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Max A Odem, Alexis G Bavencoffe, Ryan M Cassidy, Elia R Lopez, Jinbin Tian, Carmen W Dessauer, Edgar T Walters
Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent models of pain-related OA have concentrated on allodynia rather than ongoing pain, and on OA generated in non-nociceptive Aβ-fibers rather than C-fiber nociceptors. Little is known about how ongoing pain or nociceptor OA is generated. To define neurophysiological alterations underlying nociceptor OA, we have utilized isolated dorsal root ganglion neurons that continue to generate OA after removal from animals displaying ongoing pain...
July 12, 2018: Pain
Fadel Zeidan, Tim Salomons, Suzan R Farris, Nichole M Emerson, Adrienne Adler- Neal, Youngkyoo Jung, Robert C Coghill
Inter-individual differences in pain sensitivity vary as a function of interactions between sensory, cognitive-affective and dispositional factors. Trait mindfulness, characterized as the innate capacity to non-reactively sustain attention to the present moment, is a psychological construct that is associated with lower clinical pain outcomes. Yet, the neural mechanisms supporting dispositional mindfulness are unknown. In an exploratory data analysis obtained during a study comparing mindfulness to placebo-analgesia, we sought to determine if dispositional mindfulness is associated with lower pain sensitivity...
July 12, 2018: Pain
Megan M Miller, Samantha M Meints, Adam T Hirsh
Pediatric chronic pain is associated with numerous negative outcomes including increased physical disability, increased rates of depression and anxiety, and decreased quality of life. Pain catastrophizing- broadly conceptualized as including rumination, magnification, and helplessness cognitions surrounding one's pain - has been linked with poor functional outcomes in children with chronic pain. Pain catastrophizing in pediatric chronic pain is often considered a key factor on which to focus treatment efforts...
July 12, 2018: Pain
Amy J D Hampton, Thomas Hadjistavropoulos, Michelle M Gagon
We aimed to examine the effects of contextual factors (i.e., observers' training background and priming texts) on decoding facial pain expressions of younger and older adults. A total of 165 participants (82 nursing students and 83 non-health professionals) were randomly assigned to one of three priming conditions: (1) information about the possibility of secondary gain [misuse]; (2) information about the frequency and undertreatment of pain in the older adult [undertreament]; or (3) neutral information [control]...
July 12, 2018: Pain
Matthijs J L Perenboom, Amir H Zamanipoor Najafabadi, Ronald Zielman, Johannes A Carpay, Michel D Ferrari
Enhanced sensitivity to light (photophobia) and patterns is common in migraine, and can be regarded as visual allodynia. We aimed to develop and validate a questionnaire to easily quantify sensitivity to light and patterns in large populations, and to assess and compare visual allodynia across different migraine subtypes and states. We developed the Leiden Visual Sensitivity Scale (L-VISS), a 9-item scale (score range 0-36 points), based on literature and patient interviews, and examined its construct validity...
July 12, 2018: Pain
Nanna B Finnerup, Simon Haroutounian, Ralf Baron, Robert H Dworkin, Ian Gilron, Maija Haanpaa, Troels S Jensen, Peter R Kamerman, Ewan McNicol, Andrew Moore, Srinivasa N Raja, Niels T Andersen, Emily S Sena, Blair H Smith, Andrew Sc Rice, Nadine Attal
Multiple recent pharmacological clinical trials in neuropathic pain have failed to show beneficial effect of drugs with previously demonstrated efficacy, and estimates of drug efficacy seems to have decreased with accumulation of newer trials. However, this has not been systematically assessed. Here we analyze time-dependent changes in estimated treatment effect size in pharmacological trials together with factors that may contribute to decreases in estimated effect size. This study is a secondary analysis of data from a previous published NeuPSIG systematic review and meta-analysis, updated to include studies published up till March 2017...
July 12, 2018: Pain
Yanping Gu, Guangwen Li, Li-Yen Mae Huang
The Exchange proteins activated by cAMP (Epacs) have been shown to play important roles in producing inflammation-induced nociception. Transient receptor potential vanilloid type 1 (TRPV1) is a major receptor processing thermal and chemo-sensitive nociceptive information. The role of Epacs in modulating the activity of TRPV1 has yet to be determined. Studying the effect of complete Freund's adjuvant (CFA)-induced inflammation on capsaicin-activated TRPV1 nociceptive responses in dorsal root ganglia (DRGs), we found that CFA produced a large increase in capsaicin-induced responses...
July 12, 2018: Pain
M J Iadarola, M R Sapio, S J Raithel, A J Mannes, D C Brown
The translational potential of analgesic approaches emerging from basic research can be augmented by client-owned dog trials. We report on a peripheral interventional approach that uses intra-articular injection of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) to produce a selective long-term chemo-inactivation of nociceptive primary afferent nerve endings for pain control in naturally-occurring canine osteoarthritis. A single injection of 10µg of RTX, produced suppression of pain, improvement in gait, weight bearing, and improvement in the dog's activities of daily living lasting 4 months or longer...
July 10, 2018: Pain
Brandon J Rea, Anne-Sophie Wattiez, Jayme S Waite, William C Castonguay, Chantel M Schmidt, Aaron M Fairbanks, Bennett R Robertson, Cameron J Brown, Bianca N Mason, Maria-Cristina Moldovan-Loomis, Leon F Garcia-Martinez, Pieter Poolman, Johannes Ledolter, Randy H Kardon, Levi P Sowers, Andrew F Russo
Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of therapeutic antibodies that block the actions of the neuropeptide calcitonin gene-related peptide (CGRP) or its receptor to prevent migraine. CGRP is believed to contribute to trigeminal nerve hypersensitivity and photosensitivity in migraine, but a direct role in pain associated with migraine has not been established...
July 9, 2018: Pain
Hocine Slimani, Leon Plaghki, Paola Valenti, Mads U Werner, Henrik Kehlet, Ron Kupers
It remains unclear which nerve fibers are responsible for mediating hyperalgesia following skin injury. Here, we examined the role of A∂- and C-fibers in inflammatory hyperalgesia following a first-degree burn injury. A CO2-laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg, to stimulate selectively the relatively fast conducting thinly myelinated A∂ and the slowly conducting unmyelinated C-fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus...
July 9, 2018: Pain
James R Hunt, Megan Goff, Helen Jenkins, John Harris, Toby G Knowles, B Duncan X Lascelles, Masataka Enomoto, Mike Mendl, Becky Whay, Joanna C Murrell
In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS in preclinical and clinical studies. It was hypothesised that dogs suffering from OA would exhibit electrophysiological characteristics indicative of CS, associated with reduced diffuse noxious inhibitory controls (DNIC). 117 client owned dogs were recruited to the study...
July 9, 2018: Pain
Sophie Lykkegaard Ravn, Jan Hartvigsen, Maj Hansen, Michele Sterling, Tonny Elmose Andersen
Following traumatic exposure, individuals are at risk of developing symptoms of both pain and post-traumatic stress disorder (PTSD). Theory and research suggest a complex and potentially mutually maintaining relationship between these symptomatologies. However, findings are inconsistent and the applied methods are not always well suited for testing mutual maintenance. Cross-lagged designs can provide valuable insights into such temporal associations, but there is a need of a systematic review to assist clinicians and researchers in understanding the nature of the relationship...
July 2, 2018: Pain
Peter D Drummond, Natalie Morellini, Philip M Finch, Frank Birklein, Lone F Knudsen
The aim of this study was to determine whether upregulated cutaneous expression of α1-adrenoceptors (α1-AR) is a source of pain in patients with complex regional pain syndrome (CRPS). Immunohistochemistry was used to identify α1-AR on nerve fibres and other targets in the affected and contralateral skin of 90 patients, and in skin samples from 38 pain-free controls. The distribution of α1-AR was compared between patients and controls, and among subgroups of patients defined by CRPS duration, limb temperature asymmetry and diagnostic subtype (CRPS I versus CRPS II)...
July 2, 2018: Pain
Lisa A Majuta, Stefanie A T Mitchell, Michael A Kuskowski, Patrick W Mantyh
Anti-NGF therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effects of anti-NGF treatment on physical activity in normal young (3 months old) and aging (18-23 months old) mice and mice with bone fracture pain. Although aging mice were clearly less active and showed loss of bone mass compared to young mice, anti-NGF treatment had no effect on any measure of day/night activity in either the young or aging mice...
July 2, 2018: Pain
R L Bosma, J A Kim, J C Cheng, A Rogachov, K S Hemington, N R Osborne, J Oh, K D Davis
Pain is a prevalent and debilitating symptom of multiple sclerosis (MS), yet the mechanisms underlying this pain are unknown. Previous studies have found that the functional relationships between the salience network, specifically the right temporoparietal junction a salience node (SN), and other components of the dynamic pain connectome (default mode (DMN), ascending and descending pathways) are abnormal in many chronic pain conditions. Here we use resting state fMRI and measures of static and dynamic functional connectivity (sFC, dFC), and regional BOLD variability to test the hypothesis that MS patients have abnormal DMN-SN cross-network sFC, SN-ascending and SN-descending pathways dFC, and disrupted BOLD variability in the dynamic pain connectome that relate to pain inference and neuropathic pain...
July 2, 2018: Pain
Antonio Rodriguez-Gaztelumendi, Viola Spahn, Dominika Labuz, Halina Machelska, Christoph Stein
Recently, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a newly designed μ-opioid receptor (MOR) agonist with a low pKa, has been shown to produce injury-restricted analgesia in models of inflammatory and postoperative pain, without exhibiting typical opioid side effects. Here, we investigated MOR binding of NFEPP in brain and dorsal root ganglia (DRG), pH in injured tissues, and the analgesic efficacy of NFEPP compared to fentanyl in a chronic constriction injury (CCI) model of neuropathic pain, and in the acetic acid-induced abdominal writhing assay in rats...
July 2, 2018: Pain
R Andrew Moore, Sheena Derry, Philip J Wiffen, Samik Banerjee, Rajesh Karan, Ekkehard Glimm, Anna Wiksten, Dominic Aldington, Christopher Eccleston
Network meta-analysis (NMA) uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. NMA uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of acute postoperative pain trials and other systematic reviews to provide data to test this hypothesis. Some 261 trials published between 1966-2016 included 39,753 patients examining 52 active drug and dose combinations (27,726 given active drug, 12,027 placebo), in any type of surgery (72% dental)...
June 29, 2018: Pain
Stephanie Mouchbahani-Constance, L Stephen Lesperance, Hugues Petitjean, Albena Davidova, Amanda Macpherson, Steven A Prescott, Reza Sharif-Naeini
The lionfish (Pterois volitans) is a venomous invasive species found in the Caribbean and Northwestern Atlantic. It poses a growing health problem due to the increase in frequency of painful stings, for which no treatment or antidote exists, and the long-term disability caused by the pain. Understanding the venom's algogenic properties can help identifying better treatment for these envenomations. In this study, we provide the first characterization of the pain and inflammation caused by lionfish venom and examine the mechanisms through which it causes pain using a combination of in vivo and in vitro approaches including behavioral, physiological, calcium imaging and electrophysiological testing...
June 29, 2018: Pain
Kushang V Patel, Robert Allen, Laurie Burke, John T Farrar, Jennifer S Gewandter, Ian Gilron, Nathaniel P Katz, John D Markman, Scott F Marshall, Malca Resnick, Andrew S C Rice, Michael C Rowbotham, Shannon M Smith, Geertrui F Vanhove, Ajay D Wasan, Shuyu Zhang, Robert H Dworkin, Dennis C Turk
Integrating information on physical function and pain intensity into a composite measure may provide a useful method for assessing treatment efficacy in clinical trials of chronic pain. Accordingly, we evaluated composite outcomes in trials of duloxetine, gabapentin, and pregabalin. Data on 2,287 patients in 9 trials for painful diabetic peripheral neuropathy (DPN) and 1,513 patients in 6 trials for postherpetic neuralgia (PHN) were analyzed. All trials assessed pain intensity on a 0-10 numeric rating scale and physical function with the 10-item subscale of the Short Form-36, ranging 0-100 with higher scores indicating better function...
June 25, 2018: Pain
Xin Zhao, Chao Yu, Feng Ye, Yan-Gui Wang, Qi-Yong Mei, Qing Ma, Wu-Geng Cui, Wen-Hu Zhou
Chronic itch is clinically correlated with the development of mood disorders such as anxiety and depression. Nonetheless, whether this relevance exists in rodents is unknown, and evidence demonstrating chronic itch can affect mood is lacking. The aim of this study is to characterize the affective consequences of chronic itch, and explore potential mechanisms and interventional strategy. We subjected mice to chronic itch by repetitively cutaneous treatment with acetone and diethylether followed by water (AEW) that models "dry skin"...
June 22, 2018: Pain
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