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Shad B Smith, Marc Parisien, Eric Bair, Inna Belfer, Anne-Julie Chabot-Doré, Pavel Gris, Samar Khoury, Shannon Tansley, Yelizaveta Torosyan, Dmitri V Zaykin, Olaf Bernhardt, Priscila de Oliveira Serrano, Richard H Gracely, Deepti Jain, Marjo-Riitta Järvelin, Linda M Kaste, Kathleen F Kerr, Thomas Kocher, Raija Lähdesmäki, Nadia Laniado, Cathy C Laurie, Cecelia A Laurie, Minna Männikkö, Carolina B Meloto, Andrea G Nackley, Sarah C Nelson, Paula Pesonen, Margarete C Ribeiro-Dasilva, Celia M Rizzatti-Barbosa, Anne E Sanders, Christian Schwahn, Kirsi Sipilä, Tamar Sofer, Alexander Teumer, Jeffrey S Mogil, Roger B Fillingim, Joel D Greenspan, Richard Ohrbach, Gary D Slade, William Maixner, Luda Diatchenko
Painful temporomandibular disorders (TMD) is the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. While many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a GWAS assuming an additive genetic model of TMD in a discovery cohort of 999 cases and 2031 TMD-free controls from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study...
November 13, 2018: Pain
Gabrielle Green, Caroline Hartley, Amy Hoskin, Eugene Duff, Adam Shriver, Dominic Wilkinson, Eleri Adams, Richard Rogers, Fiona Moultrie, Rebeccah Slater
Changes in facial expression are an essential form of social communication, and in non-verbal infants are often used to alert care providers to pain-related distress. However, studies of early human brain development suggest that premature infants aged less than 34 weeks' gestation do not display discriminative brain activity patterns to equally salient noxious and innocuous events. Here we examine the development of facial expression in 105 infants, aged between 28 and 42 weeks' gestation. We show that the presence of facial expression change following noxious and innocuous stimulation is age-dependent and that discriminative facial expressions emerge from approximately 33 weeks' gestation...
November 12, 2018: Pain
Mls Sleijser-Koehorst, Bijker L, Cuijpers P, Ggm Scholten-Peeters, Coppieters Mw
The way people with musculoskeletal disorders deal with pain influences their prognosis. Psychosocial factors that influence outcomes include fear of movement, coping, self-efficacy and catastrophizing. A three-round modified Delphi study was conducted with the aim to reach consensus on the most appropriate questionnaires to assess these four psychosocial factors in patients at risk of developing persistent musculoskeletal pain. The panel consisted of 36 experts, with track records in medicine, psychology and allied health...
November 12, 2018: Pain
Jonas Petersen, Evanthia Mergia, Lea Kennel, Oliver Drees, Rebecca Dorothee Steubing, Catherine Isabell Real, Wiebke Kallenborn-Gerhardt, Ruirui Lu, Andreas Friebe, Doris Koesling, Achim Schmidtko
A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by two isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1 (NO-GC1) and 2 (NO-GC2). However, the specific functions of the two isoforms in pain processing remain elusive. Here we investigated the distribution of NO-GC1 and NO-GC2 in the spinal cord and dorsal root ganglia, and we characterized the behavior of mice lacking either isoform in animal models of pain...
November 12, 2018: Pain
Camilla Kristine Appel, Nicole Newell Scheff, Chi Tonglien Viet, Brian Lee Schmidt, Anne-Marie Heegaard
Bone cancer metastasis is extremely painful and decreases the quality of life of the affected patients. Available pharmacological treatments are not able to sufficiently ameliorate the pain and as cancer patients are living longer new treatments for pain management are needed. Decitabine (5-aza-2'-deoxycytidine), a DNA methyltransferases inhibitor, has analgesic properties in pre-clinical models of post-surgical and soft tissue oral cancer pain by inducing an up-regulation of endogenous opioids. In this study, we report that daily treatment with decitabine (2µg/g, i...
November 12, 2018: Pain
Brian Callaghan, Evan Reynolds, Mousumi Banerjee, Kevin Kerber, Lesli Skolarus, James Burke
We aimed to investigate the pattern and utilization of neuropathic pain medications in peripheral neuropathy patients. Using a privately-insured, healthcare claims database from 2001-2014, we identified a retrospective cohort of incident peripheral neuropathy patients (validated ICD-9 definition) after excluding other chronic pain conditions. Outcome measures included opioid prescriptions, chronic opioid therapy (greater than or equal to 90 days of continuous supply), guideline-recommended medications for painful peripheral neuropathy (serotonin reuptake inhibitors, tricyclic antidepressants, and gabapentinoids), and pain specialists (neurologists, physiatrists, and anesthesiologists)...
November 5, 2018: Pain
Laura Mustonen, Tommi Aho, Hanna Harno, Reetta Sipilä, Tuomo Meretoja, Eija Kalso
Nerve injury during breast cancer surgery can cause neuropathic pain (NP). It is not known why some, but not all, patients develop chronic postsurgical neuropathic pain (CPSNP) after the same nerve injury. In this study, we examined 251 breast cancer survivors with surgeon-verified intercostobrachial nerve resection to identify factors that associate with CPSNP. The patients were recruited from a previous study of 1000 women treated for breast cancer in 2006 to 2010. This enabled us to analyze preoperative factors that associate with future CPSNP...
October 30, 2018: Pain
Carolyn A Bernstein, Rony-Reuven Nir, Rodrigo Noseda, Anne B Fulton, Shaelah Huntington, Alice J Lee, Suzanne M Bertisch, Alexandra Hovaguimian, Catherine Buettner, David Borsook, Rami Burstein
Migraine-type photophobia, most commonly described as exacerbation of headache by light, affects nearly 90% of the patients. It is the most bothersome symptoms accompanying an attack. Using subjective psychophysical assessments, we showed that migraine patients are more sensitive to all colors of light during ictal than during interictal phase and that control subjects do not experience pain when exposed to different colors of light. Based on these findings, we suggested that color preference is unique to migraineurs (as it was not found in control subjects) rather than migraine phase (as it was found in both phases)...
October 29, 2018: Pain
Sarah Burkill, Scott Montgomery, Ingrid Kockum, Fredrik Piehl, Pernilla Strid, Jan Hillert, Lars Alfredsson, Tomas Olsson, Shahram Bahmanyar
Multiple sclerosis (MS) patients are at greater risk of pain than people without the disease, however the occurrence and characteristics of pain among these patients are incompletely described. We aimed to assess characteristics of pain amongst MS patients using MS patients who were recruited to participate in three studies in Sweden (n=3,877), and were matched with individuals without MS (n=4,548) by sex, year of birth, and region of residence. The Prescribed Drugs Register identified prescribed pain medication, overall and restricted to those given four or more prescriptions in one year to assess chronic pain...
October 29, 2018: Pain
Tao Chen, Junya Mu, Qianwen Xue, Ling Yang, Wanghuan Dun, Ming Zhang, Jixin Liu
To develop a machine learning model to investigate the discriminative power of whole-brain gray matter (GM) images derived from primary dysmenorrhea (PDM) women and healthy controls (HC) during the pain-free phase, and further evaluate the predictive ability of contributing features in predicting the variance in menstrual pain intensity. Sixty PDM patients and 54 matched female HC were recruited from the local university. All participants underwent the head and pelvic MRI scans to calculate GM volume and myometrium apparent diffusion coefficient (ADC) during their periovulatory phase...
October 29, 2018: Pain
Marcus Beasley, Maxim B Freidin, Neil Basu, Frances M K Williams, Gary J Macfarlane
Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used however are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems by using the Mendelian randomisation design to determine the effect of alcohol consumption on the likelihood of reporting CWP. The UK Biobank recruited 500,000 participants aged between 40 and 69 years. Data collected included questions on chronic pain and alcohol consumption, and biological samples providing genotypic information...
October 26, 2018: Pain
Kristian Kjær Petersen, Anne Estrup Olesen, Ole Simonsen, Lars Arendt-Nielsen
Joint inflammation is present in a subpopulation of knee osteoarthritic (KOA) patients. Pro-inflammatory cytokines are known to sensitize the peripheral and central pain pathways. This can be mechanistically assessed by pressure pain thresholds and temporal summation of pain (TSP). Non-steroidal anti-inflammatory drugs (NSAIDs) combined with paracetamol are recommended as OA treatment. The current study hypothesized that evidence of central sensitization would predict poor responses to peripherally directed therapies in KOA and therefore aimed to investigate the value of mechanistic pain profiling for predicting pain outcome of treatment with NSAIDs plus paracetamol...
October 26, 2018: Pain
Andrey V Bortsov, Marshall Devor, Mari A Kaunisto, Eija Kalso, Adam Brufsky, Henrik Kehlet, Eske Aasvang, Reinhard Bittner, Luda Diatchenko, Inna Belfer
Chronic postmastectomy pain (PMP) imposes a major burden on the quality of life of the ever-increasing number of long-term survivors of breast cancer. An earlier report by Nissenbaum et al. (2010) claimed that particular polymorphisms in the gene CACNG2 are associated with the risk of developing chronic PMP after breast surgery. This information is important as in principle it can inform the surgical, radiological and chemotherapeutic decision-making process in ways that could mitigate the increased risk of chronic pain...
October 26, 2018: Pain
Albert Lukas, Ulrich Hagg-Grün, Benjamin Mayer, Thomas Fischer, Matthias Schuler
Pain in combination with dementia is a common condition that makes pain recognition significantly more difficult. This results in undertreatment of pain in those suffering from dementia. The PAINAD (Pain Assessment in Advanced Dementia) pain assessment scale currently represents one of the best approaches to pain detection in dementia. In a pilot study, strong inter-rater and re-test reliability of the German version (PAINAD-G) was proven. However, the available data concerning the validity of this instrument were insufficient...
October 26, 2018: Pain
Marta Vila-Pueyo, Lauren C Strother, Malak Kefel, Peter J Goadsby, Philip R Holland
Migraine is a common disabling neurological condition that is associated with several premonitory symptoms that can occur days before the headache onset. The most commonly reported premonitory symptom is marked fatigue that has been shown to be highly predictive of an ensuing migraine attack.The locus coeruleus (LC) is a key nucleus involved in arousal that has also been shown to impact pain processing. It provides one of the major sources of noradrenaline to the dorsal horn of the spinal cord and neocortex...
October 26, 2018: Pain
Duane B Corbett, Corey B Simon, Todd M Manini, Steven Z George, Joseph L Riley, Roger B Fillingim
No abstract text is available yet for this article.
October 26, 2018: Pain
Gregory Livshits, Ida Malkin, Ruth C E Bowyer, Serena Verdi, Jordana T Bell, Cristina Menni, Frances M K Williams, Claire J Steves
Chronic widespread musculoskeletal pain (CWP) and frailty are prevalent conditions in older people. We have shown previously that interindividual variation in frailty and CWP is genetically determined. We also reported an association of frailty and CWP caused by shared genetic and common environmental factors. The aim of this study was to use omic approaches to identify molecular genetic factors underlying the heritability of frailty and its genetic correlation with CWP. Frailty was quantified through the Rockwood Frailty Index (FI) as a proportion of deficits from 33 binary health deficit questions in 3626 female twins...
October 25, 2018: Pain
Amanda M Brandow, Karla Hansen, Melodee Nugent, Amy Pan, Julie A Panepinto, Cheryl L Stucky
Sickle cell disease (SCD) pain associates with cold temperature and touch. Patients and murine models with SCD have baseline thermal and mechanical pain. In SCD mice, the baseline hypersensitivity is exacerbated by experimental vaso-occlusive crises. We hypothesized that patients with SCD will similarly experience increased hypersensitivity to thermal and mechanical stimuli during acute painful events compared with baseline health. We conducted a prospective study of 24 patients with SCD aged 7 to 19 years...
October 18, 2018: Pain
Jingjing Yuan, Jing Wen, Shaogen Wu, Yuanyuan Mao, Kai Mo, Zhisong Li, Songxue Su, Hanwen Gu, Yanqiu Ai, Alex Bekker, Wei Zhang, Yuan-Xiang Tao
Neuropathic pain genesis is related to gene alterations in the dorsal root ganglion (DRG) after peripheral nerve injury. Transcription factors control gene expression. In this study, we investigated whether octamer transcription factor 1 (OCT1), a transcription factor, contributed to neuropathic pain caused by chronic constriction injury (CCI) of the sciatic nerve. Chronic constriction injury produced a time-dependent increase in the level of OCT1 protein in the ipsilateral L4/5 DRG, but not in the spinal cord...
October 18, 2018: Pain
Kathryn A Birnie, Amos S Hundert, Chitra Lalloo, Cynthia Nguyen, Jennifer N Stinson
In 2006, PAIN published a systematic review of the measurement properties of self-report pain intensity measures in children and adolescents (Stinson JN, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. PAIN 2006;125:143-57). Key developments in pediatric pain necessitate an update of this work, most notably growing use of the 11-point numeric rating scale (NRS-11)...
October 18, 2018: Pain
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