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Experimental Gerontology

S Drevet, G Gavazzi, L Grange, C Dupuy, B Lardy
Osteoarthritis (OA) is a degenerative chronic disease affecting >300,000 million people around the world as of 2016. Symptomatic measures exist, but there are hardly any curative treatments available. Disruption of the cartilage homeostasis in favor of catabolism leads to cartilage destruction. ROS-macromolecular-induced damage is significantly greater in OA cartilage and OA is described as low-grade chronic systemic inflammation. This review aimed to assess the critical role of cartilage ageing and oxidative stress in the OA process, focusing in particular on NADPH oxidase and especially Nox4 involvement...
July 13, 2018: Experimental Gerontology
Kai Yao, Yong-Fei Zhao
As the crucial etiological factor, aging-related microglia activation promotes the development of Parkinson's disease (PD). However, the molecular and functional changes of aged-microglia and their contribution to neurodegeneration in PD are only partially understood, which was investigated in our study. Female C57BL/6 mice were randomly divided into four groups, included young-control group, young-MPTP group, aged-control group and aged-MPTP group. Pole test and adhesive removal test were firstly performed...
July 12, 2018: Experimental Gerontology
Erin B Bruce, Yasemin Sakarya, Nataliya Kirichenko, Hale Z Toklu, Colin Sumners, Drake Morgan, Nihal Tümer, Philip J Scarpace, Christy S Carter
The obesity epidemic is multi-generational and is particularly debilitating in the aging population, necessitating the use of pharmaceutical interventions. Recent evidence suggests that increasing the activity of the angiotensin converting enzyme-2 [ACE2]/angiotensin-(1-7)[Ang-(1-7)]/Mas receptor (MasR) axis in obese animal models leads to significant reductions in body weight. It was hypothesized that activation of ACE2 via diminazene aceturate (DIZE) will significantly reduce body weight of rats fed a high fat diet...
July 11, 2018: Experimental Gerontology
Nare Torosyan, Chakmeedaj Sethanandha, Joshua D Grill, Michelle L Dilley, Jooyeon Lee, Jeffrey L Cummings, Celine Ossinalde, Daniel H Silverman
BACKGROUND: Caprylidene is a ketogen that, when metabolized, produces the ketones beta-hydroxybutyrate and acetoacetate, which can cross the blood brain barrier. It has been hypothesized that ketone bodies can be used as an alternate energy source by neurons with impaired glucose utilization. Caprylidene has been shown to improve cognition in patients with mild-to-moderate Alzheimer's disease (AD) who lacked an AD-predisposing allele (ɛ4) of the gene for apolipoprotein E. In this pilot study, we examined the effects of caprylidene on regional cerebral blood flow (rCBF) in patients with mild to moderate AD...
July 10, 2018: Experimental Gerontology
J K Chhetri, P de Souto Barreto, G Soriano, I Gennero, C Cantet, B Vellas
OBJECTIVE: The aim of this study was to investigate the nutritional markers (Vitamin D, homocysteine, n-3PUFA) status of older subjects aged 70 years and older with subjective memory complaint, according to their physical and cognitive function. MAIN OUTCOME MEASURES: This study is a secondary analysis of the MAPT study. Subjects were classified into four groups: 1) Physical limitation with cognitive impairment (PLCI), 2) cognitive impairment (CI), 3) physical limitation (PL) and 4) no physical or cognitive deficits (NPCD)...
July 10, 2018: Experimental Gerontology
Laxmi Rathor, Rakesh Pandey
Oxidative damage is accrual of molecular deterioration from reactive oxygen species (ROS) while decrease in generation of ROS is related with free radical scavenging enzymes. Boerhaavia diffusa L. (Nyctaginaceae) derived novel molecule Boeravinone B (BOB) possesses a variety of pharmacological activities, yet their anti-aging potential has not been explored. The aim of the present study was to elucidate the mechanism of BOB mediated oxidative stress resistance and lifespan extension in Caenorhabditis elegans...
July 9, 2018: Experimental Gerontology
Liza De Dobbeleer, Olga Theou, Ingo Beyer, Gareth R Jones, Jennifer M Jakobi, Ivan Bautmans
INTRODUCTION: Muscle fatigability can be measured based on sustained handgrip performance, but different grip strength devices exist and their relationship to frailty remains unclear. We aimed to compare muscle fatigability obtained by Martin Vigorimeter and Jamar Dynamometer in older women across levels of frailty. METHOD: 53 community-dwelling women living in Greece (63-100 y), categorized according to tertiles on the Frailty Index score (FI) as: low-frail (FI < 0...
July 9, 2018: Experimental Gerontology
Lingxiao He, Evelien Van Roie, An Bogaerts, Christopher I Morse, Christophe Delecluse, Sabine Verschueren, Martine Thomis
This study aims to identify a genetic predisposition score from a set of candidate gene variants that predicts the response to a one-year exercise intervention. 200 participants (aged 60-83 years) were randomly assigned to a fitness (FIT), whole-body vibration (WBV) and control group. Participants in the exercise (FIT and WBV) groups performed a one-year intervention program. Whole-body skeletal muscle mass (SMM) and isometric knee extension strength (PTIM60 ) were measured before and after the intervention...
July 4, 2018: Experimental Gerontology
Chandramouli Krishnan, Edward P Washabaugh, Courtney E Reid, Matteo M Althoen, Rajiv Ranganathan
Evidence from upper-extremity literature suggests that the normal ageing process affects an individual's ability to learn and retain a motor skill, but spares their ability to transfer the skill to the untrained, opposite limb. While this phenomenon has been well-studied in the upper-extremity, evidence in the lower-extremity is limited. Further, it is unclear to what extent age-related differences in motor learning and transfer are dependent on visual feedback of the motor task. Therefore, the purpose of this study was to examine the effects of ageing on motor learning, retention, and interlimb transfer during walking with and without visual feedback...
July 4, 2018: Experimental Gerontology
Hamizah Shahirah Hamezah, Lina Wati Durani, Daijiro Yanagisawa, Nor Faeizah Ibrahim, Wan Mohd Aizat, Jean Pierre Bellier, Suzana Makpol, Wan Zurinah Wan Ngah, Hanafi Ahmad Damanhuri, Ikuo Tooyama
Decrease in multiple functions occurs in the brain with aging, all of which can contribute to age-related cognitive and locomotor impairments. Brain atrophy specifically in hippocampus, medial prefrontal cortex (mPFC), and striatum, can contribute to this age-associated decline in function. Our recent metabolomics analysis showed age-related changes in these brain regions. To further understand the aging processes, analysis using a proteomics approach was carried out. This study was conducted to identify proteome profiles in the hippocampus, mPFC, and striatum of 14-, 18-, 23-, and 27-month-old rats...
July 4, 2018: Experimental Gerontology
Paulo H S Pelicioni, Matthew A Brodie, Mark D Latt, Jasmine C Menant, Hylton B Menz, Victor S C Fung, Stephen R Lord
INTRODUCTION: People with Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability and gait difficulty (PIGD) subtypes; the latter group having more impaired gait and increased fall risk. While there is some evidence that anti-parkinsonian medication, levodopa, might not improve balance and gait control or reduce fall risk in the PIGD subtype, it is unclear whether the levodopa dosage intake affects gait stability. To address these issues, this study used accelerometry to compare gait stability: (i) during before and after levodopa intake between non-PIGD and PIGD subtypes; (ii) between individuals who took less or >750 mg of levodopa/day...
July 3, 2018: Experimental Gerontology
Russell Ault, Varun Dwivedi, Elisha Koivisto, Jenna Nagy, Karin Miller, Kokila Nagendran, Indu Chalana, Xueliang Pan, Shu-Hua Wang, Joanne Turner
Tuberculosis (TB) is the leading killer due to a single infectious disease worldwide. With the aging of the global population, the case rate and deaths due to TB are highest in the elderly population. While general immunosenescence associated with old age is thought to contribute to the susceptibility of the elderly to develop active TB disease, very few studies of immune function in elderly individuals with Mycobacterium tuberculosis (M.tb) infection or disease have been performed. In particular, impaired adaptive T cell immunity to M...
July 3, 2018: Experimental Gerontology
Katharina Denk, Sheila Lennon, Susan Gordon, Ruurd Lucas Jaarsma
Hip fractures are a global concern, resulting in poor outcomes and high health care costs. They mostly affect people >80 years. Hip fractures are influenced by various (modifiable) risk factors. Emerging evidence suggests hand grip strength (HGS) to be one of several useful tools to identify hip fracture risk. This is the first systematic review that aims to assess the evidence underlying the relationship between hip fracture incidence and HGS. Eleven studies were selected for this review (six case-control and five cohort studies), comprising 21,197 participants...
June 30, 2018: Experimental Gerontology
Ryohei Tsuji, Yuta Komano, Konomi Ohshio, Naoaki Ishii, Osamu Kanauchi
Aging is accompanied by the decline in immune function, resulting in increasing susceptibility to infectious diseases and tumorigenesis. In our previous reports, we showed that Lactococcus lactis subsp. lactis JCM 5805 (LC-Plasma) stimulated plasmacytoid dendritic cells (pDCs), which play an important role in viral infection, and oral administration of LC-Plasma showed prophylactic effects against viral infection both in mice and humans. However, the effects of long-term administration of LC-Plasma are not known...
June 29, 2018: Experimental Gerontology
Shashank Shekhar, Yudhishthir Yadav, Amrendra Pratap Singh, Rashmita Pradhan, Gaurav Rajesh Desai, A B Dey, Sharmistha Dey
The oxidative stress plays a key role in Alzheimer's disease (AD) and Sirtuin (SIRT1) is potential mediator of oxidative pathway. This study explored the role of Syzygium aromaticum on SIRT1 and oxidative balance in amyloid beta induced toxicity. Anti-oxidative capacity of Syzygium aromaticum was performed in Aβ25-35 induced neurotoxicity in neuronal cells. Superoxide dismutase, Catalase and Glutathione enzyme activity were determined by the treatment of Syzygium aromaticum. Both recombinant and endogenous SIRT1 activity were performed in its presence...
June 27, 2018: Experimental Gerontology
Richard A Perry, Lemuel A Brown, Wesley S Haynie, Jacob L Brown, Megan E Rosa-Caldwell, David E Lee, Nicholas P Greene, Tyrone A Washington
Sarcopenic obesity (SO) is the comorbidity of age-related muscle wasting and obesity. SO increases the risk of heart disease, but little is known about the cellular signaling in cardiac muscle of SO individuals. AIM: The purpose of this study was to identify key cellular signaling alterations in cardiac muscle of sarcopenic obese mice. METHODS: Thirty-two, male C57BL/6J mice were randomly divided into lean and high-fat fed groups and raised to 3-4 months (young) or 20-22 months (aged) of age...
June 26, 2018: Experimental Gerontology
Jessica Salles Henrique, Erivelton Fernandes França, Fabrizio Dos Santos Cardoso, Fernando Tadeu Serra, Alexandre Aparecido de Almeida, Jansen Fernandes, Ricardo Mario Arida, Sérgio Gomes da Silva
Aging is often accompanied by an increase in pro-inflammatory markers. This inflammatory process is directly related to cellular dysfunctions that induce events such as the exacerbated activation of cell death signaling pathways. In the aged brain, dysregulation of the normal activities of neuronal cells compromises brain functions, thereby favoring the onset of neurodegenerative diseases and cognitive deficits. Interactions between various stimuli, such as stress, are responsible for the modulation of cellular processes and activities...
June 26, 2018: Experimental Gerontology
Dmytro S Krasnienkov, Mykola D Khalangot, Victor I Kravchenko, Volodymyr A Kovtun, Vitaly G Guryanov, Valentina P Chizhova, Oleg V Korkushko, Valery B Shatilo, Vitaly M Kukharsky, Alexander M Vaiserman
Diabetes-related conditions such as chronic hyperglycemia and related oxidative stress and inflammation were repeatedly associated with accelerated telomere shortening in epidemiological studies, although some findings are inconsistent. In present study, we aimed to assess the impact of disturbances in glucose metabolism on association between age and leukocyte telomere length (LTL) in the Ukrainian population. The study was conducted on the 119 adult subjects aged between 43 and 87 years residing in the Kyiv region, Ukraine...
June 26, 2018: Experimental Gerontology
Alexandra Jungert, Monika Neuhäuser-Berthold
OBJECTIVE: Emerging evidence indicates that vitamin D has anti-oxidative properties. The present study investigates whether serum 25‑hydroxyvitamin D [25(OH)D] is associated with biomarkers of anti-oxidative status in community-dwelling older adults using cross-sectional and longitudinal data. METHODS: A total of 302 subjects aged 62 to 92 years from Germany (50.6°N) were analysed via cross-sectional approach. For longitudinal analysis, data of 153 subjects were available...
June 25, 2018: Experimental Gerontology
Yoko Shiotsu, Yuya Watanabe, Shotaro Tujii, Masahioko Yanagita
Arterial stiffness increases with advancing age, and is as an emerging biomarker in the assessment of vascular health. Some studies suggest that high-intensity resistance training increases arterial stiffness, but low- to moderate-intensity resistance training does not effect on arterial stiffening. Current evidence suggests that performing aerobic exercise after resistance training improved arterial stiffness in the young men and women. However, few studies have been conducted on the effects of the order of combined training on arterial stiffness in the elderly...
June 25, 2018: Experimental Gerontology
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