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Scandinavian Journal of Gastroenterology

Shanyu Qin, Yongru Liu, Hongjian Ning, Lin Tao, Wei Luo, Donghong Lu, Zuojie Luo, Yingfen Qin, Jia Zhou, Junqiang Chen, Haixing Jiang
BACKGROUND AND AIMS: EUS-guided ablation with ethanol has been used to treat insulinoma since 2006 as a minimally invasive alternative for those who are unwilling or unsuitable for surgeries. However, pancreatic fistula, pancreatitis and other adverse effects were found after the procedure in these patients. Herein, we aimed to find a novel feasible injection. METHODS: Seven patients with different chief complaints were diagnosed with insulinoma by symptoms, lab results and pathology results from EUS fine needle aspiration...
November 16, 2017: Scandinavian Journal of Gastroenterology
Linn Såve Nymo, Lars Aabakken, Kristoffer Lassen
INTRODUCTION: An unwanted socioeconomic health gap is observed in Western countries with easily accessible, government-financed health care systems. Survival rates from several malignancies differ between socioeconomic clusters and the disparities remain after adjusting for major co-morbidities and health related behavior. The possibility of biased conduct among health care workers has been proposed as a contributing factor, but evidence is sparse. METHODS: A blinded, randomized online questionnaire survey was conducted among specialists in gastroenterology in Norway...
November 16, 2017: Scandinavian Journal of Gastroenterology
Negin Kashani, Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
November 16, 2017: Scandinavian Journal of Gastroenterology
Palle Bager, Usha Chauhan, Kay Greveson, Susanna Jäghult, Liesbeth Moortgat, Karen Kemp
OBJECTIVE: Advice lines for patients with inflammatory bowel diseases (IBD) have been introduced internationally. However, only a few publications have described the advice line service and evaluated the efficiency of it with many results presented as conference posters. A systematic synthesis of evidence is needed and the aim of this article was to systematically review the evidence of IBD advice lines. MATERIALS AND METHODS: A broad systematic literature search was performed to identify relevant studies addressing the effect of advice lines...
November 13, 2017: Scandinavian Journal of Gastroenterology
Rasmus Waehrens, Xinjun Li, Jan Sundquist, Kristina Sundquist, Bengt Zöller
OBJECTIVE: Studies of the importance of perinatal factors for the development of irritable bowel syndrome (IBS) are sparse. We conducted a large national cohort study to examine perinatal and familial risk factors for IBS. MATERIAL AND METHODS: A national cohort of 1,963,685 persons who were born in Sweden in 1973-1992 (identified from the Swedish Birth Registry) were followed up for adult (18 years and older) IBS incidence in the Swedish Patient Register through 2010 (maximum age 38 years)...
November 10, 2017: Scandinavian Journal of Gastroenterology
Liang Zheng, Xiangping Wang, Qin Tao, Shuhui Liang, Biaoluo Wang, Hui Luo, Rongchun Zhang, Liyue Zheng, Shengye Yang, Jie Chen, Yanglin Pan, Xuegang Guo
OBJECTIVE: To identify possible risk factors associated with post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in biliary stricture (BS), common bile duct stone (CBDS) and unselected patients. MATERIALS AND METHODS: Consecutive ERCP patients with native papilla from January 2010 to December 2014 in Xijing Hospital were eligible. Patient-related and procedure-related parameters were collected retrospectively. The primary outcome was PEP...
November 9, 2017: Scandinavian Journal of Gastroenterology
Chander Shekhar, Ben Maher, Colm Forde, Brinder Singh Mahon
BACKGROUND AND AIM: Endoscopic ultrasound-guided drainage is a minimally invasive first-line modality for the drainage of pancreatic fluid collection (PFC) resulting in a shorter hospital stay and less morbidity compared with surgical cystogastrostomy. Our aim is to evaluate potential differences in the outcomes of endoscopic ultrasound (EUS) guided transmural drainage (EUS-TD) drainage of pancreatic pseudocyst (PP) and walled-off necrosis (WON). METHOD: We retrospectively reviewed 100 consecutive EUS-guided drainages of PFC utilising EUS reports; clinical notes and imaging with follow-up (FU) to 12 months...
November 9, 2017: Scandinavian Journal of Gastroenterology
Emilie Glavind, Niels Kristian Aagaard, Henning Gronbaek, Nikolaj Worm Orntoft, Hendrik Vilstrup, Karen Louise Thomsen
OBJECTIVES: Alcoholic hepatitis (AH) markedly decreases the urea synthesis capacity. We aimed to investigate the time course of this compromised essential liver function in patients with AH and its relation to treatment and survival. MATERIALS AND METHODS: Thirty patients with AH were included in a prospective cohort study. We measured the substrate-independent urea synthesis capacity, i.e., the functional hepatic nitrogen clearance (FHNC), in the patients at study entry and again at three months (survivors/available: n = 17)...
November 7, 2017: Scandinavian Journal of Gastroenterology
Trine Larsen, Trygve Hausken, Synne Otteraaen Ystad, Nils Hovdenak, Bernd Mueller, Gülen Arslan Lied
RATIONALE: Patients with radiation-induced enteropathy (RE) after cancer treatment show similar symptoms as patients with irritable bowel syndrome (IBS). The low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet (LFD) is a widespread management strategy for IBS. We aimed to investigate if there may be a positive effect of LFD on symptoms and health-related quality of life (HRQOL) in patients with RE. METHODS: In an open non-controlled pilot study, 11 patients (all female) with RE-related IBS symptoms were recruited largely based on own initiative...
November 7, 2017: Scandinavian Journal of Gastroenterology
Line Aabel Stokbro, Ove B Schaffalitzky de Muckadell, Stig Borbjerg Laursen
OBJECTIVE: Upper gastrointestinal bleeding (UGIB) is a frequent medical emergency and several scoring systems are developed to help risk-stratify patients. We aimed to investigate if elevated arterial lactate (AL) was associated with 30-day mortality, need for hospital-based intervention, or rebleeding. Furthermore, we compared the performance of AL with existing scoring systems and examined if incorporation of AL could improve their predictive ability. MATERIALS AND METHODS: Retrospective cohort study of 331 consecutive patients admitted with UGIB during a one-year period...
November 6, 2017: Scandinavian Journal of Gastroenterology
Alan R Zinsmeister, Linda M Herrick, Yuri A Saito Loftus, Cathy D Schleck, Nicholas J Talley
OBJECTIVE: Attempts to categorize distinct functional gastrointestinal disorders based on reported symptoms continue but symptoms frequently overlap. The study objective was to use latent class analysis (LCA) which accommodates both continuous and discrete manifest variables to determine mutually exclusive subgroup assignments of a population-based sample using gastrointestinal symptom and patient data. MATERIALS AND METHODS: A validated bowel disease questionnaire and somatic symptom questionnaire were mailed to an age and gender stratified randomly selected community sample...
November 6, 2017: Scandinavian Journal of Gastroenterology
Line Lund Kårhus, Nina Gunnes, Ketil Størdal, Inger Johanne Bakken, German Tapia, Lars C Stene, Siri E Håberg, Karl Mårild
OBJECTIVES: Influenza has been linked to autoimmune conditions, but its relationship to subsequent celiac disease (CD) is unknown. Our primary aim was to determine the risk of CD after influenza. A secondary analysis examined the risk of CD following pandemic influenza vaccination. METHODS: This nationwide register-based cohort study included 2,637,746 Norwegians (born between 1967-2013) followed during 2006-2014 with information on influenza diagnosed in primary or non-primary care, pandemic vaccination (Pandemrix), and subsequent CD...
October 27, 2017: Scandinavian Journal of Gastroenterology
Jia Luo, Lu-Ning Xu, Sheng-Jun Zhang, Yi-Gui Jiang, De-Xiang Zhuo, Lian-Hui Wu, Xiang Jiang, Yue Huang
OBJECTIVES: Using microarray analysis, we previously showed that many lncRNAs are differentially expressed in colorectal cancer (CRC) tissues compared with normal tissues, suggesting that lncRNAs may be involved the initiation and progression of CRC. In this study, we investigated the expression and function of lncRNA-RP11-317J10.2 in human CRC tissues and cell lines. METHODS: LncRNA-RP11-317J10.2 expression level was analyzed in 52 colon cancer and cell lines. We used shRNA to knock-down the expression of RP11-317J10...
October 26, 2017: Scandinavian Journal of Gastroenterology
Janne Fuglsang Hansen, Mette Juul Nielsen, Kristina Nyström, Diana Julie Leeming, Martin Lagging, Gunnar Norkrans, Peer Brehm Christensen, Morten Karsdal
OBJECTIVE: Detecting significant fibrosis and cirrhosis remains important in treatment and follow-up of patients with chronic hepatitis C Infection (CHC). The aim of this study was to assess the ability of PRO-C3 to identify significant fibrosis (Ishak score ≥3) and cirrhosis (Ishak score ≥5) both as a single test and as a part of algorithms. MATERIALS AND METHODS: PRO-C3 was assessed in baseline samples from the NORDynamIC trial. 270 patients were stratified into groups according to baseline biopsy...
October 25, 2017: Scandinavian Journal of Gastroenterology
Suguru Fukahori, Minoru Yagi, Shinji Ishii, Kimio Asagiri, Nobuyuki Saikusa, Naoki Hashizume, Motomu Yoshida, Daisuke Masui, Naruki Higashidate, Saki Sakamoto, Hirotomo Nakahara, Yoshiaki Tanaka
BACKGROUND: The present study aimed to evaluate the characteristics associated with a number of reflux episodes (NoRE) of 70 by comparing the clinical and multichannel intraluminal impedance pH measurements (pH/MII) and pH index (pHI) in neurologically impaired (NI) children. PATIENTS AND METHODS: NI children (1-16 years of age) in whom pH/MII had been measured for GERD study were enrolled in this study. All children were divided into NoRE >70 or ≤70 and pHI >4...
October 25, 2017: Scandinavian Journal of Gastroenterology
Cordula Barth, Silke Neusser, Janine Biermann, Jürgen Wasem, Thomas Berg, Johannes Wiegand, Ingmar Wolffram, David Petroff, Pamela Aidelsburger, Alexandra Grünbauer, Anja Neumann
OBJECTIVES: Systematic screening for chronic hepatitis B and C does not yet exist in Germany. Therefore, the implementation of a screening approach within a preventive medical examination performed by primary care physicians ('Check-Up 35+') was evaluated in a recent prospective multicenter study. The present analysis estimates the financial consequences for the statutory health insurance by budget impact analysis. MATERIALS AND METHODS: A Markov cohort model was developed consisting of 21 health states...
October 24, 2017: Scandinavian Journal of Gastroenterology
Antonella Gallo, Carla Vallone, Ludovico Sabatelli, Giulio Ventura, Marcello Covino, Giovanni Cammarota, Antonio Gasbarrini, Raffaele Landolfi, Massimo Montalto
BACKGROUND: Clostridium difficile infection (CDI) is characterized by a relevant intestinal neutrophil infiltrate. So far, role of fecal calprotectin in CDI, has been investigated only in few studies, mainly focused on diagnosis of the disease. AIM: By a longitudinal design, we assess fecal calprotectin concentrations (FCCs) in subjects with CDI, evaluating the correlation between fecal marker and response to therapy. METHODS: Clinical (diarrhea scoring) and laboratory (FCCs and leucocytes count) evaluation was performed in 56 subjects with CDI at time of diagnosis (T0) and after a week from starting of therapy (T1)...
October 24, 2017: Scandinavian Journal of Gastroenterology
Dong Hyo Noh, Kyu Choi, Seonhye Gu, Juhee Cho, Kee-Taek Jang, Young Sik Woo, Kyu Taek Lee, Jong Kyun Lee, Kwang Hyuck Lee
BACKGROUND: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is effective for tissue diagnosis of pancreatic mass. To improve diagnostic yield and drawbacks, 22-gauge (G) core biopsy (FNB) needle has been developed. This study aims to compare 22G FNA and FNB needles for EUS-guided sampling of suspected pancreatic cancer. METHODS: This is a randomized controlled crossover trial. A total of 60 patients with suspected unresectable pancreatic cancer referred for EUS-guided sampling were randomly assigned to two groups...
October 24, 2017: Scandinavian Journal of Gastroenterology
Sara B Jonsdottir, Gunnar Juliusson, Jon Ö Kristinsson, Johann P Hreinsson, Jon G Jonasson, Einar S Björnsson
OBJECTIVE: Limited data exist on the changes in the epidemiology of pancreatic cancer and outcomes over the last decades in population-based cohorts. We aimed to compare the incidence of pancreatic cancer, diagnostic, treatment and survival among patients diagnosed over the period 1986-2009. MATERIALS AND METHODS: A retrospective, nationwide, population-based study. All patients diagnosed with pancreatic cancer in Iceland in two periods, 1986-1997 (P1) and 1998-2009 (P2) were identified through the Icelandic Cancer Registry and relevant clinical information obtained from medical records...
October 23, 2017: Scandinavian Journal of Gastroenterology
Marie Louise Sunde, Petr Ricanek, Tom Øresland, Jørgen Jahnsen, Nazir Naimy, Arne Engebreth Færden
BACKGROUND: Variability in functional outcome after ileal-pouch anal anastomosis (IPAA) is to a large extent unexplained. The aim of this study was to perform multiple physiological and biochemical tests including an endoscopic examination with histology on IPAA patients with well and poorly functioning pouches to determine factors, or combinations thereof, contributing to functional outcome. METHODS: All patients with ulcerative colitis undergoing restorative proctocolectomy between 2000 and 2013 (N = 108) were interviewed using a pouch functioning score...
October 18, 2017: Scandinavian Journal of Gastroenterology
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