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Experimental Gerontology

J Grant Mouser, Matthew B Jessee, Kevin T Mattocks, Zachary W Bell, Samuel L Buckner, Scott J Dankel, Takashi Abe, Jeremy P Loenneke
No abstract text is available yet for this article.
January 17, 2018: Experimental Gerontology
Kayvan Zainabadi
Over the last few decades, ageing research has emerged as a vibrant area of rigorous scientific study. With its humble beginnings in yeast and worms, the field has progressed so dramatically that scientists are now able to extend the lifespan of mice with use of small molecule drugs. However, it was not too long ago that answering the more basic question, whether ageing itself was amenable to scientific study, was itself a topic of contentious debate. To begin to understand how a field that was initially thought of as pseudoscience has come so far, it is instructive to understand its roots in both theory and practice...
January 17, 2018: Experimental Gerontology
S A Bumgardner, Y Zhou, Z Jiang, E J Coe, C L Yakaitis, Y Xiao, R Pazdro
Natural killer (NK) cells are cytotoxic innate lymphocytes that are integral to host defenses against viruses and neoplastic cells. Aging causes phenotypic and functional impairment of NK cells, which diminishes innate immune surveillance, yet the factors that determine the aged NK cell phenotype have not been completely defined. For instance, the genetic basis of the aged NK cell phenotype has not been established, but if determined, could highlight important genetic regulators of NK cells later in life. In this study, we estimated the heritability of splenic NK cell frequencies in aged mice from 15 classical and four wild-derived inbred strains...
January 17, 2018: Experimental Gerontology
Deng-Tai Wen, Lan Zheng, Fan Yang, Han-Zhe Li, Jing Chen
High-Fat-Diet (HFD)-induced obesity is a major contributor to premature senescence in both Drosophila and humans, which includes locomotor impairment, cardiac dysfunction, and decrease in lifespan. While, few studies have shown that HFD could affect the expression dSir2 genes since the dSir2 genes are closely related to aging. As we know, endurance exercise can efficiently prevent obesity and delay age-related functional decline in Drosophila and humans. However, few directed reports showing that exercise can resist HFD-induced locomotor impairment, cardiac dysfunction and decrease in lifespan...
January 16, 2018: Experimental Gerontology
Ji Hyeon Ahn, Joon Ha Park, Jinseu Park, Myoung Cheol Shin, Jun Hwi Cho, In Hye Kim, Jeong-Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Bich Na Shin, Young-Myeong Kim, Choong Hyun Lee, In Koo Hwang, Il Jun Kang, Bai Hui Chen, Bing Chun Yan, Young Joo Lee, Moo-Ho Won, Soo Young Choi
Exercise improves cognitive impairments induced by transient cerebral ischemia and modulates synaptic adhesion molecules. In this study, we investigated effects of long-term treadmill exercise on cognitive impairments and its relation to changes of synaptic cell adhesion molecule (SynCAM) 1/2/3 in the hippocampus after 5 min of transient cerebral ischemia in aged gerbils. Animals were assigned to sedentary and exercised groups, given treadmill exercise for 4 consecutive weeks from 5 days after transient ischemia and evaluated cognitive function through passive avoidance test and Morris water maze test...
January 13, 2018: Experimental Gerontology
Daiki Takagi, Shinya Furukawa, Masahiro Okada, Keiko Tanaka, Hidenori Senba, Masato Teraoka, Hiroyuki Yamada, Naohito Hato, Yoshihiro Miyake
AIMS: Metabolic diseases may affect age-related hearing loss (AHL). Only one epidemiological study showed a positive association between serum uric acid levels and AHL. The aim of this study was to estimate this issue in Japanese men and women. METHODS: Study subjects were 694 individuals aged 36-76 years. A self-administered questionnaire was used to collect information on the variables under study. Audiological assessment was performed using pure-tone audiometry...
January 12, 2018: Experimental Gerontology
Hellen C G Nabuco, Crisieli M Tomeleri, Paulo Junior Sugihara, Rodrigo Dos Reis Fernandes, Edilaine F Cavalcante, Melissa Antunes, Roberto Carlos Burini, Danielle Venturini, Décio S Barbosa, Analiza Mônica Silva, Edilson S Cyrino
BACKGROUND: Metabolic Syndrome (MetS) is an energy-disturbance disease associated with insulin resistance. Hence, the intake of energy-rich macronutrients might affect some MetS components. The aim of this study was to explore the association of ingested macronutrients with MetS components in older women. METHODS: A cross sectional study was conducted in 245 older women (≥60 years). Whole-body dual-energy X-ray absorptiometry was used to assess total body fat, percentage body fat (absolute and relative), and skeletal muscle mass...
January 11, 2018: Experimental Gerontology
Mladen Jergović, Megan J Smithey, Janko Nikolich-Žugich
Aging has a profound effect on the immune system, and both innate and adaptive arms of the immune system show functional decline with age. In response to infection with intracellular microorganisms, old animals mobilize decreased numbers of antigen-specific CD8+ T cells with reduced production of effector molecules and impaired cytolytic activity. However, the CD8+ T cell-intrinsic contribution to, and molecular mechanisms behind, these defects remain unclear. In this review we will discuss the mechanistic contributions of age related changes in the CD8+ T cell pool and the relative roles of intrinsic functional defects in aged CD8+ T cells vs...
January 11, 2018: Experimental Gerontology
Jagadish K Chhetri, Philipe de Souto Barreto, Bertrand Fougère, Yves Rolland, Bruno Vellas, Matteo Cesari
Sarcopenia is characterized by reduced skeletal muscle mass and strength in older individuals. It is one of the leading cause of physical limitation in older adults, and associated with wide spectrum of adverse events including disability and mortality. The phenomenon of chronic-inflammation or inflamm-aging with aging is known to be a major contributor to myriad of geriatric conditions including sarcopenia. Recent advances in regenerative medicine, in particular cell therapy have opened up new possibilities to ameliorate broad range of inflammatory disorders...
January 10, 2018: Experimental Gerontology
Wanitchaya Minta, Siripong Palee, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkum, Sasiwan Kerdpoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
The incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial dynamics are known to play an important role in the maintenance of cardiac physiological function. However, the effects of estrogen deprivation on cardiometabolic status and cardiac mitochondrial dynamics under conditions of obese-insulin resistance have never been investigated. We hypothesized that estrogen deprivation aggravates cardiac dysfunction through increased cardiac mitochondrial fission in obese-insulin resistant rats...
January 10, 2018: Experimental Gerontology
André Bonadias Gadelha, Silvia Gonçalves Ricci Neri, Otávio Toledo Nóbrega, Juscélia Cristina Pereira, Martim Bottaro, Andrew Fonsêca, Ricardo M Lima
No abstract text is available yet for this article.
January 9, 2018: Experimental Gerontology
Tian Yu Wang, Yili Wu, Tong Wang, Yujie Li, Dongfeng Zhang
BACKGROUND: Longitudinal studies on sleep duration and grip strength decline are limited. This study aimed to evaluate the associations of baseline sleep duration with follow-up grip strength and grip strength changeover time among a large sample of middle-aged and older Chinese. METHODS: Data from China Health and Retirement Longitudinal Study, CHARLS (2011-2015), were analyzed. Hand grip strength was measured by dynamometers twice with 4 years interval. Baseline self-reported nighttime sleep duration was collected by questionnaire...
January 9, 2018: Experimental Gerontology
Ciriaco Carru, Mariasole Da Boit, Panagiotis Paliogiannis, Angelo Zinellu, Salvatore Sotgia, Rachael Sibson, Judith R Meakin, Richard M Aspden, Arduino A Mangoni, Stuart R Gray
BACKGROUND: Oxidative stress (OS) negatively affects skeletal muscle homeostasis in experimental models of ageing. However, little is known about the associations between circulating OS markers and parameters of muscle mass and function, and their responses to exercise training, in humans. METHODS: Maximal voluntary contraction (MVC, primary outcome) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross-sectional area (MCSA) and quality (MQ, secondary outcomes), and plasma concentrations of malondialdehyde (MDA, pro-OS), homocysteine (HCY, pro-OS), taurine (TAU, anti-OS), and protein sulphydryl groups (PSH, anti-OS) were measured in 27 healthy older males and 23 females at baseline and after an 18-week resistance exercise program, with or without a nutritional intervention (fish oil vs...
January 8, 2018: Experimental Gerontology
Álvaro Padrón, Vincent Hurez, Harshita B Gupta, Curtis A Clark, Sri Lakshmi Pandeswara, Bin Yuan, Robert S Svatek, Mary Jo Turk, Justin M Drerup, Rong Li, Tyler J Curiel
Cancer immunotherapy has shown remarkable recent progress. Immune checkpoint blocking antibodies have become the most successful anti-cancer agent class ever developed, with six distinct agents approved since 2011 for a wide variety of cancers. Although age is the biggest risk factor for cancer (aside from selected early-onset pediatric cancers), these agents were tested pre-clinically in young hosts, and there is remarkably little published on the effects of host age on treatment outcomes in pre-clinical studies or human clinical trials...
January 8, 2018: Experimental Gerontology
Haritz Arrieta, Chloe Rezola, Idoia Zarrazquin, Iñaki Echeverria, Jose Javier Yanguas, Miren Iturburu, Susana Maria Gil, Ana Rodriguez-Larrad, Jon Irazusta
To investigate the impact of a multicomponent exercise program on anthropometry, physical function, and physical activity on older adults living in long-term nursing homes (LTNH), we conducted a randomized controlled trial involving 112 participants aged 84.9 ± 6.9 years. Participants were randomly assigned to an intervention (IG) or control group (CG). The IG participated in a 3-month multicomponent exercise intervention focused on strength, balance, stretching exercises, and walking recommendations...
January 8, 2018: Experimental Gerontology
Tangmeng Guo, Li Ke, Xiue Zhang, Ling Li, Lijuan Xiong, Bei Cheng
No abstract text is available yet for this article.
January 8, 2018: Experimental Gerontology
Julio Fernandez-Garrido, Vicente Ruiz-Ros, Rut Navarro-Martínez, Cristina Buigues, Mary Martínez-Martínez, Yolanda Verdejo, Laura Sanantonio-Camps, Mª Carmen Mascarós, Omar Cauli
Alteration in the immune system such as the number of white blood cells count (WBC) has been associated with frailty syndrome but their role in institutionalized older individuals have been rarely investigated. We evaluated the relationships between white blood cell subtypes, geriatric assessment, depression and frailty syndrome based on the criteria of physical phenotype. In particular, we aimed to analyze by a two-year follow-up and prospective study the predictive value of alterations in WBC, frailty and functional impairment in terms of hospitalizations and all-cause mortality in institutionalized older women...
January 8, 2018: Experimental Gerontology
Adriane Dallanora Henriques, Andrea Lessa Benedet, Einstein Francisco Camargos, Pedro Rosa-Neto, Otávio Toledo Nóbrega
There is increasing evidence that a number of potentially informative biomarkers for Alzheimer disease (AD) can improve the accuracy of diagnosing this form of dementia, especially when used as a panel of diagnostic assays and interpreted in the context of neuroimaging and clinical data. Moreover, by combining the power of CSF biomarkers with neuroimaging techniques to visualize Aβ deposits (or neurodegenerative lesions), it might be possible to better identify individuals at greatest risk for developing MCI and converting to AD...
January 4, 2018: Experimental Gerontology
Aurélie Le Page, Gilles Dupuis, Anis Larbi, Jacek M Witkowski, Tamas Fülöp
The innate and adaptive branches of the immune system display changes with aging, a fact referred to as immunosenescence. Furthermore, it has been established that adaptive immunity is more susceptible to age-related changes than innate immunity. The most prominent phenotypic changes that reflect the specific differentiation and role of each T cell subpopulation are two-fold. They are a decreased number of naïve T cells that parallels an increase in memory T cells, mainly in the cytotoxic CD8+ T cell population, which can be subdivided into naïve, central, effector memory and TEMRA cells...
January 4, 2018: Experimental Gerontology
Tyler J Loftus, Kolenkode B Kannan, Christy S Carter, Jessica M Plazas, Juan C Mira, Scott C Brakenridge, Christiaan Leeuwenburgh, Philip A Efron, Alicia M Mohr
BACKGROUND: Hypercatecholaminemia and bone marrow dysfunction have been implicated in the pathophysiology of persistent-injury associated anemia. The elderly may be vulnerable to this phenomenon due to high basal and peak catecholamine levels, impaired erythroid progenitor growth, and baseline anemia. We hypothesized that aged F344-BN rats subjected to severe trauma and chronic stress would have persistent injury-associated anemia. METHODS: Male F344-BN rats age 25months were randomly allocated to: naïve (n=8), lung contusion (LC, n=9), LC followed by daily chronic restraint stress (LC/CS, n=9), LC followed immediately by hemorrhagic shock (LCHS, n=8), and LCHS followed by daily CS (LCHS/CS, n=8)...
January 4, 2018: Experimental Gerontology
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