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https://www.readbyqxmd.com/read/29140930/attention-bias-modification-for-children-what-should-we-make-of-a-null-finding
#1
Louise Sharpe
No abstract text is available yet for this article.
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140929/tactile-acuity-dys-function-in-acute-nociceptive-low-back-pain-a-doubleblind-experiment
#2
Wacław M Adamczyk, Oskar Saulicz, Edward Saulicz, Kerstin Luedtke
Research shows that chronic pain is related to cortical alterations that can be reflected in reduced tactile acuity, but whether acute pain perception influences tactile acuity has not been tested. Considering the biological role of nociception, it was hypothesized that nociceptive pain will lead to a rapid improvement in tactile acuity and that this effect is correlated with pain intensity and pain distribution. In this randomised double-blind controlled experiment (trial no. NCT03021278), healthy participants were exposed to one of three experimental conditions: acute, nociceptive low back pain induced by saline injection, a sham-injection (without piercing the skin) potentially inducing nocebo pain, or no intervention...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140928/ngf-locally-sensitizes-nociceptors-in-human-skin
#3
Otilia Obreja, Roman Rukwied, Lorenz Nagler, Martha Schmidt, Martin Schmelz, Barbara Namer
Nerve growth factor (NGF) injected into human skin causes local hyperalgesia to mechanical and electrical stimuli lasting for weeks. Pig data suggested axonal sensitization of C-nociceptors as contributing mechanism. Here, we recorded single C- nociceptors in eleven human subjects 3 weeks after intracutaneous injection of 1 µg NGF into the foot dorsum. For each identified unit, the receptive field was mapped and, whenever possible, we recorded two terminal branches of the same unit, one from the hyperalgesic NGF-site ("inside") and the other from the non-sensitized skin ("outside")...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140927/clinical-trial-designs-and-models-for-analgesic-medications-for-acute-pain-in-neonates-infants-toddlers-children-and-adolescents-acttion-recommendations
#4
Gary A Walco, Ernest A Kopecky, Steven J Weisman, Jennifer Stinson, Bonnie Stevens, Paul J Desjardins, Charles B Berde, Elliot J Krane, Kanwaljeet Js Anand, Myron Yaster, Carlton D Dampier, Robert H Dworkin, Ian Gilron, Anne M Lynn, Lynne G Maxwell, Srinivasa Raja, Bernard Schachtel, Dennis C Turk
Clinical trials to test the safety and efficacy of analgesics across all pediatric age cohorts are needed to avoid inappropriate extrapolation of adult data to children. However, the selection of acute pain models and trial design attributes to maximize assay sensitivity, by pediatric age cohort, remains problematic. Acute pain models used for drug treatment trials in adults are not directly applicable to the pediatric age cohorts - neonates, infants, toddlers, children, and adolescents. Developmental maturation of metabolic enzymes in infants and children must be taken into consideration when designing trials to test analgesic treatments for acute pain...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140926/variability-in-negative-emotions-among-individuals-with-chronic-low-back-pain-relationships-with-pain-and-function
#5
James I Gerhart, John W Burns, Stephen Bruehl, David A Smith, Kristina M Post, Laura S Porter, Erik Schuster, Asokumar Buvanendran, Anne Marie Fras, Francis J Keefe
Chronic pain is associated with elevated negative emotions, and resources needed to adaptively regulate these emotions can be depleted during prolonged pain. Studies of links between pain, function and negative emotions in people with chronic pain, however, have focused almost exclusively on relationships among mean levels of these factors. Indexes that may reflect aspects of emotion regulation have typically not been analyzed. We propose that one index of emotion regulation is variability in emotion over time as opposed to average emotion over time...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140925/mobilization-of-cd4-t-lymphocytes-in-inflamed-mucosa-reduces-pain-in-colitis-mice-towards-a-vaccinal-strategy-to-alleviate-inflammatory-visceral-pain
#6
Lilian Basso, Jérôme Boué, Céline Augé, Céline Deraison, Catherine Blanpied, Nicolas Cenac, Philippe Lluel, Nathalie Vergnolle, Gilles Dietrich
T lymphocytes play a pivotal role in endogenous regulation of inflammatory visceral pain. The analgesic activity of T lymphocytes is dependent on their production of opioids, a property acquired upon antigen activation. Accordingly, we investigated whether an active recruitment of T lymphocytes within inflamed colon mucosa via a local vaccinal strategy may counteract inflammation-induced visceral pain in mice. Mice were immunized against ovalbumin (OVA). One month after immunization, colitis was induced by adding 3% (w/v) Dextran Sulfate Sodium (DSS) into drinking water containing either cognate antigen OVA or control antigen BSA for 5 days...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140924/the-association-between-pain-and-frailty-among-chinese-community-dwelling-older-adults-depression-as-a-mediator-and-its-interaction-with-pain
#7
Xiaoyu Tian, Cuili Wang, Xiaoxia Qiao, Na Liu, Lijuan Dong, Mary Butler, Huaxin Si, Yaru Jin
Pain and frailty are both prevalent and have severe health impacts among older adults. We conducted a cross-sectional observational study to examine the association between pain and frailty, and depression as a mediator and its interaction with pain on frailty among 1788 Chinese community-dwelling older adults. Physical frailty, pain intensity and depressive symptoms were assessed using the Frailty Phenotype, the revised Faces Pain Scale (FPS-R), and the 5-item Geriatric Depression Scale (GDS-5), respectively...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140923/il-4-mediates-the-analgesia-produced-by-low-intensity-exercise-in-mice-with-neuropathic-pain
#8
Franciane Bobinski, Juliana Maia Teixeira, Kathleen Anne Sluka, Adair Roberto Soares Santos
Peripheral nerve injury (PNI) activates the immune system resulting in increased pro-inflammatory cytokines at the site of injury and in the spinal cord dorsal horn. Exercise modulates the immune system promoting an anti-inflammatory phenotype of macrophages in uninjured muscle, and increases in anti-inflammatory cytokines can promote healing and analgesia. We proposed that PNI will decrease, and treadmill exercise will increase, release of anti-inflammatory cytokines at the site of injury and in the spinal cord...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29140922/fingolimod-reduces-neuropathic-pain-behaviors-in-a-mouse-model-of-multiple-sclerosis-by-a-sphingosine-1-phosphate-receptor-1-dependent-inhibition-of-central-sensitization-in-the-dorsal-horn
#9
Suzanne Doolen, Tommaso Iannitti, Benjamin C Shaw, Carolyn M Grachen, Renee R Donahue, Bradley K Taylor
Multiple sclerosis (MS) is an autoimmune-inflammatory neurodegenerative disease that is often accompanied by a debilitating neuropathic pain. Disease-modifying agents slow the progression of MS and prevent relapses, yet it remains unclear if they yield analgesia. We explored the analgesic potential of fingolimod (FTY720), an agonist/functional antagonist at the sphingosine-1-phosphate receptor 1 (S1PR1), because it reduces hyperalgesia in models of peripheral inflammatory and neuropathic pain. We used a myelin oligodendrocyte glycoprotein 35-55 (MOG35-55) mouse model of experimental autoimmune encephalomyelitis (EAE), modified to avoid frank paralysis and thus allow for assessment of withdrawal behaviors to somatosensory stimuli...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29112009/communication-about-chronic-pain-and-opioids-in-primary-care-impact-on-patient-and-physician-visit-experience
#10
Stephen G Henry, Robert A Bell, Joshua J Fenton, Richard L Kravitz
Patients and physicians report that communication about chronic pain and opioids is often challenging, but there is little empirical research on whether patient-physician communication about pain affects patient and physician visit experience. This study video recorded 86 primary care visits involving 49 physicians and 86 patients taking long-term opioids for chronic musculoskeletal pain, systematically coded all pain-related utterances during these visits using a custom-designed coding system, and administered pre- and post-visit questionnaires...
November 3, 2017: Pain
https://www.readbyqxmd.com/read/29112008/tlr4-deficiency-abrogated-widespread-tactile-allodynia-but-not-widespread-thermal-hyperalgesia-and-trigeminal-neuropathic-pain-following-partial-infraorbital-nerve-transection
#11
Ting-Ting Hu, Ran-Ran Wang, Ying-Ying Tang, Yu-Xing Wu, Jie Yu, Wei-Wei Hou, Guo-Dong Lou, Yu-Dong Zhou, Shi-Hong Zhang, Zhong Chen
Pain sensitization following partial infraorbital nerve transection (p-IONX) in mice not only presents in orofacial region, but also spreads to distant body parts. The roles of toll like receptor 4 (TLR4) in orofacial pain and the spreading process are still unclear. Here we found that mice with deficient TLR4 due to Tr4 gene point mutation (C3H/HeJ) or spontaneous deletion (C57BL/10ScNJ) developed tactile allodynia and thermal hyperalgesia in the vibrissal pad in a parallel way to their respective wild types (C3HeB/FeJ or C57BL/6J) following p-IONX...
November 3, 2017: Pain
https://www.readbyqxmd.com/read/29112007/trajectories-and-predictors-of-the-long-term-course-of-low-back-pain-cohort-study-with-5-year-follow-up
#12
Ying Chen, Paul Campbell, Victoria Y Strauss, Nadine E Foster, Kelvin P Jordan, Kate M Dunn
Low back pain (LBP) is a major health challenge globally. Research has identified common trajectories of pain over time. We aimed to investigate whether trajectories described in one primary care cohort can be confirmed in another, and to determine the prognostic value of factors collected 5 years prior to the identification of the trajectory. The study was carried out on 281 patients who had consulted primary care for LBP, at that point completed a baseline questionnaire, and then returned a questionnaire at 5-years follow-up plus at least 3 (of 6) subsequent monthly questionnaires...
November 3, 2017: Pain
https://www.readbyqxmd.com/read/29076920/vigilance-related-attention-systems-subserve-the-discrimination-of-relative-intensity-differences-between-painful-stimuli
#13
Sung-Ling Yang, Ting-Wei Wu, Ming-Tsung Tseng
Humans require the ability to discriminate intensities of noxious stimuli to avoid future harm. This discrimination process seems to be biased by an individual's attention to pain and involves modulation of the relative intensity differences between stimuli (ie, Weber fraction). Here, we ask whether attention networks in the brain modulate the discrimination process and investigate the neural correlates reflecting the Weber fraction for pain intensity. In a delayed discrimination task, participants differentiated the intensity of 2 sequentially applied stimuli after a delay interval...
October 31, 2017: Pain
https://www.readbyqxmd.com/read/28953194/guideline-recommended-vs-high-dose-long-term-opioid-therapy-for-chronic-noncancer-pain-is-associated-with-better-health-outcomes-data-from-a-representative-sample-of-the-german-population
#14
Winfried Häuser, Tino Schubert, Norbert Scherbaum, Thomas Tölle
Recent evidence-based guidelines for long-term opioid therapy (LTOT) for chronic noncancer pain (CNCP) have defined daily morphine equivalent doses (MEQ/d) that require particular caution. The recommendation for a threshold MEQ/d is based on North American studies that have demonstrated negative health outcomes associated with high-dose LTOT for CNCP. We have conducted a retrospective cross-sectional study using an anonymized German health claims database, including 4,028,618 persons insured by 69 German statutory health insurances, representative of age and sex for the German population in 2014...
October 31, 2017: Pain
https://www.readbyqxmd.com/read/29112535/tempo-spatial-discrimination-is-lower-for-noxious-stimuli-than-for-innocuous-stimuli
#15
Ken Steffen Frahm, Carsten Dahl Mørch, Ole Kæseler Andersen
The exteroceptive sensory system is responsible for sensing external stimuli in relation to time and space. The aim of this study was to investigate the tempo-spatial properties of the exteroceptive system using painful laser heat and non-painful mechanical touch stimulation.Thirteen healthy subjects were stimulated on the volar forearm using two paradigms: a continuous stimulation along a line on the skin and a 2-point stimulation. The line stimulations were delivered in both the distal and proximal direction with lengths of 25, 50, 75, and 100mm...
October 30, 2017: Pain
https://www.readbyqxmd.com/read/29112534/il1%C3%AE-inhibition-contributes-to-the-anti-nociceptive-effects-of-voluntary-exercise-on-ischemia-reperfusion-induced-hypersensitivity
#16
Jessica L Ross, Luis F Queme, Jordan E Lamb, Kathryn J Green, Zachary K Ford, Michael P Jankowski
Issues of peripheral circulation have been increasingly suggested as an underlying cause of musculoskeletal pain in many conditions, including sickle cell anemia and peripheral vascular disease. We have previously shown in our model of transient ischemia and reperfusion injury (I/R) of the forelimb that individual group III and IV muscle afferents display altered chemosensitivity and mechanical thresholds 1 d following injury. Functional alterations corresponded to increased evoked and spontaneous pain-related behaviors and decreased muscle strength and voluntary activity-all actions that echo clinical symptoms of ischemic myalgia...
October 30, 2017: Pain
https://www.readbyqxmd.com/read/29084050/opioid-therapy-and-persistent-pain-can-cognitive-behavioral-therapy-cbt-help
#17
Alyssa N Van Denburg, Jennifer Plumb Vilardaga, Rebecca A Shelby, Francis J Keefe
No abstract text is available yet for this article.
October 26, 2017: Pain
https://www.readbyqxmd.com/read/29084049/preschool-children-s-coping-responses-and-outcomes-in-the-vaccination-context-child-and-caregiver-transactional-and-longitudinal-relationships
#18
Lauren Campbell, Rebecca Pillai Riddell, Robert Cribbie, Hartley Garfield, Saul Greenberg
This paper, based on two companion studies, presents an in-depth analysis of preschooler coping with vaccination pain. Study 1 employed an autoregressive cross-lagged path model to investigate the dynamic and reciprocal relationships between young children's coping responses (how they cope with pain and distress) and coping outcomes (pain behaviors) at the preschool vaccination. Expanding on this analysis, Study 2 then modeled preschool coping responses and outcomes using both caregiver and child variables from the child's 12-month vaccination (n=548), preschool vaccination (n=302), and a preschool psychological assessment (n=172)...
October 26, 2017: Pain
https://www.readbyqxmd.com/read/29068872/dopaminergic-tone-does-not-influence-pain-levels-during-placebo-interventions-in-patients-with-chronic-neuropathic-pain
#19
Ina Skyt, Kurosh Moslemi, Cathrine Baastrup, Kasper Grosen, Fabrizio Benedetti, Gitte L Petersen, Donald D Price, Kathryn T Hall, Ted J Kaptchuk, Peter Svensson, Troels S Jensen, Lene Vase
Placebo effects have been reported in patients with chronic neuropathic pain. Expected pain levels and positive emotions are involved in the observed pain relief, but the underlying neurobiology is largely unknown. Patients with neuropathic pain are highly motivated for pain relief, and as motivational factors such as expectations of reward, as well as pain processing in itself, are related to the dopaminergic system, it can be speculated that dopamine release contributes to placebo effects in neuropathic pain...
October 23, 2017: Pain
https://www.readbyqxmd.com/read/29076921/eeg-and-meg-in-pain-research-current-state-and-future-perspectives
#20
Markus Ploner, Elisabeth S May
No abstract text is available yet for this article.
October 13, 2017: Pain
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