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Experimental Gerontology

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https://www.readbyqxmd.com/read/28528007/luteolin-as-a-potential-preventive-and-therapeutic-candidate-for-alzheimer-s-disease
#1
Youngjoo Kwon
Amyloid cascade hypothesis is the main theoretical framework describing the development of Alzheimer's disease (AD). However, most clinical trials of therapy targeting amyloid-β peptide (Aβ) are unsuccessful because AD is a complex disease involving many genetic and environmental factors. Among various factors, inflammation within the brain in particular has been implicated in the pathogenesis and progression of AD. Furthermore, it has been shown that systemic inflammation can initiate AD. Therefore, anti-inflammatory agents might be beneficial for prevention and/or treatment of AD...
May 17, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28526626/longevity-and-healthy-ageing-genes-foxo3a-and-sirt3-serum-protein-marker-and-new-road-map-to-burst-oxidative-stress-by-withania-somnifera
#2
Rashmita Pradhan, Rahul Kumar, Shashank Shekhar, Nitish Rai, Akash Ambashtha, Joyita Banerjee, Mona Pathak, S N Dwivedi, Sharmistha Dey, Aparajit B Dey
BACKGROUND: Ageing process is characterized by a decline in function; different age related diseases and excessive age associated mortality. There has always been a quest for easily accessible biomarkers to monitor and identify the development of age-associated stress for providing new anti-ageing strategies. Forkhead box protein O3A (FOXO3A) and Sirtuin3 (SIRT3) are such potential markers which plays important role in a wide variety of cellular mechanisms and has been proposed to be an ideal candidate to study longevity and are potential candidate for healthy ageing by oxidative burst...
May 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28526625/effects-of-resistance-training-frequency-on-cardiorespiratory-fitness-in-older-men-and-women-during-intervention-and-follow-up
#3
Elena Fernández-Lezaun, Moritz Schumann, Tuomas Mäkinen, Heikki Kyröläinen, Simon Walker
This study investigated the effects of resistance training (RT) performed with different frequencies, including a follow-up period, on cardiorespiratory fitness in healthy older individuals. Eighty-eight men and women (69±3years, 167±9cm and 78±14kg) were randomly placed into four groups: training one- (M1=11, W1=12), two- (M2=7, W2=14), or three- (M3=11, W3=13) times-per-week or a non-training control group (MCon=11, WCon=9). During months 1-3, all subjects trained two-times-per-week while during the subsequent 6months, training frequency was set according to the group...
May 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28522312/intravascular-imaging-in-cardiovascular-ageing
#4
REVIEW
Christos V Bourantas, Tom Crake, Yao-Jun Zhang, Mick Ozkor, Javed Ahmed, Hector M Garcia-Garcia, Patrick W Serruys
Ageing is related to complex molecular, inflammatory and biochemical changes that affect coronary pathology and often lead to coronary artery disease and cardiovascular events. Intravascular imaging is considered as the ideal technique to study coronary plaque morphology and assess its burden. Over the recent years several studies have been performed that investigated the association between pathophysiological mechanisms that promote vascular ageing and plaque morphology. In addition, several reports have compared plaque pathology in different age groups and a few studies included serial intravascular imaging to assess changes in the atheroma burden and compositional characteristics of the plaque...
May 15, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28511954/high-intensity-interval-training-hiit-improves-resting-blood-pressure-metabolic-met-capacity-and-heart-rate-reserve-without-compromising-resting-myocardial-function-in-sedentary-aging-men
#5
Fergal M Grace, Peter Herbert, Adrian D Elliott, Jo Richards, Alexander Beaumont, Nicholas F Sculthorpe
BACKGROUND: This study examined the combination of pre-conditioning exercise with subsequent high intensity interval training (HIIT) on blood pressure, echocardiography, cardiac strain mechanics and maximal metabolic (MET) capacity in sedentary (SED) aging men compared with age matched masters athletes (LEX). METHODS: Using a STROBE compliant observational design, 39 aging male participants (SED; n=22, aged 62.7±5.2yrs) (LEX; n=17, aged=61.1±5.4yrs) were recruited to a study that necessitated three distinct assessment phases; enrolment (Phase A), following pre-conditioning exercise in SED (Phase B), then following 6weeks of HIIT performed once every five days by both groups before reassessment (Phase C)...
May 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502774/latitudinal-and-age-specific-patterns-of-larval-mortality-in-the-damselfly-lestes-sponsa-senescence-before-maturity
#6
Maciej J Dańko, Aleksandra Dańko, Maria J Golab, Robby Stoks, Szymon Sniegula
Latitudinal differences in life history traits driven by differences in seasonal time constraints have been widely documented. Yet, latitudinal patterns in (age-specific) mortality rates have been poorly studied. Here, we studied latitudinal differences in pre-adult age-specific mortality patterns in the strictly univoltine damselfly Lestes sponsa. We compared individuals from three latitudes reared from the egg stage in the laboratory at temperatures and photoperiods simulating those at the latitude of origin (main experiment) and under common-garden conditions at a fixed temperature and photoperiod (supplementary experiment)...
May 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502773/phosphorylation-of-%C3%AE-b-crystallin-in-the-myocardium-analysis-of-relations-with-aging-and-cardiomyopathy
#7
Natalia A Muraleva, Vasiliy A Devyatkin, Nataliya G Kolosova
Phosphorylation is a major post-translational modification of αB-crystallin (CryaB) and determines this protein's chaperone activity, intracellular distribution, translocation, and cytoprotective functions. Phosphorylation of CryaB manifests itself as either beneficial or deleterious consequences depending on the extent of phosphorylation and interaction with the cytoskeleton. Herein, for the first time, we compared the age-related alterations of the expression and phosphorylation (on Ser59: pS59) of CryaB in the myocardium of Wistar and senescence-accelerated OXYS rats...
May 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502778/the-joint-association-of-insulin-sensitivity-and-physical-activity-on-the-skeletal-muscle-mass-and-performance-in-community-dwelling-older-adults
#8
Chuan-Wei Yang, Chia-Ing Li, Tsai-Chung Li, Chiu-Shong Liu, Chih-Hsueh Lin, Wen-Yuan Lin, Cheng-Chieh Lin
BACKGROUND: Many well-known risk factors that may lead to sarcopenia are already discovered. However, their combined effects on sarcopenia components remain unclear. This study aims to explore the joint association of physical activity and insulin sensitivity on skeletal muscle mass and performance of Taiwanese elder people from a metropolitan community. METHODS: The study sample involved 844 elders who were examined through dual energy X-ray absorptiometry and who underwent tests for fasting blood glucose and serum insulin level...
May 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502777/peripheral-muscle-fatigue-in-hospitalised-geriatric-patients-is-associated-with-circulating-markers-of-inflammation
#9
Pauline Arnold, Rose Njemini, Stijn Vantieghem, Jacques Duchateau, Tony Mets, Ingo Beyer, Ivan Bautmans
Geriatric patients with acute infection show increased muscle weakness and fatigability but the relative contribution of central and peripheral factors is unclear. Hospitalised patients with acute infection (82±6years, N=10) and community-dwelling controls (76±6years, N=19) sustained a maximal voluntary isometric contraction of the M. Adductor Pollicis until strength dropped to 50% of its maximal value. Voluntary muscle activation (VA) was assessed before and at the end of the fatigue protocol using twitch interpolation method and muscle activity was monitored using surface electromyography...
May 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28502776/dried-plum-and-chokeberry-ameliorate-d-galactose-induced-aging-in-mice-by-regulation-of-pl3k-akt-mediated-nrf2-and-nf-kb-pathways
#10
Heesoo Jeong, Yanan Liu, Hyun-Sook Kim
No abstract text is available yet for this article.
May 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28499954/systematic-review-and-meta-analysis-of-gait-mechanics-in-young-and-older-adults
#11
Katherine A Boyer, Russell T Johnson, Jacob J Banks, Carl Jewell, Jocelyn F Hafer
BACKGROUND: Age-related gait changes may play a critical role in functional limitations of older adults. Despite sizable interest in determining how age alters walking mechanics, small sample sizes and varied outcome measures have precluded a comprehensive understanding of the impact of age on lower extremity joint kinematics and kinetics. OBJECTIVE: The aim of this study was to perform a systematic review and meta-analysis of the aging gait mechanics literature...
May 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28479389/involvement-of-progranulin-in-modulating-neuroinflammatory-responses-but-not-neurogenesis-in-the-hippocampus-of-aged-mice
#12
Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara
It is well established that adult neurogenesis in the hippocampus declines with age. Our previous studies have suggested that progranulin (PGRN) has a facilitative effect on hippocampal neurogenesis. We have also shown that PGRN plays a role in suppressing excessive neuroinflammatory responses in the cortex and thalamus after brain injury and aging, respectively. However, the roles of PGRN in modulating neurogenesis and neuroinflammatory responses in the hippocampus of aged animals are not yet understood. In the present study, we investigated neurogenesis and neuroinflammation-related responses in the hippocampus of young (15-week-old) and old (135-week-old) wild-type and PGRN-deficient male mice...
May 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28479388/acceleration-based-training-a-new-mode-of-training-in-senescent-rats-improving-performance-and-left-ventricular-and-muscle-functions
#13
Thierry Launay, Iman Momken, Serge Carreira, Nathalie Mougenot, Xian-Long Zhou, Leanne De Koning, Romain Niel, Bruno Riou, Véronique Billat, Sophie Besse
High intensity training (HIT) has been shown to improve maximal aerobic capacity and muscle protein synthesis but has not yet been investigated in senescent rats. We hypothesized that the change of speed (acceleration) during each bout of HIT acts as a stimulus responsible for the adaptations of the organism to exercise. Twenty two month-old (mo) rats (n=14) were subjected to a short acceleration protocol (20-30min) of exercise, comprising 3 independent bouts of acceleration and compared to an age-matched sedentary group (n=14)...
May 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28476585/cd4-cd8-ratio-1-is-associated-with-lymphocyte-subsets-cmv-and-gender-in-71-year-old-individuals-5-year-follow-up-of-the-swedish-hexa-immune-longitudinal-study
#14
Jan Strindhall, Sture Löfgren, Caroline Främsth, Andreas Matussek, Malin Bengner, Jan Ernerudh, Anders Wikby
No abstract text is available yet for this article.
May 2, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28476584/validity-of-the-international-fitness-scale-ifis-in-older-adults
#15
Eugenio Merellano-Navarro, Daniel Collado-Mateo, Javier García-Rubio, Narcís Gusi, Pedro R Olivares
OBJECTIVE: To validate the "International Fitness Scale" (IFIS) in older adults. METHODS: Firstly, cognitive interviews were performed to ensure that the questionnaire was comprehensive for older Chilean adults. After that, a transversal study of 401 institutionalized and non-institutionalized older adults from Maule region in Chile was conducted. A battery of validated fitness tests for this population was used in order to compare the responses obtained in the IFIS with the objectively measured fitness performance (back scratch, chair sit-and-reach, handgrip, 30-s chair stand, timed up-and-go and 6-min walking)...
May 2, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28465043/impact-of-age-and-cytomegalovirus-on-cd8-t-cell-compartment-remodeling-after-solid-organ-transplantation-a-one-year-follow-up-study
#16
Sara Cantisán, Aurora Páez-Vega, Francisco Santos, Alberto Rodríguez-Benot, Rocío Aguado, Antonio Rivero, Miguel Montejo, Julián Torre-Cisneros, Rafael Solana
Cytomegalovirus (CMV), a member of the β-herpesvirus family, is a major complicating infection in transplant patients. CMV latency has a long-term impact on CD8(+) T-cell differentiation. It is unclear, however, whether this effects can be detected in one-year period. To investigate this we analyzed the remodeling of the CD8(+) T-cell compartment during the first year after solid organ transplantation. A total of 55 kidney or lung transplant patients were recruited. CD8(+) T-cell subsets were prospectively analyzed at pretransplant, at 3 or 6months and 12months after transplantation (mo post-Tx)...
April 29, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28461078/isolation-and-identification-of-senescent-renal-tubular-epithelial-cells-using-immunomagnetic-beads-based-on-dcr2
#17
Jia Chen, Ke-Hong Chen, Bi-Qiong Fu, Weiwei Zhang, Huanzi Dai, Li-Rong Lin, Li-Ming Wang, Ya-Ni He
Cell senescence plays a major role in the progression of tumors and chronic conditions such as diabetes and chronic kidney disease. Senescent cells are an important model for the study of aging-related diseases, and there is currently no efficient method for sorting out senescent cells. Decoy receptor 2 (DcR2) is a transmembrane receptor of the tumor necrosis factor superfamily, which is specifically expressed in senescent cells. In this study, we used magnetic activated cell sorting (MACS) isolation of a highly-pure populations DcR2-positive renal tubular epithelial cells (RTECs) based on three senescent cell models including the fifth passage cells, advanced glycation end-products (AGEs)- and H2O2-induced cells...
April 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28457986/metabolome-analysis-of-effect-of-aspirin-on-drosophila-lifespan-extension
#18
Chaochun Song, Chenxing Zhu, Qi Wu, Jiancheng Qi, Yue Gao, Zhichao Zhang, Uma Gaur, Deying Yang, Xiaolan Fan, Mingyao Yang
Effective approaches for drug development involve the repurposing of existing drugs which are already approved by the FDA. Aspirin has been shown to have many health benefits since its discovery as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Recent experiments demonstrated the longevity effects of aspirin in Drosophila, but its mechanism remains to be explored. In order to elucidate the effects of drug on metabolism, we carried out the metabolic analysis of aspirin-treated flies...
April 27, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28450241/regulatory-effects-of-galanin-system-on-development-of-several-age-related-chronic-diseases
#19
REVIEW
Penghua Fang, Mei Yu, Dang Wan, Lei Zhang, Long Han, Zhongqi Shen, Mingyi Shi, Yan Zhu, Zhenwen Zhang, Ping Bo
Age is a major risk factor for developing chronic diseases, including type 2 diabetes, depression and Alzheimer's disease. The rapidly increase in the morbidity of these age-related chronic diseases is becoming a global problem. Although our understanding of these age-related diseases has tremendously been improved in recent years, certain aspects of their etiology and relative regulatory factors still remain elusive to clinicians and researchers. Emerging evidences suggest that neuropeptide galanin is involved in the pathogenesis of type 2 diabetes, depression and Alzheimer's disease...
April 24, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28442382/relationship-between-sensorimotor-peripheral-nerve-function-and-indicators-of-cardiovascular-autonomic-function-in-older-adults-from-the-health-aging-and-body-composition-study
#20
Brittney S Lange-Maia, Anne B Newman, John M Jakicic, Jane A Cauley, Robert M Boudreau, Ann V Schwartz, Eleanor M Simonsick, Suzanne Satterfield, Aaron I Vinik, Sasa Zivkovic, Tamara B Harris, Elsa S Strotmeyer
BACKGROUND: Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. METHODS: Health, Aging and Body Composition participants (n=2399, age=76.5±2.9years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit...
April 22, 2017: Experimental Gerontology
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