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Experimental Gerontology

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https://www.readbyqxmd.com/read/28652180/serum-levels-of-dickkopf-1-are-a-potential-negative-biomarker-of-survival-in-geriatric-patients
#1
Peter Dovjak, Georg Heinze, Anna Rainer, Wolfgang Sipos, Peter Pietschmann
Fragility fractures due to osteoporosis and its most dreaded complication - hip fractures - are the cause of disability, high mortality and place a considerable burden on global health economics. Although much work has been done to accurately predict mortality and find risk factors for poor health outcome, little attention was given to the Wnt-catenin signaling pathway and its role in the posttraumatic course of disease. We studied 238 geriatric patients (175 women (mean age 84yrs) and 63 men (mean age 82yrs)) in total that were admitted to a department of Acute Geriatric Care...
June 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28652179/non-coding-rna-regulation-of-t-cell-biology-implications-for-age-associated-cardiovascular-diseases
#2
REVIEW
Jose Coelho-Lima, Ioakim Spyridopoulos
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored...
June 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28647519/is-sarcopenia-associated-with-an-increased-risk-of-all-cause-mortality-and-functional-disability
#3
George A Kelley, Kristi S Kelley
BACKGROUND: While a recent meta-analysis of observational studies reported a statistically significant association between sarcopenia and both all-cause mortality and functional decline, a recently developed inverse heterogeneity (IVhet) model has been shown to be more valid than the traditional random-effects model used. OBJECTIVE: The objective of this short report was to use a previous meta-analysis to compare the two approaches. METHODS: Aggregate data meta-analysis of prospective observational studies conducted in any setting...
June 21, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28645696/exercise-training-improves-functional-status-in-hypertensive-older-adults-under-angiotensin-converting-enzymes-inhibitors-medication
#4
Liliana C Baptista, Aristides M Machado-Rodrigues, Manuel Teixeira Veríssimo, Raul A Martins
BACKGROUND: The study aims to analyze the effect of three types of treatment on functional status, and cardiovascular risk outcomes in hypertensive older adults with comorbidities. METHODS: Participants (n=418) underwent one of the following 3 conditions: i) multicomponent exercise training 3times/week (MEX; n=116); ii) angiotensin converting enzyme inhibitors used mono-dose daily (ACEi; n=70); iii) combined exercise and ACEi drugs (ACEiMEX; n=232). The trial was completed by 82% of the participants (n=342): MEX (n=90); ACEi (n=66); ACEiMEX (n=186)...
June 20, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28642074/comment-on-serum-uric-acid-is-associated-with-better-executive-function-in-men-but-not-in-women-baseline-assessment-of-the-elsa-brasil-study
#5
LETTER
Pinar Soysal
No abstract text is available yet for this article.
June 19, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28634089/wedelolactone-a-plant-coumarin-prevents-vascular-smooth-muscle-cell-proliferation-and-injury-induced-neointimal-hyperplasia-through-akt-and-ampk-signaling
#6
Lu Peng, Xuefeng Huang, Xin Jin, Zuo Jing, Lichao Yang, Yu Zhou, Jie Ren, Yun Zhao
Wedelolactone (WDL) is a natural compound derived from Chinese herbal medicine Eclipta prostrate L, and has been reported to exhibit various effects potentially beneficial for human health. However, the possible preventive effects of WDL toward vascular remodeling and mechanisms involved have not been investigated to date. In this study, we investigated the effects of WDL on proliferation induced by platelet-derived growth factor (PDGF) in primary rat aortic smooth muscle cells (VSMCs) and on neointimal hyperplasia resulted from balloon injury in rats...
June 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28633865/corrigendum-to-neural-correlates-of-reduced-awareness-in-instrumental-activities-of-daily-living-in-frontotemporal-dementia-exp-gerontol-83-2016-158-164
#7
Martina Amanzio, Federico D'Agata, Sara Palermo, Elisa Rubino, Milena Zucca, Antonello Galati, Lorenzo Pinessi, Giancarlo Castellano, Innocenzo Rainero
No abstract text is available yet for this article.
June 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28625601/role-of-social-interaction-exercise-diet-and-age-on-developing-and-untreated-diabetes-in-cynomolgus-monkeys
#8
Feng Yue, Guodong Zhang, Jorge E Quintero, Don M Gash, Zhiming Zhang
Type 2 diabetes mellitus is the most common form of diabetes that occurs in both human and nonhuman primates. Although spontaneously diabetic nonhuman primates are used extensively in diabetic related research and are a proven valuable tool for the study of the natural history of diabetes, little is known about the key factors that can cause this metabolic disorder and the preventative measures that could be employed to minimize the consequences of diabetes. Using a model of developing and untreated diabetes, this study describes the effects of housing arrangement (socially group- versus individually single-housed), exercise, diet, age, and sex on fasting plasma glucose, key lipids associated with diabetes, and bodyweight in two large cohorts of nonhuman primates...
June 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28624356/vascular-ageing-underlying-mechanisms-and-clinical-implications
#9
REVIEW
Ageliki Laina, Konstantinos Stellos, Kimon Stamatelopoulos
Epidemiological studies have shown that ageing is a major non-reversible risk factor for cardiovascular disease. Vascular ageing starts early in life and is characterized by a gradual change of vascular structure and function resulting in increased arterial stiffening. At the present review we discuss the role of the most important molecular pathways involved in vascular ageing, their association with arterial stiffening and possible novel therapeutic targets that may delay this otherwise irreversible degenerating process...
June 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28624355/3-np-induced-huntington-s-like-disease-impairs-nrf2-activation-without-loss-of-cardiac-function-in-aged-rats
#10
A Silva-Palacios, M Ostolga-Chavarría, M Buelna-Chontal, C Garibay, S Hernández-Reséndiz, F J Roldán, P L Flores, A Luna-López, M Königsberg, C Zazueta
Cardiovascular diseases (CVDs) are one of the leading causes of death in patients over 60years with Huntington's disease (HD). Here, we investigated if age-related oxidative stress (OS) is a relevant factor to develop cardiac damage in an in vivo model of striatal neurodegeneration induced by 3-nitropropionic acid (3-NP). We also evaluated the potential effect of tert-butylhydroquinone (tBHQ) to increase the Nrf2-regulated antioxidant response in hearts from adult and aged rats intoxicated with 3-NP. Our results showed that 3-NP-treatment did not induce cardiac dysfunction, neither in adult nor in aged rats...
June 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28615120/corrigendum-to-asynchrony-of-senescence-among-phenotypic-traits-in-a-wild-mammal-population-exp-gerontol-71-2015-56-68
#11
Adam D Hayward, Jacob Moorad, Charlotte E Regan, Camillo Berenos, Jill G Pilkington, Josephine M Pemberton, Daniel H Nussey
No abstract text is available yet for this article.
June 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28606482/the-neuron-astrocyte-microglia-triad-in-ca3-after-chronic-cerebral-hypoperfusion-in-the-rat-protective-effect-of-dipyridamole
#12
Daniele Lana, Filippo Ugolini, Alessia Melani, Daniele Nosi, Felicita Pedata, Maria Grazia Giovannini
We investigated the quantitative and morphofunctional alterations of neuron-astrocyte-microglia triads in CA3 hippocampus, in comparison to CA1, after 2 Vessel Occlusion (2VO) and the protective effect of dipyridamole. We evaluated 3 experimental groups: sham-operated rats (sham, n=15), 2VO-operated rats treated with vehicle (2VO-vehicle, n=15), and 2VO-operated rats treated with dipyridamole from day 0 to day 7 (2VO-dipyridamole, n=15), 90days after 2VO. We analyzed Stratum Pyramidalis (SP), Stratum Lucidum (SL) and Stratum Radiatum (SR) of CA3...
June 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28602957/mitochondrial-dynamics-signaling-is-shifted-toward-fusion-in-muscles-of-very-old-hip-fractured-patients-results-from-the-sarcopenia-in-hip-fracture-shift-exploratory-study
#13
Anna Picca, Riccardo Calvani, Maria Lorenzi, Amerigo Menghi, Marco Galli, Raffaele Vitiello, Francesco Randisi, Roberto Bernabei, Francesco Landi, Emanuele Marzetti
BACKGROUND: Mitochondrial quality control (MQC) is crucial for maintaining mitochondrial fitness. We investigated MQC signaling in muscle of old hip-fractured patients. METHODS: Twenty-three patients, enrolled in the Sarcopenia in HIp FracTure (SHIFT) study, were categorized into old (OL; n=8) and very old groups (VOL; n=15) using 85years as the cut-off. The expression of a set of MQC signaling proteins was assayed in vastus lateralis muscle biopsies. RESULTS: The content of lysosome-associated membrane protein 2, microtubule-associated protein 1 light chain 3B, optic atrophy protein 1, fission protein 1 (Fis1), peroxisome proliferator-activated receptor-γ coactivator-1α, and forkhead box O3 was unvaried between groups...
June 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28599951/age-gender-and-percentage-of-circulating-osteoprogenitor-cop-cells-the-cop-study
#14
Piumali Gunawardene, Ahmed Al Saedi, Lakshman Singh, Sandra Bermeo, Sara Vogrin, Steven Phu, Pushpa Suriyaarachchi, Robert J Pignolo, Gustavo Duque
Circulating osteoprogenitor (COP) cells are blood-borne cells which express a variety of osteoblastic markers and are able to form bone nodules in vivo. Whereas a high percentage of COP cells (%COP) is associated with vascular calcification, low %COP has been associated with disability and frailty. However, the reference range of %COP in age- and gender-matching populations, and the age-related changes in %COP remain unknown. A cross-sectional study was undertaken in 144 healthy volunteers in Western Sydney (20-90year-old, 10 male and 10 female subjects per decade)...
June 6, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28587932/preliminary-evidence-that-age-and-sex-affect-exercise-induced-htert-expression
#15
Travis G Cluckey, Nathan C Nieto, Bridger M Rodoni, Tinna Traustadóttir
The ability to repair cellular damage is reduced with aging, resulting in cellular senescence. Telomeres shorten as cells divide but the rate of telomere attrition is modulated by telomerase, an enzyme that adds nucleotides to the chromosome. Shelterin is a protein complex that acts as a negative regulator of telomerase. The aim of the present study was to investigate age-related differences in telomerase and shelterin responses to acute exercise. We hypothesized that acute exercise would stimulate an increased activity of telomerase (measured by telomerase reverse transcriptase, hTERT) without an increase in activity of shelterin (measured by telomeric repeat binding factor 2, TRF2) in both young and older individuals and that hTERT response would be attenuated in older individuals...
June 3, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28579089/muscle-strength-and-force-development-in-high-and-low-functioning-elderly-men-influence-of-muscular-and-neural-factors
#16
Charlotte H Pion, Sébastien Barbat-Artigas, Félix St-Jean-Pelletier, Stéphanie Chevalier, Pierrette Gaudreau, Gilles Gouspillou, José A Morais, Marc Bélanger, Mylène Aubertin-Leheudre
BACKGROUND: Aging leads to a loss of muscle strength and functional capacity likely resulting from a combination of neural and muscle alterations. The aim of this study was to identify possible disparities in muscle strength and force development profiles in high- and low-functioning elderly men and to investigate muscular and neurophysiological factors that could explain the differences. METHODS: Sixty community-dwelling men in good general health were divided in two groups based on a functional capacity (FC) z-score derived from 6 tests of the Short Physical Performance Battery and Senior Fitness Test (Normal and fast 4m-walk tests, normal and fast Timed-up and go, chair and stair tests)...
June 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28577890/exercise-training-protects-against-aging-induced-mitochondrial-fragmentation-in-mouse-skeletal-muscle-in-a-pgc-1%C3%AE-dependent-manner
#17
Jens Frey Halling, Stine Ringholm, Jesper Olesen, Clara Prats, Henriette Pilegaard
Aging is associated with impaired mitochondrial function, whereas exercise training enhances mitochondrial content and function in part through activation of PGC-1α. Mitochondria form dynamic networks regulated by fission and fusion with profound effects on mitochondrial functions, yet the effects of aging and exercise training on mitochondrial network structure remain unclear. This study examined the effects of aging and exercise training on mitochondrial network structure using confocal microscopy on mitochondria-specific stains in single muscle fibers from PGC-1α KO and WT mice...
May 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28554736/heat-transfer-and-loss-by-whole-body-hyperthermia-during-severe-lower-body-heating-are-impaired-in-healthy-older-men
#18
Marius Brazaitis, Henrikas Paulauskas, Nerijus Eimantas, Diana Obelieniene, Neringa Baranauskiene, Albertas Skurvydas
Most studies demonstrate that aging is associated with a weakened thermoregulation. However, it remains unclear whether heat transfer (for heat loss) from the lower (uncompensable) to the upper (compensable) body during passively-induced severe lower-body heating is delayed or attenuated with aging. Therefore, the main purpose of this study was to investigate heat transfer from uncompensable to compensable body areas in young men and healthy older men during passively-induced whole-body hyperthermia with a demonstrated post-heating change in core body (rectal; Tre) temperature...
May 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28546086/physical-activity-and-cardiovascular-aging-physiological-and-molecular-insights
#19
REVIEW
Djordje G Jakovljevic
Aging is associated with significant changes in both cardiac and vascular structure and function that lower the threshold for clinical signs and symptoms, making older people more susceptible to cardiovascular diseases, morbidity and mortality. Understanding of age-related cardiovascular changes is necessary for effective and efficient prevention and treatment of cardiovascular disease in older people. Cardiac aging is associated with left ventricular remodelling marked by increased mass-to-volume ratio and accompanied by systolic and diastolic myocardial dysfunction, and reduced sensitivity to sympathetic stimuli that compromises myocardial contractility and pumping ability in older people...
May 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28535950/aging-related-changes-in-human-t-cell-repertoire-over-20years-delineated-by-deep-sequencing-of-peripheral-t-cell-receptors
#20
Kengo Yoshida, John B Cologne, Kismet Cordova, Munechika Misumi, Mika Yamaoka, Seishi Kyoizumi, Tomonori Hayashi, Harlan Robins, Yoichiro Kusunoki
Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide antigens, including viral and tumor antigens. The human TCR repertoire declines with age, but this decline has not been fully investigated longitudinally in individuals. Using a deep sequencing approach, we analyzed TCRβ repertoires longitudinally over approximately 20years, with ages ranging from 23 to 50years at the start (23 to 65years overall), in peripheral-blood CD4 and CD8 T-cell populations that were collected and cryopreserved 3 times at intervals of approximately 10years from each of 6 healthy adults (3 men and 3 women)...
May 20, 2017: Experimental Gerontology
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