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Bratislavské Lekárske Listy

V Stvrtinova, K Mareschova, J Hasakova
No abstract text is available yet for this article.
2018: Bratislavské Lekárske Listy
E Ozgun, G Sayilan Ozgun, U Usta, S Eskiocak, N Sut, S Suer Gokmen
OBJECTIVES: We aimed to investigate the effect of lipoic acid in the prevention of myocardial infarction in diabetic rats. METHODS: Rats were divided into five groups as control, ISO, LA+ISO, STZ+ISO and STZ+LA+ISO. To induce diabetes, single dose of streptozotocin was injected to STZ+ISO and STZ+LA+ISO groups. Lipoic acid (10 mg/kg/day) was injected for 14 days to LA+ISO and STZ+LA+ISO groups. To induce myocardial infarction, isoproterenol was injected to ISO, LA+ISO, STZ+ISO and STZ+LA+ISO groups on the days 13 and 14 of lipoic acid treatment...
2018: Bratislavské Lekárske Listy
E Ghanbarpanah, M A Kohanpour, F Hosseini-Beheshti, L Yari, M Keshvari
BACKGROUND: FUS reduces the proliferator factors such as cyclin D1 and Cdk6, and increases Cdk and p27. Therefore, FUS prevents the growth of prostate cancer cells. METHODS: This review tried to summarize data about FUS gene expression in correlation with the degree of prostate cancer. To find the relevant studies, the search in PubMed, Science Direct, and Scopus were performed. RESULTS: Increasing the expression of FUS decreases and increases the rate of apoptosis of prostate cancer cells, respectively...
2018: Bratislavské Lekárske Listy
M Gunaydin, V Ozer, A Kalkan, S Ozer, A Sahin, M Sahin, S C Karahan, S Dogramaci, O Tatli, A Gunduz
OBJECTIVE: This preliminary study aims to examine a change in the blood levels of irisin in patients with acute pericarditis (AP) and acute myopericarditis (AMP) and examine the diagnostic value of the serum irisin level in AP and AMP. METHODS: 10 patients, who applied to the emergency service and cardiology clinic with chest pain and who were diagnosed with AP and 5 patients, who were diagnosed with AMP as a result of routine examinations, were included in the study...
2018: Bratislavské Lekárske Listy
M Ibrahimi, B Jamalzei, M E Akbari, R Ibrahimi, M Alaei, M Moossavi, M Mohammadoo-Khorasani
BACKGROUND: Breast cancer (BC) is one of the most common types of cancer and the second leading cause of cancer death among women. Epidemiological studies showed that BC is linked to genetic and environmental factors, and inheritance plays a key role in the pathobiology of this disease. Interleukin 4 (IL-4) is a key differentiation cytokine and is produced by Th2 and activates Th2 development. Hence the current study aimed to assess the possible association between interleukin 4 (IL-4) VNTR polymorphism, and BC susceptibility in a sample of Iranian population...
2018: Bratislavské Lekárske Listy
M Valkova, I Lazurova, D Petrasova, M Frankovicova, I Dravecka
INTRODUCTION: Peripheral arterial disease (PAD) is a common condition due to atherosclerosis with high prevalence in population over 55 years. Although its pathophysiology is well recognized, the role of inflammatory markers is still not fully known. OBJECTIVES: The aim of the study was to assess the relation of C-reactive protein (CRP), tumor necrosis factors-alpha (TNF-alpha) and interleukin-6 (IL-6) to ankle-brachial index (ABI) and metabolic variables in patients with PAD...
2018: Bratislavské Lekárske Listy
A Ozer, F M Comu, A Kucuk, Y Kilic, M Alkan, L Oktar, M Arslan, L Ozturk
OBJECTIVE: In this study we aimed to evaluate the effect of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischaemia-reperfusion (IR) injury in streptozotocin-induced diabetic rats. MATERIAL AND METHODS: Thirty Wistar albino rats were equally divided into 5 groups (n = 6); randomized control group (Group C), diabetes control group (Group DC), DIR group (Group DIR), DIR group with thymoquinone 25‒1 intraperitoneally (Group DIRT) and Group DIR with dexmedetomidine 100 µg...
2018: Bratislavské Lekárske Listy
M Karademir, M A Sonmez, R Akcilar, E Kocak, A Yay, O Eser
OBJECTIVE: This study aimed to investigate the therapeutic effect of ozone in combination with insulin on cranial and spinal neuropathy in rats with diabetes mellitus (DM). MATERIALS AND METHODS: Sixty adult male Sprague Dawley rats were randomly divided into the following six groups (n = 10): control (C), ozone (O), diabetic (D), ozone-treated diabetic (DO), insulin-treated diabetic (DI), and ozone, insulin-treated diabetic (DOI). DM was induced by a single intraperitoneal (ip) streptozotocin injection (60 mg/kg), followed by 3 IU (ip) insulin administration for 60 days...
2018: Bratislavské Lekárske Listy
B Bostan, F Gevrek, O Balta, K Aytekin, M Asci, M B Eren, Y E Kuyucu
OBJECTIVES: In this study, we sought to investigate the effect of different amounts of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs), obtained by different BMSCs, on the healing of avascular zone meniscal defects. BACKGROUND: Treating avascular zone meniscal injuries has gained popularity. BMSCs contribute to the healing of avascular zone meniscal defects. The amount of BMSCs derived from different bone marrow stimulation techniques (BMSTs) varies, which could affect the therapeutic efficacy of this treatment...
2018: Bratislavské Lekárske Listy
O Kutlay
BACKGROUND: Apelin is an endogenous adipocytokine that plays an important role in the regulation of cardiovascular function. Apelin-36 is a member of apelin family. However cardiac reports related to apelin-36 are very rare. The purpose of this study is to investigate the impact of apelin-36 on hemodynamic variables of the isolated rat hearts. METHODS: Twenty-eight rats were equally divided into four groups: control, apelin-36 at the following concentrations: 1 nM, 10 nM and 100 nM...
2018: Bratislavské Lekárske Listy
K Dikmen, H Bostanci, H Gobut, A Yavuz, M Alper, M Kerem
PURPOSE:   Adiponectin is a protein stemming from adipose tissue and having strong anti-inflammatory properties. We aimed to assess the damage diminishing effects of recombinant adiponectin  (rAD) through NF-kB in the experimental acute pancreatitis  (AP) model. MATERIALS AND METHODS:   Acute pancreatitis was created by applying 50 µg/kg dose of intraperitoneal cerulean. The rats were randomised and divided into 3 groups as control, AP and rAD groups. Moreover, the rats in each group were divided into two sub-groups as 24th and 48th hour subgroups...
2018: Bratislavské Lekárske Listy
S Bahmanpour, F Karimi, A Soleimani, M Kamali, M R Namavar
BACKGROUND: Carbamazepine (CBZ) is used for the treatment of epileptic seizures. This study was designed to evaluate the effect of Interferon-gamma on the fetal heart and kidney histopathological changes of CBZ-treated pregnant mice. METHODS: Twenty pregnant mice were divided into four groups. The control group received distilled water. The second group received 240 mg/kg of CBZ by gastric gavage. The third group received intraperitoneal injection (IP) of IFN-γ...
2018: Bratislavské Lekárske Listy
S Sarica, I Altun
OBJECTIVE: To investigate the histopathological and biochemical effects of topical and systemic administrations of erythropoietin (EPO) on crush and transection type peripheral nerve injuries in an experimental rat model. METHODS: 128 male Wistar-Albino rats were allocated to 8 groups according to the route of administration of EPO (local/systemic) and type of peripheral nerve injury (crush/transection). groups were compared with respect to histopathological examination and number of axons as well as levels of IL-1β, IL-6, and IL-10...
2018: Bratislavské Lekárske Listy
B Durmus Ozen, M Uyanoglu
BACKGROUND: Carvacrol is a component in the essential oil of Lamiaceae family. Beside its antihepatotoxic and hepatoprotective properties it is known to be a contribution to liver regeneration. OBJECTIVES: This study aimed to investigate the effects of carvacrol in rat liver regeneration after 70 % partial hepatectomy (PHx) through interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinases (MAPK) pathways...
2018: Bratislavské Lekárske Listy
E D Eker, B Arslan, M Yildirim, A Akar, N Aras
OBJECTIVE: Radiofrequency electromagnetic fields (RF-EMF) may induce DNA damage and oxidative stress in human lens epithelial cells (LECs). We aimed to investigate the expression levels of heat shock protein 27 (Hsp27), p38 mitogen-activated protein kinase (p38MAPK), epidermal growth factor receptor (EGFR) and caspase-3 gene expression levels in rat eye that was exposed to 1800 MHz RF-EMF. METHODS: Thirty-seven female Wistar albino rats were divided into three groups...
2018: Bratislavské Lekárske Listy
S N Narayanan, S T Lukose, G Arun, N Mohapatra, J Pamala, P L Concessao, R Jetti, V Kedage, K Nalini, P Gopalakrishna Bhat
In the present study, the effect of 900 MHz radiation exposure on blood biochemical and reproductive parameters was evaluated in adolescent rats. Male albino Wistar rats (8-10 weeks of age) were exposed to 900 MHz radiation (1hr/day, power density - 146.60 µW/cm2) from a mobile phone for 28 days. On 29th day the animals were euthanized and malondialdehyde (MDA), total antioxidants (TA) levels and Glutathione-S transferase (GST) activity were studied in the blood. Reproductive parameters such as total sperm count, percentage of non-motile sperms, and sperm morphology were determined...
2018: Bratislavské Lekárske Listy
J Fillo, J Breza, M Ondrusova, J Luha, D Ondrus, J Dubravicky, J Breza, P Labas, M Levcikova
INTRODUCTION: In this article, the authors evaluate subjective and objective results of long testosterone replacement therapy (TRT) and possible risk. METHODS: In a single center study, the authors treated 69 men with testosterone deficiency syndrome (TDS). The average age was 57.84 years and the follow-up period was 94.62 months. All men had at beginning a complete urological and internal examination. All the men were treated with three-month i.m. injections of 1000 mg testosterone undecanoate...
2018: Bratislavské Lekárske Listy
O Senormanci, S Karakas Celik, E Valipour, V Dogan, G Senormanci
OBJECTIVES: We used the whole-exome sequencing to evaluate several genes suspected of being involved in the pathogenesis of schizophrenia. METHODS: The study sample was composed of two families. In the first family, two siblings had schizophrenia, and the parents were healthy. In the second family, two siblings had schizophrenia, while the other sibling and the parents did not. RESULTS: Indels were detected in some genes, including SPON1, GRIA3, SMAD5, PCLO, KMT2C, SRD5A2, SEMA3B, NCOR2, GPHB5, FAM174B, CLTCL1, and TMEM216...
2018: Bratislavské Lekárske Listy
A Karatas, E Canakci, O Bektas, T Bayrak, A Bayrak, A Altınbas, E Turkmen
INTRODUCTION AND OBJECTIVE: IMA and MPO are elevated in serum in case of end-stage renal disease. Epicardial fat tissue thickness has been considered an indicator for cardiovascular diseases recently. The present study was aimed to examine the relationship of epicardial fat tissue thickness (EFTT) with IMA and MPO levels in patients with CKD. MATERIALS AND METHODS: Predialysis CKD patients admitted to the Nephrology outpatient clinic, patients on haemodialysis and healthy volunteers were included, 111 patients were in the study...
2018: Bratislavské Lekárske Listy
P Bacik, P Poliacikova, G Kaliska
INTRODUCTION: We aimed to identify predictive factors for pacemaker requirement and determine the rate of pacemaker dependency in a single centre patient group. METHODS AND REULTS: Out of 116 patients, who underwent transcatheter aortic valve implantation at our institution. Absence of atrial fibrillation at time of procedure, pulmonary hypertension, obesity and severity of aortic valve stenosis were predictive for the need of permanent pacemaker implantation after transcatheter aortic valve implantation...
2018: Bratislavské Lekárske Listy
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