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https://www.readbyqxmd.com/read/28700537/quantitative-sensory-testing-response-patterns-to-capsaicin-and-ultraviolet-b-induced-local-skin-hypersensitization-in-healthy-subjects-a-machine-learned-analysis
#1
Jörn Lötsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch, Bruno G Oertel, Alfred Ultsch
The comprehensive assessment of pain-related human phenotypes requires combinations of nociceptive measures that produce complex high-dimensional data, posing challenges to bioinformatic analysis. In this study, we assessed established experimental models of heat hyperalgesia of the skin, consisting of local ultraviolet-B (UV-B) irradiation or capsaicin application, in 82 healthy subjects using a variety of noxious stimuli. We extended the original heat stimulation by applying cold and mechanical stimuli and assessing the hypersensitization effects with a clinically established quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain)...
August 9, 2017: Pain
https://www.readbyqxmd.com/read/28796118/emotional-awareness-and-expression-therapy-cognitive-behavioral-therapy-and-education-for-fibromyalgia-a-cluster-randomized-controlled-trial
#2
Mark A Lumley, Howard Schubiner, Nancy A Lockhart, Kelley M Kidwell, Steven E Harte, Daniel J Clauw, David A Williams
Patients with FM experience increased lifetime levels of psychosocial adversity, trauma, and emotional conflict. To address these risk factors, we developed Emotion Awareness and Expression Therapy (EAET) and tested its benefits against an active control condition, FM Education, and against the field's gold standard intervention for FM, cognitive-behavioral therapy (CBT) for symptom management. Adults with FM (n = 230) formed 40 treatment groups, which were randomized to EAET, CBT, or Education and given eight, 90-min sessions...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28796117/spouse-criticism-and-hostility-during-marital-interaction-effects-on-pain-intensity-and-behaviors-among-individuals-with-chronic-low-back-pain
#3
John W Burns, Kristina M Post, David A Smith, Laura S Porter, Asokumar Buvanendran, Anne Marie Fras, Francis J Keefe
Individuals with chronic pain may experience negative responses from spouse, family and friends. Responses such as overt criticism and hostility may be associated with worsening pain and function for chronic pain sufferers. We used a laboratory procedure to evaluate whether variability in spouse criticism/hostility exhibited toward chronic low back pain (CLBP) patients during a conflictual discussion predicted variability in patient pain and function during a subsequent pain-induction task. CLBP patients (n=71) and their spouses (n=71) participated in a 10-minute discussion followed by the patient undergoing a 10-minute structured pain behavior task (SPBT)...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28796116/pain-and-itch-outcome-trajectories-differ-among-european-american-and-african-american-survivors-of-major-thermal-burn-injury
#4
Matthew C Mauck, Jennifer Smith, Jeffrey W Shupp, Mark A Weaver, Andrea Liu, Andrey V Bortsov, Bilal Lateef, Samuel W Jones, Felicia Williams, James Hwang, Rachel Karlnoski, David J Smith, Bruce A Cairns, Samuel A McLean
Over half of individuals experiencing major thermal burn injury (MThBI) receive an autologous skin graft (autograft), in which skin is removed from a healthy "donor" site and transplanted to the burn site. Persistent pain/itch at the graft site are major causes of suffering and disability in MThBI survivors. African Americans have a higher risk of MThBI, and in other clinical settings African Americans experience a greater burden of pain and itch relative to European Americans. However, to our knowledge, ethnic differences in skin graft site pain/itch outcomes after MThBI have not been assessed...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28796115/cerebral-white-matter-structure-is-disrupted-in-gulf-war-veterans-with-chronic-musculoskeletal-pain
#5
Stephanie M VanRiper, Andrew L Alexander, Kelli F Koltyn, Aaron J Stegner, Laura D Ellingson, Daniel J Destiche, Ryan J Dougherty, Jacob B Lindheimer, Dane B Cook
Chronic musculoskeletal pain (CMP) affects ∼25% of the 700,000 Veterans deployed during the Persian Gulf War (1990-91). The cause of their pain is unknown and there are no efficacious treatments. A small body of literature suggests that brain abnormalities exist in Gulf War Veterans (GVs), yet relationships between brain abnormalities and disease symptoms remain largely unexplored. Our purpose was to compare white matter (WM) integrity between GVCMP and matched, healthy Veteran controls (GVCO) and investigate relationships between cerebral WM integrity and symptoms...
August 8, 2017: Pain
https://www.readbyqxmd.com/read/28806323/interactive-process-of-facial-communication-of-pain
#6
Miriam Kunz, Stefan Lautenbacher
No abstract text is available yet for this article.
August 2, 2017: Pain
https://www.readbyqxmd.com/read/28777124/a-new-optogenetic-device-for-spinal-cord-control-of-pain
#7
Alexander Chamessian, Ru-Rong Ji
No abstract text is available yet for this article.
August 2, 2017: Pain
https://www.readbyqxmd.com/read/28767505/age-dependent-plasticity-in-endocannabinoid-modulation-of-pain-processing-through-postnatal-development
#8
Charlie H-T Kwok, Ian M Devonshire, Amer Imraish, Charles M Greenspon, Stevie Lockwood, Catherine Fielden, Andrew Cooper, Stephen Woodhams, Sarir Sarmad, Catherine A Ortori, David A Barrett, David Kendall, Andrew J Bennett, Victoria Chapman, Gareth J Hathway
Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which modify pain responses but the role they play in acute responses to pain and postnatal neurodevelopment is unknown. Here we have studied the changing role of the ECs in brainstem nuclei essential for the control of nociception from birth to adulthood in both rat and human...
August 1, 2017: Pain
https://www.readbyqxmd.com/read/28767513/shedding-light-on-the-contribution-of-different-c-fibre-nociceptors-to-nocifensive-behavior
#9
Stefan G Lechner
No abstract text is available yet for this article.
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767512/dissecting-the-role-of-the-crmp2-neurofibromin-complex-on-pain-behaviors
#10
Aubin Moutal, Yue Wang, Xiaofang Yang, Yingshi Ji, Shizhen Luo, Angie Dorame, Shreya S Bellampalli, Lindsey A Chew, Song Cai, Erik T Dustrude, James E Keener, Michael T Marty, Todd W Vanderah, Rajesh Khanna
Neurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations or homozygous deletion of the Nf1 gene, is characterized by tumorigenesis, cognitive dysfunction, seizures, migraine, and pain. Omic studies on human NF1 tissues identified an increase in expression of collapsin response mediator protein 2 (CRMP2), a cytosolic protein reported to regulate the trafficking and activity of presynaptic N-type voltage-gated calcium (Cav2.2) channels. Since neurofibromin, the protein product of the Nf1 gene, binds to and inhibits CRMP2, the neurofibromin-CRMP2 signaling cascade will likely affect Ca2+ channel activity and regulate nociceptive neurotransmission and in vivo responses to noxious stimulation...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767511/protein-kinase-a-regulates-inflammatory-pain-sensitization-by-modulating-hcn2-channel-activity-in-nociceptive-sensory-neurons
#11
Stefan Herrmann, Hamsa Rajab, Irina Christ, Christoph Schirdewahn, Daniel Höfler, Michael Jm Fischer, Ariane Bruno, Stefanie Fenske, Christian Gruner, Felix Kramer, Tassilo Wachsmann, Christian Wahl-Schott, Juliane Stieber, Martin Biel, Andreas Ludwig
Several studies implicated cAMP as an important second messenger for regulating nociceptor sensitization, but downstream targets of this signaling pathway which contribute to neuronal plasticity are not well understood. We used a Cre/loxP based strategy to disable the function of either HCN2 or PKA selectively in a subset of peripheral nociceptive neurons and analyzed the nociceptive responses in both transgenic lines. A near complete lack of sensitization was observed in both mutant strains when peripheral inflammation was induced by intradermal injection of 8br-cAMP...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767510/psychological-interventions-that-target-sleep-reduce-pain-catastrophizing-in-knee-osteoarthritis
#12
Sheera F Lerman, Patrick H Finan, Michael T Smith, Jennifer A Haythornthwaite
Pain catastrophizing is a significant risk factor for patients with knee osteoarthritis (KOA) and thus is a target for many psychological interventions for pain. This study examined if interventions targeting sleep found to be effective in improving sleep in KOA also reduce pain catastrophizing measured as a trait through the pain catastrophizing scale and measured as a daytime and nocturnal state through daily diaries. Secondary analyses were conducted on data collected as part of a randomized controlled trial assessing the effectiveness of cognitive behavioral therapy for insomnia in patients with KOA at 5 different time points: pretreatment, midtreatment and posttreatment and at 3- and 6-month follow-up...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767509/persistent-postoperative-pain-after-cardiac-surgery-a-systematic-review-with-meta-analysis-regarding-incidence-and-pain-intensity
#13
Luís Guimarães-Pereira, Pedro Reis, Fernando Abelha, Luís Filipe Azevedo, José Manuel Castro-Lopes
Persistent postoperative pain (PPP) has been described as a complication of cardiac surgery (CS). We aimed to study PPP after CS (PPPCS) by conducting a systematic review of the literature regarding its incidence, intensity, location, and the presence of neuropathic pain, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The review comprised 3 phases: a methodological assessment of 6 different databases identifying potential articles and screening for inclusion criteria by 2 independent reviewers; data extraction; and study quality assessment...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767508/the-role-of-spatial-frequency-information-in-the-decoding-of-facial-expressions-of-pain-a-novel-hybrid-task
#14
Shan Wang, Christopher Ecclestona, Edmund Keogha
Spatial frequency (SF) information contributes to the recognition of facial expressions, including pain. Low-SF encodes facial configuration and structure and often dominates over high-SF information, which encodes fine details in facial features. This low-SF preference has not been investigated within the context of pain. In this study we investigated whether perpetual preference differences exist for low- and high-SF pain information. A novel hybrid expression paradigm was used, in which two different expressions, one containing low-SF information and the other high-SF information, were combined in a facial hybrid...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767507/bleeding-out-the-qalys-evaluating-the-burden-of-primary-dysmenorrhea-by-time-trade-off-and-willingness-to-pay-methods
#15
Fanni Rencz, Márta Péntek, Peep Fm Stalmeier, Valentin Brodszky, Gábor Ruzsa, Edina Gradvohl, Petra Baji, László Gulácsi
Primary dysmenorrhea (PD), or painful menstruation in the absence of identified uterine pathology, affects five to nine in every 10 reproductive-aged women. Despite its high prevalence, just a few studies with very small patient numbers have focused on health-related quality of life (HRQoL) impairment in PD. We aimed to assess HRQoL values for a severe and a mild hypothetical PD health state by 10-year time trade-off (TTO) and willingness-to-pay (WTP) methods. In 2015, a nationwide convenience sample of women, aged between 18 and 40 years, was recruited using an Internet-based cross-sectional survey in Hungary...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767506/defining-chronic-pain-in-epidemiological-studies-a-systematic-review-and-meta-analysis
#16
Ólöf Anna Steingrímsdóttir, Tormod Landmark, Gary J Macfarlane, Christopher Sivert Nielsen
The objective was to document the operational definitions applied in epidemiological studies of chronic pain and to examine whether pain definitions and other methodological factors are systematically related to prevalence estimates. Medline, EMBASE and PSYCHINFO were searched for original research reports with study samples of at least 1,000 individuals, excluding studies of less than five out of 15 selected body regions and studies solely concerned with specific pain conditions. Meta-analyses and meta-regressions were applied with random effects models; covariates were geography, sampling year, survey method, sampling frame, participation rate, percentage women of all participants, pain duration, and pain location...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28777772/oxytocin-pain-relief-in-skin
#17
Valery Grinevich, Alexandre Charlet
No abstract text is available yet for this article.
July 29, 2017: Pain
https://www.readbyqxmd.com/read/28731982/peripheral-oxytocin-receptors-inhibit-the-nociceptive-input-signal-to-spinal-dorsal-horn-wide-dynamic-range-neurons
#18
Abimael González-Hernández, Alfredo Manzano-García, Guadalupe Martínez-Lorenzana, Irma A Tello-García, Martha Carranza, Carlos Arámburo, Miguel Condés-Lara
Oxytocin (OT) has emerged as a mediator of endogenous analgesia in behavioral and electrophysiological experiments. In fact, OT receptors (OTRs) in the spinal dorsal horn participate in a selective inhibition of the neuronal activity mediated by Aδ and C fibers but not Aβ fibers. This study shows that OTRs are expressed in the terminal nerve endings and are able to inhibit nociceptive neuronal firing. Indeed, local peripheral OT blocked the first sensorial activity of Aδ and C fibers recorded in the spinal cord neurons...
July 19, 2017: Pain
https://www.readbyqxmd.com/read/28809765/cyclin-dependent-kinase-5-modulates-the-p2x2a-receptor-channel-gating-through-phosphorylation-of-c-terminal-threonine-372
#19
Claudio Coddou, Rodrigo Sandoval, Patricio Castro, Pablo Lazcano, Maria José Hevia, Milos Rokic, Bradford Hall, Anita Terse, Christian Gonzalez-Billault, Ashok B Kulkarni, Stanko S Stojilkovic, Elias Utreras
The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size variant P2X2aR (TPKH), which is absent in the splice variant P2X2bR. We therefore investigated the effects of Cdk5 and its neuronal activator, p35, on P2X2aR function. We found an interaction between P2X2aR and Cdk5/p35 by co-immunofluorescence and co-immunoprecipitation in HEK293 cells...
July 17, 2017: Pain
https://www.readbyqxmd.com/read/28708766/is-the-rationale-more-important-than-deception-a-randomized-controlled-trial-of-openlabel-placebo-analgesia
#20
Cosima Locher, Antje Frey Nascimento, Irving Kirsch, Joe Kossowsky, Andrea Meyer, Jens Gaab
Research on open-label placebos questions whether deception is a necessary characteristic of placebo effects. Yet, comparisons between open-label and deceptive placebos are lacking. We therefore assessed effects of open-label and deceptive placebos in comparison to no treatment with a standardized experimental heat pain paradigm in a RCT in healthy participants. Participants (N = 160) were randomly assigned to no treatment (NT), open-label placebo without rationale (OPR-), open-label placebo with rationale (OPR+) and deceptive placebo (DP)...
July 12, 2017: Pain
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