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BMC Microbiology

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https://www.readbyqxmd.com/read/28720084/sequence-based-identification-of-inositol-monophosphatase-like-histidinol-phosphate-phosphatases-hisn-in-corynebacterium-glutamicum-actinobacteria-and-beyond
#1
Robert Kasimir Kulis-Horn, Christian Rückert, Jörn Kalinowski, Marcus Persicke
BACKGROUND: The eighth step of L-histidine biosynthesis is carried out by an enzyme called histidinol-phosphate phosphatase (HolPase). Three unrelated HolPase families are known so far. Two of them are well studied: HAD-type HolPases known from Gammaproteobacteria like Escherichia coli or Salmonella enterica and PHP-type HolPases known from yeast and Firmicutes like Bacillus subtilis. However, the third family of HolPases, the inositol monophosphatase (IMPase)-like HolPases, present in Actinobacteria like Corynebacterium glutamicum (HisN) and plants, are poorly characterized...
July 18, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28716079/the-human-jejunum-has-an-endogenous-microbiota-that-differs-from-those-in-the-oral-cavity-and-colon
#2
Olof H Sundin, Antonio Mendoza-Ladd, Mingtao Zeng, Diana Diaz-Arévalo, Elisa Morales, B Matthew Fagan, Javier Ordoñez, Philip Velez, Nishaal Antony, Richard W McCallum
BACKGROUND: The upper half of the human small intestine, known as the jejunum, is the primary site for absorption of nutrient-derived carbohydrates, amino acids, small peptides, and vitamins. In contrast to the colon, which contains 10(11)-10(12) colony forming units of bacteria per ml (CFU/ml), the normal jejunum generally ranges from 10(3) to 10(5) CFU per ml. Because invasive procedures are required to access the jejunum, much less is known about its bacterial microbiota. Bacteria inhabiting the jejunal lumen have been investigated by classical culture techniques, but not by culture-independent metagenomics...
July 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28709400/broad-range-potential-of-asphodelus-microcarpus-leaves-extract-for-drug-development
#3
Amalia Di Petrillo, Antonella Fais, Francesca Pintus, Celestino Santos-Buelga, Ana M González-Paramás, Vincenzo Piras, Germano Orrù, Antonello Mameli, Enzo Tramontano, Aldo Frau
BACKGROUND: Many plants have been used in traditional medicine for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, anti-inflammatory and anticancer activities. In order to find novel antimicrobial and antiviral agents, the aim of the present study was the evaluation of the antibacterial and antibiofilm susceptibility of Asphodelus microcarpus leaves extract. Moreover, the antiviral activity and the phytochemical composition of the active extract were also determined...
July 14, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28701186/the-oral-fungal-mycobiome-characteristics-and-relation-to-periodontitis-in-a-pilot-study
#4
Brandilyn A Peters, Jing Wu, Richard B Hayes, Jiyoung Ahn
BACKGROUND: The oral fungal microbiome (mycobiome) is not well characterized, particularly in relation to oral diseases such as periodontal disease. We aimed to describe and compare the oral mycobiome of subjects with and without periodontal disease. RESULTS: We characterized the oral mycobiome in 30 adult subjects (15 with periodontal disease, 15 with good oral health) by sequencing the taxonomically informative pan-fungal internal transcribed spacer (ITS) gene in DNA extracted from oral wash samples...
July 12, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28701150/physiological-roles-of-sigma-factor-sigd-in-corynebacterium-glutamicum
#5
Hironori Taniguchi, Tobias Busche, Thomas Patschkowski, Karsten Niehaus, Miroslav Pátek, Jörn Kalinowski, Volker F Wendisch
BACKGROUND: Sigma factors are one of the components of RNA polymerase holoenzymes, and an essential factor of transcription initiation in bacteria. Corynebacterium glutamicum possesses seven genes coding for sigma factors, most of which have been studied to some detail; however, the role of SigD in transcriptional regulation in C. glutamicum has been mostly unknown. RESULTS: In this work, pleiotropic effects of sigD overexpression at the level of phenotype, transcripts, proteins and metabolites were investigated...
July 12, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28693424/bacillus-subtilis-iolq-dega-is-a-transcriptional-repressor-of-iolx-encoding-nad-dependent-scyllo-inositol-dehydrogenase
#6
Dong-Min Kang, Christophe Michon, Tetsuro Morinaga, Kosei Tanaka, Shinji Takenaka, Shu Ishikawa, Ken-Ichi Yoshida
BACKGROUND: Bacillus subtilis is able to utilize at least three inositol stereoisomers as carbon sources, myo-, scyllo-, and D-chiro-inositol (MI, SI, and DCI, respectively). NAD(+)-dependent SI dehydrogenase responsible for SI catabolism is encoded by iolX. Even in the absence of functional iolX, the presence of SI or MI in the growth medium was found to induce the transcription of iolX through an unknown mechanism. RESULTS: Immediately upstream of iolX, there is an operon that encodes two genes, yisR and iolQ (formerly known as degA), each of which could encode a transcriptional regulator...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28693414/hypothetical-protein-cpn0423-triggers-nod2-activation-and-contributes-to-chlamydia-pneumoniae-mediated-inflammation
#7
Hong-Liang Chen, Guo-Zhi Dai, An-Wen Zhou, Ran-Hui Li, Hong-Xia Yuan, Jing Xiang, Xiao-Xing You, Ou Ran, Yi-Mou Wu
BACKGROUND: Chlamydia pneumoniae (C. pneumoniae) is pathogenic to humans, by causing pulmonary inflammation or bronchitis in both adolescents and young adults. However, the molecular signals linking C. pneumoniae components to inflammation remain elusive. This study was to investigate the effect of Chlamydia-specific Cpn0423 of C. pneumoniae on C. pneumoniae-mediated inflammation. RESULTS: Cpn0423 was detected outside of C. pneumoniae inclusions, which induced production of several cytokines including macrophage inflammatory protein-2 (MIP-2) and interleukins (ILs)...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28693413/transcriptome-profiling-analysis-reveals-metabolic-changes-across-various-growth-phases-in-bacillus-pumilus-ba06
#8
Lin-Li Han, Huan-Huan Shao, Yong-Cheng Liu, Gang Liu, Chao-Ying Xie, Xiao-Jie Cheng, Hai-Yan Wang, Xue-Mei Tan, Hong Feng
BACKGROUND: Bacillus pumilus can secret abundant extracellular enzymes, and may be used as a potential host for the industrial production of enzymes. It is necessary to understand the metabolic processes during cellular growth. Here, an RNA-seq based transcriptome analysis was applied to examine B. pumilus BA06 across various growth stages to reveal metabolic changes under two conditions. RESULTS: Based on the gene expression levels, changes to metabolism pathways that were specific to various growth phases were enriched by KEGG analysis...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28693412/proteomics-based-identification-of-differentially-abundant-proteins-reveals-adaptation-mechanisms-of-xanthomonas-citri-subsp-citri-during-citrus-sinensis-infection
#9
Leandro M Moreira, Márcia R Soares, Agda P Facincani, Cristiano B Ferreira, Rafael M Ferreira, Maria I T Ferro, Fábio C Gozzo, Érica B Felestrino, Renata A B Assis, Camila Carrião M Garcia, João C Setubal, Jesus A Ferro, Julio C F de Oliveira
BACKGROUND: Xanthomonas citri subsp. citri (Xac) is the causal agent of citrus canker. A proteomic analysis under in planta infectious and non-infectious conditions was conducted in order to increase our knowledge about the adaptive process of Xac during infection. RESULTS: For that, a 2D-based proteomic analysis of Xac at 1, 3 and 5 days after inoculation, in comparison to Xac growth in NB media was carried out and followed by MALDI-TOF-TOF identification of 124 unique differentially abundant proteins...
July 11, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28676106/comparative-analysis-of-gut-microbiota-associated-with-body-mass-index-in-a-large-korean-cohort
#10
Yeojun Yun, Han-Na Kim, Song E Kim, Seong Gu Heo, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung-Lae Kim
BACKGROUND: Gut microbiota plays an important role in the harvesting, storage, and expenditure of energy obtained from one's diet. Our cross-sectional study aimed to identify differences in gut microbiota according to body mass index (BMI) in a Korean population. 16S rRNA gene sequence data from 1463 subjects were categorized by BMI into normal, overweight, and obese groups. Fecal microbiotas were compared to determine differences in diversity and functional inference analysis related with BMI...
July 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28676041/erratum-to-genome-wide-analysis-of-an-avirulent-strain-that-induces-protective-immunity-against-challenge-with-virulent-streptococcus-suis-serotype-2
#11
Jing Wang, Youjun Feng, Changjun Wang, Feng Zheng, Bachar Hassan, Liming Zhi, Wenjuan Li, Yi Yao, Elaine He, Shibo Jiang, Jiaqi Tang
No abstract text is available yet for this article.
July 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28676033/the-effects-of-probiotic-bacillus-subtilis-on-the-cytotoxicity-of-clostridium-perfringens-type-a-in-caco-2-cell-culture
#12
Maryam Poormontaseri, Saeid Hosseinzadeh, Seyed Shahram Shekarforoush, Tahereh Kalantari
BACKGROUND: Some Bacillus strains have recently been identified for potential use as probiotics and food additives. The present study evaluated the antimicrobial effects of Bacillus subtilis ATCC 6633 and its metabolite on the enterotoxin and vegetative cells, spore and germinated spore of Clostridium perfringens type A in Caco-2 cells. RESULTS: We used flow cytometry and MTT assays to evaluate the cytotoxicity effect of treatments. According to the results, the most cell survival was found in the 4% crude antimicrobial substance (CAS) with the vegetative form of C...
July 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28673241/effects-of-melanin-from-sepiella-maindroni-ink-msmi-on-the-intestinal-microbiome-of-mice
#13
Hui Dong, Weiwei Song, Chunlin Wang, Changkao Mu, Ronghua Li
BACKGROUND: By the search for new natural compounds with beneficial health effects, cephalopod ink has been considered as an attempt to develop new drugs and functional foods, which is an especially active field in Asia, where cephalopods are a major fishery catch, for which ink sacs are a bi-product and where homeopathic medicine has deep roots. There is a demand to evaluate the safety and influence to the organism. The specific composition and relative abundance of the gut microbiota, which is potentially a major modulator of host metabolism, drives the interaction between functional foods and host health...
July 3, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28673237/contribution-of-pilus-type-2b-to-invasive-disease-caused-by-a-streptococcus-agalactiae-st-17-strain
#14
Maddalena Lazzarin, Rong Mu, Monica Fabbrini, Claudia Ghezzo, C Daniela Rinaudo, Kelly S Doran, Immaculada Margarit
BACKGROUND: Group B Streptococcus (GBS) is a major cause of invasive disease especially in neonates. In GBS three structurally distinct pilus polymers have been identified as important virulence factors and promising vaccine candidates. The vast majority of Group B Streptococci belonging to the hypervirulent serotype III ST-17 lineage bear pilus types 1 and 2b. The purpose of this study was to investigate the relative contribution of these two pilus types to the pathogenesis of a ST-17 strain...
July 3, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28673236/erratum-to-comparative-genomics-and-evolution-of-the-amylase-binding-proteins-of-oral-streptococci
#15
Elaine M Haase, Yurong Kou, Amarpreet Sabharwal, Yu-Chieh Liao, Tianying Lan, Charlotte Lindqvist, Frank A Scannapieco
No abstract text is available yet for this article.
July 3, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28666415/soluble-factors-from-biofilm-of-candida-albicans-and-staphylococcus-aureus-promote-cell-death-and-inflammatory-response
#16
Kassia de Carvalho Dias, Paula Aboud Barbugli, Fernanda de Patto, Virginia Barreto Lordello, Letícia de Aquino Penteado, Alexandra Ivo Medeiros, Carlos Eduardo Vergani
BACKGROUND: The objective of this study was to better understand the effects of soluble factors from biofilm of single- and mixed-species Candida albicans (C. albicans) and methicillin-sensitive Staphylococcus aureus (MSSA) cultures after 36 h in culture on keratinocytes (NOK-si and HaCaT) and macrophages (J774A.1). Soluble factors from biofilms of C. albicans and MSSA were collected and incubated with keratinocytes and macrophages, which were subsequently evaluated by cell viability assays (MTT)...
June 30, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28662640/community-analysis-of-biofilms-on-flame-oxidized-stainless-steel-anodes-in-microbial-fuel-cells-fed-with-different-substrates
#17
Nweze Julius Eyiuche, Shiho Asakawa, Takahiro Yamashita, Atsuo Ikeguchi, Yutaka Kitamura, Hiroshi Yokoyama
BACKGROUND: The flame-oxidized stainless steel anode (FO-SSA) is a newly developed electrode that enhances microbial fuel cell (MFC) power generation; however, substrate preference and community structure of the biofilm developed on FO-SSA have not been well characterized. Herein, we investigated the community on FO-SSA using high-throughput sequencing of the 16S rRNA gene fragment in acetate-, starch-, glucose-, and livestock wastewater-fed MFCs. Furthermore, to analyze the effect of the anode material, the acetate-fed community formed on a common carbon-based electrode-carbon-cloth anode (CCA)-was examined for comparison...
June 29, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28659164/antioxidant-properties-antimicrobial-and-anti-adhesive-activities-of-dcs1-lipopeptides-from-bacillus-methylotrophicus-dcs1
#18
Nawel Jemil, Hanen Ben Ayed, Angeles Manresa, Moncef Nasri, Noomen Hmidet
BACKGROUND: The present work aims to investigate the antioxidant and antimicrobial activities as well as the potential of DCS1 lipopeptides produced by Bacillus methylotrophicus DCS1 strain at inhibition and disruption of biofilm formation. RESULTS: The produced biosurfactants were characterized as lipopeptides molecules by using thin layer chromatography (TLC) and Fourier transform infrared spectroscopy (FT-IR). The DCS1 lipopeptides were assayed for their antioxidant activity through five different tests...
June 28, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28655353/xc_0531-encodes-a-c-type-cytochrome-biogenesis-protein-and-is-required-for-pathogenesis-in-xanthomonas-campestris-pv-campestris
#19
Lei Chen, Mingpeng Wang, Li Huang, Zhaojie Zhang, Fanghua Liu, Guangtao Lu
BACKGROUND: The phytopathogenic Xanthomonas campestris pv.campestris is a gram-negative bacterium and the causal agent of black-rot disease of cruciferous crops. Many gram-negative bacteria possess a family of proteins, called Dsbs, which are involved in disulfide bond formation in certain periplasmic proteins. In our preliminary screening of the virulence to the plants we identified that gene XC_0531 which annotated gene dsbD of Xanthomonas campestris pv. campestris (Xcc) is related to the virulence to the host plants...
June 27, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28655338/tapping-the-biotechnological-potential-of-insect-microbial-symbionts-new-insecticidal-porphyrins
#20
Ana Flávia Canovas Martinez, Luís Gustavo de Almeida, Luiz Alberto Beraldo Moraes, Fernando Luís Cônsoli
BACKGROUND: The demand for sustainable agricultural practices and the limited progress toward newer and safer chemicals for use in pest control maintain the impetus for research and identification of new natural molecules. Natural molecules are preferable to synthetic organic molecules because they are biodegradable, have low toxicity, are often selective and can be applied at low concentrations. Microbes are one source of natural insecticides, and microbial insect symbionts have attracted attention as a source of new bioactive molecules because these microbes are exposed to various selection pressures in their association with insects...
June 27, 2017: BMC Microbiology
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