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IEEE Transactions on Bio-medical Engineering

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https://www.readbyqxmd.com/read/28328498/a-framework-for-patient-state-tracking-by-classifying-multiscalar-physiologic-waveform-features
#1
Benjamin Vandendriessche, Mustafa Abas, Thomas Dick, Kenneth Loparo, Frank Jacono
OBJECTIVE: State-of-the-art algorithms that quantify nonlinear dynamics in physiologic waveforms are underutilized clinically due to their esoteric nature. We present a generalizable framework for classifying multiscalar waveform features, designed for patient-state tracking directly at the bedside. METHODS: An artificial neural network classifier was designed to evaluate multiscale waveform features against a fingerprint database of multifractal synthetic time series...
March 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28328497/synergistic-effects-of-nanodrug-ultrasound-hyperthermia-and-thermal-ablation-on-solid-tumors-an-animal-study
#2
Li-Chen Chiu, Sheng-Kai Wu, Win-Li Lin, Gin-Shin Chen
OBJECTIVE: Delivery barriers of nanodrug in large tumors due to heterogeneous blood supply, elevated interstitial pressure and long transport distances can degrade the efficacy of cancer treatment. In this study, we proposed a therapeutic strategy to improve the tumor growth inhibition by injecting pegylated liposomal doxorubicin (PLD), and then applying a short time of ultrasound hyperthermia (HT) on the entire solid tumor, and inflicting ultrasound thermal ablation (Ab) in the low-perfused tumor region...
March 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28287955/accurate-3-d-profile-extraction-of-skull-bone-using-an-ultrasound-matrix-array
#3
Mehdi Hajian, Robert Gaspar, Roman Maev
The present study investigates the feasibility, accuracy, and precision of 3-D profile extraction of the human skull bone using a custom-designed ultrasound matrix transducer in Pulse-Echo. Due to the attenuative scattering properties of the skull, the backscattered echoes from the inner surface of the skull are severely degraded, attenuated, and at some points overlapped. Furthermore, the speed of sound (SOS) in the skull varies significantly in different zones and also from case to case; if considered constant, it introduces significant error to the profile measurement...
March 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28287954/refined-composite-multiscale-dispersion-entropy-and-its-application-to-biomedical-signals
#4
Hamed Azami, Mostafa Rostaghi, Dani Abasolo, Javier Escudero
OBJECTIVE: We propose a novel complexity measure to overcome the deficiencies of the widespread and powerful multiscale entropy (MSE), including, MSE values may be undefined for short signals, and MSE is slow for real-time applications. METHODS: We introduce multiscale dispersion entropy (DisEn - MDE) as a very fast and powerful method to quantify the complexity of signals. MDE is based on our recently developed DisEn, which has a computation cost of O(N), compared with O(N2) for sample entropy used in MSE...
March 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28287953/quantitative-comparison-of-spherical-deconvolution-approaches-to-resolve-complex-fiber-configurations-in-diffusion-mri-isra-based-vs-l2l0-sparse-methods
#5
Alfonso Mastropietro, Paola Scifo, Giovanna Rizzo
OBJECTIVE: To quantitatively compare different Spherical Deconvolution (SD) approaches (ISRA-based and sparse L2L0 algorithms) to resolve crossing fiber in diffusion MRI. The purpose of this comparison is to address the area of application in which each approach could better perform. METHODS: ISRA-based (Richardson-Lucy (RL), damped-RL) and sparse L2L0 algorithms were implemented and evaluated on both simulated data and in vivo datasets. Simulations were performed at different crossing angles (30° to 90°), b-values (1000 to 3000 s/mm (2) ), SNR (10 to 30), number of fibers (1 to 3)...
March 6, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28278455/3d-gaze-based-robotic-grasping-through-mimicking-human-visuomotor-function-for-people-with-motion-impairments
#6
Songpo Li, Xiaoli Zhang, Jeremy Webb
OBJECTIVE: The goal of this paper is to achieve a novel 3D-gaze-based human-robot-interaction modality, with which a user with motion impairment can intuitively express what tasks he/she wants the robot to do by directly looking at the object of interest in the real world. Toward this goal, we investigate 1) the technology to accurately sense where a person is looking in real environments and 2) the method to interpret the human gaze and convert it into an effective interaction modality...
March 3, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28278451/reference-free-adjustment-of-respiratory-inductance-plethysmography-for-measurements-during-physical-exercise
#7
Heike Leutheuser, Christian Heyde, Kai Roecker, Albert Gollhofer, Bjoern Eskofier
OBJECTIVE: Respiratory inductance plethysmography (RIP) provides an unobtrusive method for measuring breathing characteristics. Accurately adjusted RIP provides reliable measurements of ventilation during rest and exercise if data are acquired via two elastic measuring bands surrounding the rib cage (RC) and abdomen (AB). Disadvantageously, the most accurate reported adjusted model for RIP in literature-least squares regression-requires simultaneous RIP and flowmeter (FM) data acquisition...
March 3, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28278454/accurate-wearable-heart-rate-monitoring-during-physical-exercises-using-ppg
#8
Andriy Temko
OBJECTIVE: The challenging task of heart rate (HR) estimation from the photoplethysmographic (PPG) signal, during intensive physical exercises is tackled in this paper. METHODS: The study presents a detailed analysis of a novel algorithm (WFPV) that exploits a Wiener filter to attenuate the motion artifacts, a phase vocoder to refine the HR estimate and user-adaptive postprocessing to track the subject physiology. Additionally, an offline version of the HR estimation algorithm that uses Viterbi decoding is designed for scenarios that do not require online HR monitoring (WFPV+VD)...
March 1, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28278453/living-skin-classification-via-remote-ppg
#9
Wenjin Wang, Sander Stuijk, Gerard de Haan
Detecting living-skin tissue in a video on the basis of induced color changes due to blood pulsation is emerging for automatic region of interest localization in remote photoplethysmography (rPPG). However, the state-of-the-art method performing unsupervised living-skin detection in a video is rather time-consuming, which is mainly due to the high complexity of its unsupervised on-line learning for pulse/noise separation. In this paper, we address this issue by proposing a fast living-skin classification method...
March 1, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28278452/identification-of-ultrasonic-echolucent-carotid-plaques-using-discrete-fr%C3%A3-chet-distance-between-bimodal-gamma-distributions
#10
Xiaowei Huang, Yanling Zhang, Long Meng, Ming Qian, Kelvin Wong, Derek Abbott, Rongqin Zheng, Hairong Zheng, Lili Niu
OBJECTIVE: Echolucent carotid plaques are associated with acute cardiovascular and cerebrovascular events (ACCEs) in atherosclerotic patients. The aim of this study was to develop a computer-aided method for identifying echolucent plaques. METHODS: A total of 315 ultrasound images of carotid plaques (105 echo-rich, 105 intermediate and 105 echolucent) collected from 153 patients were included in this study. A bimodal gamma distribution was proposed to model the pixel statistics in the gray scale images of plaques...
March 1, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28252389/simultaneous-measurement-of-multiple-mechanical-properties-of-single-cells-using-afm-by-indentation-and-vibration
#11
Chuang Zhang, Jialin Shi, Wenxue Wang, Ning Xi, Yuechao Wang, Lianqing Liu
OBJECTIVE: The mechanical properties of cells, which are the main characteristics determining their physical performance and physiological functions, have been actively studied in the fields of cytobiology and biomedical engineering and for the development of medicines. In this study, an indentation-vibration-based method is proposed to simultaneously measure the mechanical properties of cells in situ, including cellular mass (m), elasticity (k) and viscosity (c). METHODS: The proposed measurement method is implemented based on the principle of forced vibration stimulated by simple harmonic force using an atomic force microscope (AFM) system integrated with a piezoelectric transducer (PZT) as the substrate vibrator...
February 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28252388/three-dimensional-segmentation-of-the-ex-vivo-anterior-lamina-cribrosa-from-second-harmonic-imaging-microscopy
#12
Sundaresh Ram, Forest Danford, Stephen Howerton, Jeffrey Rodriguez, Jonathan Vande Geest
The lamina cribrosa (LC) 1 is a connective tissue in the posterior eye with a complex mesh-like trabecular microstructure through which all the retinal ganglion cell axons and central retinal vessels pass. Recent studies have demonstrated that changes in the structure of the LC correlate with glaucomatous damage. Thus, accurate segmentation and reconstruction of the LC is of utmost importance. This paper presents a new automated method for segmenting the microstructure of the anterior LC in the images obtained via multiphoton microscopy using a combination of ideas...
February 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28252387/gait-phase-estimation-based-on-noncontact-capacitive-sensing-and-adaptive-oscillators
#13
Enhao Zheng, Silvia Manca, Tingfang Yan, Andrea Parri, Nicola Vitiello, Qining Wang
This paper presents a novel strategy aiming to acquire an accurate and walking-speed-adaptive estimation of the gait phase through noncontact capacitive sensing and adaptive oscillators (AOs). The capacitive sensing system is designed with two sensing cuffs that can measure the leg muscle shape changes during walking. The system can be dressed above the clothes and free human skin from contacting to electrodes. In order to track the capacitance signals, the gait phase estimator is designed based on the AOs dynamic system due to its ability of synchronizing with quasi-periodic signals...
February 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28237919/the-relation-between-the-frequency-of-short-pulse-electrical-stimulation-of-afferent-nerve-fibers-and-evoked-muscle-force
#14
Jakob L Dideriksen, Kasper Leerskov, Magdalena Czyzewska, Rune Rasmussen
OBJECTIVE: Functional electrical stimulation (FES) is conventionally performed by the stimulation of motor axons causing the muscle fibers innervated by these axons to contract. An alternative strategy that may evoke contractions with more natural motor unit behavior is to stimulate afferent fibers (primarily type Ia) to excite the motor neurons at the spinal level. The aim of the study was to investigate the range of forces that can be evoked in this way and the degree to which the torque can be controlled...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28237918/optimal-control-of-inspired-perfluorocarbon-temperature-for-ultrafast-hypothermia-induction-by-total-liquid-ventilation-in-adult-patient-model
#15
Mathieu Nadeau, Michael Sage, Matthias Kohlhauer, Julien Mousseau, Jonathan Vandamme, Etienne Fortin-Pellerin, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau
OBJECTIVE: Recent preclinical studies have shown that therapeutic hypothermia induced in less than 30 min by total liquid ventilation (TLV) strongly improves the survival rate after cardiac arrest. When the lung is ventilated with a breathable perfluorocarbon liquid, the inspired perfluorocarbon allows to control efficiently the cooling process of the organs. While TLV can rapidly cool animals, the cooling speed in humans remains unknown. The objective is to predict the efficiency and safety of ultrafast cooling by TLV in adult humans...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28237917/detection-of-motor-impairment-in-parkinson-s-disease-via-mobile-touchscreen-typing
#16
Teresa Arroyo-Gallego, Maria Jesus Ledesma-Carbayo, Alvaro Sanchez-Ferro, Ian Butterworth, Carlos Sanchez-Mendoza, Michele Matarazzo, Paloma Montero, Roberto Lopez-Blanco, Veronica Puertas-Martin, Rocio Trincado, Luca Giancardo
Mobile technology is opening a wide range of opportunities for transforming the standard of care for chronic disorders. Using smartphones as tools for longitudinally tracking symptoms could enable personalization of drug regimens and improve patient monitoring. Parkinson's disease (PD) is an ideal candidate for these tools. At present, evaluation of PD signs requires trained experts to quantify motor impairment in the clinic, limiting the frequency and quality of the information available for understanding the status and progression of the disease...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28237916/real-time-assessment-of-mechanical-tissue-trauma-in-surgery
#17
James H Chandler, Faisal Mushtaq, Benjamin Moxley-Wyles, Nicholas P West, Gregory W Taylor, Peter R Culmer
This work presents a method to assess and prevent tissue trauma in real-time during surgery. BACKGROUND: Tissue trauma occurs routinely during laparoscopic surgery with potentially severe consequences. As such, it is crucial that a surgeon is able to regulate the pressure exerted by surgical instruments. We propose a novel method to assess the onset of tissue trauma by considering the mechanical response of tissue as it is loaded in real-time. METHODS: We conducted a parametric study using a lab-based grasping model and differing load conditions...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28221991/detecting-clinically-meaningful-shape-clusters-in-medical-image-data-metrics-analysis-for-hierarchical-clustering-applied-to-healthy-and-pathological-aortic-arches
#18
Jan L Bruse, Maria A Zuluaga, Abbas Khushnood, Kristin McLeod, Hopewell N Ntsinjana, Tain-Yen Hsia, Maxime Sermesant, Xavier Pennec, Andrew M Taylor, Silvia Schievano
OBJECTIVE: Today's growing medical image databases call for novel processing tools to structure the bulk of data and extract clinically relevant information. Unsupervised hierarchical clustering may reveal clusters within anatomical shape data of patient populations as required for modern Precision Medicine strategies. Few studies have applied hierarchical clustering techniques to three-dimensional patient shape data and results depend heavily on the chosen clustering distance metrics and linkage functions...
February 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28212076/selecting-power-efficient-signal-features-for-a-low-power-fall-detector
#19
Changhong Wang, Stephen Redmond, Wei Lu, Michael Stevens, Stephen Lord, Nigel Lovell
Falls are a serious threat to the health of older people. A wearable fall detector can automatically detect the occurrence of a fall and alert a caregiver or an emergency response service so they may deliver immediate assistance, improving the chances of recovering from fall-related injuries. One constraint of such a wearable technology is its limited battery life. Thus, minimization of power consumption is an important design concern, all the while maintaining satisfactory accuracy of the fall detection algorithms implemented on the wearable device...
February 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28212074/a-review-of-in-body-biotelemetry-devices-implantables-ingestibles-and-injectables
#20
Asimina Kiourti, Konstantina S Nikita
We present a review of wireless medical devices that are placed inside the human body to realize many and different sensing and/or stimulating functionalities. METHODS: A critical literature review analysis is conducted focusing on three types of in-body medical devices, i.e., a) devices that are implanted inside the human body (implantables), b) devices that are ingested like regular pills (ingestibles), and c) devices that are injected into the human body via needles (injectables). Design considerations, current status and future directions related to the aforementioned in-body devices are discussed...
February 14, 2017: IEEE Transactions on Bio-medical Engineering
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