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Experimental Gerontology

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https://www.readbyqxmd.com/read/29146475/electrical-activity-of-sensory-pathways-in-female-and-male-geriatric-rhesus-monkeys-macaca-mulatta-and-its-relation-to-oxidative-stress
#1
A Ibáñez-Contreras, U Hernández-Arciga, A Poblano, M Arteaga-Silva, B Hernández-Godínez, G I Mendoza-Cuevas, R Toledo-Pérez, A Alarcón-Aguilar, V Y González-Puertos, M Konigsberg
Synapses loss during aging has been related to decreased neuronal excitability and reduced electrophysiological activity in the nervous system, as well as to increased brain damage. Those physiological and biochemical alterations have been related to the oxidative stress increase associated with old age. The main substrate of lipid peroxidation (LPX) in the central and peripheral nervous systems are the myelin sheaths, and their damage generates a delayed nerve conduction velocity. However, studies in which the neural conduction velocity is related to changes in the redox state are still lacking...
November 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29137947/low-dose-vitamin-d-supplementation-and-incident-frailty-in-older-people-an-eight-year-longitudinal-study
#2
Francesco Bolzetta, Brendon Stubbs, Marianna Noale, Alberto Vaona, Jacopo Demurtas, Stefano Celotto, Alberto Cester, Stefania Maggi, Ai Koyanagi, Emanuele Cereda, Nicola Veronese
Hypovitaminosis D is associated with frailty, but if vitamin D supplementation may prevent the onset of frailty is poorly known. Therefore, we aimed to investigate whether vitamin D supplementation is associated with a lower risk of frailty. In this longitudinal study, 4,421 individuals at high risk or having knee osteoarthritis free from frailty at baseline (mean age: 61.3, females=58.0%) were followed for 8 years. Details regarding vitamin D supplementation were captured by asking whether the participant took vitamin D during the previous year, at least once per month...
November 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29133011/aging-affects-the-response-of-female-rats-to-a-hypercaloric-diet
#3
B D Arbo, G Niches, P Zanini, D M Bassuino, D Driemeier, M F Ribeiro, A L Cecconello
Metabolic syndrome is a major risk factor for the development of cardiovascular diseases and diabetes, among other conditions. Studies have shown that aging and metabolic syndrome share several metabolic alterations, and that aged individuals, in particular females, are at an increased risk of developing metabolic disorders. Although several studies have investigated the effects of hypercaloric diets in the development of obesity and metabolic syndrome in young animals, few studies have investigated these parameters in aged animals, especially in females...
November 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29129737/endotoxemia-is-modulated-by-quantity-and-quality-of-dietary-fat-in-older-adults
#4
Javier Lopez-Moreno, Sonia Garcia-Carpintero, Francisco Gomez-Delgado, Rosa Jimenez-Lucena, Cristina Vals-Delgado, Juan F Alcala-Diaz, Irene Roncero-Ramos, Oriol A Rangel-Zuñiga, Elena M Yubero-Serrano, Maria M Malagon, Jose M Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda, Antonio Camargo
BACKGROUND: Aging is an important determinant of the rate of atherosclerosis development, mainly through low-grade inflammation. Diet, and particularly its fat content, modulates the inflammatory response in fasting and postprandial states. OBJECTIVE: We aimed to study the effects of dietary fat on endotoxemia in healthy older adults. MATERIALS AND METHODS: Twenty healthy older adults were randomized to three diets, lasting three-weeks each, using a crossover design: 1...
November 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29129736/role-of-d-galactose-induced-brain-aging-and-its-potential-used-for-therapeutic-interventions
#5
REVIEW
Thazin-Shwe, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakorn
Aging is a phenomenon that all living organisms inevitably face. Every year, 9.9million people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is significantly associated with mitochondrial dysfunction. This is characterized by a decrease in the activity of respiratory chain enzymes and ATP production, and increased free radical generation, mitochondrial deoxyribonucleic acid (DNA) mutations, and impaired mitochondrial structures. To get a better understanding of aging and to prevent its effects on many organs, chronic systemic administration of D-galactose was used to artificially create brain senescence in animal models and established to be beneficial for studies of anti-aging therapeutic interventions...
November 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29129735/arterial-stiffness-and-cerebral-hemodynamic-pulsatility-during-cognitive-engagement-in-younger-and-older-adults
#6
Kevin S Heffernan, Jacqueline A Augustine, Wesley K Lefferts, Nicole L Spartano, William E Hughes, Randall S Jorgensen, Brooks B Gump
This study examined central artery stiffness and hemodynamic pulsatility during cognitive engagement in younger and older adults. METHODS: Vascular-hemodynamic measures were completed in 19 younger (age 35±1yrs) and 20 older (age 69±2yrs) adults at rest and during a Stroop task. Aortic stiffness (carotid-femoral pulse wave velocity, PWV) and carotid pulse pressure (PP) were assessed using applanation tonometry. Carotid stiffness was assessed as a single-point PWV using Doppler Ultrasound...
November 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29128575/strain-specificities-in-age-related-changes-in-mechanisms-promoting-and-controlling-rat-spinal-cord-damage-in-experimental-autoimmune-encephalomyelitis
#7
Zorica Stojić-Vukanić, Ivan Pilipović, Jasmina Djikić, Ivana Vujnović, Mirjana Nacka-Aleksić, Biljana Bufan, Nevena Arsenović-Ranin, Duško Kosec, Gordana Leposavić
The study investigated strain specificities in age-related differences in CD8+ T cell- and microglial cell-mediated mechanisms implicated in induction/perpetuation and/or control of neuroinflammation in experimental autoimmune encephalomyelitis (EAE) in Albino Oxford (AO) and Dark Agouti (DA) rats exhibiting age-related changes in the susceptibility to EAE in the opposite direction (increase in relatively resistant AO rats vs decrease in DA rats). In the inductive phase of EAE, the greater number of fully differentiated effector CD8+ T lymphocytes was found in draining lymph nodes (dLNs) from aged rats of both strains than in strain-matched young rats, but this was particularly prominent in AO rats, which exhibited milder EAE of prolonged duration compared with their DA counterparts...
November 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29101015/dna-damage-metabolism-and-aging-in-pro-inflammatory-t-cells-rheumatoid-arthritis-as-a-model-system
#8
REVIEW
Yinyin Li, Jörg J Goronzy, Cornelia M Weyand
The aging process is the major driver of morbidity and mortality, steeply increasing the risk to succumb to cancer, cardiovascular disease, infection and neurodegeneration. Inflammation is a common denominator in age-related pathologies, identifying the immune system as a gatekeeper in aging overall. Among immune cells, T cells are long-lived and exposed to intense replication pressure, making them sensitive to aging-related abnormalities. In successful T cell aging, numbers of naïve cells, repertoire diversity and activation thresholds are preserved as long as possible; in maladaptive T cell aging, protective T cell functions decline and pro-inflammatory effector cells are enriched...
November 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29104092/mild-cognitive-impairment-and-physical-activity-in-the-general-population-findings-from-six-low-and-middle-income-countries
#9
Davy Vancampfort, Brendon Stubbs, Elvira Lara, Mathieu Vandenbulcke, Nathalie Swinnen, Ai Koyanagi
INTRODUCTION: Despite the beneficial effects of physical activity (PA) for people with mild cognitive impairment (MCI) on cognition and the acknowledgement that MCI is a critical period for intervening to prevent dementia, little is known about the actual PA levels in people with MCI. This study investigates the relationship between MCI and compliance with PA recommendations. METHODS: Cross-sectional data from the World Health Organization's Study on Global Ageing and Adult Health (China, Ghana, India, Mexico, Russia, South Africa) (n=32,715; mean age=62...
November 6, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29113752/region-specific-glial-hyperplasia-and-neuronal-stability-of-rat-lateral-geniculate-nucleus-during-aging
#10
Felipe P Fiuza, Antônio Carlos Q Aquino, Diego A Câmara, José Rodolfo L P Cavalcanti, Expedito S Nascimento Júnior, Ramon H Lima, Rovena Clara G J Engelberth, Jeferson S Cavalcante
The normal aging process is accompanied by functional declines in image-forming and non-image forming visual systems. Among the components of these systems, the thalamic lateral geniculate nucleus (LGN) offers a good model for aging studies since its three anatomical subdivisions, namely dorsal lateral geniculate nucleus (dLGN), intergeniculate leaflet (IGL) and ventral lateral geniculate nucleus (vLGN), receives light information from retina and projects to different brain areas involved in visual-related functions...
November 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29107062/the-anti-aging-protein-klotho-alleviates-injury-of-nigrostriatal-dopaminergic-pathway-in-6-hydroxydopamine-rat-model-of-parkinson-s-disease-involvement-of-pka-camkii-creb-signaling
#11
Tourandokht Baluchnejadmojarad, Seyed-Mohammad Eftekhari, Nida Jamali-Raeufy, Sobhan Haghani, Hossein Zeinali, Mehrdad Roghani
Parkinson's disease (PD) is a prevalent movement disorder in the elderly. PD is hallmarked with progressive deterioration of mesencephalic dopaminergic neurons and development of debilitating motor and non-motor clinical symptoms. Klotho protein is the product of an aging-suppressor gene that its overexpression could protect neurons against oxidative injury. This study was undertaken to explore whether exogenous klotho could alleviate injury of nigrostriatal dopaminergic pathway in 6-hydroxydopamine (6-OHDA) rat model of PD...
October 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29107061/physical-activity-and-physical-fitness-of-nursing-home-residents-with-cognitive-impairment-a-pilot-study
#12
José Marmeleira, Soraia Ferreira, Armando Raimundo
Physical activity and physical fitness are important for health, functional mobility and performance of everyday activities. To date, little attention has been given to physical activity and physical fitness among nursing home residents with cognitive impairment. Therefore, the main aim of this study was to examine physical activity behavior and physical fitness of institutionalized older adults with cognitive impairment and to investigate their interrelations. Forty-eight older adults with cognitive impairment (83...
October 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29101014/integrin-linked-kinase-a-new-actor-in-the-ageing-process
#13
Gemma Olmos, Susana López-Ongil, Maria Piedad Ruiz Torres
Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors...
October 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29111233/age-and-immunity-what-is-immunosenescence
#14
REVIEW
Graham Pawelec
As is apparent from the many contributions to this Special Issue of the Journal, the impact of age on immunity is nefarious, with all manner of dysregulated responses attributed to "immunosenescence". These range from poorer responses to vaccination, lower capacity to mediate anti-cancer responses, more inflammation and tissue damage, along with autoimmunity and loss of control of persistent infections. Given the grave clinical implications of altered immune status in aged people, it is of paramount importance to understand the nature of and mechanisms responsible for "immunosenescence"...
October 27, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29107063/hidden-heterogeneity-in-alzheimer-s-disease-insights-from-genetic-association-studies-and-other-analyses
#15
Anatoliy I Yashin, Fang Fang, Mikhail Kovtun, Deqing Wu, Matt Duan, Konstantin Arbeev, Igor Akushevich, Alexander Kulminski, Irina Culminskaya, Ilya Zhbannikov, Arseniy Yashkin, Eric Stallard, Svetlana Ukraintseva
Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet available. The reasons are likely to be the fact that AD is a multifactorial and heterogeneous health disorder with multiple alternative pathways of disease development and progression. The availability of genetic data on individuals participated in longitudinal studies of aging health and longevity, as well as on participants of cross-sectional case-control studies allow for investigating genetic and non-genetic connections with AD and to link the results of these analyses with research findings obtained in clinical, experimental, and molecular biological studies of this health disorder...
October 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29080833/age-related-immune-responses-after-burn-and-inhalation-injury-are-associated-with-altered-clinical-outcomes
#16
John H Frankel, Devin M Boe, Joslyn M Albright, Eileen B O'Halloran, Stewart R Carter, Christopher S Davis, Luis Ramirez, Ellen L Burnham, Richard L Gamelli, Majid Afshar, Elizabeth J Kovacs
This prospective study aimed to address changes in inflammatory response between different aged populations of patients who sustained burn and inhalation injury. Plasma and bronchoalveolar lavage (BAL) samples were collected from 104 patients within 15h of their estimated time of burn injury. Clinical variables, laboratory parameters, and immune mediator profiles were examined in association with clinical outcomes. Older patients were at higher odds for death after burn injury (odds ratio (OR)=7.37 per 10years, p=0...
October 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29079145/nrf2-mediated-neuroprotection-by-manf-against-6-ohda-induced-cell-damage-via-pi3k-akt-gsk3%C3%AE-pathway
#17
Jingxing Zhang, Weifang Tong, Hui Sun, Ming Jiang, Yijue Shen, Yigang Liu, Hua Gu, Jia Guo, Jianmin Fang, Lingjing Jin
Oxidative stress and apoptosis are thought to be broadly involved in the pathogenesis of Parkinson's disease. We previously reported that Mesencephalic astrocyte-derived neurotrophic factor (MANF) possesses anti-oxidation and anti-apoptotic effects against 6-OHDA-induced neurotoxicity, but the specific molecular mechanism remains unclear. In this study, we showed that MANF up-regulates the expression of nuclear factor erythroid 2-related factor (Nrf2) and promotes its translocation into the nucleus. The anti-oxidation and anti-apoptotic effects of MANF could be partially blocked by inhibitor or shRNA-mediated knockdown of Nrf2...
October 25, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29074290/epigenetic-effects-of-physical-activity-in-elderly-patients-with-cardiovascular-disease
#18
REVIEW
Rina Recchioni, Fiorella Marcheselli, Roberto Antonicelli, Emanuela Mensà, Raffaella Lazzarini, Antonio Domenico Procopio, Fabiola Olivieri
Cardiovascular disease (CVD) is an important public health problem affecting especially the elderly. Over the past 20years, an increasing number of studies have examined its underlying pathophysiological mechanisms and new therapies are continually being discovered. However, despite considerable progress in CVD management, mortality and morbidity remain a major healthcare concern, and frequent hospital admissions compromise the daily life and social activities of these patients. Physical activity has emerged as an important non-pharmacological adjunctive therapy for CVD in older patients, especially for heart failure patients, exerting its beneficial effects on mortality, morbidity, and functional capacity...
October 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29066418/beneficial-effects-of-resistance-training-on-the-protein-profile-of-the-calcaneal-tendon-during-aging
#19
Fabrício R Barin, João Luiz Q Durigan, Kléber de S Oliveira, Ludovico Migliolo, Jeeser Alves Almeida, Marcia Carvalho, Bernardo Petriz, Heloisa Sobreiro Selistre-de-Araujo, Wagner Fontes, Octavio L Franco, Rita de C Marqueti
The calcaneal tendon (CT) is the most commonly injured tendon in the human body. Moreover, with advancing age, the amount of damage increases further. Resistance training (RT) could be used to minimize such damages. The aim of the present study was to obtain the identification, detailed protein cataloging and biochemical characterization based on the effects of the aging process and the RT in CT of rats. The analysis by liquid chromatography tandem-mass spectrometry showed 142 distinct proteins, however, only 29 proteins met the inclusion criteria and were analyzed...
October 21, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29056555/the-effect-of-arc-ablation-on-skeletal-muscle-morphology-function-and-apoptotic-signaling-during-aging
#20
Kira Vorobej, Andrew S Mitchell, Ian C Smith, Stefan Donath, A Russell Tupling, Joe Quadrilatero
Augmented apoptotic signaling can result in degradation of skeletal muscle proteins and loss of myonuclei, ultimately contributing to muscle atrophy and contractile dysfunction. Apoptosis repressor with caspase recruitment domain (ARC) is an anti-apoptotic protein highly expressed in skeletal muscle. Here we examined the role of ARC on age-related skeletal muscle apoptosis and wasting by utilizing an ARC-deficient mouse model. Aged mice displayed a number of morphological, phenotypic, and contractile alterations in both soleus and plantaris muscle with aging...
October 19, 2017: Experimental Gerontology
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