Breanna N Harris, Masha Yavari, Latha Ramalingam, P Logan Mounce, Kaylee Alers Maldonado, Angela C Chavira, Sarah Thomas, Shane Scoggin, Caroline Biltz, Naima Moustaid-Moussa
INTRODUCTION: Alzheimer's disease (AD) alters neurocognitive and emotional function and causes dysregulation of multiple homeostatic processes. The leading AD framework pins amyloid beta plaques and tau tangles as primary drivers of dysfunction. However, many additional variables, including diet, stress, sex, age, and pain tolerance, interact in ways that are not fully understood to impact the onset and progression of AD pathophysiology. We asked: 1) does high-fat diet, compared to low-fat diet, exacerbate AD pathophysiology and behavioral decline? And, 2) can supplementation with eicosapentaenoic (EPA)-enriched fish oil prevent high-fat-diet-induced changes? METHODS: Male and female APPswePSdE9 mice, and their non-transgenic littermates, were randomly assigned to a diet condition (low-fat, high-fat, high-fat with EPA) and followed from 2 to 10 months of age...
February 1, 2024: Neuroendocrinology