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Pain

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https://www.readbyqxmd.com/read/29787472/a-randomised-placebo-controlled-clinical-trial-with-the-%C3%AE-2-3-5-subunit-selective-gabaa-positive-allosteric-modulator-pf-06372865-in-patients-with-chronic-low-back-pain
#1
Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock, David S Reynolds, Richard P Butt
The effect of PF-06372865, a subtype selective positive allosteric modulator (PAM) of the γ-aminobutyric acid type A (GABAA) receptor, on chronic low back pain was investigated in a randomised, placebo and active-controlled Phase 2 clinical trial. The parallel treatment group trial consisted of a 1 week single-blind placebo run in phase, followed by 4 weeks double-blind treatment. Patients were randomised to receive either PF-06372865, naproxen or placebo BID for 4 weeks. The primary endpoint was the numerical rating score (NRS) of low back pain intensity (LBPI) after 4 weeks of active treatment...
May 21, 2018: Pain
https://www.readbyqxmd.com/read/29787471/hemi-sensory-disturbances-in-patients-with-complex-regional-pain-syndrome
#2
Peter D Drummond, Philip M Finch, Frank Birklein, Michael Stanton-Hicks, Lone F Knudsen
Sensory disturbances often spread beyond the site of injury in complex regional pain syndrome (CRPS) but whether this applies equally to CRPS I and II, or changes across the course of the disease, is unknown. Establishing this is important, because different symptom profiles in CRPS I and II, or in acute versus chronic CRPS, might infer different pathophysiology and treatment approaches. To explore these questions, sensory disturbances were assessed in the limbs and forehead of 71 patients with CRPS I and 33 patients with CRPS II...
May 21, 2018: Pain
https://www.readbyqxmd.com/read/29781957/quantitative-sensory-testing-in-patients-with-migraine-a-systemic-review-and-meta-analysis
#3
Hadas Nahman-Averbuch, Tom Shefi, Victor J Schneider, Dan Li, Lili Ding, Christopher D King, Robert C Coghill
Quantitative sensory testing (QST) is widely used to assess somatosensory function by application of controlled stimuli across a variety of modalities. The aim of the present meta-analysis is to synthesize QST results across a wide array of studies of patients with migraine to identify the QST parameters that are reliably different between patients with migraine and healthy controls. In addition, we aimed to determine whether such differences vary according to stimulus location. A comprehensive literature search (up to January 2017) was conducted, which included studies comparing QST parameters between patients with migraine and healthy controls...
May 17, 2018: Pain
https://www.readbyqxmd.com/read/29781962/the-conceptual-complexity-of-gender-and-its-relevance-to-pain
#4
Katelynn E Boerner, Christine T Chambers, Jacqueline Gahagan, Edmund Keogh, Roger B Fillingim, Jeffrey S Mogil
No abstract text is available yet for this article.
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29781961/-from-ear-to-trunk-mri-reveals-referral-of-pain
#5
Julia Forstenpointner, Stephan Wolff, Patrick W Stroman, Olav Jansen, Stefanie Rehm, Ralf Baron, Janne Gierthmühlen
Referred and projecting pain can be observed in acute and chronic pain states. We present the case of a 69-year-old female patient with postherpetic neuralgia (PHN) in dermatome Th2/3 who reported that touching the ipsilateral earlap (dermatome C2) would enhance pain and dynamic mechanical allodynia (DMA) in the affected Th2/3-dermatome. The aim was to investigate possible underlying mechanisms of this phenomenon using the capsaicin experimental pain sensitization model, quantitative sensory testing (QST) and functional spinal and supraspinal MRI (fMRI)...
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29781960/a-peripherally-restricted-cannabinoid-1-receptor-agonist-as-a-novel-analgesic-in-cancer-induced-bone-pain
#6
Hong Zhang, Dominique M Lund, Haley A Ciccone, William D Staatz, Mohab M Ibrahim, Tally M Largent-Milnes, Herbert H Seltzman, Igor Spigelman, Todd W Vanderah
Many malignant cancers, including breast cancer, have a propensity to invade bones, leading to excruciating bone pain. Opioids are the primary analgesics used to alleviate this cancer-induced bone pain (CIBP) but are associated with numerous severe side effects, including enhanced bone degradation, which significantly impairs patients' quality of life. In contrast, agonists activating only peripheral CB1 receptors (CB1Rs) have been shown to effectively alleviate multiple chronic pain conditions with limited side effects, yet no studies have evaluated their role(s) in CIBP...
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29781959/involvement-of-the-vgf-derived-peptide-tlqp-62-in-nerve-injury-induced-hypersensitivity-and-spinal-neuroplasticity
#7
Alexander G J Skorput, Xijing Zhang, Jonathan J Waataja, Cristina D Peterson, Maureen S Riedl, Kelley F Kitto, Hai Truong, Cecilia Huffman, Stephen R Salton, Carolyn A Fairbanks, Christopher N Honda, Lucy Vulchanova
Neuroplasticity in the dorsal horn following peripheral nerve damage contributes critically to the establishment of chronic pain. The neurosecretory protein VGF (non-acronymic) is rapidly and robustly upregulated following nerve injury, and therefore peptides generated from it are positioned to serve as signals for peripheral damage. The goal of this project was to understand the spinal modulatory effects of the C-terminal VGF derived peptide TLQP-62 at the cellular level and gain insight into the function of the peptide in the development of neuropathic pain...
May 16, 2018: Pain
https://www.readbyqxmd.com/read/29762260/clinical-indications-associated-with-opioid-initiation-for-pain-management-in-ontario-canada-a-population-based-cohort-study
#8
Sachin V Pasricha, Mina Tadrous, Wayne Khuu, David N Juurlink, Muhammad M Mamdani, J Michael Paterson, Tara Gomes
Concerns over prescription opioids contributing to high levels of opioid use disorder and overdose have led policymakers and clinicians to seek means to reduce inappropriate and high-dose initial prescriptions. To inform such efforts, we sought to describe the clinical indications associated with opioid initiation and the characteristics of the initial prescriptions and patients through a retrospective population-based cohort study. Our cohort included Ontarians initiating prescription opioids for pain management between April 1, 2015, and March 31, 2016...
May 14, 2018: Pain
https://www.readbyqxmd.com/read/29757887/lidocaine-infusions-and-preventative-analgesia-can-the-answer-to-our-prayers-be-hiding-right-under-our-noses
#9
Mark C Bicket, Steven P Cohen
No abstract text is available yet for this article.
May 11, 2018: Pain
https://www.readbyqxmd.com/read/29757886/perioperative-lidocaine-infusions-for-the-prevention-of-chronic-post-surgical-pain-a-systematic-review-and-meta-analysis-of-efficacy-and-safety
#10
Martin Bailey, Tomas Corcoran, Stephan Schug, Andrew Toner
Chronic post-surgical pain (CPSP) occurs in 12% of surgical populations and is a high priority for perioperative research. Systemic lidocaine may modulate several of the pathophysiological processes linked to CPSP. This systematic review aims to identify and synthesize the evidence linking lidocaine infusions and CPSP.The authors conducted a systematic literature search of the major medical databases from inception until October 2017. Trials that randomized adults without baseline pain to perioperative lidocaine infusion or placebo were included if they reported on CPSP...
May 11, 2018: Pain
https://www.readbyqxmd.com/read/29781958/does-the-word-placebo-evoke-a-placebo-response
#11
Gary J Bennett
No abstract text is available yet for this article.
April 27, 2018: Pain
https://www.readbyqxmd.com/read/29781956/responses-to-the-sham-treatment-versus-expectancy-effects
#12
Luana Colloca
No abstract text is available yet for this article.
April 27, 2018: Pain
https://www.readbyqxmd.com/read/29746351/spinal-gabaa-receptors-for-pain-control-lost-in-translation
#13
Hanns Ulrich Zeilhofer, Elena Neumann, Gordon Munro
No abstract text is available yet for this article.
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29746350/endogenous-pain-modulation-in-chronic-orofacial-pain-a-systematic-review-and-meta-analysis
#14
Estephan J Moana-Filho, Alberto Herrero Babiloni, Nicole R Theis-Mahon
Abnormal endogenous pain modulation (EPM) was suggested as a potential mechanism for chronic pain, i.e., increased pain facilitation and/or impaired pain inhibition underlying symptoms manifestation. EPM function can be tested using psychophysical methods such as temporal summation of pain (TSP) and conditioned pain modulation (CPM), which assess pain facilitation and inhibition, respectively. Several studies have investigated EPM function in patients with non-paroxysmal orofacial pain (OFP) and reported mixed results...
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29746349/nalcn-channels-enhance-the-intrinsic-excitability-of-spinal-projection-neurons
#15
Neil C Ford, Dejian Ren, Mark L Baccei
Spinal projection neurons convey nociceptive signals to multiple brain regions including the parabrachial (PB) nucleus, which contributes to the emotional valence of pain perception. Despite the clear importance of projection neurons to pain processing, our understanding of the factors that shape their intrinsic membrane excitability remains limited. Here we investigate a potential role for the Na leak channel NALCN in regulating the activity of spino-PB neurons in the developing rodent. Pharmacological reduction of NALCN current (INALCN), or the genetic deletion of NALCN channels, significantly reduced the intrinsic excitability of lamina I spino-PB neurons...
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29708944/multivariate-machine-learning-distinguishes-cross-network-dynamic-functional-connectivity-patterns-in-state-and-trait-neuropathic-pain
#16
J C Cheng, A Rogachov, K S Hemington, A Kucyi, R L Bosma, M A Lindquist, R D Inman, K D Davis
Communication within the brain is dynamic. Chronic pain can also be dynamic, with varying intensities experienced over time. Little is known of how brain dynamics are disrupted in chronic pain, or relates to patients' pain assessed at various time-scales (e.g., short-term state versus long-term trait). Patients experience pain "traits" indicative of their general condition, but also pain "states" that vary day to day. Here, we used network-based multivariate machine learning to determine how patterns in dynamic and static brain communication are related to different characteristics and timescales of chronic pain...
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29708943/pain-as-a-threat-to-the-social-self-a-motivational-account
#17
Kai Karos, Amanda C de C Williams, Ann Meulders, Johan W S Vlaeyen
No abstract text is available yet for this article.
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29708942/a-bifunctional-biased-mu-opioid-agonist-neuropeptide-ff-receptor-antagonist-as-analgesic-with-improved-acute-and-chronic-side-effects
#18
Armand Drieu la Rochelle, Karel Guillemyn, Maria Dumitrascuta, Charlotte Martin, Valérie Utard, Raphaëlle Quillet, Séverine Schneider, François Daubeuf, Tom Willemse, Pieter Mampuys, Bert U W Maes, Nelly Frossard, Frédéric Bihel, Mariana Spetea, Frédéric Simonin, Steven Ballet
Opioid analgesics, such as morphine, oxycodone and fentanyl, are the cornerstones for treating moderate to severe pain. However, upon chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and dependence liability. Neuropeptide FF (NPFF) and its receptors (NPFF1R and NPFF2R) are recognized as an important pronociceptive system involved in opioid-induced hyperalgesia and analgesic tolerance. Herein, we report the design of multitarget peptidomimetic compounds that show high affinity binding to the mu opioid receptor (MOPr) and NPFFRs...
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29708941/high-fat-diet-exacerbates-postoperative-pain-and-inflammation-in-a-sex-dependent-manner
#19
Zongbin Song, Wenrui Xie, Judith A Strong, Temugin Berta, Yvonne M Ulrich-Lai, Qulian Guo, Jun-Ming Zhang
Obesity is often associated with increased pain, but little is known about the effects of obesity and diet on postoperative pain. In this study, effects of diet and obesity were examined in the paw incision model, a preclinical model of postoperative pain. Long-Evans rats were fed high-fat diet (40% calories from butter fat) or low-fat normal chow. Male rats fed high-fat diet starting 6 weeks prior to incision (a diet previously shown to induce markers of obesity) had prolonged mechanical hypersensitivity and an overall increase in spontaneous pain in response to paw incision, compared to normal chow controls...
April 26, 2018: Pain
https://www.readbyqxmd.com/read/29708940/chronic-pain-in-survivors-of-childhood-cancer-a-developmental-model-of-pain-across-the-cancer-trajectory
#20
Nicole M Alberts, Michelle M Gagnon, Jennifer N Stinson
No abstract text is available yet for this article.
April 26, 2018: Pain
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