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IEEE Transactions on Bio-medical Engineering

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https://www.readbyqxmd.com/read/28922112/effects-of-flexible-dry-electrode-design-on-electrodermal-activity-stimulus-response-detection
#1
Peter A Haddad, Amir Servati, Saeid Soltanian, Frank Ko, Peyman Servati
OBJECTIVE: The focus of this research is to evaluate the effects of design parameters including surface area, distance between and geometry of dry flexible electrodes on electrodermal activity (EDA) stimulus response detection. METHODS: EDA is a result of the autonomic nervous system (ANS) being stimulated, which causes sweat and changes the electrical characteristics of the skin. Standard silver/silver chloride (Ag/AgCl) EDA electrodes are rigid and lack conformability in contact with skin...
September 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28922111/optimization-of-the-working-conditions-for-magnetic-nanoparticle-enhanced-microwave-diagnostics-of-breast-cancer
#2
Gennaro Bellizzi, Gennaro G Bellizzi, Ovidio M Bucci, Lorenzo Crocco, Marko Helbig, Sebastian Ley, Juergen Sachs
Magnetic nanoparticle-aided microwave imaging is recently gaining an increasing interest as potential tool for breast cancer diagnostics. This is due to the peculiar features of magnetic nanoparticles, which are biocompatible, can be selectively targeted to the tumor and may change their microwave magnetic response when modulated by a polarizing magnetic field. This latter aspect is particularly appealing, as it enables the physical separation of the microwave signal due the malignancy, targeted by the nanoparticles, from that due to healthy tissue...
September 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28922110/an-automated-system-for-the-detection-and-classification-of-retinal-changes-due-to-red-lesions-in-longitudinal-fundus-images
#3
Kedir M Adal, Peter G van Etten, Jose P Martinez, Kenneth W Rouwen, Koenraad A Vermeer, Lucas J van Vliet
People with diabetes mellitus need annual screening to check for the development of diabetic retinopathy. Tracking small retinal changes due to early diabetic retinopathy lesions in longitudinal fundus image sets is challenging due to intra- and inter-visit variability in illumination and image quality, the required high registration accuracy, and the subtle appearance of retinal lesions compared to other retinal features. This paper presents a robust and flexible approach for automated detection of longitudinal retinal changes due to small red lesions by exploiting normalized fundus images that significantly reduce illumination variations and improve the contrast of small retinal features...
September 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920895/matched-filtering-for-heart-rate-estimation-on-compressive-sensing-ecg-measurements
#4
Giulia Da Poian, Christopher J Rozell, Riccardo Bernardini, Roberto Rinaldo, Gari D Clifford
OBJECTIVE: Compressive Sensing (CS) has recently been applied as a low complexity compression framework for long-term monitoring of electrocardiogram signals using Wireless Body Sensor Networks. Long-term recording of ECG signals can be useful for diagnostic purposes and to monitor the evolution of several widespread diseases. In particular, beat to beat intervals provide important clinical information, and these can be derived from the ECG signal by computing the distance between QRS complexes (R-peaks)...
September 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920894/electro-thermal-equivalent-3d-finite-element-model-of-a-single-neuron
#5
I Cinelli, M Destrade, M Duffy, P McHugh
OBJECTIVE: We propose a novel approach for modelling the inter-dependence of electrical and mechanical phenomena in nervous cells, by using electro-thermal equivalences in finite element (FE) analysis so that existing thermo-mechanical tools can be applied. METHODS: First, the equivalence between electrical and thermal properties of the nerve materials is established, and results of a pure heat conduction analysis performed in Abaqus CAE Software 6.13-3 are validated with analytical solutions for a range of steady and transient conditions...
September 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920892/computationally-efficient-algorithms-for-sparse-dynamic-solutions-to-the-eeg-source-localization-problem
#6
Elvira Pirondini, Behtash Babadi, Gabriel Obregon-Henao, Camilo Lamus, Wasim Q Malik, Matti S Hamalainen, Patrick L Purdon
OBJECTIVE: Electroencephalography (EEG) and magnetoencephalography (MEG) non-invasively record scalp electromagnetic fields generated by cerebral currents, revealing millisecond-level brain dynamics useful for neuroscience and clinical applications. Estimating the currents that generate these fields, i.e., source localization, is an ill-conditioned inverse problem. Solutions to this problem have focused on spatial continuity constraints, dynamic modeling, or sparsity constraints. The combination of these key ideas could offer significant performance improvements, but substantial computational costs pose a challenge for practical application of such approaches...
September 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920893/a-functional-genetic-scheme-for-seizure-forecasting-in-canine-epilepsy
#7
E Bou Assi, D K Nguyen, S Rihana, M Sawan
OBJECTIVE: The objective of this work is the development of an accurate seizure forecasting algorithm that considers brain's functional connectivity for electrode selection. METHODS: We start by proposing Kmeans-directed transfer function, an adaptive functional connectivity method intended for seizure onset zone localization in bilateral intracranial EEG recordings. Electrodes identified as seizure activity sources and sinks are then used to implement a seizure-forecasting algorithm on long-term continuous recordings in dogs with naturallyoccurring epilepsy...
September 13, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28910754/a-phase-variable-approach-for-imu-based-locomotion-activity-recognition
#8
Harrison L Bartlett, Michael Goldfarb
OBJECTIVE: This paper describes a gait classification method which utilizes measured motion of the thigh segment provided by an inertial measurement unit (IMU). METHODS: The classification method employs a phase-variable description of gait, and identifies a given activity based on the expected curvature characteristics of that activity over a gait cycle. The classification method was tested in experiments conducted with seven healthy subjects performing three different locomotor activities: level ground walking, stair descent, and stair ascent...
September 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28885148/ultra-wideband-millimeter-wave-dielectric-characteristics-of-freshly-excised-normal-and-malignant-human-skin-tissues
#9
Amir Mirbeik-Sabzevari, Robin Ashinoff, Negar Tavassolian
Millimeter waves have recently gained attention for the evaluation of skin lesions and the detection of skin tumors. Such evaluations heavily rely on the dielectric contrasts existing between normal and malignant skin tissues at millimeter-wave frequencies. However, current studies on the dielectric properties of normal and diseased skin tissues at these frequencies are limited and inconsistent. In this work, a comprehensive dielectric spectroscopy study is conducted for the first time to characterize the ultra-wideband dielectric properties of freshly-excised normal and malignant skin tissues obtained from skin cancer patients having undergone Mohs micrographic surgeries at Hackensack University Medical Center...
September 6, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28885147/quantitative-susceptibility-mapping-qsm-algorithms-mathematical-rationale-and-computational-implementations
#10
Youngwook Kee, Zhe Liu, Liangdong Zhou, Alexey Dimov, Junghun Cho, Ludovic de Rochefort, Jin Keun Seo, Yi Wang
Quantitative susceptibility mapping (QSM) solves the magnetic field-to-magnetization (tissue susceptibility) inverse problem under conditions of noisy and incomplete field data acquired using magnetic resonance imaging. Sophisticated algorithms are, therefore, necessary to treat the ill-posed nature of the problem and are reviewed here. The forward problem is typically presented as an integral form, where the field is the convolution of the dipole kernel and tissue susceptibility distribution. This integral form can be equivalently written as a partial differential equation (PDE)...
September 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28880156/a-high-resolution-mini-microscope-system-for-wireless-real-time-monitoring
#11
Zongjie Wang, Akash Boddeda, Benjamin Parker, Roya Samanipour, Sanjoy Ghosh, Frederic Menard, Keekyoung Kim
OBJECTIVE: Compact, cost-effective and high-performance microscope that enables the real-time imaging of cells and lab-on-a-chip devices is highly demanded for cell biology and biomedical engineering. This paper aims to present the design and application of an inexpensive wireless mini-microscope with resolution up to 2592 × 1944 pixels and speed up to 90 fps. METHODS: The mini-microscope system was built on a commercial embedded system (Raspberry Pi). We modified a camera module and adopted an inverse dual lens system to obtain the clear field of view and appropriate magnification for tens of micrometer objects...
September 4, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28880155/identification-of-ion-currents-components-generating-field-potential-recorded-in-mea-from-hipsc-cm
#12
Fabien Raphel, Muriel Boulakia, Nejib Zemzemi, Yves Coudiere, Jean-Michel Guillon, Philippe Zitoun, Jean-Frederic Gerbeau
Multi Electrodes Arrays (MEAs) combined with cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) can enable high- or medium-throughput drug screening in safety pharmacology. This technology has recently attracted a lot of attention, in particular from an international initiative named CiPA. But it is currently limited by the difficulty to analyze the measured signals. We propose a strategy to analyze the signals acquired by the MEA and to automatically deduce the channels affected by the drug...
September 4, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28880154/micromagnetic-stimulation-of-the-mouse-auditory-cortex-in-vivo-using-an-implantable-solenoid-system
#13
Shunsuke Minusa, Hisayuki Osanai, Takashi Tateno
OBJECTIVE: Recent studies have reported that micromagnetic stimulation (μMS), which can activate neural tissue and cells via sub-millimeter inductors, may address several limitations of conventional magnetic stimulation methods. Previous studies have examined the effects of μMS on single neurons, yet little is known about how μMS can affect brain tissue including local neural networks. Here, we propose a new, readily available implantable μMS system and computationally and experimentally evaluate its validity...
September 1, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28866479/type-1-diabetes-patient-decision-simulator-for-in-silico-testing-safety-and-effectiveness-of-insulin-treatments
#14
M Vettoretti, A Facchinetti, G Sparacino, C Cobelli
OBJECTIVE: Type 1 diabetes (T1D) treatment requires exogenous insulin administrations finely tuned based on glucose monitoring to avoid hyper/hypoglycemia. The safety and effectiveness of insulin treatments is commonly assessed in clinical trials, which are time demanding and expensive. These limitations can be overtaken by in silico clinical trials (ISCT) that require realistic patient and treatment models. The aim is to develop a T1D patient decision simulator usable to perform reliable ISCT...
August 29, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28858782/acoustical-emission-analysis-by-unsupervised-graph-mining-a-novel-biomarker-of-knee-health-status
#15
Sinan Hersek, Maziyar Baran Pouyan, Caitlin N Teague, Michael N Sawka, Mindy L Millard-Stafford, Geza F Kogler, Paul Wolkoff, Omer T Inan
OBJECTIVE: To study knee acoustical emission patterns in subjects with acute knee injury immediately following injury and several months after surgery and rehabilitation. METHODS: We employed an unsupervised graph mining algorithm to visualize heterogeneity of the high-dimensional acoustical emission data, and to then derive a quantitative metric capturing this heterogeneity - the graph community factor (GCF). A total of 42 subjects participated in the studies. Measurements were taken once each from 33 healthy subjects with no known previous knee injury, and twice each from 9 subjects with unilateral knee injury: first, within seven days of the injury, and second, 4-6 months after surgery when the subjects were determined ready to start functional activities...
August 29, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28858781/epidermal-electrode-technology-for-detecting-ultrasonic-perturbation-of-sensory-brain-activity
#16
Stanley Huang, Jonathan A N Fisher, Meijun Ye, Yun-Soung Kim, Rui Ma, Marjan Nabili, Victor Krauthamer, Matthew R Myers, Todd P Coleman, Cristin G Welle
OBJECTIVE: We aim to demonstrate the in vivo capability of a wearable sensor technology to detect localized perturbations of sensory-evoked brain activity. METHODS: Cortical somatosensory evoked potentials (SSEPs) were recorded in mice via wearable, flexible epidermal electrode arrays. We then utilized the sensors to explore the effects of transcranial focused ultrasound, which noninvasively induced neural perturbation. SSEPs recorded with flexible epidermal sensors were quantified and benchmarked against those recorded with invasive epidural electrodes...
August 29, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28858783/molecularly-imprinted-polymer-based-electrochemical-biosensor-for-bone-loss-detection
#17
Nasrin Afsarimanesh, Subhas Chandra Mukhopadhyay, Marlena Kruger
Serum C-terminal telopeptide of type I collagen (CTx-I) assays quantify the fragment of CTx-I released throughout the procedure of bone remodeling. CTx-I is a key bone turnover biomarker where any variation in the level of CTx-I can be an indication of increased bone resorption. This study focuses on a new strategy for the prognosis of bone loss by monitoring the concentration of CTx-I in serum. An interdigital capacitive sensor together with Electrochemical Impedance Spectroscopy (EIS) was employed to assess the dielectric properties of the test solution...
August 25, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28858780/a-machine-learning-approach-to-automated-gait-analysis-for-the-noldus-catwalk-tm-system
#18
Holger Frohlich, Kasper Claes, Catherine De Wolf, Xavier Van Damme, Anne Michel
OBJECTIVE: Gait analysis of animal disease models can provide valuable insights into in vivo compound effects and thus help in preclinical drug development. The purpose of this paper is to establish a computational gait analysis approach for the Noldus Catwalk (TM) system, in which footprints are automatically captured and stored. METHODS: We present a - to our knowledge - first machine learning based approach for the Catwalk (TM) system, which comprises a step decomposition, definition and extraction of meaningful features, multivariate step sequence alignment, feature selection and training of different classifiers (Gradient Boosting Machine, Random Forest, Elastic Net)...
August 24, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28841547/a-750-mhz-electronically-tunable-resonator-using-microstrip-line-couplers-for-electron-paramagnetic-resonance-imaging-of-a-mouse-tumor-bearing-leg
#19
Tatsuya Amida, Ririko Nakaoka, Denis A Komarov, Kumiko Yamamoto, Osamu Inanami, Shingo Matsumoto, Hiroshi Hirata
OBJECTIVE: The purpose of this work was to develop an electronically tunable resonator operating at 750 MHz for continuous-wave electron paramagnetic resonance (CW-EPR) imaging of a mouse tumor-bearing leg. METHODS: The resonator had a multi-coil parallel-gap structure with a sample space of 16 mm in diameter and 20 mm in length. Microstrip line couplers were used in conjunction with varactor diodes to enable resonance frequency adjustment and to reduce the non-linear effects of the varactor diodes...
August 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28841546/transfer-learning-a-riemannian-geometry-framework-with-applications-to-brain-computer-interfaces
#20
Paolo Zanini, Marco Congedo, Christian Jutten, Salem Said, Yannick Berthoumieu
OBJECTIVE: This paper tackles the problem of transfer learning in the context of EEG-based Brain Computer Interface (BCI) classification. In particular the problems of cross-session and cross-subject classification are considered. These problems concern the ability to use data from previous sessions or from a database of past users to calibrate and initialize the classifier, allowing a calibration-less BCI mode of operation. METHODS: Data are represented using spatial covariance matrices of the EEG signals, exploiting the recent successful techniques based on the Riemannian geometry of the manifold of Symmetric Positive Definite (SPD) matrices...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
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