journal
MENU ▼
Read by QxMD icon Read
search

Experimental Gerontology

journal
https://www.readbyqxmd.com/read/28099881/mesencephalic-astrocyte-derived-neurotrophic-factor-alleviated-6-ohda-induced-cell-damage-via-ros-ampk-mtor-mediated-autophagic-inhibition
#1
Jingxing Zhang, Qiong Cai, Ming Jiang, Yigang Liu, Hua Gu, Jia Guo, Hui Sun, Jianmin Fang, Lingjing Jin
Autophagy and apoptosis are commonly involved in the dopaminergic neuron damage in the pathogenesis of Parkinson's disease. Recently, the autophagy pathway is thought to be critical to the process of PD. Therefore, the regulation of autophagy may be a potential strategy for PD treatment. Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been reported to have neuroprotective effects through anti-apoptosis, anti-oxidative, and anti-inflammatory mechanisms in PD. In this study, we investigated the role of autophagy system in MANF-mediated neuroprotection against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity...
January 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28095310/ilex-paraguariensis-supplementation-may-be-an-effective-nutritional-approach-to-modulate-oxidative-stress-during-perimenopause
#2
Ariana Aparecida Ferreira Pereira, Keny Gonçalves Tirapeli, Antonio Hernandes Chaves Neto, Matheus da Silva Brasilino, Cláudia Quintino da Rocha, Adriane Belló-Klein, Suzana Francisca Llesuy, Rita Cássia Menegati Dornelles, Ana Cláudia de Melo Stevanato Nakamune
Perimenopause is a period in a woman's life that precedes menopause and is characterized by hormonal changes that results in increased oxidative stress. Since oxidative stress is associated with age-related diseases and perimenopausal symptoms including somato-vegetative manifestations, nutritional antioxidant supplementation may be an effective approach to minimizing this stress. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense...
January 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28093317/stem-cell-therapies-in-preclinical-models-of-stroke-is-the-aged-brain-microenvironment-refractory-to-cell-therapy
#3
Raluca Elena Sandu, Adrian Balseanu, Catalin Bogdan, Mark Slevin, Eugen Petcu, Aurel Popa-Wagner
: Stroke is a devastating disease demanding vigorous search for new therapies. Initial enthusiasm to stimulate restorative processes in the ischemic brain by means of cell-based therapies has meanwhile converted into a more balanced view recognizingimpediments that may be related to unfavorable age-associated environments. Recent results using a variety of drug, cell therapy or combination thereof suggest that, (i) treatment with Granulocyte-Colony Stimulating Factor (G-CSF) in aged rats has primarily a beneficial effect on functional outcome most likely via supportive cellular processes such as neurogenesis; (ii) the combination therapy, G-CSF with mesenchymal cells (G-CSF+BM-MSC or G-CSF+BM-MNC) did not further improve behavioral indices, neurogenesis or infarct volume as compared to G-CSF alone in aged animals; (iii) better results with regard to integration of transplanted cells in the aged rat environment have been obtained using iPS of human origin; (iv) mesenchymal cells may be used as drug carriers for the aged post-stroke brains...
January 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28093316/molecular-mechanisms-of-uvb-induced-senescence-of-dermal-fibroblasts-and-its-relevance-for-photoaging-of-the-human-skin
#4
Maria Cavinato, Pidder Jansen-Dürr
Due to its ability to cross the epidermis and reach the upper dermis where it causes cumulative DNA damage and increased oxidative stress, UVB is considered the most harmful component of sunlight to the skin. The consequences of chronic exposition to UVB are related to photoaging and photocarcinogenesis. There are limitations to the study of human skin aging and for this reason the use of models is required. Human dermal fibroblasts submitted to mild and repeated doses of UVB are considered a versatile model to study UVB effects in the process of skin photoaging, which depends on the accumulation of senescent cells, in particular in the dermis...
January 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28077326/longevity-in-calumma-parsonii-the-world-s-largest-chameleon
#5
Giulia Tessa, Frank Glaw, Franco Andreone
Large body size of ectothermic species can be correlated with high life expectancy. We assessed the longevity of the world's largest chameleon, the Parson's chameleon Calumma parsonii from Madagascar by using skeletochronology of phalanges taken from preserved specimens held in European natural history museums. Due to the high bone resorption we can provide only the minimum age of each specimen. The highest minimum age detected was nine years for a male and eight years for a female, confirming that this species is exceptionally long living among chameleons...
January 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28069385/changes-of-renin-angiotensin-system-related-aminopeptidases-in-early-stage-alzheimer-s-disease
#6
Paul Richard Gard, Sara Fidalgo, Isabelle Lotter, Cassandra Richardson, Nicolas Farina, Jennifer Rusted, Naji Tabet
Activities of aminopeptidases A, B, and N (ApA, ApB & ApN) and insulin-regulated aminopeptidase (IRAP) have been seen to be decreased amongst patients with Alzheimer's disease (AD). All of these enzymes are involved with the brain renin-angiotensin system which is believed to be involved with learning and memory. This study aimed to explore the time course and the mechanisms underlying these changes. Serum samples were collected from 45 AD patients at the start of the study, and again 13months later (n=37)...
January 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28063943/genetic-variation-in-wrn-and-ischemic-stroke-general-population-studies-and-meta-analyses
#7
Mette Christoffersen, Ruth Frikke-Schmidt, Børge G Nordestgaard, Anne Tybjærg-Hansen
BACKGROUND: Werner syndrome, a premature genetic aging syndrome, shares many clinical features reminiscent of normal physiological aging, and ischemic vascular disease is a frequent cause of death. We tested the hypothesis that genetic variation in the WRN gene was associated with risk of ischemic vascular disease in the general population. METHODS: We included 58,284 participants from two general population cohorts, the Copenhagen City Heart Study(CCHS) and the Copenhagen General Population Study(CGPS)...
January 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28062372/uric-acid-may-be-protective-against-cognitive-impairment-in-older-adults-but-only-in-those-without-cardiovascular-risk-factors
#8
Busra Tuven, Pinar Soysal, Gulcin Unutmaz, Derya Kaya, Ahmet Turan Isik
Uric acid (UA) may not only prevent development of cognitive dysfunction owing to its antioxidant efficacy, but also may worsen cognitive functions by gaining pro-oxidant character. The present study attempts to uncover this paradoxical association between UA and cognitive impairment in elderly. 1374 elderly patients were retrospectively evaluated and included in the study. Participants underwent determination of circulating UA levels and comprehensive geriatric assessment. A serum UA concentration≥7.0mg/dL in males and ≥5...
January 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28062370/treadmill-exercise-alleviates-motor-deficits-and-improves-mitochondrial-import-machinery-in-an-mptp-induced-mouse-model-of-parkinson-s-disease
#9
Jung-Hoon Koo, Joon-Yong Cho, Ung-Bae Lee
Alpha-synuclein (α-Syn) accumulation is significantly correlated with motor deficits and mitochondrial dysfunction in Parkinson's disease (PD), but the molecular mechanism underlying its pathogenesis is unclear. In this study, we investigated the effects of treadmill exercise on motor deficits and mitochondrial dysfunction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. Treadmill exercise inhibited dopaminergic neuron loss by promoting the expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) and seemed to improve cell survival by reducing α-Syn expression...
January 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28062371/effects-of-body-mass-index-and-weight-change-on-mortality-in-older-men-with-impaired-glucose-regulation
#10
Zhi-Bing Li, Man-Liu Wang, Sheng-Yong Dong, Ban-Ruo Sun, Xin-Yu Miao, Fu-Sheng Fang, Zheng-Xue Dai, Chun-Lin Li, Hui Tian
OBJECTIVES: To assess the effect of baseline body mass index (BMI) status and weight change on mortality in older men with impaired glucose regulation (IGR). METHODS: Eight hundred eighty-five men with IGR aged 60 to 90 were included. Baseline and endpoint weight were measured. All-cause and cardiovascular mortality were observed during a median follow-up period of 10years. Multivariate Cox regressions were used to estimate associations between BMI, weight change and mortality...
January 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28057563/uric-acid-and-endothelial-function-in-elderly-community-dwelling-subjects
#11
Andrea Ticinesi, Fulvio Lauretani, Gian Paolo Ceda, Carmelinda Ruggiero, Luigi Ferrucci, Rosalia Aloe, Anders Larsson, Tommy Cederholm, Lars Lind, Tiziana Meschi, Marcello Maggio
The role of serum uric acid (SUA), an inflammatory agent and potential mediator of cardiovascular diseases, in Endothelial Function (EF) has been tested only in middle-aged subjects affected by specific diseases. Our aim was to assess the relationship between SUA and measures of EF in a cohort of elderly community-dwellers. This study involved 424 males and 426 females aged 70years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), having complete data on SUA and EF assessed by flow-mediated vasodilation (FMD) and by intra-arterial infusion of acetylcholine (endothelium-dependent vasodilation, EDV) and sodium nitroprusside (endothelium-independent vasodilation, EIDV)...
January 2, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28043934/sex-differences-in-frailty-a-systematic-review-and-meta-analysis
#12
REVIEW
E H Gordon, N M Peel, M Samanta, O Theou, S E Howlett, R E Hubbard
BACKGROUND: It is a well-described clinical phenomenon that females live longer than males, yet tend to experience greater levels of co-morbidity and disability. Females can therefore be considered both more frail (because they have poorer health status) and less frail (because they have a lower risk of mortality). This systematic review aimed to determine whether this ageing paradox is demonstrated when the Frailty Index (FI) is used to measure frailty. METHODS: Medline, EMBASE and CINAHL databases were searched for observational studies that measured FI and mortality in community-dwellers over 65years of age...
December 30, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28039025/common-variants-of-human-tert-and-terc-genes-and-susceptibility-to-sporadic-alzheimers-disease
#13
D Scarabino, E Broggio, G Gambina, F Pelliccia, R M Corbo
Studies investigating telomere length in association with cognitive decline, dementia, and sporadic Alzheimer's disease (AD) have frequently found shorter telomeres to be associated with the development of AD and telomerase expression with pathological processes in AD. Human telomerase is constituted by two components: the telomerase reverse transcriptase (TERT) and the telomerase RNA component (TERC). Genetic variation at the two loci has been investigated in relation to telomere length, longevity, and common diseases of advanced age, but not in relation to AD...
December 27, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28039024/effects-of-age-and-caloric-restriction-in-the-vascular-response-of-renal-arteries-to-endothelin-1-in-rats
#14
Sara Amor, Angel Luis García-Villalón, Carmen Rubio, Jose Ma Carrascosa, Luis Monge, Nuria Fernández, Beatriz Martín-Carro, Miriam Granado
Cardiovascular alterations are the most prevalent cause of impaired physiological function in aged individuals with kidney being one the most affected organs. Aging-induced alterations in renal circulation are associated with a decrease in endothelium-derived relaxing factors such as nitric oxide (NO) and with an increase in contracting factors such as endothelin-1(ET-1). As caloric restriction (CR) exerts beneficial effects preventing some of the aging-induced alterations in cardiovascular system, the aim of this study was to analyze the effects of age and caloric restriction in the vascular response of renal arteries to ET-1 in aged rats...
December 27, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28034763/using-neonatal-skin-to-study-the-developmental-programming-of-aging
#15
Leryn J Reynolds, Brett J Dickens, Benjamin B Green, Carmen J Marsit, Kevin J Pearson
Numerous studies have examined how both negative and positive maternal exposures (environmental contaminants, nutrition, exercise, etc.) impact offspring risk for age-associated diseases such as obesity, type 2 diabetes, hypertension, and others. The purpose of this study was to introduce the foreskin as a novel model to examine developmental programming in human neonates, particularly in regards to adipogenesis and insulin receptor signaling, major contributors to age-associated diseases such as obesity and diabetes...
December 27, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28025126/digital-technology-to-enable-aging-in-place
#16
REVIEW
Kwang-Il Kim, Shreya S Gollamudi, Steven Steinhubl
Aging, both of individuals and populations, presents challenges and opportunities. The multitude of morbidities and disabilities that are a too common component of aging represent significant challenges to individuals, their families and to healthcare systems. Aging in place is the ability to safely and comfortably maintain an independent and high quality of life in one's own home and community and is a highly desirable goal of most individuals with the additional benefit of significantly impacting the impending enormous healthcare burden...
December 24, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28025127/glucose-tolerance-and-insulin-sensitivity-are-impaired-in-app-ps1-transgenic-mice-prior-to-amyloid-plaque-pathogenesis-and-cognitive-decline
#17
Lauren Macklin, Chelsea M Griffith, Yan Cai, Gregory M Rose, Xiao-Xin Yan, Peter R Patrylo
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Clinical data suggests that both type 1 and type 2 diabetes are risk factors for AD-related dementia and several clinical studies have demonstrated that AD patients show alterations in peripheral glucose regulation characterized by insulin resistance (hyperinsulinemia) or hypoinsulinemia. Whether animal models of AD exhibit a pre-diabetic phenotype without additional dietary or experimental manipulation is unclear however, with contradictory data available...
December 23, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28017716/effects-of-learning-on-mtor-pathway-gene-expression-in-the-brain-of-zebrafish-danio-rerio-of-different-ages
#18
Carolina da Silva Peixoto, Gustavo Morrone Parfitt, Gisele Eva Bruch, Marcos Freitas Cordeiro, Daniela Volcan Almeida, Luis Fernando Fernandes Marins, Daniela Martí Barros
Target of rapamycin (TOR) is a protein kinase involved in the modulation of mRNA translation and, therefore, in the regulation of protein synthesis. In neurons, the role of TOR is particularly important in the consolidation of long-term memory (LTM). One of the modulators of TOR is brain-derived neurotrophic factor (BDNF), which activates the TOR signaling pathway to promote protein synthesis, synapse strengthening, and the creation of new neural networks. We investigated the gene expression pattern of this pathway during memory consolidation in zebrafish of different ages...
December 23, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28012941/age-related-arterial-immune-cell-infiltration-in-mice-is-attenuated-by-caloric-restriction-or-voluntary-exercise
#19
Daniel W Trott, Grant D Henson, Mi H T Ho, Sheilah A Allison, Lisa A Lesniewski, Anthony J Donato
Age-related arterial inflammation is associated with dysfunction of the arteries and increased risk for cardiovascular disease. To determine if aging increases arterial immune cell infiltration as well as the populations of immune cells principally involved, we tested the hypothesis that large elastic and resistance arteries in old mice would exhibit increased immune cell infiltration compared to young controls. Additionally, we hypothesized that vasoprotective lifestyle interventions such as lifelong caloric restriction or 8weeks of voluntary wheel running would attenuate age-related arterial immune cell infiltration...
December 22, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28011241/role-of-fruits-nuts-and-vegetables-in-maintaining-cognitive-health
#20
Marshall G Miller, Nopporn Thangthaeng, Shibu M Poulose, Barbara Shukitt-Hale
Population aging is leading to an increase in the incidence of age-related cognitive dysfunction and, with it, the health care burden of caring for older adults. Epidemiological studies have shown that consumption of fruits, nuts, and vegetables is positively associated with cognitive ability; however, these foods, which contain a variety of neuroprotective phytochemicals, are widely under-consumed. Surprisingly few studies have investigated the effects of individual plant foods on cognitive health but recent clinical trials have shown that dietary supplementation with individual foods, or switching to a diet rich in several of these foods, can improve cognitive ability...
December 20, 2016: Experimental Gerontology
journal
journal
21351
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"