journal
MENU ▼
Read by QxMD icon Read
search

Ceskoslovenská Patologie

journal
https://www.readbyqxmd.com/read/27869450/basal-cell-carcinoma-of-the-skin-with-mixed-histomorphology-a%C3%A2-comparative-study
#1
Vladimír Bartoš, Milada Kullová
Basal cell carcinoma (BCC) of the skin exhibits a very heterogeneous histomorphology, on the basis of which it is classified into several subtypes and variants. In many cases, however, a definite categorization remains difficult, because BCC may consist of more than one histopathological subtype. There are limited data exploring the characteristics of these mixed BCCs, since they have not been specifically analysed. The aim of this study was to estimate the prevalence of BCCs with mixed histomorphology observed in a set of primary BCCs and to compare their clinicopathological features with a single type BCC subgroup...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869449/-diffuse-tenosynovial-giant-cell-tumor-of-the-cervical-spine-destroying-vertebra-c6-a%C3%A2-case-report
#2
Zdeněk Kinkor, Tomáš Svoboda, Petr Grossman, David Bludovský, Filip Heidenreich, Andrej Švec, Iveta Mečiarová
Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869448/clear-cell-sarcoma-of-vulva-a-case-report
#3
Kristýna Němejcová, Pavel Dundr, Ivana Krajsová
We report the case of a 67-year-old female with clear cell sarcoma (CCS) of the vulva. Grossly, the tumor was a partly exophytical vulvar mass, measuring 20 x 15 cm. At the time of presentation, the patient showed metastases to the lung, inguinal and pelvic lymph nodes. Histologically, the tumor consisted of oval or spindle cells with only mild nuclear pleomorphism and rare mitoses (up to 2/10 HPF). The cytoplasm was pale eosinophilic or clear. The tumor cells were arranged in confluent sheets. There were large areas of necrosis and surface ulceration...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869447/-testing-of-mutations-in-brca1-and-brca2-genes-in-tumor-tissues-possibilities-and-limitations
#4
Hana Vošmiková, Aleš Ryška, Kateřina Sieglová, Jan Laco
Development of targeted cancer therapy is accompanied by a search for markers allowing prediction of response to the particular treatment. Recently, the interest is focused, among other neoplasms, also on the therapy of ovarian cancer using new inhibitors of poly (ADP-ribose) polymerase (PARP) proteins, nuclear enzymes involved in the repair of single-stranded DNA breaks. The greatest benefit from the administration of PARP inhibitors have patients with a deleterious or potentially deleterious germ-line or somatic mutation of BRCA1 or BRCA2, two genes responsible for repair of double stranded DNA breaks...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869446/-oncopathological-aspects-of-brca1-and-brca2-genes-inactivation-in-tumors-of-ovary-fallopian-tube-and-pelvic-peritoneum
#5
Petr Škapa, Pavel Dundr
Ovarian carcinoma represents a heterogeneous group of malignant epithelial tumors which could be divided into two fundamental groups: Type I (endometrioid carcinoma, clear cell carcinoma, low grade serous carcinoma, mucinous carcinoma and more rare seromucinous carcinoma and malignant Brenner tumor) and type II (high grade serous carcinoma - HGSC). HGSC is the most frequent ovarian carcinoma which may be etiologically linked to inactivation of tumor suppressor genes BRCA1/2 and TP53 and differs from type I carcinomas by higher aggressiveness, tendency to peritoneal spread and worse prognosis...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869445/-breast-cancer-in-brca1-2-mutation-carriers
#6
Pavel Fabian, Rudolf Nenutil
Inherited mutations in BRCA1 and BRCA2 genes represent the most important cause of hereditary breast cancer. This highly penetrating familial cancer syndrome, including also the onset of ovarian cancer and other malignancies at relatively low age, represents a substantial medical problem. The affected families should be managed actively. When compared to spontaneous tumors, the breast carcinomas in BRCA1 mutation carriers exhibit a relatively different, despite non-specific, phenotype (often triple negative, medullary features) arousing suspicion of hereditary background...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869444/-brca1-and-brca2-pathologists-starting-kit
#7
Petr Škapa
Dysfunction of tumor suppressor genes BRCA1 and BRCA2 is involved in the pathogenesis of malignant tumors, especially breast and ovarian carcinoma. BRCA1/2 genes may be inactivated by germinal and somatic mutations or epigenetic changes. Germinal mutations are responsible for the hereditary breast and ovarian carcinoma syndrome. Defects of BRCA1/2 genes lead to the failure of homologous recombination, the basic mechanism for DNA double strand break repair. The resultant genomic instability is associated with a high risk of malignant transformation of the cell, but it also results in a higher sensitivity of tumors to platinum-based chemotherapeutic compounds which damage DNA structure directly...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526019/-lungs-hassalloid%C3%A2-s-like-bodies-in-children-with-epidermolysis-bullosa-junctionalis-and-bart%C3%A2-s-syndrome
#8
Katarína Adamicová, Tomáš Balhárek, Želmíra Fetisovová, Yvetta Mellová
Epidermolysis bullosa and Bart´s syndrome are fairly accurately documented diseases by histopathology. In the article the authors describe interesting and hitherto undescribed phenomenon in the lungs male infant with epidermolysis bullosa junctionalis and Barts syndrome, who died 17 days after birth and 13 days after surgery for pyloric atresia, on multiorgan failure within basic congenital diseases.Histologically in lung alveoli was found to the massive presence of foamy macrophages and numerous globoid formations resembling morphological and immunohistochemical "Hassall´s" bodies in a thymus of the newborn...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526018/-case-report-diagnosis-under-the-microscope-disseminated-echninococcosis-the-multilocular-form-with-protoscoleces
#9
Tomáš Jůza, Alena Jůzová, Tatiana Gajdošová
Echinococcosis (hydatidosis) is a rare severe tissue parasitosis. In the Czech Republic it is caused by two species of tapeworm: Echinococcus granulosus or Echinococcus multilocularis. The species differ in both their usual hosts during their life cycle as well as in the typical form of lesions in infested tissues. In both cases the liver is the most common primary infested organ.We describe an autopsy case of a massive hepatic parasitic lesion in an 81 year-old man. There were metastatic parasitic cysts in both lungs and the hepatic mass spread per continuitatem in the right adrenal gland...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526017/submucosal-calcifying-fibrous-tumor-of-the-stomach-a-case-report
#10
Magdaléna Štofíková, Boris Rychlý, Jozef Bocko, Dušan Daniš
The calcifying fibrous tumor is a rare benign fibrous tumor which occurs in subcutaneous or deep soft tissues in children and young adults, but also is frequently seen in pleural and intraabdominal locations in older people. Gastric involvement has been only sporadically reported in the literature. We present here our experience with this unusual lesion discovered in a 68-year-old woman. Clinically, the tumor was described as a pendulating, submucosally located mass, in the body of the stomach on a lesser curvature...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526016/observations-of-different-patterns-of-dysplasia-in-barretts-esophagus-a-first-step-to-harmonize-grading
#11
Michael Vieth, Elizabeth A Montgomery, Robert H Riddell
We reviewed a set of cases of early neoplasia (low grade / high grade dysplasia / IEN and mucosal carcinoma) to reach better defined criteria for subtypes of dysplasia/differentiation in the columnar lined (Barretts) esophagus. We discuss criteria that we categorized for recognizing low and high-grade dysplasia and mucosal carcinoma in patterns of neoplasia that we regarded as intestinal, gastric and mixed.
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526015/poorly-differentiated-sinonasal-tract-malignancies-a-review-focusing-on-recently-described-entities
#12
Abbas Agaimy
Sinonasal tract malignancies are uncommon, representing no more than 5% of all head and neck neoplasms. However, in contrast to other head and neck sites, a significant proportion of sinonasal neoplasms tend to display a poorly/ undifferentiated significantly overlapping morphology and a highly aggressive clinical course, despite being of diverse histogenetic and molecular pathogenesis. The wide spectrum of poorly differentiated sinonasal epithelial neoplasms with small "basaloid" blue cell morphology includes basaloid squamous cell carcinoma (both HPV+ and HPV-unrelated), nasopharyngeal-type lymphoepithelial carcinoma (EBV+), small/large cell neuroendocrine carcinoma, esthesioneuroblastoma, poorly differentiated carcinoma of salivary type (myoepithelial carcinoma and solid adenoid cystic carcinoma), NUT midline carcinoma, the recently described SMARCB1-deficient sinonasal carcinoma, sinonasal teratocarcinosarcoma and, as a diagnosis of exclusion, sinonasal undifferentiated carcinoma (SNUC)...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526014/-new-developments-in-molecular-diagnostics-of-carcinomas-of-the-salivary-glands-translocation-carcinomas
#13
Alena Skálová, Petr Šteiner, Tomáš Vaneček
In recent years the discovery of translocations and the fusion oncogenes that they result in has changed the way diagnoses are made in salivary gland pathology. These genetic aberrations are recurrent; and at the very least serve as powerful diagnostic tools in salivary gland tumors diagnosis and classification. They also show promise as prognostic markers and hopefully as targets of therapy. In this review the 4 carcinomas currently known to harbor translocations will be discussed, namely mucoepidermoid carcinoma, adenoid cystic carcinoma, mammary analogue secretory carcinoma, and hyalinizing clear cell carcinoma...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27526013/-hpv-associated-head-and-neck-cancer-update-and-recommendations-for-practice
#14
Marian Švajdler, Jan Laco, Ondrej Ondič, Jana Kašpírková, Roman Mezencev, Michal Michal, Alena Skálová
Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV-OSCC) represents a specific clinical and pathological entity among head and neck cancers with more favorable prognosis than corresponding HPV-negative oropharyngeal squamous cell carcinoma (SCC). HPV-OSCC most commonly displays non-keratinzing SCC histology, although number of cases presented variable morphology. Detection of transcriptionally active HPV in oropharyngeal SCCs is of critical prognostic importance, which even supersedes the importance of their formal pathological grading...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27223592/-meningothelial-hamartoma-of-the-scalp-a%C3%A2-case-report
#15
Mária Gregová, Pavel Dundr
We report the case of a 34-year - old male with meningothelial hamartoma. The patient had a subcutaneous tumor of the scalp, clinically diagnosed as a lipoma. Histologically, the tumor consisted of mature connective tissue elements, adipose tissue, blood vessels and clusters of cuboidal or polygonal cells with scant eosinophilic or amphophilic cytoplasm and regular nuclei. Mitoses were absent. Immunohistochemically, these cells showed diffuse positivity for vimentin, epithelial membrane antigen (EMA) and progesterone receptors...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27223591/-in-process-citation
#16
Ondrej Ondič, Ondřej Hes
No abstract text is available yet for this article.
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27223590/-non-traumatic-arteriovenous-malformation-of-the-spleen-with-fatal-hemorrhage
#17
Silvia Farkašová Iannaccone, Daniel Farkaš, Marián Švajdler Ml, Jana Kaťuchová, Vlasta Vyhnálková, Vladimír Sihotský
From the medical point of view, splenic rupture developed either as a result of traumatic injury or as a result of any type of splenic disease represents a very severe and life-threatening condition. We describe the case of a 65-year old man without any obvious traumatic injury who was hospitalised because of left abdominal pain. Investigations performed at admission to the hospital (RTG, USG) failed to indicate any signs of intraabdominal bleeding. However, the patient died suddenly after 24 hours of hospitalisation...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27223589/-in-process-citation
#18
(no author information available yet)
No abstract text is available yet for this article.
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27223588/-interstitial-lung-diseases-associated-with-smoking
#19
Markéta Nová, Helena Hornychová, Radoslav Matěj
There are many different interstitial lung diseases associated with smoking. This short review describes officially recognized disorders (desquamative interstitial pneumonia, respiratory bronchiolitis and pulmonary Langerhans´cells histiocytosis) and entities with uncertain relationship to smoking, which have recently been published in the literature. Histopathological pictures and differential diagnosis of smoking-related diseases of the lungs are discussed.
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27223587/-differential-diagnosis-of-granulomatous-lung-diseases
#20
Helena Hornychová, Markéta Nová, Radoslav Matěj
Brief review of histopathology of non-tumor pulmonary diseases with nodular or granulomatous morphology. Differential diagnosis of infections, sarcoidosis, vasculitides with a granulomatous component and selected pneumoconioses is presented.
2016: Ceskoslovenská Patologie
journal
journal
21381
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"