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Circulation Research

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https://www.readbyqxmd.com/read/30030219/c1q-tnf-%C3%AE-related-protein-1-ctrp1-maintains-blood-pressure-under-dehydration-conditions
#1
Sora Han, Ae Lee Jeong, Sunyi Lee, Jeong Su Park, Sumiyasuren Buyanravjikh, Wonku Kang, Seungmok Choi, Changmin Park, Jin Han, Woo-Chan Son, Kyung Hyun Yoo, Jae Hoon Cheong, Goo Taeg Oh, Won-Young Lee, Jongwan Kim, Suk Hyo Suh, Sang-Hak Lee, Jong-Seok Lim, Myeong-Sok Lee, Young Yang
<u>Rationale:</u> Circulating C1q/TNF-α-related protein 1 (CTRP1) levels are increased in hypertensive patients compared to in healthy subjects. Nonetheless, little is known about the molecular and physiological function of CTRP1 in blood pressure (BP) regulation. <u>Objective:</u> To investigate the physiological/pathophysiological role of CTRP1 in BP regulation. <u>Methods and Results:</u> CTRP1 production was increased to maintain normotension under dehydration conditions, and this function was impaired in inducible CTRP1 knockout mice (CTRP1ΔCAG)...
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026254/tho-complex-dependent-posttranscriptional-control-contributes-to-vascular-smooth-muscle-cell-fate-decision
#2
Li Wang, Xinli Yuan, Fang Yao, Tao Zhang, Zongna Ren, Bingying Zhou, Fei Liu, Yingnan Liao, Leng Han, Lixia Diao, Yankui Li, Fan He
<u>Rationale:</u> Modulation of vascular smooth muscle cell (VSMC) phenotype plays a fundamental role in vascular development and diseases. While extensive studies uncovered the roles of transcriptional regulation in VSMC-specific gene expression, how posttranscriptional regulation contributes to VSMC fate decisions remains to be determined. <u>Objective:</u> To establish THO complex-dependent VSMC gene expression as a novel regulatory basis controlling VSMC phenotypes. <u>Methods and Results:</u> Immunohistochemical staining against THOC2 and THOC5, two components of the THO complex, revealed a dramatic reduction in their expression in human arteries undergoing carotid endarterectomy (CEA) compared to normal internal mammary arteries (IMA)...
July 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29986945/large-scale-single-cell-rna-seq-reveals-molecular-signatures-of-heterogeneous-populations-of-human-induced-pluripotent-stem-cell-derived-endothelial-cells
#3
David T Paik, Lei Tian, Jaecheol Lee, Nazish Sayed, Ian Y Chen, Siyeon Rhee, June-Wha Rhee, Youngkyun Kim, Robert C Wirka, Jan W Buikema, Sean M Wu, Kristy Red-Horse, Thomas Quertermous, Joseph C Wu
<u>Rationale:</u> Human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) have risen as a useful tool in cardiovascular research, offering a wide gamut of translational and clinical applications. However, inefficiency of the currently available iPSC-EC differentiation protocol and underlying heterogeneity of derived iPSC-ECs remain as major limitations of iPSC-EC technology. <u>Objective:</u> Here we performed droplet-based single-cell RNA-sequencing (scRNA-seq) of the human iPSCs following iPSC-EC differentiation...
July 9, 2018: Circulation Research
https://www.readbyqxmd.com/read/29980569/imaging-the-vascular-bone-marrow-niche-during-inflammatory-stress
#4
Katrien Vandoorne, David Rohde, Hye-Yeong Kim, Gabriel Courties, Gregory R Wojtkiewicz, Lisa Honold, Friedrich F Hoyer, Vanessa Frodermann, Ribhu Nayar, Fanny E Herisson, Yookyung Jung, Pauline Désogère, Claudio Vinegoni, Peter Caravan, Ralph Weissleder, David E Sosnovik, Charles P Lin, Filip K Swirski, Matthias Nahrendorf
<u>Rationale:</u> Inflammatory stress induced by exposure to bacterial lipopolysaccharide (LPS) causes hematopoietic stem cell (HSC) expansion in the bone marrow niche, generating a cellular immune response. As an integral component of the hematopoietic stem cell niche, the bone marrow vasculature regulates the production and release of blood leukocytes, which protect the host against infection but also fuel inflammatory diseases. <u>Objective:</u> We aimed to develop imaging tools to explore vascular changes in the bone marrow niche during acute inflammation...
July 6, 2018: Circulation Research
https://www.readbyqxmd.com/read/29980568/binding-of-dickkopf-3-to-cxcr7-enhances-vascular-progenitor-cell-migration-and-degradable-graft-regeneration
#5
Shirin Issa Bhaloo, Yifan Wu, Alexandra LE Bras, Baoqi Yu, Wenduo Gu, Yao Xie, Jiacheng Deng, Zhihong Wang, Zhongyi Zhang, Deling Kong, Yanhua Hu, Aijuan Qu, Qiang Zhao, Qingbo Xu
<u>Rationale:</u> Vascular progenitor cells (VPCs) play key roles in physiological and pathological vascular remodelling, a process that is crucial for the regeneration of acellular biodegradable scaffolds engineered as vital strategies against the limited availability of healthy autologous vessels for bypass grafting. Therefore, understanding the mechanisms driving VPCs recruitment and differentiation could help the development of new strategies to improve Tissue-Engineered Vessel Grafts (TEVGs) and design drug-targeted therapy for vessel regeneration...
July 6, 2018: Circulation Research
https://www.readbyqxmd.com/read/29976553/beet-the-best-dietary-inorganic-nitrate-to-augment-exercise-training-in-lower-extremity-peripheral-artery-disease-with-intermittent-claudication
#6
Mary N Woessner, Mitch D VanBruggen, Carl F Pieper, Richard Sloane, William E Kraus, Andrew J Gow, Jason D Allen
<u>Rationale:</u> A primary goal of therapy for patients with peripheral arterial disease and intermittent claudication (PAD+IC) is increased ambulatory function. Supervised exercise rehabilitation was recently shown to confer superior walking benefits to pharmacological or surgical interventions. Increases in plasma inorganic nitrite, via oral nitrate, have been shown to increase exercise performance in both human and animal models, especially in hypoxic conditions. <u>Objective:</u> To determine whether a 36-session exercise rehabilitation program while consuming oral inorganic nitrate (4...
July 5, 2018: Circulation Research
https://www.readbyqxmd.com/read/29970365/matrix-metalloprotease-9-mmp-9-producing-monocytes-enable-t-cells-to-invade-the-vessel-wall-and-cause-vasculitis
#7
Ryu Watanabe, Toshihisa Maeda, Hui Zhang, Gerald J Berry, Markus Zeisbrich, Robert D Brockett, Andrew E Greenstein, Lu Tian, Jörg Goronzy, Cornelia M Weyand
<u>Rationale:</u> Giant cell arteritis (GCA), a primary vasculitis of medium and large arteries, is associated with vessel wall damage, elastic membrane fragmentation and vascular remodeling. Proteinases are believed to contribute to pathogenesis by degrading extracellular matrix and causing tissue injury. <u>Objective:</u> The matrix metalloproteinase 9 (MMP-9), a type IV collagenase, is produced in the vasculitic lesions of GCA. It is unknown which pathogenic processes are MMP-9 dependent...
July 3, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026380/mouse-models-of-cardiac-arrhythmias
#8
Dobromir Dobrev, Xander H T Wehrens
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026379/effective-metabolic-approaches-for-the-energy-starved-failing-heart-bioenergetic-resiliency-via-redundancy-or-something-else
#9
Jianyi Zhang, E Dale Abel
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026378/redox-regulation-beyond-ros-why-ros-should-not-be-measured-as-often
#10
Ralf P Brandes, Flavia Rezende, Katrin Schröder
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026377/leducq-network-modulating-autophagy-to-treat-cardiovascular-disease
#11
Julio Madrigal-Matute, Luca Scorrano, Junichi Sadoshima
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026376/jos%C3%A3-jalife-perseverance-pays-off
#12
Ruth Williams
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026375/david-m-ryba-pushing-the-field-forward
#13
Pam Goldberg-Smith
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026374/softening-the-stressed-giant-titin-in-diabetes-mellitus
#14
EDITORIAL
Mei Methawasin, Henk Granzier
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026373/a-crispr-take-on-clonal-hematopoiesis
#15
EDITORIAL
Filip K Swirski
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/30026372/meet-the-first-authors
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/29930147/cell-specific-functions-of-adam17-regulate-the-progression-of-thoracic-aortic-aneurysm
#17
Mengcheng Shen, Mei Hu, Paul W M Fedak, Gavin Y Oudit, Zamaneh Kassiri
RATIONALE: ADAM17 (a disintegrin and metalloproteinase-17) is a membrane-bound enzyme that regulates bioavailability of multiple transmembrane proteins by proteolytic processing. ADAM17 has been linked to several pathologies, but its role in thoracic aortic aneurysm (TAA) has not been determined. OBJECTIVE: The objective of this study was to explore the cell-specific functions of vascular ADAM17 in the pathogenesis and progression of TAA. METHODS AND RESULTS: In aneurysmal thoracic aorta from patients, ADAM17 was increased in tunica media and intima...
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/29898892/mitochondrial-ros-drive-sudden-cardiac-death-and-chronic-proteome-remodeling-in-heart-failure
#18
Swati Dey, Deeptankar DeMazumder, Agnieszka Sidor, D Brian Foster, Brian O'Rourke
RATIONALE: Despite increasing prevalence and incidence of heart failure (HF), therapeutic options remain limited. In early stages of HF, sudden cardiac death (SCD) from ventricular arrhythmias claims many lives. Reactive oxygen species (ROS) have been implicated in both arrhythmias and contractile dysfunction. However, little is known about how ROS in specific subcellular compartments contribute to HF or SCD pathophysiology. The role of ROS in chronic proteome remodeling has not been explored...
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/29880546/effects-of-repetitive-transendocardial-cd34-cell-transplantation-in-patients-with-nonischemic-dilated-cardiomyopathy
#19
Bojan Vrtovec, Gregor Poglajen, Matjaz Sever, Gregor Zemljic, Sabina Frljak, Andraz Cerar, Marko Cukjati, Martina Jaklic, Peter Cernelc, François Haddad, Joseph C Wu
RATIONALE: Preclinical data in heart failure models suggest that repetitive stem cell therapy may be superior to single-dose cell administration. OBJECTIVE: We investigated whether repetitive administration of CD34+ cells is superior to single-dose administration in patients with nonischemic dilated cardiomyopathy. METHODS AND RESULTS: Of 66 patients with dilated cardiomyopathy, New York Heart Association functional class III, and left ventricular ejection fraction (LVEF) <40% enrolled in the study, 60 were randomly allocated to repetitive cell therapy (group A, n=30) or single-cell therapy (group B, n=30)...
July 20, 2018: Circulation Research
https://www.readbyqxmd.com/read/29760016/diabetes-induced-cardiomyocyte-passive-stiffening-is-caused-by-impaired-insulin-dependent-titin-modification-and-can-be-modulated-by-neuregulin-1
#20
Anna-Eliane Hopf, Christian Andresen, Sebastian Kötter, Małgorzata Isić, Kamila Ulrich, Senem Sahin, Sabine Bongardt, Wilhelm Röll, Felicitas Drove, Nina Scheerer, Leni Vandekerckhove, Gilles W De Keulenaer, Nazha Hamdani, Wolfgang A Linke, Martina Krüger
RATIONALE: Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction associated with type-2 diabetes mellitus. However, the insulin-related signaling pathways that modify titin-based cardiomyocyte tension, thereby contributing to modulation of diastolic function, are largely unknown. OBJECTIVE: We aimed to determine how impaired insulin signaling affects titin expression and phosphorylation and thus increases passive cardiomyocyte tension, and whether metformin or neuregulin-1 (NRG-1) can correct disturbed titin modifications and increased titin-based stiffness...
July 20, 2018: Circulation Research
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