journal
MENU ▼
Read by QxMD icon Read
search

Clinical and Experimental Immunology

journal
https://www.readbyqxmd.com/read/28213939/protective-antibodies-against-clostridium-difficile-are-present-in-intravenous-immunoglobulin-and-are-retained-in-humans-following-its-administration
#1
Ola H Negm, Brendon MacKenzie, Mohamed R Hamed, Omar Aj Ahmad, Clifford C Shone, David P Humphreys, K Ravi Acharya, Christine E Loscher, Izabela Marszalowska, Mark Lynch, Mark H Wilcox, Tanya M Monaghan
The prevalence of serum antibodies against C. difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recurrent C. difficile infection (CDI). Despite some promising case reports, a definitive clinical role for IVIg in CDI remains unclear. Contradictory results may be attributed to a lack of consensus regarding optimal dose, timing of administration and patient selection as well as variability in specific antibody content between commercial preparations...
February 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28205212/sarcoidosis-extent-relates-to-molecular-variability
#2
Calixte S Monast, Katherine Li, Marc A Judson, Robert P Baughman, Eric Wadman, Rosemary Watt, Philip E Silkoff, Elliot S Barnathan, Carrie Brodmerkel
The molecular basis of sarcoidosis phenotype heterogeneity and its relationship to effective treatment of sarcoidosis have not been elucidated. Peripheral samples from sarcoidosis subjects who participated in a phase 2 study of golimumab (anti-TNFα) and ustekinumab (anti-IL12p40) were used to measure the whole blood transcriptome and levels of serum proteins. Differential gene and protein expression analyses were used to explore the molecular differences between sarcoidosis phenotypes as defined by extent of organ involvement...
February 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28194776/mutational-spectrum-of-the-serping1-gene-in-swiss-patients-with-hereditary-angioedema
#3
Urs C Steiner, Melanie Keller, Pirmin Schmid, Sven Cichon, Walter A Wuillemin
Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare autosomal dominant disease caused by mutations in the C1 inhibitor gene SERPING1. Phenotype and clinical features of the disease are very heterogeneous, varying even in the same family. Compared to HAE cohorts in other countries the genetic background of the Swiss HAE patients has not been elucidated yet. In the present study we investigated the mutational spectrum of the SERPING1 gene in nineteen patients of nine unrelated Swiss families...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28194759/association-of-peripheral-nk-cell-counts-with-helios-ifny-tregs-in-patients-with-good-long-term-renal-allograft-function
#4
Karina Trojan, Li Zhu, Mostafa Aly, Rolf Weimer, Nuray Bulut, Christian Morath, Gerhard Opelz, Volker Daniel
BACKGROUND: Little is known about a possible interaction of NK cells with Tregs in long-term stable kidney transplant recipients. METHODS: Absolute counts of lymphocyte and Treg subsets were studied in whole blood samples of 136 long-term stable renal transplant recipients and 52 healthy controls using eight-color-fluorescence flow cytometry. Patients were 1946±2201 days (153-10268 days) posttransplant and showed a serum creatinine of 1.7±0.7 mg/dl. RESULTS: Renal transplant recipients investigated >1...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28194756/chlorhexidine-allergy-in-4-specialist-allergy-centres-in-the-uk-2009-2013-clinical-features-and-diagnostic-tests
#5
William Egner, Matthew Helbert, Ravishankar Sargur, Kirsty Swallow, Nigel Harper, Tomaz Garcez, Sinisa Savic, Louise Savic, Eren Effren
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the UK following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and sIgE testing were the most common tests used for diagnosis. Fifty-three % of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50-86%), 50% (10-90%) and 35% (17-55%) respectively...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28194750/differential-responses-of-human-dendritic-cells-to-metabolites-from-the-oral-airway-microbiome
#6
Katrine Whiteson, Sudhanshu Agrawal, Anshu Agrawal
Small molecule metabolites that are produced or altered by host-associated microbial communities are emerging as significant immune response modifiers. However, there is a key gap in our knowledge of how oral microbial metabolites affect the immune response. Here, we examined the effects of metabolites from five bacterial strains commonly found in the oral/airway microbial communities of humans. The five strains, each isolated from cystic fibrosis patient sputum, were Pseudomonas aeruginosa FLR01 non-mucoid (P1) and FLR02 mucoid (P2) forms, Streptococcus pneumoniae (Sp), Streptococcus salivarius (Ss), and Rothia mucilaginosa (Rm)...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28176332/low-dose-interleukin-2-promotes-stat5-phosphorylation-treg-survival-and-ctla-4-dependent-function-in-autoimmune-liver-diseases
#7
Hannah C Jeffery, Louisa E Jeffery, Philipp Lutz, Margaret Corrigan, Gwilym J Webb, Gideon M Hirschfield, David H Adams, Ye Htun Oo
CD4(+) CD25(high) CD127(low) FOXP3(+) regulatory T cells (Treg) are essential for the maintenance of peripheral tolerance. Impaired Treg function and an imbalance between effector and regulatory T cells contribute to the pathogenesis of autoimmune diseases. We recently reported that the hepatic microenvironment is deficient in IL-2, a cytokine essential for Treg survival and function. Consequently, few liver-infiltrating Treg demonstrate STAT5 phosphorylation. To establish the potential of IL-2 to enhance Treg therapy, we investigated the effects of very low dose Proleukin (VLDP) on the phosphorylation of STAT5 and the subsequent survival and function of Treg and T effector cells from the blood and livers of patients with autoimmune liver diseases...
February 8, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28170096/circulating-nk-cells-and-their-subsets-in-beh%C3%A3-et-s-disease
#8
Md Samiul Hasan, Paul L Ryan, Lesley A Bergmeier, Farida Fortune
Behçet's Disease (BD) is an auto-inflammatory, chronic relapsing/remitting disease of unknown aetiology with both innate and acquired immune cells implicated in disease pathogenesis. Peripheral blood Natural Killer (NK) cells and their CD56(Dim) /CD56(Bright) subsets were surface phenotyped using CD27 and CD16 surface markers in 60 BD patients compared to 60 healthy controls (HCs). Functional potential was assessed by production of interferon (IFN)-γ, Granzyme B, Perforin and the expression of degranulation marker CD107a...
February 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28152574/glucocorticoids-improve-endothelial-function-in-rheumatoid-arthritis-a-study-in-rats-with-adjuvant-induced-arthritis
#9
Frank Verhoeven, Perle Totoson, Katy Maguin-Gaté, Anne Prigent-Tessier, Christine Marie, Daniel Wendling, Johnny Moretto, Clément Prati, Céline Demougeot
AIMS: To determine the effect of glucocorticoids (GCs) on endothelial dysfunction (ED) and on traditional cardiovascular (CV) risk factors in the adjuvant-induced arthritis (AIA) rat model. METHODS: At the first signs of AIA, high dose (10 mg/kg/day, i.p., GC-HD) or low dose (1 mg/kg/day, i.p., GC-LD) of prednisolone was administered for 3 weeks. Endothelial function was studied in aortic rings relaxed with acetylcholine (Ach) with or without inhibitors of NOS, COX-2, Arginase, EDHF and superoxide anions (O2(-) °) production...
February 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28152566/exacerbation-of-spontaneous-autoimmune-nephritis-following-regulatory-t-cell-depletion-in-bim-knockout-mice
#10
Yuan Min Wang, Geoff Yu Zhang, Ya Wang, Min Hu, Jimmy Jianheng Zhou, Andrew Sawyer, Qi Cao, Yiping Wang, Guoping Zheng, Vincent W S Lee, David C H Harris, Stephen I Alexander
Regulatory T cells (Tregs) have been recognised as central mediators for maintaining peripheral tolerance and limiting autoimmune diseases. Loss of Tregs or their function has been associated with exacerbation of autoimmune disease. However, the temporary loss of Tregs in chronic spontaneous disease model has not been investigated. In this study, we evaluated the role of Tregs in a novel chronic spontaneous glomerulonephritis model of B cell lymphoma 2-interacting mediator (Bim) knockout mice by transient depleting Tregs...
February 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28142207/fc%C3%AE-receptor-expression-on-splenic-macrophages-in-adult-immune-thrombocytopenia
#11
Sylvain Audia, Kim Santegoets, Annemieke G Laarhoven, Gestur Vidarsson, Olivier Facy, Pablo Ortega-Deballon, Maxime Samson, Nona Janikashvili, Philippe Saas, Bernard Bonnotte, Timothy Radstake
Splenic macrophages play a key role in immune thrombocytopenia (ITP) pathogenesis by clearing opsonized platelets. Fcγ receptors (FcγR) participate to this phenomenon but their expression on splenic macrophages and their modulation by treatments have scarcely been studied in human ITP. We aimed to compare the phenotype and function of splenic macrophages, between six controls and 24 ITP patients, and between ITP patients according to the treatments they received prior to splenectomy. CD86, HLA-DR and FcγR expression were measured by flow cytometry on splenic macrophages...
January 31, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28142201/lymph-node-and-circulating-t-cell-characteristics-are-strongly-correlated-in-end-stage-renal-disease-patients-but-highly-differentiated-t-cells-reside-within-the-circulation
#12
Burç Dedeoglu, Annelies E de Weerd, Ling Huang, Anton W Langerak, Frank J Dor, Mariska Klepper, Wenda Verschoor, Derek Reijerkerk, Carla C Baan, Nicolle H R Litjens, Michiel G H Betjes
BACKGROUND: Ageing is associated with changes in the peripheral T-cell immune system, which can be significantly influenced by latent cytomegalovirus (CMV) infection. To what extent changes in circulating T-cell populations correlate with T-cell composition of the lymph node (LN) is unclear, but crucial for a comprehensive understanding of the T-cell system. METHODS: T cells from peripheral blood (PB) and LN of end-stage renal disease patients were analyzed for frequency of recent thymic emigrants using CD31 expression and T-cell receptor excision circle content, relative telomere length and expression of differentiation markers...
January 31, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28142190/sickle-cell-trait-is-associated-with-controlled-levels-of-heme-and-mild-pro-inflammatory-response-during-acute-malaria-infection
#13
Temitope W Ademolue, Olukemi K Amodu, Gordon A Awandare
The controlled induction of hemeoxygenase-1 (HO-1), an enzyme that catabolizes heme, has been shown to reduce heme, preventing pathologies associated with heme toxicity. The hemoglobin genotype HbAS confers reduced susceptibility to severe complications of malaria by a mechanism that is not well understood. Using a longitudinal approach, we investigated the effect of baseline concentrations of HO-1 on the accumulation of heme during acute Plasmodium falciparum malaria in HbAS and HbAA genotypes. Plasma concentrations of heme, HO-1, and cytokines were quantified in venous blood obtained from children (9 months-5 years of age) during malaria infection, and at convalescence (baseline levels)...
January 31, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28128853/pad4-inhibition-is-sufficient-for-the-amelioration-of-collagen-induced-arthritis
#14
Van C Willis, Nirmal K Banda, Kristen N Cordova, Piyanka E Chandra, William H Robinson, David C Cooper, Dave Lugo, Gaurav Mehta, Simon Taylor, Paul P Tak, Rab K Prinjha, Huw D Lewis, V Michael Holers
Citrullination of joint proteins by the PAD family of enzymes is increasingly recognized as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a novel PAD4-selective inhibitor, GSK199, in the murine collagen-induced arthritis model of rheumatoid arthritis. Mice were dosed daily from the time of collagen immunization with GSK199. Efficacy was assessed against a wide range of endpoints, including clinical disease scores, joint histology and immunohistochemistry, serum and joint citrulline levels, and quantification of synovial autoantibodies using a proteomic array containing joint peptides...
January 27, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28128850/transplantation-tolerance-the-big-picture-where-do-we-stand-where-should-we-go
#15
Herman Waldmann
A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance so as to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, and propose a three stage tolerance-inducing strategy for transplanted tissues. This article is protected by copyright. All rights reserved.
January 27, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28120479/urinary-haptoglobin-alpha-1-anti-chymotrypsin-and-retinol-binding-protein-identified-by-proteomics-as-potential-biomarkers-for-lupus-nephritis
#16
Amita Aggarwal, Ranjan Gupta, V S Negi, Liza Rajasekhar, Ramnath Misra, Padam Singh, Vinita Chaturvedi, Sudhir Sinha
OBJECTIVE: Identification by proteomics and validation by ELISA of potential urinary biomarkers for lupus nephritis. METHODS: Study subjects comprised 88 systemic lupus erythematosus (SLE) patients and 60 controls (rheumatoid arthritis, diabetes mellitus and healthy individuals). Based on SLE disease activity index (SLEDAI) patients were classified as active renal (AR), active non-renal (ANR) or inactive disease (ID).Urinary proteins from a group of patients with AR or ID were resolved by two-dimensional gel electrophoresis and identified by MALDI-TOF-MS/MS...
January 24, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28120329/constitutive-expression-of-the-anti-apoptotic-bcl-2-family-member-a1-in-murine-endothelial-cells-leads-to-transplant-tolerance
#17
Lesley A Smyth, Lucy Meader, Fang Xiao, Martin Woodward, Hugh J Brady, Robert Lechler, Giovanna Lombardi
Anti-apoptotic genes including those of the Bcl-2 family have been shown to have dual functionality in as much as they inhibit cell death but also regulate inflammation. Several anti-apoptotic molecules have been associated with endothelial cell (EC) survival following transplantation however their exact role has yet to be elucidated in respect to controlling inflammation. In this study we created mice expressing murine A1 (Bfl-1), a Bcl-2 family member, under the control of the human ICAM-2 promoter. Constitutive expression of A1 in murine vascular ECs conferred protection from cell death induced by the pro-inflammatory cytokine TNF-α...
January 24, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28108980/the-influence-of-macrophages-on-mesenchymal-stromal-cell-therapy-passive-or-aggressive-agents
#18
REVIEW
F Carty, B P Mahon, K English
Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date; recently, however, a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to design more effective MSC therapies and clinical studies...
January 20, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28100001/transplantation-tolerance-don-t-forget-about-the-b-cells
#19
REVIEW
Anita S Chong, Stella H Khiew
Establishing a state of transplantation tolerance that leads to indefinite graft survival without the need for lifelong immunosuppression has been successfully achieved in limited numbers of transplant recipients in the clinic. These successes led to studies aimed at identifying potential biomarkers that diagnose allograft tolerance and identify the patients most amenable to drug minimization, and implicated an enriched B cell signature of tolerance. The emergence of a specialized subset of regulatory B cell (Bregs) that possess immune-modulatory function in inflammation and autoimmune disease, raised the possibility that Bregs play critical roles in the promotion of transplantation tolerance and that Bregs are the underlying explanation for the B cell signature of tolerance...
January 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28099999/high-level-intrathymic-thyrotrophin-receptor-expression-in-thyroiditis-prone-mice-protects-against-the-spontaneous-generation-of-pathogenic-thyrotrophin-receptor-autoantibodies
#20
S M McLachlan, H A Aliesky, B Banuelos, S Lesage, R Collin, B Rapoport
The thyrotrophin receptor (TSHR) A-subunit is the autoantigen targeted by pathogenic autoantibodies that cause Graves' hyperthyroidism, a common autoimmune disease in humans. Previously, we reported that pathogenic TSHR antibodies develop spontaneously in thyroiditis-susceptible non-obese diabetic (NOD).H2(h4) mice bearing a human TSHR A-subunit transgene, which is expressed at low levels in both the thyroid and thymus (Lo-expressor transgene). The present study tested recent evidence that high intrathymic TSHR expression protects against the development of pathogenic TSHR antibodies in humans...
January 18, 2017: Clinical and Experimental Immunology
journal
journal
21428
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"