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Scandinavian Journal of Gastroenterology

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https://www.readbyqxmd.com/read/28323552/helicobacter-pylori-eradication-in-the-swedish-population
#1
Eva Doorakkers, Jesper Lagergren, Vijaya Krishna Gajulapuri, Steven Callens, Lars Engstrand, Nele Brusselaers
OBJECTIVES: Helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7 days. Yet, other antibiotic regimens are sometimes prescribed. We aimed to assess the use of eradication therapy for H. pylori in the Swedish population during the last decade. MATERIALS AND METHODS: This population-based study used data from the Swedish Prescribed Drug Register...
March 21, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28301276/epigenetic-alterations-as-biomarkers-in-pancreatic-ductal-adenocarcinoma
#2
Pascal Syren, Roland Andersson, Monika Bauden, Daniel Ansari
Pancreatic ductal adenocarcinoma (PDAC) prognosis remains very poor and has only marginally improved during the last decades. Epigenetic alterations have been the focus of many recent studies and offer valuable options for PDAC detection, prognosis and treatment. DNA methylation, histone modifications and microRNA (miR) level changes can be used as biomarkers. These alterations occur early in carcinogenesis and may be specific for PDAC. Additionally, epigenetic alterations can be analyzed from cell-free DNA, free-circulating nucleosomes or shed tumor cells in blood...
March 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28290721/helicobacter-pylori-and-necessary-rationale-for-autoimmune-gastritis
#3
Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
March 14, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28281846/autoimmune-liver-diseases-and-inflammatory-bowel-diseases-in-children-current-issues-and-future-perspectives
#4
Sabrina Cardile, Tommaso Alterio, Manila Candusso, Andrea Pietrobattista, Daniela Liccardo, Maria Sole Basso, Bronislava Papadatou, Fiammetta Bracci, Daniela Knafelz, Giuliano Torre
Inflammatory bowel diseases (IBDs) represent a group of intestinal disorders with a chronic and relapsing inflammation of the gut, and with a potential risk of systemic involvement of other organs and systems. Over the pediatric age, an incidence higher than 20% of developing extraintestinal manifestation during follow-up has been reported. The liver and the biliary system are frequently involved, and primary sclerosing cholangitis (PSC) is the most predominant entity with an incidence rate of 6.4-7.8% in children...
March 10, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28281844/cxcr7-as-a-chemokine-receptor-for-sdf-1-promotes-gastric-cancer-progression-via-mapk-pathways
#5
Ameng Shi, Haitao Shi, Lei Dong, Shaoxian Xu, Miao Jia, Xiaoyan Guo, Ting Wang
OBJECTIVE: As the alternate receptor for stromal cell-derived factor-1 (SDF-1) except CXCR4, CXCR7 has been shown to be involved in the progression of some malignancies. However, the role of SDF-1/CXCR7 in gastric cancer (GC) remains unclear. MATERIALS AND METHODS: CXCR7 expression was examined in 83 human GC tissues and adjacent non-cancer tissues (ANCTs) by immunohistochemistry, in three human GC cell lines (MGC-803, BGC-823 and SGC-7901) by reverse transcription-PCR and western blot...
March 10, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28277895/serrated-polyps-a-concealed-but-prevalent-precursor-of-colorectal-cancer
#6
Henrik Thorlacius, Yoji Takeuchi, Takashi Kanesaka, Otto Ljungberg, Noriya Uedo, Ervin Toth
Serrated polyps have long been considered to lack malignant potential but accumulating data suggest that these lesions may cause up to one-third of all sporadic colorectal cancer. Serrated polyps are classified into three subtypes, including sessile serrated adenomas/polyps (SSA/Ps), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). SSA/P and TSA harbour malignant potential but TSA represents only 1-2%, wheras SSA/P constitute up to 20% of all serrated lesions. HPs are most common (80%) of all serrated polyps but are considered to have a low potential of developing colorectal cancer...
March 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28272905/g-protein-coupled-receptor-55-gpr55-expresses-differently-in-patients-with-crohn-s-disease-and-ulcerative-colitis
#7
Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Adam I Cygankiewicz, Damian Jacenik, Wanda M Krajewska, Krystyna Stec-Michalska, Aleksandra Piechota-Polańczyk, Maria Wiśniewska-Jarosińska, Jakub Fichna
AIM: To investigate the levels of G protein-coupled receptor 55 (GPR55) expression in colonic tissue of inflammatory bowel disease (IBD) patients and healthy controls, and its potential implication in IBD treatment. METHODS: Fifty patients were enrolled in our prospective study: n = 21 with Crohn's disease (CD) and n = 16 with ulcerative colitis (UC); 19 women and 18 men. Control consisted of 13 non-IBD patients. In each subject, two biopsies were taken from different colonic locations...
March 8, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28271924/serological-biomarkers-in-triage-of-fit-positive-subjects
#8
Hans J Nielsen, Ib Jarle Christensen, Berit Andersen, Morten Rasmussen, Lennart J Friis-Hansen, Thomas Bygott, Jake MiCallef
FIT-based colorectal cancer screening has been implemented in many countries including Denmark, where 916 colorectal cancer and 4468 high- or medium-risk adenoma patients were identified within April-December 2014, among 16,806 subjects with a positive FIT test. Screening increases the overall requirements for colonoscopy, which may challenge the current capacity. Some countries have increased their initial FIT cut-off level in order to comply with lack of colonoscopy capacity. Many patients with neoplasia will not be detected, however, by using increased FIT cut-off levels...
March 8, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276822/incidence-and-predictive-factors-for-positive-75-sehcat-test-improving-the-diagnosis-of-bile-acid-diarrhoea
#9
Iain Alexander Murray, Linzi Karen Murray, Kathy Louise Woolson, Hisham Sherfi, Ivor Dixon, Joanne Palmer, Tom Sulkin
AIMS: To determine the value of (75)SeHCAT retention in determining bile acid diarrhoea (BAD), treatment response and predictors of a positive result. METHODS: Retrospective casenote review of consecutive patients undergoing (75)SeHCAT from 2008 to 2014, including gender, age, history, clinical, and laboratory parameters. This included diseases associated with Type 1 BAD (ileal resection, Crohn's disease) and Type 3 BAD. Chi-squared test and logistic regression determined factors predictive of BAD...
March 5, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276824/clinical-profile-and-treatment-outcome-of-chronic-pancreatitis-in-children-a-long-term-follow-up-study-of-156-cases
#10
Ujjal Poddar, Surender Kumar Yachha, Vibhor Borkar, Anshu Srivastava, Vivek A Saraswat
AIM: There is a paucity of literature in pediatric chronic pancreatitis (CP) and most information is derived from adult literature. We, therefore, analyzed our experience of CP to look for clinical profile and long-term outcome. METHODS: From January 2003 to December 2015, 156 consecutive children (≤18 years) diagnosed as CP were included. Their clinical profile, management, and follow-up data were retrieved. Genetic markers (PRSS1, SPINK1, and CFTR) were studied in 40 idiopathic cases...
March 1, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276823/the-role-of-malat-1-in-the-invasion-and-metastasis-of-gastric-cancer
#11
Di Chen, Lili Liu, Kai Wang, Haiyan Yu, Yafang Wang, Jiaming Liu, Yang Guo, Hongbo Zhang
OBJECTIVES: The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) has been reported to be over-expressed in several cancer types. However, its role in gastric cancer (GC) remains unclear. In the present study, we examined the expression of MALAT-1 in GC cells and tissues and explored its role in GC cell migration and invasion. MATERIALS AND METHODS: Real-time quantitative polymerase chain reaction (qRT-PCR) was used to analyze the expression level of MALAT-1 in six GC cell lines and 20 gastric tissues (20 GC and 20 adjacent normal mucosa)...
March 1, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276829/chronic-cholestatic-liver-diseases
#12
Helge L Waldum, Einar S Björnsson, Eiliv Brenna
No abstract text is available yet for this article.
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276828/the-nescience-and-nascence-of-gastrointestinal-motility-research-in-acute-pancreatitis
#13
Maxim S Petrov
No abstract text is available yet for this article.
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276827/direct-endoscopic-biopsy-for-subepithelial-tumor-larger-than-20%C3%A2-mm-after-removal-of-overlying-mucosa
#14
Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Sun Hwi Hwang, Si Hak Lee
OBJECTIVE: An accurate diagnosis of a subepithelial tumor (SET) using endoscopic ultrasound (EUS) without tissue acquisition is difficult. Treatment plan for a SET may be influenced by endoscopic tissue diagnosis. We aimed to clarify the clinical outcomes of direct endoscopic biopsy for SET after removal of the overlying mucosa. METHODS: We evaluated the medical records of 15 patients. All patients underwent direct endoscopic biopsy for a SET larger than 20 mm (involving proper muscle layer) after removal of the overlying mucosa...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276826/lifetime-drinking-history-in-patients-with-alcoholic-liver-disease-and-patients-with-alcohol-use-disorder-without-liver-disease
#15
Jon Kristinn Nielsen, Sigurdur Olafsson, Ottar M Bergmann, Valgerdur Runarsdottir, Ingunn Hansdottir, Ragna Sigurdardottir, Einar S Björnsson
OBJECTIVE: To determine the differences in lifetime alcohol intake (LAI) and drinking patterns between patients with alcoholic liver disease (ALD) and alcohol use disorder (AUD) without notable liver injury and between males and females with ALD. METHODS: Alcohol drinking patterns were assessed using the Lifetime Drinking History (LDH) a validated questionnaire, during an outpatient visit. Patients with AUD, currently in addiction treatment, were matched for gender and age (±5 years) with the ALD group...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276825/perioperative-chemotherapy-for-resectable-gastric-cancer-what-is-the-evidence
#16
Erling A Bringeland, Hans H Wasmuth, Jon E Grønbech
The UK MAGIC trial published in 2006 was the first RCT to identify improved long-term survival rates using preoperative chemotherapy for resectable gastric or gastroesophageal cancer. Overnight, the treatment regimen impacted European guidelines. However, the majority of patients underwent limited lymph node dissection, and analyses of the rates of curative resection, downsizing and downstaging were not by intention to treat, rightfully raising concerns about their validity. For the subset of true gastric cancers, meta-analyses may even question the claims of improved long-term survival rates by present-day regimens...
February 28, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276831/pancreatic-cancer-stroma-controversies-and-current-insights
#17
Daniel Ansari, Maria Carvajo, Monika Bauden, Roland Andersson
Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma...
February 24, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276830/bariatric-surgery-time-to-replace-with-glp-1
#18
Dominic-Luc Webb, Niclas Abrahamsson, Magnus Sundbom, Per M Hellström
Obesity with a body mass index (BMI) over 30 kg/m(2) represents a significant risk for increased morbidity and mortality, with reduced life expectancy of about 10 years. Until now, surgical treatment has been the only effective longterm intervention. The currently standardized method of bariatric surgery, gastric bypass, means that many gastrointestinal peptide hormones are activated, yielding net reductions in appetite and food intake. Among the most important gut peptide hormones in this perspective is glucagon-like peptide-1 (GLP-1), which rises sharply after gastric bypass...
February 24, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276832/the-incidence-and-outcome-of-ischemic-colitis-in-a-population-based-setting
#19
Y Yngvadottir, B R Karlsdottir, J P Hreinsson, G Ragnarsson, R U M Mitev, J G Jonasson, P H Möller, E S Björnsson
OBJECTIVE: Population-based studies on patients with ischemic colitis (IC) are limited. We aimed to determine the incidence, risk factors and outcome of patients with IC. METHODS: A retrospective nationwide study was conducted on adult patients with histologically confirmed IC in 2009-2013 in Iceland. IC patients were matched for age and gender with patients hospitalized with lower gastrointestinal bleeding. Data were collected on clinical presentation, comorbidities, smoking habits, management and outcome...
February 23, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276833/adjuvant-transarterial-chemoembolization-for-patients-after-curative-resection-of-hepatocellular-carcinoma-a-meta-analysis
#20
Mingheng Liao, Zexin Zhu, Haichuan Wang, Jiwei Huang
OBJECTIVE: To evaluate the efficacy and safety of adjuvant transarterial chemoembolization (TACE) after curative hepatectomy in improving the survival of patients with primary hepatocellular carcinoma (HCC). METHODS: MEDLINE, Embase and the Cochrane Library were searched for randomized or nonrandomized studies comparing postoperative adjuvant TACE with curative resection alone. Meta-analysis was performed after converting time-event data into a hazard ratio (HR), using an inverse diversity model...
February 22, 2017: Scandinavian Journal of Gastroenterology
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