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Japanese Journal of Ophthalmology

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https://www.readbyqxmd.com/read/29785639/development-of-a-molecular-diagnostic-test-for-retinitis-pigmentosa-in-the-japanese-population
#1
Akiko Maeda, Akiko Yoshida, Kanako Kawai, Yuki Arai, Ryutaro Akiba, Akira Inaba, Seiji Takagi, Ryoji Fujiki, Yasuhiko Hirami, Yasuo Kurimoto, Osamu Ohara, Masayo Takahashi
PURPOSE: Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy caused by different genetic variants. More than 60 causative genes have been identified to date. The establishment of cost-effective molecular diagnostic tests with high sensitivity and specificity can be beneficial for patients and clinicians. Here, we developed a clinical diagnostic test for RP in the Japanese population. STUDY DESIGN: Evaluation of diagnostic technology, Prospective, Clinical and experimental study...
May 21, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29766356/endothelial-cell-loss-and-graft-survival-after-penetrating-keratoplasty-for-laser-iridotomy-induced-bullous-keratopathy
#2
Naoki Okumura, Ayaka Kusakabe, Noriko Koizumi, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Kazuhiko Mori, Chie Sotozono, Shigeru Kinoshita
PURPOSE: To assess corneal endothelial cell loss after penetrating keratoplasty (PK) treatment for laser iridotomy (LI)-induced bullous keratopathy (BK). METHODS: A retrospective study conducted on consecutive patients who underwent PK between March 2000 and December 2011. Patients who had undergone more than 24 months of follow-up were included. Patients who underwent PK were subcategorized into two groups based on their diagnosis of BK prior to PK; PK was performed to treat either LI-BK or non LI-BK...
May 15, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29748866/two-cases-of-repeating-recurrences-and-spontaneous-closures-of-macular-holes-in-vitrectomized-eyes
#3
Takamasa Mori, Seiji Kitamura, Hirokazu Sakaguchi, Kohji Nishida, Masahito Ohji
BACKGROUND: Three eyes of 2 cases had repeating recurrences and spontaneous closures of macular holes (MHs) after vitrectomy. CASES: A 66-year-old man had rhegmatogenous retinal detachment (RRD) in his left eye and underwent vitrectomy with successful retinal reattachment. A full-thickness MH developed 1 year after the vitrectomy and spontaneously closed 1 month later. Opening and spontaneous closure of the MH recurred an additional 4 times over 7 years. An 80-year-old man had suffered intraocular lens (IOL) dislocation and underwent vitrectomy in his left eye...
May 10, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29713904/gene-expression-changes-in-the-retina-after-systemic-administration-of-aldosterone
#4
Aoi Ono, Kazuyuki Hirooka, Yuki Nakano, Eri Nitta, Akira Nishiyama, Akitaka Tsujikawa
PURPOSE: Retinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs after the systemic administration of aldosterone. Since it is important to determine the mechanism of cell death independent of the IOP, we examined gene expression changes in the retina after the systemic administration of aldosterone. METHODS: Following subcutaneous implantation of an osmotic minipump into the mid-scapular region of rats, we administered an 80 μg/kg/day dose of aldosterone...
April 30, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29700642/evaluation-of-corneal-biomechanics-in-patients-with-keratectasia-following-lasik-using-dynamic-scheimpflug-analyzer
#5
Ryotaro Ueki, Naoyuki Maeda, Mutsumi Fuchihata, Tomoko Asai, Shizuka Koh, Hisataka Fujimoto, Masafumi Uematsu, Kohji Nishida
PURPOSE: To investigate the corneal biomechanics in eyes with keratectasia following LASIK using a dynamic Scheimpflug analyzer. DESIGN: Case-Control study. METHOD: The subjects in the study included 12 eyes with keratectasia after LASIK (KE), 24 eyes with keratoconus (KC), 17 eyes without keratectasia after LASIK (LASIK), and 34 eyes with normal corneas (Normal). Corneal biomechanics of the four groups were evaluated using a dynamic Scheimpflug analyzer...
April 26, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29696464/comparison-of-changes-of-macular-ganglion-cell-inner-plexiform-layer-defect-between-stable-group-and-progression-group-in-primary-open-angle-glaucoma
#6
Bo Ram Seol, Byeong Wook Yoo, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To compare the changes in macular ganglion cell-inner plexiform layer (GCIPL) defect between stable and progression primary open-angle glaucoma (POAG) groups. STUDY DESIGN: Retrospective observational study. METHODS: A total of 100 POAG eyes with localized retinal nerve fiber layer (RNFL) defect and corresponding macular GCIPL defect were selected for this study. Glaucoma progression was defined by either structural or functional deterioration...
April 25, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29691783/optimization-of-fixative-solution-for-retinal-morphology-a-comparison-with-davidson-s-fixative-and-other-fixation-solutions
#7
Kazuhiro Tokuda, Byron Baron, Yasuhiro Kuramitsu, Takao Kitagawa, Nobuko Tokuda, Naoyuki Morishige, Masaaki Kobayashi, Kazuhiro Kimura, Kazuyuki Nakamura, Koh-Hei Sonoda
PURPOSE: Numerous fixative solutions are available but many are not amenable to the histomorphological preservation of retinae. The investigators specifically focused on retinal histological studies, which rather than 4% formaldehyde (FA), often use Davidson's fixative. However the latter has its limitations. The purpose of this study was to produce a new fixative which maintains retinae closer to the in vivo conditions. STUDY DESIGN: Experimental design. METHODS: Four fixative formulations (4% paraformaldehyde, Davidson's fixative, modified Davidson's fixative and an in-house fixative - TB-Fix) were tested on retinae and the outcomes on histomorphology and immunohistochemical staining for selected antigenic markers was compared...
April 24, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29666954/clinical-characteristics-of-a-japanese-patient-with-bardet-biedl-syndrome-caused-by-bbs10-mutations
#8
Kentaro Kurata, Katsuhiro Hosono, Akiko Hikoya, Akihiko Kato, Hirotomo Saitsu, Shinsei Minoshima, Tsutomu Ogata, Yoshihiro Hotta
PURPOSE: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder characterized by retinal dystrophy, renal dysfunction, central obesity, mental impairment, polydactyly, and hypogonadism. Only limited information on BBS is available from Japanese patients. In addition, there are currently no reports of Japanese patients with BBS caused by BBS10 mutations. The purpose of this study was to present the characteristics of a Japanese patient with BBS caused by BBS10 mutations. PATIENT AND METHODS: The patient was a 22-year-old Japanese woman...
April 17, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29594610/extended-field-imaging-using-swept-source-optical-coherence-tomography-angiography-in-retinal-vein-occlusion
#9
Shinji Kakihara, Takao Hirano, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Toshinori Murata
PURPOSE: To evaluate the degree of ischemia in eyes with retinal vein occlusion (RVO) using swept-source optical coherence tomography angiography (SS-OCTA) with the extended field imaging (EFI) technique, which extends the area encompassed by SS-OCTA by scanning through trial frames fitted with a +20-diopter lens. STUDY DESIGN: Retrospective observational study. METHODS: Twenty-three consecutive eyes of 22 patients with RVO underwent 12 × 12 mm SS-OCTA imaging both with and without EFI for determination of extension rate...
March 28, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29594609/reliability-of-a-commercially-available-heterochromatic-flicker-photometer-the-mps2-for-measuring-the-macular-pigment-optical-density-of-a-japanese-population
#10
Akira Obana, Yuko Gohto, Takatoshi Moriyama, Takahiko Seto, Hiroyuki Sasano, Shigetoshi Okazaki
PURPOSE: The macular pigment optical density (MPOD) of a Japanese population was measured using a commercially based heterochromatic flicker photometer, the Macular Pigment Screener (MPS2). The objective of the study was to evaluate the accuracy and test-retest reliability of the MPS2 in Asian pigmented eyes. STUDY DESIGN: Experimental study to validate the medical instrument in humans. METHODS: Twenty-four healthy Japanese participants with no systemic or eye diseases (men: 13, women: 11; mean [SD] age 38...
March 28, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29582190/evaluation-of-efficacy-of-infliximab-for-retinal-vasculitis-and-extraocular-symptoms-in-beh%C3%A3-et-disease
#11
Akihiko Umazume, Takeshi Kezuka, Yoshihiko Usui, Jun Suzuki, Hiroshi Goto
PURPOSE: We evaluated ocular symptoms and activity of retinal vasculitis of Behçet disease before and after infliximab therapy, using Behçet disease ocular attack score 24 (BOS24) and fluorescein angiography (FA) score. We also analyzed the efficacy of infliximab for ocular and extraocular symptoms. STUDY DESIGN: Retrospective study. SUBJECT AND METHODS: Using medical records, we analyzed FA and BOS24 to evaluate the association between the efficacy of infliximab therapy and FA as well as BOS24 scores...
March 26, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29572578/crucial-role-of-p2x-7-receptor-for-effector-t-cell-activation-in-experimental-autoimmune-uveitis
#12
Atsunobu Takeda, Hisakata Yamada, Eiichi Hasegawa, Mitsuru Arima, Shoji Notomi, Sayaka Myojin, Takeru Yoshimura, Toshio Hisatomi, Hiroshi Enaida, Ryoji Yanai, Kazuhiro Kimura, Tatsuro Ishibashi, Koh-Hei Sonoda
PURPOSE: To investigate the roles of P2X7 receptors (P2RX7) in the pathogenesis of experimental autoimmune uveoretinitis (EAU). STUDY DESIGN: Experimental. METHODS: Either wild-type (P2rx7+/+ ) or P2rx7-deficient (P2rx7-∕- ) mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) peptide 1-20. Severity of EAU was evaluated clinically and histopathologically. The induction of IRBP-specific proliferation and cytokines in draining lymph nodes was assessed by enzyme-linked immunosorbent assays (ELISA)...
March 23, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29623543/comparison-of-visual-acuity-metamorphopsia-and-aniseikonia-in-patients-with-an-idiopathic-epiretinal-membrane
#13
Atsuhiro Tanikawa, Yoshiaki Shimada, Masayuki Horiguchi
PURPOSE: The clinical course of reduced visual acuity, metamorphopsia, and aniseikonia are dissimilar in patients with an epiretinal membrane (ERM). We measured and compared the best-corrected visual acuity (BCVA), metamorphopsia, and aniseikonia of patients with ERM. METHODS: We measured metamorphopsia and aniseikonia horizontally as well as vertically with the M-CHART (MH and MV) and New Aniseikonia Test (NATH and NATV) in 61 patients with unilateral idiopathic ERM...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29572577/mechanisms-of-vision-loss-in-eyes-with-macular-edema-associated-with-retinal-vein-occlusion
#14
REVIEW
Hiroyuki Iijima
Anti-vascular endothelial growth factor agents reduce macular edema and improve vision in eyes with macular edema associated with retinal vein occlusion (RVO), including branch RVO (BRVO) and central RVO. However, not all eyes with resolved macular edema show satisfactory best corrected visual acuity. Photoreceptor impairment can mostly explain the vision loss in these cases. Photoreceptor damage can be caused by subretinal hemorrhage in the central fovea and hard exudates or their precursor derived from concentrated lipoproteins originating from leaky retinal vessel extravasation...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29556848/role-of-fusional-convergence-amplitude-in-postoperative-phoria-maintenance-in-children-with-intermittent-exotropia
#15
Akemi Wakayama, Yukari Seki, Rika Takahashi, Ikumi Umebara, Fumi Tanabe, Kosuke Abe, Fumiko Matsumoto, Yoshikazu Shimomura
PURPOSE: To examine the role of fusional convergence amplitude in postoperative phoria maintenance in childhood intermittent exotropia [X(T)]. METHODS: The medical records of 29 children aged 15 years or younger (mean age, 10.8 ± 2.4 years) and treated with monocular recession-resection for X(T) were reviewed retrospectively. The patients' fusional convergence amplitude (break point/total amplitudes), physiologic diplopia, and phoria maintenance (presence/absence of phoria maintenance and ability to maintain phoria) were assessed...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29549462/risk-factors-for-pterygium-recurrence-after-limbal-conjunctival-autografting-a-retrospective-single-centre-investigation
#16
Naser Samadi Aidenloo, Qader Motarjemizadeh, Maryam Heidarpanah
PURPOSE: To determine the risk factors related to recurrence of pterygium after pterygium excision with limbal-conjunctival autograft. STUDY DESIGN: Retrospective, observational case series. METHODS: The current study included 310 patients who underwent surgical removal of pterygium using limbal-conjunctival autografting. All surgery was performed by the same surgeon at a single Hospital from 2006 to 2011. Preoperative and postoperative patient data were collected...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29549461/assessment-of-corneal-backward-light-scattering-in-the-healthy-cornea-and-factors-affecting-corneal-transparency
#17
Ali Bulent Cankaya, Kemal Tekin, Hasan Kiziltoprak, Sevilay Karahan, Pelin Yilmazbas
PURPOSE: To quantify normative corneal optical density (COD) values of healthy individuals and to investigate alterations in the COD in relation to their ocular and demographic characteristics. STUDY DESIGN: Prospective, cross-sectional, and observational. METHODS: In total, 588 eyes from 588 healthy participants with clear corneas were consecutively enrolled. Corneal densitometry values expressed in standardized grayscale units (GSU) from different corneal layers and zones obtained using the rotating Pentacam Scheimpflug system were analyzed...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29532273/detection-of-increase-in-corneal-irregularity-due-to-pterygium-using-fourier-series-harmonic-analyses-with-multiple-diameters
#18
Keiichiro Minami, Kazunori Miyata, Atsushi Otani, Tadatoshi Tokunaga, Shouta Tokuda, Shiro Amano
PURPOSE: To determine steep increase of corneal irregularity induced by advancement of pterygium. METHODS: A total of 456 eyes from 456 consecutive patients with primary pterygia were examined for corneal topography and advancement of pterygium with respect to the corneal diameter. Corneal irregularity induced by the pterygium advancement was evaluated by Fourier harmonic analyses of the topographic data that were modified for a series of analysis diameters from 1 mm to 6 mm...
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29532272/publisher-correction-to-effect-of-glaucoma-implant-surgery-on-intraocular-pressure-reduction-flare-count-anterior-chamber-depth-and-corneal-endothelium-in-primary-open-angle-glaucoma
#19
Kyoko Ishida, Naoya Moroto, Kazuhiro Murata, Tetsuya Yamamoto
The publisher regrets that the original version.
May 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29524061/the-effect-of-orthokeratology-on-axial-length-elongation-in-children-with-myopia-contralateral-comparison-study
#20
Miri Na, Aeri Yoo
PURPOSE: To evaluate the effectiveness of the orthokeratology (OK) lens slowing myopic progression compared with no intervention in pediatric eyes METHODS: A retrospective review of medical records was performed on 45 monocular myopic subjects 7 to 13 years of age who were treated with monocular ortho-k lens and followed-up for more than 12 months. The monocular myopia in the subjects' eyes was -0.75 to -4.25 D (diopter), and near emmetropia in the contralateral and with-the-rule astigmatism no greater than -1...
May 2018: Japanese Journal of Ophthalmology
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