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Journal of Periodontal Research

Amália Machado Bielemann, Raissa Micaella Marcello-Machado, Alessandra Julie Schuster, Otacílio Luiz Chagas Júnior, Altair Antoninha Del Bel Cury, Fernanda Faot
BACKGROUND: Biological responses to different loading protocols during the bone healing phase in subjects with long time since edentulism, rehabilitated with narrow diameter implants (NDIs) to retain mandibular overdentures (MOs), are still unavailable. OBJECTIVE: This randomized clinical trial compared the peri-implant health, implant stability, and concentrations of pro- and anti-inflammatory cytokines in the peri-implant crevicular fluid (PICF) in mandibular edentulous patients under conventional (CL) and immediate loading (IML) during healing...
November 19, 2018: Journal of Periodontal Research
Jianjia Li, Runting Wang, Yihong Ge, Danhong Chen, Buling Wu, Fuchun Fang
BACKGROUND AND OBJECTIVE: This study aimed to discover the distinctive MicroRNAs (miRNA) functioning in the pathogenesis of periodontal inflammation, which might be potential therapy targets of chronic periodontitis. MATERIAL AND METHODS: miRNA profiles of human inflamed gingival tissue from three previous microarrays were re-analysed. Gingival tissues were collected for the validation of overlapping miRNAs, and a network was constructed to show regulatory connection between overlapping miRNAs and periodontitis-associated target genes...
November 18, 2018: Journal of Periodontal Research
Norio Aoyama, Naho Kobayashi, Tomoya Hanatani, Norihiko Ashigaki, Asuka Yoshida, Yuka Shiheido, Hiroki Sato, Chisato Takamura, Shunji Yoshikawa, Katsuhiko Matsuo, Yuichi Izumi, Mitsuaki Isobe
OBJECTIVE: The aim of this clinical trial was to assess the relationship between periodontal bacterial burden and coronary heart disease (CHD) in Japanese population. BACKGROUND: Many epidemiological reports suggest that periodontitis is a risk factor for CHD; however, the influence of each periodontal bacterium and periodontal condition in Japanese CHD patients is unclear. METHODS: We studied 897 patients with cardiovascular diseases in Tokyo Medical and Dental University Hospital from May 2012 to August 2015...
November 18, 2018: Journal of Periodontal Research
Poliana Mendes Duarte, Letícia de Lorenzo Abreu, André Vilela, Magda Feres, Gabriela Giro, Tamires Szeremeske Miranda
BACKGROUND AND OBJECTIVE: Little is known about the correspondence of cytokines detected among the different biological matrices used in periodontal research and whether locally-detected cytokine mRNA can also be identified at the translated protein level. The aims of this study were to compare: (a) the detection of classic cytokines at protein level in corresponding samples of serum, gingival tissue and gingival crevicular fluid (GCF) in subjects with periodontitis and (b) the detection of cytokines at protein level in GCF and tissue with their detection at mRNA level in tissue...
October 26, 2018: Journal of Periodontal Research
Gabriella Peñarrieta-Juanito, Mariane B Sordi, Bruno Henriques, Marta E R Dotto, Wim Teughels, Filipe S Silva, Ricardo S Magini, Júlio C M Souza
OBJECTIVE: The aim of this study was to evaluate surface changes on dental implant systems and ions release after immersion in fluoride and hydrogen peroxide. METHODS: Ten implant-abutment assemblies were embedded in acrylic resin and cross-sectioned along the implant vertical axis. Samples were wet ground and polished. Delimited areas of groups of samples were immersed in 1.23% sodium fluoride gel (F) or in 35% hydrogen peroxide (HP) for 16 min. Gels (n = 3) were collected from the implant surfaces and analyzed by inductively coupled plasma mass spectrometry (ICP-MS), to detect the concentration of metallic ions released from the implant systems...
October 22, 2018: Journal of Periodontal Research
Mônica Grazieli Corrêa, Samir Absy, Howard Tenenbaum, Fernanda Vieira Ribeiro, Fabiano Ribeiro Cirano, Marcio Z Casati, Suzana Peres Pimentel
OBJECTIVES: This study aimed at investigating the effect of the systemic administration of resveratrol (RESV) on oxidative stress during experimental periodontitis in rats subjected to cigarette smoke inhalation. MATERIAL AND METHODS: Experimental periodontitis (EP) was induced in 26 male Wistar rats by the insertion of a ligature around one of the first mandibular and maxillary molars. The animals were assigned randomly to the following groups: cigarette smoke inhalation (CSI; 3 times/d, 8 minutes/d) + resveratrol (10 mg/Kg), that is, SMK + RESV (n = 13) and cigarette smoke inhalation + placebo, that is, SMK + PLAC (n = 13)...
October 22, 2018: Journal of Periodontal Research
Yakun Han, Ying Jin, Yibin Miao, Tie Shi, Xiaoping Lin
BACKGROUND AND OBJECTIVE: Periodontitis is a bacteria-induced disease that often leads to alveolar bone damage. Its mechanisms were considered to be complicated, involving an imbalance of the formation and resorption of bone. We sought to disclose the antibody-independent function of B cells during periodontitis. MATERIAL AND METHODS: Production of receptor activator for nuclear factor-κB ligand (RANKL) by total lymphocytes or sorted B-cell subsets in gingiva from healthy or experimental periodontitis animals was examined by flow cytometry, real-time polymerase chain reaction, and enzyme-linked immunosorbent assay...
October 22, 2018: Journal of Periodontal Research
Masanori Iwasaki, Yumi Kimura, Hiroshi Ogawa, Takayuki Yamaga, Toshihiro Ansai, Taizo Wada, Ryota Sakamoto, Yasuko Ishimoto, Michiko Fujisawa, Kiyohito Okumiya, Hideo Miyazaki, Kozo Matsubayashi
BACKGROUND AND OBJECTIVES: Identification of modifiable factors for mild cognitive impairment (MCI) is important since individuals with MCI are at a high risk of dementia and disability. Previous studies have suggested a potential association between periodontitis and cognitive impairment, but the results remain inconclusive. We designed a 5-year longitudinal study to explore the association between MCI and periodontitis and periodontal inflammation in older adults. METHODS: This study included 179 community-dwelling dentate individuals (62 men and 117 women, average age: 80...
October 21, 2018: Journal of Periodontal Research
S Ghotloo, H Motedayyen, D Amani, M Saffari, M Sattari
BACKGROUND AND OBJECTIVE: MicroRNA-146a (miR-146a) is a small noncoding RNA that plays a critical role in the negative regulation of the innate immune response, and the dysregulation of miR-146a has been associated with several inflammatory disorders. In generalized aggressive periodontitis (GAgP) the degree of clinical inflammation appears to be similar to that of chronic periodontitis, and, in this situation, age of onset and family history are important additional criteria for diagnosis...
October 17, 2018: Journal of Periodontal Research
Risa Masumoto, Jirouta Kitagaki, Chiharu Fujihara, Masahiro Matsumoto, Shizuka Miyauchi, Yoshihiro Asano, Atsuko Imai, Kaori Kobayashi, Akihiro Nakaya, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case-control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. To overcome this kind of issue, an unbiased GWAS strategy was introduced to identify genetic risk factors for various diseases...
October 10, 2018: Journal of Periodontal Research
Antonio Magán-Fernández, Francisco O'Valle, Francisco Abadía-Molina, Ricardo Muñoz, Patricia Puga-Guil, Francisco Mesa
BACKGROUND AND OBJECTIVE: Neutrophil extracellular traps (NETs) are a recently discovered antimicrobial mechanism used by neutrophils that have been proposed as an intervention in the pathogenesis of periodontitis. The objective of our study was to characterize the expression of NETs in gingival tissues with periodontitis and controls and to compare the expression of these traps in gingival tissue samples of patients with gingivitis and periodontitis. MATERIAL AND METHODS: An observational cross-sectional study was conducted on patients with periodontitis, gingivitis, and controls that needed tooth extraction...
October 8, 2018: Journal of Periodontal Research
Xijiao Yu, Hongmei Liu, Shuang Liu, Xue Chen, Xinyu Zhao, Yi Du, Shu Li
BACKGROUND AND OBJECTIVE: Periodontal ligament-associated protein-1 (PLAP-1) is an important regulator of osteogenic differentiation of periodontal ligament cells and plays important role in the homeostasis of periodontal tissues. But the role of PLAP-1 in periodontitis is poorly understood. Expressions of PLAP-1 in experimental periodontitis are observed to elucidate whether PLAP-1 gets involved in the pathogenesis of periodontitis. MATERIAL AND METHODS: Wistar rats were randomly allocated to two groups (n = 6/group): Ligation group and Control group...
October 8, 2018: Journal of Periodontal Research
Hesham El-Sharkawy, Samah Elmeadawy, Una Elshinnawi, Mohamed Anees
BACKGROUND AND OBJECTIVE: Melatonin is synthesized naturally by pineal gland and responsible for regulation of sleep/waking cycle. It showed appreciated anti-inflammatory and antioxidant properties. The aim of this randomized clinical trial (RCT) was to assess the additive effect of melatonin supplementation in insomniac individuals with generalized chronic periodontitis (gCP) after scaling and root planing (SRP). MATERIAL AND METHODS: Seventy-four gCP patients with primary insomnia participated in this 6-month RCT and randomized into two groups...
October 8, 2018: Journal of Periodontal Research
Na-Young Han, Ji-Youn Hong, Jong-Moon Park, Changsik Shin, Saya Lee, Hookeun Lee, Jeong-Ho Yun
BACKGROUND AND OBJECTIVES: Proteome analysis of periodontal ligament stem cells (PDLSCs) could be used to study the function of PDL tissue. We used a label-free quantitative proteomic technique to investigate differentially expressed proteins (DEPs) in human PDLSCs (hPDLSCs) compared to human bone marrow mesenchymal stem cells (hBMSCs) and identify proteins specific to hPDLSCs. MATERIAL AND METHODS: hPDLSCs (n = 3) and hBMSCs (n = 3) were cultured and harvested for protein extraction and trypsin digestion...
October 8, 2018: Journal of Periodontal Research
Keitetsu Kure, Hiroki Sato, Jun-Ichi Suzuki, Akiko Itai, Norio Aoyama, Yuichi Izumi
BACKGROUNDS AND OBJECTIVES: IMD-0354 is a novel I kappa-B kinase (IKK) inhibitor, which regulates inflammation. The purpose of this study was to examine the effect of the reagent on bone loss for ligature-induced periodontitis. MATERIAL AND METHODS: We ligated around the upper right second molars of 8-week-old C57BL/6J mice in the split-mouth model. The test mice were injected intraperitoneally with IMD-0354 before the placement of the ligature. The control mice were injected intraperitoneally with 0...
October 8, 2018: Journal of Periodontal Research
Karim M Fawzy El-Sayed, Maryam Elahmady, Zeina Adawi, Nour Aboushadi, Ali Elnaggar, Maryam Eid, Nayera Hamdy, Dalia Sanaa, Christof E Dörfer
Adult multipotent stem/progenitor cells, with remarkable regenerative potential, have been isolated from various components of the human periodontium. These multipotent stem/progenitor cells include the periodontal ligament stem/progenitor cells (PDLSCs), stem cells from the apical papilla (SCAP), the gingival mesenchymal stem/progenitor cells (G-MSCs), and the alveolar bone proper stem/progenitor cells (AB-MSCs). Whereas inflammation is regarded as the reason for tissue damage, it also remains a fundamental step of any early healing process...
October 8, 2018: Journal of Periodontal Research
Martina Elenkova, David A Tipton, Anastasios Karydis, Sidney H Stein
BACKGROUND AND OBJECTIVES: Vitamin D [1,25(OH)2 D3 or 1,25D3] is critical in musculoskeletal health, inflammation, immune response, and glucose metabolism. Patients with vitamin D deficiency may be at higher risk of diabetes and periodontitis. Diabetic patients exhibit exacerbated inflammation and more periodontal destruction. Advanced glycation end products (AGEs), formed during diabetic hyperglycemia, activate inflammatory pathways in periodontitis. Human gingival fibroblasts (HGFs) express receptors for AGEs (RAGEs) and can contribute to inflammation...
October 8, 2018: Journal of Periodontal Research
Zheng Zhang, Youli Zheng, Xinyue Li
The purpose of the meta-analysis was to investigate the potential association of interleukin-10 (IL-10) polymorphisms with susceptibility to chronic periodontitis (CP). A total of 33 studies involving 3487 cases and 4356 controls were identified through a search of multiple electronic databases (last search was updated on 19 July 2018). Three single nucleotide polymorphisms (SNPs) were included in the meta-analysis: -1082A>G(rs1800896), -819C>T(rs1800871), and -592C>A(rs1800872). Odds ratios (ORs) and their 95% confidence intervals (CIs) using allele, dominant, and recessive genetic models were computed to assess the strength of the association...
October 8, 2018: Journal of Periodontal Research
Emmanuel Albuquerque-Souza, Danilo Balzarini, Ellen S Ando-Suguimoto, Karin H Ishikawa, Maria R L Simionato, Marinella Holzhausen, Marcia P A Mayer
BACKGROUND AND OBJECTIVE: Although previous studies revealed the potential use of probiotics in the control of periodontitis, little is known about their interactions with gingival epithelial cells (GECs). Since GECs comprise the first defense in the subgingival microenvironment, the aim of this study was to evaluate the effect of probiotic lactobacilli and bifidobacteria strains on OBA-9 cells challenged with Porphyromonas gingivalis. METHODS: Immortalized human GECs (OBA-9) were challenged with live P...
October 4, 2018: Journal of Periodontal Research
Luisa Zupin, Ronald Moura Rodrigues, Chiara Ottavia Navarra, Lorenzo Bevilacqua, Eulalia Catamo, Roberto Di Lenarda, Paolo Gasparini, Sergio Crovella, Antonietta Robino
BACKGROUND: Periodontitis is a common oral disease caused by host inflammatory response towards bacteria biofilm. The chronic activation of immune response leads to destruction of teeth supporting tissue, bone loss and tooth detachment. Different factors could be involved in the development and severity of the disease; among them the host genetic background should be considered. OBJECTIVES: In our study, we analysed haploblocks in a genomic region within major histocompatibility complex (MHC) locus aimed at disclosing a possible correlation with the risk of periodontal disease in 602 adult subjects from North-East Italy...
October 4, 2018: Journal of Periodontal Research
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