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International Journal of Cancer. Journal International du Cancer

Qiqi Wang, Ran Song, Chunjuan Zhao, Hua Liu, Ying Yang, Siyu Gu, Duiping Feng, Junqi He
HPV16 is the predominant type of HPV causing invasive cervical cancer. However, the underlying molecular mechanism of the unparalleled carcinogenic power of HPV16 compared with other types of High-risk (HR)-HPV including HPV18 is still elusive. The PDZ binding motif (PBM) of high-risk HPV E6 plays an important role in neoplasia and progression of cervical cancer. HPV16 E6 rather than HPV18 E6, interacted with NHERF1 by its PBM region, and induced degradation of NHERF1. NHERF1 retarded the assembly of cytoskeleton by downregulation of ACTN4, thereby inhibited the migration and invasion of cervical cancer cells in both cell and mouse model...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Yunjian Pan, Chongze Yuan, Chao Cheng, Yiliang Zhang, Yuan Ma, Difan Zheng, Shanbo Zheng, Yuan Li, Yan Jin, Yihua Sun, Haiquan Chen
NF1 is a tumor suppressor gene that negatively regulates Ras signaling. NF1 deficiency plays an important role in carcinogenesis. To investigate the frequency and clinical significance of NF1 mutation, we examined mutation status of NF1, TP53, LKB1 and RB1 in 704 surgically resected lung adenocarcinomas from East Asian patients using semiconductor-based Ion Torrent sequencing platform. Common driver events, including mutations in EGFR, KRAS, HER2, BRAF, MET, and fusions affecting ALK, RET and ROS1, were also concurrently detected...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Mark P Purdue, Qing Lan, Judith Hoffman-Bolton, Allan Hildesheim, Catherine L Callahan, Paul Strickland, Kala Visvanathan, Nathaniel Rothman
Elevated serum sCD27 and sCD30 from a single banked sample have been associated with future non-Hodgkin lymphoma risk; however, the etiologic relevance of this finding is unclear. To address this question, we conducted a case-control study (235 cases, 235 controls) nested within the CLUE-I and CLUE-II cohorts, which enrolled participants in 1974 and 1989 respectively in Washington County, Maryland. Our study features a subset of 102 cases and 102 controls with two banked pre-diagnostic samples each, collected fifteen years apart...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Irina Alimova, Angela Pierce, Etienne Danis, Andrew Donson, Diane K Birks, Andrea Griesinger, Nicholas K Foreman, Mariarita Santi, Laura Soucek, Sujatha Venkataraman, Rajeev Vibhakar
Loss of SMARCB1 is the hallmark genetic event that characterizes rhabdoid tumors in children. Rhabdoid tumors of the brain (ATRT) occur in young children and are particularly challenging with poor long term survival. SMARCB1 is a member of the SWI/SNF chromatin remodeling complex that is responsible for determining cellular pluripotency and lineage commitment. The mechanisms by which SMARCB1 deletion results in tumorigenesis remain unclear. Recent studies demonstrate that ATRT consists of 3 genomic sub-groups with a subset of poor outcome tumors expressing high BMP and MYC pathway activation...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Maya Schulpen, Petra H Peeters, Piet A van den Brandt
Studies investigating the association of Mediterranean diet (MD) adherence with pancreatic cancer risk are limited and had inconsistent results. We examined the association between MD adherence and pancreatic cancer incidence by pooling data from the Netherlands Cohort Study (NLCS, 120852 subjects) and the Dutch cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-NL, 40011 subjects). MD adherence was assessed using alternate and modified Mediterranean diet scores (aMED and mMED, respectively), including and excluding alcohol...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Yingcheng Wu, Jinhuan Wei, Xia Chen, Yongwei Qin, Renfang Mao, Jian Song, Yihui Fan
Aging is the single most significant risk factor for cancer development. However, the potential impact of aging on cancer microenvironment remains poorly understood. Here, we performed a pan-cancer transcriptome analysis to identify aging-specific molecular patterns across 18 cancer types. Strikingly, aging-specific molecular features define human cancers into two types, including the strong and weak aging-effect groups. Significant aging associated molecular signature was observed in 16 cancer types (strong aging-effect group) such as breast invasive carcinoma and acute myeloid leukemia...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Bingqing Hu, Haidi Hu, Mingzhu Yin, Zhengrong Sun, Xiaoya Chen, Ying Li, Ziyi Sun, Cong Liu, Ling Li, Yang Qiu
Androgen receptor (AR) signaling is involved in the initiation and progression of prostate cancer (PCa), which is the most frequently diagnosed non-skin cancer and remains a leading cause of cancer-related death in men. Further investigation of the involvement of AR signaling in PCa progression is urgently needed. In the present study, we performed a yeast two-hybrid screen and demonstrated that SERTA domain-containing protein 1 (Sertad1) is a novel AR-binding protein that binds to the AR ligand binding domain (LBD)...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Juliane Daßler-Plenker, Annette Paschen, Bastian Putschli, Stephanie Rattay, Saskia Schmitz, Marion Goldeck, Eva Bartok, Gunther Hartmann, Christoph Coch
Activation of the innate immune receptor retinoic acid-inducible gene I (RIG-I) by its specific ligand 5'-triphosphate RNA (3pRNA) triggers anti-tumor immunity, which is dependent on natural killer (NK) cell activation and cytokine induction. However, to date, RIG-I expression and the functional consequences of RIG-I activation in NK cells have not been examined. Here, we show for the first time the expression of RIG-I in human NK cells and their activation upon RIG-I ligand (3pRNA) transfection. 3pRNA-activated NK cells killed melanoma cells more efficiently than NK cells activated by type I interferon...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Paulina Gomez-Rubio, Janet Piñero, Esther Molina-Montes, Alba Gutiérrez-Sacristán, Mirari Marquez, Marta Rava, Christoph W Michalski, Antoni Farré, Xavier Molero, Matthias Löhr, José Perea, William Greenhalf, Michael O'Rorke, Adonina Tardón, Thomas Gress, Victor M Barberà, Tatjana Crnogorac-Jurcevic, Luís Muñoz-Bellvís, Enrique Domínguez-Muñoz, Joaquim Balsells, Eithne Costello, Jingru Yu, Mar Iglesias, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Josefina Mora, Liam Murray, Damian O'Driscoll, Ignasi Poves, Rita T Lawlor, Weimin Ye, Manuel Hidalgo, Aldo Scarpa, Linda Sharp, Alfredo Carrato, Francisco X Real, Laura I Furlong, Núria Malats
Deciphering the underlying genetic basis behind pancreatic cancer PC and its associated multimorbidities will enhance our knowledge towards PC control. The study investigated the common genetic background of PC and different morbidities through a computational approach and further evaluated the less explored association between PC and autoimmune diseases AIDs through an epidemiological analysis. Gene-disease associations GDAs of 26 morbidities of interest and PC were obtained using the DisGeNET public discovery platform...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Yoojin Noh, Sang-Min Jeon, Sooyoung Shin
Preclinical data suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors may promote metastatic progression of preexisting cancer via nuclear factor erythroid 2 related factor 2 (NRF2) activation. We aimed to investigate the association between different glucose-lowering treatments, including DPP-4 inhibitors and metformin, both with potential NRF2 modulating effects, and new-onset metastatic cancer among type 2 diabetes patients with comorbid incident cancer. This population-based cohort study included 223,530 diabetic patients newly diagnosed with primary cancer during 2009-2011 in Korea...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
David Fiedler, Kerstin Heselmeyer-Haddad, Daniela Hirsch, Leanora S Hernandez, Irianna Torres, Darawalee Wangsa, Yue Hu, Luis Zapata, Josef Rueschoff, Sebastian Belle, Thomas Ried, Timo Gaiser
Colorectal adenomas are common precancerous lesions with the potential for malignant transformation to colorectal adenocarcinoma. Endoscopic polypectomy provides an opportunity for cancer prevention; however, recurrence rates are high. We collected formalin-fixed paraffin-embedded tissue of fifteen primary adenomas with recurrence, fifteen adenomas without recurrence, and fourteen matched pair samples (primary adenoma and the corresponding recurrent adenoma). The samples were analysed by array-comparative genomic hybridisation (aCGH) and single-cell multiplex-interphase fluorescence in situ hybridisation (miFISH) to understand clonal evolution, to examine the dynamics of copy number alterations (CNAs) and to identify molecular markers for recurrence prediction...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
Ganji Purnachandra Nagaraju, Leah Benton, Shipra Reddy Bethi, Mamoru Shoji, Bassel F El-Rayes
Curcumin is a polyphenolic constituent of turmeric that is known to have various molecular effects in preclinical models, leading to prevention and anti-cancer properties. In clinical trials, curcumin has failed to demonstrate activity against pancreatic cancer possibly due to its low bioavailability and potency. Using the curcumin molecular model, our group and others have synthesized several analogs with better bioavailability and higher potency in pancreatic cancer in vitro and xenograft models. This mini review summarizes some of the known molecular effects of curcumin analogs and their potential role as novel therapeutics for pancreatic cancer...
September 18, 2018: International Journal of Cancer. Journal International du Cancer
Li Wang, Hongying Zhao, Yingqi Xu, Jing Li, Chunyu Deng, Yulan Deng, Jing Bai, Xia Li, Yun Xiao, Yunpeng Zhang
Copy number alterations (CNAs) of lincRNAs act as one of important mechanisms in disrupting lincRNA expression which may play critical roles during tumorigenesis in lung adenocarcinoma (LUAD). The copy number alterations of lincRNAs can mark the spectrum of cancer progression and may serve as biomarkers for prognosis in LUAD, however it is rarely studied. We analyzed RNASeq data for 488 LUAD patients from TCGA portal and 58 healthy subjects to identify prognostic lincRNAs predictive of patient survival. Computational analysis entailing integration of expression and copy number alteration data revealed five prognostic lincRNAs: RBPMS-AS1, TDRKH-AS1, LINC00578, RP11-470M17...
September 18, 2018: International Journal of Cancer. Journal International du Cancer
Susmita Mondal, Debarshi Roy, Sayantani Sarkar Bhattacharya, Ling Jin, Deokbeom Jung, Song Zhang, Eleftheria Kalogera, Julie Staub, Yaxian Wang, Wen Xuyang, Ashwani Khurana, Jeremey Chien, Sucheta Telang, Jason Chesney, Gilles Tapolsky, Dzeja Petras, Viji Shridhar
Metabolic alterations are increasingly recognized as important novel anti-cancer targets. Amongst several regulators of metabolic alterations, fructose 2,6 bisphosphate (F2,6BP) is a critical glycolytic regulator. Inhibition of the active form of PFKFB3ser461 using a novel inhibitor, PFK158 resulted in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. Moreover, we found that PFK158 synergizes with carboplatin (CBPt) and paclitaxel (PTX) in the chemoresistant cell lines, C13 and HeyA8MDR but not in their chemosensitive counterparts, OV2008 and HeyA8, respectively...
September 18, 2018: International Journal of Cancer. Journal International du Cancer
Sun Ah Ham, Eunsu Kim, Taesik Yoo, Won Jin Lee, Ju Ho Youn, Mi-Jung Choi, Sung Gu Han, Chi-Ho Lee, Kyung Shin Paek, Jung Seok Hwang, Han Geuk Seo
Peroxisome proliferator-activated receptor (PPAR) δ is a promising therapeutic target in metabolic and inflammatory disorders. However, its role in oncogenesis is controversial, and its therapeutic potential remains to be determined. In the present study, we show that ligand-activated PPARδ forms a complex with the proto-oncogene product c-Myc. The interaction of PPARδ with c-Myc affected the transcriptional activity of c-Myc and the expression of its target genes. The PPARδ-dependent regulation of c-Myc activity was associated with decreased tumorigenicity in breast cancer cells...
September 11, 2018: International Journal of Cancer. Journal International du Cancer
Nader Kim El-Mallawany, Parth S Mehta, William Kamiyango, Jimmy Villiera, Erin C Peckham-Gregory, Coxcilly Kampani, Robert Krysiak, Marcia K Sanders, Carolina Caro-Vegas, Anthony B Eason, Saeed Ahmed, Gordon E Schutze, Stephen C Martin, Peter N Kazembe, Michael E Scheurer, Dirk P Dittmer
Kaposi sarcoma (KS) is among the most common childhood malignancies in central, eastern, and southern Africa. Although its unique clinical features have been established, biological mechanisms related to the causative agent, KS-associated herpesvirus (KSHV), have yet to be explored in children. We performed a prospective observational pilot study to explore associations between KSHV viral load (VL), human interleukin-6 (IL-6) and IL-10 levels, and clinical characteristics of 25 children with KS in Lilongwe, Malawi from June 2013-August 2015...
September 11, 2018: International Journal of Cancer. Journal International du Cancer
Michael Hoffmeister, Bernd Holleczek, Christian Stock, Nadine Zwink, Thomas Stolz, Christa Stegmaier, Hermann Brenner
Previous studies have reported that repeat colonoscopies were often not conducted in the recommended time interval after screening colonoscopy. We prospectively followed participants of screening colonoscopy from Germany for 6 years to investigate utilization and determinants of repeat colonoscopies. In a longitudinal study on the effectiveness of screening colonoscopy in the state of Saarland (Germany), participants who had a screening colonoscopy between 2005 and 2007 were contacted by mail 6 years after screening and requested to fill in a standardized questionnaire on utilization of repeat colonoscopies...
September 11, 2018: International Journal of Cancer. Journal International du Cancer
Carla J Gargallo, Ángel Lanas, Patricia Carrera-Lasfuentes, Ángel Ferrandez, Enrique Quintero, Marta Carrillo, Inmaculada Alonso-Abreu, M A García-Gonzalez
This study aimed to evaluate the relevance of genetic susceptibility in the development of colorectal adenomas (CRA) and its relationship with the presence of family history of colorectal cancer (CRC). Genomic DNA from 750 cases (first degree relatives of patients with CRC) and 750 controls (subjects with no family history of CRC) was genotyped for 99 single nucleotide polymorphisms (SNPs) previously associated with CRC/CRA risk by GWAS and candidate gene studies by using the MassArray™ (Sequenom) platform...
September 8, 2018: International Journal of Cancer. Journal International du Cancer
Christian H Klein, Dina C Truxius, Holger A Vogel, Jana Harizanova, Sandip Murarka, Pablo Martín-Gago, Philippe I H Bastiaens
Ras proteins, most notably KRas, are prevalent oncogenes in human cancer. Plasma membrane localization and thereby signaling of KRas is regulated by the prenyl-binding protein PDEδ. Recently, we have reported the specific anti-proliferative effects of PDEδ inhibition in KRas-dependent human pancreatic ductal adenocarcinoma cell lines. Here, we investigated the proliferative dependence on the solubilizing activity of PDEδ of human colorectal cancer (CRC) cell lines with or without oncogenic KRas mutations...
September 8, 2018: International Journal of Cancer. Journal International du Cancer
Oded Komemi, Gali Epstein Shochet, Meir Pomeranz, Ami Fishman, Metsada Pasmanik-Chor, Liat Drucker, Shelly Tartakover Matalon, Michael Lishner
The extracellular matrix (ECM) affects cancer cell characteristics. Inability of normal epithelial cells to attach to the ECM induces apoptosis (anoikis). Cancer cells are often anoikis resistant, a prerequisite for their metastatic spread. Previously we demonstrated that the placenta manipulates its surrounding ECM in a way that prevents breast cancer cells (BCCL) attachment and induces their motility and aggregation. This fits with the fact that although breast cancer during pregnancy is often advanced, metastasis to the placenta is rarely observed...
September 8, 2018: International Journal of Cancer. Journal International du Cancer
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