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Clinical and Experimental Immunology

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https://www.readbyqxmd.com/read/28898406/dc-sign-reacts-with-tlr4-and-regulates-inflammatory-cytokine-expression-via-nf-%C3%AE%C2%BAb-activation-in-renal-tubular-epithelial-cells-during-acute-renal-injury
#1
Danying Feng, Yanping Wang, Yan Liu, Liping Wu, Xiao Li, Yufan Chen, Yuanyuan Chen, Yafeng Chen, Chundi Xu, Ke Yang, Tong Zhou
In the pathological process of acute kidney injury (AKI), innate immune receptors are essential in inflammatory response modulation; however, the precise molecular mechanisms are still unclear. Our study sought to demonstrate the inflammatory response mechanisms in renal tubular epithelial cells via Toll-like receptor 4 (TLR4) and dendritic cell-specific ICAM-3-grabbing non-integrin 1 (DC-SIGN) signaling. We found that DC-SIGN exhibited strong expression in renal tubular epithelial cells of human acute renal injury tissues...
September 12, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28898393/is-beh%C3%A3-et-s-disease-a-class-1-opathy-the-role-of-hla-b-51-in-the-pathogenesis-of-beh%C3%A3-et-s-disease
#2
REVIEW
Mark Giza, Danai Koftori, Liye Chen, Paul Bowness
The association between carriage of the HLA-B*51 allele and development of Behçet's Disease (BD) has been known since the early 1970s, but the exact mechanisms responsible for its role in pathogenesis remain much-debated. In an effort to explain the disease process, it has been suggested that BD constitutes one of a newly-termed group of diseases, the 'MHC-I-opathies'. Other MHC-I-opathies' include Ankylosing Spondylitis and other HLA-B*27-associated spondyloarthropathies, and HLA-C*0602-associated skin psoriasis...
September 12, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28884475/chronic-exposure-of-interleukin-13-suppress-the-induction-of-matrix-metalloproteinase-1-by-tumor-necrosis-factor-%C3%AE-in-normal-and-scleroderma-dermal-fibroblasts-through-protein-kinase-b-akt
#3
Monica L Brown Lobbins, Bangalore R Shivakumar, Arnold E Postlethwaite, Karen A Hasty
OBJECTIVE: Peripheral blood mononuclear cells taken from patients with scleroderma express increased levels of IL-13. Moreover, the expression of MMP-1 from involved scleroderma skin fibroblasts is refractory to stimulation by tumor necrosis factor alpha. To elucidate the mechanism(s) involved, we examined the effect of IL-13 on TNF-α-induced matrix metalloproteinase-1 expression in normal and scleroderma human dermal fibroblast lines and studied the involvement of serine/threonine kinase B/Akt in this response...
September 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28876451/selective-hdac6-inhibition-decreases-early-stage-of-lupus-nephritis-by-downregulating-both-innate-and-adaptive-immune-responses
#4
Jingjing Ren, Xiaofeng Liao, Miranda D Vieson, Miao Chen, Reilly Scott, Jillian Kazmierczak, Xin M Luo, Christopher M Reilly
We have previously demonstrated that HDAC6 expression is increased in animal models of systemic lupus erythematosus (SLE) and that inhibition of HDAC6 decreased disease. In our current studies, we tested if an orally active selective HDAC6 inhibitor would decrease disease pathogenesis in a lupus mouse model with established early disease. Additionally, we sought to delineate the cellular and molecular mechanism(s) of action of a selective HDAC6 inhibitor in SLE. We treated 20-week-old (early-disease) NZB/W F1 female mice with two different doses of the selective HDAC6 inhibitor (ACY-738) for five weeks...
September 6, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28872665/expression-of-human-cathelicidin-peptide-ll-37-in-inflammatory-bowel-disease
#5
Shoko Kusaka, Atsushi Nishida, Kenichiro Takahashi, Shigeki Bamba, Hiroyuki Yasui, Masahiro Kawahara, Osamu Inatomi, Mitsushige Sugimoto, Akira Andoh
Cathelicidin peptide LL-37 plays an important role in the early host response against invading pathogens via its broad-spectrum antimicrobial activity. In this study, we investigated LL-37 expression in the inflamed mucosa of IBD patients. Furthermore, the regulatory mechanism of LL-37 induction was investigated in human colonic subepithelial myofibroblasts (SEMFs). LL-37 mRNA expression and protein secretion were analyzed using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively...
September 5, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28868628/ovarian-cancer-stem-cells-promote-tumour-immune-privilege-and-invasion-via-ccl5-and-regulatory-t-cells
#6
Yanan You, Yiying Li, Ming Li, Lei Mi, Mengyao Wu, Ying Qu, Yan Yuan, Tong Chen, Hua Jiang
Emerging evidence indicates a link between the increased proportion of regulatory T cells (Tregs) and reduced survival in patients who have been diagnosed with cancer. Cancer stem cells (CSCs) have been indicated to play a vital role in tumour initiation, drug resistance and recurrence. However, the relationship between Tregs and CSCs remains largely unknown. Here, we sorted out ovarian cancer stem-like side population (SP) cells and CD133(+) cells to investigate the influence of ovarian CSCs on Tregs. Among the various immune-related molecules that we assessed, C-C motif chemokine ligand 5 (CCL5) was the most elevated in ovarian CSCs relative to that in the non-CSCs...
September 4, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28862740/dynamics-of-m1-macrophages-in-oral-mucosal-lesions-during-the-development-of-acute-graft-versus-host-disease-in-rats
#7
Kei Seno, Madoka Yasunaga, Hiroshi Kajiya, Kanako Izaki-Hagio, Hiromitsu Morita, Masahiro Yoneda, Takao Hirofuji, Jun Ohno
The role of macrophage infiltrates in oral mucosal acute graft-versus-host disease (AGVHD) remains unclear, although clinical studies suggest that macrophage infiltration correlates directly with the severity of AGVHD. In this study, we investigated the role of M1 macrophage infiltration in the oral mucosa of rats with AGVHD. Lewis rat spleen cells were injected into (Lewis x Brown Norway) F1 rats to induce systemic GVHD. Tongue samples were evaluated using histology, immunohistochemistry, dual immunofluorescence, real-time reverse transcription-polymerase chain reaction, transwell migration assays, and Stamper-Woodruff binding assays...
September 1, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28856667/respiratory-syncytial-virus-infection-influences-tight-junction-integrity
#8
Jeannette I Kast, Amanda J McFarlane, Anna Głobińska, Milena Sokolowska, Paulina Wawrzyniak, Marek Sanak, Jürgen Schwarze, Cezmi A Akdis, Kerstin Wanke
Background Respiratory syncytial virus (RSV) is an important risk factor of asthma development and is responsible for severe respiratory tract infections. However, the influence of RSV infection on barrier function of bronchial epithelial cells in vitro and in vivo is still unclear. Objective The aim of this study was to analyze the role of RSV in tight junction (TJ) regulation and to compare epithelial integrity between asthmatic and healthy individuals upon RSV infection. Methods Healthy and asthmatic human bronchial epithelial cells (HBECs) were differentiated at air-liquid interface (ALI) and infected with RSV and UV-irradiated RSV...
August 30, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28836661/self-dsdna-in-the-pathogenesis-of-systemic-lupus-erythematosus
#9
REVIEW
Yunqiang Bai, Yanli Tong, Yi Liu, Hongbo Hu
Systemic lupus erythematosus (SLE) is a systemic and polyetiological autoimmune disease characterized by the production of antibodies to autologous double stranded DNA (dsDNA) which serve as the diagnostic and prognostic marker. Defective clearance of apoptotic material, together with neutrophil extracellular traps (NETs), provides abundant chromatin or self-dsDNA to trigger the production of anti-dsDNA antibodies, although the mechanisms remain to be elucidated. In SLE patients, immune complexes (IC) of dsDNA and its autoantibodies, triggers the robust type I interferon (IFN-I) production through intracellular DNA sensors, which drives the adaptive immune system to break down self-tolerance...
August 24, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28834574/baff-and-baff-receptors-fakes-and-facts
#10
Gianfranco Ferraccioli, Elisa Gremese
The analysis of BAFF receptors before and after B cell depletion therapy (BCDT) might offer a clue to understand whether some B cell subsets, may represent useful biomarkers of biological and clinical response. Among the BAFF receptors, the AA have shown in a cohort of rheumatoid arthritis (RA) patients, by FACS analysis of the MFI (median fluorescence intensity) that TACI, and BCMA, do not change whereas BR3, the most important, appears to be decreased either before as well as after BCDT, in all B cells subsets but not in Plasmablasts, the subset more important and depleted by BCDT ...
August 23, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28832994/c4b-gene-influences-intestinal-microbiota-through-complement-activation-in-patients-with-pediatric-onset-inflammatory-bowel-disease
#11
Eija Nissilä, Katri Korpela, A Inkeri Lokki, Riitta Paakkanen, Sakari Jokiranta, Willem de Vos, Marja-Liisa Lokki, Kaija-Leena Kolho, Seppo Meri
Complement C4 genes are linked to pediatric inflammatory bowel disease (PIBD), but the mechanisms have remained unclear. We examined the influence of C4B gene number on intestinal microbiota and in vitro serum complement activation by intestinal microbes in PIBD patients. Complement C4A and C4B gene numbers were determined by genomic RT-PCR from 64 patients with PIBD (Crohn's disease or ulcerative colitis). The severity of the disease course was determined from fecal calprotectin levels. Intestinal microbiota was assessed using the HITChip microarray...
August 23, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28833034/rheumatoid-arthritis-fibroblast-like-synoviocytes-cocultured-with-pbmc-increased-peripheral-cd4-cxcr5-icos-t-cells-numbers
#12
Yawei Tang, Bing Wang, Xiaotong Sun, Han Li, Xunli Ouyang, Jing Wei, Bingbing Dai, Yan Zhang, Xia Li
"Circulating" T follicular helper (Tfh) cells, characterized by their surface phenotypes CD4+CXCR5+ICOS+, have been identified as the CD4+ T cell subset specialized in supporting the activation, expansion and differentiation of B cells. Fibroblast-like synoviocytes (FLS) are critical in promoting inflammation and cartilage destruction in rheumatoid arthritis (RA), and the interaction between FLS and T cells is considered to facilitate FLS activation and T cells recruitment. However, it remains unknown whether RA-FLS cocultured with activated peripheral blood mononuclear cells (PBMC) has immunoregulatory effects on peripheral Tfh cells...
August 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28815559/characteristic-elevation-of-soluble-tnf-receptor-ii-to-i-ratio-in-macrophage-activation-syndrome-with-systemic-juvenile-idiopathic-arthritis
#13
Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie
To investigate the clinical significance of soluble tumor necrosis factor receptor (sTNFR) II/I ratio as an indicator of the diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA), we measured the serum sTNFRI and II levels in 117 patients with s-JIA, including 29 patients with MAS, 15 with Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis (EBVHLH), 15 with Kawasaki disease (KD), and 28 healthy controls (HCs). We determined their correlation with measurements of disease activity and severity...
August 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28800164/b-cell-phenotypes-in-patients-with-rheumatoid-arthritis-relapsing-after-rituximab-expression-of-b-cell-activating-factor-binding-receptors-on-b-cell-subsets
#14
Elena Becerra, Inmaculada De La Torre, Maria J Leandro, Geraldine Cambridge
OBJECTIVES: Serum levels of B cell activating factor (BAFF) rise following Rituximab (RTX) therapy in patients with Rheumatoid arthritis (RA). Initiation of naïve B cell return to the periphery and autoreactive B cell expansion leading to relapse after RTX may therefore be linked to interactions between BAFF and BAFF-binding receptors (BBR). METHODS: Relationships between serum BAFF and BBR expression (BAFFR, TACI and BCMA) were determined on B cell subsets, defined using IgD/CD38...
August 11, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28779554/cytokine-responses-to-exercise-and-activity-in-patients-with-chronic-fatigue-syndrome-case-control-study
#15
L V Clark, M Buckland, G Murphy, N Taylor, V Vleck, C Mein, E Wozniak, M Smuk, P D White
Chronic fatigue syndrome (CFS) is characterized by fatigue after exertion. A systematic review suggested that transforming growth factor beta (TGF-β) concentrations are often elevated in cases of CFS when compared to healthy controls. This study attempted to replicate this finding, and investigate whether post-exertional symptoms were associated with altered cytokine protein concentrations and their RNA in CFS patients. Twenty-four patients fulfilling Centers for Disease Control criteria for CFS, but with no comorbid psychiatric disorders, were recruited from two CFS clinics in London, UK...
August 5, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28763101/relevant-genetic-polymorphisms-and-kidney-expression-of-tlr5-and-tlr9-in-lupus-nephritis
#16
Nesrine Elloumi, Raouia Fakhfakh, Olfa Abida, Lobna Ayadi, Sameh Marzouk, Hend Hachicha, Mohamed Fourati, Zouhir Bahloul, Mohamed Nabil Mhiri, Khawla Kammoun, Hatem Masmoudi
Toll-like receptor (TLR) genetic polymorphisms may modify their expression causing inflammatory disorders and influencing both susceptibility and severity of lupus erythematosus. We aim to determine whether TLR5 and TLR9 genes polymorphisms are implicated in the susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN) and to evaluate their expressions and distributions in renal LN patients' biopsies. The frequencies of 2 SNP in TLR9 gene and 1 in TLR5 gene was examined in 106 SLE patients (among them 37 LN patients) and in 200 matched controls by PCR-RFLP analysis...
August 1, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28763100/fungal-derived-cues-promote-ocular-autoimmunity-through-a-dectin-2-card9-mediated-mechanism
#17
Brieanna R Brown, Ellen J Lee, Paige E Snow, Emily E Vance, Yoichiro Iwakura, Naohito Ohno, Noriko Miura, Xin Lin, Gordon D Brown, Christine A Wells, Justine R Smith, Rachel R Caspi, Holly L Rosenzweig
Uveitis (intraocular inflammation) is a leading cause of vision loss. Although its etiology is largely speculative, it is thought to arise from complex genetic-environmental interactions that break immune tolerance to generate eye-specific autoreactive T cells. Experimental autoimmune uveitis (EAU), induced by immunization with the ocular antigen, interphotoceptor retinoid binding protein (IRBP), in combination with mycobacteria-containing CFA, has many clinical and histopathological features of human posterior uveitis...
August 1, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28759104/the-interplay-between-hla-b27-and-erap1-erap2-aminopeptidases-from-antiviral-protection-to-spondyloarthritis
#18
REVIEW
Carolina Vitulano, Valentina Tedeschi, Fabiana Paladini, Rosa Sorrentino, Maria Teresa Fiorillo
The human leukocyte antigen class I gene HLA-B27 is the strongest risk factor for Ankylosing Spondylitis (AS), a chronic inflammatory arthritic disorder. More recently, the Endoplasmic Reticulum Aminopeptidases (ERAP) 1 and 2 genes have been identified by genome-wide association studies (GWAS) as additional susceptibility factors. In the ER, these aminopeptidases trim the peptides to a length suitable to fit into the groove of the MHC class I molecules. Noteworthy, an epistatic interaction between HLA-B27 and ERAP1, but not between HLA-B27 and ERAP2, has been highlighted...
July 31, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28752628/intranasal-delivery-of-dexamethasone-efficiently-controls-lps-induced-murine-neuroinflammation
#19
G Meneses, G Gevorkian, A Florentino, M A Bautista, A Espinosa, G Acero, G Díaz, A Fleury, I N Pérez Osorio, A Del Rey, G Fragoso, E Sciutto, H Besedovsky
Neuroinflammation is the hallmark of several infectious and neurodegenerative diseases. Synthetic glucocorticoids (GCs) are the first-line immunosuppressive drugs used for controlling neuroinflammation. A delayed diffusion of GCs molecules and the high systemic doses required for brain-specific targeting lead to severe undesirable effects, particularly when lifelong treatment is required. Therefore, there is an urgent need for improving this current therapeutic approach. The intranasal (i.n.) route is being employed increasingly for drug delivery to the brain via the olfactory system...
July 28, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28752543/exonal-switch-down-regulates-the-expression-of-cd5-on-blasts-of-acute-t-cell-leukemia
#20
Ambak Kumar Rai, Amar Singh, Ankit Saxena, Tulika Seth, Vinod Raina, Dipendra Kumar Mitra
CD5 expression and its role in acute T cell lymphoblastic leukemia (T-ALL) have not been elaborately studied so far. We observed a significant reduction in surface expression of CD5 (sCD5) on leukemic T cells compared to autologous non-leukemic T cells. In this study, we have shown the molecular mechanism regulating the expression and function of CD5 on leukemic T cells. Total 250 numbers of patients suffering from leukemia and lymphoma were immunophenotyped. Final diagnosis was based on their clinical presentation, morphological data and flowcytometry based immunophenotyping...
July 28, 2017: Clinical and Experimental Immunology
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