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Hospital Pharmacy

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https://www.readbyqxmd.com/read/28515513/hospital-participation-in-prescription-drug-monitoring-programs
#1
Brent I Fox, Bill G Felkey
The prescription drug abuse epidemic continues to grow. This multifaceted problem requires a multifaceted solution. In this installment, we discuss prescription drug monitoring programs and their relevance to hospital pharmacies.
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515512/a-just-culture-approach-to-managing-medication-errors
#2
Erin Rogers, Emily Griffin, William Carnie, Joseph Melucci, Robert J Weber
Medication errors continue to be a concern of health care providers and the public, in particular how to prevent harm from medication mistakes. Many health care workers are afraid to report errors for fear of retribution including the loss of professional licensure and even imprisonment. Most health care workers are silent, instead of admitting their mistake and discussing it openly with peers. This can result in further patient harm if the system causing the mistake is not identified and fixed; thus self-denial may have a negative impact on patient care outcomes...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515511/approvals-submission-and-important-labeling-changes-for-us-marketed-pharmaceuticals
#3
(no author information available yet)
This monthly feature will help readers keep current on new drug, new indications, dosage forms and safety-related changes in labeling or use. Efforts have been made to assure the accuracy of this information; however, if there are any questions, please let us know at jgeneral@ku.edu.
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515510/eteplirsen
#4
Danial E Baker
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515509/anti-nuclear-cytoplasmic-antibody-associated-vasculitis-a-probable-adverse-effect-of-sofosbuvir-treatment-in-chronic-hepatitis-c-patients
#5
Youssef K Ahmad, Salwa Tawfeek, Mohamed Sharaf-Eldin, Hassan E Elbatea, Abdelrahman Kobtan, Ferial El-Kalla, Rehab Badawi, Sherief Abd-Elsalam
Background: Egypt has the largest hepatitis C virus (HCV) epidemic worldwide. Sofosbuvir is an antiviral drug acting by inhibition of the HCV NS5B polymerase. It has shown high efficacy in combination with several other drugs and has a low reported rate of side effects. Objective: The aim of this prospective cohort study was to assess the safety of sofosbuvir-based treatment regimens used to treat chronic hepatitis C infections and to detect any side effects of sofosbuvir not previously reported. Methods: We studied treatment side effects in 3,000 patients with chronic HCV infection treated with sofosbuvir and ribavirin for 24 weeks or treated by pegylated interferon, sofosbuvir, and ribavirin triple therapy for 12 weeks...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515508/evaluating-sterility-of-single-dose-vials-on-an-automated-compounding-device
#6
Hannah M Hutchinson, Brian E Sayre, Terrence Prettyman, Erica King
Background: Current guidelines for sterile compounding require that single dose vials of pharmaceuticals must be discarded after 6 hours when accessed in an ISO Class 5 environment. At this time, no studies have evaluated the sterility of single dose vials at any time after opening. Objective: The purpose of this study is to evaluate the sterility of single dose vials attached to an automated compounding device for up to 24 hours and accessed and maintained within a cleanroom environment. Methods: This is a prospective, observational study evaluating the sterility of 32 pooled samples of manufactured single dose injectable drugs attached to an automated compounding device for up to 24 hours and maintained within an ISO Class 5 environment in an ISO Class 7 buffer area...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515507/implementing-a-tech-check-tech-program-at-a-university-health-system
#7
Scott A Tarver, Javier Palacios, Reed Hall, A Crystal Franco-Martinez
Background: Tech-Check-Tech (TCT) allows a pharmacy technician to perform the final check of medications prepared by another technician. The effect of a TCT program on the time required to process medications in a hospital pharmacy has not been previously reported. Objective: To evaluate the effect of implementing a TCT program on the time required to prepare, check, and deliver medications to automated medication supply systems (AMSS) located throughout an academic medical center. Methods: The primary outcome was the difference in mean total time required to process AMSS medications between pre- and post-implementation periods...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515506/impact-of-pharmacy-practice-model-expansion-on-pharmacokinetic-services-optimization-of-vancomycin-dosing-and-improved-patient-safety
#8
Zhe Han, Natasha N Pettit, Emily M Landon, Benjamin D Brielmaier
Background: The impact of pharmacy interventions on optimizing vancomycin therapy has been described, however interventions vary among studies and the most optimal pharmacy practice model (PPM) for pharmacokinetic (PK) services has not been established. Objective: The purpose of this study is to demonstrate the value of 24 hours a day, 7 days a week (24/7) PK services. Methods: New PK services were implemented in 2 phases with institutional PPM expansion. Phase 1 included universal monitoring by pharmacists with recommendations made to prescribers during business hours...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515505/application-of-the-layered-learning-practice-model-in-an-academic-medical-center
#9
Brittany M Loy, Sendra Yang, Jason M Moss, Debra W Kemp, Jamie N Brown
The layered learning practice model (LLPM) is a teaching strategy designed to train residents to precept students and other residents with the oversight of a seasoned clinical pharmacist. This model serves as a tool for residency programs to implement quality precepting opportunities and learning experiences as they look for new ways to integrate multiple learners into the practice setting. The levels of the LLPM include a senior preceptor, resident, and student. It is best implemented through utilization of 4 steps: orientation to the LLPM, preexperience planning, implementation, and postexperience evaluation...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515504/21st-century-cures-act
#10
Michael Gabay
No abstract text is available yet for this article.
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515503/drug-monographs-olaratumab-and-rucaparib
#11
Dominic A Solimando, J Aubrey Waddell
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr, President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, e-mail: OncRxSvc@comcast...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515502/ismp-adverse-drug-reactions-pregabalin-induced-stuttering-nitroglycerine-induced-bradycardia-progressing-to-asystole-minocycline-induced-dress-leading-to-liver-transplantation-and-type-1-diabetes-increased-risk-of-vertebral-fractures-in-women-receiving-thiazide
#12
Michael A Mancano
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Mancano at ISMP, 200 Lakeside Drive, Suite 200, Horsham, PA 19044 (phone: 215-707-4936; e-mail: mmancano@temple.edu). Your report will be published anonymously unless otherwise requested...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515501/ismp-medication-error-report-analysis-potential-issues-with-new-basal-insulin-glp-1-fixed-combinations-hydroxyzine-hydroxyurea-mix-up-concomitant-use-of-entresto-and-ace-inhibitors-can-lead-to-serious-outcomes-more-outpatient-oral-cancer-drugs-should-be-in
#13
Michael R Cohen, Judy L Smetzer
These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515500/comment-on-probable-tapentadol-associated-serotonin-syndrome-after-overdose
#14
Marc Russo, Danielle Santarelli, Geoff Isbister
No abstract text is available yet for this article.
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515499/comment-on-tapentadol-and-serotonin-syndrome
#15
Michael E Mullins, William H Dribben
No abstract text is available yet for this article.
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28515498/using-lean-to-develop-frontline-clinical-staff-pharmacists-as-residency-program-primary-preceptors
#16
EDITORIAL
Leah Frantzen, Brandon Ordway
No abstract text is available yet for this article.
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28439140/are-pharmacists-participating-in-postdischarge-patient-reminders
#17
Bill G Felkey, Brent I Fox
In this column, we are making a short revisit to the technology that can assist in satisfaction of Meaningful Use criteria and can assist health systems that are increasing their population health initiatives to help improve outcomes while containing costs.
March 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28439139/approvals-submission-and-important-labeling-changes-for-us-marketed-pharmaceuticals
#18
(no author information available yet)
This monthly feature will help readers keep current on new drug, new indications, dosage forms and safety-related changes in labeling or use. Efforts have been made to assure the accuracy of this information; however, if there are any questions, please let us know at jgeneral@ku.edu.
March 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28439138/bezlotoxumab
#19
Danial E Baker
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers...
March 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28439137/compatibility-of-ceftazidime-avibactam-ceftolozane-tazobactam-and-piperacillin-tazobactam-with-vancomycin-in-dextrose-5-in-water
#20
Kevin Meyer, Maressa Santarossa, Larry H Danziger, Eric Wenzler
Objectives: The compatibility of vancomycin with existing and novel β-lactam/β-lactamase inhibitors at clinically relevant concentrations in 5% dextrose in water has not been fully explored to date. Methods: Vancomycin concentrations tested ranged from 5 to 20 mg/mL. Ceftazidime-avibactam was tested at 8, 20, and 40 mg/mL, ceftolozane-tazobactam at 15 mg/mL, and piperacillin-tazobactam at 28 mg/mL. Compatibility of drug admixtures were tested via both simulated and actual y-site infusion. For the simulated y-site compatibility assessment, 1:1 mixtures of each respective drug were analyzed over 24 hours...
March 2017: Hospital Pharmacy
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