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Ceskoslovenská Patologie

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https://www.readbyqxmd.com/read/29227122/-hamartoma-of-mature-cardiac-myocytes-autopsy-case-report
#1
Šárka Hadravská, Magdaléna Dubová, Markéta Miesbauerová, Petr Mukenšnabl, Ondřej Daum, Alois Mádle, Karel Smetana
Hamartoma of mature cardiac myocytes (HMCM) is a rare benign pseudoneoplastic myocardial lesion. We describe a case of 39-year-old Bulgarian woman living in the Czech Republic, who died because of rupture of anterior communicating artery aneurysm, and severe bronchopneumonia. An incidental finding at the autopsy was a whitish unencapsulated and not sharply demarcated tumor of the left ventricle and adjacent area of interventricular septum, which protruded above the plane of section. Microscopically the tumor consisted of various different forms of disorganized hypertrophic mature cardiac myocytes without vacuolization of cytoplasm, focally in a "herringbone" pattern...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29227121/-what%C3%A2-s%C3%A2-new-in-ewing-like-sarcoma-family-soft-tissue-and-bone-sarcomas-with-cic-bcor-rearrangement-review-of-the-literature-and-first-personal-experience
#2
Zdeněk Kinkor, Petr Grossmann, Magdaléna Dubová, David Bludovský, Andrea Černá, Lenka Krsková, Petr Lhoták
The literature is reviewed regarding of a rare molecularly defined group of sarcomas with rearrangement of both CIC and BCOR genes, which were originally placed into the EWSR1wt Ewing-like category. Personal experience with three cases demonstrating difficulties of this issue is added. Both groups of lesions differ not only by age and topography, but also vary in both the prognostic and the predictive parameters. CIC-rearranged tumors are very aggressive and almost never occur in the skeleton; in contrary, the BCOR-rearranged ones are predominantly bone tumors in young males behaving even better than classical Ewing sarcoma...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29227120/-molecular-mechanisms-of-primary-and-secondary-resistance-molecular-genetic-features-and-characteristics-of-kit-pdgfra-non-mutated-gists
#3
Alena Kalfusová, Roman Kodet
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Most of them arise due to activating mutations in KIT (75 - 85 %) or PDGFRA (less than 10 %) genes. Identification of the activating mutations in KIT and PDGFRA genes, which code for receptor tyrosine kinases (RTKs), has improved the outcome of targeted therapy of metastatic, unresectable or recurrent GISTs. Primary and/or secondary resistance represents a significant problem in the targeted therapy by Imatinib mesylate (IM) in patients with GIST...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29227119/-molecular-pathology-of-lung-cancer-in-routine-diagnostic-practice-2017-update
#4
Radoslav Matěj, Zdeněk Rohan, Kristýna Němejcová, Pavel Dundr
The group of non-small cell lung carcinomas includes tumors that are variable at the clinical, histopathological and molecular levels. Advances in the understanding of molecular pathology of lung adenocarcinomas in particular led to changes in their histopathological classification and treatment. Patients diagnosed with lung adenocarcinoma harboring specific mutations benefit from the administration of specific targeted therapy. Analysis of EGFR gene mutations and ALK rearrangement in lung adenocarcinomas are already routinely performed and are closely related to the indication for the administration of tyrosinkinase inhibitors...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937781/-lymph-node-metastasis-of-merkel-cell-carcinoma-without-known-cutaneous-primary-case-report
#5
Arpád Szabó, Igor Richter, Dana Frydrychová, Martina Saláková, Tomáš Jirásek
Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary. In this report we present the case of a 42 year-old man with inguinal lymphadenopathy, histologically consistent with Merkel cell carcinoma. Tumor cells expressed immunohistochemically chromogranin-A, synaptophysin and displayed dot-like positivity for cytokeratin 20...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937780/-isolated-infectious-endocarditis-of-the-pulmonary-valve-a%C3%A2-case-report
#6
Jan Hrudka, Monika Grussmannová, Václav Mandys
Isolated infectious endocarditis of the pulmonary valve is a rare condition and represents 1,5-2% of all cases of infectious endocarditis. We present a case of a 37year-old woman without any relevant medical history. The woman was hospitalized with hallmarks of severe sepsis and bilateral pneumonia; she died several hours after admission with progressive multiorgan failure and disseminated intravascular coagulopathy. Microbiologic examination approved Staphylococcus aureus as the etiological agent. The autopsy showed isolated endocarditis of the pulmonary valve, without any known predisposing factor...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937779/-changes-of-the-who-classification-of-lymphoid-neoplasms-in-the-context-of-the-2016-revision
#7
Tomáš Balhárek, Juraj Marcinek, Lukáš Plank
As a result of increasing knowledge, the validity of any tumour classification could not be unlimited. The aim of this article is to review the most important changes in the WHO classification of lymphoid neoplasms of a non-Hodgkin type that have been announced and published in relation to its revision in 2016. These changes are based on better understanding of pathogenesis and genetics of diseases, refine diagnostic criteria, reflect existence of rare forms and introduce new provisional categories of lymphoid neoplasms...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28937778/-changes-of-the-who-classification-of-myeloid-neoplasms-in-the-context-of-the-2016-revision
#8
Juraj Marcinek, Tomáš Balhárek, Lukáš Plank
Continual progress of knowleges in hematopathology and genetics of hematologic tumors requires actualisation of widely accepted and presently used WHO classification of myeloid neoplasms published 8 years ago. However, the basic principles of this classification remain unchanged, therefore the authors of new WHO classification mention the "revision" of previous and not the introduction o new classification. The aim of this paper is to outline the most important changes of myeloid neoplasm diagnostics to pathologists, hematologists and other clinicians in Czech Republic and Slovakia...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28597671/mature-teratoma-of-the-uterine-corpus-a-case-report
#9
Jan Galko, Pavel Dundr
We report a case of a 37-year old female with a mature teratoma of the uterine corpus presented by metrorrhagia. Grossly, the tumor was polypoid without apparent invasion into the myometrium. Microscopically, the tumor consisted of disorganized mature neural tissue intermingled with nodular foci of cartilaginous tissue, groups of seromucionous glands and ciliated columnar respiratory epithelium. Fifteen months after the diagnosis, the patient showed no signs of tumor relapse. Then she was lost for a follow-up...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28597670/-identification-of-an-optimal-algorithm-for-effective-diagnostics-of-non-small-cell-lung-cancer-with-alk-gene-rearrangement-implementation-of-the-method-and-practical-experiences-with-routine-diagnostics
#10
Tomáš Rozkoš, Aleš Ryška, Markéta Nová, Helena Hornychová, Lukáš Krbal, Radoslav Matěj, Jan Laco
The aim of the retrospective part of the study was a) to select an optimal clone of immunohistochemical (IHC) antibody against the ALK protein with specificity and sensitivity high enough to use this antibody as a screening method for selecting non-small cell lung cancer (NSCLC) cases for fluorescence in situ hybridization (FISH) testing of ALK gene rearrangement and b) to determine the diagnostic yield of "small" biopsies i.e. endobronchial, transbronchial and transthoracic biopsies and cytoblocks for ALK gene rearrangement testing...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28597669/-myxoid-tumors-of-soft-tissues
#11
Karel Veselý
Myxoid tumours of soft tissue represent a heterogeneous spectrum of lesions with variable biological behaviour, from completely benign to highly aggressive malignancies. Myxoid tumours share abundant myxoid extracellular matrix, overlapping histopathologic features and immunohistochemical findings, with resulting diagnostic problems. This review article attempts to give the most complete list possible, with the characterization of gross and microscopic features, relevant immunohistochemical and molecular biology findings and to outline differential diagnosis...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28597668/hybrid-peripheral-nerve-sheath-tumors-a-review
#12
Michael Michal, Dmitry V Kazakov, Michal Michal
Hybrid peripheral nerve sheath tumors (HPNST) are relatively recently described tumors. With ongoing research, a considerable amount of important findings have been made, much of which has substantial clinical implications. However, a comprehensive review of the whole topic has not been published in the literature so far. In the presented manuscript, the various hybrid tumors are discussed separately with a special emphasis on the morphological and immunohistochemical findings as well as on their association with tumor syndromes...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28597667/-giant-cell-rich-lesions-of-bone-and-their-differential-diagnosis
#13
Iva Zambo, Lukáš Pazourek
Giant cell-rich lesions form a heterogeneous group of reactive and truly neoplastic processes with diverse clinical presentation and biological behavior. Common to all of them are variably numerous multinucleated osteoclast-like giant cells and the presence of mononuclear stroma. Based on the histological picture alone it is sometimes impossible to reliably distinguish certain tumors from each other. The pathologist has to know the patient´s age, the exact localization, tumor growth dynamics and its radiographic characteristics...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28248121/-unusual-histopathological-picture-of-acute-lung-injury-in-different-stages-of-resorption-with-predominance-of-organizing-pneumonia-in-a%C3%A2-young-man-with-influenza-a%C3%A2-h1n1
#14
Daniel Farkaš, Radoslav Matěj, Marián Ml Švajdler, Marcela Sluková, Jana Seligová, Lucia Fröhlichová, Silvia Farkašová Iannaccone, Vlasta Vyhnálková, Alžbeta Ginelliová
In this case report the authors describe histomorphological findings of acute lung injury with laboratory-confirmed influenza type A(H1N1) pneumonia leading to the death of a 30 year-old unvaccinated man after 27 days of hospitalisation. Histologically all three types of acute lung injuries were unusually present (diffuse alveolar damage, acute interstitial pneumonia, organizing pneumonia) in different phases of resorption and reparation with transition to extensive fibrosis.
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28248120/sebaceous-adenoma-arising-in-mature-cystic-teratoma-of-the-ovary-case-report
#15
Kristýna Němejcová, Pavel Dundr, Jana Rosmusová, Inna Tučková
We report the case of a 44-year-old female with sebaceous adenoma arising in mature cystic teratoma of the ovary. The patient had a tumor in the left ovary; 125 x 90 x 70 mm. Microscopically, the tumor consisted of structures typical of dermoid cysts. However, large areas of sebaceous proliferation were found. These areas were comprised of sebaceous nodules with features similar to a sebaceous adenoma of the skin. Immunohistochemically, the tumor showed "wild-type" expression of p53 and low proliferative activity (Ki-67 index < 5%)...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28248119/familial-hemophagocytic-lymphohistiocytosis-from-autopsy-to-prenatal-diagnosis-report-of-a%C3%A2-case
#16
Marta Ježová, Renata Gaillyová
Hemophagocytic lymphohistiocytosis is a rare immunologic disorder affecting small children. It is characterized by an excessive and injurious immune response which turns rapidly fatal unless promptly and effectively treated. The main clinical signs are prolonged fever, hepatosplenomegaly, bleeding and laboratory findings of pancytopenia, increased serum transaminases, hypertriglyceridemia and hypofibrinogenemia. Four genes responsible for familiar hemophagocytic lymphohistiocytosis, which is inherited in autosomal recessive manner, have been identified so far...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28248118/-update-on-the-2016-who-classification-of-tumors-of-the-central-nervous-system-part-2-embryonal-tumors-and-other-tumor-groups-except-for-diffuse-gliomas
#17
Josef Zámečník, Boris Rychlý, Marian Švajdler
The 2016 revision of the WHO classification of tumors of the central nervous system is a conceptual advance over the 2007 classification system. Similarly to the group of diffuse gliomas, a significant shift in the understanding of the molecular background and tumor biology has recently occurred also in the category of embryonal CNS tumors, especially in medulloblastomas. The classification now incorporates new entities that are defined by both histology and molecular features. Updates in the group of gliomas (except for diffuse gliomas), in the meningeal tumors as well as in the tumors of peripheral nerve sheaths will also be discussed...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/28248117/-update-on-the-2016-who-classification-of-tumors-of-the-central-nervous-system-part-1-diffusely-infiltrating-gliomas
#18
Marian Švajdler, Boris Rychlý, Josef Zámečník, Peter Švajdler
Revised WHO 2016 classification of tumors of the central nervous system (CNS) incorporates for the first time genetic information in addition to morphology for classification of many tumor entities. One of the most important changes is restructuring the chapter of diffuse gliomas. Based on shared genetic driver mutations, diffusely infiltrating astrocytomas and oligodendrogliomas are now classified together, separately from "other" glial tumors with a more circumscribed growth pattern, different pathogenesis and clinical outcome...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869450/basal-cell-carcinoma-of-the-skin-with-mixed-histomorphology-a%C3%A2-comparative-study
#19
Vladimír Bartoš, Milada Kullová
Basal cell carcinoma (BCC) of the skin exhibits a very heterogeneous histomorphology, on the basis of which it is classified into several subtypes and variants. In many cases, however, a definite categorization remains difficult, because BCC may consist of more than one histopathological subtype. There are limited data exploring the characteristics of these mixed BCCs, since they have not been specifically analysed. The aim of this study was to estimate the prevalence of BCCs with mixed histomorphology observed in a set of primary BCCs and to compare their clinicopathological features with a single type BCC subgroup...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27869449/-diffuse-tenosynovial-giant-cell-tumor-of-the-cervical-spine-destroying-vertebra-c6-a%C3%A2-case-report
#20
Zdeněk Kinkor, Tomáš Svoboda, Petr Grossman, David Bludovský, Filip Heidenreich, Andrej Švec, Iveta Mečiarová
Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone...
2016: Ceskoslovenská Patologie
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