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Experimental Gerontology

I Rostás, J Tenk, A Mikó, N Füredi, S Soós, M Solymár, A Lengyel, M Székely, B Gaszner, D Feller, E Pétervári, M Balaskó
Leptin is a key catabolic regulator of food intake (FI) and energy expenditure. Both aging and obesity have been shown to induce leptin-resistance. The present study aimed to analyze age-related changes in the anorexigenic and hypermetabolic responsiveness to acute intracerebroventricular leptin administration in different age-groups of normally fed male Wistar rats (adult and old rats from 3 to 24months of age, NF3 to NF24, respectively). The expressions of the long form of the leptin receptor (Ob-Rb) and inhibitory SOCS3 genes were also assessed by quantitative RT-PCR in the arcuate nucleus (ARC)...
October 22, 2016: Experimental Gerontology
Stanislava Stanojević, Ivana Ćuruvija, Veljko Blagojević, Raisa Petrović, Vesna Vujić, Mirjana Dimitrijević
Rats of Albino Oxford (AO) strain in our animal facility exhibit a longer average healthy life span than rats of Dark Agouit (DA) strain. Since chronic activation of macrophages contributes to chronic low level inflammation common in older age, elucidation of the changes in middle-aged rats could be useful in prevention of unbalanced inflammatory response in advanced age. We have analysed the phenotype of unelicited and thioglycollate-elicited peritoneal macrophages from young and middle-aged DA and AO rats and tested functions of these cells following stimulation with lipopolysaccharide (LPS) in vitro...
October 15, 2016: Experimental Gerontology
Ma Paz Redondo-Del-Río, Ma Alicia Camina-Martín, Laura Moya-Gago, Sandra de-la-Cruz-Marcos, Vincenzo Malafarina, Beatriz de-Mateo-Silleras
OBJECTIVE: To compare body composition as assessed by conventional and vector bioelectrical impedance analysis according to the nutritional cataloging using body mass index (BMI) in a group of institutionalized elderly. METHODS: Cross-sectional study in 38 institutionalized elderly. Body composition was estimated by bioimpedance analysis. Differences in body composition were analyzed using t-test and ANOVA, or their corresponding nonparametric tests. Statistical significance was set at p<0...
October 10, 2016: Experimental Gerontology
Paweł Nadrowski, Jerzy Chudek, Michał Skrzypek, Monika Puzianowska-Kuźnicka, Małgorzata Mossakowska, Andrzej Więcek, Tomasz Zdrojewski, Tomasz Grodzicki, Krystyna Kozakiewicz
BACKGROUND: Age-related diseases, including cardiovascular diseases (CVD) may be stimulated by microinflammation, marked by increased level of IL-6 and high-sensitivity CRP (hsCRP). We aimed to investigate whether aging "per se" independently contributesto themicroinflammation,inadditionto traditional and novel CVD risk factors. METHODS/RESULTS: The research sample included 4979 participants from PolSenior Study, aged over 65years. The study consisted of threevisitsandincludedquestionnairesurvey,geriatricassessmentandblood/urinesamplingin4101 participants (83...
October 8, 2016: Experimental Gerontology
Gustavo Costa, Manel Garabito, Francesc Jiménez-Altayó, Yara Onetti, Manel Sabate, Elisabet Vila, Ana Paula Dantas
Aging is a cardiovascular risk factor partially related to activation of the Renin-Angiotensin System (RAS). RAS activation is also influenced by sex. In this regard, our study aims to determine whether sex-associated differences in RAS contribute to a differential regulation of vascular aging and associated dysfunction. Male and female outbreed CD-1 mice were studied at 3 and 12months of age (M). Contribution of RAS was determined by treating mice from 3M to 12M with the AngII type 1 receptor blocker losartan (0...
October 3, 2016: Experimental Gerontology
Yujiro Kose, Masahiro Ikenaga, Yosuke Yamada, Kazuhiro Morimura, Noriko Takeda, Shinji Ouma, Yoshio Tsuboi, Tatsuo Yamada, Misaka Kimura, Akira Kiyonaga, Yasuki Higaki, Hiroaki Tanaka
AIM: This study aimed to ascertain if performance on the Timed Up and Go (TUG) test is associated with indicators of brain volume and cognitive functions among community-dwelling older adults with normal cognition or mild cognitive impairment. METHODS: Participants were 80 community-dwelling older adults aged 65-89years (44 men, 36 women), including 20 with mild cognitive impairment. Participants completed the TUG and a battery of cognitive assessments, including the Mini-Mental State Examination (MMSE), the Logical Memory I and II (LM-I, LM-II) subtests of the Wechsler Memory Scale-Revised; and the Trail Making Test A and B (TMT-A, TMT-B)...
September 28, 2016: Experimental Gerontology
Aakanksha Pant, Shilpi K Saikia, Virendra Shukla, Jyotsna Asthana, Bashir A Akhoon, Rakesh Pandey
No abstract text is available yet for this article.
September 28, 2016: Experimental Gerontology
Jeong-Ho Park, Martina Mancini, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak
Although balance and gait deteriorate as a person ages, it is unknown if all balance and gait measures change similarly across the adult age span. We developed the Instrumented Stand and Walk test (ISAW) to provide a quick quantification of key components of balance and walking: postural sway, anticipatory postural adjustments during step initiation, gait, and turning using body-worn, inertial sensors. Our aims were to characterize how different balance and gait measures change with age and to identify key age-related measures of mobility, in a wide age range of healthy, community-dwelling adults...
September 22, 2016: Experimental Gerontology
Miguel Diaz, Hans Degens, Luc Vanhees, Clare Austin, May Azzawi
Aging is a major risk factor for the development of cardiovascular disease. Despite a significant reduction in the mortality and morbidity rates over the last decade, the socio-economic burden of cardiovascular disease is still substantial. Consequently, there is a considerable need for alternative strategies, such as nutraceutical supplementation, that delay the functional vascular decline present in the elderly. Compromised autophagy and oxidative stress (OS) are considered major causes of the age-related endothelial dysfunction...
September 22, 2016: Experimental Gerontology
Pedro A Pereira, Tiago Millner, Manuel Vilela, Sérgio Sousa, Armando Cardoso, M Dulce Madeira
The medial prefrontal cortex (mPFC) has been identified as a critical center for working and long-term memory. In this study, we have examined the expression of neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP) in mPFC interneurons and the density of the mPFC cholinergic and dopaminergic innervation in cognitively-impaired aged Wistar rats. We also tested the possibility that the potential age-related changes might rely on insufficient neurotrophic support. The total number of NPY- and VIP-immunoreactive neurons and the density of vesicular acetylcholine transporter (VAChT)- and tyrosine hydroxylase (TH)-immunoreactive varicosities were estimated using stereological methods...
September 21, 2016: Experimental Gerontology
Tapan Mehta, Nicholas M Pajewski, Scott W Keith, Kevin Fontaine, David B Allison
CONTEXT: Recent analyses of epidemiological data including the National Health and Nutrition Examination Survey (NHANES) have suggested that the harmful effects of obesity may have decreased over calendar time. The shifting BMI distribution over time coupled with the application of fixed broad BMI categories in these analyses could be a plausible "nuisance contributor" to this observed change in the obesity-associated mortality over calendar time. OBJECTIVE: To evaluate the extent to which observed temporal changes in the obesity-mortality association may be due to a shifting population distribution for body mass index (BMI), coupled with analyses based on static, broad BMI categories...
September 17, 2016: Experimental Gerontology
Tolunay Beker Aydemir, Catalina Troche, Jinhee Kim, Min-Hyun Kim, Oriana Y Teran, Christiaan Leeuwenburgh, Robert J Cousins
Inflammation and zinc dyshomeostasis are two common hallmarks of aging. A major zinc transporter ZIP14 (slc39a14) is upregulated by proinflammatory stimuli, e.g. interleukin-6. We have evaluated the influence of age on the Zip14 KO phenotype using wild-type (WT) and Zip14 knockout (KO) mice. Aging produced a major increase in serum IL-6 concentrations that was dramatically augmented in the Zip14 KO mice. In keeping with enhanced serum IL-6 concentrations, aging produced tissue-specific increases in zinc concentration of skeletal muscle and white adipose tissue...
September 16, 2016: Experimental Gerontology
Alexandra Vaccaro, Serge Birman, André Klarsfeld
Endogenous circadian clocks with ~24-h periodicity are found in most organisms from cyanobacteria to humans. Daylight synchronizes these clocks to solar time. In humans, shift-work and jet lag perturb clock synchronization, and such perturbations, when repeated or chronic, are strongly suspected to be detrimental to healthspan. Here we investigated locomotor aging and longevity in Drosophila melanogaster with genetically or environmentally disrupted clocks. We compared two mutations in period (per, a gene essential for circadian rhythmicity in Drosophila), after introducing them in a common reference genetic background: the arrhythmic per(01), and per(T) which displays robust short 16-h rhythms...
September 14, 2016: Experimental Gerontology
Anna Picca, Vito Pesce, Giuseppe Sirago, Flavio Fracasso, Christiaan Leeuwenburgh, Angela Maria Serena Lezza
Extremely interesting for aging research are those individuals able to reach older ages still with functions similar to those of younger counterparts. We examined liver samples from ad libitum-fed old (28-month-old, AL-28) and ad libitum-fed very old (32-month-old, AL-32) rats for a number of markers, relevant for mitochondrial functionality and mitochondrial DNA (mtDNA) content. As for the mtDNA content and the protein amounts of the citrate synthase and the antioxidant peroxiredoxin III there were no significant changes in the AL-32 animals...
September 13, 2016: Experimental Gerontology
Francesco Curcio, Gaetana Ferro, Claudia Basile, Ilaria Liguori, Paolo Parrella, Flora Pirozzi, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Carlo Gabriele Tocchetti, Domenico Bonaduce, Pasquale Abete
The slow and continuous loss of muscle mass that progresses with aging is defined as "sarcopenia". Sarcopenia represents an important public health problem, being closely linked to a condition of frailty and, therefore, of disability. According to the European Working Group on Sarcopenia in Older People, the diagnosis of sarcopenia requires the presence of low muscle mass, along with either low grip strength or low physical performance. However, age-related changes in skeletal muscle can be largely attributed to the complex interactions among factors including alterations of the neuromuscular junction, endocrine system, growth factors, and muscle proteins turnover, behavior-related and disease-related factors...
September 12, 2016: Experimental Gerontology
Jacob E Schmidt, Aubrey E Sirman, Jeffrey D Kittilson, Mark E Clark, Wendy L Reed, Britt J Heidinger
Telomere dynamics in blood cells have been linked to aging in a variety of organisms. However, whether blood telomeres are correlated with telomeres in other parts of the body is not well known, especially during early life when telomere loss is expected to be most rapid. We investigated this question in Franklin's gulls (Leucophaeus pipixcan) by measuring telomere lengths in blood and several other tissues including: heart, liver, and skeletal muscle at the end of embryonic (n=31) and post-natal development (n=20)...
September 12, 2016: Experimental Gerontology
Boris H Kramer, Ralf Schaible, Alexander Scheuerlein
Eusociality has been recognized as a strong driver of lifespan evolution. While queens show extraordinary lifespans of 20years and more, worker lifespan is short and variable. A recent comparative study found that in eusocial species with larger average colony sizes the disparities in the lifespans of the queen and the worker are also greater, which suggests that lifespan might be an evolved trait. Here, we tested whether the same pattern holds during colony establishment: as colonies grow larger, worker lifespan should decrease...
September 10, 2016: Experimental Gerontology
Luciana Marina Sánchez, Romina Cármen De Lucca, Marianela Lewicki, Ángela Matilde Ubios
: Increasing duration of type 1 diabetes mellitus alters bone metabolism. Clinical studies and experimental studies in long bones of rats with experimentally induced diabetes have reported a decrease in bone density. Few studies have explored this diabetes related alteration in the maxillae. Given that this finding could indicate the possible development of osteopenia in the maxilla in the long term, the present study sought to analyze alterations in alveolar bone in aged rats, 12, 18, and 24weeks after inducing diabetes, and compare alveolar bone response to that of tibial subchondral bone at the same experimental times...
September 9, 2016: Experimental Gerontology
Angelica C Alonso, Mark D Peterson, Alexandre L Busse, Wilson Jacob-Filho, Mauricio T A Borges, Marcos M Serra, Natalia M S Luna, Paulo H Marchetti, Júlia M D A Greve
BACKGROUND: Despite the well-known declines in driving performance with advancing age, there is little understanding of the specific factors that predict changes in key determinants such as braking time. OBJECTIVES: The aims of this study were to determine the extent to which age, muscle strength, cognition and postural balance are associated with braking performance in middle-aged and older adults. METHODS: Male and female middle-aged adults (n=62, age=39...
September 8, 2016: Experimental Gerontology
Anoop Balachandran, Maria M Martins, Federico G De Faveri, Ozgur Alan, Funda Cetinkaya, Joseph F Signorile
No abstract text is available yet for this article.
August 25, 2016: Experimental Gerontology
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