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Scientia Pharmaceutica

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https://www.readbyqxmd.com/read/28346396/a-pcr-based-molecular-detection-of-strongyloides-stercoralisin-human-stool-samples-from-tabriz-city-iran
#1
Reza Ghasemikhah, Mohammad Amin Tabatabaiefar, Seyed Ali Shariatzadeh, Abbas Shahbazi, Teymour Hazratian
Strongyloides stercoralis is a nematode causing serious infections in immunocompromised patients. In chronically infected patients, the low parasitic content as well as the resemblance of the larvae to several other species make diagnosis basedonmorphology difficult. In the present study, a PCR-based method targeting the internal transcribed sequence 2 (ITS2) of the rDNA region was examined for the molecular detection of S. stercoralis infection from the stool samples. A total of 1800 patients were included...
March 27, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28333116/effect-of-vernonia-amygdalina-del-leaf-ethanolic-extract-on-intoxicated-male-wistar-rats-liver
#2
Maria Immaculata Iwo, Sergia Louisa Sjahlim, Siti Farah Rahmawati
Vernonia amygdalina has been shown to have antioxidant activity, and is also expected to have hepatoprotective activity. This study was conducted to study the effect of V. amygdalina ethanol extracts on intoxicated rat livers. Fresh leaves were extracted in ethanol, and the hepatoprotective activity was tested on male Wistar rats induced with a combination of isoniazid (INH) and rifampicin. Parameters observed were the activity of the enzyme alanine transferase (ALT), serum albumin levels, liver index, and histopathological of the rat liver...
March 23, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28327509/stability-study-and-a-14-day-oral-dose-toxicity-in-rats-of-plantain-leaf-extract-plantago-lanceolata-l-syrup
#3
Kenza Mansoor, Fadi Qadan, Mathias Schmidt, Eyad Mallah, Wael Abudayyih, Khalid Matalka
Plants have been used since antiquity to treat and prevent diseases. Plantain (Plantago lanceolata L.) is traditionally used for the treatment of the common cold and associated symptoms such as cough. This study was designed to evaluate the oral toxicity of plantain leaf extract-containing syrup. In preparation of the toxicological examination and to ensure the quality of the herbal preparation, analytical methods were developed and validated, and stability testing was performed. Physicochemical and microbial quality, thin layer chromatography patterns and high performance liquid chromatography fingerprints complied with the specifications during the entire period of stability testing...
March 22, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28335544/combination-effect-of-antituberculosis-drugs-and-ethanolic-extract-of-selected-medicinal-plants-against-multi-drug-resistant-mycobacterium-tuberculosis-isolates
#4
Prabasiwi Nur Fauziyah, Elin Yulinah Sukandar, Dhyan Kusuma Ayuningtyas
Adverse drug reaction and resistance to antituberculosis drugs remain the causes of tuberculosis therapeutic failure. This research aimed to find the combination effect of standard antituberculosis drugs with Hibiscus sabdariffa L., Kaempferia galanga L., and Piper crocatum N.E. Br against multi-drug resistant (MDR) Mycobacterium tuberculosis isolates. Two MDR strains (i.e., isoniazid/ethambutol resistant and rifampicin/streptomycin resistant) of M. tuberculosis were inoculated in Löwenstein-Jensen medium containing a combination of standard antituberculosis drugs and ethanolic extracts of H...
March 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28335515/dehydroepiandrosterone-dhea-feeding-protects-liver-steatosis-in-obese-breast-cancer-rat-model
#5
Reza Hakkak, Andrea Bell, Soheila Korourian
Obesity is a major health problem in the US and globally. Obesity is associated with the risk of cardiovascular disease, type 2 diabetes, cancers, hyperlipidemia, and liver steatosis development. Dehydroepiandrosterone (DHEA) is a dietary supplement used as an anti-obesity supplement. Previously, we reported that DHEA feeding protects 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors. The objectives of this study were to investigate the effects of obesity and DHEA feeding on liver steatosis, body weight gain, and serum DHEA, DHEA sulfate (DHEA-S), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding protein-3 (IGFBP-3) levels...
March 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28294964/alginate-based-composite-sponges-as-gastroretentive-carriers-for-curcumin-loaded-self-microemulsifying-drug-delivery-systems
#6
Arpa Petchsomrit, Namfa Sermkaew, Ruedeekorn Wiwattanapatapee
Alginate-based composite sponges were developed as carriers to prolong the gastric retention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems (Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of polymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer, adsorbent (colloidal silicon dioxide), and additional polymers-sodium carboxymethyl cellulose (SCMC), hydroxypropyl methylcellulose (HPMC)-was varied systematically to adjust the drug loading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS...
March 15, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28335408/n-hexane-insoluble-fraction-of-plantago-lanceolata-exerts-anti-inflammatory-activity-in-mice-by-inhibiting-cyclooxygenase-2-and-reducing-chemokines-levels
#7
Nanang Fakhrudin, Eny Dwi Astuti, Rini Sulistyawati, Djoko Santosa, Ratna Susandarini, Arief Nurrochmad, Subagus Wahyuono
Inflammation is involved in the progression of many disorders, such as tumors, arthritis, gastritis, and atherosclerosis. Thus, the development of new agents targeting inflammation is still challenging. Medicinal plants have been used traditionally to treat various diseases including inflammation. A previous study has indicated that dichloromethane extract of P. lanceolata leaves exerts anti-inflammatory activity in an in vitro model. Here, we examined the in vivo anti-inflammatory activities of a n-hexane insoluble fraction of P...
March 13, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28282908/six-month-chronic-toxicity-study-of-tamarind-pulp-tamarindus-indica-l-water-extract
#8
Irene Iskandar, Finna Setiawan, Lucy D N Sasongko, I Ketut Adnyana
Tamarind water extract has been shown to demonstrate an anti-obesity effect. In this research, long-term use of tamarind pulp water extract safety was evaluated. Tamarind pulp was extracted by reflux method, followed by freeze-drying to obtain dry extract. Wistar rats were divided into six groups, with 20 animals of each sex per group. The control group and satellite control group received carboxymethylcellulose sodium (CMC-Na) 0.5% 1 mL/100 g bw (body weight) per day. Treatment groups received tamarind pulp extract at doses of 75, 200, 1000, satellite 1000 mg/kg bw per day for six months...
March 8, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28282874/serum-cystatin-c-as-a-biomarker-in-diffuse-large-b-cell-lymphoma
#9
Nada E Hammouda, Manal A Salah El-Din, Mamdouh M El-Shishtawy, Amal M El-Gayar
Elevated serum levels of cystatin C are found to be related to poor outcome and metastatic potential of some malignant disorders. To evaluate the clinical prominence of serum cystatin C in diffuse large B-cell lymphoma (DLBCL), blood samples were obtained from 58 patients at the time of diagnosis and paired blood samples were obtained from 22 patients at the time of remission. Also, serum cystatin C level was measured in matched healthy controls. Serum cystatin C levels were significantly more elevated in DLBCL patients than in controls (p < 0...
March 8, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28264440/anticancer-dose-adjustment-for-patients-with-renal-and-hepatic-dysfunction-from-scientific-evidence-to-clinical-application
#10
Tomi Hendrayana, André Wilmer, Verena Kurth, Ingo Gh Schmidt-Wolf, Ulrich Jaehde
Most anticancer agents exhibit a narrow therapeutic index, i.e., a small change in plasma concentrations can lead to a less efficacious treatment or an unacceptable degree of toxicity. This study aimed at providing health professionals with a feasible and time-saving tool to adapt the dose of anticancer agents for patients with renal or hepatic dysfunction. A guideline for anticancer agents was developed based on a literature search. An algorithm was generated to enhance the efficiency of the dose adaptation process...
February 27, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28218683/antimutagenic-activity-of-ethanol-extract-of-rhaphidophora-pinnata-l-f-schott-leaves-on-mice
#11
Masfria, Sumaiyah, Aminah Dalimunthe
Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract of Rhaphidophora pinnata leaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice (20-30 g) were treated for sevendays with an ethanol extract of Rhaphidophora pinnata leaves at a dose of 500, 750 and 1000 mg/kg/day/orally, prior to exposure to cyclophosphamide (i.p. 30 mg/kg), 24 h after the end of the treatment. Antimutagenic activity was determined by the decrease of micronuclei (MN)...
February 17, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28212319/a-validated-stability-indicating-hplc-method-for-simultaneous-determination-of-amoxicillin-and-enrofloxacin-combination-in-an-injectable-suspension
#12
Nidal Batrawi, Shorouq Wahdan, Fuad Al-Rimawi
The combination of amoxicillin and enrofloxacin is a well-known mixture of veterinary drugs; it is used for the treatment of Gram-positive and Gram-negative bacteria. In the scientific literature, there is no high-performance liquid chromatography (HPLC)-UV method for the simultaneous determination of this combination. The objective of this work is to develop and validate an HPLC method for the determination of this combination. In this regard, a new, simple and efficient reversed-phase HPLC method for simultaneous qualitative and quantitative determination of amoxicillin and enrofloxacin, in an injectable preparation with a mixture of inactive excipients, has been developed and validated...
February 16, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28157163/transmission-electron-microscopy-of-xdr-mycobacterium-tuberculosis-isolates-grown-on-high-dose-of-o%C3%AF-oxacin
#13
Mohammad Arjomandzadegan, Maryam Sadrnia, Leonid Titov, Larissa Surkova, Hossein Sarmadian, Reza Ghasemikhah, Hossein Hosseiny
The aim of the study was to investigate behavior of resistant Mycobacterium tuberculosis (MTB) isolates under a high dose of ofloxacin and its morphological changes. 19 extensively drug resistant (XDR) clinical isolates of MTB were grown on Löwenstein-Jensen medium containing progressively increasing concentrations of ofloxacin (2, 4, 8, 16, 32 mg/L). Ultra-structure analyses of resistant isolates grown on ofloxacin were conducted by transmission electron microscopy (TEM). Fixation was carried out by 4% glutaraldehyde in 0...
February 2, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28134827/natural-products-as-new-treatment-options-for-trichomoniasis-a-molecular-docking-investigation
#14
Mary Snow Setzer, Kendall G Byler, Ifedayo Victor Ogungbe, William N Setzer
Trichomoniasis, caused by the parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually-transmitted disease, and there can be severe complications from trichomoniasis. Antibiotic resistance in T. vaginalis is increasing, but there are currently no alternatives treatment options. There is a need to discover and develop new chemotherapeutic alternatives. Plant-derived natural products have long served as sources for new medicinal agents, as well as new leads for drug discovery and development...
January 27, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28134775/chrysin-protects-rat-kidney-from-paracetamol-induced-oxidative-stress-inflammation-apoptosis-and-autophagy-a-multi-biomarker-approach
#15
Fatih Mehmet Kandemir, Sefa Kucukler, Eyup Eldutar, Cuneyt Caglayan, İlhami Gülçin
Paracetamol (PC) is a safe analgesic and antipyretic drug at therapeutic doses, and it is widely used in clinics. However, at high doses, it can induce hepatotoxicity and nephrotoxicity. Chrysin (CR) is a natural flavonoid that has biological activities that include being an antioxidant, an anti-inflammatory, and an anti-cancer agent. The main objective of this study was to investigate the efficacy of CR against PC-induced nephrotoxicity in rats. CR was given orally via feeding needle to male Sprague Dawley rats as a single daily dose of 25 or 50 mg/kg for six days...
January 26, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28085092/new-synthesis-structure-and-analgesic-properties-of-methyl-1-r-4-methyl-2-2-dioxo-1h-2%C3%AE-%C3%A2-1-benzothiazine-3-carboxylates
#16
Liliana Azotla-Cruz, Irina V Lijanova, Igor V Ukrainets, Natalya V Likhanova, Octavio Olivares-Xometl, Natalya L Bereznyakova
According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylates has been obtained as potential analgesics. In addition, a fundamentally new strategy for the synthesis of compounds of this chemical class involving the introduction of N-alkyl substituent at the final stage in 2,1-benzothiazine nucleus already formed has been proposed. Using nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and X-ray diffraction analysis it has been proven that in the DMSO/K₂CO₃ system the reaction of methyl 4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylate and alkyl halides leads to formation of N-substituted derivatives with good yields regardless of the structure of the alkylating agent...
January 12, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28054999/interaction-between-dna-and-drugs-having-protonable-basic-groups-characterization-through-affinity-constants-drug-release-kinetics-and-conformational-changes
#17
Liliana P Alarcón, Yolima Baena, Rubén H Manzo
This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the reversibility of the interaction, and the effect on the secondary structure of the macromolecule. Affinity constants of the counterionic condensation DNA-drug were in the order of 10⁶. The negative electrokinetic potential of DNA decreased with the increase of the proportion of loading drugs. The drugs were slowly released from the DNA-drug complexes and had release kinetics consistent with the high degree of counterionic condensation...
January 4, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27918429/correction-budiarto-bugi-ratno-and-desriani-detection-of-her2-gene-polymorphism-in-breast-cancer-pcr-optimization-study-sci-pharm-2016-84-103-111
#18
Bugi Ratno Budiarto, Desriani
The authors wish to make the following corrections to their paper [1]:[...].
December 2, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27916830/influence-of-fragrances-on-human-psychophysiological-activity-with-special-reference-to-human-electroencephalographic-response
#19
REVIEW
Kandhasamy Sowndhararajan, Songmun Kim
The influence of fragrances such as perfumes and room fresheners on the psychophysiological activities of humans has been known for a long time, and its significance is gradually increasing in the medicinal and cosmetic industries. A fragrance consists of volatile chemicals with a molecular weight of less than 300 Da that humans perceive through the olfactory system. In humans, about 300 active olfactory receptor genes are devoted to detecting thousands of different fragrance molecules through a large family of olfactory receptors of a diverse protein sequence...
November 29, 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/27869754/a-comparative-pharmacokinetics-study-of-the-anti-parkinsonian-drug-pramipexole
#20
Ratih S I Putri, Effi Setiawati, Syifa A Aziswan, Fenny Ong, Raymond R Tjandrawinata, Liana W Susanto
The present study aimed to compare pharmacokinetic parameters of two pramipexole 0.25 mg formulations in order to show bioequivalence. The study was conducted in a randomized, open-label, two-period, two-sequence, and crossover design, involving 23 healthy volunteers. One of the 0.25 mg formulations of pramipexole evaluated in the study was manufactured by PT Dexa Medica, Palembang, Indonesia, the other, used as the reference, by Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany. All eligible subjects were required to fast before each drug administration period, which was separated by a one-week washout period...
November 18, 2016: Scientia Pharmaceutica
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