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IEEE Transactions on Bio-medical Engineering

Alba Martin-Yebra, Violeta Monasterio, Iwona Cygankiewicz, Antoni Bayes-de-Luna, Enrico G Caiani, Pablo Laguna, Juan Pablo Martinez
OBJECTIVE: We proposed and evaluated a method for correcting possible phase shifts provoked by the presence of ventricular premature contractions (VPCs) for a better assessment of T-wave alternans (TWA). Methods: First, we synthesized ECG signals with artificial TWA in the presence of different noise sources. Then, we assessed the prognostic value for sudden cardiac death (SCD) of the long-term average of TWA amplitude (the index of average alternans, ) in ambulatory ECG signals from congestive heart failure (CHF) and evaluated whether it is sensitive to the presence of VPCs...
March 2018: IEEE Transactions on Bio-medical Engineering
Mina Khoshdeli, Bahram Parvin
Detection of nuclei is an important step in phenotypic profiling of 1) histology sections imaged in bright field; and 2) colony formation of the 3-D cell culture models that are imaged using confocal microscopy. It is shown that feature-based representation of the original image improves color decomposition (CD) and subsequent nuclear detection using convolutional neural networks independent of the imaging modality. The feature-based representation utilizes the Laplacian of Gaussian (LoG) filter, which accentuates blob-shape objects...
March 2018: IEEE Transactions on Bio-medical Engineering
Da Woon Jung, Su Hwan Hwang, Jae Geol Cho, Byung Hun Choi, Hyun Jae Baek, Yu Jin Lee, Do-Un Jeong, Kwang Suk Park
OBJECTIVE: Nocturnal pulse oximetry has been proposed as a simpler alternative to polysomnography in diagnosing sleep apnea. However, existing techniques are limited in terms of inability to provide time information on sleep apnea occurrence. This study aimed to propose a new strategy for near real-time automatic detection of apneic events and reliable estimation of apnea-hypopnea index using nocturnal pulse oximetry. METHODS: Among 230 polysomnographic recordings with apnea-hypopnea index values ranging from 0 to 86...
March 2018: IEEE Transactions on Bio-medical Engineering
Janja Dermol-Cerne, Damijan Miklavcic
Current models of tissue electroporation either describe tissue with its bulk properties or include cell level properties, but model only a few cells of simple shapes in low-volume fractions or are in two dimensions. We constructed a three-dimensional model of realistically shaped cells in realistic volume fractions. By using a 'unit cell' model, the equivalent dielectric properties of whole tissue could be calculated. We calculated the dielectric properties of electroporated skin. We modeled electroporation of single cells by pore formation on keratinocytes and on the papillary dermis which gave dielectric properties of the electroporated epidermis and papillary dermis...
February 2018: IEEE Transactions on Bio-medical Engineering
Wenxing Hu, Dongdong Lin, Shaolong Cao, Jingyu Liu, Jiayu Chen, Vince D Calhoun, Yu-Ping Wang
Finding correlations across multiple data sets in imaging and (epi)genomics is a common challenge. Sparse multiple canonical correlation analysis (SMCCA) is a multivariate model widely used to extract contributing features from each data while maximizing the cross-modality correlation. The model is achieved by using the combination of pairwise covariances between any two data sets. However, the scales of different pairwise covariances could be quite different and the direct combination of pairwise covariances in SMCCA is unfair...
February 2018: IEEE Transactions on Bio-medical Engineering
Ewan S Nurse, Sam E John, Dean R Freestone, Thomas J Oxley, Hoameng Ung, Samuel F Berkovic, Terence J O'Brien, Mark J Cook, David B Grayden
OBJECTIVE: Subdural electrocorticography (ECoG) can provide a robust control signal for a brain-computer interface (BCI). However, the long-term recording properties of ECoG are poorly understood as most ECoG studies in the BCI field have only used signals recorded for less than 28 days. We assessed human ECoG recordings over durations of many months to investigate changes to recording quality that occur with long-term implantation. METHODS: We examined changes in signal properties over time from 15 ambulatory humans who had continuous subdural ECoG monitoring for 184-766 days...
February 2018: IEEE Transactions on Bio-medical Engineering
Yuankai Huo, Jiaqi Liu, Zhoubing Xu, Robert L Harrigan, Albert Assad, Richard G Abramson, Bennett A Landman
OBJECTIVE: Magnetic resonance imaging (MRI) is an essential imaging modality in noninvasive splenomegaly diagnosis. However, it is challenging to achieve spleen volume measurement from three-dimensional MRI given the diverse structural variations of human abdomens as well as the wide variety of clinical MRI acquisition schemes. Multi-atlas segmentation (MAS) approaches have been widely used and validated to handle heterogeneous anatomical scenarios. In this paper, we propose to use MAS for clinical MRI spleen segmentation for splenomegaly...
February 2018: IEEE Transactions on Bio-medical Engineering
Terence P Mayne, Niranchan Paskaranandavadivel, Jonathan C Erickson, Gregory OGrady, Leo K Cheng, Timothy R Angeli
OBJECTIVE: High-resolution mapping of gastrointestinal (GI) slow waves is a valuable technique for research and clinical applications. Interpretation of high-resolution GI mapping data relies on animations of slow wave propagation, but current methods remain as rudimentary, pixelated electrode activation animations. This study aimed to develop improved methods of visualizing high-resolution slow wave recordings that increases ease of interpretation. METHODS: The novel method of "wavefront-orientation" interpolation was created to account for the planar movement of the slow wave wavefront, negate any need for distance calculations, remain robust in atypical wavefronts (i...
February 2018: IEEE Transactions on Bio-medical Engineering
Qi Wei, Dinesh K Pai, Matthew C Tresch
Subject-specific musculoskeletal models are increasingly used in biomedical applications to predict endpoint forces due to muscle activation, matching predicted forces to experimentally observed forces at a specific limb configuration. However, it is difficult to precisely measure the limb configuration at which these forces are observed. The consequent uncertainty in limb configuration might contribute to errors in model predictions. We therefore evaluated how uncertainties in limb configuration measurement contributed to errors in force prediction, using data from in vivo measurements in the rat hindlimb...
February 2018: IEEE Transactions on Bio-medical Engineering
Fanette Chassagne, Jerome Molimard, Reynald Convert, Pascal Giraux, Pierre Badel
OBJECTIVE: To develop a new method for the prediction of interface pressure applied by medical compression bandages. METHODS: A finite element simulation of bandage application was designed, based on patient-specific leg geometries. For personalized interface pressure prediction, a model reduction approach was proposed, which included the parametrization of the leg geometry. Pressure values computed with this reduced model were then confronted to experimental pressure values...
February 2018: IEEE Transactions on Bio-medical Engineering
Kaiyu Wang, Yuqing Huang, Pieter E S Smith, Zhiyong Zhang, Shuhui Cai, Zhong Chen
OBJECTIVE: A method is proposed to obtain high-resolution 2-D -resolved nuclear magnetic resonance (NMR) spectra in inhomogeneous magnetic fields. METHODS: The proposed experiment enables the acquisition of an entire 2-D spectrum in a single scan by utilizing intermolecular double-quantum coherences and the spatial encoding of NMR observables. RESULTS: Chemical shifts, coupling constants, and multiplet patterns are recovered even when field inhomogeneities are severe enough to completely obscure conventional NMR spectra...
February 2018: IEEE Transactions on Bio-medical Engineering
Sehoon Jeong, Sunja Kim, John Buonocore, Jaewon Park, C Jane Welsh, Jianrong Li, Arum Han
OBJECTIVE: The blood-brain barrier (BBB) poses a unique challenge to the development of therapeutics against neurological disorders due to its impermeabi-lity to most of the chemical compounds. Most in vitro BBB models have limitations in mimicking in vivo conditions and functions. Here, we show a co-culture microfluidic BBB-on-a-chip that provides interactions between neurovascular endothelial cells and neuronal cells across a porous polycarbonate membrane, which better mimics the in vivo conditions, as well as allows in vivo level shear stress to be applied...
February 2018: IEEE Transactions on Bio-medical Engineering
Adrian Zurbuchen, Andreas Haeberlin, Lukas Bereuter, Alois Pfenniger, Simon Bosshard, Micha Kernen, Paul Philipp Heinisch, Juerg Fuhrer, Rolf Vogel
OBJECTIVE: cardiac pacemakers require regular medical follow-ups to ensure proper functioning. However, device replacements due to battery depletion are common and account for ∼25% of all implantation procedures. Furthermore, conventional pacemakers require pacemaker leads which are prone to fractures, dislocations or isolation defects. The ensuing surgical interventions increase risks for the patients and costs that need to be avoided. METHODS: in this study, we present a method to harvest energy from endocardial heart motions...
February 2018: IEEE Transactions on Bio-medical Engineering
Luciano Mescia, Michele A Chiapperino, Pietro Bia, Johan Gielis, Diego Caratelli
During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clarified, many research activities are focused on the development of suitable theoretical and numerical models. To this end, a nonlinear, nonlocal, dispersive, and space-time numerical algorithm has been developed and adopted to evaluate the transmembrane voltage and pore density along the perimeter of realistic irregularly shaped cells...
February 2018: IEEE Transactions on Bio-medical Engineering
Herng-Hua Chang, Cheng-Yuan Li, Audrey Haihong Gallogly
OBJECTIVE: Noise reduction in brain magnetic resonance (MR) images has been a challenging and demanding task. This study develops a new trilateral filter that aims to achieve robust and efficient image restoration. METHODS: Extended from the bilateral filter, the proposed algorithm contains one additional intensity similarity funct-ion, which compensates for the unique characteristics of noise in brain MR images. An entropy function adaptive to intensity variations is introduced to regulate the contributions of the weighting components...
February 2018: IEEE Transactions on Bio-medical Engineering
Zhencheng Fan, Guowen Chen, Junchen Wang, Hongen Liao
We develop a spatial position measurement system using three-dimensional (3-D) image marker-based tracking tools targeted at surgical navigation in minimally invasive surgery. We generate 3-D image markers with spatial information encoded to 2-D images, design tracking tools with the 3-D image markers, and analyze the tracking tools' theoretical spatial errors, which are primarily limited by the spatial distribution of reconstructed fiducial 3-D markers. A pattern analysis-based positional measurement algorithm is developed to calculate the tool's spatial information using its spatial configuration...
February 2018: IEEE Transactions on Bio-medical Engineering
Wanchat Theeranaew, James McDonald, Bilal Zonjy, Farhad Kaffashi, Brian D Moseley, Daniel Friedman, Elson So, James Tao, Maromi Nei, Philippe Ryvlin, Rainer Surges, Roland Thijs, Stephan Schuele, Samden Lhatoo, Kenneth A Loparo
Although there is no strict consensus, some studies have reported that Postictal generalized EEG suppression (PGES) is a potential electroencephalographic (EEG) biomarker for risk of sudden unexpected death in epilepsy (SUDEP). PGES is an epoch of EEG inactivity after a seizure, and the detection of PGES in clinical data is extremely difficult due to artifacts from breathing, movement and muscle activity that can adversely affect the quality of the recorded EEG data. Even clinical experts visually interpreting the EEG will have diverse opinions on the start and end of PGES for a given patient...
February 2018: IEEE Transactions on Bio-medical Engineering
Che-Hao Yang, Wei Li, Roland K Chen
Electrosurgical vessel joining is commonly performed in surgical procedures to maintain hemostasis. This process requires elevated temperature to denature the tissue and while compression is applied, the tissue can be joined together. The elevated temperature can cause thermal damages to the surrounding tissues. In order to minimize these damages, it is critical to understand how the tissue properties change and how that affects the thermal spread. The purpose of this study is to investigate the changes of tissue thermal conductivity and how the changes correlate to thermal dose during the joining process...
February 2018: IEEE Transactions on Bio-medical Engineering
Hongmin Cai, Peihua Chen, Jiazhou Chen, Jiulun Cai, Yan Song, Guoqiang Han
Copy-number variations (CNVs) are associated with complex diseases and particular tumor types. Array-based comparative genomic hybridization (aCGH) is a common approach for the detection of CNVs. Traditional CNV detection methods for multiple aCGH samples mainly use batch samples to find common variations, not accounting for the individual characteristics of each sample. Accurately differentiating both the commonly shared and the individual CNV patterns is pivotal to identify cell populations, or to distinguish cell growth (as in cancer) from invasion of new cells...
February 2018: IEEE Transactions on Bio-medical Engineering
Christopher Kenneth Giardina, Elliot Samuel Krause, Kanthaiah Koka, Douglas Carl Fitzpatrick
OBJECTIVE: Improper electrode placement during cochlear implant (CI) insertion can adversely affect speech perception outcomes. However, the intraoperative methods to determine positioning are limited. Because measures of electrode impedance can be made quickly, the goal of this study was to assess the relationship between CI impedance and proximity to adjacent structures. METHODS: An Advanced Bionics CI array was inserted into a clear, plastic cochlea one electrode contact at a time in a saline bath (nine trials)...
February 2018: IEEE Transactions on Bio-medical Engineering
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