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Japanese Journal of Ophthalmology

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https://www.readbyqxmd.com/read/27928695/one-year-outcomes-of-a-treat-and-extend-regimen-of-intravitreal-aflibercept-for-polypoidal-choroidal-vasculopathy
#1
Mio Hosokawa, Yuki Morizane, Masayuki Hirano, Shuhei Kimura, Fumiaki Kumase, Yusuke Shiode, Shinichiro Doi, Shinji Toshima, Mika Hosogi, Atsushi Fujiwara, Toshiharu Mitsuhashi, Fumio Shiraga
PURPOSE: To evaluate the 1-year treatment outcomes of intravitreal aflibercept injections (IVA) using a treat-and-extend regimen for polypoidal choroidal vasculopathy (PCV). METHODS: Thirty-seven eyes with treatment-naive PCV treated with IVA using a treat-and-extend regimen for 1 year were reviewed retrospectively. The main outcome measures were changes in the best-corrected visual acuity (BCVA) and central retinal thickness (CRT), and the treatment interval at 1 year...
December 7, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27888376/laser-flare-cell-photometer-principle-and-significance-in-clinical-and-basic-ophthalmology
#2
REVIEW
Mitsuru Sawa
A slit-lamp examination is an indispensable and essential clinical evaluation method in ophthalmology, but, it is qualitative subjective. To complement its weaknesses in making a quantitative evaluation of flare intensity and number of cells in the aqueous humor in the eye, we invented the laser flare-cell photometer in 1988. The instrument enables a non-invasive quantitative evaluation of flare intensity and number of cells in the aqueous with good accuracy and repeatability as well as maneuverability equal to slit-lamp microscopy...
November 25, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27885526/twelve-year-follow-up-of-penetrating-keratoplasty
#3
Takashi Ono, Sosuke Ishiyama, Takeshi Hayashidera, Yosai Mori, Ryohei Nejima, Kazunori Miyata, Shiro Amano
PURPOSE: To evaluate the long-term outcomes of penetrating keratoplasty (PKP) according to the corneal disease diagnosis and the number of PKP procedures performed. METHODS: Five-hundred-and-nine eyes from 403 patients who underwent PKP at Miyata Eye Hospital in Japan from 1998 through 2014, were included in this study. Medical charts were retrospectively examined to ascertain the corneal disease diagnosis and the period of graft survival. Graft survival rates were compared among various corneal disease diagnoses and among the number of PKP procedures performed...
November 24, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27848108/the-effect-of-the-extent-of-the-incision-in-the-schlemm-canal-on-the-surgical-outcomes-of-suture-trabeculotomy-for-open-angle-glaucoma
#4
Shin-Ichi Manabe, Shoichi Sawaguchi, Ken Hayashi
PURPOSE: To examine the relationship between the extent of the incision in the Schlemm canal during suture trabeculotomy (S-LOT) for open-angle glaucoma and the associated reduction in intraocular pressure (IOP). METHODS: Forty-eight consecutive eyes (primary open-angle glaucoma: 28; exfoliation glaucoma: 20) scheduled to undergo S-LOT were studied. A 320-degree opening in the Schlemm canal was planned when total circumferential cannulation had been achieved, and the remaining 40-degree region under the scleral flap was not incised...
November 15, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27787641/a-new-era-of-uveitis-impact-of-polymerase-chain-reaction-in-intraocular-inflammatory-diseases
#5
REVIEW
Manabu Mochizuki, Sunao Sugita, Koju Kamoi, Hiroshi Takase
Uveitis is a sight-threatening intraocular inflammatory disorder which may occur from both infectious and non-infectious or autoimmune causes. The frequency of infectious uveitis and autoimmune uveitis varies depending on countries and regions. According to a nationwide survey conducted by the Japanese Ocular Inflammation Society, infectious and non-infectious uveitis accounted for 16.4 and 50.1% of new patients, respectively while the remaining 33.5% of new uveitis cases were not classified or were idiopathic uveitis...
October 27, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27730425/effect-of-leaking-perifoveal-microaneurysms-on-resolution-of-diabetic-macular-edema-treated-by-combination-therapy-using-anti-vascular-endothelial-growth-factor-and-short-pulse-focal-grid-laser-photocoagulation
#6
Takao Hirano, Yuichi Toriyama, Yasuhiro Iesato, Akira Imai, Kazutaka Hirabayashi, Taiji Nagaoka, Yoshihiro Takamura, Masahiko Sugimoto, Toshinori Murata
PURPOSE: The effect of combination therapy using intravitreal ranibizumab (IVR) injections and short pulse focal/grid laser photocoagulation was evaluated for the treatment of diabetic macular edema (DME). METHODS: The current investigation was a preliminary single-arm, open-label, prospective clinical study conducted on 21 eyes at 4 sites in Japan. Treatment protocol consisted of two phases. The induction IVR phase included two monthly IVRs followed by PRN IVR phase in which additional IVR was administered if the central macular thickness (CMT) exceeded 300 μm...
October 11, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27722786/clinical-practice-pattern-in-management-of-diabetic-macular-edema-in-japan-survey-results-of-japanese-retinal-specialists
#7
Yuichiro Ogura, Fumio Shiraga, Hiroko Terasaki, Masahito Ohji, Susumu Ishida, Taiji Sakamoto, Akito Hirakata, Tatsuro Ishibashi
PURPOSE: To elucidate the current clinical practice patterns of diabetic macular edema (DME) management by retinal specialists in Japan in the era of anti-vascular endothelial growth factor (VEGF) therapy. METHODS: Forty-six retinal specialists were administered a survey regarding the pathology and clinical practice of DME. RESULTS: Nearly, half of the specialists (45.2 %) think that the main biochemical factor involved in DME development is the vascular permeability-potentiating action of VEGF-A...
October 8, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27718026/effect-of-vitreomacular-separation-on-macular-thickness-determined-by-spectral-domain-optical-coherence-tomography
#8
Kazuyuki Kumagai, Akinori Uemura, Masanori Hangai, Tetsuyuki Suetsugu, Nobuchika Ogino
PURPOSE: To determine the effects of vitreomacular separation on macular thickness. METHODS: This was a retrospective, observational, cross-sectional study. Average foveal and central minimum thicknesses were measured by spectral-domain optical coherence tomography (SD-OCT) in 308 eyes of 308 healthy subjects (healthy group) and 298 normal fellow eyes of 298 patients with a unilateral macular hole (MH group). Multiple regression analyses were performed to determine the effects of various factors on the macular thickness...
October 7, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27718025/in-vivo-imaging-of-a-cone-mosaic-in-a-patient-with-achromatopsia-associated-with-a-gnat2-variant
#9
Shinji Ueno, Ayami Nakanishi, Taro Kominami, Yasuki Ito, Takaaki Hayashi, Kazutoshi Yoshitake, Yuichi Kawamura, Kazushige Tsunoda, Takeshi Iwata, Hiroko Terasaki
PURPOSE: The 2 most common causative genes for achromatopsia (ACHM) are CNGA3 and CNGB3; other genes including GNAT2 account for only a small portion of ACHM cases. The cone mosaics in eyes with CNGA3 and CNGB3 variants are severely disrupted; the cone mosaics in patients with GNAT2-associated ACHM; however, have been reported to show a contiguous pattern in adaptive optics (AO) retinal images. The purpose of this study was to analyze the cone mosaic of another case of GNAT2-associated ACHM...
October 7, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27714572/wound-stability-and-surgically-induced-corneal-astigmatism-after-transconjunctival-single-plane-sclerocorneal-incision-cataract-surgery
#10
Ken Hayashi, Soichiro Ogawa, Motoaki Yoshida, Koichi Yoshimura
PURPOSE: To compare intraocular pressure (IOP) immediately after cataract surgery, and surgically induced corneal astigmatism (SIA) and corneal shape changes between eyes with transconjunctival single-plane sclerocorneal incisions (TSSIs) and eyes with clear corneal incisions (CCIs). METHODS: Bilateral eyes of 64 patients undergoing phacoemulsification were randomized to undergo 2.4-mm temporal TSSI or CCI. IOP was measured preoperatively, and in the immediate postoperative periods...
October 6, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27709394/subfoveal-choroidal-thickness-in-polypoidal-choroidal-vasculopathy-after-switching-to-intravitreal-aflibercept-injection
#11
(no author information available yet)
No abstract text is available yet for this article.
October 5, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27699522/eyelid-cleansing-with-ointment-for-obstructive-meibomian-gland-dysfunction
#12
Minako Kaido, Osama M A Ibrahim, Motoko Kawashima, Reiko Ishida, Enrique A Sato, Kazuo Tsubota
PURPOSE: To investigate the efficacy of eyelid margin cleansing with ofloxacin ophthalmic ointment in obstructive meibomian gland dysfunction (MGD) patients. METHODS: Thirty-one eyes of 31 patients diagnosed with obstructive MGD were enrolled. All subjects were instructed to rub the eyelid edge with ofloxacin eye ointment once daily prior to bathing. Lid margin abnormalities, meibum properties, and tear stability were observed before and 3 months after ointment treatment...
October 3, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27699521/longitudinal-change-in-choroidal-thickness-after-trabeculectomy-in-primary-open-angle-glaucoma-patients
#13
Munemitsu Yoshikawa, Tadamichi Akagi, Hideo Nakanishi, Hanako Ohashi Ikeda, Satoshi Morooka, Hiroshi Yamada, Tomoko Hasegawa, Yuto Iida, Nagahisa Yoshimura
PURPOSE: To investigate longitudinal changes in intraocular pressure (IOP), axial length (AL), and choroidal thickness (ChT) in primary open-angle glaucoma (POAG) eyes after trabeculectomy and to evaluate the parameters that might influence those changes. METHODS: In this prospective observational study, we recruited 28 patients with POAG (28 eyes) scheduled for trabeculectomy. The average macular ChTs and foveal retinal thicknesses along 6-mm segments centered on the fovea were examined preoperatively and postoperatively (at 1, 3, and 6 months) using swept-source optical coherence tomography...
October 3, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27663239/retreatment-of-polypoidal-choroidal-vasculopathy-after-photodynamic-therapy-combined-with-intravitreal-ranibizumab
#14
Wataru Kikushima, Yoichi Sakurada, Atsushi Sugiyama, Naohiko Tanabe, Seigo Yoneyama, Hiroyuki Iijima
PURPOSE: To investigate the incidence, risk factors and effect on visual improvement of retreatment within 60 months after initial photodynamic therapy (PDT) combined with intravitreal ranibizumab (IVR) in eyes with treatment-naïve polypoidal choroidal vasculopathy (PCV). METHODS: We retrospectively reviewed the medical records of 61 eyes from 60 patients with PCV, who were followed up for at least 12 months after undergoing combination therapy. Retreatment, including combination therapy or IVR alone, was administered if residual or recurrent exudative changes were present...
September 23, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27660164/efficacy-of-intravitreal-aflibercept-in-japanese-patients-with-exudative-age-related-macular-degeneration
#15
Masaaki Saito, Mariko Kano, Kanako Itagaki, Tetsuju Sekiryu
PURPOSE: To clarify the efficacy of aflibercept for treating exudative age-related macular degeneration (AMD). METHODS: We prospectively studied 47 eyes with AMD. Forty-seven patients (mean age 72.2 years) received three consecutive monthly intravitreal aflibercept injections followed by an injection every 2 months until 12 months. The primary outcome was the 12-month visual results compared with baseline; the secondary outcomes were the prevalence of geography atrophy (GA), a dry macula at month 12, and anatomic changes on optical coherence tomography...
September 22, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27660163/comparison-between-ranibizumab-and-aflibercept-for-macular-edema-associated-with-central-retinal-vein-occlusion
#16
Yoshitsugu Saishin, Yuka Ito, Masato Fujikawa, Tomoko Sawada, Masahito Ohji
PURPOSE: We compared the efficacy of bimonthly intravitreal injections of ranibizumab (IVR) with that of bimonthly intravitreal injections of aflibercept (IVA) in two prospective, consecutive groups of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO). PATIENTS AND METHODS: Eyes with ME after CRVO received either bimonthly IVR (ranibizumab group; n = 13) or IVA (aflibercept group; n = 13) injections and were followed monthly for 6 months...
September 22, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27770271/scientific-reviewers
#17
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27585920/in-vivo-confocal-microscopic-observations-of-eyes-diagnosed-with-posterior-corneal-vesicles
#18
Atsushi Shiraishi, Xiaodong Zheng, Yuri Sakane, Yuko Hara, Yasuhito Hayashi
PURPOSE: To determine the morphological characteristics of the cornea in eyes with posterior corneal vesicles (PCV) determined by in vivo confocal microscopy (IVCM). In addition, to compare the morphological characteristics of the corneas of eyes with PCV to those of eyes with posterior polymorphous corneal dystrophy (PPCD). METHODS: Three males and three females aged 17-75 years who were diagnosed with PCV by slit-lamp biomicroscopic findings were studied. The slit-lamp findings, specular microscopic images, corneal endothelial cell densities (CDs), central corneal thickness, and IVCM images were evaluated...
September 1, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27401170/national-survey-of-pellucid-marginal-corneal-degeneration-in-japan
#19
Jun Shimazaki, Naoyuki Maeda, Osamu Hieda, Yuichi Ohashi, Akira Murakami, Kohji Nishida, Kazuo Tsubota
PURPOSE: A national survey was conducted in Japan to analyze the clinical characteristics of pellucid marginal corneal degeneration (PMD). METHODS: A questionnaire was sent to all members of the Japan Cornea Society requesting demographic and clinical findings on PMD patients who had been examined between 2008 and 2010. The presence of band-shaped peripheral corneal thinning, detected by slit-lamp biomicroscopy or by a pachymetric map, was set as the diagnostic criterion of PMD...
September 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27379999/the-role-of-prdx6-in-the-protection-of-cells-of-the-crystalline-lens-from-oxidative-stress-induced-by-uv-exposure
#20
Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Hiroshi Sasaki, Dhirendra P Singh, Eri Kubo
PURPOSE: The immediate aim of this study was to investigate alterations in peroxiredoxin (Prdx) 6 at posttranslational levels, and the levels of protein oxidation, lipid peroxidation, and reactive oxygen species (ROS) in lens epithelial cells (LECs) after exposure to severe oxidative stress, such as ultraviolet-B (UV-B). Our ultimate aim was to provide new information on antioxidant defenses in the lens and their regulation, thereby broadening existing knowledge of the role of Prdx6 in lens physiology and pathophysiology...
September 2016: Japanese Journal of Ophthalmology
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