Md Rezaul Islam, Shopnil Akash, Mohammed Murshedul Islam, Nadia Sarkar, Ajoy Kumer, Sandip Chakraborty, Kuldeep Dhama, Majed Ahmed Al-Shaeri, Yasir Anwar, Polrat Wilairatana, Abdur Rauf, Ibrahim F Halawani, Fuad M Alzahrani, Haroon Khan
Alzheimer's disease (AD) has few effective treatment options and continues to be a major global health concern. AD is a neurodegenerative disease that typically affects elderly people. Alkaloids have potential sources for novel drug discovery due to their diverse chemical structures and pharmacological activities. Alkaloids, natural products with heterocyclic nitrogen-containing structures, are considered potential treatments for AD. This review explores the neuroprotective properties of alkaloids in AD, focusing on their ability to regulate pathways such as amyloid-beta aggregation, oxidative stress, synaptic dysfunction, tau hyperphosphorylation, and neuroinflammation...
April 4, 2024: Brain Research