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Laura Mustonen, Tommi Aho MPsy, Hanna Harno, Reetta Sipilä, Tuomo Meretoja, Eija Kalso
Nerve injury during breast cancer surgery can cause neuropathic pain (NP). It is not known why some, but not all, patients develop chronic postsurgical neuropathic pain (CPSNP) after the same nerve injury. In the present study, we examined 251 breast cancer survivors with surgeon-verified intercostobrachial nerve (ICBN) resection to identify factors that associate with CPSNP. The patients were recruited from a previous study of 1000 women treated for breast cancer in 2006-2010. This enabled us to analyze preoperative factors that associate with future CPSNP...
September 17, 2018: Pain
Michael K Nicholas
No abstract text is available yet for this article.
September 17, 2018: Pain
Aimin Wu, Wenlan Dong, Shiwei Liu, Jason Pui Yin Cheung, Kenny Yat Hong Kwan, Xinying Zeng, Kai Zhang, Zhenyu Sun, Xiangyang Wang, Kenneth Man Chee Cheung, Maigeng Zhou, Jie Zhao
The aim of this work was to quantify the prevalence and years lived with disability (YLDs) caused by low back pain (LBP) in China from 1990 to 2016. Data from the GBD 2016 (Global Burden of Diseases, Injuries, and Risk Factors Study 2016) were used. We analyzed the age-sex-province-specific prevalence and YLDs for LBP of 33 provinces/regions in China. Comparisons were made with the data retrieved from the 1990 GBD study. We estimated that 5.45x10 individuals had LBP in 1990, which rose to 6.73x10 in 2016. The age-standardized prevalence of LBP decreased from 5...
September 17, 2018: Pain
David Borsook, Andrew M Youssef, Laura Simons, Igor Elman, Christopher Eccleston
It is well recognized that, despite similar pain characteristics, some people with chronic pain recover, whereas others do not. In this review, we discuss possible contributions and interactions of biological, social, and psychological perturbations that underlie the evolution of treatment-resistant chronic pain. Behavior and brain are intimately implicated in the production and maintenance of perception. Our understandings of potential mechanisms that produce or exacerbate persistent pain remain relatively unclear...
September 17, 2018: Pain
Melissa S O'Brien, Holly T A Philpott, Jason J McDougall
Joint neuropathic pain occurs in a subset of arthritis patients and lysophosphatidic acid (LPA) has been implicated as a mediator of joint neuropathy. The mechanism by which LPA promotes neuropathic pain is unknown but may be related to altered signalling of the voltage-gated sodium channel NaV1.8 located on nociceptors. Since arthritis and neuropathic pain are more prevalent in women, this study aimed to explore potential sex-differences in the development of LPA-induced joint neuropathy and whether NaV1.8 played a role in the associated neuropathic pain...
September 11, 2018: Pain
W Michael Hooten, Joanna M Biernacka, Travis G O'Brien, Julie M Cunningham, John L Black
Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the influence of COMT Val158Met on the likelihood and dose of opioid use in adults with chronic pain. Adults with chronic pain consecutively admitted to an outpatient pain rehabilitation program were recruited for study participation (N=298)...
September 11, 2018: Pain
Kevin N Alschuler, Anna L Kratz, Grant S Lipman, Brian J Krabak, Dave Pomeranz, Patrick Burns, Joshua Bautz, Claire Nordeen, Crystal Irwin, Mark P Jensen
An important and substantial body of literature has established that maladaptive and adaptive coping strategies significantly impact pain-related outcomes. This literature, however, is based primarily on populations with painful injuries and illnesses. Little is known about coping in individuals who experience pain in other contexts and whether coping impacts outcomes in the same way. In an effort to better understand pain coping in such contexts, the present study evaluated pain coping in ultramarathon runners, a population known to experience moderate levels of pain with minimal perceived negative effects...
September 7, 2018: Pain
Timothy B C Johnstone, Jennifer Y Xie, Chaoling Qu, David J Wasiak, Derk J Hogenkamp, Frank Porreca, Kelvin W Gee
Chronic neuropathic pain may be caused, in part, by loss of inhibition in spinal pain processing pathways due to attenuation of local GABAergic tone. Nociception and nocifensive behaviors are reduced after enhancement of tonically activated extrasynaptic GABAAR mediated currents by agonist ligands for δ subunit-containing GABAARs. However, typical ligands that target δ subunit-containing GABAARs are limited due to sedative effects at higher doses. We used the spinal nerve ligation (SNL) and gp120 models of experimental neuropathic pain to evaluate compound 2-261, a non-benzodiazepine (BZ) site positive allosteric modulator (PAM) of α4β3δ GABAARs optimized to be non-sedative by selective activation of β2/3 subunit-containing GABAARs over receptor subtypes incorporating β1 subunits...
September 7, 2018: Pain
Onur Annak, Tonio Heidegger, Carmen Walter, Ralf Deichmann, Ulrike Nöth, Onno Hansen-Goos, Ulf Ziemann, Jörn Lötsch
Non-invasive modulation of the activity of pain-related brain regions by means of transcranial magnetic stimulation promises an innovative approach at analgesic treatments. However, heterogeneous successes in pain modulation by setting reversible "virtual lesions" at different brain areas points at unresolved problems including the optimum stimulation site. The secondary somatosensory cortex (S2) has been previously identified to be involved in the perception of pain intensity differences. Therefore, impeding its activity should impede the coding of the sensory component of pain intensity, resulting in a flattening of the relationship between pain intensity and physical stimulus strength...
September 7, 2018: Pain
Kim Ja, Bosma Rl, Hemington Ks, Rogachov A, Osborne Nr, Cheng Jc, Oh J, Crawley Ap, Dunkley Bt, Davis Kd
Chronic pain is a common occurrence in multiple sclerosis (MS) that severely affects quality of life, but the underlying brain mechanisms related to these symptoms are unknown. Previous electroencephalography (EEG) studies have demonstrated a role of alpha and beta band power in pain processing. However, how and where these brain signals change in MS-related chronic pain is unknown. Here we used resting state magnetoencephalography (MEG) to examine regional spectral power in the dynamic pain connectome - including areas of the ascending nociceptive pathway, default mode network (DMN) and the salience network (SN) - in patients with chronic MS pain and in healthy controls...
September 3, 2018: Pain
Sheng-Jie Shiue, Ruey-Horng Rau, Han-Shiang Shiue, Yi-Wei Hung, Zhi-Xiang Li, Kuender D Yang, Jen-Kun Cheng
Nerve injury-induced neuropathic pain is difficult to treat. In this study, we used exosomes derived from human umbilical cord mesenchymal stem cell (UCMSC) as a cell-free therapy for nerve injury-induced pain in rats. Isolated UCMSC exosomes range in size from 30 to 160 nm and contain CD63, HSP60 and CD81 exosome markers. After L5/6 spinal nerve ligation surgery, single intrathecal injection of exosomes reversed nerve ligation-induced mechanical and thermal hypersensitivities of rat right hindpaw at initial and well-developed pain stages...
September 3, 2018: Pain
Brandon J Rea, Anne-Sophie Wattiez, Jayme S Waite, William C Castonguay, Chantel M Schmidt, Aaron M Fairbanks, Bennett R Robertson, Cameron J Brown, Bianca N Mason, Maria-Cristina Moldovan-Loomis, Leon F Garcia-Martinez, Pieter Poolman, Johannes Ledolter, Randy H Kardon, Levi P Sowers, Andrew F Russo
Migraine is the third most common disease in the world (behind dental caries and tension-type headache) with an estimated global prevalence of 15%, yet its etiology remains poorly understood. Recent clinical trials have heralded the potential of therapeutic antibodies that block the actions of the neuropeptide calcitonin gene-related peptide (CGRP) or its receptor to prevent migraine. Calcitonin gene-related peptide is believed to contribute to trigeminal nerve hypersensitivity and photosensitivity in migraine, but a direct role in pain associated with migraine has not been established...
September 1, 2018: Pain
Andrea Truini, Vincenza Spallone, Roberto Morganti, Stefano Tamburin, Giampietro Zanette, Angelo Schenone, Chiara De Michelis, Valeria Tugnoli, Valentina Simioni, Fiore Manganelli, Raffaele Dubbioso, Giuseppe Lauria, Roberta Lombardi, Stefano Jann, Luisa De Toni Franceschini, Solomon Tesfaye, Marco Fiorelli, Alessandra Spagnoli, Giorgio Cruccu
This cross-sectional multicentre study aimed at investigating frequency and features of painful diabetic polyneuropathyWe consecutively enrolled 816 patients attending hospital diabetic outpatient clinics. We first definitely diagnosed diabetic polyneuropathy and pure small-fibre polyneuropathy using clinical examination, nerve conduction study, and skin biopsy or quantitative sensory testing. Adhering to widely agreed criteria, we then identified neuropathic pain and diagnosed painful polyneuropathy using a combined approach of clinical examination and diagnostic testsOut of the 816 patients, 36% had a diabetic polyneuropathy associated with male gender, age and diabetes severity; 2...
August 29, 2018: Pain
David Buehlmann, Giovanna Diletta Ielacqua, Jael Xandry, Markus Rudin
Cancer-induced bone pain is abundant among advanced stage cancer patients and arises from a primary tumor in the bone or skeletal metastasis of common cancer types such as breast, lung or prostate cancer. Recently, antibodies targeting nerve growth factor (NGF) have been shown to effectively relieve neuropathic and inflammatory pain states in mice and in humans. While efficacy has been shown in mice on a behavioral level, effectiveness in preventing pain-induced functional rearrangements in the central nervous system has not been shown...
August 29, 2018: Pain
Joseph L Riley, Yenisel Cruz-Almeida, Roland Staud, Roger B Fillingim
This study examined the effects of inter-stimulus-interval (ISI) on heat-evoked temporal summation of second pain (TSSP) and tested whether greatest maintenance of TSSP would occur at longer ISIs in older adults. Several lines of evidence support that TSSP is associated with central sensitization and is centrally mediated. The participants were 198 community- dwelling adults divided into three age cohorts (18-39, 40-59; and 60-78 years of age). Six TSSP trials used a train of 10 contacts with a preheated probe that made repetitive contact with the volar forearm...
August 28, 2018: Pain
Shreya S Bellampalli, Yingshi Ji, Aubin Moutal, Song Cai, E M Kithsiri Wijeratne, Maria A Gandini, Jie Yu, Aude Chefdeville, Angie Dorame, Lindsey A Chew, Cynthia L Madura, Shizhen Luo, Gabriella Molnar, May Khanna, John M Streicher, Gerald W Zamponi, A A Leslie Gunatilaka, Rajesh Khanna
The Federal Pain Research Strategy recommended development of non-opioid analgesics as a top priority in its strategic plan to address the significant public health crisis and individual burden of chronic pain facing >100 million Americans. Motivated by this challenge, a natural product extracts library was screened and identified a plant extract that targets activity of voltage-gated calcium channels. This profile is of interest as a potential treatment for neuropathic pain. The active extract derived from the desert lavender plant native to southwestern United States, when subjected to bioassay-guided fractionation afforded three compounds identified as pentacyclic triterpenoids, betulinic acid (BA), oleanolic acid, and ursolic acid...
August 28, 2018: Pain
Flávia V Santa-Cecília, David W Ferreira, Rafaela M Guimaraes, Nerry T Cecilio, Miriam M Fonseca, Alexandre H Lopes, Marcela Davoli-Ferreira, Ricardo Kusuda, Guilherme R Souza, Ueli Nachbur, José C Alves-Filho, Mauro M Teixeira, Dario S Zamboni, Fernando Q Cunha, Thiago M Cunha
Neuropathic pain is one of the most important types of chronic pain. It is caused by neuronal damage. Clinical and experimental studies suggest a critical role for neuro-immune interactions in the development of neuropathic pain. Herein, we have shown that the cytoplasmic receptor Nod-like receptor-2, NOD2, and its adaptor-signaling molecule RIPK2, participate in the development of neuropathic pain after peripheral nerve injury (Spared nerve injury model). The activation of NOD2 signaling in peripheral macrophage mediates the development of neuropathic pain through the production of pro-nociceptive cytokines (TNF and IL-1β)...
August 28, 2018: Pain
Meggane Melchior, Pierre-Eric Juif, Géraldine Gazzo, Nathalie Petit-Demoulière, Virginie Chavant, Adrien Lacaud, Yannick Goumon, Alexandre Charlet, Vincent Lelièvre, Pierrick Poisbeau
Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important adaptive value but might be altered by early life stress (ELS), possibly contributing to its long-term consequences on pain responses and associated comorbidities. We tested this hypothesis using a rat model of neonatal maternal separation (NMS) known to induce long term consequences on several brain functions including chronic stress, anxiety, altered social behavior and visceral hypersensitivity...
August 28, 2018: Pain
Luke Grundy, Andelain Erickson, Ashlee Caldwell, Sonia Garcia-Caraballo, Grigori Rychkov, Andrea Harrington, Stuart M Brierley
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a prevalent, chronic bladder disorder that negatively impacts the quality of life for ∼5% of the western population. Hypersensitivity of mechanosensory afferents embedded within the bladder wall is considered a key component in mediating IC/BPS symptoms. Bladder infusion of voltage-gated sodium (NaV) channel blockers show clinical efficacy in treating IC/BPS symptoms, however, the current repertoire of NaV channels expressed by, and contributing to bladder afferent function is unknown...
August 27, 2018: Pain
Paulino Barragán-Iglesias, Jasper Kuhn, Guadalupe C Vidal-Cantú, Ana Belen Salinas-Abarca, Vinicio Granados-Soto, Gregory O Dussor, Zachary T Campbell, Theodore J Price
Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentrations between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these pathological concentrations are not known. Because MGO has been linked to diabetic neuropathic pain, which is prevalent and poorly treated, insight into this unsolved biomedical problem could lead to much needed therapeutics. Our experiments provide compelling evidence that ∼ 1 μM concentrations of MGO activate the integrated stress response (ISR) in IB4-positive nociceptors in the dorsal root ganglion (DRG) of mice in vivo and in vitro...
August 27, 2018: Pain
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