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Dara Bree, Dan Levy
Post-traumatic headache (PTH) is one of the most common, debilitating and difficult symptoms to manage after a traumatic head injury. While the mechanisms underlying PTH remain elusive, recent studies in rodent models suggest the potential involvement of calcitonin gene-related peptide (CGRP), a mediator of neurogenic inflammation, and the ensuing activation of meningeal mast cells (MCs), pro-algesic resident immune cells that can lead to the activation of the headache pain pathway. Here, we investigated the relative contribution of MCs to the development of PTH-like pain behaviors in a model of mild closed head injury (mCHI) in male rats...
January 7, 2019: Pain
Jennifer S Gewandter, Maria E Frazer, Xueya Cai, Valerie F Chiodo, Shirley A Rast, Michelle Dugan, Hudson A Carter, Redi Rahmani, Jonathan J Stone, John D Markman
Persistent pain after lumbar surgery (failed back surgery syndrome (FBSS)) remains a leading indication for chronic analgesia. However, no analgesics have proven efficacious for this condition. Although trials have evaluated gabapentinoids for chronic low back pain, none of these trials focused solely on FBSS. This randomized, double-blind cross-over trial evaluated the efficacy of gabapentin (1800mg/day) for FBSS. Eligible patients had a diagnosis of FBBS, an average daily pain score of at least 4 out of 10, a neuropathic pain component (indicated by the PainDetect), and reported at least half of their pain radiating in their lower extremity...
January 7, 2019: Pain
Hadas Nahman-Averbuch, Eric Leon, Benjamin M Hunter, Lili Ding, Andrew D Hershey, Scott W Powers, Christopher D King, Robert C Coghill
Inhibitory pain modulation has been reported to be deficient in adults across different types of chronic pain, including migraine. To determine if a similar phenomenon occurs in youth, we performed a quantitative sensory testing investigation in adolescents with migraine (N=19). These patients were compared to healthy adolescents with (Fam-His; N=20) or without (Healthy; N=29) a family history of migraine (e.g., first degree relative with migraine). Subjects were first familiarized with the stimuli and visual analog rating scales using graded noxious stimuli (0°C, 43-49°C range)...
January 7, 2019: Pain
Sutirtha Ray, Isabella Salzer, Mira T Kronschläger, Stefan Boehm
(245/250): Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over non-steroidal antiinflammatory drugs (NSAIDs) as it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless, inhibitory impact on these enzymes is claimed to contribute to paracetamols mechanisms of action which, therefore, remained controversial. Recently, the APAP metabolites N-arachidonoylaminophenol (AM404) and N-acetyl-p-benzoquinone imine (NAPQI) have been detected in the central nervous system after systemic APAP administration and were reported to mediate paracetamol effects...
December 28, 2018: Pain
Tania Del Rivero, Roman Fischer, Fan Yang, Kathryn A Swanson, John R Bethea
Tumor Necrosis Factor (TNF) is a proinflammatory cytokine, which is involved in physiological and pathological processes and has been found to be crucial for pain development. In the current study, we were interested in the effects of blocking TNFR1 signaling on neuropathic pain following peripheral nerve injury with the use of transgenic mice and pharmacological inhibition. We have previously shown that TNFR1 mice failed to develop neuropathic pain and depressive symptoms after chronic constriction injury (CCI)...
December 21, 2018: Pain
Adrián Pérez-Aranda, Laura Andrés-Rodríguez, Albert Feliu-Soler, Christian Núñez, Christian Stephan-Otto, María A Pastor-Mira, Sofía López-Roig, Cecilia Peñacoba, Elena P Calandre, Mahmoud Slim, Monika Salgueiro, Guillem Feixas, Juan V Luciano
The main objective of this study is to identify fibromyalgia syndrome (FMS) clusters using the Revised Fibromyalgia Impact Questionnaire (FIQR); and to examine whether the clusters differ in sociodemographic characteristics, clinical measures, direct and indirect costs, levels of inflammatory markers and brain morphometry. A hierarchical cluster analysis was performed to classify a large, pooled Spanish sample of patients with FMS (N= 947) using the FIQR as clustering variable. A latent profile analysis was subsequently conducted to confirm the optimal number of FMS clusters...
December 21, 2018: Pain
Shanaya Fischer, Jillian Vinall, Maria Pavlova, Susan Graham, Abbie Jordan, Jill Chorney, Nivez Rasic, James T Brookes, Monica Hoy, Warren K Yunker, Melanie Noel
Pediatric pain is common, and memory for it may be distressing and have long-lasting effects. Children who develop more negatively-biased memories for pain (i.e., recalled pain is higher than initial pain report) are at risk for worse future pain outcomes. In adolescent samples, higher child and parent catastrophic thinking about pain was associated with negatively biased memories for post-surgical pain. This study examined the influence of child and parent anxiety on the development of younger children's post-surgical pain memories...
December 21, 2018: Pain
Tine van de Donk, Marieke Niesters, Mikael A Kowal, Erik Olofsen, Albert Dahan, Monique van Velzen
In this experimental randomized placebo-controlled 4-way crossover trial, we explored the analgesic effects of inhaled pharmaceutical-grade cannabis in twenty chronic pain patients with fibromyalgia. We tested four different cannabis varieties with exact knowledge on their [INCREMENT]-tetrahydrocannabinol (THC), and cannabidiol (CBD) content: Bedrocan® (22.4 mg THC, < 1 mg CBD), Bediol® (13.4 mg THC, 17.8 mg CBD), Bedrolite® (18.4 mg CBD, < 1 mg THC) and a placebo variety without any THC or CBD. Following a single vapor inhalation, THC and CBD plasma concentrations, pressure and electrical pain thresholds, spontaneous pain scores and drug high were measured for 3 hours...
December 20, 2018: Pain
Sybille Kramer, Petra Baeumler, Christian Geber, Johannes Fleckenstein, Michael Simang, Laura Haas, Gabriel Schober, Florian Pfab, Rolf-Detlef Treede, Dominik Irnich
(249 WORDS): This prospective cohort study aimed to characterize the sensory profile during acute herpes zoster (AHZ) and to explore sensory signs, physical and psychosocial health as predictors for postherpetic neuralgia (PHN).Results of quantitative sensory testing (QST) of 74 AHZ patients at the affected and at distant contralateral control site were compared to a healthy control group (CG). Pain characteristics (NPSI, SES), physical functioning and psychosocial health aspects (PDI, SF-36, STAI) were assessed by questionnaires...
December 20, 2018: Pain
Yusuke Sakurai, Masahide Fujita, Shiori Kawasaki, Takao Sanaki, Takeshi Yoshioka, Kenichi Higashino, Soichi Tofukuji, Sosuke Yoneda, Tatsuya Takahashi, Ken Koda, Toshiyuki Asaki, Minoru Hasegawa, Yasuhide Morioka
(200 / 250 WORDS): Most advanced knee osteoarthritis (OA) patients experience chronic pain resistant to cyclooxygenase (COX) inhibitors. However, the cells and molecules involved in this advanced OA pain remain poorly understood. In this study, we developed a rat model of advanced knee OA by modification of the monoiodoacetate-induced OA pain model and examined involvement of synovial macrophages in advanced OA pain. COX inhibitors, such as celecoxib and naproxen, and a steroid were ineffective, but an opioid and anti-nerve growth factor (NGF) antibody were effective for pain management in the advanced OA model...
December 20, 2018: Pain
Katherine A Mifflin, Muhammad S Yousuf, Kevin C Thorburn, Jennifer Huang, Maria Elisa Pérez-Muñoz, Gustavo Tenorio, Jens Walter, Klaus Ballanyi, Paulina C Drohomyrecky, Shannon E Dunn, Bradley J Kerr
Multiple Sclerosis (MS) is an inflammatory, neurodegenerative autoimmune disease associated with sensory and motor dysfunction. Although estimates vary, ∼50% of patients with MS experience pain during their disease. The mechanisms underlying the development of pain are not fully understood and no effective treatment for MS related pain is available. Previous work from our laboratory demonstrated that voluntary exercise (wheel running) can reduce nociceptive behaviours at disease onset in female mice with experimental autoimmune encephalomyelitis (EAE), an animal model used to study the immunopathogenesis of MS...
December 11, 2018: Pain
Olav Magnus Fredheim, Svetlana Skurtveit, Marte Handal, Vidar Hjellvik
Chronic pain due to either surgery, radiotherapy or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic non-malignant pain, primarily with non-pharmacological strategies. Based on complete national data from the Cancer registry of Norway and the Norwegian prescription database the aim of this study was to compare the use of non-opioid analgesics, opioids and benzodiazepines ten years after cancer diagnosis in long-term cancer survivors and the age and gender adjusted general population...
December 7, 2018: Pain
Carrie Ritchie, Samantha A Hollingworth, Jacelle Warren, Michele Sterling
Medicine use as part of multimodal management for whiplash-associated disorders (WAD) is common: neck pain is the cardinal symptom, mental health conditions are common, and some individuals may have neurological signs and symptoms. Almost half of WAD individuals have on-going pain and disability. However, medicine use during acute and chronic recovery periods for WAD management is unknown. We analysed medicine use during acute (<12 weeks) and chronic (12 weeks - 2 years) post-injury periods in adults claiming compensation for WAD in the no-fault jurisdiction of Victoria, Australia (n=2871)...
December 7, 2018: Pain
Samantha M Meints, Ishtiaq Mawla, Vitaly Napadow, Jian Kong, Jessica Gerber, Suk-Tak Chan, Ajay D Wasan, Ted J Kaptchuk, Christina McDonnell, Junie Carriere, Bruce Rosen, Randy L Gollub, Robert R Edwards
Changes in central pain processing have been shown in patients with chronic low back pain (cLBP). We used quantitative sensory testing (QST) methods to identify differences in pain sensitization between patients with cLBP (N=167) and healthy controls (N=33). Results indicated that, compared to healthy pain-free controls, cLBP patients showed increased sensitivity and greater painful aftersensations for mechanical pressure and pin prick stimuli and lower tactile spatial acuity in the two-point discrimination task (ps<...
December 7, 2018: Pain
Luke Grundy, Andrea M Harrington, Ashlee Caldwell, Joel Castro, Vasiliki Staikopoulos, Vladimir P Zagorodnyuk, Simon J H Brookes, Nick J Spencer, Stuart M Brierley
Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic reflexes necessary for maintaining continence are coordinated with pathways involved in sensation. However, the relationship between spinal circuits involved with physiological and nociceptive signalling from the bladder have only been partially characterised. We used ex-vivo bladder afferent recordings to characterise mechanosensitive afferent responses to graded distension (0-60mmHg) and retrograde tracing from the bladder wall to identify central axon projections within the dorsal horn of the lumbosacral spinal cord...
December 5, 2018: Pain
Charles A Warwick, Leonid P Shutov, Andrew J Shepherd, Durga P Mohapatra, Yuriy M Usachev
The complement system significantly contributes to the development of inflammatory and neuropathic pain, but the underlying mechanisms are poorly understood. Recently, we identified the signaling pathway responsible for thermal hypersensitivity induced by the complement system component C5a. Here, we examine the mechanisms of another important action of C5a, induction of mechanical hypersensitivity. We found that intraplantar injection of C5a produced a dose-dependent mechanical sensitization, and that this effect was blocked by chemogenetic ablation of macrophages in both male and female mice...
November 29, 2018: Pain
Stéphane Northon, Nabi Rustamov, Mathieu Piché
Integration of nociceptive information is essential to produce adapted responses, in order to promote body integrity and survival. However, how the brain integrates nociceptive inputs from different body areas remains unknown. The aim of the present study was to examine the cortical integration of bilateral nociceptive inputs evoked by laser heat stimuli. Sixteen healthy volunteers (8 F, 8 M; age: 25.5 ± 4.3) were recruited to participate in one session during which painful laser stimuli were applied to their hands with two Nd:YAP laser systems...
November 29, 2018: Pain
Matthew C Mauck, JunMei Hu, Christopher Sefton, Robert A Swor, David A Peak, Jeffrey S Jones, Niels K Rathlev, David C Lee, Robert M Domeier, Phyllis L Hendry, Samuel A McLean
Obesity has been found to increase the risk of musculoskeletal pain (MSP) in other settings, but to our knowledge the influence of increased body mass index on pain outcomes after common trauma exposures such as motor vehicle collision (MVC) has not been assessed. In addition, obesity results in biomechanical changes, as well as physiologic changes including reduced hypothalamic pituitary adrenal (HPA) axis negative feedback inhibition, but mechanisms by which obesity may result in worse post-traumatic outcomes remain poorly understood...
November 29, 2018: Pain
Sigrid Juhl Lunde, Peter Vuust, Eduardo A Garza-Villarreal, Lene Vase
No abstract text is available yet for this article.
November 29, 2018: Pain
Iryna A Khasabova, Sergey G Khasabov, Julie K Olson, Megan L Uhelski, Amy H Kim, Alejandra M Albino-Ramírez, Chad L Wagner, Virginia S Seybold, Donald A Simone
Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a murine model of cisplatin-induced hyperalgesia, we determined whether a PPARγ synthetic agonist, pioglitazone, attenuated the development of neuropathic pain and identified underlying mechanisms. Cisplatin produced mechanical and cold hyperalgesia and decreased electrical thresholds of Aδ and C-fibers, which were attenuated by co-administration of pioglitazone (10 mg/kg, i.p.) with cisplatin. Anti-hyperalgesic effects of pioglitazone were blocked by the PPARγ antagonist T0070907 (10 mg/kg, i...
November 29, 2018: Pain
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