Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner
SUMMARYDeazaguanine modifications play multifaceted roles in the molecular biology of DNA and tRNA, shaping diverse yet essential biological processes, including the nuanced fine-tuning of translation efficiency and the intricate modulation of codon-anticodon interactions. Beyond their roles in translation, deazaguanine modifications contribute to cellular stress resistance, self-nonself discrimination mechanisms, and host evasion defenses, directly modulating the adaptability of living organisms. Deazaguanine moieties extend beyond nucleic acid modifications, manifesting in the structural diversity of biologically active natural products...
February 29, 2024: Microbiology and Molecular Biology Reviews: MMBR