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Japanese Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28725984/cytokine-expression-and-barrier-disruption-in-human-corneal-epithelial-cells-induced-by-alarmin-released-from-necrotic-cells
#1
Ken Fukuda, Waka Ishida, Yusaku Miura, Tatsuma Kishimoto, Atsuki Fukushima
PURPOSE: Dying cells release endogenous molecules known as alarmins that signal danger to surrounding tissue. We investigated the effects of necrotic cell-derived alarmins on cytokine expression and barrier function in human corneal epithelial cells. METHODS: The release of interleukin (IL)-6 and IL-8 from immortalized human corneal epithelial (HCE) cells in culture was measured with enzyme-linked immunosorbent assays. The abundance of IL-6 and 8 mRNAs was quantitated by reverse transcription and real-time polymerase chain reaction analysis...
July 19, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28707018/postoperative-enterococcus-faecalis-endophthalmitis-virulence-factors-leading-to-poor-visual-outcome
#2
Daisuke Todokoro, Takashi Suzuki, Shinichiro Kobayakawa, Haruyoshi Tomita, Yuichi Ohashi, Hideo Akiyama
Purpose Postoperative endophthalmitis caused by Enterococcus faecalis often results in poor visual outcome due to retinal destruction. We evaluated the virulence factors of Enterococcus faecalis clinical isolates and analyzed their relationship with retinal destruction and poor visual outcomes in postoperative bacterial endophthalmitis (PBE) following cataract surgery. STUDY DESIGN: Retrospective. METHODS: E. faecalis isolates from nine acute-onset PBE cases were examined using pulsed-field gel electrophoresis of genomic DNA, plasmid isolation and pheromone response experiments...
July 13, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28668999/heterozygous-deletion-of-the-opa1-gene-in-patients-with-dominant-optic-atrophy
#3
Takaaki Hayashi, Hiroyuki Sasano, Satoshi Katagiri, Kazushige Tsunoda, Shuhei Kameya, Mitsuru Nakazawa, Takeshi Iwata, Hiroshi Tsuneoka
PURPOSE: Several OPA1 variants cause dominant optic atrophy (DOA), the most common hereditary optic atrophy. Here, we describe a newly discovered OPA1 deletion in 3 patients with DOA. METHODS: A female proband, her brother, and her mother underwent complete ophthalmologic examinations that included optical coherence tomography and visual field assessments using a Humphrey Field Analyzer with both standard automated perimetry (SAP) and short-wavelength automated perimetry (SWAP)...
July 1, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28667424/evaluating-retinal-vessel-diameter-with-optical-coherence-tomography-in-normal-tension-glaucoma-patients
#4
Takeshi Yabana, Yukihiro Shiga, Ryo Kawasaki, Kazuko Omodaka, Hidetoshi Takahashi, Koudai Kimura, Kyosuke Togashi, Takaaki Horii, Kei Sasaki, Testuya Yuasa, Toru Nakazawa
PURPOSE: To investigate a novel optical coherence tomography (OCT)-derived variable, circumpapillary mean retinal shadow width (cpMRSW), and to elucidate its association with normal-tension glaucoma (NTG). METHODS: For the purpose of validation, we measured retinal vascular calibers in 68 arterioles and 100 venules of 12 NTG patients and 12 healthy subjects and compared the width of the visible retinal shadows in spectral-domain OCT images and the caliber of retinal vessels in retinal photographs...
June 30, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28653193/effects-of-ripasudil-hydrochloride-hydrate-k-115-a-rho-kinase-inhibitor-on-ocular-blood-flow-and-ciliary-artery-smooth-muscle-contraction-in-rabbits
#5
Yusuke Ohta, Sanae Takaseki, Takeshi Yoshitomi
PURPOSE: Ripasudil, a Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor, is a novel drug for glaucoma in Japan. ROCK inhibition not only reduces intraocular pressure (IOP) but also increases ocular blood flow. We investigated the effects of ripasudil on optic disc blood flow (ODBF) in rabbit eyes and in isolated rabbit ciliary arteries. METHODS: We measured IOP by tonometry and ODBF by laser speckle flowgraphy (LSFG) in male Dutch rabbits. A single drop (20 μL) of 0...
June 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28600745/safety-and-effectiveness-of-gold-glaucoma-micro-shunt-for-reducing-intraocular-pressure-in-japanese-patients-with-open-angle-glaucoma
#6
Masaki Tanito, Etsuo Chihara
PURPOSE: To assess the safety and effectiveness of the SOLX gold shunt (GS) in reducing intraocular pressure (IOP) in Japanese patients with open angle glaucoma (OAG). METHODS: 24 eyes of 24 subjects [mean age of 68.9 ± 12.7 years; 13 (54%) women; 16 (67%) POAG, 7 (29%) pseudoexfoliation glaucoma, and 1 (4%) steroid response glaucoma] were implanted with the GS either with or without cataract surgery. Best-corrected visual acuity (BCVA), IOP, corneal endothelial cell density (CECD), anterior chamber (AC) flare, surgical complications, and required interventions were monitored at baseline, and 1 day, 1 week, 1, 3 and 6 months, and 1 year postoperatively...
June 9, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28597192/pre-banking-microbial-contamination-of-donor-conjunctiva-and-storage-medium-for-penetrating-keratoplasty
#7
Takenori Inomata, Koichi Ono, Tsuyoshi Matsuba, Tina Shiang, Antonio Di Zazzo, Satoru Nakatani, Masahiro Yamaguchi, Nobuyuki Ebihara, Akira Murakami
PURPOSE: The aims of this study were to investigate the incidence of positive donor tissue cultures before transfer to preservation medium (Optisol™-GS) for penetrating keratoplasty, to verify the efficacy of antibiotics contained in Optisol™-GS by examining the drug susceptibility and to assess the relationship between the results of our microbial assessments as well as donor factors and the incidence of contamination. METHODS: We conducted a retrospective, cross-sectional study using Juntendo Eye Bank records for all corneal transplantations...
June 8, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28466097/distant-stereoacuity-in-children-with-anisometropic-amblyopia
#8
Yeon Woong Chung, Shin Hae Park, Sun Young Shin
PURPOSE: To characterize changes in distant stereoacuity using Frisby-Davis Distance test (FD2) and Distant Randot test (DR) during treatment for anisometropic amblyopia, to determine factors that influence posttreatment stereoacuity and to compare the two distant stereotests. METHODS: Fifty-eight anisometropic amblyopic patients with an interocular difference of ≥1.00 diopter who achieved the visual acuity 20/20 following amblyopia treatment were retrospectively included...
May 2, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28550431/impact-of-intraocular-pressure-reduction-on-visual-field-progression-in-normal-tension-glaucoma-followed-up-over-15%C3%A2-years
#9
Shinya Oie, Kyoko Ishida, Tetsuya Yamamoto
PURPOSE: To investigate the impact of surgical or medical reduction of intraocular pressure (IOP) on progressive normal-tension glaucoma followed up over 15 years. METHODS: Sixty eyes of 60 patients were divided into 3 intervention groups: group 1 (trabeculectomy, n = 17); group 2 (IOP reduction rate ≥15% with prostaglandin analogs, n = 24); and group 3 (IOP reduction rate <15% with prostaglandin analogs, n = 19). The preintervention and postintervention mean deviation (MD) slopes and IOP were compared...
July 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28197741/correlation-between-the-col4a3-mmp-9-and-timp-1-polymorphisms-and-risk-of-keratoconus
#10
Ramin Saravani, Davood Yari, Samira Saravani, Farzaneh Hasanian-Langroudi
PURPOSE: Keratoconus (KC) is thinning of the central cornea. Its etiology is unknown, but it may result from degrading of collagen type IV. The major protein in the cornea is collagen. Matrix metalloproteinase-9 (MMP-9) is able to degrade collagen type IV from the basement membrane and extracellular matrix (ECM). MMP-9 enzymatic activity is inhibited by the tissue inhibitor of metalloproteinase-1 (TIMP-1). In the present study, we sought to investigate and evaluate the effects of single nucleotide polymorphisms in COL4A3, MMP-9, and TIMP-1 on the risk of KC in an Iranian population sample...
May 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28447271/the-relationship-between-vascular-endothelial-dysfunction-and-treatment-frequency-in-neovascular-age-related-macular-degeneration
#11
Tomoko Ueda-Consolvo, Atsushi Hayashi, Mayumi Ozaki, Tomoko Nakamura, Takaaki Yagou, Shinya Abe
PURPOSE: To assess the correlation between endothelial dysfunction and frequency of antivascular endothelial growth factor (anti-VEGF) treatment for neovascular age-related macular degeneration (nAMD). METHODS: We examined 64 consecutive patients with nAMD who were evaluated for endothelial function by use of peripheral arterial tonometry (EndoPAT 2000; Itamar Medical, Caesarea, Israel) at Toyama University Hospital from January 2015. We tallied the number of anti-VEGF treatments between January 2014 and December 2015 and determined the correlation between the number of anti-VEGF injections and endothelial function expressed as the reactive hyperemia index (RHI)...
April 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28447270/annual-incidences-of-visual-impairment-during-10-year-period-in-mie-prefecture-japan
#12
Kengo Ikesugi, Takako Ichio, Hideyuki Tsukitome, Mineo Kondo
PURPOSE: To determine the annual incidence of visual impairment in a Japanese population during a 10-year period. METHODS: We examined the physical disability certificates issued yearly between 2004 and 2013 in Mie prefecture, Japan. During this period 2468 visually impaired people were registered under the newly defined Act on Welfare of the Physically Disabled Persons' criteria. The age, sex distribution, and causes of visual impairment were determined from the certificates...
April 26, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28444485/evaluation-of-kinetic-programs-in-various-automated-perimeters
#13
Shigeki Hashimoto, Chota Matsumoto, Mariko Eura, Sachiko Okuyama, Yoshikazu Shimomura
PURPOSE: Kinetic programs in four automated perimeters were evaluated and compared for their clinical usefulness using four simulated visual field (VF) patterns. METHODS: Using the results of conventional Goldmann manual kinetic perimetry (MKP), simulated fields with concentric contraction, a temporal residual island only, a small central island with a temporal island, and a ring scotoma were created. Four kinetic programs, Humphrey 750i Kinetic Test (Humphrey), OCULUS Twinfield 2 Kinetic Perimetry (OCULUS), OCTOPUS 900 Goldmann Kinetic Perimetry (OCTOPUS GKP), and Kowa AP-7000 Isopter (Kowa) were tested by the 4 simulated defect patterns using stimuli of V/4e, I/4e, I/3e, I/2e, and I/1e at speeds of 3 and 5°/s...
April 25, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28421369/immunophenotypic-profiles-for-distinguishing-orbital-mucosa-associated-lymphoid-tissue-lymphoma-from-benign-lymphoproliferative-tumors
#14
Shunichiro Ueda, Yoshihiko Usui, Takeshi Nagai, Daniel Diaz-Aguilar, Toshitaka Nagao, Hiroshi Goto
PURPOSE: To evaluate novel immunophenotypic profiles of patients with orbital lymphoproliferative tumors. METHODS: From 2006 to 2014, surgical biopsies from consecutive patients with newly diagnosed orbital mucosa-associated lymphoid tissue (MALT) lymphoma and IgG4-related ophthalmic disease (IgG4-ROD) were collected from Tokyo Medical University Hospital. A total of 44 tumors from 44 patients were analyzed, including 21 with orbital MALT lymphoma (11 men and 10 women, mean age 67...
April 18, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28389894/upper-fornix-approach-combined-with-a-superior-lateral-cantholysis-a-minimally-invasive-approach-to-the-superonasal-intraconal-space
#15
Ho-Seok Sa, Ji Won Seo, Sunah Kang
PURPOSE: To present a new minimally invasive approach to the deep superonasal orbit. METHODS: This retrospective study reviewed seven consecutive patients who underwent orbital surgery using an upper conjunctival fornix approach combined with a superior lateral cantholysis for tumors in the superonasal intraconal space. Charts were reviewed for demographic, radiological, clinical, and surgical data including surgical outcome and morbidities for each patient. RESULTS: Six benign tumors of the superonasal intraconal orbit were successfully exposed and removed using this approach, and one malignant tumor was biopsied for diagnosis...
April 7, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28374270/patterns-of-glaucoma-progression-in-retinal-nerve-fiber-and-macular-ganglion-cell-inner-plexiform-layer-in-spectral-domain-optical-coherence-tomography
#16
Hae Jin Kim, Jin Wook Jeoung, Byeong Wook Yoo, Hee Chan Kim, Ki Ho Park
PURPOSE: To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma. METHODS: One hundred-fourteen eyes of open-angle glaucoma patients with localized RNFL defect who had 3 years' worth of annual RNFL photography and OCT measurements were enrolled in this retrospective study...
April 3, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28374269/effect-of-glaucoma-implant-surgery-on-intraocular-pressure-reduction-flare-count-anterior-chamber-depth-and-corneal-endothelium-in-primary-open-angle-glaucoma
#17
Kyoko Ishida, Naoya Moroto, Kazuhiro Murata, Tetsuya Yamamoto
PURPOSE: To evaluate the effect of filtering surgery using the EX-PRESS device on intraocular pressure (IOP), flare count, anterior chamber (AC) depth, and the corneal endothelium in primary open-angle glaucoma (POAG), including normal-tension glaucoma (NTG). PATIENTS AND METHODS: The study comprised 63 consecutive patients with POAG or NTG. They underwent complete ophthalmologic examinations, including measurement of visual acuity (VA), IOP, flare count, AC depth, and cell density of the corneal endothelium (CE)...
April 3, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28374268/the-challenging-management-of-pediatric-corneal-transplantation-an-overview-of-surgical-and-clinical-experiences
#18
REVIEW
Antonio Di Zazzo, Stefano Bonini, Salvatore Crugliano, Michele Fortunato
PURPOSE: Pediatric keratoplasty is an immense challenge because of the technical complexity of the procedure and the high risk of rejection in young graft recipients. Our aim is to describe the major indications and appropriate timing of corneal transplantation intervention, including a report of our experience and surgical tips, in conjunction with the current literature. METHODS: Review of the literature on indications for keratoplasty in pediatric patients classified as: congenital, traumatic and acquired non-traumatic opacities...
April 3, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28357611/development-of-visual-field-defect-after-first-detected-optic-disc-hemorrhage-in-preperimetric-open-angle-glaucoma
#19
Hae Jin Kim, Yong Ju Song, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To evaluate functional progression in preperimetric glaucoma (PPG) with disc hemorrhage (DH) and to determine the time interval between the first-detected DH and development of glaucomatous visual field (VF) defect. METHODS: A total of 87 patients who had been first diagnosed with PPG were enrolled. The medical records of PPG patients without DH (Group 1) and with DH (Group 2) were reviewed. When glaucomatous VF defect appeared, the time interval from the diagnosis of PPG to the development of VF defect was calculated and compared between the two groups...
March 29, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28303357/long-term-surgical-outcome-of-conventional-trabeculotomy-for-childhood-glaucoma
#20
Hiroko Ozawa, Mio Yamane, Eisuke Inoue, Tomoyo Yoshida-Uemura, Satoshi Katagiri, Tadashi Yokoi, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To investigate the long-term surgical outcomes of conventional trabeculotomy in eyes with childhood glaucoma in a Japanese population. METHODS: In this retrospective observational study, we enrolled Japanese patients with childhood glaucoma who underwent a conventional trabeculotomy at least once before age 3 years from 1986 to 2014 in our hospital. RESULTS: One hundred seven eyes of 64 patients (24 girls, 40 boys; mean age, 2.8 ± 5...
March 16, 2017: Japanese Journal of Ophthalmology
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