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International Journal of Cancer. Journal International du Cancer

Manolis Kogevinas, Ana Espinosa, Adela Castelló, Inés Gómez-Acebo, Marcela Guevara, Vicente Martin, Pilar Amiano, Juan Alguacil, Rosana Peiro, Victor Moreno, Laura Costas, Guillermo Fernández-Tardón, Jose Juan Jimenez, Rafael Marcos-Gragera, Beatriz Perez-Gomez, Javier Llorca, Conchi Moreno-Iribas, Tania Fernández-Villa, Madalen Oribe, Nuria Aragones, Kyriaki Papantoniou, Marina Pollán, Gemma Castano-Vinyals, Dora Romaguera
Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morning or evening activity. We conducted a population-based case-control study in Spain, 2008-2013. In this analysis we included 621 cases of prostate and 1,205 of breast cancer and 872 male and 1,321 female population controls who had never worked night shift...
July 17, 2018: International Journal of Cancer. Journal International du Cancer
Susanne Hofmann, Michael Schmitt, Marlies Götz, Hartmut Döhner, Markus Wiesneth, Donald Bunjes, Jochen Greiner
T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusions (DLI) due to graft-versus-leukemia effect. For better characterization of the T cell responses, we assessed frequency and diversity of leukemia-associated antigen (LAA)-specific cytotoxic T cells using ELISpot and pMHC multimer assays and analyzed the frequency of regulatory T cells (Treg) as well as cytokine profiles before/after DLI...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Susanna Hegewisch-Becker, Ali Aldaoud, Thomas Wolf, Beate Krammer-Steiner, Hartmut Linde, Renate Scheiner-Sparna, David Hamm, Martina Jänicke, Norbert Marschner
Pancreatic cancer is a highly lethal malignancy. Developments in recent years have broadened our therapeutic armamentarium. Novel drugs such as nab-paclitaxel, liposomal irinotecan and chemotherapy regimens such as FOLFIRINOX have been successfully tested in clinical trials. Data on patients outside of clinical trials are scarce but necessary to assess and improve the standard of care. We present data on treatment and survival of 1,174 patients with locally advanced, inoperable or metastatic pancreatic ductal adenocarcinoma...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Wei Wang, Chenglin Yang, Haibo Nie, Xiaofu Qiu, Lianbo Zhang, Yuansong Xiao, Wuer Zhou, Qinsong Zeng, Xiaoming Zhang, Yigao Wu, Jun Liu, Min Ying
LIM kinases modulate multiple aspects of cancer development, including cell proliferation and survival. As the mechanisms of LIMK-associated tumorigenesis are still unclear, we analyzed the tumorigenic functions of LIM kinase 2 (LIMK2) in human bladder cancer (BC) and explored whether the newly identified LIMK2 3'-UTR SNP rs2073859 (G-to-A allele) is correlated with clinical features. Expression levels of LIMK2 in 38 human BC tissues and 8 cell lines were examined using quantitative real-time PCR and immunohistochemistry...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Partha Basu, Farida Selmouni, Latifa Belakhel, Catherine Sauvaget, Loubna Abousselham, Eric Lucas, Richard Muwonge, Rengaswamy Sankaranarayanan, Youssef Chami Khazraji
Breast Cancer Screening Program was introduced and rolled out in Morocco in 2010. Women between 40 and 69 years are screened at the primary health centers (PHC) with clinical breast examination (CBE). A comprehensive evaluation of the program was conducted in 2016-2017 for quality assurance and mid-term course correction. The evaluation process involved: in-depth interviews of program managers; focus group discussions with service-providers of screening, diagnosis and treatment; supportive supervisory visits to randomly selected PHCs and diagnostic centers; desk review of the national guidelines and other published documents; and analysis of the performance data compiled by the program-in-charge...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Roshni Roy, Raju Kandimalla, Fuminori Sonohara, Masahiko Koike, Yasuhiro Kodera, Naoki Takahashi, Yasuhide Yamada, Ajay Goel
Treatment modalities in esophageal squamous cell carcinoma (ESCC) depend largely on lymph node metastasis (LNM) status. With sub-optimal detection sensitivity of existing imaging techniques, we propose a methylation signature which identifies patients with LNM with greater accuracy. This would allow precise stratification of high-risk patients requiring more aggressive treatment from low-risk ESCC patients who can forego radical surgery. An unbiased genome-wide methylation signature for LNM detection was established from an initial in-silico discovery phase...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Kiki C Andree, Anouk Mentink, Leonie L Zeune, Leon W M M Terstappen, Nikolas H Stoecklein, Rui P Neves, Christiane Driemel, Rita Lampignano, Liwen Yang, Hans Neubauer, Tanja Fehm, Johannes C Fischer, Elisabetta Rossi, Mariangela Manicone, Umberto Basso, Piero Marson, Rita Zamarchi, Yohann Loriot, Valerie Lapierre, Vincent Faugeroux, Marianne Oulhen, Françoise Farace, Gemma Fowler, Mariane Sousa Fontes, Berni Ebbs, Maryou Lambros, Mateus Crespo, Penny Flohr, Johann S de Bono
Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a 'liquid biopsy'. In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen liters of blood. Here we present the results obtained from 34 metastatic cancer patients subjected to DLA in the participating institutions. 7.5 mL blood processed with CellSearch was used as 'gold standard' reference...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Hsiang-Ju Chen, Rui-Lan Huang, Phui-Ly Liew, Po-Hsuan Su, Lin-Yu Chen, Yu-Chun Weng, Cheng-Chang Chang, Yu-Chi Wang, Michael Wing-Yan Chan, Hung-Cheng Lai
Ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy. Prevailing evidences suggest that drug resistance and recurrence of ovarian HGSC are caused by the presence of cancer stem cells. Therefore, targeting cancer stems is appealing, however, all attempts to date, have failed. To circumvent this limit, we analyzed differential transcriptomes at early differentiation of ovarian HGSC stem cells and identified the developmental transcription factor GATA3 as highly expressed in stem, compared to progenitor cells...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Babatunde Akinwunmi, Allison F Vitonis, Linda Titus, Kathryn L Terry, Daniel W Cramer
Statins are widely used to lower blood cholesterol and reduce risk for cardiovascular diseases, but attention has recently focused on a role in cancer prevention or therapy. Here we present data from a large case-control study addressing whether statin use can lower the risk for epithelial ovarian cancer (EOC). Between 1992 and 2008, data including medications used for at least six months were collected from 2040 cases with EOC and 2100 frequency-matched controls without the disease who participated in the New England Case Control study...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Isaac Nardi, Theresa Reno, Xinwei Yun, Terra Sztain, Jami Wang, Huifang Dai, Li Zheng, Jae Kim, Dan Raz
In the last decade, it has become clear that epigenetic changes act together with genetic mutations to promote virtually every stage of tumorigenesis and cancer progression. This knowledge has triggered searches for "epigenetic drugs" that can be developed into new cancer therapies. Here we report that triptolide reduced lung cancer incidence from 70% to 10% in a Fen1 E160D transgenic mouse model and effectively inhibited cancer growth and metastasis in A549 and H460 mouse xenografts. We found that triptolide induced lung cancer cell apoptosis that was associated with global epigenetic changes to histone 3 (H3)...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Tess V Clendenen, Joanne Dorgan, Anne Zeleniuch-Jacquotte
No abstract text is available yet for this article.
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Erqi L Pollom, Yushen Qian, Alexander L Chin, Frederick M Dirbas, Steven M Asch, Allison W Kurian, Kathleen C Horst, C Jillian Tsai
Neoadjuvant chemotherapy is used to allow more limited breast surgery without compromising local control. We sought to evaluate nationwide surgical trends in patients with operable breast cancer treated with neoadjuvant chemotherapy and factors associated with surgical type. We used the National Cancer Database to identify 235,339 women with unilateral T1-3N0-3M0 breast cancer diagnosed between 2010 and 2014, and treated with surgery and chemotherapy. Of these, 59,568 patients (25.3%) were treated with neoadjuvant chemotherapy...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Hongyong Song, Beibei Sun, Yueling Liao, Dongliang Xu, Wenzheng Guo, Tong Wang, Bo Jing, Min Hu, Kaimi Li, Feng Yao, Jiong Deng
GPRC5A, a retinoic acid induced gene, is preferentially expressed in lung tissue. Gprc5a gene deletion leads to spontaneous lung tumor development. However, the mechanism of Gprc5a-mediated lung tumor suppression is not fully understood. Here we showed that MDM2, a p53 negative regulator, was dysregulated in Gprc5a-knockout (ko) mouse tracheal epithelial cells (KO-MTEC) compared to wild type (WT) ones. Targeting MDM2 in 1601, a Gprc5a-ko mouse derived lung tumor cell line, and A549, human lung cancer cells, by MDM2 inhibitor Nutlin-3a or small hairpin RNA (sh-RNA), restored p53 signaling pathway, reduced cancer stem cell markers and inhibited tumorigenicity...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
A K Roseweir, C Y Kong, J H Park, Lindsay Bennett, A G M T Powell, J Quinn, H C van Wyk, P G Horgan, D C McMillan, Joanne Edwards, C S Roxburgh
It is increasingly appreciated that host factors within the tumor centre and microenvironment play a key role in dictating colorectal cancer (CRC) outcomes. As a result, the metastatic process has now been defined as a result of epithelial-mesenchymal transition (EMT). Establishment of the role of EMT within the tumor centre and its effect on the tumor microenvironment would be beneficial for prognosis and therapeutic intervention in CRC. The present study assessed five immunohistochemical EMT markers within the tumor centre on a 185 stage II/III CRC patient TMA...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Zhongnan Yin, Chunxiao Li, Junjie Wang, Lixiang Xue
Cancer progression is closely related to the tumor microenvironment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, signaling molecules and the extracellular matrix. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can impact the growth and evolution of cancerous cells. One of major cell components in the tumor microenvironment is myeloid-derived suppressor cells (MDSCs) which promote tumor growth and metastasis directly or indirectly by recognizing other immune cells, producing cytokines and exerting their immunosuppression functions...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Daphne L van der Velden, Julia M Houthuijzen, Jeanine M L Roodhart, Erik van Werkhoven, Emile E Voest
Mesenchymal stem cells (MSCs) can play a vital role in tumor progression and anti-cancer therapy response, as demonstrated by various in vitro and in vivo model systems. Their ability to home to developing tumors and modulate the tumor microenvironment, by suppressing T-cell responses and contributing to the tumor stroma, is suggested to have a significant impact on disease progression, metastasis formation and therapy response. Most evidence, however, is derived from artificial models using exogenously administered MSCs...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Mano Wakamatsu, Yumi Sugawara, Shu Zhang, Fumiya Tanji, Yasutake Tomata, Ichiro Tsuji
It is unclear whether weight change during adulthood affects the risk of obesity-related cancers such as those of the esophagus, colorectum, pancreas, breast, endometrium, and kidney among Japanese, where obesity is less frequent and less severe. We examined the association between weight change during adulthood and the risk of obesity-related cancer among Japanese by conducting a pooled analysis of two prospective studies of residents in Miyagi Prefecture, Japan. A total of 78,743 persons (40,422 women and 38,321 men) aged 40-79 years participated in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
ShaoMing Wang, Neal D Freedman, Erikka Loftfield, Xing Hua, Christian C Abnet
The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We prospectively investigated the associations of alcohol consumption with gastric cardia adenocarcinoma (GCA) and gastric non-cardia adenocarcinoma (GNCA) in 490,605 adults, aged 50-71 years at baseline who participated in the NIH-AARP Diet and Health Study...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Maria Rosaria Esposito, Andrea Binatti, Marcella Pantile, Alessandro Coppe, Katia Mazzocco, Luca Longo, Mario Capasso, Vito Alessandro Lasorsa, Roberto Luksch, Stefania Bortoluzzi, Gian Paolo Tonini
Neuroblastoma (NB) is an embryonic malignancy of the sympathetic nervous system with heterogeneous biological, morphological, genetic and clinical characteristics. Although genomic studies revealed the specific biological features of NB pathogenesis useful for new therapeutic approaches, the improvement of high-risk (HR)-NB patients overall survival is still unsatisfactory. To further clarify the biological basis of disease aggressiveness, we used whole exome sequencing to examine the genomic landscape of HR-NB patients at stage M with short survival (SS) and long survival (LS)...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
Hans Tesch, Oliver Stoetzer, Thomas Decker, Christian M Kurbacher, Frederik Marmé, Andreas Schneeweiss, Christoph Mundhenke, Andrea Distelrath, Peter A Fasching, Michael P Lux, Diana Lüftner, Hadji Peyman, Wolfgang Janni, Mathias Muth, Julia Kreuzeder, Claudia Quiering, Florin-Andrei Taran
In BOLERO-2, adding everolimus to exemestane resulted in a twofold increase in median progression-free survival (PFS) vs exemestane in postmenopausal women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (aBC) after progression on a non-steroidal aromatase inhibitor (NSAI). Here, we report on the open-label, single-arm, phase IIIB 4EVER trial (NCT01626222). This trial evaluated the clinical effectiveness of everolimus plus exemestane in postmenopausal women with HR+, HER2- aBC who had progressed on or after an NSAI, but with no restrictions on the time of progression after NSAI, prior chemotherapy for advanced disease, or previous exemestane...
July 11, 2018: International Journal of Cancer. Journal International du Cancer
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