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Belinda A Henry
No abstract text is available yet for this article.
December 24, 2016: Neuroendocrinology
Mathieu Méquinion, Ophélia Le Thuc, Sara Zgheib, David Alexandre, Nicolas Chartrel, Carole Rovère, Pierre Hardouin, Odile Viltart, Christophe Chauveau
Although short-term effects on fasting or energy deficit on hypothalamic neuropeptide circuitries are now better understood, the effects of long-term energy deficit and refeeding remain to be elucidated. We showed that after a long-term energy deficit mice exhibited persistent hypoleptinemia following the refeeding period despite restoration of fat mass, ovarian activity and feeding behavior. We aimed to examine the hypothalamic adaptations after 10 weeks of energy deficit and after 10 further weeks of nutritional recovery...
December 23, 2016: Neuroendocrinology
Eduardo Spinedi, Daniel P Cardinali, Juan J Gagliardino
No abstract text is available yet for this article.
December 23, 2016: Neuroendocrinology
Wei-Ling Chiu, Jacqueline Boyle, Amanda Vincent, Helena Teede, Lisa J Moran
No abstract text is available yet for this article.
December 23, 2016: Neuroendocrinology
Marta Karpinski, Gabriella Francesca Mattina, Meir Steiner
No abstract text is available yet for this article.
November 28, 2016: Neuroendocrinology
Clemens Reuther, Vera Heinzle, Svenja Nölting, Sabine Herterich, Stefanie Hahner, Ensar Halilovic, Sébastien Jeay, Jens U Wuerthner, Elke Tatjana Aristizabal Prada, Gerald Spöttl, Julian Maurer, Christoph J Auernhammer
No abstract text is available yet for this article.
November 21, 2016: Neuroendocrinology
Yayoi Ikeda, Ayako Tagami, Munekazu Komada, Mifumi Takahashi
No abstract text is available yet for this article.
November 21, 2016: Neuroendocrinology
Kristie Conde, Carolina Fabelo, William C Krause, Robert Propst, Jordan Goethel, Daniel Fischer, Jin Hur, Cecilia Meza, Holly A Ingraham, Edward J Wagner
No abstract text is available yet for this article.
November 21, 2016: Neuroendocrinology
Eleonora S Pagano, Eduardo Spinedi, Juan J Gagliardino
No abstract text is available yet for this article.
November 16, 2016: Neuroendocrinology
Katarina Edfeldt, Kosmas Daskalakis, Christofer Bäcklin, Olov Norlén, Eva Tiensuu Janson, Gunnar Westin, Per Hellman, Peter Stålberg
Small intestinal neuroendocrine tumors (SI-NETs) are amine- and peptide producing neoplasms. Most patients display metastases at the time of diagnosis, they have an unpredictable individual disease course and the tumors are often therapy resistant. Chromogranin A (CgA) and 5-hydroxyindoleacetic acid (5-HIAA) are the clinically most used biomarkers today, but there is a great need for novel diagnostic and prognostic biomarkers and new therapeutic targets. Sixty-nine biomarkers were screened in serum from 23 SI-NET patients and 23 healthy controls using multiplex PLA (proximity ligation assay)...
November 9, 2016: Neuroendocrinology
Claudia Veiga Chang, Ricardo Vieira Araujo, Cinthya Santos Cirqueira, Carolina Maria Gomes Cani, Hamilton Matushita, Valter Angelo Sperling Cescato, Maria Candida Barisson Villares Fragoso, Marcello Delano Bronstein, Maria Claudia Nogueira Zerbini, Berenice Bilharinho Mendonca, Luciani Renata Carvalho
BACKGROUND/AIMS: Although craniopharyngioma (CP) is histologically benign, it is a pituitary tumour that grows rapidly and often recurs. Adamantinomatous CP (ACP) was associated with an activating mutation in β-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP. Stem cells have also been identified in pituitary adenoma. Our aim was to characterize the expression pattern of ABCG2, CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, and SOX9 stem cell markers in human ACP and pituitary adenoma...
2017: Neuroendocrinology
Marianne Pavel, Henning Jann, Vikas Prasad, Ignat Drozdov, Irvin M Modlin, Mark Kidd
BACKGROUND/AIMS: A key issue in gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is early identification and prediction of disease progression. Clinical evaluation and imaging are limited due to the lack of sensitivity and disease indolence. We assessed the NETest as a predictive and prognostic marker of progression in a long-term follow-up study. METHODS: GEP-NETs (n = 34) followed for a median 4 years (2.2-5.4) were evaluated. WHO tumor grade/stage grade 1: n = 17, grade 2: n = 14, grade 3: n = 1 (for 2, no grade was available); 31 (91%) were stage IV...
2017: Neuroendocrinology
Yonggang Gao, Jing-Jing Zhou, Yun Zhu, Therese Kosten, De-Pei Li
INTRODUCTION: Prolonged and repeated stresses cause hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. The corticotrophin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN) are an essential component of the HPA axis. MATERIALS AND METHODS: Chronic unpredictable mild stress (CUMS) was induced in Sprague-Dawley rats. GABA reversal potentials (EGABA) were determined by using gramicidin-perforated recordings in identified PVN-CRH neurons through expressing enhanced green fluorescent protein driven by the CRH promoter...
2017: Neuroendocrinology
Karen R Mifsud, Emily A Saunderson, Helen Spiers, Sylvia D Carter, Alexandra F Trollope, Jonathan Mill, Johannes M H M Reul
BACKGROUND: Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. This work investigates the molecular mechanisms underpinning stress-induced changes in hippocampal GR mRNA levels in vivo. METHODS: Male Wistar rats were killed either under baseline conditions or after forced swim stress (FSS; 15 min in 25°C water)...
2017: Neuroendocrinology
Maitrayee Sahu, Prashanth Anamthathmakula, Abhiram Sahu
BACKGROUND: Insulin action in the hypothalamus plays a critical role in the regulation of energy homeostasis, yet the intracellular signaling mechanisms mediating insulin action are incompletely understood. Although phosphodiesterase 3B (PDE3B) mediates insulin action in the adipose tissue and it is highly expressed in the hypothalamic areas implicated in energy homeostasis, its role, if any, in mediating insulin action in the hypothalamus is unknown. We tested the hypothesis that insulin action in the hypothalamus is mediated by PDE3B...
2017: Neuroendocrinology
René Pschowski, Ulrich-Frank Pape, Gerhard Fusch, Christian Fischer, Henning Jann, Alexander Baur, Ruza Arsenic, Bertram Wiedenmann, Stephan von Haehling, Marianne Pavel, Joerg C Schefold
BACKGROUND/AIMS: Data from a considerable number of malignancies demonstrate that depletion of the essential amino acid tryptophan via induction of the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO) serves as an important tumour escape strategy and is of prognostic importance. Here we investigate the predictive value of the activity of IDO as well as levels of tryptophan and respective downstream catabolites in a large cohort of patients with neuroendocrine neoplasms (NEN)...
2017: Neuroendocrinology
Pedro A Fernandes, Eduardo K Tamura, Letícia D'Argenio-Garcia, Sandra M Muxel, Sanseray da Silveira Cruz-Machado, Marina Marçola, Cláudia E Carvalho-Sousa, Erika Cecon, Zulma S Ferreira, Regina P Markus
BACKGROUND/AIM: The nocturnal production of melatonin by the pineal gland is triggered by sympathetic activation of adrenoceptors and may be modulated by immunological signals. The effect of glucocorticoids on nocturnal melatonin synthesis is controversial; both stimulatory and inhibitory effects have been reported. During pathophysiological processes, an increased sympathetic tonus could result in different patterns of adrenoceptor activation in the pineal gland. Therefore, in this investigation, we evaluated whether the pattern of adrenergic stimulation of the pineal gland drives the direction of the glucocorticoid effect on melatonin production...
2017: Neuroendocrinology
Alessandro Vanoli, Stefano La Rosa, Catherine Klersy, Federica Grillo, Luca Albarello, Frediano Inzani, Roberta Maragliano, Rachele Manca, Ombretta Luinetti, Massimo Milione, Claudio Doglioni, Guido Rindi, Carlo Capella, Enrico Solcia
BACKGROUND: Several types of neuroendocrine neoplasms (NENs) have been described in the duodenal tract, from low-grade tumors (NETs) to high-grade neuroendocrine carcinomas (NECs). A comprehensive analysis of histology, hormonal profile and prognostic parameters of a sufficiently large duodenal NEN series to cover all main kinds of neoplasms is however lacking. METHODS: We collected a retrospective series of 203 duodenal wall and ampullary region NENs, from six specialized endocrine pathology centers...
2017: Neuroendocrinology
Isabel Huguet, Ashley B Grossman, Dermot O'Toole
BACKGROUND: The reviewing and assessment of epidemiological characteristics of neuroendocrine tumours (NETs) remains a challenge. Despite the fact that it is an uncommon family of neoplasms, several worldwide series have revealed an increasing incidence of this rare condition. However, the data are difficult to compare over time due to changes in classification. METHODS: We compared the data related to incidence, prevalence, stage of the disease at diagnosis and survival reported in several series, focusing on the differences and trying to examine some of the probable reasons that may explain the variations in the results between studies...
2017: Neuroendocrinology
Jennifer W Hill, Latrice D Faulkner
No abstract text is available yet for this article.
October 11, 2016: Neuroendocrinology
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