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Scandinavian Journal of Gastroenterology

Eva Lesén, Åse Björstad, Ingela Björholt, Tom Marlow, Entela Bollano, Marion Feuilly, Florence Marteau, Staffan Welin, Anna-Karin Elf, Viktor Johanson
OBJECTIVES: To quantify healthcare resource use (HRU) and costs in relation to carcinoid syndrome (CS) and carcinoid heart disease (CHD) in a real-world setting, and to provide perspective on treatment patterns. MATERIALS AND METHODS: Patient data and HRU were collected retrospectively from three Swedish healthcare registers. Adult patients diagnosed with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) grade 1 or 2 and CS who purchased somatostatin analogs (SSAs), and experienced controlled (defined by SSAs use) and uncontrolled (defined by SSAs dose escalation) CS for ≥8 months during the study period were included...
November 19, 2018: Scandinavian Journal of Gastroenterology
Jens F Rehfeld, Filip K Knop, Ali Asmar, Sten Madsbad, Jens J Holst, Meena Asmar
OBJECTIVE: Recent randomized and controlled trials of drugs derived from the gut hormone glucagon-like peptide-1 (GLP-1) show that the most frequent adverse symptoms are gastrointestinal, including gallbladder-related side effects such as cholithiasis and cholecystitis. Since the gut hormone cholecystokinin (CCK) stimulates bile secretion and regulates gallbladder motility and emptying, we examined the effect of GLP-1 on the secretion of CCK in normal subjects and patients with type 1 diabetes mellitus...
November 19, 2018: Scandinavian Journal of Gastroenterology
Kalle Landerholm, Christopher Wood, Alexander Bloemendaal, Nicolas Buchs, Bruce George, Richard Guy
OBJECTIVES: Acute severe colitis requires surgery in around 30% of the cases. Total colectomy with ileostomy is the standard procedure with distinct advantages to a laparoscopic approach. Less agreement exists regarding the formation or configuration of the retained rectal stump and its short-term and long-term management. In this review, aspects of management of the rectal remnant, including perioperative considerations, potential complications, medical treatment, surveillance and implications for proctectomy and reconstructive surgery are explored...
November 18, 2018: Scandinavian Journal of Gastroenterology
Rahul Kalla, Ray Boyapati, Simen Vatn, Gonzalo Hijos, Benjamin Crooks, Gregory Thomas Moore, Veronica Hall, George Lipscomb, Fernando Gomollón, Jørgen Jahnsen, Salil Singh
INTRODUCTION: Despite its success, there appears to be practical issues with Faecal Calprotectin (FC) testing in Inflammatory Bowel Diseases (IBD), including sample collection, delivery and processing delays. Patients' perception and barriers to FC testing are yet to be explored in clinical practice. METHOD: A prospective patient survey was undertaken at IBD units in UK, Europe and Australia. A 9-point patient-based questionnaire was completed in clinic and included demographics, previous FC testing and FC sample difficulty rating score...
November 18, 2018: Scandinavian Journal of Gastroenterology
Li Cao, Yun Wang, Jinlin Wang, Qiaozhen Guo, Qian Chen, Xiaoli Wu, Shou-Jiang Tang, Bin Cheng
OBJECTIVES: Histopathological examination is pivotal in diagnosing autoimmune pancreatitis (AIP). The usefulness of EUS-guided fine needle aspiration (EUS-FNA) in diagnosing AIP remains controversial worldwide. The authors conducted this study to evaluate the efficacy of EUS-FNA for AIP diagnosis using a 22-gauge needle. METHODS: Between January 2013 and May 2017, 37 patients had imaging studies suggestive of AIP at Tongji Hospital, and 27 patients of them were enrolled in this study...
November 13, 2018: Scandinavian Journal of Gastroenterology
Hege Kileng, Midori Kjellin, Dario Akaberi, Assar Bergfors, Ann-Sofi Duberg, Lars Wesslén, Astrid Danielsson, Magnhild Gangsøy Kristiansen, Tore Gutteberg, Rasmus Goll, Anders Lannergård, Johan Lennerstrand
OBJECTIVES: Resistance-associated substitutions (RASs) may impair treatment response to direct-acting antivirals (DAA) in hepatitis C virus (HCV) treatment. We investigated the effects of baseline NS3-RASs (Q80K and R155K) and clinically relevant NS5A-RASs in patients with HCV genotype (GT) 1a infection on treatment outcome, with or without resistance-based DAA-treatment. This multi-center study was carried out between 2014 and 2016. PATIENTS/METHODS: Treatment in the intervention group (n = 92) was tailored to baseline resistance...
November 5, 2018: Scandinavian Journal of Gastroenterology
Antti Siiki, Yrjö Vaalavuo, Anne Antila, Mika Ukkonen, Irina Rinta-Kiikka, Juhani Sand, Johanna Laukkarinen
BACKGROUND: The treatment of post-cholecystectomy bile leak is endoscopic retrograde cholangiography (ERC) with plastic stent (PS) insertion combined with external drainage. Self-expanding biodegradable biliary stents (BDBS) have only recently become available. AIM: The aim was to compare success rate, adverse events and costs of BDBS with PS in the treatment of post-cholecystectomy cystic duct leak Materials and methods: Patients recruited prospectively for treatment with BDBS during the period 2014-2017 were compared to a control group treated with PS in a non-randomized setting...
November 5, 2018: Scandinavian Journal of Gastroenterology
Stuart K Roberts, Alessia Gazzola, John Lubel, Paul Gow, Sally Bell, Amanda Nicoll, Anouk Dev, Michael A Fink, Siddharth Sood, Virginia Knight, Thai Hong, Eldho Paul, Gauri Mishra, Ammar Majeed, William Kemp
OBJECTIVE: The objectives of our study were firstly to characterize the treatment stage migration phenomenon in early (Barcelona Clinic Liver Cancer [BCLC]-0/A) stage hepatocellular carcinoma (HCC) by comparing the efficacy of curative therapies with trans-arterial chemoembolization [TACE] and secondly, determining baseline and on-treatment predictors of survival. METHODS: All patients within BCLC-0/A stage from six tertiary hospitals who received curative therapy with either resection, transplantation, or ablation or TACE as first-line treatment were included in the analyses...
November 5, 2018: Scandinavian Journal of Gastroenterology
B Bunganič, M Laclav, T Dvořáková, O Bradáč, E Traboulsi, Š Suchánek, P Frič, M Zavoral
OBJECTIVES: The main objective is to compare the accuracy of EUS and CEH EUS for the diagnosis of pancreatic cancer (PC). The secondary objective is to evaluate the accuracy of EUS FNA and to determine to what extent EUS and CEH EUS findings are affected by endosonographer subjectivity. METHODS: A prospective single-centre study was conducted in patients with pancreatic lesions detected on CT. The patients were examined by EUS, CEH EUS and EUS FNA. The obtained results were compared with the final diagnosis that was based on cytology and further clinical findings and on histopathological findings from subjects who underwent surgery...
November 5, 2018: Scandinavian Journal of Gastroenterology
Alberto Aiolfi, Davide Ferrari, Carlo Galdino Riva, Francesco Toti, Gianluca Bonitta, Luigi Bonavina
OBJECTIVE: Esophageal Foreign Body (FB) impaction represents a major challenge for healthcare providers. Aim of this systematic review was to analyse the current literature evidence on prevalence, presentation, treatment, and outcomes of impacted esophageal FB. MATERIALS AND METHODS: Literature search was conducted between 2000 and 30th June 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. RESULTS: Sixty-one studies matched the inclusion criteria...
November 5, 2018: Scandinavian Journal of Gastroenterology
Michael Dubow, Philip D Tatman, Raj J Shah
OBJECTIVES: Evaluation of indeterminate biliary strictures remains challenging due to limited sensitivity of endoscopic tissue sampling. Biliary probe-based confocal laser endomicroscopy (pCLE) has shown promise to detect and exclude neoplasia. However, knowledge of whether individual inflammatory criteria are more prevalent in neoplasia compared to benign strictures is limited. The objective of this work is to improve diagnosis of neoplastic and inflammatory conditions using pCLE. MATERIALS AND METHODS: The charts of all patients who underwent pCLE at a single referral center between 2009 and 2015 were reviewed...
November 5, 2018: Scandinavian Journal of Gastroenterology
Hendrike E Bolkenstein, Bryan Jm van de Wall, Esther Cj Consten, Job van der Palen, Ivo Amj Broeders, Werner A Draaisma
OBJECTIVES: Most diverticulitis patients (80%) who are referred to secondary care have uncomplicated diverticulitis (UD) which is a self-limiting disease and can be treated at home. The aim of this study is to develop a diagnostic model that can safely rule out complicated diverticulitis (CD) based on clinical and laboratory parameters to reduce unnecessary referrals. METHODS: A retrospective cross-sectional study was performed including all patients who presented at the emergency department with CT-proven diverticulitis...
November 5, 2018: Scandinavian Journal of Gastroenterology
Marcus Kantowski, Alain M Schoepfer, Utz Settmacher, Andreas Stallmach, Carsten Schmidt
INTRODUCTION: Rebleeding or emergency surgery in failed endoscopic therapy of peptic ulcer bleeding are associated with high rates of morbidity and mortality. The clinical benefit of an endoscopic Doppler (ED) examination prior to endoscopic injection therapy was evaluated in high risk ulcer patients for rebleeding episode. Standard injection therapy (non-Doppler (ND)) was compared with targeted injection therapy after examination of the supplying vessel in the ulcer base by the ED. MATERIALS AND METHODS: Sixty patients with peptic ulcer bleeding (Forrest Ia-IIa; Rockall score of 5 or higher) were included in the study...
November 5, 2018: Scandinavian Journal of Gastroenterology
Nada Boutrid, Hakim Rahmoune, Mounira Amrane
No abstract text is available yet for this article.
October 24, 2018: Scandinavian Journal of Gastroenterology
Stefan Haraldsson, Stine Roug, Camilla Nøjgaard, Srdan Novovic, Lise Lotte Gluud, Erik Feldager, Palle Nordblad Schmidt
INTRODUCTION: Previous studies suggest that fragmentation of pancreatic duct stones (PDS) using extracorporeal shock wave lithotripsy (ESWL) is associated with pain relief. However, the treatment may not be effective in certain subgroups. AIM: To evaluate predictors of pain relief after ESWL in patients with chronic pancreatitis and PDS. METHODS: Retrospective study including patients with chronic pancreatitis undergoing ESWL for painful PDS...
October 24, 2018: Scandinavian Journal of Gastroenterology
Ravi Thiruvengadam, Sushrut S Thiruvengadam
Of 166 consecutive diagnostic colonoscopies performed on persons aged forty and under (excluding those at an increased risk of colon neoplasms) by a single gastroenterologist in community practice with an Adenoma Detection Rate (ADR) approaching 70% in average-risk screening colons in persons over fifty, 34 had incidentally detected colon adenomas and 38 had serrated polyps. We suggest routine tabulation of incidentally detected polyps in young people to better understand colon neoplasm biology and plan prevention strategies...
October 24, 2018: Scandinavian Journal of Gastroenterology
C R Lamers, W G N Mares, D J Bac
Black esophagus or acute esophageal necrosis (AEN) is a rare medical disorder which is characterized by a diffuse circumferential black esophageal mucosa. The majority of patients present with signs of upper gastrointestinal bleeding. Diagnosis is made based on esophagogastroduodenoscopy. Treatment consists of intravenous fluids, proton pomp inhibitors and additional therapies to treat the underlying illness. In this article we present five cases of patients with AEN and briefly review the literature of AEN...
October 24, 2018: Scandinavian Journal of Gastroenterology
Rune R Tronstad, Tatiana Polushina, Hans-Richard Brattbakk, Christine Stansberg, Hilde Løland von Volkmann, Kurt Hanevik, Eva Ellinghaus, Silje Fjellgård Jørgensen, Kari Merete Ersland, Khanh D-C Pham, Odd Helge Gilja, Nils Hovdenak, Trygve Hausken, Morten H Vatn, Andre Franke, Per Morten Knappskog, Stephanie Le Hellard, Tom Hemming Karlsen, Torunn Fiskerstrand
OBJECTIVE: Activating mutations in the GUCY2C gene, which encodes the epithelial receptor guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the intestinal lumen. Patients with familial GUCY2C diarrhea syndrome (FGDS) are predisposed to inflammatory bowel disease (IBD). We investigated whether genes in the guanylate cyclase C pathway are enriched for association with IBD and reversely whether genetic or transcriptional changes associated with IBD are found in FGDS patients...
October 24, 2018: Scandinavian Journal of Gastroenterology
Bochao Zhao, Jingting Zhang, Di Mei, Jiale Zhang, Rui Luo, Huimian Xu, Baojun Huang
BACKGROUND: Although various risk classification systems for GISTs have been proposed, the optimum one remains uncertain. In the present study, we compared the prognostic stratification of different risk classification systems for GIST patients. METHODS: We reviewed those patients who were pathologically diagnosed with GISTs in the SEER database between 2009 and 2014. All patients were classified into different risk groups according to the NIH criteria, AFIP criteria and AJCC staging system, respectively...
October 24, 2018: Scandinavian Journal of Gastroenterology
A Thorisson, M Nikberg, K Andreasson, K Smedh, A Chabok
OBJECTIVES: The aim of this study was to describe patient characteristics and results of non-operative management for patients presenting with computed tomography (CT) verified perforated diverticulitis with extraluminal or free air. METHODS: All patients treated for diverticulitis (ICD-10: K-57) during 2010-2014 were identified and medical records were reviewed. Re-evaluations of CT examinations for all patients with complicated disease according to medical records were performed...
October 24, 2018: Scandinavian Journal of Gastroenterology
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