journal
MENU ▼
Read by QxMD icon Read
search

Pain

journal
https://www.readbyqxmd.com/read/29351172/a-systematic-review-and-meta-analysis-of-genetic-risk-factors-for-neuropathic-pain
#1
Abirami Veluchamy, Harry L Hébert, Weihua Meng, Colin N A Palmer, Blair H Smith
Neuropathic pain (NP) is an increasingly common chronic pain state and a major health burden, affecting approximately 7-10% of the general population. Emerging evidence suggests that genetic factors could partially explain individual susceptibility to NP and the estimated heritability in twins is 37%. The aim of this study was to systematically review and summarize the studies in humans that have investigated the influence of genetic factors associated with NP. We conducted a comprehensive literature search and performed meta-analyses of all the potential genetic variants associated with NP...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29351171/spinal-pkc-erk-signal-pathway-mediates-hyperalgesia-priming
#2
Wei-Hsin Chen, Ya-Ting Chang, Yong-Cyuan Chen, Sin-Jhong Cheng, Chien-Chang Chen
Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Here we showed that spinal PKC/ERK signal pathway is required for neuronal plasticity change, hyperalgesic priming formation and the development of chronic hyperalgesia using acid-induced muscle pain (AIMP) model in mice...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29351170/risk-of-preterm-birth-following-late-pregnancy-exposure-to-nsaids-or-cox-2-inhibitors
#3
Anick Bérard, Odile Sheehy, Sylvie Girard, Jin-Ping Zhao, Sasha Bernatsky
Pregnant women may take non-steroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitors or biologic agents to relieve symptoms or manage disease flares in late pregnancy. We aimed to quantify the risk of prematurity associated with late pregnancy exposure to non-selective NSAIDs, selective COX-2 inhibitors and biologic agents. Using data from Quebec Pregnancy Cohort, we performed a population-based cohort study. We included all women who were covered by the Quebec Drug Plan and had a singleton livebirth between 1/1/1998 and 31/12/2009...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29351169/professionals-underestimate-patients-pain-a-comprehensive-review
#4
Tim Seers, Sheena Derry, Kate Seers, R Andrew Moore
Pain assessment by patient is the rule in clinical trials, but may not be in clinical practice. We examined studies comparing patient and professional assessment of pain in clinical practice using published studies (1990-2016; ≥20 patients), in English, comparing pain assessment within 24 hours by patient and healthcare professional. A difference of at least 10% of the maximum score was considered significant. We judged quality on sampling method, blinding, and study size.Eighty studies (20,496 patients) provided data from a range of settings and locations; most (51%) used unbiased sampling, and most (68%) were blind or probably blind...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29351168/co-regulation-of-er-stress-and-oxidative-stress-in-neuropathic-pain-and-disinhibition-of-the-spinal-nociceptive-circuitry
#5
Yanhu Ge, Yingfu Jiao, Peiying Li, Zhenghua Xiang, Zhi Li, Long Wang, Wenqian Li, Hao Gao, Jiayun Shao, Daxiang Wen, Weifeng Yu
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) lumen leads to ER stress, which is related to cellular reactive oxygen species (ROS) production. Neuropathic pain may result from spinal dorsal horn (SDH) ER stress. In this study, we examined the cause-effect relationship between ER stress and neuropathic pain using the spinal nerve ligation(SNL) rat model. We showed that ER stress was mutually promotive with oxidative stress during the process. We also tested the hypothesis that spinal sensitization arose from reduced activities of GABA-ergic interneurons and that spinal sensitization was mediated by SDH ER stress...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29351125/central-inhibition-of-granulocyte-macrophage-colony-stimulating-factor-is-analgesic-in-experimental-neuropathic-pain
#6
Louise S C Nicol, Peter Thornton, Jon P Hatcher, Colin P Glover, Carl I Webster, Matthew Burrell, Kessia Hammett, Clare A Jones, Matthew A Sleeman, Andrew Billinton, Iain Chessell
With less than 50% of patients responding to the current standard of care and poor efficacy and selectivity of current treatments, neuropathic pain continues to be an area of considerable unmet medical need. Biological therapeutics such as monoclonal antibodies (mAbs) provide better intrinsic selectivity; however, delivery to the central nervous system (CNS) remains a challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is well described in inflammation-induced pain, and early-phase clinical trials evaluating its antagonism have exemplified its importance as a peripheral pain target...
January 16, 2018: Pain
https://www.readbyqxmd.com/read/29319611/comparison-of-somatosensory-cortex-excitability-between-migraine-and-strict-criteria-tension-type-headache-a-magnetoencephalographic-study
#7
Wei-Ta Chen, Fu-Jung Hsiao, Yu-Chieh Ko, Hung-Yu Liu, Pei-Ning Wang, Jong-Ling Fuh, Yung-Yang Lin, Shuu-Jiun Wang
Tension-type headache (TTH) and migraine are both common types of headaches. Despite distinct symptoms, TTH and migraine are highly comorbid and exhibit many clinical similarities. This study enrolled consecutive patients with TTH and age- and sex-matched patients with migraine and healthy controls to investigate whether TTH and migraine are similar in brain excitability change assessed by magnetoencephalography. Patients with TTH were excluded if they reported any headache features or associated symptoms of migraine...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29319610/the-effectiveness-of-online-pain-resources-for-health-professionals-a-systematic-review-with-subset-meta-analysis-of-educational-intervention-studies
#8
Christina Liossi DPsych, Alessandro Failo PhD, Daniel E Schoth PhD, Glyn Williams Md, Richard Howard Md
Online educational interventions are increasingly developed for health professionals and students, although graduate and undergraduate medical curricular often contain limited information about how to assess and manage pain. This study reviews the literature on the effectiveness of pain-related online educational resources. Studies were identified via a search of Medline, PsychINFO, Web of Science, CINAHL, PubMed, Scopus, Cochrane Library, Google Scholar and OpenGrey databases. Search terms included three concept blocks: (i) type of intervention - online education, computer-based, e-learning, web-based, and internet-based; (ii) population - pediatrician, physician, nurse, psychologist, medical; (iii) outcome - pain*...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29319609/joint-nociceptor-nerve-activity-and-pain-in-an-animal-model-of-acute-gout-and-its-modulation-by-intra-articular-hyaluronan
#9
Aida Marcotti, Ana Miralles, Eduardo Dominguez, Eliseo Pascual, Ana Gomis, Carlos Belmonte, Elvira de la Peña
The mechanisms whereby monosodium urate (MSU) crystals deposition in gout activate nociceptors to induce joint pain are incompletely understood. We tried to reproduce the signs of painful gouty arthritis, injecting into the knee joint of rats suspensions containing amorphous or triclinic, needle MSU crystals. The magnitude of MSU-induced inflammation and pain behavior signs was correlated with the changes in firing frequency of spontaneous and movement-evoked nerve impulse activity recorded in single knee joint nociceptor saphenous nerve fibers...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29319608/novel-approach-to-characterising-individuals-with-low-back-related-leg-pain-cluster-identification-with-latent-class-analysis-and-12-month-follow-up
#10
Siobhán Stynes, Kika Konstantinou, Reuben Ogollah, Elaine M Hay, Kate M Dunn
Traditionally, low back-related leg pain (LBLP) is diagnosed clinically as referred leg pain or sciatica (nerve root involvement). However, within the spectrum of LBLP, we hypothesised that there may be other unrecognised patient subgroups. This study aimed to identify clusters of patients with LBLP using latent class analysis and describe their clinical course. The study population was 609 LBLP primary care consulters. Variables from clinical assessment were included in the latent class analysis. Characteristics of the statistically identified clusters were compared, and their clinical course more than 1 year was described...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29319607/longitudinal-resting-state-fmri-in-a-mouse-model-of-metastatic-bone-cancer-reveals-distinct-functional-reorganizations-along-a-developing-chronic-pain-state
#11
David Buehlmann, Joanes Grandjeanc, Jael Xandryd, Markus Rudin
Functional neuroimaging has emerged as attractive option for characterizing pain states complementing behavioral readouts or clinical assessment. In particular resting-state fMRI (rs-fMRI) enables monitoring of functional adaptations across the brain, e.g. in response to chronic nociceptive input. We have used rs-fMRI in a mouse model of chronic pain from breast cancer derived tibial bone metastases to identify pain-induced alterations in functional connectivity (FC). Combined assessment of behavioral readouts allowed defining a trajectory as model function for extracting pain-specific FC changes from the fMRI data reflective of a chronic pain state...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29319606/disruption-of-nnos-nos1ap-protein-protein-interactions-suppresses-neuropathic-pain-in-mice
#12
Wan-Hung Lee, Li-Li Li, Aarti Chawla, Andy Hudmon, Yvonne Y Lai, Michael J Courtney, Andrea G Hohmann
Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential due to their adverse side effects. Novel approaches targeting the NR2B-PSD95-nNOS complex to disrupt signaling pathways downstream of NMDARs show efficacy in preclinical pain models. Here, we evaluated the involvement of interactions between neuronal nitric oxide synthase (nNOS) and the nitric oxide synthase 1 adaptor protein (NOS1AP) in pronociceptive signaling and neuropathic pain...
January 9, 2018: Pain
https://www.readbyqxmd.com/read/29298215/are-group-size-and-composition-associated-with-treatment-outcomes-in-group-cognitive-behavioural-therapy-for-chronic-pain
#13
Dianne Wilson, M App Sc, Shylie Mackintosh, Michael K Nicholas, G Lorimer Moseley, Daniel Costa, Claire Ashton-James
This study explored whether group size and group member characteristics (age, gender, compensation status) were associated with patient outcomes (changes in pain and disability). Retrospective analyses of outcome data obtained from two independently run group Cognitive Behavioural Therapy (CBT) programs for chronic pain (Program A: N = 317 and Program B: N = 693) were conducted. Intracluster correlations (ICCs) were significant in both studies, indicating group-level effects on patient outcomes in both group CBT programs for chronic pain...
December 29, 2017: Pain
https://www.readbyqxmd.com/read/29300280/sensory-profiling-in-animal-models-of-neuropathic-pain-a-call-for-back-translation
#14
Andrew S C Rice, Nanna B Finnerup, Harriet I Kemp, Gillian L Currie, Ralf Baron
No abstract text is available yet for this article.
December 26, 2017: Pain
https://www.readbyqxmd.com/read/29300279/disease-modifying-actions-of-il-6-blockade-in-a-rat-model-of-bone-cancer-pain
#15
Bethany Remeniuk, Tamara King, Devki Suktankhar, Amy Nippert, Nancy Li, Fuying Li, Kejun Cheng, Kenner C Rice, Frank Porreca
Metastasis of cancer to the skeleton represents a debilitating turning point in the lives of patients. Skeletal metastasis leads to moderate to severe ongoing pain along with bone remodeling that can result in fracture, events that dramatically diminish quality of life. IL-6 levels are elevated in metastatic breast cancer patients and are associated with a lower survival rate. We therefore determined the consequences of inhibition of IL-6 signaling using a novel small molecule antagonist, TB-2-081, on bone integrity, tumor progression, and pain in a rodent model of breast cancer...
December 26, 2017: Pain
https://www.readbyqxmd.com/read/29300278/the-human-pain-genetics-database-hpgdb-a-resource-dedicated-to-human-pain-genetics-research
#16
Carolina B Meloto, Rodrigo Benavides, Ryan N Lichtenwalter, Xia Wen, Nicol Tugarinov, Katerina Zorina-Lichtenwalter, Anne-Julie Chabot-Doré, Marjo H Piltonen, Stefano Cattaneo, Vivek Verma, Richard Klares, Samar Khoury, Marc Parisien, Luda Diatchenko
The Human Pain Genetics Database (HPGDB) is a comprehensive variant-focused inventory of genetic contributors to human pain. After curation, the HPGDB currently includes 294 studies reporting associations between 434 distinct genetic variants and various pain phenotypes. Variants were then submitted to a comprehensive analysis. First, they were validated in an independent high-powered replication cohort by testing the association of each variant with ten different pain phenotypes (n=1,320 to 26,973). One-hundred-fifty-five variants replicated successfully (FDR 20%) in at least one pain phenotype, and the association P-values of the HPGDB variants were significantly lower compared to those of random controls...
December 18, 2017: Pain
https://www.readbyqxmd.com/read/29300277/developing-a-core-outcome-domain-set-to-assessing-effectiveness-of-interdisciplinary-multimodal-pain-therapy-the-vapain-consensus-statement-on-core-outcome-domains
#17
Ulrike Kaiser, Christian Kopkow, Stefanie Deckert, Katrin Neustadt, Lena Jacobi, Paul Cameron, Valerio De Angelis, Christian Apfelbacher, Bernhard Arnold, Judy Birch, Anna Bjarnegård, Sandra Christiansen, Amanda Williams C de C, Gudrun Gossrau, Andrea Heinks, Michael Hüppe, Henri Kiers, Ursula Kleinert, Paolo Martelletti, Lance McCracken, Nelleke de Meij, Bernd Nagel, Jo Nijs, Heike Norda, Jasvinder A Singh, Ellen Spengler, Caroline Terwee, Tugwell Peter, Johan W S Vlaeyen, Heike Wandrey, Edmund Neugebauer, Rainer Sabatowski, Jochen Schmitt
Interdisciplinary multimodal pain therapy (IMPT) is a biopsychosocial treatment approach for patients with chronic pain that comprises at least psychological and physiotherapeutic interventions. Core Outcome Sets (COSs) are currently developed in different medical fields to standardize and improve the selection of outcome-domains, and measurement instruments in clinical trials, to make trial results meaningful, to pool trial results, and to allow indirect comparison between interventions. The objective of this study was to develop a COS of patient-relevant outcome-domains for chronic pain in IMPT clinical trials...
December 18, 2017: Pain
https://www.readbyqxmd.com/read/29320375/psychological-flexibility-mediates-the-effect-of-an-online-based-acceptance-and-commitment-therapy-for-chronic-pain-an-investigation-of-change-processes
#18
Jiaxi Lin, Laura-Isabelle Klatt, Lance M McCracken, Harald Baumeister
One way to improve treatment effects of chronic pain is to identify and improve control over mechanisms of therapeutic change. One treatment approach that includes a specific proposed mechanism is acceptance and commitment therapy (ACT) with its focus on increasing psychological flexibility (PF). The aim of the present study was to examine the role of PF as a mechanism of change in ACT. This is based on mediation analyses of data from a previously reported randomized controlled trial, evaluating the effectiveness of an ACT-based online intervention for chronic pain (ACTonPain)...
December 15, 2017: Pain
https://www.readbyqxmd.com/read/29252911/pain-as-a-risk-factor-for-common-mental-disorders-results-from-the-netherlands-mental-health-survey-and-incidence-study-2-a-longitudinal-population-based-study
#19
Eric W de Heer, Margreet Ten Have, Harm W J van Marwijk, Jack Dekker, Ron de Graaf, Aartjan T F Beekman, Christina M van der Feltz-Cornelis
Pain might be an important risk factor for common mental disorders. Insight into the longitudinal association between pain and common mental disorders in the general adult population could help improve prevention and treatment strategies. Data were used from the first two waves of the Netherlands Mental Health Survey and Incidence Study-2, a psychiatric epidemiological cohort study among the Dutch general population aged 18-64 years at baseline (N=5,303). Persons without a mental disorder 12 months prior to baseline were selected as the at-risk group (n=4,974 for any mood disorder; n=4,979 for any anxiety disorder; n=5,073 for any substance use disorder)...
December 15, 2017: Pain
https://www.readbyqxmd.com/read/29252910/validation-of-the-pain-block-concrete-ordinal-scale-for-children-aged-4-7-years
#20
Jin Hee Jung, Jin Hee Lee, Do Kyun Kim, Jae Yun Jung, Ik Wan Chang, Hyuksool Kwon, Jonghwan Shin, So Hyun Paek, Sohee Oh
Pain scales employing faces are commonly used tools for assessing pain in children capable of communicating. However, some children require other types of pain scales since they have difficulties in understanding faces pain scales. The goal of this study was to develop and validate the "Pain Block" concrete ordinal scale for 4-7-year-old children. This was a multicenter prospective observational study in the Emergency Department. Psychometric properties (convergent validity, discriminative validity, responsivity, and reliability) were compared between the "Pain Block" pain scale and the Faces Pain Scale-Revised (FPS-R) to assess the validity of the "Pain Block" scale...
December 15, 2017: Pain
journal
journal
20321
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"