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Scandinavian Journal of Gastroenterology

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https://www.readbyqxmd.com/read/30010450/the-risk-of-developing-a-mismatch-repair-deficient-colorectal-cancer-after-undergoing-cholecystectomy
#1
Matthias Orn Halldorsson, Michael Hauptmann, Petur Snaebjornsson, Kristín Huld Haraldsdóttir, Thor Aspelund, Elias Freyr Gudmundsson, Vilmundur Gudnason, Jon Gunnlaugur Jonasson, Sigurdis Haraldsdottir
OBJECTIVES: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the risk of a dMMR CRC by comparing CCY incidence in patients with dMMR CRC and proficient MMR (pMMR) CRC to unaffected controls. MATERIALS AND METHODS: All patients diagnosed with CRC in Iceland from 2000 to 2009 (n = 1171) were included...
July 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/30010449/endoscopic-predictive-factors-associated-with-local-recurrence-after-gastric-endoscopic-submucosal-dissection
#2
Hyeong Seok Nam, Cheol Woong Choi, Su Jin Kim, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Dae Gon Ryu
OBJECTIVE: Endoscopic submucosal dissection (ESD) has been accepted as the treatment of choice for gastric epithelial neoplasia. Endoscopic characteristics of the primary lesion and post-ESD scars may be informative to predict the possibility of local recurrence. METHODS: Between November 2008 and July 2015, a retrospective study was conducted in a single-tertiary referral hospital. Consecutive patients who underwent ESD for early gastric cancer (EGC) or high-grade dysplasia were analyzed to evaluate the incidence of local recurrence and associated endoscopic characteristics...
July 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29987967/success-and-safety-of-high-infliximab-trough-levels-in-inflammatory-bowel-disease
#3
David Drobne, Tina Kurent, Sasa Golob, Polona Svegl, Polona Rajar, Sara Terzic, Matic Kozelj, Gregor Novak, Natasa Smrekar, Samo Plut, Nejc Sever, Luka Strnisa, Jurij Hanzel, Jernej Brecelj, Darja Urlep, Josko Osredkar, Matjaz Homan, Rok Orel, Borut Stabuc, Ivan Ferkolj, Alojz Smid
OBJECTIVE: A prospective trial suggests target infliximab trough levels of 3-7 μg/mL, yet data on additional therapeutic benefits and safety of higher trough levels are scarce. AIM: To explore whether high infliximab trough levels (≥7 μg/mL) are more effective and still safe. MATERIAL AND METHODS: In this cohort study of 183 patients (109 Crohn's disease and 74 ulcerative colitis) on infliximab maintenance treatment at a tertiary referral center we correlated fecal calprotectin and C-reactive protein to trough levels (426 samples) at different time points during treatment...
July 10, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29987961/rapid-and-persistent-decline-in-soluble-cd163-with-successful-direct-acting-antiviral-therapy-and-associations-with-chronic-hepatitis-c-histology
#4
Tea Lund Laursen, Cecilie Brøckner Siggard, Konstantin Kazankov, Thomas Damgaard Sandahl, Holger Jon Møller, Adrian Ong, Mark W Douglas, Jacob George, Britta Tarp, Lena Hagelskjaer Kristensen, Alex Lund Laursen, Akira Hiramatsu, Takashi Nakahara, Kazuaki Chayama, Henning Grønbaek
BACKGROUND AND AIM: Soluble CD 163 (sCD163) is released from activated liver macrophages in chronic viral hepatitis C (HCV) and serum levels reflect liver disease severity. The impact of direct-acting antiviral (DAA)-therapy on sCD163-levels and the ability of sCD163 to predict the presence of liver fibrosis remain unclear. In a combined observational and prospective study, we aimed to investigate changes in sCD163 with DAA-treatment, to investigate associations between sCD163 and histopathological activity and fibrosis and to validate the sCD163-based fibrosis score in HCV-patients...
July 10, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29987951/outcome-of-continued-infliximab-therapy-in-crohn-s-disease-patients-with-response-but-without-remission-after-one-year-of-infliximab-a-retrospective-cohort-study
#5
Sine Buhl, Märta Kristina Borghede, Jørn Brynskov, Casper Steenholdt, Maria Rasmussen, Mark Andrew Ainsworth
BACKGROUND: Optimal management of Crohn's disease patients having responded to infliximab but without achieving remission is not well defined. The present study examined if these patients benefit from continued long-term infliximab maintenance therapy. METHOD: Retrospective cohort study including all patients treated with infliximab for 1 year until the end of 2017 who have had a response but not reached remission on infliximab. Clinical outcomes were defined by the physicians' global evaluation, supported by clinical indices and objective markers of disease activity...
July 10, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29979091/is-there-a-role-for-routine-colonoscopy-in-the-follow-up-after-acute-appendicitis
#6
Eirik Sylthe Pedersen, Tore Stornes, Lars Cato Rekstad, Tom Christian Martinsen
BACKGROUND: Mechanical obstruction of the appendiceal lumen is proposed as a possible factor in the pathogenesis of acute appendicitis. Hence, patients over the age of 40 are often referred to a follow-up colonoscopy after admission for acute appendicitis. The use of CT scans question whether routine colonoscopy still has a place in follow-up for these patients. METHODS: All patients aged over 40 years with confirmed acute appendicitis admitted to St. Olav's Hospital in the period from 2010 to 2015 were included in this retrospective study...
July 6, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29979088/predictors-for-choledocholithiasis-in-patients-undergoing-endoscopic-ultrasound
#7
Rutger Quispel, Nora D L Hallensleben, Lydi M W J van Driel, Marco J Bruno
No abstract text is available yet for this article.
July 6, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29978732/quality-of-life-performance-status-and-work-capacity-after-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#8
Bonna Leerhøy, Daniel Mønsted Shabanzadeh, Andreas Nordholm-Carstensen, Lars Nannestad Jørgensen
OBJECTIVES: This study evaluated the long-term consequences of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) on health related quality of life (HRQOL), performance status, and work capacity. MATERIALS AND METHODS: A follow-up study with prospective outcome measurements on patients with previous PEP and matched controls from a Danish cohort of 772 patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). HRQOL was evaluated by the short form 36 health surveys, performance status by the Zubrod score, and work capacity by employment status...
July 6, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29972646/corrigendum
#9
(no author information available yet)
No abstract text is available yet for this article.
July 4, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29969048/how-ameliorate-the-adherence-in-patients-with-inflammatory-bowel-disease
#10
Davide Giuseppe Ribaldone, Marta Vernero, Marco Astegiano, Rinaldo Pellicano
No abstract text is available yet for this article.
July 3, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29968483/the-sensitivity-of-fecal-calprotectin-in-predicting-deep-remission-in-ulcerative-colitis
#11
Katrine Carlsen, Lene Buhl Riis, Henriette Elsberg, Louise Maagaard, Tine Thorkilgaard, Sveinung Wergeland Sørbye, Christian Jakobsen, Vibeke Wewer, Jon Florholmen, Rasmus Goll, Pia Munkholm
BACKGROUND: Mucosal healing is proposed as treat-to-target in ulcerative colitis (UC), even though the definition of mucosal healing remains contested as it has been suggested to be assessed by either endoscopy, histology or both. However, all definitions require an endoscopic evaluation of the mucosa. As endoscopies are invasive and uncomfortable to the patient we aimed to calibrate noninvasive predictors of mucosal inflammatory status defined by both endoscopy and histology. METHODS: UC patients (n = 106) undergoing a sigmoid-/colonoscopy were prospectively included...
July 3, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29966460/arterial-calcium-stimulation-with-hepatic-venous-sampling-predicts-the-localization-and-size-of-the-insulinoma-as-well-as-postoperative-weight-loss
#12
Maja Baretić, Dražen Perkov, Petra Vuica, Antonia Jakovčević, Mato Škegro
No abstract text is available yet for this article.
July 3, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29966446/the-use-of-single-balloon-enteroscopy-in-crohn-s-disease-and-its-impact-on-clinical-outcome
#13
Grainne Holleran, Giorgio Valerii, Annalisa Tortora, Franco Scaldaferri, Silvia Conti, Arianna Amato, Antonio Gasbarrini, Guido Costamagna, Maria Elena Riccioni
OBJECTIVES: Single balloon enteroscopy (SBE) is an effective and safe modality for the diagnosis and therapeutic intervention of small bowel disorders. Its use in patients with Crohn's disease (CD) and particularly its effect on management changes in CD have not yet been determined. MATERIALS AND METHODS: We performed a retrospective review of the endoscopic and clinical data available on a cohort of patients with small bowel CD who had undergone SBE to determine the diagnostic and therapeutic yield of the procedure and the initial and longer-term impact it had on clinical management...
July 2, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29966445/persistent-mixed-cryoglobulinemia-after-successful-antiviral-treatment-of-chronic-hepatitis-c-virus-infection-what-s-the-next
#14
M L Zubkin, D T Abdurakhmanov, O I Sagalova, I G Bakulin, M V Maevskaya, V T Ivashkin
No abstract text is available yet for this article.
July 2, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29909701/prevalence-and-outcome-of-post-transfusion-hepatitis-c-acquired-at-different-ages-and-detected-in-look-back-screening
#15
Charlotta Millbourn, Afrodite Psaros Einberg, Gudrun Lindh, Ingegerd Hökeberg, Björn Fischler, Karin Lindahl
OBJECTIVES: The prevalence of hepatitis C virus (HCV) infection in Sweden is estimated to 0.5%. Before 1992, blood transfusion posed a risk of HCV transmission. The primary aim of this study was to estimate anti-HCV prevalence in Stockholm County among individuals receiving blood transfusions 1965-1991. The secondary aim was to study the effect of age at transfusion on the development of liver disease and treatment outcome. MATERIALS AND METHODS: This is a retrospective analysis of individuals found to be anti-HCV tested positive in Stockholm County during a national screening campaign in Sweden 2008-2010...
June 18, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29911438/different-scoring-systems-to-predict-6-week-mortality-in-cirrhosis-patients-with-acute-variceal-bleeding-a-retrospective-analysis-of-202-patients
#16
Fang Wang, Shu Cui, Fengmei Wang, Fenghui Li, Fei Tang, Xu Zhang, Yanying Gao, Hongmin Lv
OBJECTIVE: Determine the optimal scoring system for evaluation of 6-week bleeding-related mortality in liver cirrhosis patients with acute variceal bleeding (AVB). Prediction effects of six scoring systems, AIMS65 score, Glasgow-Blatchford (GBS) score, full Rockall (FRS) score, the model for end-stage liver disease (MELD), the MELD-Na model and the Child-Turcotte-Pugh (CTP) score were analyzed in this study. METHODS: A total of 202 liver cirrhosis patients with AVB were enrolled between 1 January 2014, and 31 December 2014...
June 17, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29911457/transient-elevation-of-anti-transglutaminase-and-anti-endomysium-antibodies-in-giardia-infection
#17
Kurt Hanevik, Elisabeth Wik, Nina Langeland, Trygve Hausken
Markers of celiac disease (CeD) may be elevated in various conditions of intestinal inflammation or autoimmune disease. Recent reports argue that intestinal infection may induce development of CeD in susceptible individuals. Serum anti-tissue transglutaminase (tTG) and anti-endomysium antibodies (EMA) have been proposed in previous reports to be helpful in differentiating between giardiasis and CeD. In this report, we describe eight cases with elevated CeD serological markers and pathological duodenal histology during, or shortly after, Giardia infection...
June 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29911441/occurrence-of-gastric-cancer-in-patients-with-atrophic-gastritis-during-long-term-follow-up
#18
Liming Zhang, Yulan Liu, Peng You, Guijian Feng
BACKGROUND: Additional data on the incidence of gastric neoplasia in the Chinese atrophic gastritis (AG) population during long-term follow-up are needed and the influence of the endoscopic surveillance interval on gastric neoplasia occurrence remains unknown. AIMS: Retrospectively investigated the occurrence of gastric cancer (GC) and precancerous lesions in AG patients during long-term follow-up and assessed risk factors, such as the endoscopic surveillance interval for the development of gastric neoplasia...
June 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29909694/crucial-genes-of-inflammatory-bowel-diseases-explored-by-gene-expression-profiling-analysis
#19
Dehong Xie, Yudong Zhang, Hao Qu
OBJECTIVES: This study aimed to uncover new potential genes associated with the inflammatory bowel diseases (IBDs). MATERIALS AND METHODS: The datasets GSE36807 and GSE9686 were obtained from Gene Expression Omnibus (GEO). Totally, 24 Crohn's disease (CD) samples, 20 ulcerative colitis (UC) samples and 15 healthy controls in the two datasets were used for our analysis. The differentially expressed genes (DEGs) were identified by limma package. Then, co-expression network was constructed by weighted gene correlation network analysis (WGCNA) package, and co-expression network modules were obtained via clustering method...
June 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29909690/children-with-untreated-coeliac-disease-have-sub-clinical-cardiac-dysfunction-a-longitudinal-observational-analysis
#20
Rishi Bolia, Anshu Srivastava, Aditya Kapoor, Surender Kumar Yachha, Ujjal Poddar
INTRODUCTION: We assessed cardiac function (CF) in celiac disease (CD) patients and the effect of gluten-free diet (GFD) on CF. METHODS: Prospective evaluation of CF using conventional and tissue doppler echocardiography in 50 CD patients (age 4.2 ± 1.1 years) at diagnosis and after a year of GFD (group 1), 100 CD children (group 2; 47 compliant and 53 non-compliant) in follow-up and 25 healthy controls. RESULTS: Untreated CD (n = 50) children had larger left ventricle end diastolic dimension (35...
June 16, 2018: Scandinavian Journal of Gastroenterology
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