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International Journal of Cancer. Journal International du Cancer

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https://www.readbyqxmd.com/read/28801947/how-will-transitioning-from-cytology-to-hpv-testing-change-the-balance-between-the-benefits-and-harms-of-cervical-cancer-screening-estimates-of-the-impact-on-cervical-cancer-treatment-rates-and-adverse-obstetric-outcomes-in-australia-a-high-vaccination-coverage
#1
Louiza S Velentzis, Michael Caruana, Kate T Simms, Jie-Bin Lew, Ju-Fang Shi, Marion Saville, Megan A Smith, Sarah J Lord, Jeffrey Tan, Deborah Bateson, Michael Quinn, Karen Canfell
Primary HPV screening enables earlier diagnosis of cervical lesions compared to cytology, however, its effect on the risk of treatment has not been investigated. We estimated the cumulative lifetime risk (CLR) of cervical cancer and excisional treatment; and change in adverse obstetric outcomes in HPV unvaccinated women and cohorts offered vaccination (>70% coverage in 12-13 years) for the Australian cervical screening program. 2-yearly cytology screening (ages 18-69 years) was compared to 5-yearly primary HPV screening with partial genotyping for HPV16/18 (ages 25-74 years)...
August 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28801942/cancer-risk-in-different-generations-of-middle-eastern-immigrants-to-california-1988-2013
#2
Clara Ziadeh, Argyrios Ziogas, Hoda Anton-Culver
The objective of this study is to compare cancer risk among different generations of Middle Eastern (ME) immigrants and Non-Hispanic Whites (NHW) in California between 1988 and 2013. We used data from the California Cancer Registry to identify invasive primary incident cancer cases in three population groups: a) first generation ME immigrants, b) second or subsequent generations ME immigrants, and c) NHW. Proportional Incidence Ratio (PIR) was used to compare cancer risk of the 15 selected most common cancers in the 3 population groups taking into consideration time since immigration for first generation ME immigrants...
August 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28801919/familial-associations-of-female-breast-cancer-with-other-cancers
#3
Guoqiao Zheng, Hongyao Yu, Akseli Hemminki, Asta Försti, Kristina Sundquist, Kari Hemminki
Familial risks of breast cancer (BC) are well established but whether BC clusters with other, i.e. discordant, cancers is less certain but of interest for the identification of common genetic and possible environmental factors contributing to a general cancer susceptibility. We apply a novel approach to search for familial associations of BC with other (discordant) cancers based on the Swedish Family-Cancer Database. Relative risks (RRs) were calculated for BC in families with increasing numbers of patients with discordant cancer X, and conversely, familial RRs for cancer X in families with increasing numbers of BC patients...
August 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28801914/blockade-of-transforming-growth-factor-%C3%AE-signaling-enhances-oncolytic-herpes-simplex-virus-efficacy-in-patient-derived-recurrent-glioblastoma-models
#4
Shinichi Esaki, Fares Nigim, Esther Moon, Samantha Luk, Juri Kiyokawa, William Curry, Daniel P Cahill, Andrew S Chi, A John Iafrate, Robert L Martuza, Samuel D Rabkin, Hiroaki Wakimoto
Despite the current standard of multimodal management, glioblastoma (GBM) inevitably recurs and effective therapy is not available for recurrent disease. A subset of tumor cells with stem-like properties, termed GBM stem-like cells (GSCs), are considered to play a role in tumor relapse. Although oncolytic herpes simplex virus (oHSV) is a promising therapeutic for GBM, its efficacy against recurrent GBM is incompletely characterized. Transforming growth factor beta (TGF-β) plays vital roles in maintaining GSC stemness and GBM pathogenesis...
August 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28799271/reduced-disease-specific-survival-following-a-diagnosis-of-multiple-primary-cutaneous-malignant-melanomas-a-nationwide-population-based-study
#5
Deborah Utjés, Johan Lyth, Jan Lapins, Hanna Eriksson
Outcome data comparing patients with multiple primary invasive cutaneous malignant melanomas (MPMs) to single primary invasive cutaneous malignant melanoma (SPM) show conflicting results. We have analyzed differences in disease-specific survival between these patients in a nationwide population-based setting. From the Swedish Melanoma Register, 27,235 patients were identified with a first invasive cutaneous malignant melanoma (CMM) between 1990 and 2007, followed-up through 2013. Of these, 700 patients developed MPMs...
August 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28795403/prostate-and-breast-cancer-in-four-nordic-countries-a-comparison-of-incidence-and-mortality-trends-across-countries-and-age-groups-1975-2013
#6
R Kvåle, T A Myklebust, G Engholm, S Heinävaara, E Wist, B Møller
In recent decades, management of prostate and breast cancer patients has changed considerably. The purpose of the present study is to interpret patterns of prostate and breast cancer incidence and mortality in four Nordic countries across age groups and time periods. Prostate and breast cancer incidence and mortality data (1975-2013) were obtained from the NORDCAN database. Joinpoint regression models were used to identify changes in the trends. A more prominent increase in prostate than breast cancer incidence was observed...
August 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28795402/meta-analysis-of-the-association-between-dietary-inflammatory-index-dii-and-cancer-outcomes
#7
Mackenzie E Fowler, Tomi F Akinyemiju
Pro-inflammatory dietary patterns have been associated with increased cancer risk and mortality. We present a systematic review and meta-analysis of the current published literature on a Dietary Inflammatory Index (DII) score and its association with cancer risk and mortality outcomes. Published articles from online databases (PubMed, Scopus, and Embase) examining the association between DII and any cancer risk, incidence, or mortality between 1980 and November 2016 were selected for review. Results of studies meeting inclusion criteria were summarized and meta-analyzed using STATA to generate summary measures of association across studies...
August 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28795393/investigation-of-cross-contamination-among-human-cell-lines-used-in-china
#8
Mingzhen Wang, Meimei Yang, Yuehong Liu, Yaqing Huang, Fang Ye, Congyi Zheng, Chao Shen
Increasing attention has been paid to the hazard of cell line cross-contamination. More journals are requiring that cell lines be authenticated prior to manuscript submission. China Center for Type Culture Collection (CCTCC) has authenticated cell lines for publications in the International Journal of Cancer since 2009. Between 2010 and 2016, we authenticated 485 cell lines from 66 Chinese universities and research institutes. Almost 50% of cell lines were misidentified, most were completely replaced by other cell lines (mainly HeLa and its sublines)...
August 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791697/the-association-of-genetic-variations-in-dna-repair-pathways-with-severe-toxicities-in-nsclc-patients-undergoing-platinum-based-chemotherapy
#9
Yi Zheng, Zheng Deng, Jiye Yin, Shiming Wang, Daru Lu, Xiaoke Wen, Xiangping Li, Di Xiao, Chengping Hu, Xiang Chen, Wei Zhang, Honghao Zhou, Zhaoqian Liu
Genetic variations in genes involved in repairing platinum-induced DNA lesions may contribute to the toxicity of platinum-based chemotherapy. The role of single nucleotide polymorphisms (SNPs) within DNA repair pathways in the occurrence of severe toxicity is not yet understood. Current studies prefer to do original works rather than analyze previously published data. Our study aimed to replicate associations between previously investigated SNPs and toxicities as well as to identify new genetic makers. We systematically examined the relevance of 97 SNPs in 54 candidate genes responsible for repairing DNA inter-strand and intra-strand crosslinks to severe toxicity in a discovery cohort of 437 NSCLC patients receiving platinum-based chemotherapy...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791695/use-of-antidepressants-and-risk-of-epithelial-ovarian-cancer
#10
Lina S Mørch, Christian Dehlendorff, Louise Baandrup, Søren Friis, Susanne K Kjaer
Antidepressants are widely prescribed among women to treat depression and anxiety disorders, but studies of their effects on gynecological cancer risk are sparse. We assessed associations between various antidepressants and risk of epithelial ovarian cancer. By using Danish nationwide registers, we identified all women (cases) aged 30 to 84 years with incident epithelial (serous, endometrioid, clear cell or mucinous) ovarian cancer during 2000-2011 (n= 4,103) and matched each case to 20 population controls (n=58,706) by risk-set matching...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791691/birth-rates-after-radioactive-iodine-treatment-for-differentiated-thyroid-cancer
#11
Chelsea Anderson, Stephanie M Engel, Mark A Weaver, Jose P Zevallos, Hazel B Nichols
Treatment with radioactive iodine (RAI) for differentiated thyroid cancer has been associated with alterations in gonadal function in women, including changes in menstrual function and an earlier age at menopause. Our objective was to evaluate associations between RAI and post-diagnosis live birth rates among thyroid cancer survivors diagnosed at ages 15-39 years. We identified women diagnosed with differentiated thyroid cancer between January 2000 and December 2013 in the North Carolina Central Cancer Registry (CCR)...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791684/sleep-characteristics-light-at-night-and-breast-cancer-risk-in-a-prospective-cohort
#12
Alexandra J White, Clarice R Weinberg, Yong-Moon Park, Aimee A D'Aloisio, Emily Vogtmann, Hazel B Nichols, Dale P Sandler
Increasing numbers of women in the US are getting too little sleep. Inadequate sleep has been associated with impaired metabolic function and endocrine disruption. Sister Study cohort participants (n=50,884), completed baseline and follow-up questionnaires on sleep patterns. Incident breast cancers estrogen receptor (ER) status of the tumor were ascertained from questionnaires and medical records. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses of sleep characteristics reported at the first follow-up interview included only participants who were breast cancer-free at time of follow-up interview...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28791678/circulating-mitochondrial-stress-70-protein-mortalin-and-cytosolic-hsp70-in-blood-risk-indicators-in-colorectal-cancer
#13
Ritta Jubran, Judit Kocsis, Nóra Garam, Éva Maláti, Tímea Gombos, Lóránd Barabás, László Gráf, Zoltán Prohászka, Zvi Fishelson
Mitochondrial mortalin and cytosolic Hsp70 are essential chaperones overexpressed in cancer cells. Our goals were to reproduce our earlier findings of elevated circulating levels of mortalin and Hsp70 in colorectal cancer (CRC) patients with a larger patient cohort, to compare death risk assessment of mortalin, Hsp70, CEA and C19-9 and to assess their prognostic value in various CRC stages. Mortalin, Hsp70, CEA and CA19-9 levels were determined in sera of 235 CRC patients enrolled in the study and followed-up 5 years after surgery...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28786109/prognosis-of-cancer-in-persons-with-infrequent-consultations-in-general-practice-a-population-based-cohort-study
#14
Henry Jensen, Peter Vedsted, Henrik Møller
Cancer survival rates are lower in Denmark than in comparable European countries. This may partly be attributable to subgroups of cancer patients who seek medical attention at late disease stages. It is unknown if differences in usual (i.e. customary) consultation frequency in general practice are associated with cancer prognosis. We aimed to estimate the cancer prognosis of cancer patients stratified by their usual consultation frequency in general practice. We performed a population-based cohort study including 123,943 incident cancer patients aged 50-89 years diagnosed in Denmark in 2009-2013...
August 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28779483/four-pten-targeting-co-expressed-mirnas-and-actn4-targeting-mir-548b-are-independent-prognostic-biomarkers-in-human-squamous-cell-carcinoma-of-the-oral-tongue
#15
Ilyes Berania, Guillaume B Cardin, Isabelle Clément, Louis Guertin, Tareck Ayad, Eric Bissada, Phuc Felix Nguyen-Tan, Edith Filion, Julie Guilmette, Olguta Gologan, Denis Soulieres, Francis Rodier, Philip Wong, Apostolos Christopoulos
The purpose of this study was to determine the prognostic value and oncogenic pathways associated to miRNA expression in squamous cell carcinoma of the oral tongue and to link these miRNA candidates with potential gene targets. We performed a miRNA screening within our institutional cohort (n = 58 patients) and reported five prognostic targets including a cluster of four co-expressed miRNAs (miR-18a, miR-92a, miR-103, and miR-205). Multivariate analysis showed that expression of miR-548b (p = 0.007) and miR-18a (p = 0...
August 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28771722/co-administration-of-a-tumor-penetrating-peptide-improves-the-therapeutic-efficacy-of-paclitaxel-in-a-novel-air-grown-lung-cancer-3d-spheroid-model
#16
Sweta K Gupta, Elisa A Torrico Guzmán, Samantha A Meenach
Three-dimensional (3D) cell culture platforms are increasingly being used in cancer research and drug development since they mimic avascular tumors in vitro. In the present study, we focused on the development of a novel air-grown multicellular spheroid (MCS) model to mimic in vivo tumors for understanding lung cancer biology and improvement in the evaluation of aerosol anticancer therapeutics. 3D MCS were formed using A549 lung adenocarcinoma cells, comprising cellular heterogeneity with respect to different proliferative and metabolic gradients...
August 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28758198/mir-15a-16-deficiency-enhances-anti-tumor-immunity-of-glioma-infiltrating-cd8-t-cells-through-targeting-mtor
#17
Jiao Yang, Ronghua Liu, Yuting Deng, Jiawen Qian, Zhou Lu, Yuedi Wang, Dan Zhang, Feifei Luo, Chu Yiwei
MiR-15a/16, a miRNA cluster located at chromosome 13q14, has been reported to act as an immune regulator in inflammatory disorders besides its aberrant expression in cancers. However, little is known about its regulation in tumor-infiltrating immune cells. In this study, using an orthotropic GL261 mouse glioma model, we found that miR-15a/16 deficiency in host inhibited tumor growth and prolonged mice survival, which might be associated with the accumulation of tumor-infiltrating CD8+ T cells. More importantly, tumor-infiltrating CD8+ T cells without miR-15a/16 showed lower expression of PD-1, Tim-3 and LAG-3, and stronger secretion of IFN-γ, IL-2 and TNF-α than WT tumor-infiltrating CD8+ T cells...
July 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#18
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. 815 incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28748634/timing-of-births-and-oral-contraceptive-use-influences-ovarian-cancer-risk
#19
Anna H Wu, Celeste L Pearce, Alice Lee, Chiuchen Tseng, Anjali Jotwani, Prusha Patel, Malcolm C Pike
Increasing parity and duration of combined oral contraceptive (COC) use provide substantial protection against ovarian carcinoma (cancer). There are limited data on the impact of the age of the births or of COC use on reducing ovarian cancer risk. Here, we examined the effects of age at first and last births and age at use of COCs using data from studies conducted in Los Angeles County, California, USA (1,632 cases, 2,340 controls). After adjusting for the number of births, every 5 years that a first birth was delayed reduced the risk of ovarian cancer by 13% (95% CI 5% - 21%; P = 0...
July 27, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28748555/digitalis-use-and-lung-cancer-risk-by-histological-type-in-men
#20
Wentao Li, Shao-Hua Xie, Lap-Ah Tse, Jesper Lagergren
Lung cancer risk and tumor characteristics differ between sexes. Estrogen has been suggested to counteract lung cancer development. We aimed to test the hypothesis that digitalis use decreases lung cancer risk due to its estrogenic and other anticancer properties in men. This was a nationwide Swedish population-based cohort study between July 1, 2005 and December 31, 2013. Data on the use of digitalis and organic nitrates in all male individuals were derived from the Swedish Prescribed Drug Registry. New lung cancer diagnoses among cohort participants were identified from the Swedish Cancer Registry...
July 27, 2017: International Journal of Cancer. Journal International du Cancer
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