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Bratislavské Lekárske Listy

A M Lavezzi
No abstract text is available yet for this article.
2017: Bratislavské Lekárske Listy
M Nisari, S Yilmaz, R Eroz, T Ertekin, D Bircan, H Ulger
BACKGROUND: Curcumin is a polyphenol compound that has antioxidant, anticancer, anti-inflammatory, anti-hyperlipidemic and antimicrobial effects. Nucleolar-organizing regions are the sites of the gene on chromosomes. The present study was aimed to show the antitumoral effect of curcumin via AgNOR protein synthesis in Ehrlich's ascitic carcinoma (EAC) bearing mice. METHODS: Twenty three mice with EAC were randomly divided into 3 groups as positive control (n = 7), group 2 (n = 8) and 3 (n = 8) treated intraperitoneally with curcumin (25 mg/kg) and (50 mg/kg), respectively...
2017: Bratislavské Lekárske Listy
L Durackova, A Kristufkova, M Korbel
AIM: The aim of study was to compare some perinatal outcomes in mothers with type 1 diabetes mellitus (T1DM). MATERIAL AND METHODS: All patients with T1DM delivered at the 1st Department of Obstetrics and Gynaecology of Faculty of Medicine, Comenius University in Bratislava from January 1st 2009 to December 31th 2015 were included to the study. RESULTS: Out of 118 diabetic mothers, 46.6 % had vasculopathy and 53. 4 % were without microvascular complications...
2017: Bratislavské Lekárske Listy
E V Markelova, A L Romanchuk, E V Prosekova, V E Krasnikov, S N Beniova
The article considers the measured values of the level of MMP-1, MMP-8 and MMP-9, and of their tissue inhibitor Type I (TIMP-1) in the blood serum and mixed saliva samples of 78 patients (31 women - 36.2 %, 47 men - 63.8 %) suffering from odontogenic phlegmons in the oral and maxillofacial region. The study indicators were assessed through the enzyme-linked immunosorbent assay using diagnostic sets RandD Diagnostics Inc. (USA). An uncontrolled hyperactivation of metal proteinases as one of the components of the systemic inflammatory response in case of phlegmon-related complications in the oral and maxillofacial region, as well as development of the sepsis syndrome were studied and it was determined that it results in distortion of the processes of reparative hystogeny and compel us to employ new approaches to the treatment of this type of patients (Tab...
2017: Bratislavské Lekárske Listy
F Nowrouzi, M Azadbakht
OBJECTIVES: The effect of early postnatal indomethacin exposure on hepatocellular and developmental alterations in mice liver was investigated. METHODS: Pups received IP injections of 0, 25, 50 and 100 mg/kg indomethacin on P0, then killed at P21 and P60. RESULTS: Indomethacin significantly suppressed body weight at P21, but liver weight significantly decreased only in 25 mg/kg. In contrast, liver weight and liver to body weight ratio significantly increased with increasing dose of indomethacin by P60...
2017: Bratislavské Lekárske Listy
M Zhaleh, M Azadbakht, A Bidmeshki Pour
BACKGROUND: Staurospurine induces apoptosis in cell line. Bone Marrow Mesenchymal stem cells Soup is a promising tool for cell proliferation via a variety of secreted factors. In this study, we examined the effects of BMSCs Soup on Staurospurine induced-cell death in MCF-7 and AGS cells. METHODS: There were three Groups: Group I: no incubation with BM Soup; Group II: incubated with 24 h BM Soup; Group III: incubation with 48 h BM Soup. There were two treatments in each group...
2017: Bratislavské Lekárske Listy
O Benacka, J Benacka, P Blazicek, M Belansky, J Payer, Z Killinger, J Lietava
INTRODUCTION: Patients with rheumatoid arthritis (RA) have shorter life expectancy and their risk of cardiovascular death is more than 50 % higher than the rest of the population. Early myocardial dysfunction in RA patients may be detectable sooner using speckle‑tracking echocardiography. METHOD: Cross-sectional study enrolled 55 patients with RA (mean age 44.1 years) without known cardiovascular disease and 31 healthy controls. All subjects underwent a standard echocardiographic examination: indexed left ventricular mass, left ventricle ejection fraction, isovolumic contraction and relaxation times (IVCT and IVRT), mitral valve inflow curve (E/A), septal mitral annular motion (e'), and E/e' ratio as well as the speckle tracking assessment of left ventricle longitudinal, radial and circular strain and strain rate...
2017: Bratislavské Lekárske Listy
A Kurt, E E Kurt, R Kilic, C Oktem, F Tuncay, H R Erdem
OBJECTIVE: Aim of the study was to evaluate the choroidal thickness (CT) in patients with RA and detect the relation with disease activity and joint damage in patients with rheumatoid arthritisBACKGROUND: Rheumatoid arthritis (RA) is a systemic inflammatory disease associated with various extra-articular organ manifestations including ocular manifestationsMATERIALS AND METHODS: We included 59 eyes of 59 patients with RA and 59 eyes of 59 controls without RA in the study. Subfoveal and perifoveal CT were measured using enhanced depth imaging optic coherence tomography...
2017: Bratislavské Lekárske Listy
D Hirjak, V Machon, M Beno, B Galis, I Kupcova
Management of condylar head fractures (CHF) of the temporomandibular joint (TMJ) remains a source of controversy. Based on established literature, group of CHFs and conservative treatment connected with period of maxillomandibular fixation (MMF) increases the risk for TMJ ankylosis. This paper presents anatomical and functional results of surgical treatment of condylar head fractures in a group of 24 patients (29 joints). Fractures were diagnosed based on conventional radiographs and computed tomography (CT) scans...
2017: Bratislavské Lekárske Listy
C Anar, D Deniz, S Erol, O Batum, C Bicmen, U Yilmaz
AIM: The aim of the present study was to evaluate pre-treatment concentrations of leptin in patients with advanced lung cancer and to investigate possible associations between their levels and clinicopathological variables, response to therapy and overall survival. MATERIAL AND METHODS: There are 71 previously untreated patients with cytological or histological evidence of primary lung cancer who were admitted to the oncology department between November 2013 and August 2014...
2017: Bratislavské Lekárske Listy
M Pohanka, J Zakova, J Fusek
OBJECTIVES: In this work, we hypothesized whether galantamine could interact with the cholinergic anti-inflammatory pathway and modulate immunity this way. BACKGROUND: Galantamine is a drug used for the therapy of Alzheimer disease. The drug inhibits enzyme acetylcholinesterase in the central nervous system, which causes better availability of neurotransmitter acetylcholine. METHODS: In the experiment, we immunized BALB/c laboratory mice by keyhole limpet hemocyanin (KLH) in combination with galantamine in a dose 0...
2017: Bratislavské Lekárske Listy
M K Moridani, H Farhadi
OBJECTIVE: Epilepsy is a neurological disorder that causes seizures of many different types. Recent research has shown that epileptic seizures can be predicted by using the electrocardiogrami instead of the electroencephalogram. In this study, we used the heart rate variability that is generated by the fluctuating balance of sympathetic and parasympathetic nervous systems to predict epileptic seizures. METHODS: We studied 11 epilepsy patients to predict the seizure interval...
2017: Bratislavské Lekárske Listy
P Stanko, K Sobolikova, A A Manesh, R Foltan
No abstract text is available yet for this article.
2016: Bratislavské Lekárske Listy
C Iavazzo, G Vorgias, P E Iavazzo, I D Gkegkes
Dysgerminoma is the most common ovarian germ cell type ovarian tumour. Primarily, it presents in young women at reproductive age and thus, the preservation of fertility is considered to be fundamental when it is possible for these patients. In comparison to the past the restriction of the extent of the surgical procedure as well as the introduction of innovative chemotherapeutic regimens improved significantly both, the prognosis and the clinical outcomes of this rare neoplasia. As dysgerminomas are extremely radio- and chemosensitive, fertility sparing approach and less aggressive operations should be favoured...
2016: Bratislavské Lekárske Listy
A Kiraz, T Simsek, S Z Tekin, S Elmas, M Tekin, H Sahin, H B Altinisik, C Pala
OBJECTIVES AND BACKGROUND: Oleuropein is a phenolic compound of olive leaves. Enteric bacterial flora is very important for human health and diet is a directly affecting factor of enteric bacterial flora composition. In this study, it was hypothesized that oleuropein could reduce total aerobic bacterial count in rat caecal flora. METHODS: Twenty adult, male, Wistar albino rats were randomly divided into two groups. Group C (n=10) was fed with standard rat chow and water for 30 days...
2016: Bratislavské Lekárske Listy
Y Celik, B Resitoglu, M Komur, A Polat, A E Arslankoylu, C Okuyaz, S Erdogan, H Beydagi
BACKGROUND: The aim of this study was to determine if levetiracetam (LEV) is neuroprotective in neonatal rats with hypoxic-ischemic brain injury (HIBI). METHODS: The study included 7-d-old male Wistar rats that were randomly divided into the LEV400, LEV800, control, and sham groups. All the rats, except those in the sham group, underwent ligation of the carotid artery and were then kept in a hypoxic chamber containing 8% oxygen for 2 h. At the end of the hypoxic period the rats in the control group were administered saline solution 0...
2016: Bratislavské Lekárske Listy
A Sagkan-Ozturk, E A Demir, A Ozturk
OBJECTIVES: Intestinal motility is regulated by several neurotransmitters and neuropeptides including dopamine and acetylcholine as well as ghrelin. Metoclopramide and domperidone are long-standing treatment options for dysmotility, and erythromycin is suggested in selected patients. In the present study, we aimed to investigate the effects of mentioned prokinetics on ghrelin levels. METHODS: Serum ghrelin levels were estimated by using enzyme-linked immunoassay following a single administration of domperidone, metoclopramide, or erythromycin...
2016: Bratislavské Lekárske Listy
V Sivgin, A Kucuk, F M Comu, B Kosem, S Kartal, H C Turgut, H Arpaci, M E Aydin, D S Koc, A Ozer, M Arslan, M Alkan
BACKGROUND AND AIM: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross‑clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to increased tissue and organ injury. Lornoxicam and intravenous ibuprofen are becoming commonly used as non-steroidal anti-inflammatory drugs (NSAID) for postoperative analgesia. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg iv) and intravenous ibuprofen (30 mg/kg iv) on erythrocyte deformability in I/R model in rats...
2016: Bratislavské Lekárske Listy
M K A, N M Aziz, M A E, R A Rifaai
To assess the gastro-protective potential of the angiotensin (Ang-) (1-7) on the gastric secretion and ulceration induced by cold restraint stress (CRS) in adult male rats and the possible contribution of nitric oxide and prostaglandin E2. Rats were pylorically ligated and divided randomly into the following groups (8 rats each): control, cold-restraint stressed (CRS), stressed Ang-(1-7) treated, stressed L-NNA-Ang-(1-7) treated, stressed Indo-Ang-(1-7) treated groups. Our results revealed that Ang-(1-7) pre-treatment proved to be protective against development of ulcerative lesions in CRS model as evidenced by histological examination and the reduction of the ulcer index and this could be mediated through reduction of free and total acidity and pepsin concentration of gastric secretion with significantly decreased lipid peroxidation and increased the gastric protective nitric oxide and prostaglandin E2 levels...
2016: Bratislavské Lekárske Listy
M Krticka, D Ira, A Bilik, P Rotschein, J Svancara
BACKGROUND: Fasciotomy wounds can be a major contributor to length of stay for patients as well as a difficult reconstructive challenge. OBJECTIVES: To evaluate lower leg fasciotomy wound closure outcomes comparing treatment with combined dressing fabric (COM) and negative pressure wound therapy (NPWT) in combination with elastic dynamic ligature (EDL). METHODS: Retrospective study of 63 patients who underwent lower leg fasciotomy due to injury treated from January 2008 to December 2015 at the Department of Trauma Surgery, University Hospital Brno...
2016: Bratislavské Lekárske Listy
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