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https://www.readbyqxmd.com/read/28644822/the-effect-of-a-lay-led-group-based-self-management-program-for-patients-with-chronic-pain-a-randomized-controlled-trial-of-the-danish-version-of-the-chronic-pain-self-management-programme
#1
Mimi Mehlsen, Lea Hegaard, Eva Ørnbøl, Jens Søndergaard Jensen, Per Fink, Lisbeth Frostholm
The Stanford Chronic Pain Self-Management Programme (CPSMP) consists of six 2½-hour weekly workshops focusing on how to manage pain in daily life. The workshops are facilitated by two workshop leaders of whom at least one must suffer from a long-term pain condition. The program is highly structured and manualized. Only few controlled trials testing the effect of CPSMP exist.Enrolled in the study were 424 adults from 19 Danish municipalities, (72% women; age: 25-93 years) with pain of any etiology and great variation in pain history (0-50 yrs)...
June 22, 2017: Pain
https://www.readbyqxmd.com/read/28644196/cebranopadol-a-novel-first-in-class-analgesic-drug-candidate-first-experience-in-patients-with-chronic-low-back-pain-in-a-randomized-clinical-trial
#2
Annette Christoph, Marie-Henriette Eerdekens, Maurits Kok, Gisela Volkers, Rainer Freynhagen
Chronic low back pain (LBP) is a common condition, usually with involvement of nociceptive and neuropathic pain components, high economic burden and impact on quality of life. Cebranopadol is a potent, first-in-class drug candidate with a novel mechanistic approach, combining nociceptin/orphanin FQ peptide and opioid peptide receptor agonism. We conducted the first Phase II, randomized, doubleblind, placebo- and active-controlled trial, evaluating the analgesic efficacy, safety, and tolerability of cebranopadol in patients with moderate to severe chronic LBP with and without neuropathic pain component...
June 21, 2017: Pain
https://www.readbyqxmd.com/read/28621701/epigenetics-insights-into-chronic-pain-dna-hypomethylation-in-fibromyalgia-a-controlled-pilot-study
#3
Daniel Ciampi de Andrade, Mariana Maschietto, Ricardo Galhardoni, Gisele Gouveia, Thais Chile, Ana C Victorino Krepischi, Camila S Dale, André R Brunoni, Daniella C Parravano, Ana S Cueva Moscoso, Irina Raicher, Helena H S Kaziyama, Manoel J Teixeira, Helena P Brentani
To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured by transcranial magnetic stimulation. DNA from the peripheral blood of patients with FM (n = 24) and HC (n = 24) were assessed using the Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) in patients with FM displaying a nonrandom distribution in regions of the genome...
June 15, 2017: Pain
https://www.readbyqxmd.com/read/28541258/paclitaxel-induced-painful-neuropathy-is-associated-with-changes-in-mitochondrial-bioenergetics-glycolysis-and-an-energy-deficit-in-dorsal-root-ganglia-neurons
#4
Natalie A Duggett, Lisa A Griffiths, Sarah J L Flatters
Painful neuropathy is the major dose-limiting side effect of paclitaxel chemotherapy. Mitochondrial dysfunction and adenosine triphosphate (ATP) deficit have previously been shown in peripheral nerves of paclitaxel-treated rats, but the effects of paclitaxel in the dorsal root ganglia (DRGs) have not been explored. The aim of this study was to determine the bioenergetic status of DRG neurons following paclitaxel exposure in vitro and in vivo. Utilising isolated DRG neurons, we measured respiratory function under basal conditions and at maximal capacity, glycolytic function, and Adenosine diphosphate (ADP)/ATP levels at 3 key behavioural timepoints; prior to pain onset (day 7), peak pain severity and pain resolution...
June 15, 2017: Pain
https://www.readbyqxmd.com/read/28614190/non-histaminergic-and-mechanical-itch-sensitization-in-atopic-dermatitis
#5
H H Andersen, J Elberling, H Sølvsten, G Yosipovitch, L Arendt-Nielsen
Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Non-histaminergic neuronal itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that non-histaminergic neuronal sensitization contributes to itch in AD. Hence, we compared sensitivity to thermal, mechanical, and chemical pruritic stimuli in AD patients and controls. The study comprised 25 AD patients with chronic itch and 25 healthy controls...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28614189/a-dose-response-study-of-topical-allyl-isothiocyanate-mustard-oil-as-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation
#6
H H Andersen, S Lo Vecchio, P Gazerani, L Arendt-Nielsen
Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl-isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, 90%) and vehicle (paraffin) were applied for 5 min to 3x3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28614188/placebo-effects-of-a-sham-opioid-solution-a-randomized-controlled-study-in-patients-with-chronic-low-back-pain
#7
Regine Klinger, Ralph Kothe, Julia Schmitz, Sandra Kamping, Herta Flor
This study tested the experimental placebo effect in a group of chronic pain patients. Forty-eight patients suffering from chronic back pain participated in a randomized clinical trial that tested the efficacy of a sham opioid solution (NaCl) compared to an alleged neutral, completely inactive solution (NaCl). We shaped the placebo effect by two interventions: suggestion/instruction and conditioning. The patients were either told that the "solution reduces pain/improves physical capacity" or the "solution is neutral, a placebo"...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28614187/translational-pain-assessment-could-natural-animal-models-be-the-missing-link
#8
Mary P Klinck, Jeffrey S Mogil, Maxim Moreau, B Duncan X Lascelles, Paul A Flecknell, Thierry Poitte, Eric Troncy
Failure of analgesic drugs in clinical development is common. Along with the current "reproducibility crisis" in pain research, this has led some to question the use of animal models. Experimental models tend to comprise genetically homogeneous groups of young, male rodents in restricted and unvarying environments, and pain-producing assays that may not closely mimic the natural condition of interest. In addition, typical experimental outcome measures using thresholds or latencies for withdrawal may not adequately reflect clinical pain phenomena pertinent to human patients...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28614186/mir-34c-5p-functions-as-pronociceptive-microrna-in-cancer-pain-by-targeting-cav2-3-containing-calcium-channels
#9
Jagadeesh Gandla, Santosh Kumar Lomada, Jianning Lu, Rohini Kuner, Kiran Kumar Bali
Pathophysiological mechanisms underlying pain associated with cancer are poorly understood. microRNAs are a class of non-coding RNAs with emerging functional importance in chronic pain. In a genome-wide screen for microRNAs regulated in dorsal root ganglia (DRG) neurons in a mouse model of bone metastatic pain, we identified miR-34c-5p as a functionally important pronociceptive microRNA. Despite these functional insights and therapeutic potential for miR-34c-5p, its molecular mechanism of action in peripheral sensory neurons remains unknown...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28621704/sensitization-of-trpv1-and-trpa1-via-peripheral-mglur5-signaling-contributes-to-thermal-and-mechanical-hypersensitivity
#10
Kuniya Honda, Masamichi Shinoda, Masahiro Kondo, Kohei Shimizu, Hisashi Yonemoto, Katsuhiko Otsuki, Ryuta Akasaka, Akihiko Furukawa, Koichi Iwata
Peripheral tissue inflammation or injury causes glutamate release from nociceptive axons, keratinocytes and Schwann cells, resulting in thermal hypersensitivity. However, the detailed molecular mechanisms underlying glutamate-induced thermal hypersensitivity are unknown. The aim of this study was to clarify the involvement of peripheral transient receptor potential (TRP) ankyrin 1 (TRPA1), TRP vanilloid 1 (TRPV1) and protein kinase C epsilon (PKCε) in glutamate-induced pain hypersensitivity. The amount of glutamate in the facial tissue was significantly increased 3 days after facial CFA injection...
June 8, 2017: Pain
https://www.readbyqxmd.com/read/28621703/pain-sensation-in-human-osteoarthritic-knee-joints-is-strongly-enhanced-by-diabetes-mellitus
#11
Annett Eitner, Julia Pester, Franziska Vogel, Ivan Marintschev, Thomas Lehmann, Gunther O Hofmann, Hans-Georg Schaible
The major burden of knee joint osteoarthritis (OA) is pain. Since in elder patients diabetes mellitus is an important comorbidity of OA we explored whether the presence of diabetes mellitus has a significant influence on pain intensity at the end stage of knee OA, and we aimed to identify factors possibly related to changes of pain intensity in diabetic patients. In 23 diabetic and 47 non-diabetic OA patients undergoing total knee arthroplasty, we assessed the pain intensity before the operation using the "Knee injury and Osteoarthritis Outcome score" (KOOS)...
June 8, 2017: Pain
https://www.readbyqxmd.com/read/28621702/short-duration-physical-activity-prevents-the-development-of-activity-induced-hyperalgesia-through-opioid-and-serotoninergic-mechanisms
#12
Lucas V Lima, Josimari M DeSantana, Lynn A Rasmussen, Kathleen A Sluka, Lucas Vasconcelos Lima
Regular physical activity prevents development of chronic muscle pain through modulation of central mechanisms that involve rostral ventromedial medulla (RVM). We tested if pharmacological blockade or genetic deletion of mu-opioid receptors in physically active mice modulates excitatory and inhibitory systems in the RVM in an activity-induced hyperalgesia model. We examined response frequency to mechanical stimulation of the paw, muscle withdrawal thresholds, and expression of phosphorylation of the NR1 subunit of the NMDA receptor (p-NR1) and serotonin transporter (SERT) in the RVM...
June 8, 2017: Pain
https://www.readbyqxmd.com/read/28598902/child-and-parent-pain-catastrophizing-and-pain-from-pre-surgery-to-six-weeks-post-surgery-examination-of-cross-sectional-and-longitudinal-actor-partner-effects
#13
Kathryn A Birnie, Jill Chorney, Ron El-Hawary
Child and parent pain catastrophizing are reported preoperative risk factors for children's acute and persistent postsurgical pain. This study examined dyadic relations between child and parent pain catastrophizing and child and parent ratings of child pain prior to (M=4.01 days; 'baseline') and following surgery (M=6.5 weeks; 'acute follow-up'), as well changes in pain catastrophizing during this time in 167 youth (86% female; Mage=14.55 years) undergoing spinal fusion surgery and one parent (89% mothers)...
June 8, 2017: Pain
https://www.readbyqxmd.com/read/28595241/stratifying-patients-with-peripheral-neuropathic-pain-based-on-sensory-profiles-algorithm-and-sample-size-recommendations
#14
Jan Vollert, Christoph Maier, Nadine Attal, David L H Bennett, Didier Bouhassira, Elena K Enax-Krumova, Nanna B Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S Jensen, Walter Magerl, Juan D Ramirez, Andrew S C Rice, Sigrid Schuh-Hofer, Märta Segerdahl, Jordi Serra, Pallai R Shillo, Soeren Sindrup, Solomon Tesfaye, Andreas C Themistocleous, Thomas R Tölle, Rolf-Detlef Treede, Ralf Baron
In a recent cluster analysis, it has been shown that patients with peripheral neuropathic pain can be grouped into 3 sensory phenotypes based on quantitative sensory testing profiles, which are mainly characterized by either sensory loss, intact sensory function and mild thermal hyperalgesia and/or allodynia, or loss of thermal detection and mild mechanical hyperalgesia and/or allodynia. Here, we present an algorithm for allocation of individual patients to these subgroups. The algorithm is nondeterministic-ie, a patient can be sorted to more than one phenotype-and can separate patients with neuropathic pain from healthy subjects (sensitivity: 78%, specificity: 94%)...
June 7, 2017: Pain
https://www.readbyqxmd.com/read/28570482/targeting-the-s1p-s1pr1-axis-mitigates-cancer-induced-bone-pain-and-neuroinflammation
#15
Shaness A Grenald, Timothy M Doyle, Hong Zhang, Lauren M Slosky, Zhoumou Chen, Tally M Largent-Milnes, Sarah Spiegel, Todd W Vanderah, Daniela Salvemini
Metastatic bone pain is the single most common form of cancer pain, and persists as a result of peripheral and central inflammatory, as well as, neuropathic mechanisms. Here, we provide the first characterization of sphingolipid metabolism alterations in the spinal cord occurring during cancer-induced bone pain (CIBP). Following femoral arthrotomy and syngenic tumor implantation in mice, ceramides decreased with corresponding increases in sphingosine and the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P)...
May 31, 2017: Pain
https://www.readbyqxmd.com/read/28570481/the-relationship-of-sociodemographic-and-psychological-variables-to-chronic-pain-variables-in-a-low-income-population
#16
Andrea K Newman, Benjamin P Van Dyke, Calia A Torres, Jacob W Baxter, Joshua C Eyer, Shweta Kapoor, Beverly E Thorn
Chronic pain is a pervasive condition that is complicated by economic, educational, and racial disparities. This study analyzes key factors associated with chronic pain within an understudied and underserved population. The sample is characterized by a triple disparity with respect to income, education/literacy, and racial barriers that substantially increase the vulnerability to the negative consequences of chronic pain. The study examined the pre-treatment data of 290 participants enrolled in the Learning About My Pain (LAMP) trial, a randomized controlled comparative effectiveness trial of psychosocial interventions (Beverly Thorn, PI, PCORI Contract #941; clinicaltrials...
May 31, 2017: Pain
https://www.readbyqxmd.com/read/28570480/sequential-analysis-of-child-pain-behaviors-and-maternal-responses-an-observational-study
#17
Shelby Langer, Joan Romano, Jonathon Brown, Heather Nielson, Bobby Ou, Christina Rauch, Lirra Zullo, Rona L Levy
This laboratory-based study examined lagged associations between child pain behavior and maternal responses as a function of maternal catastrophizing (CAT). Mothers completed the parent version of the Pain Catastrophizing Scale. Children participated in a validated water ingestion procedure to induce abdominal discomfort with mothers present. Video-recordings of their interactions were edited into 30-second segments and coded by two raters for presence of child pain behavior, maternal solicitousness, and non-task conversation...
May 31, 2017: Pain
https://www.readbyqxmd.com/read/28570479/sensitization-of-c-fiber-nociceptors-in-mice-with-sickle-cell-disease-is-decreased-by-local-inhibition-of-anandamide-hydrolysis
#18
Megan L Uhelski, Kalpna Gupta, Donald A Simone
Chronic pain and hyperalgesia, as well as pain resulting from episodes of vasoocclusion, are characteristic features of sickle cell disease (SCD) and are difficult to treat. Since there is growing evidence that increasing local levels of endocannabinoids can decrease hyperalgesia, we examined the effects of URB597, a fatty acid amide hydrolase (FAAH) inhibitor which blocks the hydrolysis of the endogenous cannabinoid anandamide (AEA), on hyperalgesia and sensitization of cutaneous nociceptors in a humanized mouse model of SCD...
May 31, 2017: Pain
https://www.readbyqxmd.com/read/28557840/john-j-bonica-born-100-years-ago
#19
John D Loeser
No abstract text is available yet for this article.
May 23, 2017: Pain
https://www.readbyqxmd.com/read/28557839/validation-of-eq-5d-and-15d-in-the-assessment-of-healthrelated-quality-of-life-in-chronic-pain
#20
Pekka Vartiainen, Pekka Mäntyselkä, Tarja Heiskanen, Nora Hagelberg, Seppo Mustola, Heli Forssell, Hannu Kautiainen, Eija Kalso
Chronic pain has a significant impact on quality of life. Measurement of health-related quality of life (HRQoL) is essential in the assessment of pain management outcomes, but different instruments have produced varying results. We assessed the validity of two HRQoL instruments, EQ-5D and 15D, in patients with challenging chronic pain. 391 chronic non-cancer pain patients referred to tertiary pain clinics completed EQ-5D, 15D and a broad set of questionnaires mapping socioeconomic factors, self-rated health, pain intensity and interference, depression, pain acceptance, pain-related anxiety, and sleep...
May 23, 2017: Pain
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