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Pain Research & Management: the Journal of the Canadian Pain Society

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https://www.readbyqxmd.com/read/29770163/ultrasound-guided-prolotherapy-with-polydeoxyribonucleotide-for-painful-rotator-cuff-tendinopathy
#1
Kyoungho Ryu, Dongchan Ko, Goeun Lim, Eugene Kim, Sung Hyun Lee
Background: Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical regenerative injection that may be a viable treatment option. The objective of this study was to assess the efficacy of PDRN in the treatment of chronic rotator cuff tendinopathy...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29755622/serum-triamcinolone-levels-following-cervical-interlaminar-epidural-injection
#2
Tim J Lamer, Rozalin R Dickson, Halena M Gazelka, Wayne T Nicholson, Joel M Reid, Susan M Moeschler, W Michael Hooten
Background: Cervical interlaminar epidural steroid injections (ESIs) are commonly performed procedures to treat painful cervical radiculopathy, but little is known about the systemic absorption and serum levels of steroids following injection. The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided cervical epidural-administered triamcinolone acetonide in a cohort of patients with cervical radicular pain seeking treatment in a pain medicine clinic...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29755621/the-influence-of-expectation-on-nondeceptive-placebo-and-nocebo-effects
#3
Hua Wei, Lili Zhou, Huijuan Zhang, Jie Chen, Xuejing Lu, Li Hu
Nondeceptive placebo has demonstrated its efficiency in clinical practice. Although the underlying mechanisms are still unclear, nondeceptive placebo effect and nondeceptive nocebo effect may be mediated by expectation. To examine the extent to which expectation influences these effects, the present study compared nondeceptive placebo and nocebo effects with different expectation levels. Seventy-two healthy female participants underwent a standard conditioning procedure to establish placebo and nocebo effects...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29743962/a-comparative-study-between-transcutaneous-electrical-nerve-stimulation-and-fentanyl-to-relieve-shoulder-pain-during-laparoscopic-gynecologic-surgery-under-spinal-anesthesia-a-randomized-clinical-trail
#4
Zahra Asgari, Zahra Tavoli, Reihaneh Hosseini, Masoomeh Nataj, Fatemeh Tabatabaei, Fatemeh Dehghanizadeh, Hosein Haji-Amoo-Assar, Mahdi Sepidarkish, Ali Montazeri
Background: Traditionally, laparoscopic procedures have been performed under general anesthesia. Spinal anesthesia is an effective alternative to general anesthesia. However, one of the intraoperative complications of performing laparoscopic surgery under spinal anesthesia is shoulder pain. This study aimed to compare the effect of transcutaneous electrical nerve stimulation (TENS) with fentanyl on pain relief in patients who underwent gynecologic laparoscopy under spinal anesthesia. Methods: We conducted a prospective randomized clinical trial from May 2016 to March 2017...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29736198/optimism-positive-and-negative-affect-and-goal-adjustment-strategies-their-relationship-to-activity-patterns-in-patients-with-chronic-musculoskeletal-pain
#5
Rosa Esteve, Alicia E López-Martínez, Madelon L Peters, Elena R Serrano-Ibáñez, Gema T Ruiz-Párraga, Carmen Ramírez-Maestre
Objective: Activity patterns are the product of pain and of the self-regulation of current goals in the context of pain. The aim of this study was to investigate the association between goal management strategies and activity patterns while taking into account the role of optimism/pessimism and positive/negative affect. Methods: Two hundred and thirty-seven patients with chronic musculoskeletal pain filled out questionnaires on optimism, positive and negative affect, pain intensity, and the activity patterns they employed in dealing with their pain...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29686743/antinociceptive-activity-of-methanolic-extract-of-clinacanthus-nutans-leaves-possible-mechanisms-of-action-involved
#6
Zainul Amiruddin Zakaria, Mohammad Hafiz Abdul Rahim, Rushduddin Al Jufri Roosli, Mohd Hijaz Mohd Sani, Maizatul Hasyima Omar, Siti Farah Mohd Tohid, Fezah Othman, Siew Mooi Ching, Arifah Abdul Kadir
Methanolic extract of Clinacanthus nutans Lindau leaves (MECN) has been proven to possess antinociceptive activity that works via the opioid and NO-dependent/cGMP-independent pathways. In the present study, we aimed to further determine the possible mechanisms of antinociception of MECN using various nociceptive assays. The antinociceptive activity of MECN was (i) tested against capsaicin-, glutamate-, phorbol 12-myristate 13-acetate-, bradykinin-induced nociception model; (ii) prechallenged against selective antagonist of opioid receptor subtypes ( β -funaltrexamine, naltrindole, and nor-binaltorphimine); (iii) prechallenged against antagonist of nonopioid systems, namely, α 2 -noradrenergic (yohimbine), β -adrenergic (pindolol), adenosinergic (caffeine), dopaminergic (haloperidol), and cholinergic (atropine) receptors; (iv) prechallenged with inhibitors of various potassium channels (glibenclamide, apamin, charybdotoxin, and tetraethylammonium chloride)...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29682131/the-efficiency-of-anterior-repositioning-splints-in-the-management-of-pain-related-to-temporomandibular-joint-disc-displacement-with-reduction
#7
Malgorzata Pihut, Malgorzata Gorecka, Piotr Ceranowicz, Mieszko Wieckiewicz
Background and Objective: Intra-articular temporomandibular disorders are often related to pain in the area of the temporomandibular joint, ear, and temple. The aim of the study was to investigate the efficiency of anterior repositioning splints in decreasing pain related to temporomandibular joint disc displacement with reduction. Methods: The research material consisted of 112 patients, aged 24 to 45 years, of both genders, who reported for treatment at the Consulting Room of Temporomandibular Joint Dysfunctions at the Jagiellonian University in Cracow between 2014 and 2016 due to pain in the area of the temporomandibular joint(s) and noise(s) of temporomandibular joint(s) present during jaw movements with comorbid contracture of masticatory muscles...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29682130/-brave-men-and-emotional-women-a-theory-guided-literature-review-on-gender-bias-in-health-care-and-gendered-norms-towards-patients-with-chronic-pain
#8
REVIEW
Anke Samulowitz, Ida Gremyr, Erik Eriksson, Gunnel Hensing
Background: Despite the large body of research on sex differences in pain, there is a lack of knowledge about the influence of gender in the patient-provider encounter. The purpose of this study was to review literature on gendered norms about men and women with pain and gender bias in the treatment of pain. The second aim was to analyze the results guided by the theoretical concepts of hegemonic masculinity and andronormativity. Methods: A literature search of databases was conducted...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29682129/dentists-awareness-of-physical-therapy-in-the-treatment-of-temporomandibular-disorders-a-preliminary-study
#9
Inae C Gadotti, Corey Hulse, Julia Vlassov, Derek Sanders, Daniela A Biasotto-Gonzalez
Background: Physical therapy (PT) has been shown to be one of the most effective conservative treatments for temporomandibular disorders (TMD). Not all dentists are aware of the importance of the collaboration with physical therapists in the treatment of TMD pain. Objectives: To determine the awareness of dentists in Florida about the importance of PT for TMD pain and to create awareness related to collaborations. Methods: An online questionnaire was used...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29670678/the-underestimated-significance-of-conditioning-in-placebo-hypoalgesia-and-nocebo-hyperalgesia
#10
REVIEW
Anne-Kathrin Bräscher, Michael Witthöft, Susanne Becker
Placebo and nocebo effects are intriguing phenomena in pain perception with important implications for clinical research and practice because they can alleviate or increase pain. According to current theoretical accounts, these effects can be shaped by verbal suggestions, social observational learning, and classical conditioning and are necessarily mediated by explicit expectation. In this review, we focus on the contribution of conditioning in the induction of placebo hypoalgesia and nocebo hyperalgesia and present accumulating evidence that conditioning independent from explicit expectation can cause these effects...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29666666/early-factors-associated-with-the-development-of-chronic-pain-in-trauma-patients
#11
Raoul Daoust, Jean Paquet, Lynne Moore, Marcel Émond, Sophie Gosselin, Gilles Lavigne, Manon Choinière, Aline Boulanger, Jean-Marc Mac-Thiong, Jean-Marc Chauny
Objective: To identify factors, available at the time of trauma admission, associated with the development of chronic pain to allow testing of preventive approaches. Methods: In a retrospective observational cohort study, we included all patients ≥ 18 years old admitted for injury in 57 adult trauma centers in the province of Quebec (Canada) between 2004 and 2014. Chronic pain was defined as follows: treated in a chronic pain clinic, diagnosed with chronic pain, or received at least 2 prescriptions of chronic pain medications 3 to 12 months postinjury...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623148/diclofenac-potassium-in-acute-postoperative-pain-and-dysmenorrhoea-results-from-comprehensive-clinical-trial-reports
#12
REVIEW
R Andrew Moore, Sheena Derry
We compared the efficacy of diclofenac potassium in unpublished clinical study reports (CSRs) and published reports to examine publication bias, industry bias, and comprehensiveness. Novartis provided CSRs of randomised double-blind trials of diclofenac potassium involving postoperative patients following third molar extraction (3 trials, n =519), gynaecological surgery (3 trials, n =679), and dysmenorrhoea (2 trials, n =711) conducted in 1988-1990. Searches identified published reports of 6 trials. Information from 599/1909 patients was not published; trials with 846/1909 patients were published in a defunct journal...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623147/chronic-pain-in-inflammatory-arthritis-mechanisms-metrology-and-emerging-targets-a-focus-on-the-jak-stat-pathway
#13
REVIEW
Fausto Salaffi, Giovanni Giacobazzi, Marco Di Carlo
Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also "a disease itself." Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623146/low-back-pain-among-medical-students-in-belgrade-serbia-a-cross-sectional-study
#14
Isidora Vujcic, Nemanja Stojilovic, Eleonora Dubljanin, Nebojsa Ladjevic, Ivana Ladjevic, Sandra Sipetic-Grujicic
Aim: To examine the prevalence of low back pain, to identify self-perceived triggers of low back pain, and to investigate the impact of perceived pain on the daily activities and mood among medical students. Methods: This cross-sectional study enrolled 459 fourth year students at the Faculty of Medicine in Belgrade during December 2014. The anonymous questionnaire was used for data collection. In data analysis, the chi-square test and t -test were used. Results: The lifetime prevalence of low back pain was 75...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623145/water-soluble-polymer-assists-n-methyl-d-aspartic-acid-receptor-2b-sirna-delivery-to-relieve-chronic-inflammatory-pain-in-vitro-and-in-vivo
#15
Jie Peng, Jiahui Ma, Xue Yang, Huan He, Haopeng Wu, Tongtong Ma, Jianhua Lu
We constructed a water-soluble lipopolymer (WSLP) as a nonviral gene carrier to deliver siRNA targeting NR2B. The cytotoxicity and serum stability of WSLP loaded with siRNA were evaluated, and the knockdown efficiency of WSLP/NR2B-siRNA in PC12 cells was examined. The results showed that WSLP could protect the loading siRNAs from enzymatic degradation in serum and exhibit low cytotoxicity to cells. After transfection, WSLP/NR2B-siRNA complexes reduced the NR2B transcriptional level by 50% and protein level by 55% compared to control siRNA...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623144/accuracy-of-patient-opioid-use-reporting-at-the-time-of-medical-cannabis-license-renewal
#16
Jacob M Vigil, Sarah S Stith, Anthony P Reeve
The decision to authorize a patient for continued enrollment in a state-sanctioned medical cannabis program is difficult in part due to the uncertainty in the accuracy of patient symptom reporting and health functioning including any possible effects on other medication use. We conducted a pragmatic convenience study comparing patient reporting of previous and current prescription opioid usage to the opioid prescription records in the Prescription Monitoring Program (PMP) among 131 chronic pain patients (mean age = 54; 54% male) seeking the first annual renewal of their New Mexico Medical Cannabis Program (NMMCP) license...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623143/efficacy-of-nalbuphine-with-flurbiprofen-on-multimodal-analgesia-with-transverse-abdominis-plane-block-in-elderly-patients-undergoing-open-gastrointestinal-surgery-a-randomized-controlled-double-blinded-trial
#17
Yu Mao, Yuanyuan Cao, Bin Mei, Lijian Chen, Xuesheng Liu, Zhi Zhang, Erwei Gu
Objective: To assess different doses of nalbuphine with flurbiprofen compared to sufentanil with flurbiprofen in multimodal analgesia efficacy for elderly patients undergoing gastrointestinal surgery with a transverse abdominis plane block (TAPB). Methods: 158 elderly patients scheduling for elective open gastrointestinal surgery under general anesthesia and TAPB were randomly assigned to four groups according to different doses of nalbuphine with flurbiprofen in postoperative intravenous analgesia (PCIA)...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623142/chronic-pain-in-the-emergency-department-a-pilot-interdisciplinary-program-demonstrates-improvements-in-disability-psychosocial-function-and-healthcare-utilization
#18
Joshua A Rash, Patricia A Poulin, Yaadwinder Shergill, Heather Romanow, Jeffrey Freeman, Monica Taljaard, Guy Hebert, Ian G Stiell, Catherine E Smyth
Objective: To evaluate the feasibility of an individualized interdisciplinary chronic pain care plan as an intervention to reduce emergency department (ED) visits and improve clinical outcomes among patients who frequented the ED with concerns related to chronic pain. Methods: A prospective cohort design was used in an urban tertiary care hospital. As a pilot program, fourteen patients with chronic pain who frequented the ED (i.e., >12 ED visits within the last year, of which ≥50% were for chronic pain) received a rapid interdisciplinary assessment and individualized care plan that was uploaded to an electronic medical record system (EMR) accessible to the ED and patient's primary care provider...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29623141/functional-assessment-of-the-stomatognathic-system-after-the-treatment-of-edentulous-patients-with-different-methods-of-establishing-the-centric-relation
#19
Aleksandra Nitecka-Buchta, Thomas Proba, Paulina Proba, Kamil Stefański, Stefan Baron
The study compares subjective experiences of patients, wearing complete dentures. Two different methods of determining a centric relation were performed: the traditional method using wax occlusal rims and the Gerber method, based on gothic arch tracings. The success rate of establishing a centric relation in both methods was evaluated (rentgenodiagnostics). The influence of the method used to obtain the centric relation on patients' stomatognathic system (condyle centralization, pain) was also evaluated. Better results were achieved in gothic arch tracing method...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29610631/the-effect-of-propofol-on-chronic-headaches-in-patients-undergoing-endoscopy
#20
David Giampetro, Victor Ruiz-Velasco, Ashlee Pruett, Matthew Wicklund, Robert Knipe
Objective: This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background: Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a few days after the intervention has not been explored. Methods: We employed a nonrandomized, prospective observational study that recruited patients with chronic headaches who received propofol from an outpatient endoscopy center for either upper or lower endoscopies...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
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