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IEEE Transactions on Bio-medical Engineering

Vahid Soleimani, Majid Mirmehdi, Dima Damen, Massimo Camplani, Sion Hannuna, Charles Sharp, James Dodd
OBJECTIVE: We propose a novel depth-based photoplethysmography (dPPG) approach to reduce motion artifacts in respiratory volume-time data and improve the accuracy of remote pulmonary function testing (PFT) measures. METHOD: Following spatial and temporal calibration of two opposing RGB-D sensors, a dynamic three-dimensional model of the subject performing PFT is reconstructed and used to decouple trunk movements from respiratory motions. Depth-based volume-time data is then retrieved, calibrated, and used to compute 11 clinical PFT measures for forced vital capacity and slow vital capacity spirometry tests...
June 2018: IEEE Transactions on Bio-medical Engineering
Shaojie Tang, Kuidong Huang, Yunyong Cheng, Tianye Niu, Xiangyang Tang
GOALS: With substantially increased number of detector rows in multidetector CT (MDCT), axial scan with projection data acquired along a circular source trajectory has become the method-of-choice in increasing clinical applications. Recognizing the practical relevance of image reconstruction directly from the projection data acquired in the native cone beam (CB) geometry, especially in scenarios wherein the most achievable in-plane resolution is desirable, we present a three-dimensional (3-D) weighted CB-FBP algorithm in such geometry in this paper...
June 2018: IEEE Transactions on Bio-medical Engineering
Hanguang Xiao, Mark Butlin, Ahmad Qasem, Isabella Tan, Decai Li, Alberto P Avolio
OBJECTIVE: N-point moving average (NPMA) is a simplified method of central aortic systolic pressure (CASP) estimation in comparison with the generalized transfer function (GTF). The fundamental difference or similarity between the methods is not established. This study investigates theoretical properties of NPMA relative to GTF and explores the integer and fractional denominator for the averaging process in the NPMA. METHODS: Convolution of a specified square wave and the radial (or brachial) blood pressure waveform constituted the NPMA ...
June 2018: IEEE Transactions on Bio-medical Engineering
Minpeng Xu, Xiaolin Xiao, Yijun Wang, Hongzhi Qi, Tzyy-Ping Jung, Dong Ming
GOAL: Traditional visual brain-computer interfaces (BCIs) preferred to use large-size stimuli to attract the user's attention and elicit distinct electroencephalography (EEG) features. However, the visual stimuli are of no interest to the users as they just serve as the hidden codes behind the characters. Furthermore, using stronger visual stimuli could cause visual fatigue and other adverse symptoms to users. Therefore, it's imperative for visual BCIs to use small and inconspicuous visual stimuli to code characters...
May 2018: IEEE Transactions on Bio-medical Engineering
Jiong Zhang, Erik Bekkers, Da Chen, Tos T J M Berendschot, Jan Schouten, Josien P W Pluim, Yonggang Shi, Behdad Dashtbozorg, Bart M Ter Haar Romeny
OBJECTIVE: In this paper, we propose a robust, efficient, and automatic reconnection algorithm for bridging interrupted curvilinear skeletons in ophthalmologic images. METHODS: This method employs the contour completion process, i.e., mathematical modeling of the direction process in the roto-translation group to achieve line propagation/completion. The completion process can be used to reconstruct interrupted curves by considering their local consistency. An explicit scheme with finite-difference approximation is used to construct the three-dimensional (3-D) completion kernel, where we choose the Gamma distribution for time integration...
May 2018: IEEE Transactions on Bio-medical Engineering
Houssem-Eddine Gueziri, Michael J McGuffin, Catherine Laporte
OBJECTIVE: During an interactive image segmentation task, the outcome is strongly influenced by human factors. In particular, a reduction in computation time does not guarantee an improvement in the overall segmentation time. This paper characterizes user efficiency during scribble-based interactive segmentation as a function of computation time. METHODS: We report a controlled experiment with users who experienced eight different levels of simulated latency (ranging from 100 to 2000 ms) with two techniques for refreshing visual feedback (either automatic, where the segmentation was recomputed and displayed continuously during label drawing, or user initiated, which was only computed and displayed each time the user hits a defined button)...
May 2018: IEEE Transactions on Bio-medical Engineering
Di Wu, Molly Donovan Wong, Kai Yang, Aimin Yan, Yuhua Li, Laurie Fajardo, Bin Zheng, Xizeng Wu, Hong Liu
The ability of microbubbles to benefit the imaging quality of high-energy in-line phase contrast as compared with conventional low-energy contact mode radiography was investigated. The study was conducted by comparing in-line phase contrast imaging with conventional contact-mode projection imaging under the same dose delivered to a phantom. A custom-designed phantom was employed to simulate a segment of human blood vessel injected with microbubble suspensions. The microbubbles were suspended in deionized water to obtain different volume concentrations...
May 2018: IEEE Transactions on Bio-medical Engineering
Magdy F Iskander, Todd B Seto, Ruthsenne Rg Perron, Eunjung Lim, Farhan Qazi
OBJECTIVE: The purpose of this study is to evaluate the accuracy of a noninvasive radiofrequency-based device, the Cardio-Pulmonary Stethoscope (CPS), to monitor heart and respiration rates, and detect changes in lung water content in human experiments and clinical trials. METHODS: Three human populations (healthy subjects ( ), heart failure (), and hemodialysis () patients) were enrolled in this study. The study was conducted at the University of Hawaii and the Queen's Medical Center in Honolulu, HI, USA...
May 2018: IEEE Transactions on Bio-medical Engineering
Zheng Zhang, Sean Rose, Jinghan Ye, Amy E Perkins, Buxin Chen, Chien-Min Kao, Emil Y Sidky, Chi-Hua Tung, Xiaochuan Pan
OBJECTIVE: We investigate an optimization-based approach to image reconstruction from list-mode data in digital time-of-flight (TOF) positron emission tomography (PET) imaging. METHOD: In the study, the image to be reconstructed is designed as a solution to a convex, non-smooth optimization program, and a primal-dual algorithm is developed for image reconstruction by solving the optimization program. The algorithm is first applied to list-mode TOF-PET data of a typical count level from physical phantoms and a human subject...
April 2018: IEEE Transactions on Bio-medical Engineering
Elena Bernardis, Yong Zhang, Ender Konukoglu, Yangming Ou, Harold S Javitz, Leon Axel, Dimitris Metaxas, Benoit Desjardins, Kilian M Pohl
OBJECTIVE: This paper presents a framework for temporal shape analysis to capture the shape and changes of anatomical structures from three-dimensional+t(ime) medical scans. METHOD: We first encode the shape of a structure at each time point with the spectral signature, i.e., the eigenvalues and eigenfunctions of the Laplace operator. We then expand it to capture morphing shapes by tracking the eigenmodes across time according to the similarity of their eigenfunctions...
April 2018: IEEE Transactions on Bio-medical Engineering
Alba Martin-Yebra, Violeta Monasterio, Iwona Cygankiewicz, Antoni Bayes-de-Luna, Enrico G Caiani, Pablo Laguna, Juan Pablo Martinez
OBJECTIVE: We proposed and evaluated a method for correcting possible phase shifts provoked by the presence of ventricular premature contractions (VPCs) for a better assessment of T-wave alternans (TWA).  Methods: First, we synthesized ECG signals with artificial TWA in the presence of different noise sources. Then, we assessed the prognostic value for sudden cardiac death (SCD) of the long-term average of TWA amplitude (the index of average alternans, ) in ambulatory ECG signals from congestive heart failure (CHF) and evaluated whether it is sensitive to the presence of VPCs...
March 2018: IEEE Transactions on Bio-medical Engineering
Mina Khoshdeli, Bahram Parvin
Detection of nuclei is an important step in phenotypic profiling of 1) histology sections imaged in bright field; and 2) colony formation of the 3-D cell culture models that are imaged using confocal microscopy. It is shown that feature-based representation of the original image improves color decomposition (CD) and subsequent nuclear detection using convolutional neural networks independent of the imaging modality. The feature-based representation utilizes the Laplacian of Gaussian (LoG) filter, which accentuates blob-shape objects...
March 2018: IEEE Transactions on Bio-medical Engineering
Da Woon Jung, Su Hwan Hwang, Jae Geol Cho, Byung Hun Choi, Hyun Jae Baek, Yu Jin Lee, Do-Un Jeong, Kwang Suk Park
OBJECTIVE: Nocturnal pulse oximetry has been proposed as a simpler alternative to polysomnography in diagnosing sleep apnea. However, existing techniques are limited in terms of inability to provide time information on sleep apnea occurrence. This study aimed to propose a new strategy for near real-time automatic detection of apneic events and reliable estimation of apnea-hypopnea index using nocturnal pulse oximetry. METHODS: Among 230 polysomnographic recordings with apnea-hypopnea index values ranging from 0 to 86...
March 2018: IEEE Transactions on Bio-medical Engineering
A Mason, O Korostynska, J Louis, L E Cordova-Lopez, B Abdullah, J Greene, R Connell, J Hopkins
GOAL: This paper reports a novel electromagnetic sensor technique for real-time noninvasive monitoring of blood lactate in human subjects. METHODS: The technique was demonstrated on 34 participants who undertook a cycling regime, with rest period before and after, to produce a rising and falling lactate response curve. Sensors attached to the arm and legs of participants gathered spectral data, blood samples were measured using a Lactate Pro V2; temperature and heart rate data was also collected...
March 2018: IEEE Transactions on Bio-medical Engineering
Bin Li, Ye Shi, Adam Fontecchio, Yon Visell
OBJECTIVE: The mechanical imaging of lumps in tissues via surface measurements can permit the noninvasive detection of disease-related differences in body tissues. We present and evaluate sensing techniques for the mechanical imaging of soft tissues, using a highly compliant electronic sensing array. METHODS: We developed a mechanical imaging system for capturing tissue properties during automatic- or human-guided palpation. It combines extremely compliant capacitive tactile sensors based on soft polymers and microfluidic electrodes with custom electronic data acquisition hardware, and new algorithms for enhanced tactile imaging by reference to nominal tissue responses...
March 2018: IEEE Transactions on Bio-medical Engineering
Wesley Johnson, Changsheng Dai, Jun Liu, Xian Wang, Devin K Luu, Zhuoran Zhang, Changhai Ru, Chao Zhou, Min Tan, Huayan Pu, Shaorong Xie, Yan Peng, Jun Luo, Yu Sun
Mammalian oocytes such as mouse oocytes have a highly elastic outer membrane, zona pellucida (ZP) that cannot be penetrated without significantly deforming the oocyte, even with a sharp micropipette. Piezo drill devices leverage lateral and axial vibration of the micropipette to accomplish ZP penetration with greatly reduced oocyte deformation. However, existing piezo drills all rely on a large lateral micropipette vibration amplitude ( 20 ) and a small axial vibration amplitude (0.1 ). The very large lateral vibration amplitude has been deemed to be necessary for ZP penetration although it also induces larger oocyte deformation and more oocyte damage...
March 2018: IEEE Transactions on Bio-medical Engineering
Rendong Chen, Tian'an Jiang, Fang Lu, Kaifeng Wang, Dexing Kong
Radiofrequency ablation (RFA) is currently one of the most effective methods for minimally invasive treatment of hepatic tumors. Planning the probe placements is an essential and challenging step in RFA treatment. To completely destroy the tumor with minimum amount of affected native tissue, a new RFA planning system is proposed in this paper. In the proposed planning system, the minimum number of ablations and a conical insertion region for each ablation session are determined automatically. Based on the geometric character of the tumor, a novel clustering algorithm is developed to allow a better layout of the overlapping ablations...
March 2018: IEEE Transactions on Bio-medical Engineering
Faizan Javed, Henrik Fox, Jeffery Armitstead
OBJECTIVE: Cheyne-Stokes respiration (CSR) related features are significantly associated with cardiac dysfunction. Scoring of these features is labor intensive and time-consuming. To automate the scoring process, an algorithm (ResCSRF) has been developed to extract these features from nocturnal measurement of respiratory signals. METHODS: ResCSRF takes four signals (nasal flow, thorax, abdomen, and finger oxygen saturation) as input. It first detects CSR cycles and then calculates the respiratory features (cycle length, lung-to-periphery circulation time, and time to peak flow)...
March 2018: IEEE Transactions on Bio-medical Engineering
Kiran Kumar Sriperumbudur, Hans Wilhelm Pau, Ursula van Rienen
Electric stimulation of the auditory nerve by cochlear implants has been a successful clinical intervention to treat the sensory neural deafness. In this pathological condition of the cochlea, type-1 spiral ganglion neurons in Rosenthal's canal play a vital role in the action potential initiation. Various morphological studies of the human temporal bones suggest that the spiral ganglion neurons are surrounded by heterogeneous structures formed by a variety of cells and tissues. However, the existing simulation models have not considered the tissue heterogeneity in the Rosenthal's canal while studying the electric field interaction with spiral ganglion neurons...
March 2018: IEEE Transactions on Bio-medical Engineering
Sudeshna Sil Kar, Santi P Maity
OBJECTIVE: Diabetic retinopathy (DR) is characterized by the progressive deterioration of retina with the appearance of different types of lesions that include microaneurysms, hemorrhages, exudates, etc. Detection of these lesions plays a significant role for early diagnosis of DR. METHODS: To this aim, this paper proposes a novel and automated lesion detection scheme, which consists of the four main steps: vessel extraction and optic disc removal, preprocessing, candidate lesion detection, and postprocessing...
March 2018: IEEE Transactions on Bio-medical Engineering
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