journal
MENU ▼
Read by QxMD icon Read
search

Brain Research

journal
https://www.readbyqxmd.com/read/28442243/abnormal-neural-precursor-cell-regulation-in-the-early-postnatal-fragile-x-mouse-hippocampus
#1
Mary Sourial, Laurie C Doering
The regulation of neural precursor cells (NPCs) is indispensable for a properly functioning brain. Abnormalities in NPC proliferation, differentiation, survival, or integration have been linked to various neurological diseases including Fragile X syndrome. Yet, no studies have examined NPCs from the early postnatal Fragile X mouse hippocampus despite the importance of this developmental time point, which marks the highest expression level of FMRP, the protein missing in Fragile X, in the rodent hippocampus and is when hippocampal NPCs have migrated to the dentate gyrus (DG) to give rise to lifelong neurogenesis...
April 22, 2017: Brain Research
https://www.readbyqxmd.com/read/28438532/kinetic-properties-and-adrenergic-control-of-trek-2-like-channels-in-rat-medial-prefrontal-cortex-mpfc-pyramidal-neurons
#2
W Ładno, M Gawlak, P Szulczyk, E Nurowska
TREK-2-like channels were identified on the basis of electrophysiological and pharmacological tests performed on freshly isolated and enzymatically/mechanically dispersed pyramidal neurons of the rat medial prefrontal cortex (mPFC). Single-channel currents were recorded in cell-attached configuration and the impact of adrenergic receptors (α1, α2, β) stimulation on spontaneously appearing TREK-2-like channel activity was tested. The obtained results indicate that noradrenaline decreases the mean open probability of TREK-2-like channel currents by activation of β1 but not of α1- and α2-adrenergic receptors...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28438531/altered-gray-and-white-matter-microstructure-in-cushing-s-disease-a-diffusional-kurtosis-imaging-study
#3
Hong Jiang, Na-Ying He, Yu-Hao Sun, Fang-Fang Jian, Liu-Guan Bian, Jian-Kang Shen, Fu-Hua Yan, Si-Jian Pan, Qing-Fang Sun
Exposure to chronic hypercortisolism has multiple adverse effects on brain biology in humans. Cushing's disease (CD) represents a unique and natural human model for examining the effects of hypercortisolism on the brain. This cross-sectional study used Diffusional Kurtosis Imaging (DKI) to investigate the microstructure alterations in both white matter (WM) and gray matter (GM) of CD patients and to determine the relationship of these changes with clinical characteristics. DKI images were obtained from 15 active CD patients...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28438530/ferulic-acid-attenuates-brain-microvascular-endothelial-cells-damage-caused-by-oxygen-glucose-deprivation-via-punctate-mitochondria-dependent-mitophagy
#4
Jun-Li Chen, Wen-Jun Duan, Si Luo, Shi Li, Xiao-Hui Ma, Bo-Nan Hou, Shu-Yi Cheng, Shu-Huan Fang, Qi Wang, Shui-Qing Huang, Yun-Bo Chen
Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial cells (BMECs) which underwent oxygen-glucose deprivation (OGD) for 2 hours. Our data showed that FA significantly reversed the oxidative stress state of OGD-treated BMECs and reduced mitochondrial dysfunction...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28438529/an-erp-investigation-of-vertical-reading-fluency-in-scrabble-%C3%A2-experts
#5
Sophia van Hees, Sabine Seyffarth, Penny M Pexman, Filomeno Cortese, Andrea B Protzner
Previous studies have found that competitive Scrabble expertise is associated with enhanced performance on visual lexical decision tasks (LDT), particularly for vertically presented stimuli. In the current study, we investigated the underlying mechanisms responsible for this vertical fluency. We examined behaviour and neural activity during LDT in 19 competitive Scrabble players and 18 matched controls. Using event related potentials (ERP), we investigated whether Scrabble expertise modulates the N170, P300, and late positive component (LPC), associated with visual-orthographic processing, working memory, and stimulus classification, respectively...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28435085/adolescent-changes-in-hindbrain-noradrenergic-a2-neurons-in-male-rats
#6
Laurie Pham, Madelyn R Baker, Ziasmin Shahanoor, Russell D Romeo
During adolescence, the increased susceptibility to stress-related dysfunctions (e.g., anxiety, drug use, obesity) may be influenced by changes in the hormonal stress response mediated by the hypothalamic-pituitary-adrenal (HPA) axis. We have previously reported that restraint stress leads to significantly prolonged HPA responses in pre-adolescent compared to adult rats. Further, pre-adolescent animals exposed to restraint show greater levels of neural activation than adults in the paraventricular nucleus of the hypothalamus (PVN), a key nucleus integrating information from brain regions that coordinate HPA responses...
April 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28435084/optimization-of-behavioural-tests-for-the-prediction-of-outcomes-in-mouse-models-of-focal-middle-cerebral-artery-occlusion
#7
Zhuoyu Wen, Xiaomeng Xu, Lili Xu, Lian Yang, Xiaohui Xu, Juehu A Zhu, Li Wu, Yongjun Jiang, Xinfeng Liu
Intraluminal middle cerebral artery occlusion (MCAO) is the most widely used model of stroke. We aimed to predict the outcome of MCAO using a combination of fine behavioural tests for the prediction of unsuccessful surgery in mice leading to no infarction, haemorrhage and unexpected death. MCAO was performed on adult mice under the guidance of laser-Doppler flowmetry (LDF) to warrant a decrease in regional cerebral blood flow (rCBF) in the MCA territory. Four outcomes of MCAO were defined according to histological analysis: infarction, no infarction, haemorrhage and unexpected death (death within 24 h post-surgery)...
April 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28435083/subchronic-glucocorticoids-glutathione-depletion-and-a-postpartum-model-elevate-monoamine-oxidase-a-activity-in-the-prefrontal-cortex-of-rats
#8
Sofia Raitsin, Junchao Tong, Stephen Kish, Xin Xu, Lilia Magomedova, Carolyn Cummins, Ana C Andreazza, Gustavo Scola, Glen Baker, Jeffrey H Meyer
Recent human brain imaging studies implicate dysregulation of monoamine oxidase-A (MAO-A), in particular in the prefrontal cortex (PFC) and anterior cingulate cortex (ACC), in the development of major depressive disorder (MDD). This study investigates the influence of four alterations underlying important pathologies of MDD, namely, chronic elevation of glucocorticoid levels, glutathione depletion, changes in female gonadal sex hormones and serotonin concentration fluctuation, on MAO-A and MAO-B activity in rats...
April 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28427869/ischemic-preconditioning-with-ketogenic-diet-improves-brain-ischemic-tolerance-through-increased-extracellular-adenosine-levels-and-hypoxia-inducible-factors
#9
Qi Yang, Min Guo, Xun Wang, Yanxin Zhao, Hongyan Ding, Mei Cui, Qiang Dong
Achieving a prolonged neuroprotective state reduces brain damage and neurological dysfunction characteristic of brain ischemia. The ketogenic diet (KD) has disease-modifying effects in several neurodegenerative disorders. In this study, we fed mice with KD for three weeks and performed reversible middle cerebral artery occlusion (MCAO) in the animals. KD-fed mice had significantly reduced infarct volume, increased regional cerebral blood flow (rCBF) and extracellular adenosine levels in both ischemic and reperfusion stages...
April 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28414034/age-exacerbates-surgery-induced-cognitive-impairment-and-neuroinflammation-in-sprague-dawley-rats-the-role-of-il-4
#10
Zhe Li, Fang Liu, Hong Ma, Paul F White, Roya Yumul, Yanhua Jiang, Na Wang, Xuezhao Cao
Age is the most prominent risk factor for the development of postoperative cognitive dysfunction. This study investigated the potential role of anti-inflammatory interleukin (IL)-4 in age-related differences of surgery-induced cognitive deficits and neuroinflammatory responses. Both adult and aged Sprague-Dawley male rats were subjected to partial hepatectomy or partial hepatectomy with a cisterna magna infusion of IL-4. On postoperative days 1, 3, and 7, the rats were subjected to a reversed Morris water maze test...
April 14, 2017: Brain Research
https://www.readbyqxmd.com/read/28411086/early-depletion-of-ca1-neurons-and-late-neurodegeneration-in-a-mouse-tauopathy-model
#11
Lone Helboe, Jan Egebjerg, Pernille Barkholt, Christiane Volbracht
Alzheimer's disease (AD) and tauopathies, such as frontotemporal dementia (FTD), are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau. Further neuropathological characteristics include synaptic loss, neurodegeneration and brain atrophy. Here, we explored the association between hyperphosphorylated tau species, brain atrophy, synaptic and neuronal loss in a mouse model (rTg4510) carrying the human tau (hTau) P301L mutation found in a familiar form of FTD. We established that hTau expression during the first 6 postnatal weeks was important for the progression of tauopathy in rTg4510 mice...
April 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28404451/anandamide-and-2-ag-are-endogenously-present-within-the-laterodorsal-tegmental-nucleus-functional-implications-for-a-role-of-ecbs-in-arousal
#12
Neeraj Soni, Bala Krishna Prabhala, Ved Mehta, Osman Mirza, Kristi Anne Kohlmeier
Previously, we presented electrophysiological evidence for presence in mice brain slices of functional cannabinoid type I receptors (CB1Rs) within the laterodorsal tegmentum (LDT), a brain stem nucleus critical in control of arousal and rapid eye movement (REM) sleep. Further, using pharmacological agents, we provided data suggestive of the endogenous presence of cannabinoids (CBs) acting at LDT CB1Rs. However, in those studies, we were unable to identify the type(s) of CB ligands endogenously present in the LDT, and this information has not been provided elsewhere...
April 9, 2017: Brain Research
https://www.readbyqxmd.com/read/28396009/molecular-mechanisms-of-brain-derived-neurotrophic-factor-in-neuro-protection-recent-developments
#13
REVIEW
Hailin Zhao, Azeem Alam, Chun-Yin San, Shiori Eguchi, Qian Chen, Qingquan Lian, Daqing Ma
Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury...
April 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28389236/visual-stimuli-approaching-toward-the-body-influence-temporal-expectations-about-subsequent-somatosensory-stimuli
#14
Tsukasa Kimura, Jun'ichi Katayama
The present study investigated whether visual stimuli approaching the body influence temporal expectations about subsequent somatosensory stimuli. To examine this question, we recorded event-related brain potentials (ERPs) during a simple reaction time task using somatosensory stimuli. Fourteen participants were asked to place their arms on a desk, and three light-emitting diodes (LEDs) were placed at equal distances between their arms. Each trial was composed of three visual stimuli (i.e., LEDs), and one subsequent electrical stimulus (i...
April 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28377160/increased-visual-task-difficulty-enhances-attentional-capture-by-both-visual-and-auditory-distractor-stimuli
#15
Fumie Sugimoto, Jun'ichi Katayama
Previous studies using a three-stimulus oddball task have shown the amplitude of P3a elicited by distractor stimuli increases when perceptual discrimination between standard and target stimuli becomes difficult. This means that the attentional capture by the distractor stimuli is enhanced along with an increase in task difficulty. So far, the increase of P3a has been reported when standard, target, and distractor stimuli were presented within one sensory modality (i.e., visual or auditory). In the present study, we further investigated whether or not the increase of P3a can also be observed when the distractor stimuli are presented in a different modality from the standard and target stimuli...
April 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28377159/reorganization-of-the-thalamocortical-network-in-musicians
#16
Shoji Tanaka, Eiji Kirino
The cortico-thalamocortical network is relevant to music performance in that the network can regulate sensitivity to afferent input or sound, mediate the integration of multimodal information required for the performance, and play a role in skilled performance control. We, therefore, predicted that this network would be reorganized via musical training-induced neuroplasticity. To test this hypothesis, we analyzed resting-state functional connectivity of the thalamocortical network in musicians (n = 35) and nonmusicians (n = 35)...
April 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28377158/task-difficulty-modulates-brain-activation-in-the-emotional-oddball-task
#17
Rachel E Siciliano, David J Madden, Catherine W Tallman, Maria A Boylan, Imke Kirste, Zachary A Monge, Lauren E Packard, Guy G Potter, Lihong Wang
Previous functional magnetic resonance imaging (fMRI) studies have reported that task-irrelevant, emotionally salient events can disrupt target discrimination, particularly when attentional demands are low, while others demonstrate alterations in the distracting effects of emotion in behavior and neural activation in the context of attention-demanding tasks. We used fMRI, in conjunction with an emotional oddball task, at different levels of target discrimination difficulty, to investigate the effects of emotional distractors on the detection of subsequent targets...
April 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28377157/age-effects-on-associative-memory-for-novel-picture-pairings
#18
Emma K Bridger, Anna-Lena Kursawe, Regine Bader, Roni Tibon, Nurit Gronau, Daniel A Levy, Axel Mecklinger
Normal aging is usually accompanied by greater memory decline for associations than for single items. Though associative memory is generally supported by recollection, it has been suggested that familiarity can also contribute to associative memory when stimuli can be unitized and encoded as a single entity. Given that familiarity remains intact during healthy aging, this may be one route to reducing age-related associative deficits. The current study investigated age-related differences in associative memory under conditions that were expected to differentially promote unitization, in this case by manipulating the spatial arrangement of two semantically unrelated objects positioned relative to each other in either spatially implausible or plausible orientations...
April 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28372943/neural-signatures-of-language-co-activation-and-control-in-bilingual-spoken-word-comprehension
#19
Peiyao Chen, Susan C Bobb, Noriko Hoshino, Viorica Marian
To examine the neural signatures of language co-activation and control during bilingual spoken word comprehension, Korean-English bilinguals and English monolinguals were asked to make overt or covert semantic relatedness judgments on auditorily-presented English word pairs. In two critical conditions, participants heard word pairs consisting of an English-Korean interlingual homophone (e.g., the sound /mu:n/ means "moon" in English and "door" in Korean) as the prime and an English word as the target. In the homophone-related condition, the target (e...
March 31, 2017: Brain Research
https://www.readbyqxmd.com/read/28366617/acute-dosing-of-vortioxetine-strengthens-event-related-brain-activity-associated-with-engagement-of-attention-and-cognitive-functioning-in-rats
#20
Bettina Laursen, Cecilie H Bundgaard, Carina Graversen, Morten Grupe, Connie Sanchez, Steven C Leiser, Helge B D Sorensen, Asbjørn M Drewes, Jesper F Bastlund
Studies of the antidepressant vortioxetine have demonstrated beneficial effects on cognitive dysfunction associated with depression. To elucidate how vortioxetine modulates neuronal activity during cognitive processing we investigated the effects of vortioxetine (3 and 10 mg/kg) in rats performing an auditory oddball (deviant target) task. We investigated neuronal activity in target vs non-target tone responses in vehicle-treated animals using electroencephalographic (EEG) recordings. Furthermore, we characterized task performance and EEG changes in target tone responses of vortioxetine vs controls...
March 30, 2017: Brain Research
journal
journal
21333
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"