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International Journal of Cancer. Journal International du Cancer

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https://www.readbyqxmd.com/read/28431188/t-cell-receptor-%C3%AE-chain-repertoire-analysis-reveals-the-association-between-neoantigens-and-tumour-infiltrating-lymphocytes-in-multifocal-papillary-thyroid-carcinoma
#1
Zheming Lu, Chaoting Zhang, Jindong Sheng, Jing Shen, Baoguo Liu
To explore whether a few non-synonymous somatic mutations could induce activation and proliferation of neoantigen-specific tumour-infiltrating lymphocytes (TILs) in tumours with low mutation rates, we analysed a patient with multifocal papillary thyroid carcinoma (seven non-contiguous cancer foci) to investigate the relationship between neoantigens and TILs. These seven foci had a few or no non-synonymous somatic mutations; moreover, multiple loci had similar or different spectra of mutations. We used high-throughput sequencing of the rearranged genes in T cell receptor β-chain (TCRβ) to reveal the basic characteristics of T cells in seven tumour foci and matched adjacent normal tissue...
April 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28425625/a-missense-mutation-in-damage-specific-dna-binding-protein-2-is-a-genetic-risk-factor-for-limbal-squamous-cell-carcinoma-in-horses
#2
Rebecca R Bellone, Jiayin Liu, Jessica L Petersen, Maura Mack, Moriel Singer-Berk, Cord Drögemüller, Julia Malvick, Barbara Wallner, Gottfried Brem, M Cecilia Penedo, Mary Lassaline
Squamous cell carcinoma (SCC) is the most common cancer of the equine eye, frequently originating at the limbus, with the potential to invade the cornea, cause visual impairment, and result in loss of the eye. Several breeds of horses have a high occurrence of limbal SCC implicating a genetic basis for limbal SCC predisposition. Pedigree analysis in the Haflinger breed supports a simple recessive mode of inheritance and a genome wide association study (N=23) identified a 1.5 Mb locus on ECA12 significantly associated with limbal SCC (Pcorrected = 0...
April 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28425616/statin-use-and-risk-of-multiple-myeloma-an-analysis-from-the-cancer-research-network
#3
Mara M Epstein, George Divine, Chun R Chao, Karen E Wells, Heather Spencer Feigelson, Delia Scholes, Douglas Roblin, Marianne Ulcickas Yood, Lawrence S Engel, Andrew Taylor, Joan Fortuny, Laurel A Habel, Christine C Johnson
Animal and human data suggest statins may be protective against developing multiple myeloma; however, findings may be biased by the interrelationship with lipid levels. We investigated the association between statin use and risk of multiple myeloma in a large US population, with an emphasis on accounting for this potential bias. We conducted a case-control study nested within 6 US integrated healthcare systems participating in the National Cancer Institute-funded Cancer Research Network. Adults aged ≥40 years who were diagnosed with multiple myeloma from 1998-2008 were identified through cancer registries (N=2532)...
April 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28425092/coffee-consumption-and-the-risk-of-colorectal-cancer-by-anatomical-subsite-in-japan-results-from-the-herpacc-studies
#4
Hiroko Senda Nakagawa, Hidemi Ito, Satoyo Hosono, Isao Oze, Hideo Tanaka, Keitaro Matsuo
Consumption of coffee, a popular beverage worldwide, has been associated with lower colorectal cancer (CRC) risk. Although CRC exhibits different biological characteristics by anatomical subsite, the possibly heterogeneous impact of coffee on CRC by anatomical subsite has remained unclear. Here, we conducted two case-control studies to examine the association between coffee consumption and CRC risk as well as risk by anatomic subsite among Japanese using data from the Hospital-based Epidemiological Research Program at Aichi Cancer Center I and II (HERPACC-I and II)...
April 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28419475/fruit-and-vegetable-intake-and-prostate-cancer-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#5
Aurora Perez-Cornago, Ruth C Travis, Paul N Appleby, Konstantinos K Tsilidis, Anne Tjønneland, Anja Olsen, Kim Overvad, Verena Katzke, Tilman Kühn, Antonia Trichopoulou, Eleni Peppa, Maria Kritikou, Sabina Sieri, Domenico Palli, Carlotta Sacerdote, Rosario Tumino, H Bas Bueno-de-Mesquita, Antonio Agudo, Nerea Larrañaga, Elena Molina-Portillo, Eva Ardanaz, Maria-Dolores Chirlaque, Cristina Lasheras, Pär Stattin, Maria Wennberg, Isabel Drake, Johan Malm, Julie A Schmidt, Kay-Tee Khaw, Marc Gunter, Heinz Freisling, Inge Huybrechts, Dagfinn Aune, Amanda J Cross, Elio Riboli, Timothy J Key
Several dietary factors have been studied in relation to prostate cancer; however, most studies have not reported on subtypes of fruit and vegetables or tumor characteristics, and results obtained so far are inconclusive. This study aimed to examine the prospective association of total and subtypes of fruit and vegetable intake with the incidence of prostate cancer overall, by grade and stage of disease, and prostate cancer death. Lifestyle information for 142,239 men participating in the European Prospective Investigation into Cancer and Nutrition from 8 European countries was collected at baseline...
April 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28419472/hepatic-expression-of-oncogenes-bmi1-and-dkk1-is-up-regulated-in-hepatitis-b-virus-surface-antigen-transgenic-mice-and-can-be-induced-by-treatment-with-hbv-particles-or-lipopolysaccharides-in-vitro
#6
Rui Zhang, Catherine I Real, Chao Liu, Hideo A Baba, Guido Gerken, Mengji Lu, Ruth Broering
Previous studies have shown that hepatocellular carcinoma (HCC) develops more frequently in hepatitis B virus surface antigen (HBsAg)-transgenic mice (Alb/HBs) than in wild-type (WT) mice. However, the mechanism of this HCC model has not been well documented. Toll-like receptor 4 (Tlr4) signaling probably links innate immunity and HCC progression. The current study was designed to investigate the role of innate immunity in hepatocarcinogenesis in Alb/HBs mice. Immunohistochemical analysis of liver specimens from Alb/HBs mice (16 per group) showed that the oncogenes Bmi1 (16/16, 100%) and Dkk1 (13/16, 81...
April 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28411390/statin-use-and-mortality-among-ovarian-cancer-patients-a-population-based-cohort-study
#7
Freija Verdoodt, Merete Kjaer Hansen, Susanne K Kjaer, Anton Pottegård, Søren Friis, Christian Dehlendorff
Statin use has been suggested to improve prognosis in cancer patients, however, for ovarian cancer, the evidence is sparse. From the Danish Cancer Registry, we identified patients aged 30-84 years with a histologically verified first diagnosis of epithelial ovarian cancer between 2000-2013. Data on filled prescriptions, death, and potential confounding factors were obtained from nationwide registers. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals for the association between post-diagnostic statin use and all-cause or cancer-specific mortality...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28411388/adiposity-across-the-adult-life-course-and-incidence-of-primary-liver-cancer-the-nih-aarp-cohort
#8
Baiyu Yang, Jessica L Petrick, Scott P Kelly, Barry I Graubard, Neal D Freedman, Katherine A McGlynn
Obesity relatively late in adulthood has been consistently associated with increased risk of primary liver cancer. However, little is known about the role of early adult adiposity and evolution of adiposity across adulthood in hepatocarcinogenesis. We examined adult body mass index (BMI; kg/m(2) ) in relation to hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) in a large prospective cohort. Weight at ages 18, 35, 50 and at study baseline was retrospectively reported by 303,620 participants...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28411381/pbx3-is-essential-for-leukemia-stem-cell-maintenance-in-mll-rearranged-leukemia
#9
Huidong Guo, Yajing Chu, Le Wang, Xing Chen, Yangpeng Chen, Hui Cheng, Lei Zhang, Yuan Zhou, Feng-Chun Yang, Tao Cheng, Mingjiang Xu, Xiaobing Zhang, Jianfeng Zhou, Weiping Yuan
Interaction of HOXA9/MEIS1/PBX3 is responsible for hematopoietic system transformation in MLL-rearranged (MLL-r) leukemia. Of these genes, HOXA9 has been shown to be critical for leukemia cell survival, while MEIS1 has been identified as an essential regulator for leukemia stem cell (LSC) maintenance. Although significantly high expression of PBX3 was observed in clinical acute myeloid leukemia (AML) samples, the individual role of PBX3 in leukemia development is still largely unknown. In this study, we explored the specific role of PBX3 and its associated regulatory network in leukemia progression...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28411367/serum-25-oh-d-concentration-common-variants-of-the-vdr-gene-and-lung-cancer-occurrence
#10
Tomasz Gromowski, Paulina Gapska, Rodney J Scott, Krzysztof Kąklewski, Wojciech Marciniak, Katarzyna Durda, Marcin Lener, Bohdan Górski, Cezary Cybulski, Grzegorz Sukiennicki, Katarzyna Kaczmarek, Katarzyna Jaworska-Bieniek, Katarzyna Paszkowska-Szczur, Piotr Waloszczyk, Jan Lubiński, Tadeusz Dębniak
The first aim of our study was to examine the association between common variants in VDR [rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI) and rs11568820 (Cdx2)] and lung cancer risk in the Polish population. Genotyping and statistical analysis which included Chi-square test with Yates correction and haplotype frequency analysis were performed on a series of 840 consecutively collected lung cancer patients and 920 healthy controls. The second aim was to evaluate the link between serum 25(OH)D concentration and the number of lung cancers in a subgroup of 200 patients...
April 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28411395/a-longitudinal-study-of-smokeless-tobacco-use-and-mortality-in-the-united-states
#11
David S Timberlake, Dmitriy Nikitin, Norman J Johnson, Sean F Altekruse
Few studies in the United States have examined longitudinally the mortality risks associated with use of smokeless tobacco (SLT). The sample of this study was composed of participants from the National Longitudinal Mortality Study who completed a single Tobacco Use Supplement to the Current Population Survey between the years 1985 and 2011. Using survival methods, SLT use at the baseline survey was examined as a predictor of all-cause mortality and cause-specific mortalities in models that excluded individuals who had ever smoked cigarettes, cigars, or used pipes (final n=349,282)...
April 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28407294/altered-tert-promoter-and-other-genomic-regulatory-elements-occurrence-and-impact
#12
Barbara Heidenreich, Rajiv Kumar
Study of genetic alterations, inherited or acquired, that increase the risk or drive cancers and many other diseases had remained mostly confined to coding sequences of the human genome. Data from genome wide associations studies, development of the Encyclopedia of DNA Elements (ENCODE), and a spurt in detection of driver somatic mutations have shifted focus towards noncoding regions of the human genome. The majority of genetic variants robustly associated with cancers and other syndromes identified through genome wide studies are located within noncoding regulatory regions of the genome...
April 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28401532/gram-positive-pneumonia-augments-non-small-cell-lung-cancer-metastasis-via-host-toll-like-receptor-2-activation
#13
Stephen D Gowing, Simon C Chow, Jonathan J Cools-Lartigue, Crystal B Chen, Sara Najmeh, Henry Y Jiang, France Bourdeau, Annie Beauchamp, Ugo Mancini, Isabelle Angers, Betty Giannias, Jonathan D Spicer, Simon Rousseau, Salman T Qureshi, Lorenzo E Ferri
Surgical resection of early stage non-small cell lung cancer (NSCLC) is necessary for cure. However, rates of post-operative bacterial pneumonias remain high and may confer an increased risk for metastasis. Toll-like receptors (TLRs) mediate the inflammatory cascade by recognizing microbial products at the surface of numerous cell types in the lung; however, little is known about how host TLRs influence NSCLC metastasis. TLR2 recognizes gram-positive bacterial cell wall components activating innate immunity...
April 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28393359/metformin-and-the-incidence-of-viral-associated-cancers-in-patients-with-type-2-diabetes
#14
Blánaid M Hicks, Hui Yin, Liliya Sinyavskaya, Samy Suissa, Laurent Azoulay, Paul Brassard
Limited studies have associated metformin with a reduced risk of viral associated cancers, however these had a number of methodological shortcomings. This study investigated whether the use of metformin is associated with a reduced risk of viral associated cancers in patients with type 2 diabetes. A cohort of 137,754 patients newly-prescribed non-insulin antidiabetic drugs between January 1, 1988 and March 31, 2016 was identified from the UK Clinical Practice Research Datalink and followed until a first-ever diagnosis of a viral associated cancer, death from any cause, end of registration with the practice, or March 31, 2016...
April 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28393357/inflammatory-biomarkers-and-cancer-crp-and-supar-as-markers-of-incident-cancer-in-patients-with-serious-nonspecific-symptoms-and-signs-of-cancer
#15
Line Jee Hartmann Rasmussen, Martin Schultz, Anne Gaardsting, Steen Ladelund, Peter Garred, Kasper Iversen, Jesper Eugen-Olsen, Morten Helms, Kim Peter David, Andreas Kjaer, Anne-Mette Lebech, Gitte Kronborg
In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2 and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC...
April 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28393356/association-of-serum-uric-acid-with-increased-risk-of-cancer-among-hypertensive-chinese
#16
Juan Yang, Yupeng Wang, Qianqian Zhao, Xianglin Zhang, Xiaobin Wang, Xianhui Qin, Rong Zhang, Lin Shen, Xiaodong Jiang, Hua Jiang, Yu Lei, Binyan Wang, Jin Gu, Fan Fan Hou, Yong Huo, Wei Gao, Xiping Xu
Several large prospective studies show an association between serum uric acid (SUA) and cancer, however there is a lack of evidence in China. We aimed to investigate the effects of SUA levels on cancer incidence and mortality in China. This study included 20577 adult hypertensive patients with valid SUA measurements who participated in the China Stroke Primary Prevention Trial where subjects were randomly assigned to receive a double-blind treatment of either 10mg enalapril (n=10286) or 10.8mg enalapril-folic acid (n=10291)...
April 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28390157/discs-large-homolog-5-decreases-formation-and-function-of-invadopodia-in-human-hepatocellular-carcinoma-via-girdin-and-tks5-dlg5-regulates-hcc-invadopodia
#17
Yang Ke, Tianhao Bao, Qixin Zhou, Yan Wang, Jiayun Ge, Bimang Fu, Xuesong Wu, Haoran Tang, Zhitian Shi, Xuefen Lei, Cheng Zhang, Yuqi Tan, Haotian Chen, Zhitang Guo, Lin Wang
Invadopodium formation is a crucial early event of invasion and metastasis of hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying regulation of invadopodia remain elusive. This study aimed to investigate the potential role of discs large homolog 5 (Dlg5) in invadopodium formation and function in HCC. We found that Dlg5 expression was significantly lower in human HCC tissues and cell lines than adjacent non-tumor tissues and liver cells. Lower Dlg5 expression was associated with advanced stages of HCC, and poor overall and disease-free survival of HCC patients...
April 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28390156/association-between-hyperinsulinemia-and-increased-risk-of-cancer-death-in-non-obese-and-obese-people-a-population-based-observational-study
#18
Tetsuro Tsujimoto, Hiroshi Kajio, Takehiro Sugiyama
Obesity, metabolic syndrome, and type 2 diabetes are associated with cancer-related mortality. We assessed whether hyperinsulinemia is a risk factor for cancer death in non-obese people without diabetes. We conducted a prospective cohort study using data from the National Health and Nutrition Examination Survey 1999-2010 and followed up the participants until December 31, 2011. For the primary analysis of cancer mortality, we used Cox proportional hazard models to estimate hazard ratios (HRs) in the participants with hyperinsulinemia and those without...
April 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28388839/critical-depurinating-dna-adducts-estrogen-adducts-in-the-etiology-and-prevention-of-cancer-and-dopamine-adducts-in-the-etiology-and-prevention-of-parkinson-s-disease
#19
REVIEW
Ercole L Cavalieri, Eleanor G Rogan, Muhammad Zahid
Endogenous estrogens become carcinogens when dangerous metabolites, the catechol estrogen quinones, are formed. In particular, the catechol estrogen-3,4-quinones can react with DNA to produce an excess of specific depurinating estrogen-DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating subsequent cancer-initiating mutations. Unbalanced estrogen metabolism yields excessive catechol estrogen-3,4-quinones, increasing formation of depurinating estrogen-DNA adducts and the risk of initiating cancer...
April 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28387927/multimodal-lung-cancer-screening-using-the-italung-biomarker-panel-and-low-dose-computed-tomography-results-of-the-italung-biomarker-study
#20
Francesca Maria Carozzi, Simonetta Bisanzi, Laura Carrozzi, Fabio Falaschi, Andrea Lopes Pegna, Mario Mascalchi, Giulia Picozzi, Marco Peluso, Cristina Sani, Luana Greco, Cristina Ocello, Eugenio Paci
Asymptomatic high-risk subjects, randomized in the intervention arm of the ITALUNG trial (1406 screened for lung cancer), were enrolled for the ITALUNG biomarker study (n = 1356), in which samples of blood and sputum were analysed for plasma DNA quantification (cut off 5ng/ml), loss of heterozygosity and microsatellite instability. The ITALUNG biomarker panel (IBP) was considered positive if at least one of the two biomarkers included in the panel was positive. Subjects with and without lung cancer diagnosis at the end of the screening cycle with LDCT (n = 517) were evaluated...
April 7, 2017: International Journal of Cancer. Journal International du Cancer
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