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Clinical and Experimental Immunology

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https://www.readbyqxmd.com/read/28090641/in-vivo-quantitative-assessment-of-the-therapeutic-response-in-a-mouse-model-of-collagen-induced-arthritis-using-18-f-fluorodeoxyglucose-positron-emission-tomography
#1
Anupam Mitra, Smriti Kundu-Raychaudhuri, Christine Abria, Angelica Rona, Abhijit J Chaudhari, Siba P Raychaudhuri
BACKGROUND: Mouse collagen induced arthritis (CIA) is the most commonly used animal model to investigate underlying pathogenesis of autoimmune arthritis and to demonstrate therapeutic efficacy of novel drugs in autoimmune arthritis. The conventional read out of CIA are clinical score and histopathology, which have several limitations including (i) subjected to observer bias; (ii) longitudinal therapeutic efficacy of a new drug cannot be determined. Thus a robust, non-invasive, in vivo drug screening tool is currently an unmet need...
January 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28078662/low-immunoglobulin-e-flags-two-distinct-types-of-immune-dysregulation
#2
M Elkuch, V Greiff, C T Berger, M Bouchenaki, T Daikeler, A Bircher, A A Navarini, I Heijnen, M Recher
During the last two decades, hyper-immunoglobulin (Ig)E syndromes have been characterized clinically and molecularly in patients with genetically determined primary immunodeficiencies. However, the detection of low IgE levels, defined here as below detection limit in the routine clinical immunology laboratory, has received little attention. We analysed the association of serum IgA, IgM and IgG levels (including IgG subclasses) with low, normal or high serum IgE levels in patients evaluated in a single-centre out-patient immunodeficiency and allergy clinic...
January 11, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28076879/igm-antibodies-to-proteinase-3-in-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#3
J M Clain, A M Hummel, J H Stone, F C Fervenza, G S Hoffman, C G M Kallenberg, C A Langford, W J McCune, P A Merkel, P A Monach, P Seo, R F Spiera, E W St Clair, S R Ytterberg, And U Specks
Antineutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). Yet, ANCA alone are not sufficient to generate disease, and some evidence suggests that infectious triggers may serve as inciting events for AAV disease activity. Antibodies of the IgM isotype often serve as markers of recent infection, and IgM ANCA have previously been identified in patients with AAV, though the frequency and clinical relevance of IgM ANCA is not well established...
January 11, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28063160/elevated-semaphorin5a-in-systemic-lupus-erythematosus-is-in-association-with-disease-activity-and-lupus-nephritis
#4
Yan Du, Xinyu Wu, Mo Chen, Wenwen Wang, Weihong Xv, Lv Ye, Di Wu, Jing Xue, Wenjia Sun, Judong Luo, Huaxiang Wu
OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response including over-activation of T and B cells development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex, and the abnormal elevation of type I interferon. Semaphorin5A (Sema5A), is essentially involved in immune cell regulation and also implicated in the pathogenesis of autoimmune disorders. We aimed to evaluate the role of Sema5A in patients with SLE...
January 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28054352/impact-of-il13-genetic-polymorphism-arg130gln-on-total-serum-ige-levels-and-ifn-%C3%AE-gene-expression
#5
Bozena Smolkova, Jana Tulinska, Lubica Palkovicova Murinova, Verona Buocikova, Aurelia Liskova, Katarina Rausova, Miroslava Kuricova, Henrieta Patayova, Maria Sustrova, Eva Neubauerova Svorcova, Silvia Ilavska, Michaela Szabova, Tomas Nemessanyi, Eva Jahnova, Maria Dusinska, Peter Ciznar, Laurence Fuortes
This cross-sectional study was designed to investigate the extent of genetic susceptibility by targeting variants in IL-4/IL-13 signalling pathways leading to atopic disease in early childhood. We evaluated involvement of five single nucleotide polymorphisms IL4 C-590T, IL13 C-1055T, IL13 Arg130Gln, IL4RA Ile50Val and IL4RA Ser478Pro, in the control of serum total and antigen-specific IgE levels. Furthermore, we analyzed their association with changes in gene expression of five cytokines having key roles in inflammatory and anti-inflammatory immune response (IL-4, IL-13, IFN-γ, IL-8 and IL-10)...
January 5, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28052400/programmed-death-1-ligand-1-and-2-expression-in-cutaneous-squamous-cell-carcinoma-and-their-relationship-with-tumor-infiltrating-dendritic-cells
#6
Qingqing Jiao, Cuiping Liu, Wenzhong Li, Wei Li, Fuming Fang, Qihong Qian, Xueguang Zhang
The Programmed Death-1 (PD-1) receptor ligands, PD-L1 and PD-L2, are costimulatory molecules that contribute to the negative regulation of T-lymphocyte activation. It is still unclear whether there is correlation between PD-L1 or PD-L2 and tumor infiltrating dendritic cells (TIDCs) in cutaneous squamous cell carcinoma (CSCC). The aim of this study was to analyze PD-L1 and PD-L2 expression and dendritic cells (DCs) infiltration in tumor tissue of CSCC patients and investigate their clinical significance. Immunohistochemical analysis was used to evaluate the expression of PD-L1, PD-L2, CD1a, and CD83 in 61 CSCC tissues...
January 3, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28052346/properdin-deficiency-protects-from-5-fluorouracil-induced-small-intestinal-mucositis-in-a-complement-activation-independent-il-10-dependent-mechanism
#7
Umang Jain, Craig A Midgen, Trent M Woodruff, Wilhelm J Schwaeble, Cordula M Stover, Andrew W Stadnyk
Intestinal mucositis is a serious complication of chemotherapy that leads to significant morbidity that may require dose or drug adjustments. Specific mitigating strategies for mucositis are unavailable, partly due to an incomplete understanding of the pathogenic mechanisms. We have previously shown an effect of properdin, a positive regulator of complement activation, in models of colitis. Here we use properdin deficient (P(KO) ) mice to interrogate the role of properdin and complement in small intestinal mucositis...
January 3, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28035684/homeostatic-migration-and-distribution-of-innate-immune-cells-in-primary-and-secondary-lymphoid-organs-with-aging
#8
REVIEW
Janko Nikolich-Žugich, John S Davies
Aging of the innate and adaptive immune system, collectively termed immune senescence, is a complex process. One method to understand the components of aging involves dissociating the effects of aging on the cells of the immune system, on the microenvironment in lymphoid organs and tissues where immune cells reside, and on the circulating factors that interact with both immune cells and their microenvironment. Heterochronic parabiosis, a surgical union of two organisms of disparate ages, is ideal for this type of studies, as it has the power to dissociate the age of the cell and the age of the microenvironment in which the cell resides or is migrating into...
December 30, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28033681/high-endothelial-venules-associated-with-t-cell-subsets-in-the-inflamed-gut-of-newly-diagnosed-inflammatory-bowel-disease-patients
#9
Carmen S Horjus Talabur Horje, Carolijn Smids, Jos W R Meijer, Marcel J Groenen, Maaike K Rijnders, Ellen G van Lochem, Peter J Wahab
BACKGROUND: Naive and central memory T lymphocytes (TN and TCM ) can infiltrate the inflamed gut mucosa in Inflammatory Bowel Disease (IBD) patients. Homing of these subsets to the gut might be explained by ectopic formation of tertiary lymphoid organs (TLOs), containing high endothelial venules (HEVs). We aimed to evaluate the presence of HEVs and TLOs in inflamed intestinal mucosa of newly diagnosed, untreated, IBD patients in relation to the presence of TN and TCM lymphocytes. METHODS: IBD patients (n=39) and healthy controls (n=8) were prospectively included...
December 29, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28033649/thrombospondin-derived-peptide-attenuates-sj%C3%A3-gren-s-syndrome-associated-ocular-surface-inflammation-in-mice
#10
Laura Contreras-Ruiz, Fayaz A Mir, Bruce Turpie, Sharmila Masli
Sjögren's syndrome is a second most common rheumatic disease in which autoimmune response targets exocrine glands (salivary and lacrimal glands) resulting in clinical symptoms of dry mouth and dry eye. Inflammation of the lacrimal gland induces tear abnormalities that contribute to the inflammation of the ocular surface, which includes ocular mucosa. Thrombospondin-1 (TSP-1) plays a critical regulatory role in the ocular mucosa and as such TSP-1-/- mice spontaneously develop chronic ocular surface inflammation associated with Sjögren's syndrome (SS)...
December 29, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28019655/tumor-activated-liver-stromal-cells-regulate-myeloid-derived-suppressor-cells-accumulation-in-the-liver
#11
Henghui Zhang, Gaixia He, Yaxian Kong, Yanhui Chen, Beibei Wang, Xiuyun Sun, Bei Jia, Xingwang Xie, Xueyan Wang, Dongwei Chen, Lai Wei, Minghui Zhang, Hui Zeng, Hongsong Chen
Regulating mechanisms underlying hepatic myeloid-derived suppressor cells (MDSCs) accumulation remain to be described. Here, we provide evidence for the involvement of tumor-activated liver stromal cells in the process of hepatic MDSCs migration and accumulation. Our data showed elevated frequency of MDSCs in the liver of tumor-bearing mice. Moreover, tumor-activated liver stromal cells promote MDSCs migration into the liver site. Further investigation indicated higher levels of cytokines and chemokines expression in liver stromal cells after exposure to the tumor-conditioned supernatant...
December 26, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28009047/longitudinal-monitoring-of-gene-expression-in-ultra-low-volume-blood-samples-self-collected-at-home
#12
Cate Speake, Elizabeth Whalen, Vivian H Gersuk, Damien Chaussabel, Jared M Odegard, Carla J Greenbaum
Blood transcriptional profiles could serve as biomarkers of clinical changes in subjects at-risk for or diagnosed with diabetes. However, transcriptional variation over time is poorly understood due to the impracticality of frequent longitudinal phlebotomy in large patient cohorts. We have developed a novel transcriptome assessment method that could be applied to fingerstick blood samples self-collected by study volunteers. 15 μL of blood from a fingerstick yielded sufficient RNA to analyze >176 transcripts by high-throughput quantitative PCR...
December 23, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28000208/when-to-initiate-immunoglobulin-replacement-therapy-igrt-in-antibody-deficiency-a-practical-approach
#13
REVIEW
Stephen Jolles, Helen Chapel, Jiri Litzman
Primary antibody deficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) and immunoglobulin replacement forms the mainstay of therapy for many patients in this category. Secondary antibody deficiencies (SAD) represents a larger and expanding number of patients resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal or gastrointestinal immunoglobulin losses. While there are clear similarities between primary and secondary antibody deficiencies, there are also significant differences...
December 21, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936517/-novel-biomarkers-for-the-assessment-of-pediatric-systemic-lupus-erythematosus-nephritis
#14
Artemis Koutsonikoli, Maria Trachana, Evangelia Farmaki, Vasiliki Tzimouli, Polyxeni Pratsidou-Gertsi, Nikoleta Printza, Alexandros Garyphallos, Vasiliki Galanopoulou, Florence Kanakoudi-Tsakalidou, Fotios Papachristou
OBJECTIVES: The discovery of serum biomarkers specific for pediatric Lupus Nephritis (pLN) will facilitate the non-invasive diagnosis, follow-up and more appropriate use of treatment. The aim of this study was to explore the role of serum High-Mobility-Group-Box-1 (HMGB1) protein, antibodies against nucleosomes (anti-NCS), complement factor C1q (anti-C1q) and glomerular basement membrane (anti-GBM) in pLN. METHODS: Serum samples of 42 patients with pediatric Systemic Lupus Erythematosus (pSLE) (22 with pLN and 20 without renal involvement), fifteen patients with other autoimmune nephritis (AN) and 26 healthy controls (HCs) were examined using ELISA...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936514/comparing-acquired-angioedema-with-hereditary-angioedema-type-i-ii-findings-from-the-icatibant-outcome-survey
#15
Hilary J Longhurst, Andrea Zanichelli, Teresa Caballero, Laurence Bouillet, Werner Aberer, Marcus Maurer, Olivier Fain, Vincent Fabien, Irmgard Andresen
Icatibant is approved for hereditary angioedema with C1 inhibitor deficiency type I/II (C1-INH-HAE type I/II) and has shown promise in treatment of angioedema due to acquired C1 inhibitor deficiency (C1-INH-AAE). Data from the Icatibant Outcome Survey was analyzed to evaluate effectiveness of icatibant in the treatment of patients with C1-INH-AAE and compare disease characteristics with those with C1-INH-HAE type I/II. Key medical history (including prior occurrence of attacks) was recorded upon IOS enrollment...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936497/pro-inflammatory-cytokine-ifn%C3%AE-and-microbiome-derived-metabolites-dictate-epigenetic-switch-between-foxp3-isoforms-in-celiac-disease-regulation-of-foxp3-isoforms-in-celiac-disease
#16
Gloria Serena, Shu Yan, Stephanie Camhi, Shilpi Patel, Rosiane S Lima, Anna Sapone, Maureen M Leonard, Rupa Mukherjee, Barbara J Nath, Karen M Lammers, Alessio Fasano
Celiac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong Th1/Th17 immune response in the small intestine. Treg cells are CD4(+) CD25(++) FOXP3(+) cells that regulate the immune response. Conversely to its counterpart, FOXP3 full length (FL), the alternatively spliced isoform FOXP3 Δ2 cannot properly down-regulate Th17 driven immune response. Since the active state of CD has been associated with impairments in Treg cell function, we aimed at determining whether imbalances between FOXP3 isoforms may be associated with the disease...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936495/t-bet-overexpression-regulates-ahr-mediated-th-17-differentiation-through-an-ifn%C3%AE-independent-pathway
#17
Masahiro Yokosawa, Yuya Kondo, Masahiro Tahara, Mana Iizuka-Koga, Seiji Segawa, Shunta Kaneko, Hiroto Tsuboi, Keigyou Yoh, Satoru Takahash, Isao Matsumoto, Takayuki Sumida
Various transcription factors are also known to enhance or suppress Th-17 differentiation. We previously showed that the development of collagen-induced arthritis was suppressed in T-bet transgenic (T-bet Tg) mice and T-bet seemed to suppress Th-17 differentiation through an IFNγ-independent pathway, although the precise mechanism remains to be clarified. The present study was designed to further investigate the mechanisms involved in the regulation of Th-17 differentiation by T-bet overexpression, and we found the new relation between T-bet and aryl hydrocarbon receptor (AHR)...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27936488/ro52-trim21-deficient-expression-and-function-in-different-subsets-of-peripheral-blood-mononuclear-cells-is-associated-with-a-pro-inflammatory-cytokine-response-in-patients-with-idiopathic-inflammatory-myopathies
#18
D Gómez-Martín, A S Galindo-Feria, A Barrera-Vargas, J Merayo-Chalico, G Juárez-Vega, J Torres-Ruiz, J Alcocer-Varela
The presence of anti-Ro52/Trim21 autoantibodies has been associated with a distinctive clinical profile and has gained value as a prognostic marker in idiopathic inflammatory myopathies (IIM). The aim of the present work was to analyze Ro52/Trim21 expression in different subsets of peripheral blood mononuclear cells (PBMCs) of patients with IIM, as well as the ubiquitination profile and its association with pro-inflammatory cytokine production. We included 18 patients with recent onset IIM and 18 age and gender-matched healthy donors...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27925159/lectin-complement-pathway-proteins-in-healthy-individuals
#19
Anne Troldborg, Annette Hansen, Søren W K Hansen, Jens Christian Jensenius, Kristian Stengaard-Pedersen, Steffen Thiel
Since the discovery of the lectin pathway of complement activation, numerous clinical cohorts have been examined for one or more of the proteins, with the intention of uncovering the functions of the proteins or with the aim of discovering new biomarkers or diagnostic tools. To unveil the abnormal, it is pivotal to know the normal. Our aim was to describe the concentrations of the eleven known proteins of the lectin pathway in serum and plasma and to uncover possible gender differences, age and diurnal variations, which must be taken into account for investigations in different cohorts...
December 7, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27891589/critical-roles-of-conventional-dendritic-cells-in-promoting-t-cell-dependent-hepatitis-through-regulating-nkt-cells
#20
Jingya Wang, Xueting Cao, Jiliang Zhao, Huiyuan Zhao, Jun Wei, Qiuying Li, Xiaofei Qi, Zishan Yang, Li Wang, Hongru Zhang, Li Bai, Zhenzhou Wu, Liqing Zhao, Zhangyong Hong, Zhinan Yin
Dendritic cells (DC) play critical roles in initiating and regulating the innate immunity as well as the adaptive immune responses. However, the role of conventional dendritic cells (cDC) in Con A-induced fulminant hepatitis is unknown. In this study, we demonstrated that depletion of cDC using either CD11c-DTR Tg mice or anti-CD11c antibody significantly reduced the severity of liver injury, indicating a detrimental role of cDC in Con A-induced hepatitis. We further elucidated the pathological role of cDC through being the critical source of IL-12, which induced the secretion of IFN-γ by NKT cells...
November 28, 2016: Clinical and Experimental Immunology
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