journal
https://read.qxmd.com/read/21035490/p53-and-regulation-of-bioactive-sphingolipids
#21
REVIEW
Linda A Heffernan-Stroud, Lina M Obeid
Both the sphingolipid and p53 pathways are important regulators- and apparent collaborators-of cell-fate decisions. Whereas some investigations have suggested that ceramide and more complex sphingolipids function upstream of p53 or in a p53-independent manner, other studies propose that p53-dependent alterations in these sphingolipids can also contribute to apoptosis. Further studies focusing on sphingolipid metabolizing enzymes have revealed that they function similarly both upstream and downstream of p53 activation...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035489/capitalizing-on-tumor-genotyping-towards-the-design-of-mutation-specific-inhibitors-of-phosphoinsitide-3-kinase
#22
REVIEW
Sandra B Gabelli, Krisna C Duong-Ly, Evan T Brower, L Mario Amzel
PI3Ks catalyze the phosphorylation of the inositol hydroxyls of phosphoinositide membrane components. The changes in phosphorylation of the inositides recruit proteins to the plasma membrane that initiate important signaling cascades. PI3Kα, one of the class IA PI3Ks, is highly mutated in cancers. All mutations analyzed result in an increase in enzymatic activity. The structures of this enzyme determined by X-ray diffraction, provide a framework for analyzing the possible structural effect of these mutations and their effect on the enzymatic activity...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035488/physiology-and-pathology-of-nuclear-phospholipase-c-%C3%AE-1
#23
REVIEW
Lucio Cocco, Matilde Y Follo, Irene Faenza, Roberta Fiume, Giulia Ramazzotti, George Weber, Alberto M Martelli, Francesco A Manzoli
The existence and function of inositide signaling in the nucleus is well documented and we know that the existence of the inositide cycle inside the nucleus has a biological role. An autonomous lipid-dependent signaling system, independently regulated from its plasma membrane counterpart, acts in the nucleus and modulates cell cycle progression and differentiation.We and others focused on PLCβ1, which is the most extensively investigated PLC isoform in the nuclear compartment. PLCβ1 is a key player in the regulation of nuclear inositol lipid signaling, and, as discussed above, its function could also be involved in nuclear structure because it hydrolyses PtdIns(4,5)P2, a well accepted regulator of chromatin remodelling...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035487/phospholipase-c%C3%AE-3-is-a-novel-binding-partner-of-myosin-vi-and-functions-as-anchoring-of-myosin-vi-on-plasma-membrane
#24
JOURNAL ARTICLE
Kazuyuki Sakurai, Masayuki Hirata, Hideki Yamaguchi, Yoshikazu Nakamura, Kiyoko Fukami
Phospholipase Cδ3 (PLCδ3) is a key enzyme in phosphoinositide metabolism, however, its physiological function remains unknown. Here we identified the Myosin VI (Myo6) as a binding partner of the PLCδ3. A tail region containing IQ motif and the cargo-binding domain of Myo6, and the C2 domain and PH domain of PLCδ3 were responsible sites for the interaction. Since Myo6 has been well analyzed as one of the "deafness genes" in mouse and human, we examined the expression pattern of PLCδ3 mRNA in the inner ear...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035486/subtype-specific-roles-of-phospholipase-c-%C3%AE-via-differential-interactions-with-pdz-domain-proteins
#25
REVIEW
Jung Kuk Kim, Seyoung Lim, Jinho Kim, Sanguk Kim, Jae Ho Kim, Sung Ho Ryu, Pann-Ghill Suh
Since we first identified the PLC-β isozyme, enormous studies have been conducted to investigate the functional roles of this protein (Min et al., 1993; Suh et al.,1988). It is now well-known that the four PLC-β subtypes are major effector molecules in GPCR-mediated signaling, especially for intracellular Ca2+ signaling. Nonetheless, it is still poorly understood why multiple PLC-β subtype exist. Most cells express multiple subtypes of PLC-β in different combinations, and each subtype is involved in somewhat different signaling pathways...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035485/the-neutral-sphingomyelinase-family-identifying-biochemical-connections
#26
REVIEW
Christopher J Clarke, Bill X Wu, Yusuf A Hannun
Neutral sphingomyelinases (N-SMases) are considered to be key mediators of stress-induced ceramide production. The extended family of N-SMases is a subset of the DNaseI superfamily and comprises members from bacteria, yeast and mammals. In recent years, the identification and cloning of mammalian N-SMase family members has led to significant advances in understanding their physiological roles and regulation. However, there is still limited information on their regulation at the biochemical and molecular level...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035484/targeting-the-cancer-initiating-cell-the-achilles-heel-of-cancer
#27
JOURNAL ARTICLE
James A McCubrey, William H Chappell, Stephen L Abrams, Richard A Franklin, Jacquelyn M Long, Jennifer A Sattler, C Ruth Kempf, Piotr Laidler, Linda S Steelman
We have isolated cell with the cancer initiating cell (CIC) phenotype from PC3 cells. The PC3/(CIC) cells are more resistant than the PC3/(BC) cells to chemotherapeutic drugs such as docetaxel which is used to treat prostate cancer. Thus these prostate CICs could lay dormant and persist even after chemotherapeutic drug treatment. Then when the chemotherapeutic drug is removed, they could potentially repopulate the original tumor site or metastize to a distant site. However, the prostate CICs were not significantly more resistant to drugs which target EGFR, NF-κB, Smo and the natural product genistein...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035483/signalling-via-class-ia-pi3ks
#28
REVIEW
Len Stephens, Phill Hawkins
No abstract text is available yet for this article.
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/21035482/muscular-laminopathies-role-of-prelamin-a-in-early-steps-of-muscle-differentiation
#29
JOURNAL ARTICLE
Nadir M Maraldi, Cristina Capanni, Rosalba Del Coco, Stefano Squarzoni, Marta Columbaro, Elisabetta Mattioli, Giovanna Lattanzi, Francesco A Manzoli
Lamin A is a nuclear envelope constituent involved in a group of human disorders, collectively referred to as laminopathies, which include Emery-Dreifuss muscular dystrophy. Because increasing evidence suggests a role of lamin A precursor in nuclear functions, we investigated the processing of prelamin A along muscle differentiation. Both protein levels and cellular localization of prelamin A appears to be modulated during C2C12 mouse myoblasts activation. Similar changes also occur in the expression of two lamin A-binding proteins: emerin and LAP2α...
2011: Advances in Enzyme Regulation
https://read.qxmd.com/read/20045433/identification-of-substrates-for-cyclin-dependent-kinases
#30
REVIEW
Alessia Errico, Krupa Deshmukh, Yoshimi Tanaka, Andrei Pozniakovsky, Tim Hunt
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/20006638/roles-of-inositol-phosphates-and-inositol-pyrophosphates-in-development-cell-signaling-and-nuclear-processes
#31
REVIEW
Marco M Tsui, John D York
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/20005892/structural-basis-for-h3k4-trimethylation-by-yeast-set1-compass
#32
REVIEW
Yoh-Hei Takahashi, Ali Shilatifard
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/20005891/sphingolipid-metabolism-in-trans-golgi-endosomal-membranes-and-the-regulation-of-intracellular-homeostatic-processes-in-eukaryotic-cells
#33
REVIEW
Carl J Mousley, Kyle D Trettin, Kimberly Tyeryar, Kristina E Ile, Gabriel Schaaf, Vytas A Bankaitis
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19948183/protein-kinase-c-alpha-negatively-regulates-egf-induced-plc-epsilon-activity-through-direct-phosphorylation
#34
JOURNAL ARTICLE
Sanguk Yun, Ha-Young Byun, Young-Seok Oh, Yong Ryoul Yang, Sung Ho Ryu, Pann-Ghill Suh
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19948182/the-architecture-of-functional-neighborhoods-within-the-mammalian-cell-nucleus
#35
REVIEW
Kishore S Malyavantham, Sambit Bhattacharya, Ronald Berezney
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19917303/laminopathies-and-a-type-lamin-associated-signalling-pathways
#36
REVIEW
Nadir M Maraldi, Giovanna Lattanzi, Vittoria Cenni, Alberto Bavelloni, Sandra Marmiroli, Francesco A Manzoli
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19914280/development-of-approaches-for-systematic-analysis-of-protein-networks-in-stem-cells
#37
JOURNAL ARTICLE
Andrew J K Williamson, Anthony D Whetton
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19914279/characterization-of-cellular-dgk-theta
#38
JOURNAL ARTICLE
Becky Tu-Sekine, Daniel M Raben
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19914278/protein-kinase-c-a-family-of-protein-kinases-allosteric-effectors-or-both
#39
REVIEW
Angus J M Cameron, Peter J Parker
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
https://read.qxmd.com/read/19914277/zebrafish-inositol-polyphosphate-kinases-new-effectors-of-cilia-and-developmental-signaling
#40
REVIEW
Bhaskarjyoti Sarmah, Susan R Wente
No abstract text is available yet for this article.
2010: Advances in Enzyme Regulation
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