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Scandinavian Journal of Gastroenterology

Jürgen Stein, Andreas Walper, Wolfgang Klemm, Karima Farrag, Ayşegül Aksan, Axel Dignass
AIMS: Iron deficiency anaemia (IDA) is common in patients with inflammatory bowel disease (IBD), who are often treated with intravenous iron. This observational study aimed to investigate the effectiveness and safety of iron isomaltoside in routine practical care of IDA in IBD patients. METHODS: The study included 197 IBD patients designated for treatment with iron isomaltoside. Treatment was administered according to routine practice. Data were recorded at baseline and after approximately 4, 8, and 16 weeks...
September 17, 2018: Scandinavian Journal of Gastroenterology
Jianmei Pan, Xiaohua Zhang, Yongjun Shi, Qingshan Pei
OBJECTIVE: There are no guidelines or consensus on the optimal treatment measures for small rectal neuroendocrine tumors (NETs) at present. This meta-analysis was conducted to compare the efficacy and safety of endoscopic mucosal resection (EMR) with suction and endoscopic submucosal dissection (ESD) for the small rectal NETs. METHODS: The literature searches were conducted using Pubmed and Embase databases, and then a meta-analysis was performed. The primary outcome was complete resection rate, and the secondary outcomes were complication rate, procedure time, and recurrence rate...
September 7, 2018: Scandinavian Journal of Gastroenterology
Friedemann Erchinger, Anne Kristine N Øvre, Marita Malene Aarseth, Trond Engjom, Ingeborg Brønstad, Georg Dimcevski, Oddrun Anita Gudbrandsen, Erling Tjora
BACKGROUND: Chronic pancreatitis (CP) can lead to severe pancreatic exocrine insufficiency (PEI). Pancreatic enzyme replacement therapy (PERT) is well established, but knowledge of the physiological response to increasing doses on fecal fat- and energy loss is scarce. METHODS: We included 10 patients with CP and established PEI and 12 healthy controls for a prospective interventional study. Subjects received no PERT in the first week followed by four weeks PERT incrementally increasing doses every week...
September 7, 2018: Scandinavian Journal of Gastroenterology
Jose M Huguet, Marisa Iborra, Marta Maia Bosca-Watts, Nuria Maroto, Rafael Gil, Xavier Cortes, David Hervás, Jose M Paredes
INTRODUCTION: The fastest growing segment of our population is that of people above 70 years of age. Elderly patients with IBD exhibit several specific problems. Our objective was to evaluate the clinical course, the side effects of the treatments and the need for surgery of elderly patients, regardless of the age of onset. MATERIALS AND METHODS: This was a cross-sectional study wherein retrospective data were collected from multiple centers from seven hospitals within the Valencia metropolitan area...
September 6, 2018: Scandinavian Journal of Gastroenterology
Laura Rindom Krogsgaard, Anne Line Engsbro, Peter Bytzer
OBJECTIVES: Use of antibiotics affects the composition of the gut microbiome. The microbiome is thought to play a role in development of irritable bowel syndrome (IBS), but antibiotics as a possible risk factor for IBS has not been clarified. We aimed to explore if antibiotics is a risk factor for IBS by investigating use of antibiotics and development of IBS in a cohort from the Danish background population. MATERIALS AND METHODS: An internet-based web panel representative of the Danish background population was invited to participate in a survey regarding the epidemiology of IBS in 2010, 2011 and 2013...
September 6, 2018: Scandinavian Journal of Gastroenterology
Min Liu, Mingju Hao
BACKGROUND: Autoimmune pancreatitis (AIP) is defined as a unique form of chronic pancreatitis characterized by clinical presentation with obstructive jaundice, a dense lymphoplasmacytic infiltrate and fibrosis histologically, and a dramatic response to steroids therapeutically. The possible role of IgG4 in driving the pathology of AIP is a controversial subject that has not been addressed satisfactorily.  Objective: The purpose of this review is to discuss the unique biology of IgG4 that are important for its role and the clinical applications for serologic detection...
September 2, 2018: Scandinavian Journal of Gastroenterology
Johanna Haapamäki, Erjastiina Heikkinen, Taina Sipponen, Risto P Roine, Perttu Arkkila
BACKGROUND: Inflammatory bowel disease (IBD) has a substantial impact on patients health-related quality of life (HRQoL). In this study, we examined the impact of adaptation courses on HRQoL, psychological well-being, depression and number of sick-leave days of IBD patients. METHODS: The study recruited 142 IBD patients attending an adaptation course of 5-12 days. The courses were specially designed for IBD patients and included multidisciplinary information about IBD, peer support, group activities and encouragement for adequate physical exercise...
September 2, 2018: Scandinavian Journal of Gastroenterology
Kwangwoo Nam, Jeong Eun Shin, Sung Eun Kim, Gwang Ho Baik, Sang Hyeon Choi, Ju Yup Lee, Kyung Sik Park, Young-Eun Joo, Dae-Seong Myung, Hyeon Ju Kim, Hyun Joo Song, Suck Chei Choi, Hyun Jin Kim, Hyun Young Kim, Nayoung Kim
OBJECTIVES: The prevalence of upper gastrointestinal disease is expected to change following advances in socioeconomic status and improved hygiene in Korea. The aim of this study was to investigate the recent trends in upper gastrointestinal diseases based on endoscopic findings and Helicobacter pylori (H. pylori) seroprevalence in subjects undergoing health check-up at tertiary centers in Korea. METHODS: A multicenter cross-sectional study was conducted at nine healthcare centers between September 2016 and June 2017...
August 31, 2018: Scandinavian Journal of Gastroenterology
Malin Sternby Eilard, Erik Holmberg, Peter Naredi, Gunnar Söderdahl, Magnus Rizell
OBJECTIVES: Liver transplantation in hepatocellular cancer (HCC) is curative only for a selection of patients. Commonly used criteria are mostly based on tumor size and number. However, patients within criteria do have tumor recurrences after transplantation and patients outside criteria are excluded even though some could benefit from transplantation. The tumor marker alpha fetoprotein (AFP) is associated with poor outcome and has already been reported to improve selection. We investigated the hypothesis that AFP level combined with traditional selection criteria could ameliorate the selection accuracy for liver transplantation in HCC...
August 31, 2018: Scandinavian Journal of Gastroenterology
Hui Li, Yi Gong, Ying Xie, Qian Sun, Yan Li
OBJECTIVE: To investigate the protective effects of Clostridium butyricum on the epithelial barrier in dextran sodium sulfate (DSS)-induced colitis. METHODS: Eight-week-old BALB/c mice were divided into a healthy control group and DSS-induced groups, including negative control (normal saline), 5-aminosalicylic acid (5-ASA), C. butyricum group, and 5-ASA + C. butyricum groups. Colitis was induced by 5% DSS ad libitum for 7 d. We assessed the disease activity index (DAI), histological grading, and ultrastructural changes by transmission electron microscopy...
August 24, 2018: Scandinavian Journal of Gastroenterology
Arnar B Ingason, Asgeir Theodors, Arnar S Agustsson, Adalsteinn Arnarson
OBJECTIVES: Gastric lipomas are rare adipose tumors that constitute less than 1% of gastric tumors. While lipomas generally do not need removal unless symptomatic, endoscopic resection has been proposed as safe for gastric lipomas smaller than 2 cm. Yet, there is no consensus on the optimal treatment method for larger lipomas. We report a case of a giant 7-cm gastric lipoma successfully removed by endoscopic submucosal dissection (ESD) and systematically review the literature for gastric lipomas removed by ESD...
August 23, 2018: Scandinavian Journal of Gastroenterology
Chan Hyung Lee, Hyuk Yoon, Yoon Jin Choi, Eun Sun Jang, Jaihwan Kim, Cheol Min Shin, Young Soo Park, Jin-Hyeok Hwang, Jin-Wook Kim, Sook-Hayng Jeong, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
BACKGROUND AND AIMS: Performing an endoscopy out of hours confer significant burdens on limited health-care resources. However, not all on-call endoscopies lead to therapeutic interventions. The purpose of the present study was to analyze predictive factors for performing therapeutic intervention in patients with suspected gastrointestinal bleeding. METHODS: We reviewed and analyzed electronic medical records regarding on-call endoscopy that were prospectively collected for quality control...
August 22, 2018: Scandinavian Journal of Gastroenterology
Xiaoqian Jing, Haoxuan Wu, Xi Cheng, Xianze Chen, Yaqi Zhang, Minmin Shi, Tao Zhang, Xiongjun Wang, Ren Zhao
OBJECTIVES: Colorectal cancer (CRC), one of the most aggressive gastrointestinal malignancies, is a frequently diagnosed life-threatening cancer worldwide. Most CRC patients have poor prognosis mainly because of frequent metastasis and recurrence. Thus, it is crucial to find out some new biomarkers and to show deeper insights into the mechanisms of CRC. MLLT10, Myeloid/lymphoid or mixed-lineage leukemia translocated to 10, also known as AF10, a recurrent MLL partner. In this study, we found that MLLT10 promotes CRC tumor invasion and metastasis both in vitro and in vivo...
August 13, 2018: Scandinavian Journal of Gastroenterology
Satoshi Shinozaki, Hiroyuki Osawa, Yasutoshi Kobayashi, Hirotsugu Sakamoto, Yoshikazu Hayashi, Yoshimasa Miura, Alan Kawarai Lefor, Hironori Yamamoto
OBJECTIVE: The novel potassium-competitive acid blocker, vonoprazan, provides rapid and effective acid suppression. The aim of this study is to evaluate the long-term outcomes of patients with symptomatic gastroesophageal reflux disease (GERD) treated with vonoprazan. METHODS: This retrospective cohort study included 55 patients with symptomatic GERD treated with vonoprazan who have been followed for more than one year. The effectiveness of vonoprazan on gastrointestinal symptoms was evaluated using the Izumo scale, a self-reported questionnaire reflecting quality of life related to various abdominal symptoms...
July 28, 2018: Scandinavian Journal of Gastroenterology
Krista Vitikainen, Johanna Haapamäki, Martti Färkkilä, Veli-Jukka Anttila, Perttu Arkkila
OBJECTIVE: Characterization of predisposing factors for Clostridium difficile infection recurrence (rCDI) and outcome in inflammatory bowel disease (IBD) patients. METHODS: Clinical characteristics of 167 inflammatory bowel disease patients with Clostridium difficile infection (IBD-CDI cohort) treated in Helsinki University Central Hospital were gathered. Medical history of the last three months preceding a toxin positive CDI test was recorded. Parameters, including ribotype of C...
July 25, 2018: Scandinavian Journal of Gastroenterology
Takuto Suzuki, Yoshiyasu Kitagawa, Rino Nankinzan, Hideyuki Takashiro, Taro Hara, Taketo Yamaguchi
PURPOSE: To examine the usefulness of non-magnified close observation with blue laser imaging (BLI) using a colonoscope with close observation capability in determining indications for cold polypectomy. METHODS: We conducted an image evaluation study on 100 consecutive colorectal lesions of 10 mm or less which were observed endoscopically without magnification using BLI mode prior to treatment. Two experts and two non-experts reviewed the images using the Japan NBI expert team (JNET) classification and the diagnostic accuracy was analyzed...
July 24, 2018: Scandinavian Journal of Gastroenterology
Matthias Orn Halldorsson, Michael Hauptmann, Petur Snaebjornsson, Kristín Huld Haraldsdóttir, Thor Aspelund, Elias Freyr Gudmundsson, Vilmundur Gudnason, Jon Gunnlaugur Jonasson, Sigurdis Haraldsdottir
OBJECTIVES: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the risk of a dMMR CRC by comparing CCY incidence in patients with dMMR CRC and proficient MMR (pMMR) CRC to unaffected controls. MATERIALS AND METHODS: All patients diagnosed with CRC in Iceland from 2000 to 2009 (n = 1171) were included...
July 16, 2018: Scandinavian Journal of Gastroenterology
Hyeong Seok Nam, Cheol Woong Choi, Su Jin Kim, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Dae Gon Ryu
OBJECTIVE: Endoscopic submucosal dissection (ESD) has been accepted as the treatment of choice for gastric epithelial neoplasia. Endoscopic characteristics of the primary lesion and post-ESD scars may be informative to predict the possibility of local recurrence. METHODS: Between November 2008 and July 2015, a retrospective study was conducted in a single-tertiary referral hospital. Consecutive patients who underwent ESD for early gastric cancer (EGC) or high-grade dysplasia were analyzed to evaluate the incidence of local recurrence and associated endoscopic characteristics...
July 16, 2018: Scandinavian Journal of Gastroenterology
David Drobne, Tina Kurent, Sasa Golob, Polona Svegl, Polona Rajar, Sara Terzic, Matic Kozelj, Gregor Novak, Natasa Smrekar, Samo Plut, Nejc Sever, Luka Strnisa, Jurij Hanzel, Jernej Brecelj, Darja Urlep, Josko Osredkar, Matjaz Homan, Rok Orel, Borut Stabuc, Ivan Ferkolj, Alojz Smid
OBJECTIVE: A prospective trial suggests target infliximab trough levels of 3-7 μg/mL, yet data on additional therapeutic benefits and safety of higher trough levels are scarce. AIM: To explore whether high infliximab trough levels (≥7 μg/mL) are more effective and still safe. MATERIAL AND METHODS: In this cohort study of 183 patients (109 Crohn's disease and 74 ulcerative colitis) on infliximab maintenance treatment at a tertiary referral center we correlated fecal calprotectin and C-reactive protein to trough levels (426 samples) at different time points during treatment...
July 10, 2018: Scandinavian Journal of Gastroenterology
Tea Lund Laursen, Cecilie Brøckner Siggard, Konstantin Kazankov, Thomas Damgaard Sandahl, Holger Jon Møller, Adrian Ong, Mark W Douglas, Jacob George, Britta Tarp, Lena Hagelskjaer Kristensen, Alex Lund Laursen, Akira Hiramatsu, Takashi Nakahara, Kazuaki Chayama, Henning Grønbaek
BACKGROUND AND AIM: Soluble CD 163 (sCD163) is released from activated liver macrophages in chronic viral hepatitis C (HCV) and serum levels reflect liver disease severity. The impact of direct-acting antiviral (DAA)-therapy on sCD163-levels and the ability of sCD163 to predict the presence of liver fibrosis remain unclear. In a combined observational and prospective study, we aimed to investigate changes in sCD163 with DAA-treatment, to investigate associations between sCD163 and histopathological activity and fibrosis and to validate the sCD163-based fibrosis score in HCV-patients...
July 10, 2018: Scandinavian Journal of Gastroenterology
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