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Japanese Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28303357/long-term-surgical-outcome-of-conventional-trabeculotomy-for-childhood-glaucoma
#1
Hiroko Ozawa, Mio Yamane, Eisuke Inoue, Tomoyo Yoshida-Uemura, Satoshi Katagiri, Tadashi Yokoi, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To investigate the long-term surgical outcomes of conventional trabeculotomy in eyes with childhood glaucoma in a Japanese population. METHODS: In this retrospective observational study, we enrolled Japanese patients with childhood glaucoma who underwent a conventional trabeculotomy at least once before age 3 years from 1986 to 2014 in our hospital. RESULTS: One hundred seven eyes of 64 patients (24 girls, 40 boys; mean age, 2.8 ± 5...
March 16, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28280945/influence-of-intraocular-pressure-reduction-on-progression-of-normal-tension-glaucoma-with-myopic-tilted-disc-and-associated-risk-factors
#2
Bo Ram Seol, Soa Kim, Dong Myung Kim, Ki Ho Park, Jin Wook Jeoung, Seok Hwan Kim
Purpose To evaluate the influence of intraocular pressure (IOP) reduction on progression of normal-tension glaucoma (NTG) with myopic tilted disc and to demonstrate the associated risk factors. METHODS: The medical records on 109 eyes of 109 NTG patients with myopic tilted discs who were followed up for more than 5 years and treated with topical medications were reviewed. Glaucoma progression was defined according to either structural or functional deterioration. Patients were divided into tertile groups according to the percent IOP reduction from the baseline, and the cumulative probability of NTG nonprogression of the upper- and lower-tertile groups was compared using Kaplan-Meier survival analysis...
March 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28271229/characteristics-of-patients-with-spontaneous-dislocation-of-in-the-bag-intraocular-lens-after-pars-plana-vitrectomy
#3
Takayuki Koike, Takayuki Baba, Tomohiro Nizawa, Toshiyuki Oshitari, Shuichi Yamamoto
PURPOSE: To determine the characteristics of eyes with late in-the-bag dislocation of an intraocular lens (IOL) after pars plana vitrectomy (PPV). METHODS: Fourteen eyes of 14 patients with a dislocated IOL after PPV were studied retrospectively. The data collected from the medical charts included the age, sex, history of eye diseases, axial length, and interval from PPV to time of IOL dislocation. The surgical procedures used during the PPV were also recorded. RESULTS: Seven eyes had undergone PPV for rhegmatogenous retinal detachment; 6 eyes, for proliferative diabetic retinopathy; and 1 eye, for retinal vein occlusion...
March 7, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28229342/the-prevalence-and-types-of-strabismus-and-average-of-stereopsis-in-japanese-adults
#4
Toshiaki Goseki, Hitoshi Ishikawa
PURPOSE: Few studies report the prevalence and types of strabismus, or average of stereopsis in Japanese adults. We performed ophthalmological evaluation including motility and stereopsis during medical examinations at cooperative companies. METHODS: We studies 1214 volunteers. The average age was 41.2 ± 12.6 (range 20-86) years. Examinations were carried out using their customary eyewear, evaluating alternate prism cover test (APCT), and Titmus stereo test (TST)...
February 22, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28197741/correlation-between-the-col4a3-mmp-9-and-timp-1-polymorphisms-and-risk-of-keratoconus
#5
Ramin Saravani, Davood Yari, Samira Saravani, Farzaneh Hasanian-Langroudi
PURPOSE: Keratoconus (KC) is thinning of the central cornea. Its etiology is unknown, but it may result from degrading of collagen type IV. The major protein in the cornea is collagen. Matrix metalloproteinase-9 (MMP-9) is able to degrade collagen type IV from the basement membrane and extracellular matrix (ECM). MMP-9 enzymatic activity is inhibited by the tissue inhibitor of metalloproteinase-1 (TIMP-1). In the present study, we sought to investigate and evaluate the effects of single nucleotide polymorphisms in COL4A3, MMP-9, and TIMP-1 on the risk of KC in an Iranian population sample...
February 14, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28197740/characteristics-of-successful-filtering-blebs-at-1%C3%A2-year-after-trabeculectomy-using-swept-source-three-dimensional-anterior-segment-optical-coherence-tomography
#6
Akiko Narita, Yuki Morizane, Tomoe Miyake, Jiro Seguchi, Tetsuya Baba, Fumio Shiraga
PURPOSE: To identify the cross-sectional characteristics of filtering blebs associated with intraocular pressure (IOP) control at 1 year after trabeculectomy with a square scleral flap and a fornix-based conjunctival flap. METHODS: A retrospective consecutive case series study was conducted. Eighty-four eyes of 79 patients who had undergone primary trabeculectomy were included. Surgical success was defined as IOP ≤15 mmHg and a >20% reduction in IOP without glaucoma medication and without additional glaucoma surgery at 1 year after trabeculectomy...
February 14, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28188406/comparative-study-of-plication-recession-versus-resection-recession-in-unilateral-surgery-for-intermittent-exotropia
#7
Yugo Kimura, Tohru Kimura
PURPOSE: Plication is a muscle-strengthening procedure in which a muscle is not dissected from its point of insertion. The purpose of this study was to compare the results of plication-recession (PR) with those of resection-recession (RR) in adult patients with intermittent exotropia (XT). METHODS: Patients with XT who underwent either PR or RR with a minimum postoperative follow-up of 12 months were retrospectively reviewed. Postoperative mean distance deviation and surgical outcomes were compared at 1 week and at 1, 3, 6, and 12 months, and at the final follow-up...
February 10, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28188405/success-rates-of-2-site-phacoemulsification-combined-with-fornix-based-trabeculectomy-using-mitomycin-c-for-primary-angle-closure-glaucoma-and-primary-open-angle-glaucoma-in-an-asian-population
#8
Victor Koh, David Chen, Cecilia Maria Aquino, Joel Aduan, Chelvin Sng, Loon Seng Chee, Paul Chew
PURPOSE: To determine the long-term outcomes of 2-site phacoemulsification combined with fornix-based trabeculectomy using mitomycin C (MMC) for primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) in an Asian population. METHODS: We reviewed the records of all patients with POAG or PACG who underwent phacoemulsification with trabeculectomy using MMC from January 2008 through December 2010 in a tertiary ophthalmology unit in Singapore. The primary outcome measure was cumulative success rates defined as complete [intraocular pressure (IOP) <21, 18, 15 mmHg without medication] and qualified (IOP <21, 18, 15 mmHg with at least 1 medication) success...
February 10, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28185066/optic-disc-rim-and-peripapillary-chorioretinal-atrophy-in-normal-japanese-eyes-the-kumejima-study
#9
Aiko Iwase, Shoichi Sawaguchi, Hiroshi Sakai, Kenji Tanaka, Tae Tsutsumi, Makoto Araie
PURPOSE: To report reference data for optic disc, neuroretinal rim and β-peripapillary atrophy (β-PPA) in normal Japanese. METHODS: In the Kumejima study, all participants underwent disc stereo-photography; 2208 normal subjects had good-quality disc stereo and β-PPA photographs OU. The disc and rim area and the area and angular extent of β-PPA were evaluated by computer-assisted planimetry. RESULTS: The disc, rim, and β-PPA area and its angular extent OD (OS) averaged 2...
February 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28176021/visual-characteristics-of-children-with-down-syndrome
#10
Kaoru Tomita
PURPOSE: To analyze long-term visual development in children with Down syndrome who received early ophthalmological intervention. METHODS: A total of 125 children with Down syndrome who were examined before 6 years of age and followed up for more than 5 years were selected. Visual development, refraction, visual acuity testing, and the prescription of spectacles were examined retrospectively. RESULTS: Mean visual acuity by age was as follows: 2 years, 1...
February 7, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28154953/half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy-evaluated-by-focal-macular-electroretinograms
#11
Kazuhiro Oiwa, Keiko Kataoka, Ruka Maruko, Shinji Ueno, Yasuki Ito, Hiroko Terasaki
PURPOSE: To evaluate the effect of half-dose verteporfin photodynamic therapy (hPDT) on the physiology of the macula determined by focal macular electroretinograms (FMERGs) in eyes with chronic central serous chorioretinopathy (CSC). METHODS: Fourteen eyes of 13 patients with chronic CSC were treated with hPDT. The best-corrected visual acuity (BCVA) was measured, and optical coherence tomography (OCT) and FMERGs were performed at the baseline, and at 4 days, 1, 3, 6, and 12 months after the hPDT...
February 2, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28097453/seven-cases-of-localized-invasive-sino-orbital-aspergillosis
#12
Hideaki Kawakami, Kiyofumi Mochizuki, Kyoko Ishida, Kiyofumi Ohkusu
PURPOSE: To describe the clinical manifestations and prognoses in 7 patients with invasive sino-orbital aspergillosis (ISOA). METHODS: This was a retrospective study of consecutive patients who were diagnosed as having ISOA at the Gifu University Hospital and Gifu Municipal Hospital between January 1993 and December 2015. Data were collected on demographics, initial manifestations, examination findings, treatments, clinical course, and outcomes. RESULTS: The median age of the 7 patients with ISOA was 68 years; 5 of them had diabetes...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28091897/comparative-analysis-of-the-visual-and-refractive-outcomes-of-a-refractive-segmented-multifocal-intraocular-lens-with-and-without-toricity-1-year-results
#13
Ryo Shodai, Kazuno Negishi, Hiroyuki Arai, Ikuko Toda, Hidemasa Torii, Kazuo Tsubota
PURPOSE: To compare the visual and refractive outcomes up to 1 year postoperatively following implantation of a refractive segmented or a refractive segmented toric multifocal intraocular lens (IOL). METHODS: This retrospective study included 108 eyes of 64 patients who underwent cataract surgery with implantation of a refractive segmented multifocal IOL (Lentis Mplus LS-313 MF30 IOL) (LM group) and 81 eyes of 49 patients with implantation of a refractive segmented toric multifocal IOL (Lentis Mplus LU-313 MF30T IOL) (LMT group)...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28062929/epidemiology-treatment-pattern-and-health-care-utilization-of-myopic-choroidal-neovascularization-a-population-based-study
#14
Ming-Chin Yang, Yen-Po Chen, Elise Chia-Hui Tan, Claudia Leteneux, Erin Chang, Carol Hy Chu, Chi-Chun Lai
PURPOSE: To investigate the prevalence and incidence of myopic choroidal neovascularization (CNV) in Taiwan, including the health care utilization and treatment-associated costs. METHODS: A retrospective cohort study using existing data from the Taiwanese National Health Insurance claims database to identify patients who had a diagnosis of myopic CNV recorded from 1 January 2009 to 31 December 2011. The prevalence of myopic CNV was monitored during this period, and the frequency and cost of both treatment visits and monitoring visits were analyzed for 2 years following diagnosis...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28062928/evaluation-of-paraxial-forward-scattering-from-intraocular-lens-with-increased-surface-light-scattering-using-goniophotometry-and-hartmann-shack-wavefront-aberrometry
#15
Keiichiro Minami, Yoko Maruyama, Toshifumi Mihashi, Kazunori Miyata, Tetsuro Oshika
PURPOSE: To evaluate the influence of increases in light scattering on intraocular lens (IOL) surfaces on paraxial forward scattering using goniophotometry and Hartmann-Shack wavefront aberrometry. METHODS: Surface light scattering was reproduced experimentally by acceleratedly aging 4 intraocular lenses by 0, 3, 5, and 10 years each. Light scattering from both IOL surfaces was measured using Scheimpflug photography. The paraxial forward scattering from the aged IOLs was measured using a goniophotometer with a halogen light source (wavelength: 350-850 nm) and telecentric optics, and changes in the maximum intensity and full width at 10% of maximum intensity (FW10%) were evaluated...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28032230/protective-effect-of-p7c3-on-retinal-ganglion-cells-from-optic-nerve-injury
#16
Hidehiro Oku, Seita Morishita, Taeko Horie, Yuko Nishikawa, Teruyo Kida, Masashi Mimura, Shota Kojima, Tsunehiko Ikeda
PURPOSE: To determine whether P7C3-A20, a proneurogenic neuroprotective agent, can protect the retinal ganglion cells (RGCs) of rats from optic nerve crushing. METHODS: The left optic nerve of 67 rats was crushed, and 5.0 mg/kg/day of P7C3-A20 (crush-P7C3) or its vehicle (crush-placebo) was injected intraperitoneally for 3 days from one day prior to the crushing. The protective effects were determined by the number of Tuj-1-stained RGCs and by the ratio of the mRNA levels of BAX/Bcl-2 on day 7...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27943090/evaluation-of-factors-affecting-visual-acuity-after-descemet-stripping-automated-endothelial-keratoplasty
#17
Shiro Amano, Akira Setogawa, Kenji Inoue
PURPOSE: To elucidate the factors affecting visual acuity after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: We reviewed consecutive patients who underwent primary DSAEK for corneal endothelial dysfunction at Inouye Eye Hospital from January 2010 through January 2015 and who had a follow-up of at least 6 months. Fifty-four eyes of 49 patients (24 men and 25 women) were enrolled; the mean age was 72.5 ± 8.7 years. Medical charts were retrospectively examined for best spectacle-corrected visual acuity (BSCVA), intraocular pressure, keratometric value, keratometric cylinder, grade of preoperative corneal edema, preoperative graft thickness, and endothelial cell density (ECD) before and at 1, 3, 6, 12, and 24 months after surgery...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27943089/diltiazem-co-treatment-with-cyclosporine-for-induction-of-disease-remission-in-sight-threatening-non-infectious-intraocular-inflammation
#18
RANDOMIZED CONTROLLED TRIAL
Usama Shalaby
PURPOSE: To investigate the effects of diltiazem co-treatment with microemulsified cyclosporine-A (CsA) on dosage, blood concentrations of CsA, as well as therapeutic and side effects in patients with sight-threatening non-infectious intraocular inflammation. METHODS: A prospective, randomized, placebo-controlled, open-label trial of 39 patients with sight-threatening non-infectious intraocular inflammation. The change in visual acuity (LogMAR), the grade of inflammatory activity, therapeutic concentration of CsA in the blood and systemic and renal toxicity were determined after comparing two groups, one treated with CsA and diltiazem (treatment group), and the other without diltiazem (control group)...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27928695/one-year-outcomes-of-a-treat-and-extend-regimen-of-intravitreal-aflibercept-for-polypoidal-choroidal-vasculopathy
#19
Mio Hosokawa, Yuki Morizane, Masayuki Hirano, Shuhei Kimura, Fumiaki Kumase, Yusuke Shiode, Shinichiro Doi, Shinji Toshima, Mika Hosogi, Atsushi Fujiwara, Toshiharu Mitsuhashi, Fumio Shiraga
PURPOSE: To evaluate the 1-year treatment outcomes of intravitreal aflibercept injections (IVA) using a treat-and-extend regimen for polypoidal choroidal vasculopathy (PCV). METHODS: Thirty-seven eyes with treatment-naive PCV treated with IVA using a treat-and-extend regimen for 1 year were reviewed retrospectively. The main outcome measures were changes in the best-corrected visual acuity (BCVA) and central retinal thickness (CRT), and the treatment interval at 1 year...
March 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27885526/twelve-year-follow-up-of-penetrating-keratoplasty
#20
Takashi Ono, Sosuke Ishiyama, Takeshi Hayashidera, Yosai Mori, Ryohei Nejima, Kazunori Miyata, Shiro Amano
PURPOSE: To evaluate the long-term outcomes of penetrating keratoplasty (PKP) according to the corneal disease diagnosis and the number of PKP procedures performed. METHODS: Five-hundred-and-nine eyes from 403 patients who underwent PKP at Miyata Eye Hospital in Japan from 1998 through 2014, were included in this study. Medical charts were retrospectively examined to ascertain the corneal disease diagnosis and the period of graft survival. Graft survival rates were compared among various corneal disease diagnoses and among the number of PKP procedures performed...
March 2017: Japanese Journal of Ophthalmology
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