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Neuroendocrinology

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https://www.readbyqxmd.com/read/29065413/an-evolutionary-genetic-perspective-of-eating-disorders
#1
David Meyre, Alexandra Mayhew, Marie Pigeyre, Jennifer Couturier
<br>Eating disorders (ED) including anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) affect up to 5% of the population in Western countries. Risk factors for developing an ED include personality traits, family environment, gender, age, ethnicity, and culture. Despite being moderately to highly heritable with estimates ranging from 28 to 83%, no genetic risk factors have been conclusively identified. Our objective was to explore evolutionary theories of EDs to provide a new perspective on research into novel biological mechanisms and genetic causes of EDs...
October 24, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/29065411/gut-microbiota-and-host-metabolism-what-relationship
#2
Gilles Mithieux
A large number of genomic studies have reported associations between the gut microbiota composition and metabolic diseases such as obesity or type 2 diabetes. This led to the widespread idea that a causal relationship could exist between intestinal microbiota and metabolic diseases. At odds with this idea, some compelling studies reported that global changes in microbiota composition have no effect on the host metabolism in obese mice or humans. However, specific bacteria are able to confer host metabolic benefits, such as Akkermansia muciniphila or Prevotella copri, when they are given by gavage in obese mice...
October 24, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28968593/gsk3%C3%AE-%C3%AE-a-novel-therapeutic-target-for-neuroendocrine-tumors
#3
Elke Tatjana Aristizabal Prada, Carla Weis, Michael Orth, Michael Lauseker, Gerald Spoettl, Julian Maurer, Ashley Grossman, Christoph Josef Auernhammer, Svenja Nölting, Patricia Grabowski
<br>Introduction: GSK3α/β is a serine/threonine-kinase that plays a critical role in cancer. AIM(S): In this study, we evaluated the effects of the specific GSK3α/β inhibitor AR-A014418 in vitro to gain novel insights into GSK3α/β signaling in NETs. MATERIALS AND METHODS: Human NET cell lines (BON1, QGP1, H727 and GOT1) were treated with different concentrations of AR-A014418 alone and in combination with lovastatin, everolimus, 5-fluorouracil (5-FU) and γ-irradiation...
October 2, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28926843/the-genetic-basis-of-delayed-puberty
#4
S R Howard, Leo Dunkel
<br>The genetic control of puberty remains an important but mostly unanswered question. Late pubertal timing affects over 2% of adolescents and is associated with adverse health outcomes including short stature, reduced bone mineral density and compromised psychosocial health. Self-limited delayed puberty (DP) is a highly heritable trait, which often segregates in an autosomal dominant pattern; however, its neuroendocrine pathophysiology and genetic regulation remain unclear. Some insights into the genetic mutations that lead to familial DP have come from sequencing genes known to cause GnRH deficiency, most recently via next generation sequencing, and others from large-scale genome wide association studies in the general population...
September 18, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28910819/mechanisms-of-targeting-the-mdm2-p53-foxm1-axis-in-well-differentiated-intestinal-neuroendocrine-tumors
#5
Irina Grass, Franziska Briest, Dagmar Sedding, Markus Möbs, Friederike Christen, Joana Benecke, Karolin Fuchs, Daniel Kaemmerer, Stefanie Mende, Jörg Sänger, Almut Kunze, Christina Geisler, Helma Freitag, Florentine Lewens, Lina Worpenberg, Sara Iwaszkiewicz, Britta Siegmund, Wolfgang Walther, Michael Hummel, Patricia Grabowski
<br>Background/Aims: The tumor suppressor p53 is rarely mutated in gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) but they frequently show a strong expression of p53 negative regulators, rendering these tumors excellent targets for a p53 recovery therapy. Therefore, we analyzed the mechanisms of a p53 recovery therapy on intestinal neuroendocrine tumors in vitro and in vivo. METHODS: By western blot and immunohistochemistry, we found that in GEP-NEN biopsy material overexpression of MDM2 was present in intestinal NEN...
September 14, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28898866/enets-newsletter-summer-2017
#6
(no author information available yet)
No abstract text is available yet for this article.
September 12, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28866668/emerging-roles-of-kisspeptin-in-sexual-and-emotional-brain-processing
#7
Alexander N Comninos, Waljit S Dhillo
<br>The emergence of kisspeptin as a crucial regulator of the hypothalamo-pituitary-gonadal (HPG) axis over the last 14 years has answered many questions as to the control of reproductive hormone secretion from the hypothalamus. More recently the role of kisspeptin outside the HPG axis has received increasing attention in the hope of delineating the pathways linking various sensory and social behaviours to reproduction. These studies, in a range of species from zebrafish to humans, have identified a role for kisspeptin in behavioural networks related to reproduction including olfaction, audition, fear, anxiety, mood and sexual arousal...
August 31, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28848175/role-of-oxytocin-on-prolactin-secretion-during-late-pregnancy
#8
Carlos M Villegas-Gabutti, Gisela Pennacchio, Laura Vivas, Graciela A Jahn, Marta Soaje
<br>Backgrounds/Aims: During late pregnancy, blockade of progesterone action by mifepristone (Mp) treatment induces a dopaminergic tone fall that enables naloxone (NAL) administration to release pituitary PRL. We determined whether oxytocin, that stimulates PRL secretion acting directly on anterior pituitary lactotrophs, mediates the stimulatory action of Mp and NAL on PRL secretion during late pregnancy. METHODS: On day 19 of pregnancy, circulating and pituitary oxytocin and PRL levels were measured by RIA, 10, 20 and 30 min after NAL (given at 17...
August 27, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28848144/over-expression-of-mirna-mir-7-5p-is-a-potential-biomarker-in-neuroendocrine-neoplasia-of-the-small-intestine
#9
Anna E Heverhagen, Nathalie Legrand, Vinona Wagner, Volker Fendrich, Detlef K Bartsch, Emily P Slater
No abstract text is available yet for this article.
August 19, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28817826/the-safety-and-efficacy-of-the-s1-temozolomide-regimen-in-patients-with-metastatic-neuroendocrine-tumors
#10
Jiuda Zhao, Hong Zhao, Yihebali Chi
<br><br>Purpose Both capecitabine alone and capecitabine in combination with temozolomide have activities against neuroendocrine tumors (NETs). However, the role of S-1 in NETs is still unknown. We performed a study to evaluate the safety and efficacy of the S-1 plus temozolomide (STEM) regimen in patients with locally advanced or metastatic NETs. Methods A retrospective review was conducted in 20 patients with locally advanced or metastatic NETs treated with the STEM regimen. Of the patients, 15 (75...
August 17, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28813709/natural-history-of-localized-and-locally-advanced-lung-atypical-carcinoid-after-complete-resection-a-joined-french-italian-multicentric-retrospective-study
#11
Francesca Marciello, Olaf Mercier, Piero Ferolla, Jean-Yves Scoazec, Pier Luigi Filosso, Alain Chapelier, Gianluca Guggino, Roberto Monaco, Franco Grimaldi, Stefano Pizzolitto, Joël Guygay, Bertrand Richard de Latour, Dario Giuffrida, Elisabeth Longchampt, Vincent Thomas de Montpreville, Élie Fadel, Annamaria Colao, David Planchard, Mauro Papotti, Antongiulio Faggiano, Eric Baudin
No abstract text is available yet for this article.
August 17, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28803232/digestive-system-mixed-neuroendocrine-non-neuroendocrine-neoplasms
#12
Louis de Mestier, Jérôme Cros, Cindy Neuzillet, Olivia Hentic, Axel Egal, Nelly Muller, Olivier Bouché, Guillaume Cadiot, Philippe Ruszniewski, Anne Couvelard, Pascal Hammel
Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) are a heterogeneous subgroup of rare neoplasms that represent about a third of all poorly differentiated neuroendocrine carcinomas (PDNEC). MiNEN combine a neuroendocrine component, usually a PDNEC, and a non-neuroendocrine component, generally an adenocarcinoma, both accounting for at least 30% of the neoplasm. MiNEN are classified as high-, intermediate-, or low-grade malignancies depending on the metastatic potential of the tumour components. High-grade malignant component should be considered even if it represents <30% of the tumour...
August 12, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28803235/18f-fdg-uptake-in-well-differentiated-neuroendocrine-tumors-correlates-with-both-ki-67-and-vhl-pathway-inactivation
#13
Margot Bucau, Astrid Laurent-Bellue, Nicolas Poté, Olivia Hentic, Jérôme Cros, Nidaa Mikail, Vinciane Rebours, Philippe Ruszniewski, Rachida Lebtahi, Anne Couvelard
<br>Introduction: 18FDG PET-scanner positivity correlates with poor prognosis in neuroendocrine neoplasms (NEN). Glucose transporter 1 (GLUT1) and carbonic anhydrase 9 (CA9) are markers of agressivity in tumors. Together with pVHL, they are involved in tumor cell metabolism via the hypoxia-inducible factor (HIF) signaling pathway. The aim of this study was to compare, in a series of well-differentiated neuroendocrine tumors (NET), the 18-FDG uptake and expression of proliferation marker Ki-67, GLUT-1, CA9 and pVHL...
August 11, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28797000/new-molecular-biological-and-immunological-agents-inducing-hypophysitis
#14
Anna Angelousi, Eleftherios Chatzellis, Gregory Kaltsas
<br>Hypophysitis is a relatively rare disease that exerts a strong autoimmune component encompassing different aetiologies. Immunomodulatory drugs, such as interferon-α, are known to rarely induce hypophysitis. In recent years a large number of new biological and immunomodulatory agents have been introduced into clinical practice. Although immune suppressing agents used for the treatment of autoimmune disorders only rarely are associated with hypophysitis, it is commonly encountered with immunomodulatory agents used for the treatment of cancer...
August 8, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28772276/the-hypothalamic-preoptic-area-and-body-weight-control
#15
Sangho Yu, Marie François, Clara Huesing, Heike Münzberg
<br>The preoptic area (POA) of the hypothalamus is involved in many physiological and behavioral processes thanks to its inter-connections to many brain areas and ability to respond to diverse humoral factors. One main function of the POA is to manage body temperature homeostasis, e.g. in response to ambient temperature change, which is achieved in part by controlling brown adipose tissue (BAT) thermogenesis. The POA is also importantly involved in modulating food intake in response to temperature change, thus making it relevant for body weight homeostasis and obesity research...
August 2, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28743120/everolimus-in-combination-with-octreotide-lar-in-first-line-setting-for-patients-with-neuroendocrine-tumors-a-5-years-update
#16
Emilio Bajetta, Laura Catena, Sara Pusceddu, Francesca Spada, Claudio Iannacone, Italo Sarno, Giandomenico Di Menna, Lorenzo Dottorini, Anna Maria Marte
No abstract text is available yet for this article.
July 26, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28738393/estrogen-and-environmental-enrichment-differentially-affect-neurogenesis-dendritic-spine-immunolabeling-and-synaptogenesis-in-the-hippocampus-of-young-and-reproductively-senescent-female-rats
#17
Tina Sager, Michael Kashon, Kristine Krajnak
<br>Background: Studies examining the ability of estrogen replacement therapy (ERT) to enhance memory in women, and in animal models, have not produced consistent results. However, studies examining the effects of activity and exposure to novel environments consistently find enhancement of memory. METHODS: An animal model of reproductive aging was used to determine if estradiol (E2) replacement, activity, and/or exposure to an enriched environment could act synergistically to improve memory, and neural correlates of memory...
July 24, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28728155/morphological-and-functional-imaging-for-detecting-and-assessing-the-resectability-of-neuroendocrine-liver-metastases
#18
Maxime Ronot, Ashley K Clift, Richard P Baum, Aviral Singh, Harshad R Kulkarni, Andrea Frilling, Valérie Vilgrain
No abstract text is available yet for this article.
July 21, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28641295/diagnosis-assessment-and-therapeutic-strategy-for-colorectal-mixed-adenoneuroendocrine-carcinoma
#19
Toshiaki Tanaka, Manabu Kaneko, Hiroaki Nozawa, Shigenobu Emoto, Koji Murono, Kensuke Otani, Kazuhito Sasaki, Takeshi Nishikawa, Tomomichi Kiyomatsu, Keisuke Hata, Teppei Morikawa, Kazushige Kawai, Toshiaki Watanabe
No abstract text is available yet for this article.
June 23, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28641291/surgical-management-of-patients-with-neuroendocrine-neoplasms-of-the-appendix-appendectomy-or-more
#20
Nikhil Pawa, Ashley K Clift, Helai Osmani, Panagiotis Drymousis, Andrzej Cichock, Rashpal Flora, Robert Goldin, Dimitrios Patsouras, Alan Baird, Anna Malczewska, James Kinross, Omar Faiz, Anthony Antoniou, Harpreet Wasan, Gregory A Kaltsas, Ara Darzi, Jaroslaw B Cwikla, Andrea Frilling
No abstract text is available yet for this article.
June 23, 2017: Neuroendocrinology
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