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Pain

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https://www.readbyqxmd.com/read/28221285/genome-wide-methylation-analysis-of-a-large-population-sample-shows-neurological-pathways-involvement-in-chronic-widespread-musculoskeletal-pain
#1
Gregory Livshits, Ida Malkin, Maxim B Freidin, Yudong Xia, Fei Gao, Jun Wang, Timothy D Spector, Alex MacGregor, Jordana T Bell, Frances M K Williams
Chronic widespread musculoskeletal pain (CWP), has a considerable heritable component, which remains to be explained. Epigenetic factors may contribute to and account for some of the heritability estimate. We analysed epigenome-wide methylation using MeDIPseq in whole blood DNA from 1708 monozygotic and dizygotic Caucasian twins having CWP prevalence of 19.9%. Longitudinally stable methylation bins (lsBINs), were established by testing repeated measurements conducted ≥3 years apart, n = 292. DNA methylation variation at lsBINs was tested for association with CWP in a discovery set of 50 monozygotic twin pairs discordant for CWP, and in an independent dataset (n = 1608 twins), and the results from the 2 samples were combined using Fisher method...
April 20, 2017: Pain
https://www.readbyqxmd.com/read/28328574/the-long-term-reliability-of-static-and-dynamic-quantitative-sensory-testing-in-healthy-individuals
#2
Anna Marcuzzi, Paul J Wrigley, Catherine M Dean, Roger Adams, Julia M Hush
Quantitative sensory tests (QSTs) have been increasingly used to investigate alterations in somatosensory function in a wide range of painful conditions. The interpretation of these findings is based on the assumption that the measures are stable and reproducible. To date, reliability of QST has been investigated for short test-retest intervals. The aim of this study was to investigate the long-term reliability of a multimodal QST assessment in healthy people, with testing conducted on 3 occasions over 4 months...
April 19, 2017: Pain
https://www.readbyqxmd.com/read/28426553/greater-fear-of-visceral-pain-contributes-to-differences-between-visceral-and-somatic-pain-in-healthy-women
#3
Laura Ricarda Koenen, Adriane Icenhour, Katarina Forkmann, Annika Pasler, Nina Theysohn, Michael Forsting, Ulrike Bingel, Sigrid Elsenbruch
This functional magnetic resonance imaging (fMRI) study addressed similarities and differences in behavioral and neural responses to experimental visceral compared to somatic pain stimuli and explored the contribution of fear of pain to differences between pain modalities. In N=22 healthy women, blood oxygen level-dependent (BOLD) responses to rectal distensions and cutaneous heat stimuli matched for perceived pain intensity. Fear of pain and pain unpleasantness were assessed before and after scanning. Visceral pain was more fear-evoking, more unpleasant, and trial-by-trial intensity ratings failed to habituate across trials (all interactions modality X time/trial: p<...
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28426552/altered-neural-responses-to-heat-pain-in-drug-na%C3%A3-ve-patients-with-parkinson-s-disease
#4
Katarina Forkmann, Wiebke Grashorn, Katharina Schmidt, Odette Fründt, Carsten Buhmann, Ulrike Bingel
Pain is a frequent but still neglected non-motor symptom of Parkinson's disease (PD). However, neural mechanisms underlying pain in PD are poorly understood. Here we explored whether the high prevalence of pain in PD might be related to dysfunctional descending pain control. Using fMRI we explored neural responses during the anticipation and processing of heat pain in 21 PD patients (Hoehn&Yahr I-III) and 23 healthy controls (HC). PD patients were naïve to dopaminergic medication in order to avoid confounding drug effects...
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28426551/changing-pain-expectations-the-role-of-social-context-and-communication
#5
Martien G S Schrooten, Steven J Linton
No abstract text is available yet for this article.
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28426550/neuropathic-pain-after-chronic-nerve-constriction-may-not-correlate-with-chloride-dysregulation-in-mouse-trigeminal-nucleus-caudalis-neurons
#6
Alberto Castro, Ying Li, Charles Raver, Ramesh Chandra, Radi Masri, Mary Kay Lobo, Asaf Keller
Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium% chloride transporter, KCC2, and with increases in neuronal excitability. Here, we test the hypothesis that similar changes occur in mice with neuropathic pain induced by chronic constriction injury of the trigeminal infraorbital nerve (CCI¬-ION). This model allows us to distinguish an acute pain phase (3-¬5 days after injury) from a persistent pain phase (12¬-14 days after CCI-¬ION)...
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28426549/patient-action-as-means-and-end-for-chronic-pain-care
#7
Mark D Sullivan, Kevin E Vowles
No abstract text is available yet for this article.
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28394828/rab7-a-novel-redox-target-that-modulates-inflammatory-pain-processing
#8
Wiebke Kallenborn-Gerhardt, Christine V Möser, Jana E Lorenz, Mirco Steger, Juliana Heidler, Reynir Scheving, Jonas Petersen, Lea Kennel, Cathrin Flauaus, Ruirui Lu, Aimee L Edinger, Irmgard Tegeder, Gerd Geisslinger, Heinrich Heide, Ilka Wittig, Achim Schmidtko
Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing. Recent data indicate that ROS can trigger specific redox-dependent signaling processes, but the molecular targets of ROS signaling in the nociceptive system remain largely elusive. Here, we performed a proteome screen for pain-dependent redox regulation using an OxICAT approach, thereby identifying the small GTPase Rab7 as a redox-modified target during inflammatory pain in mice...
April 7, 2017: Pain
https://www.readbyqxmd.com/read/28394854/a-role-for-nk-1-neurons-in-the-rostral-ventromedial-medulla-in-the-development-of-chronic-post-thoracotomy-pain
#9
Sergey G Khasabov, Jeffrey Chi-Fei Wang, Donald A Simone, Gary R Strichartz
Thoracotomy results in chronic post-operative pain (CPTP) in half of the cases. Earlier findings in rat models of persistent post-surgical pain suggest that spinal pathways are critical for pain onset but not its maintenance. Descending systems from the brain stem modulate nociceptive transmission in the spinal cord and contribute to persistent pain, but their role in chronic postoperative pain has not been studied. Here we ablated pronociceptive neurokinin-1 receptor (NK-1R)-expressing neurons in the rat rostral ventromedial medulla (RVM) to identify their role in CPTP...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28394853/targeting-bdnf-in-the-medial-thalamus-for-the-treatment-of-central-poststroke-pain-in-a-rodent-model
#10
Hsi-Chien Shih, Yung-Hui Kuan, Bai-Chung Shyu
Approximately 7-10% of patients develop a chronic pain syndrome after stroke. This chronic pain condition is called central poststroke pain (CPSP). Recent studies have observed an abnormal increase in the secretion of brain-derived neurotrophic factor (BDNF) in spinal cord tissue after spinal cord injury. An animal model of CPSP was established by an intra-thalamus injection of collagenase. Mechanical and thermal allodynia was induced after lesions of the thalamic ventral basal complex in rats. Four weeks after the injection, the number of neurons decreased, the number of astrocytes, microglia, and P2X4 receptors increased, and BDNF mRNA expression increased in the brain lesion area...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28394852/peripheral-inflammatory-pain-sensitisation-is-independent-of-mast-cell-activation-in-male-mice
#11
Douglas M Lopes, Franziska Denk, Kim I Chisholm, Tesha Suddason, Camille Durrieux, Matthew Thakur, Clive Gentry, Stephen B McMahon
The immune and sensory systems are known for their close proximity and interaction. Indeed, in a variety of pain states a myriad of different immune cells are activated and recruited, playing a key role in neuronal sensitisation. During inflammatory pain it is thought that mast cells (MC) are one of the immune cell types involved in this process, but so far the evidence outlining their direct effect on neuronal cells remains unclear. To clarify whether MC are involved in inflammatory pain states, we used a transgenic mouse line (Mctp5CreiDTR) in which MC could be depleted in an inducible manner by administration of diphtheria toxin...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28394851/development-and-validation-of-the-self-reported-promis-pediatric-pain-behavior-item-bank-and-short-form-scale
#12
Natoshia R Cunningham, Susmita Kashikar-Zuck, Constance Mara, Kenneth R Goldschneider, Dennis A Revicki, Carlton Dampier, David D Sherry, Lori Crosby, Adam Carle, Karon F Cook, Esi M Morgan
Pain behaviors are important indicators of functioning in chronic pain; however, no self-reported pain behavior instrument has been developed for pediatric populations. The purpose of this study was to create a brief pediatric measure of patient-reported pain behaviors as part of the Patient- Reported Outcome Measurement Information System (PROMIS). A pool of 47 candidate items for this measure had been previously developed through qualitative research. In this study, youth with chronic pain associated with juvenile fibromyalgia (JFM), juvenile idiopathic arthritis (JIA), or sickle cell disease (SCD) (ages 8 to 18 years) from three pediatric centers completed all 47 candidate items for development of the pain behavior item bank along with established measures of pain interference, depressive symptoms, fatigue, average pain intensity, and pain catastrophizing...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28394850/the-pain-course-a-randomised-controlled-trial-comparing-a-remotely-delivered-chronic-pain-management-program-when-provided-in-online-and-workbook-formats
#13
B F Dear, M Gandy, E Karin, T Ricciardi, V J Fogliati, S McDonald, L G Staples, K Nicholson Perry, L Sharpe, M K Nicholas, N Titov
The present study compared a remote-delivered pain management program, the Pain Course, when delivered in online and workbook formats. Participants (n = 178) were randomised to two groups: (1) an Internet Group (n = 84) who were provided with secure accounts to the program in an online format; or (2) a Workbook Group (n = 94) who were mailed workbook versions of the program. The content of both programs was identical and comprised 5 core lessons, which participants were encouraged to work through over an 8-week period, according to a prescribed timetable...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28383311/musculoskeletal-pain-profile-of-obese-individuals-attending-a-multidisciplinary-weight-management-service
#14
Grace A MacLellan, Colin Dunlevy, Emer O'Malley, Catherine Blake, Cathy Breen, Karen Gaynor, Natalie Wallace, Ruth Yoder, Domhnall Casey, John Mehegan, Donal O'Shea, Brona M Fullen
Obesity is associated with numerous chronic diseases, including musculoskeletal (MSK) pain, which impacts on quality of life (QoL). There is, however, limited research providing a comprehensive MSK pain profile of an obese cohort. This retrospective study utilized a patient database at a national weight management service (WMS). Following ethical approval, anonymized patient data were statistically analyzed to develop a pain profile, investigate relationships between pain, sleep, and function, and explore variables associated with having low back pain (LBP) and knee pain...
April 5, 2017: Pain
https://www.readbyqxmd.com/read/28420009/temporal-summation-and-motor-function-modulation-during-repeated-jaw-movements-in-patients-with-temporomandibular-disorder-pain-and-healthy-controls
#15
Yuanxiu Zhang, Sheng Shao, Jinglu Zhang, Lin Wang, Kelun Wang, Peter Svensson
Temporal summation of nociceptive inputs may be an important pathophysiological mechanism in temporomandibular disorders (TMD) pain; however, it remains unknown how natural jaw function relates to underlying pain mechanisms. This study evaluated changes in pain and movement patterns during repeated jaw movements in patients with painful temporomandibular joints (TMJ) compared with healthy controls. Twenty patients with TMD with TMJ pain, and an anterior disk displacement without reduction and 20 age- and gender-matched healthy volunteers were included...
March 31, 2017: Pain
https://www.readbyqxmd.com/read/28420008/c-reactive-protein-and-cold-pressor-tolerance-in-the-general-population-the-troms%C3%A3-study
#16
Elina Iordanova Schistad, Audun Stubhaug, Anne-Sofie Furberg, Bo Lars Engdahl, Christopher Sivert Nielsen
The aim of this study was to examine whether increases in severity of subclinical inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), increased experimental pain sensitivity, measured by cold-pressor tolerance, and to test whether this relationship is independent of chronic pain. A large population-based study from 2007 to 2008, the sixth Tromsø Study, provided data from 12,981 participants. For the present analysis, complete data for 10,274 participants (age: median 58 years) were available...
March 31, 2017: Pain
https://www.readbyqxmd.com/read/28221284/pain-interference-and-physical-function-demonstrate-poor-longitudinal-association-in-people-living-with-pain-a-promis-investigation
#17
Nicholas V Karayannis, John A Sturgeon, Ming Chih-Kao, Corinne Cooley, Sean C Mackey
A primary goal in managing pain is to reduce pain and increase physical function (PF). This goal is also tied to continuing payment for treatment services in many practice guidelines. Pain interference (PI) is often used as a proxy for measurement and reporting of PF in these guidelines. A common assumption is that reductions in PI will translate into improvement in PF over time. This assumption needs to be tested in a clinical environment. Consequently, we used the patient-reported outcomes measurement information system (PROMIS) to describe the topology of the longitudinal relationship between PI in relation to PF...
March 28, 2017: Pain
https://www.readbyqxmd.com/read/28195856/pharmacoepidemiologic-analyses-of-opioid-use-among-oef-oif-ond-veterans
#18
Teresa J Hudson, Jacob T Painter, Bradley C Martin, Mark A Austen, James S Williams, John C Fortney, Mark D Sullivan, Mark J Edlund
There is a great deal of concern about opioid use in veterans, particularly those who served in Afghanistan (OEF) and Iraq (OIF and OND). The current study provides a detailed pharmacoepidemiologic analysis of opioid use among OEF/OIF/OND veterans from FY09 to FY12. Data from 3 data repositories from the Veterans Health Administration (VHA) were used to describe demographic, clinical, and medication characteristics associated with opioid use among OEF/OIF/OND veterans and among those with TBI. Logistic regression models were used to identify risks associated with chronic opioid use in FY12...
March 25, 2017: Pain
https://www.readbyqxmd.com/read/28178074/a-common-pronociceptive-pain-modulation-profile-typifying-subgroups-of-chronic-pelvic-pain-syndromes-is-interrelated-with-enhanced-clinical-pain
#19
Keren Grinberg, Michal Granot, Lior Lowenstein, Liora Abramov, Irit Weissman-Fogel
Provoked vestibulodynia (PVD) and painful bladder syndrome (PBS), subgroups of chronic pelvic pain syndromes (CPPS), are considered to share common biophysiological peripheral mechanisms. In addition, indications of a pronociceptive pain profile coexisting with psychological vulnerability suggest common dysfunctional pain processing and pain modulation in these 2 subgroups of CPPS. We therefore aimed at comparing the pain profile and psychological traits of patients with PVD and PBS to see whether the pain profile contributes to intersubject variability of clinical pain symptoms...
March 24, 2017: Pain
https://www.readbyqxmd.com/read/28338566/midazolam-as-an-active-placebo-in-3-fentanyl-validated-nociceptive-pain-models
#20
Julian Prosenz, Burkhard Gustorff
The use of inactive placebos in early translational trials of potentially analgesic compounds is discouraged because of the side-effect profiles of centrally acting analgesics. Therefore, benzodiazepines are used, although their use has not been validated in this context. Whether benzodiazepines confound the results of acute pain tests is unknown. Midazolam (0.06 mg/kg) as an active placebo was investigated in 3 nociceptive models that included contact heat, electrical pain, and pressure pain thresholds in 24 healthy volunteers...
March 23, 2017: Pain
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