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Japanese Journal of Ophthalmology

Suresh Subramaniam, Jin Wook Jeoung, Won June Lee, Young Kook Kim, Ki Ho Park
PURPOSE: To compare the diagnostic capability of three-dimensional (3D) neuro-retinal rim thickness (NRR) with existing optic nerve head and retinal nerve fiber layer (RNFL) scan parameters using high-definition optical coherence tomography (HD-OCT). DESIGN: Retrospective study. METHODS: Based on the mean deviation (MD) of the Humphrey Field Analyzer (HFA), the 152 subjects were categorized into mild (MD > - 6 dB, 100), moderate (MD - 6 to - 12 dB, 26), and severe (MD < - 12 dB, 26) glaucoma...
September 18, 2018: Japanese Journal of Ophthalmology
Daisuke Shimizu, Dai Miyazaki, Yumiko Shimizu, Mayumi Hosogai, Isao Kosugi, Yoshitsugu Inoue
PURPOSE: Human cytomegalovirus (HCMV) infections can cause endotheliitis which is associated with an elevation in the intraocular pressure (IOP). However, the mechanism of the IOP elevation has not been established. The purpose of this study was to determine whether HCMV strains which are capable of infecting corneal endothelial cells can also replicate and induce anti-viral responses, and can reorganize the actin cytoskeleton in trabecular meshwork cells. STUDY DESIGN: Experimental study design...
September 6, 2018: Japanese Journal of Ophthalmology
Manami Kawai, Toshiaki Goseki, Hitoshi Ishikawa, Miki Hoshina, Nobuyuki Shoji
PURPOSE: We evaluated the background and characteristics of elderly patients with binocular diplopia including diseases caused by abnormalities in orbital pulleys. STUDY DESIGN: Retrospective. METHODS: The participants were 236 patients aged 60 years or older who visited Kitasato University Hospital complaining of binocular diplopia. We classified strabismus by types and investigated the causes for each group. We diagnosed orbital pulley disorders using magnetic resonance imaging (MRI)...
August 12, 2018: Japanese Journal of Ophthalmology
Seiji Takagi, Michiko Mandai, Yasuhiko Hirami, Sunao Sugita, Masayo Takahashi, Yasuo Kurimoto
PURPOSE: Stem cell therapy is a potential treatment for retinal disorders. We are currently exploring treating HLA matched patients of age-related macular degeneration (AMD) by using allogenic retinal pigment epithelium cells derived from induced pluripotent stem cells (iPS-RPE) from human leukocyte antigen (HLA) homozygote donors. The purpose of this study was to investigate the frequency of HLA class I and II alleles and haplotypes in Japanese patients with AMD. STUDY DESIGN: Cross-sectional observation clinical study...
July 12, 2018: Japanese Journal of Ophthalmology
Nattapong Mekhasingharak, Niphon Chirapapaisan, Poramaet Laowanapiban, Sasitorn Siritho, Naraporn Prayoonwiwat, Chanjira Satukijchai, Jiraporn Jitprapaikulsan, Pornsawan Mekhasingharak
PURPOSE: To investigate the correlation between visual function and thinning of the retinal nerve fiber layer (RNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) as measured by optical coherence tomography (OCT) in eyes with aquaporin-4 IgG-positive optic neuritis (AQP4-IgG-positive ON). STUDY DESIGN: Prospective study. METHODS: Patients with a history of ON were categorized into 2 groups: the AQP4-IgG-positive group and the AQP4-IgG-negative group...
July 11, 2018: Japanese Journal of Ophthalmology
Naoko Kato, Kenji Konomi, Megumi Shinzawa, Kozue Kasai, Takeshi Ide, Ikuko Toda, Chikako Sakai, Kazuno Negishi, Kazuo Tsubota, Jun Shimazaki
PURPOSE: We retrospectively investigated the efficacy of corneal crosslinking (CXL) on progressive keratoconus in a Japanese population and compared the outcomes of conventional and accelerated CXL. STUDY DESIGN: A retrospective cohort study METHODS: A total of 108 consecutive eyes in 95 patients (75 men; 21.9 ± 6.2 years) with progressive keratoconus were enrolled. The epithelium was ablated in all eyes. After presoaking the corneal stroma in riboflavin, UV-A was irradiated at 3...
July 10, 2018: Japanese Journal of Ophthalmology
Hiroyuki Kanda, Tetsuro Oshika, Takahiro Hiraoka, Satoshi Hasebe, Kyoko Ohno-Matsui, Satoshi Ishiko, Osamu Hieda, Hidemasa Torii, Saulius R Varnas, Takashi Fujikado
PURPOSE: Novel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children. STUDY DESIGN: This was a multicenter prospective randomized double-blind placebo-controlled trial. METHOD: We enrolled 207 participants (aged 6-12 years) with spherical equivalent refractions (SERs) ranging from -1...
September 2018: Japanese Journal of Ophthalmology
Yasuharu Oguchi, Tetsuju Sekiryu, Mika Takasumi, Yuko Hashimoto, Minoru Furuta
PURPOSE: To determine histopathologic characteristics of near-infrared autofluorescence (NIR-AF) and short-wave autofluorescence (SW-AF) in ocular tissue. STUDY DESIGN: Retrospective study. METHODS: Unstained specimens from four enucleated eyes with uveal melanoma were prepared for evaluation by fluorescence microscopy. The filter settings for SW-AF were 450-490 nm for excitation, 500-550 nm for emission and for NIR-AF 672.5-747.5 nm and 765-855 nm respectively...
September 2018: Japanese Journal of Ophthalmology
Yohei Takahashi, Hideki Koizumi, Taiji Hasegawa, Takahiko Izumi, Ichiro Maruko, Shozo Sonoda, Taiji Sakamoto, Tomohiro Iida
PURPOSE: To evaluate and compare the intrachoroidal structures of eyes with typical neovascular age-related macular degeneration (AMD) with those of eyes with polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective and comparative case series. METHODS: Eighty-four treatment-naïve eyes of 84 patients (22 women and 62 men) with typical neovascular AMD or PCV located in the subfoveal region were studied. Cross-sectional images of the retina and choroid were obtained by swept-source optical coherence tomography (SS-OCT)...
September 2018: Japanese Journal of Ophthalmology
Akemi Wakayama, Sachiko Nishina, Atsushi Miki, Takashi Utsumi, Jun Sugasawa, Takao Hayashi, Miho Sato, Akiko Kimura, Takashi Fujikado
PURPOSE: To investigate the incidence rate and side effects of topical atropine sulfate and cyclopentolate hydrochloride for cycloplegia in children aged 15 years or under. METHODS: This prospective study had been conducted at 9 institutions between April 1, 2016 and March 31, 2017 in patients 15 years old or younger who received either atropine or cyclopentolate for refraction assessment. The investigation included patient's age, symptoms, and whether patients with side effects had any systemic diseases...
September 2018: Japanese Journal of Ophthalmology
Yoshifumi Okamoto, Fumiki Okamoto, Tetsuro Oshika
PURPOSE: A surgical technique is described that facilitates membrane peeling in patients with macular diseases by using small amounts of perfluorocarbon liquid (PFCL) and brilliant blue G (BBG) dye. STUDY DESIGN: Retrospective cohort study. METHODS: After placing about 1.0-1.5 cc PFCL on the macular area, BBG was applied with a 27-gauge blunt needle at the interface of PFCL and retina. The membrane peeling was performed under PFCL. RESULTS: The amount of BBG dye with PFCL-assisted staining technique has the potential to be smaller than in conventional staining method...
September 2018: Japanese Journal of Ophthalmology
Hiroko Suzuki, Akiko Hikoya, Miwa Komori, Risako Inagaki, Takashi Haseoka, Shinji Arai, Yuri Takagi, Yoshihiro Hotta, Miho Sato
PURPOSE: To evaluate changes in conjunctival-scleral thickness following strabismus surgery with anterior segment optical coherence tomography (AS-OCT). STUDY DESIGN: Prospective, observational, consecutive case series. METHODS: Distances between the conjunctival epithelium and inner scleral wall were measured with AS-OCT before and 3-5 months after strabismus surgery. The measurements were performed at 1.5 mm (limbus), 7.0 mm (insertion), and 8...
September 2018: Japanese Journal of Ophthalmology
Nozomi Kinoshita, Yasuhiro Konno, Naoki Hamada, Yoshinobu Kanda, Machiko Shimmura-Tomita, Akihiro Kakehashi
PURPOSE: To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia. STUDY DESIGN: Prospective randomized clinical trial. METHODS: Japanese children aged 8-12 years with a spherical equivalent refractive error of - 1.00 to - 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0...
September 2018: Japanese Journal of Ophthalmology
Masashi Ogasawara, Hideki Koizumi, Akiko Yamamoto, Kanako Itagaki, Masaaki Saito, Ichiro Maruko, Annabelle A Okada, Tomohiro Iida, Tetsuju Sekiryu
PURPOSE: To determine factors predictive of visual outcomes in eyes treated with intravitreal aflibercept injections (IAIs) for typical neovascular age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, multicenter, institutional, consecutive, interventional case series. METHODS: One hundred nine eyes (107 patients) with treatment-naïve neovascular AMD at 3 university hospitals were studied...
September 2018: Japanese Journal of Ophthalmology
Kodai Inata, Dai Miyazaki, Ryu Uotani, Daisuke Shimizu, Atsuko Miyake, Yumiko Shimizu, Yoshitsugu Inoue
PURPOSE: To determine the efficacy of real-time PCR for the diagnosis and prognosis of varicella-zoster virus (VZV) keratitis. STUDY DESIGN: Retrospective case series. METHODS: Patients: 545 consecutive patients with keratitis were examined to quantify copy numbers of VZV DNA by real-time PCR. Association of copy numbers of VZV DNA to clinical signs and disease course was assessed by logistic regression analysis and Cox proportional hazard model...
July 2018: Japanese Journal of Ophthalmology
(no author information available yet)
PURPOSE: To review the clinical findings of retinoblastoma recorded over a period of 32 years by the National Registry of Retinoblastoma in Japan. STUDY DESIGN: Retrospective. METHODS: We reviewed the diagnoses, clinical pictures, and treatment data recorded on a yearly basis from 1983 until 2014 by major Japanese medical facilities. RESULTS: A total of 2360 patients (1225 boys, 1135 girls) were analyzed. Of those, 67...
July 2018: Japanese Journal of Ophthalmology
Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Makoto Nakamura
PURPOSE: To evaluate temporal changes in visual acuity in patients with steroid-resistant optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) after apheresis. DESIGN: Retrospective observational study, clinical case series SUBJECTS AND METHODS: We reviewed the medical charts of 15 eyes of 9 consecutive patients with ON in NMOSD who underwent apheresis between March 2010 and September 2017. All patients were seropositive for anti-aquaporin 4 (AQP4) antibody and resistant to steroid pulse therapy...
July 2018: Japanese Journal of Ophthalmology
Kenji Inoue, Kyoko Ishida, Goji Tomita
PURPOSE: To compare the effectiveness and safety of either switching from topical prostaglandin (PG) analog monotherapy to topical PG/timolol fixed combination therapy or adding topical ripasudil therapy. STUDY DESIGN: An open-label, prospective, randomized, parallel group, comparative study METHODS: Fifty-one patients (51 eyes) with primary open-angle glaucoma who experienced insufficient intraocular pressure (IOP) control while taking a PG analog were enrolled...
July 2018: Japanese Journal of Ophthalmology
Rie Tanaka, Toshikatsu Kaburaki, Kazuyoshi Ohtomo, Mitsuko Takamoto, Keiko Komae, Jiro Numaga, Yujiro Fujino, Makoto Aihara
PURPOSE: To investigate the clinical characteristics of Japanese patients with scleritis STUDY DESIGN: Retrospective study METHODS: The clinical records of 123 patients with scleritis, who presented to the University of Tokyo Hospital between January, 2004 and December, 2015, were retrospectively reviewed. RESULTS: The cohort comprised 55 men and 68 women (mean age, 57.8±16.4 years), of which 76 showed anterior diffuse scleritis, 17 showed anterior nodular scleritis, 10 showed anterior necrotizing scleritis, and 20 showed posterior scleritis...
July 2018: Japanese Journal of Ophthalmology
Akiko Maeda, Akiko Yoshida, Kanako Kawai, Yuki Arai, Ryutaro Akiba, Akira Inaba, Seiji Takagi, Ryoji Fujiki, Yasuhiko Hirami, Yasuo Kurimoto, Osamu Ohara, Masayo Takahashi
PURPOSE: Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy caused by different genetic variants. More than 60 causative genes have been identified to date. The establishment of cost-effective molecular diagnostic tests with high sensitivity and specificity can be beneficial for patients and clinicians. Here, we developed a clinical diagnostic test for RP in the Japanese population. STUDY DESIGN: Evaluation of diagnostic technology, Prospective, Clinical and experimental study...
July 2018: Japanese Journal of Ophthalmology
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