741/risk-of-anal-incontinence-in-women-with-inflammatory-bowel-diseases-after-delivery
#9
J Kozeluhova, J Kotyza, K Balihar, M Krcma, M Cedikova, J Karbanova, V Kalis, E Janska, M Matejovic
AIM: The aim of our prospective study was to evaluate the development of postpartum anal incontinence in patients with inflammatory bowel disease (IBD) compared to healthy women. MATERIAL AND METHODS: Patients with IBD and healthy controls enrolled in the study from January 1st 2013 to November 30th 2016 and filled in the anal incontinence questionnaire in the beginning of pregnancy and after vaginal delivery. The results were statistically processed using suitable tests...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664740/the-impact-of-physiological-peripartal-stress-on-the-lifelong-health-of-newborn
#10
J Hederlingova, P Psenkova, J Zahumensky
In the last decades the exponential increase in frequency of Caesarean sections is being observed. At the same time, there is growing amount of epidemiologic data showing higher lifetime risk of incidence of several diseases in offspring who do not experience natural labour. These findings lead to investigation of mechanisms which are responsible for maladaptation of several organ systems. Authors of this article describe these mechanisms, focusing especially on epigenetic programming, production of microbiome and positive effect of peripartal stress on successful beginning of extrauterine life...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664739/neutrophil-to-lymphocyte-ratio-sixteen-year-long-history-since-publication-of-our-article-in-bratislava-medical-journal
#11
R Zahorec
No abstract text is available yet for this article.
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28664738/danger-of-very-high-hdl-levels
#12
E Ginter, I Kajaba
No abstract text is available yet for this article.
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516796/legionella-spp-in-dental-unit-waterlines
#13
E Sedlata Juraskova, H Sedlackova, J Janska, O Holy, I Lalova, I Matouskova
OBJECTIVE: To determine the current presence of Legionella spp. in the output water of dental unit waterlines (DUWLs) and examine its mitigation by disinfection at the Institute of Dentistry and Oral Sciences, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc. MATERIAL AND METHODS: The first stage of our survey involved collecting samples of DUWL output water from 50 dental chair units (DCUs), and 2 samples of the incoming potable water...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516795/a-comprehensive-guide-to-telocytes-and-their-great-potential-in-cardiovascular-system
#14
I Kucybala, P Janas, S Ciuk, W Cholopiak, W Klimek-Piotrowska, M K Holda
Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology - the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood flow...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516794/association-of-the-postoperative-white-blood-cells-wbc-count-in-peripheral-blood-after-radical-surgical-treatment-of-left-upper-lobe-non-small-cell-lung-cancer-nsclc-with-overall-survival-single-center-results
#15
M Benej, I Capov, J Skrickova, K Hejduk, A Pestal, J Wechsler, H Coupkova, V Hytych
INTRODUCTION: The individual patient prognosis after radical surgery for Non-small cell lung cancer (NSCLC) of left upper lobe remains still unclear. The purpose of this study is to evaluate the predictive value of elevated white blood cell count in peripheral blood as early indicator of postoperative NSCLC prognosis. METHODS: A retrospective statistical analysis was performed studying patients subject to radical treatment of left upper lobe NSCLC in period of five years with subsequent one to three-year monitoring of morbidity and mortality of the patient population...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516793/red-or-white-wine-consumption-effect-on-atherosclerosis-in-healthy-individuals-in-vino-veritas-study
#16
M Taborsky, P Ostadal, T Adam, O Moravec, V Gloger, A Schee, T Skala
AIMS: Consumption of wine has a protective effect on cardiovascular diseases. Data from prospective, long-term, head-to-head comparisons of effects of different drinks on markers of atherosclerosis have been insufficient. METHODS AND RESULTS: In Vino Veritas (IVV) study is long-term, prospective, multi-centre, randomized trial comparing effects of red and white wine on atherosclerosis. 157 healthy subjects were randomized to white or red wine consumption for one year...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516792/apoptosis-of-colon-cancer-cells-under-the-effect-of-geldanamycin-derivate
#17
F Kosova, Z Kasar, I Tuglu, F Ozdal Kurt, S Gok, Z Ari, T Imren
AIM: The apoptotic effect of geldanamycin derivative may be important for the colorectal cancer therapy. The mechanisms of apoptosis require understanding of the behavior of colon cancer cell line Colo-205 which mimics colon adenocarcinoma. Therefore, the effect of IC50 dose of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on the colon cancer cells in vitro was studied for its anti-apoptotic activity. METHOD: Apoptotic ratio of the Colo-205 cells was determined after 17-AAG application with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and apoptosis related genes...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516791/which-one-is-more-effective-for-the-treatment-of-rat-sepsis-model-thalidomide-or-etanercept
#18
N Ilhan, S Susam, H F Gul, R Bardas, N Ilhan
OBJECTIVE: We aimed to investigate the protective effect of selected treatment agents on liver injury in lipopolysaccharide (LPS)-induced rat sepsis model. BACKGROUND: The sepsis includes complex inflammatory responses between a microbial pathogen and the host immune system, and leads to organ failure and also death. METHODS: This study was performed with 29 male Wistar Albino rats. Rats were divided randomly into five groups: Sham group, LPS-treated sepsis group, LPS+thalidomide treated group, LPS+etanercept treated group and LPS+thalidomide+etanercept treated group, respectively...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516790/oxidative-effects-of-extremely-low-frequency-magnetic-field-and-radio-frequency-radiation-on-testes-tissues-of-diabetic-and-healthy-rats
#19
D Kuzay, C Ozer, B Sirav, A G Canseven, N Seyhan
With the development of technology, people are increasingly under the exposure of electromagnetic fields. Individuals with chronic diseases such as diabetes are now long-term exposed to Radio Frequency-RF radiation and extremely low frequency (ELF) magnetic fields (MFs). The purpose of this present study is to investigate oxidative effects and antioxidant parameters of ELF MFs and RF radiation on testis tissue in diabetic and healthy rats. Wistar male rats were divided into 10 groups. Intraperitoneal single dose STZ (65 mg/kg) dissolved in citrate buffer (0...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28516789/protective-effect-of-pravastatin-on-doxorubicin-induced-hepatotoxicity
#20
E Mansouri, A Jangaran, A Ashtari
OBJECTIVE: The present study was designed to investigate the possible protection of pravastatin against hepatic oxidative stress and dysfunctions induced by doxorubicin in rats. BACKGROUND: Statins have beneficial effects on oxidative stress and inflammation. METHODS: Male Sprague-Dawley rats were divided into four groups. Control group (received saline orally), Group 2 received pravastatin (20 mg/kg, i.p. for 15 days), Group 3 received single dose doxorubicin (15 mg/kg, i...
2017: Bratislavské Lekárske Listy
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