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Hospital Pharmacy

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https://www.readbyqxmd.com/read/29581608/physical-compatibility-of-micafungin-with-sodium-bicarbonate-hydration-fluids-commonly-used-with-high-dose-methotrexate-chemotherapy
#1
Logan C Joiner, Clay Tynes, John Arnold, Rachel R Miller, Greg Gorman
Purpose: The purpose of this study was to determine the physical compatibility of micafungin with commonly used concentrations of sodium bicarbonate hydration fluids administered via a Y-site connected to a central venous catheter (Y-site/CVC). Methods: Micafungin sodium (evaluated concentration of 1.5 mg/mL) was combined in a 3:1 (vehicle:drug) ratio with the following commonly used hydration vehicles: 40 mEq/L sodium bicarbonate in 5% dextrose in water with ¼ normal saline (40SB-D5W-1/4NS), 75 mEq/L sodium bicarbonate in D5W (75SB-D5W), and 154 mEq/L sodium bicarbonate in D5W (154SB-D5W)...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581607/incidence-of-hypoglycemia-in-burn-patients-a-focus-for-process-improvement
#2
David M Hill, Sean Lloyd, William L Hickerson
Background: Glycemic control in burn patients is critical for reducing infection and mortality. Objective: This study was conducted to assess the incidence and outcomes of hypoglycemia during continuous insulin infusions (CII). Methods: This institutional review board-approved study was a retrospective, single burn center, electronic chart review. Patients admitted between January 1, 2013, and October 31, 2014, who received a CII were included. Patients with incomplete data or who received <24 hours of CII were excluded...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581606/changes-in-pharmacy-residency-training-design-between-2012-and-2017-a-perspective-of-academic-medical-centers
#3
Anne Krasniak, William Darko, Christopher D Miller, Robert Seabury, Luke A Probst
Purpose: The role of health-system pharmacists continues to expand, and this area of pharmacy practice increasingly requires augmented baseline training. It is unclear how Post Graduate Year 1 (PGY-1) pharmacy residencies may be changing to meet these needs.The objectives of our survey were to describe PGY-1 pharmacy residency program design among academic medical centers, characterize program changes enacted over 5-year period, and describe career paths among PGY-1 pharmacy residency graduates. Methods: A 32-item questionnaire was developed independently, which was reviewed and validated by 4 residency program directors...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581605/antihypertensive-prescription-pattern-and-compliance-to-jnc-7-and-jnc-8-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-study
#4
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Dinesh Kumar Bharatraj
Background: The monitoring of hypertension treatment can provide insight into the rational drug use pattern. The objective of this study was to examine the antihypertensive medication use among South Indian adults with hypertension in compliance with the hypertension treatment guidelines (Seventh Joint National Committee [JNC 7] and JNC 8). Methods and Results: A total of 550 hypertensive people aged >25 years were included in this retrospective cross-sectional study. The order of drugs prescribed in the year 2012 was beta blockers (BB) > calcium channel blockers (CCB) > CCB + BB > angiotensin receptor blockers (ARB) > angiotensin-converting enzyme inhibitors (ACEI) > thiazide diuretics, whereas in the year 2014, the order has changed drastically, namely, ACEI > CCB > ARB > BB > thiazide diuretics ( P < ...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581604/breadth-of-statistical-training-among-pharmacy-residency-programs-across-the-united-states
#5
Cheyenne Newsome, Keenan Ryan, Ludmila Bakhireva, Preeyaporn Sarangarm
Background: Pharmacy residents' knowledge of biostatistics is a self-identified deficit. Objective: To describe statistical training practices across postgraduate year 1 (PGY1) pharmacy residency programs and correlate training practices with residency program directors' (RPDs) confidence in their residents' statistical abilities. Methods: A 13-item survey was sent to PGY1 RPDs and included questions regarding respondents' institution, program characteristics, type and amount of statistical training offered and desired, as well as performance of statistics, resident project publication rates, and RPDs' confidence in residents' statistical abilities...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581603/development-and-implementation-of-a-combined-master-of-science-and-pgy1-pgy2-health-system-pharmacy-administration-residency-program-at-a-large-community-teaching-hospital
#6
Nicholas P Gazda, Emily Griffin, Kasey Hamrick, Jordan Baskett, Meghan M Mellon, Stephen F Eckel, Robert P Granko
Purpose: The purpose of this article is to share experiences after the development of a health-system pharmacy administration residency with a MS degree and express the need for additional programs in nonacademic medical center health-system settings. Summary: Experiences with the development and implementation of a health-system pharmacy administration residency at a large community teaching hospital are described. Resident candidates benefit from collaborations with other health-systems through master's degree programs and visibility to leaders at your health-system...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581602/ismp-adverse-drug-reactions-minocycline-induced-drug-fever-without-skin-rash-lupus-erythematosus-like-eruption-induced-by-hydroxyurea-cardiotoxicity-and-fever-induced-by-clozapine-denosumab-induced-hepatotoxicity-severe-cardiotoxicity-induced-by-bevacizumab
#7
https://www.readbyqxmd.com/read/29581601/ismp-medication-error-report-analysis
#8
Michael R Cohen
No abstract text is available yet for this article.
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581600/the-prescription-drug-user-fee-act-cause-for-concern
#9
Michael Gabay
The Prescription Drug User Fee Act (PDUFA) was originally enacted into law in 1992. PDUFA provides the Food and Drug Administration (FDA) with needed revenue in the form of various fees paid by drug and biologic manufacturers. The FDA utilizes this revenue to streamline the review and approval process for medications. Since the enactment of PDUFA, the median approval time for priority new drug applications and biologics license applications has reduced significantly. The FDA views PDUFA as a successful program that provides a consistent revenue stream to the agency, improves access to medications for patients, and allows industry to have a more predictable product review timeline...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581599/new-medications-in-the-treatment-of-acute-decompensated-heart-failure
#10
Ryan Dahn, Scot Walker
Acute decompensated heart failure is a sudden worsening of heart failure symptoms, typically resulting in peripheral edema and dyspnea as a result of pulmonary congestion. Acute decompensated heart failure is responsible for over 1 million hospitalizations every year. Current pharmacologic therapy is limited in its options. Despite an improved survival rate, statistic still suggests that about 50% of patients die within 5 years of diagnosis. New pharmacologic agents aim to improve efficacy by targeting previously unexplored physiological pathways...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581598/formulary-drug-reviews-glecaprevir-pibrentasvir
#11
Terri L Levien, Danial E Baker
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581597/stability-of-2-mg-ml-adenosine-solution-in-polyvinyl-chloride-and-polyolefin-infusion-bags
#12
Michael DeAngelis, Alexander Ferrara, Kaleigh Gregory, Kimberly Zammit, Fang Zhao
Adenosine is a potent endogenous mediator of vasodilation. Compounded sterile solutions of adenosine are used in cardiac catheterization lab to perform stress tests on the heart. These tests are used to determine the fractional flow reserve (FFR) and are commonly used in the management and diagnosis of cardiovascular conditions. The purpose of this study was to assess the physical and chemical stability of 2 mg/mL adenosine in 0.9% Sodium Chloride Injection, USP in polyvinyl chloride [PVC]) and polyolefin infusion bags stored at room temperature (20°C-25°C) and under refrigeration (2°C-8°C)...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29581596/why-is-burnout-a-taboo
#13
EDITORIAL
Samm Anderegg
No abstract text is available yet for this article.
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29436525/corrigendum
#14
(no author information available yet)
[This corrects the article DOI: 10.1177/0018578717720507.].
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29434389/outcomes-from-a-pharmacist-led-proton-pump-inhibitor-stewardship-program-at-a-single-institution
#15
Rebekah A Wahking, Randal L Steele, Rachel E Hanners, Sean M Lockwood, Kelly W Davis
Background: Proton pump inhibitors (PPIs) are effective medications for acid-related disorders; however, they are also overused and may be associated with several adverse effects. A PPI stewardship program was implemented at one institution to combat the overuse of PPIs. Objective: The purpose of this study is to evaluate the effectiveness of an inpatient PPI stewardship program in reducing PPI use, both during hospitalization and upon discharge. Methods: This was a retrospective cohort study of all patients admitted to an internal medicine service at a single institution from March 14, 2016, to August 14, 2016, with an intervention by the PPI stewardship team...
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29434388/acute-hepatocellular-jaundice-after-dofetilide-initiation-a-case-report
#16
Patrick Gary Rose, Robert Seabury, Gregory Cwikla
Dofetilide's hepatotoxicity is not well described. In this case report, we describe acute hepatocellular jaundice related to dofetilide use in a 33-year-old male being treated for atrial fibrillation. Both viral and ischemic causes of hepatocellular damage were ruled out as unlikely in this case. This case report outlines a rare yet probable report of idiosyncratic dofetilide-induced liver injury.
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29434387/antimicrobial-utilization-pattern-in-pediatric-patients-in-tertiary-care-hospital-eastern-ethiopia-the-need-for-antimicrobial-stewardship
#17
Samuel Girma, Mekonnen Sisay, Getnet Mengistu, Firehiwot Amare, Dumessa Edessa
Background: Antimicrobials are among the most frequently prescribed medications for pediatric patients. However, inappropriate use of them can increase morbidity, mortality, healthcare costs, and largely antimicrobial resistance. This study aims to assess the antimicrobial utilization pattern in the pediatric ward of Hiwot Fana Specialized University Hospital. Methods: Retrospective cross-sectional study was conducted to assess the antimicrobial utilization. In this study, 403 pediatric medical records selected by systematic random sampling were reviewed...
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29434386/evaluation-of-the-incidence-of-ibuprofen-administration-in-alcohol-and-opioid-detoxification-patients-with-concomitant-thrombocytopenia
#18
Sheheryar Muhammad, John R Tomko, Laura M Wilson
Purpose: The purpose of this study was to determine the incidence of ibuprofen administration in patients who are undergoing alcohol and opioid detoxification, and have concomitant alcohol-related thrombocytopenia. Methods: This was a single-center, cross-sectional, prospective, observational study. A daily manual review of electronic health records was conducted for patients admitted to the detoxification unit of the hospital. Patients who (1) were of age 18 years or more, (2) were ordered both alcohol and opioid detoxification protocols, and (3) had a platelet count of less than 150 000/µL were included in the study...
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29434385/antibiotics-in-development-for-the-treatment-of-resistant-bacterial-disease
#19
Ryan Kidd, Scot Walker
Many bacterial infections can be treated with the use of antibiotics. These medications continue to reduce morbidity and mortality; unfortunately, their use has brought about drug-resistant pathogens that produce difficult-to-treat infections, which require more extreme treatments. New antibiotics are needed to combat this ever-evolving resistance pathogenesis.
February 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29434384/formulary-drug-review-betrixaban
#20
REVIEW
Danial E Baker
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers...
February 2018: Hospital Pharmacy
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