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Nature Reviews. Microbiology

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https://www.readbyqxmd.com/read/30237491/exporting-electrons
#1
Andrea Du Toit
No abstract text is available yet for this article.
September 20, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30214022/hiv-1-s-fingerprint
#2
Ursula Hofer
No abstract text is available yet for this article.
September 13, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30206344/author-correction-anti-trypanosomatid-drug-discovery-an-ongoing-challenge-and-a-continuing-need
#3
Mark C Field, David Horn, Alan H Fairlamb, Michael A J Ferguson, David W Gray, Kevin D Read, Manu De Rycker, Leah S Torrie, Paul G Wyatt, Susan Wyllie, Ian H Gilbert
The structures of nifurtimox in Table 1 were incorrect and have been updated in the pdf and online. The authors apologize for any confusion caused.
September 11, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30194403/the-birth-evolution-and-death-of-metabolic-gene-clusters-in-fungi
#4
REVIEW
Antonis Rokas, Jennifer H Wisecaver, Abigail L Lind
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways involved in ecologically specialized or accessory functions. Genes in these pathways are frequently physically linked on fungal chromosomes, forming metabolic gene clusters (MGCs). In this Review, we describe the diversity in the structure and content of fungal MGCs, their population-level and species-level variation, the evolutionary mechanisms that underlie their formation, maintenance and decay, and their ecological and evolutionary impact on fungal populations...
September 7, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30181663/biosynthetic-capacity-metabolic-variety-and-unusual-biology-in-the-cpr-and-dpann-radiations
#5
Cindy J Castelle, Christopher T Brown, Karthik Anantharaman, Alexander J Probst, Raven H Huang, Jillian F Banfield
Candidate phyla radiation (CPR) bacteria and DPANN (an acronym of the names of the first included phyla) archaea are massive radiations of organisms that are widely distributed across Earth's environments, yet we know little about them. Initial indications are that they are consistently distinct from essentially all other bacteria and archaea owing to their small cell and genome sizes, limited metabolic capacities and often episymbiotic associations with other bacteria and archaea. In this Analysis, we investigate their biology and variations in metabolic capacities by analysis of approximately 1,000 genomes reconstructed from several metagenomics-based studies...
September 4, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30177800/next-generation-bacterial-taxonomy
#6
Ashley York
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30177799/slipping-through-the-net
#7
Ashley York
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30177798/pick-of-the-crop-microbiome
#8
Ashley York
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30177797/channeling-the-vacuole
#9
Ashley York
No abstract text is available yet for this article.
September 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30171202/molecular-mechanisms-of-crispr-cas-spacer-acquisition
#10
REVIEW
Jon McGinn, Luciano A Marraffini
Many bacteria and archaea have the unique ability to heritably alter their genomes by incorporating small fragments of foreign DNA, called spacers, into CRISPR loci. Once transcribed and processed into individual CRISPR RNAs, spacer sequences guide Cas effector nucleases to destroy complementary, invading nucleic acids. Collectively, these two processes are known as the CRISPR-Cas immune response. In this Progress article, we review recent studies that have advanced our understanding of the molecular mechanisms underlying spacer acquisition and that have revealed a fundamental link between the two phases of CRISPR immunity that ensures optimal immunity from newly acquired spacers...
August 31, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30166595/maximizing-delivery
#11
Andrea Du Toit
No abstract text is available yet for this article.
August 30, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30143749/molecular-mechanisms-of-viral-oncogenesis-in-humans
#12
REVIEW
Nathan A Krump, Jianxin You
Viral infection is a major contributor to the global cancer burden. Recent advances have revealed that seven known oncogenic viruses promote tumorigenesis through shared host cell targets and pathways. A comprehensive understanding of the principles of viral oncogenesis may enable the identification of unknown infectious aetiologies of cancer and the development of therapeutic or preventive strategies for virus-associated cancers. In this Review, we discuss the molecular mechanisms of viral oncogenesis in humans...
August 24, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30127345/microbiology-of-the-built-environment
#13
REVIEW
Jack A Gilbert, Brent Stephens
The built environment comprises all structures built by humans, including our homes, workplaces, schools and vehicles. As in any ecosystem on Earth, microorganisms have been found in every part of the built environment that has been studied. They exist in the air, on surfaces and on building materials, usually dispersed by humans, animals and outdoor sources. Those microbial communities and their metabolites have been implied to cause (or exacerbate) and prevent (or mitigate) human disease. In this Review, we outline the history of the field of microbiology of the built environment and discuss recent insights that have been gained into microbial ecology, adaptation and evolution of this ecosystem...
August 20, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30104690/targeting-mechanisms-of-tailed-bacteriophages
#14
REVIEW
Franklin L Nobrega, Marnix Vlot, Patrick A de Jonge, Lisa L Dreesens, Hubertus J E Beaumont, Rob Lavigne, Bas E Dutilh, Stan J J Brouns
Phages differ substantially in the bacterial hosts that they infect. Their host range is determined by the specific structures that they use to target bacterial cells. Tailed phages use a broad range of receptor-binding proteins, such as tail fibres, tail spikes and the central tail spike, to target their cognate bacterial cell surface receptors. Recent technical advances and new structure-function insights have begun to unravel the molecular mechanisms and temporal dynamics that govern these interactions. Here, we review the current understanding of the targeting machinery and mechanisms of tailed phages...
August 13, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30097647/archaeal-biofilm-formation
#15
REVIEW
Marleen van Wolferen, Alvaro Orell, Sonja-Verena Albers
Biofilms are structured and organized communities of microorganisms that represent one of the most successful forms of life on Earth. Bacterial biofilms have been studied in great detail, and many molecular details are known about the processes that govern bacterial biofilm formation, however, archaea are ubiquitous in almost all habitats on Earth and can also form biofilms. In recent years, insights have been gained into the development of archaeal biofilms, how archaea communicate to form biofilms and how the switch from a free-living lifestyle to a sessile lifestyle is regulated...
August 10, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30076406/taking-control-over-the-host
#16
Andrea Du Toit
No abstract text is available yet for this article.
August 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30076405/layers-of-complexity-in-the-ground
#17
Andrea Du Toit
No abstract text is available yet for this article.
August 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30076404/defending-the-niche
#18
Andrea Du Toit
No abstract text is available yet for this article.
August 3, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30008469/structural-insights-into-the-signalling-mechanisms-of-two-component-systems
#19
REVIEW
Fran├žoise Jacob-Dubuisson, Ariel Mechaly, Jean-Michel Betton, Rudy Antoine
Two-component systems reprogramme diverse aspects of microbial physiology in response to environmental cues. Canonical systems are composed of a transmembrane sensor histidine kinase and its cognate response regulator. They catalyse three reactions: autophosphorylation of the histidine kinase, transfer of the phosphoryl group to the regulator and dephosphorylation of the phosphoregulator. Elucidating signal transduction between sensor and output domains is highly challenging given the size, flexibility and dynamics of histidine kinases...
July 15, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/30008468/bacterial-adhesion-at-the-single-cell-level
#20
REVIEW
Cecile Berne, Courtney K Ellison, Adrien Ducret, Yves V Brun
The formation of multicellular microbial communities, called biofilms, starts from the adhesion of a few planktonic cells to the surface. The transition from a free-living planktonic lifestyle to a sessile, attached state is a multifactorial process that is determined by biological, chemical and physical properties of the environment, the surface and the bacterial cell. The initial weak, reversible interactions between a bacterium and a surface strengthen to yield irreversible adhesion. In this Review, we summarize our understanding of the mechanisms governing bacterial adhesion at the single-cell level, including the physical forces experienced by a cell before reaching the surface, the first contact with a surface and the transition from reversible to permanent adhesion...
July 15, 2018: Nature Reviews. Microbiology
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