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Pain

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https://www.readbyqxmd.com/read/28221284/pain-interference-and-physical-function-demonstrate-poor-longitudinal-association-in-people-living-with-pain-a-promis-investigation
#1
Nicholas V Karayannis, John A Sturgeon, Ming Chih-Kao, Corinne Cooley, Sean C Mackey
A primary goal in managing pain is to reduce pain and increase physical function (PF). This goal is also tied to continuing payment for treatment services in many practice guidelines. Pain interference (PI) is often used as a proxy for measurement and reporting of PF in these guidelines. A common assumption is that reductions in PI will translate into improvement in PF over time. This assumption needs to be tested in a clinical environment. Consequently, we used the patient reported outcomes measurement information system (PROMIS) to describe the topology of the longitudinal relationship between PI in relation to PF...
February 16, 2017: Pain
https://www.readbyqxmd.com/read/28221285/genome-wide-methylation-analysis-of-a-large-population-sample-shows-neurological-pathways-involvement-in-chronic-widespread-musculoskeletal-pain-cwp
#2
Gregory Livshits, Ida Malkin, Maxim B Freidin, Yudong Xia, Fei Gao, Jun Wang, Timothy D Spector, Alex MacGregor, Jordana T Bell, Frances Mk Williams
Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component, which remains to be explained. Epigenetic factors may contribute to and account for some of the heritability estimate. We analysed epigenome-wide methylation using MeDIPseq in whole blood DNA from 1708 monozygotic (MZ) and dizygotic (DZ) Caucasian twins having CWP prevalence of 19.9%. Longitudinally stable methylation bins (lsBINs), were established by testing repeated measurements conducted ≥3 years apart, n=292. DNA methylation variation at lsBINs was tested for association with CWP in a discovery set of 50 MZ twin pairs discordant for CWP, and in an independent dataset (n=1608 twins), and the results from the two samples were combined using Fisher's method...
February 15, 2017: Pain
https://www.readbyqxmd.com/read/28221286/sickle-cell-disease-a-natural-model-of-acute-and-chronic-pain
#3
Amanda M Brandow, Katherine J Zappia, Cheryl L Stucky
No abstract text is available yet for this article.
February 13, 2017: Pain
https://www.readbyqxmd.com/read/28195856/pharmacoepidemiologic-analyses-of-opioid-use-among-oef-oif-ond-veterans
#4
Teresa J Hudson, Jacob T Painter, Brad Martin, Mark A Austen, James S Williams, John Fortney, Mark D Sullivan, Mark E Edlund
There is a great deal of concern about opioid use in Veterans, particularly those that served in Afghanistan (OEF) and Iraq (OIF and OND). The current study provides a detailed pharmacoepidemiologic analysis of opioid use among OEF/OIF/OND Veterans from FY09 to FY12. Data from three data repositories from the Veterans Health Administration (VHA) were used to describe demographic, clinical, and medication characteristics associated with opioid use among OEF/OIF/OND Veterans and among those with TBI. Logistic regression models were used to identify risks associated with chronic opioid use in FY12...
February 11, 2017: Pain
https://www.readbyqxmd.com/read/28195855/embodied-pain-negotiating-the-boundaries-of-possible-action
#5
Abby Tabor, Edmund Keogh, Christopher Eccleston
No abstract text is available yet for this article.
February 11, 2017: Pain
https://www.readbyqxmd.com/read/28195854/lateral-inhibition-during-nociceptive-processing
#6
Alexandre S Quevedo, Carsten Dahl Mørch, Ole K Andersen, Robert C Coghill
Spatial summation of pain is the increase of perceived intensity that occurs as the stimulated area increases. Spatial summation of pain is sub-additive in that increasing the stimulus area produces a disproportionately small increase in the perceived intensity of pain. A possible explanation for sub-additive summation may be that convergent excitatory information is modulated by lateral inhibition. To test the hypothesis that lateral inhibition may limit spatial summation of pain, we delivered different patterns of noxious thermal stimuli to the abdomens of 15 subjects using a computer-controlled CO2-laser...
February 11, 2017: Pain
https://www.readbyqxmd.com/read/28195858/psychophysical-and-psychological-predictors-of-acute-pain-after-breast-surgery-differ-in-patients-with-and-without-pre-existing-chronic-pain
#7
Ruth Ruscheweyh, Anika Viehoff, Joke Tio, Esther M Pogatzki-Zahn
The prediction of acute postoperative pain would be of great clinical advantage but results of studies investigating possible predictors are inconsistent. Here, we studied the role of a wide variety of previously suggested predictors in 74 patients undergoing breast surgery. Preoperatively, patients filled out the Pain Sensitivity Questionnaire (PSQ) and a set of psychological questionnaires (the Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and Pain Catastrophizing Scale (PCS)) and participated in an experimental pain testing session, including assessment of conditioned pain modulation (CPM), temporal summation, and responses to heat, pinprick and pressure pain...
February 9, 2017: Pain
https://www.readbyqxmd.com/read/28195857/pain-and-cancer-survival-a-cognitive-affective-model-of-symptom-appraisal-and-the-uncertain-threat-of-disease-recurrence
#8
L C Heathcote, C Eccleston
No abstract text is available yet for this article.
February 9, 2017: Pain
https://www.readbyqxmd.com/read/28178074/a-common-pro-nociceptive-pain-modulation-profile-typifying-subgroups-of-chronic-pelvic-pain-syndromes-is-interrelated-with-enhanced-clinical-pain
#9
Grinberg Keren, Granot Michal, Lowenstein Lior, Abramov Liora, Weissman-Fogel Irit
Provoked vestibulodynia (PVD) and painful bladder syndrome (PBS), subgroups of chronic pelvic pain syndromes (CPPS), are considered to share common bio-physiological peripheral mechanisms. In addition, indications of a pro-nociceptive pain profile co-existing with psychological vulnerability suggests common dysfunctional pain processing and pain modulation in these two subgroups of CPPS. We therefore aimed at comparing the pain profile and psychological traits of PVD and PBS patients to see whether the pain profile contributes to inter-subject variability of clinical pain symptoms...
February 7, 2017: Pain
https://www.readbyqxmd.com/read/28178073/return-to-work-helps-maintain-treatment-gains-in-the-rehabilitation-of-whiplash-injury
#10
Michael Sullivan, Heather Adams, Pascal Thibault, Emily Moore, Junie S Carrière, Christian Lariviere
The present study examined the relation between return-to-work and the maintenance of treatment gains made over the course of a rehabilitation intervention. The study sample consisted of 110 individuals who had sustained whiplash injuries in rear collision motor vehicle accidents and were work-disabled at the time of enrolment in the study. Participants completed pre- and post-treatment measures of pain severity, disability, cervical range of motion, depression, post-traumatic stress symptoms and catastrophizing...
February 7, 2017: Pain
https://www.readbyqxmd.com/read/28178072/side-effects-can-enhance-treatment-response-through-expectancy-effects-an-experimental-analgesic-randomized-controlled-trial
#11
Chantal Berna, Irving Kirsch, Sean R Zion, Yvonne C Lee, Karin B Jensen, Pamela Sadler, Ted J Kaptchuk, Robert R Edwards
In randomized controlled trials (RCTs), medication side effects may lead to beliefs that one is receiving the active intervention and enhance active treatment responses, thereby majoring drug-placebo differences. We tested these hypotheses with an experimental double-blind RCT of a nonsteroidal anti-inflammatory medication (NSAID) with and without the addition of atropine to induce side effects. One hundred healthy volunteers were told they would be randomized to either combined analgesics that might produce dry mouth or inert placebos...
February 4, 2017: Pain
https://www.readbyqxmd.com/read/28178071/recommendations-for-a-first-core-outcome-measurement-set-for-complex-regional-pain-syndrome-clinical-studies-compact
#12
Grieve Sharon, Perez Roberto Sgm, Birklein Frank, Brunner Florian, Bruehl Stephen, Harden R Norman, Packham Tara, Gobeil Francois, Haigh Richard, Holly Janet, Terkelsen Astrid, Davies Lindsay, Lewis Jennifer, Thomassen Ilona, Connett Robyn, Worth Tina, Vatine Jean-Jacques, McCabe Candida S
Complex Regional Pain Syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS.In 2013, an international consortium of patients, clinicians, researchers and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populationsThe development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process...
February 4, 2017: Pain
https://www.readbyqxmd.com/read/28157737/spinal-cord-interneurons-expressing-the-gastrin-releasing-peptide-receptor-convey-itch-through-vglut2-mediated-signaling
#13
Bejan Aresh, Fabio B Freitag, Sharn Perry, Edda Blümel, Joey Lau, Marina C M Franck, Malin C Lagerström
Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In the spinal cord, neurons expressing the gastrin releasing peptide receptor (GRPR) have been identified as specific mediators of itch. However, our understanding of the GRPR-population in the spinal cord, and thus how these neurons exercise their functions, is limited. For this purpose, we constructed a Cre line designed to target the GRPR population of neurons (Grpr-Cre). Our analysis revealed that Grpr-Cre cells in the spinal cord are predominantly excitatory interneurons that are found in the dorsal lamina, especially in lamina II-IV...
February 1, 2017: Pain
https://www.readbyqxmd.com/read/28151836/mechanism-based-cancer-pain-therapy
#14
Michael I Bennett
No abstract text is available yet for this article.
January 31, 2017: Pain
https://www.readbyqxmd.com/read/28151834/joint-pain-more-to-it-than-just-structural-damage
#15
Lars Arendt-Nielsen
No abstract text is available yet for this article.
January 31, 2017: Pain
https://www.readbyqxmd.com/read/28151833/lysophosphatidic-acid-signaling-is-the-definitive-mechanism-underlying-neuropathic-pain
#16
Hiroshi Ueda
No abstract text is available yet for this article.
January 31, 2017: Pain
https://www.readbyqxmd.com/read/28141634/neuroimaging-mechanisms-in-pain-from-discovery-to-translation
#17
Irene Tracey
For over twenty years neuroimaging has made a substantial impact on our understanding of human pain experiences within the experimental, acute and chronic setting. Functional activity that relates to the perceptual experience or its modulation, alongside structural, neurochemical and receptor changes, have given us remarkable insight to the extraordinary events that underpin human pain and its transition to or vulnerability towards chronic pain. These insights at a systems neuroscience level have largely focussed on the human brain and to a lesser extent the spinal cord; however, more recently preclinical neuroimaging using similar metrics is gathering pace...
January 30, 2017: Pain
https://www.readbyqxmd.com/read/28134655/a-central-role-for-r7bp-in-the-regulation-of-itch-sensation
#18
Mritunjay Pandey, Jian-Hua Zhang, Santosh K Mishra, Poorni R Adikaram, Benjamin Harris, John F Kahler, Anna Loshakov, Roxanne Sholevar, Allison Genis, Claire Kittock, Juraj Kabat, Sundar Ganesan, Richard R Neubig, Mark A Hoon, William F Simonds
Itch is a protective sensation producing a desire to scratch. Pathologic itch can be a chronic symptom of illnesses such as uremia, cholestatic liver disease, neuropathies and dermatitis, however current therapeutic options are limited. Many types of cell surface receptors, including those present on cells in the skin, on sensory neurons and on neurons in the spinal cord, have been implicated in itch signaling. The role of G protein signaling in the regulation of pruriception is poorly understood. We identify here two G protein signaling components whose mutation impairs itch sensation...
January 27, 2017: Pain
https://www.readbyqxmd.com/read/28134654/does-expecting-more-pain-make-it-more-intense-factors-associated-with-the-first-week-pain-trajectories-after-breast-cancer-surgery
#19
Reetta M Sipilä, Lassi Haasio, Tuomo J Meretoja, Samuli Ripatti, Ann-Mari Estlander, Eija A Kalso
The aim of this study was to identify clinical risk factors for unfavorable pain trajectories after breast cancer surgery in order to better understand the association between pain expectation, psychological distress, and acute postoperative pain. This prospective study included 563 women treated for breast cancer. Psychological data included questionnaires for depressive symptoms and anxiety. Experimental pain tests for heat and cold were performed before surgery. The amount of oxycodone needed for satisfactory pain relief after surgery was recorded...
January 27, 2017: Pain
https://www.readbyqxmd.com/read/28134653/transition-from-acute-to-chronic-pain-after-surgery
#20
Patricia Lavandʼhomme
No abstract text is available yet for this article.
January 25, 2017: Pain
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