Yao Zhang, Xu Wu, Dan Li, Rong Huang, Xiangyu Deng, Mingxing Li, Fukuan Du, Yueshui Zhao, Jing Shen, Yu Chen, Pingxiu Zhang, Congcui Hu, Zhangang Xiao, Qinglian Wen
BACKGROUND: Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively...
March 22, 2024: BMC Microbiology