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Japanese Journal of Ophthalmology

Eri Kinoshita-Nakano, Hideo Nakanishi, Hanako Ohashi-Ikeda, Satoshi Morooka, Tadamichi Akagi
PURPOSE: To compare clinical outcomes between trabeculotomy ab externo (TLO) and trabecular ablation ab interno using a Trabectome (TAT) for open angle glaucoma (OAG). STUDY DESIGN: Prospective and retrospective cohort study. METHODS: We prospectively recruited 68 patients who underwent TAT between May 2013 and July 2015, and retrospectively recruited 59 patients who underwent TLO between April 2010 and May 2013. We included OAG patients who could be followed up for more than 12 months after surgery...
January 5, 2018: Japanese Journal of Ophthalmology
Kentaro Kurata, Katsuhiro Hosono, Yoshihiro Hotta
PURPOSE: To assess the long-term clinical course of 2 patients with PRPF31-related retinitis pigmentosa (RP). PATIENTS AND METHODS: We clinically examined 2 unrelated patients with RP and collected peripheral blood samples from them. Ophthalmic examinations, including best-corrected visual acuity measurements, Goldmann perimetry, full-field electroretinography, fundus autofluorescence imaging, and optical coherence tomography, were also performed. The visual acuity and visual field were continuously monitored...
January 5, 2018: Japanese Journal of Ophthalmology
Akitaka Tsujikawa, Yumiko Akagi-Kurashige, Mitsuko Yuzawa, Tatsuro Ishibashi, Hideo Nakanishi, Eiji Nakatani, Satoshi Teramukai, Masanori Fukushima, Nagahisa Yoshimura
PURPOSE: To report research participants' baseline characteristics in the AMD2000 study, a prospective, multicenter, 5-year, observational cohort study of Japanese age-related macular degeneration (AMD). The characteristics were determined using multimodal imaging. METHODS: Patients with AMD were recruited at 18 clinical sites in Japan between April 2006 and March 2009. Each patient underwent a complete ophthalmic examination, including measurement of best-corrected visual acuity (Landolt chart), indirect ophthalmoscopy, slit-lamp biomicroscopy with a contact lens, optical coherence tomography imaging, fundus photography, and fluorescein and indocyanine green angiography...
December 21, 2017: Japanese Journal of Ophthalmology
Shozo Sonoda, Taiji Sakamoto, Naoko Kakiuchi, Hideki Shiihara, Tomonori Sakoguchi, Masatoshi Tomita, Takehiro Yamashita, Eisuke Uchino
PURPOSE: To determine the capabilities of "EyeGround" software in measuring the choroidal cross sectional areas in optical coherence tomographic (OCT) images. STUDY DESIGN: Cross sectional, prospective study. METHODS: The cross-sectional area of the subfoveal choroid within a 1500 µm diameter circle centered on the fovea was measured both with and without using the EyeGround software in the OCT images. The differences between the evaluation times and the results of the measurements were compared...
December 21, 2017: Japanese Journal of Ophthalmology
Sang Wook Jin, Sae Mi Lee
PURPOSE: To compare longitudinal changes in circumpapillary retinal nerve fiber layer (cpRNFL) and ganglion cell complex (GCC) thicknesses and factors that are related to changes in cpRNFL and GCC thicknesses after acute primary angle closure (APAC). STUDY DESIGN: A prospective consecutive case series. METHODS: This study was a prospective, consecutive case series study including 64 eyes of 64 subjects with APAC. cpRNFL and GCC thicknesses were measured by RTVue-100 OCT...
December 21, 2017: Japanese Journal of Ophthalmology
Nanami Nomi, Manami Ota, Miho Fukumura, Yoshihisa Nuno, Makoto Hatano, Makiko Wakuta, Ryoji Yanai, Kazuhiro Kimura
PURPOSE: To report 2 cases of paclitaxel-related maculopathy manifesting as cystoid macular edema (CME) with late petaloid hyperfluorescence on indocyanine green angiography (IA). CASES: A 74-year-old man (patient 1) undergoing paclitaxel chemotherapy for gastric and metastatic liver cancer and a 69-year-old man (patient 2) receiving paclitaxel for hypopharyngeal cancer presented with anorthopia in both eyes. Spectral domain-optical coherence tomography (SD-OCT) revealed macular edema in both eyes of each patient...
December 21, 2017: Japanese Journal of Ophthalmology
Hiroko Bissen-Miyajima, Manabu Hirasawa, Kunihiko Nakamura, Yuka Ota, Keiichiro Minami
PURPOSE: To assess the safety and efficacy of femtosecond laser-assisted cataract surgery (FLACS) in Japanese eyes. STUDY DESIGN: Retrospective case series. METHODS: The clinical records of 529 consecutive eyes of 312 Japanese patients who underwent FLACS from 2013 to 2016 were reviewed. The completion rates of anterior capsulotomy and corneal incisions using the femtosecond laser (LenSx, Alcon) and the number of attempts to achieve secure docking between the cornea and laser system were recorded...
December 20, 2017: Japanese Journal of Ophthalmology
Yumiko Akagi-Kurashige, Akitaka Tsujikawa, Mitsuko Yuzawa, Tatsuro Ishibashi, Hideo Nakanishi, Eiji Nakatani, Satoshi Teramukai, Masanori Fukushima, Nagahisa Yoshimura
PURPOSE: In this study (AMD2000), we aimed to determine the visual prognosis of Japanese patients with age-related macular degeneration (AMD). METHODS: This was a multicenter prospective observational cohort study. In total, 460 patients with AMD were recruited from April 2006 to March 2009 from 18 clinical trial sites in Japan. They were followed up for 5 years, as they continued to receive medical treatment. RESULTS: Of the 409 study eyes followed up for at least 1 year, 243 eyes (59...
December 9, 2017: Japanese Journal of Ophthalmology
Hiroko Terasaki, Yuichiro Ogura, Shigehiko Kitano, Taiji Sakamoto, Toshinori Murata, Akito Hirakata, Tatsuro Ishibashi
Diabetic retinopathy is a frequent cause of visual impairment in working-age adults (≥ 30 years) and in Japan is most commonly observed in those aged 50-69 years. Diabetic macular edema (DME) is one of the main causes of vision disturbance in diabetic retinopathy, which is a clinically significant microvascular complication of diabetes. Anti-vascular endothelial growth factor (VEGF) therapy is becoming the mainstay of treatment for DME. However, to achieve sustained long-term improvement in visual acuity, conventional laser photocoagulation, vitrectomy and steroid therapy are also expected to play a role in the treatment of DME...
December 5, 2017: Japanese Journal of Ophthalmology
Taichi Kawamura, Izumi Sato, Hiroshi Tamura, Yoko M Nakao, Koji Kawakami
AIMS: To investigate the influence of comorbidities on undergoing a diabetic eye examination in patients with newly diagnosed type 2 diabetes mellitus (T2DM). DESIGN: Retrospective cohort study METHODS: This was a retrospective cohort study using data from health insurance claims made between January 2005 and March 2013 in Japan. The primary outcome was implementation of the fundus examination that includes fundus photography, ophthalmoscopy and optical coherence tomography by a doctor within one year of initial drug therapy for Type2 Diabetes Mellitus (T2DM)...
December 5, 2017: Japanese Journal of Ophthalmology
Louis F Dell'Osso, Suber S Huang
PURPOSE: To report and discuss a focal oscillopsia in a small area of the visual field produced by, and after the removal of, an epiretinal membrane (ERM) in an individual with infantile nystagmus syndrome (INS) since birth with no associated afferent visual deficits. STUDY DESIGN: A retrospective case report. METHODS: A chart review, including clinical and electrophysiological data. A 74 y/o man with INS and an epiretinal membrane was studied...
December 5, 2017: Japanese Journal of Ophthalmology
Isabel Pinilla Lozano, Carmen López de la Fuente, Francisco Segura, Elvira Orduna Hospital, Ana Sánchez-Cano
PURPOSE: To evaluate several anterior chamber parameters in healthy young adults using spectral-domain optical coherence tomography and to describe the repeatability and reproducibility of this method. STUDY DESIGN: Prospective clinical study. METHODS: Fifty-two eyes of 52 healthy volunteers were enrolled. Manual measurements of the anterior chamber angle (ACA500 and ACA750), angle opening distance (AOD500 and AOD750), angle-to-angle distance (ATA), anterior chamber width (ACW), and lens vault (LV) were obtained...
November 29, 2017: Japanese Journal of Ophthalmology
Jae Hui Kim, Young Suk Chang, Dong Won Lee, Chul Gu Kim, Jong Woo Kim
PURPOSE: To evaluate changes in the thickness of retinal layers after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, observational study. METHODS: This study included 21 patients (21 eyes) who had been diagnosed with submacular hemorrhage secondary to PCV and treated using anti-vascular endothelial growth factor monotherapy. After the hemorrhage had resolved, the thicknesses of the retinal layers were measured on horizontal- and vertical-crosshair optical coherence tomography scan images...
November 29, 2017: Japanese Journal of Ophthalmology
Fangkun Zhao, Ling Li, Wenkai Zhou, Dong Shi, Yu Fan, Liwei Ma
PURPOSE: To explore the correlation between ocular cyclotorsion induced by sitting and supine positions as well as other selected factors, validated by an image-guided system. STUDY DESIGN: A cross-sectional study conducted in 73 inpatients (85 eyes) who received intraocular operations in China Medical University. METHODS: The ocular cyclotorsion degree was recorded using an image-guided system (Verion Reference Unit, Alcon) by comparing images captured in sitting position, as well as pre- and post-different anesthesia methods in the supine position...
November 13, 2017: Japanese Journal of Ophthalmology
Mari Takahashi, Tadashi Yokoi, Satoshi Katagiri, Tomoyo Yoshida-Uemura, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To describe the clinical features and surgical outcomes of macular dragging or tractional retinal detachment that occurred as a result of fibrovascular tissue (FT) progression toward the posterior retina in eyes with familial exudative vitreoretinopathy (FEVR). METHODS: The medical records of 4 patients (2 girls, 2 boys) with FEVR were reviewed retrospectively. RESULTS: All 4 patients had retinal dragging or radial retinal folds with FT in the peripheral retina in at least 1 eye at the initial visit...
November 3, 2017: Japanese Journal of Ophthalmology
Tomoyuki Inoue, Toshihiko Uno, Norio Usui, Shinichiro Kobayakawa, Kiyoshi Ichihara, Yuichi Ohashi
PURPOSE: To prospectively survey the incidence of endophthalmitis following cataract surgery and investigate the current perioperative practices in Japan. METHODS: Patients who underwent cataract surgery from January 2012 to December 2013 were included. Information on perioperative practices were recorded prospectively. Clinical characteristics were examined in cases with endophthalmitis. RESULTS: A total of 63,244 patients who underwent cataract surgery in 205 facilities were enrolled...
November 1, 2017: Japanese Journal of Ophthalmology
Hiroyuki Iijima
PURPOSE: To study the reduction in light sensitivity in areas where impaired retinal perfusion was established by fluorescein angiogram (FA) in eyes with branch retinal vein occlusion (BRVO) that recovered from retinal edema and hemorrhage. DESIGN: Retrospective observational case series. METHODS: A study of the reduction in light sensitivity demonstrated by total deviation display of the Humphrey perimetry program 30-2 in 43 eyes from 42 patients with BRVO, whose perfusion status was assessed by FA images taken at least 6 months after disease onset...
November 1, 2017: Japanese Journal of Ophthalmology
Sakari Nakamine, Hiroshi Sakai, Yoshikuni Arakaki, Michiko Yonahara, Tadayoshi Kaiya
PURPOSE: To study the effect of the internal fixation lamp on anterior chamber width measured by anterior segment optical coherence tomography. METHODS: In a prospective cross sectional observational study, consecutive 22 right eyes of 22 patients (4 men and 18 women) with suspected primary angle closure underwent swept source domain anterior segment optical coherence tomography (AS-OCT), (CASIA SS-1000, Tomey, Nagoya, Japan). Anterior chamber parameters of angle opening distance (AOD), trabecular-iris angle (TIA), angle recess area (ARA) at 500 or 750 µm from scleral spur and pupil diameter were measured by AS-OCT in a three-dimensional mode in 4 quadrants (superior, inferior, temporal and nasal) in dark room setting both with and without internal fixation lamp...
November 1, 2017: Japanese Journal of Ophthalmology
Akira Iwatake, Akira Murakami, Nobuyuki Ebihara
PURPOSE: Sterile ulceration is frequently observed in the cornea following persistent corneal epithelial damage. We examined the effect of alarmins released by necrotic corneal epithelial cells (HCE) on the production of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by corneal fibroblasts. METHODS: IL-1α and high-mobility group box 1 protein (HMGB1) released into the supernatant derived from necrotic HCE cells were measured with enzyme-linked immunosorbent assay (ELISA)...
November 1, 2017: Japanese Journal of Ophthalmology
Reiji Yokota, Akito Hirakata, Nobutsugu Hayashi, Kazunari Hirota, Tosho Rii, Yuji Itoh, Tadashi Orihara, Makoto Inoue
PURPOSE: To evaluate the ultrastructure of the internal limiting membranes (ILMs) excised during vitrectomy from highly myopic eyes with myopic traction maculopathy (MTM). The clinical findings before and after the vitrectomy were compared. METHODS: Seven eyes of 7 patients with macular retinoschisis were studied. Four of these eyes also had a foveal detachment but without a retinal break. All the eyes underwent vitrectomy with the creation of a posterior vitreous detachment and ILM peeling...
October 25, 2017: Japanese Journal of Ophthalmology
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