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Nature Reviews. Microbiology

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https://www.readbyqxmd.com/read/28736449/interbacterial-predation-as-a-strategy-for-dna-acquisition-in-naturally-competent-bacteria
#1
Jan-Willem Veening, Melanie Blokesch
This corrects the article DOI: 10.1038/nrmicro.2017.66.
July 24, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28736448/antimalarial-drug-discovery-approaches-and-progress-towards-new-medicines
#2
Erika L Flannery, Arnab K Chatterjee, Elizabeth A Winzeler
No abstract text is available yet for this article.
July 24, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28736447/prokaryotic-argonaute-proteins-novel-genome-editing-tools
#3
REVIEW
Jorrit W Hegge, Daan C Swarts, John van der Oost
Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
July 24, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28736446/viral-infection-when-two-become-one
#4
Ashley York
No abstract text is available yet for this article.
July 24, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28713154/legionella-and-coxiella-effectors-strength-in-diversity-and-activity
#5
REVIEW
Jiazhang Qiu, Zhao-Qing Luo
Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host cells. These effectors are essential for the establishment of membrane-bound compartments known as replication vacuoles, which enable the survival and replication of bacteria inside host cells. The effectors interfere with diverse signalling pathways to co-opt host processes, such as vesicle trafficking, ubiquitylation, gene expression and lipid metabolism, to promote pathogen survival...
July 17, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28690319/interbacterial-predation-as-a-strategy-for-dna-acquisition-in-naturally-competent-bacteria
#6
REVIEW
Jan-Willem Veening, Melanie Blokesch
Natural competence enables bacteria to take up exogenous DNA. The evolutionary function of natural competence remains controversial, as imported DNA can act as a source of substrates or can be integrated into the genome. Exogenous homologous DNA can also be used for genome repair. In this Opinion article, we propose that predation of non-related neighbouring bacteria coupled with competence regulation might function as an active strategy for DNA acquisition. Competence-dependent kin-discriminated killing has been observed in the unrelated bacteria Vibrio cholerae and Streptococcus pneumoniae...
July 10, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28649138/pseudomonas-predators-understanding-and-exploiting-phage-host-interactions
#7
REVIEW
Jeroen De Smet, Hanne Hendrix, Bob G Blasdel, Katarzyna Danis-Wlodarczyk, Rob Lavigne
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant pathogen Pseudomonas syringae. The bacteriophages that infect Pseudomonas spp. mirror the widespread and diverse nature of their hosts. Therefore, Pseudomonas spp. and their phages are an ideal system to study the molecular mechanisms that govern virus-host interactions. Furthermore, phages are principal catalysts of host evolution and diversity, which directly affects the ecological roles of environmental and pathogenic Pseudomonas spp...
June 26, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28649136/viral-effects-on-the-content-and-function-of-extracellular-vesicles
#8
REVIEW
Nancy Raab-Traub, Dirk P Dittmer
The release of membrane-bound vesicles from cells is being increasingly recognized as a mechanism of intercellular communication. Extracellular vesicles (EVs) or exosomes are produced by virus-infected cells and are thought to be involved in intercellular communication between infected and uninfected cells. Viruses, in particular oncogenic viruses and viruses that establish chronic infections, have been shown to modulate the production and content of EVs. Viral microRNAs, proteins and even entire virions can be incorporated into EVs, which can affect the immune recognition of viruses or modulate neighbouring cells...
June 26, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28626231/the-resilience-of-the-intestinal-microbiota-influences-health-and-disease
#9
REVIEW
Felix Sommer, Jacqueline Moltzau Anderson, Richa Bharti, Jeroen Raes, Philip Rosenstiel
The composition of the intestinal microbiota varies among individuals and throughout development, and is dependent on host and environmental factors. However, although the microbiota is constantly exposed to environmental challenges, its composition and function in an individual are stable against perturbations, as microbial communities are resilient and resistant to change. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and also between the microorganisms and the intestinal interface of the host...
June 19, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28626230/engineering-of-obligate-intracellular-bacteria-progress-challenges-and-paradigms
#10
REVIEW
Erin E McClure, Adela S Oliva Chávez, Dana K Shaw, Jason A Carlyon, Roman R Ganta, Susan M Noh, David O Wood, Patrik M Bavoil, Kelly A Brayton, Juan J Martinez, Jere W McBride, Raphael H Valdivia, Ulrike G Munderloh, Joao H F Pedra
It is estimated that approximately one billion people are at risk of infection with obligate intracellular bacteria, but little is known about the underlying mechanisms that govern their life cycles. The difficulty in studying Chlamydia spp., Coxiella spp., Rickettsia spp., Anaplasma spp., Ehrlichia spp. and Orientia spp. is, in part, due to their genetic intractability. Recently, genetic tools have been developed; however, optimizing the genomic manipulation of obligate intracellular bacteria remains challenging...
June 19, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28603278/transmission-of-the-gut-microbiota-spreading-of-health
#11
REVIEW
Hilary P Browne, B Anne Neville, Samuel C Forster, Trevor D Lawley
Transmission of commensal intestinal bacteria between humans could promote health by establishing, maintaining and replenishing microbial diversity in the microbiota of an individual. Unlike pathogens, the routes of transmission for commensal bacteria remain unappreciated and poorly understood, despite the likely commonalities between both. Consequently, broad infection control measures that are designed to prevent pathogen transmission and infection, such as oversanitation and the overuse of antibiotics, may inadvertently affect human health by altering normal commensal transmission...
June 12, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28690322/viral-infection-packing-to-leave
#12
Ashley York
No abstract text is available yet for this article.
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28690321/adaptation-that-s-what-you-need
#13
Chrispin Chaguza, Stephen D Bentley
No abstract text is available yet for this article.
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28690320/structural-biology-cascade-keeps-its-targets-in-the-loop
#14
Andrea Du Toit
No abstract text is available yet for this article.
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28669981/antimicrobials-modified-sugar-compound-can-clear-intestinal-colonization-by-upec
#15
Irene Vacca
No abstract text is available yet for this article.
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28649137/bacterial-secretion-shigella-sonnei-has-the-edge
#16
Shimona Starling
No abstract text is available yet for this article.
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28603279/variant-surface-antigens-of-plasmodium-falciparum-and-their-roles-in-severe-malaria
#17
REVIEW
Mats Wahlgren, Suchi Goel, Reetesh R Akhouri
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of infected erythrocytes; for example, to import nutrients and to bind to other erythrocytes and the host microvasculature. Binding is mediated by the adhesive polypeptides Plasmodium falciparum-encoded repetitive interspersed families of polypeptides (RIFINs), subtelomeric variant open reading frame (STEVOR) and P. falciparum erythrocyte membrane protein 1 (PfEMP1), which are encoded by multigene families to ensure antigenic variation and evasion of host immunity...
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28555073/pathways-to-zoonotic-spillover
#18
REVIEW
Raina K Plowright, Colin R Parrish, Hamish McCallum, Peter J Hudson, Albert I Ko, Andrea L Graham, James O Lloyd-Smith
Zoonotic spillover, which is the transmission of a pathogen from a vertebrate animal to a human, presents a global public health burden but is a poorly understood phenomenon. Zoonotic spillover requires several factors to align, including the ecological, epidemiological and behavioural determinants of pathogen exposure, and the within-human factors that affect susceptibility to infection. In this Opinion article, we propose a synthetic framework for animal-to-human transmission that integrates the relevant mechanisms...
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28529326/persistent-bacterial-infections-and-persister-cells
#19
REVIEW
Robert A Fisher, Bridget Gollan, Sophie Helaine
Many bacteria can infect and persist inside their hosts for long periods of time. This can be due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective killing by antibiotics. Bacteria can survive antibiotic treatment if they are resistant or tolerant to a drug. Persisters are a subpopulation of transiently antibiotic-tolerant bacterial cells that are often slow-growing or growth-arrested, and are able to resume growth after a lethal stress. The formation of persister cells establishes phenotypic heterogeneity within a bacterial population and has been hypothesized to be important for increasing the chances of successfully adapting to environmental change...
August 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28529325/anticancer-effects-of-the-microbiome-and-its-products
#20
REVIEW
Laurence Zitvogel, Romain Daillère, María Paula Roberti, Bertrand Routy, Guido Kroemer
The human gut microbiome modulates many host processes, including metabolism, inflammation, and immune and cellular responses. It is becoming increasingly apparent that the microbiome can also influence the development of cancer. In preclinical models, the host response to cancer treatment has been improved by modulating the gut microbiome; this is known to have an altered composition in many diseases, including cancer. In addition, cancer treatment with microbial agents or their products has the potential to shrink tumours...
August 2017: Nature Reviews. Microbiology
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