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American Journal of Health-system Pharmacy: AJHP

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https://www.readbyqxmd.com/read/29903711/cost-effectiveness-analysis-of-initial-treatment-strategies-for-mild-to-moderate-clostridium-difficile-infection-in-hospitalized-patients
#1
Diana C Ford, Mary C Schroeder, Dilek Ince, Erika J Ernst
PURPOSE: The cost-effectiveness of initial treatment strategies for mild-to-moderate Clostridium difficile infection (CDI) in hospitalized patients was evaluated. METHODS: Decision-analytic models were constructed to compare initial treatment with metronidazole, vancomycin, and fidaxomicin. The primary model included 1 recurrence, and the secondary model included up to 3 recurrences. Model variables were extracted from published literature with costs based on a healthcare system perspective...
June 14, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29903710/analysis-of-drug-drug-interactions-among-patients-receiving-antiretroviral-regimens-using-data-from-a-large-open-source-prescription-database
#2
Nimish Patel, Peter Borg, Richard Haubrich, Ian McNicholl
PURPOSE: Results of a study of contraindicated concomitant medication use among recipients of preferred antiretroviral therapy (ART) regimens are reported. METHODS: A retrospective study was conducted to evaluate concomitant medication use in a cohort of previously treatment-naive, human immunodeficiency virus (HIV)-infected U.S. patients prescribed preferred ART regimens during the period April 2014-March 2015. Data were obtained from a proprietary longitudinal prescription database; elements retrieved included age, sex, and prescription data...
June 14, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29903709/ashp-national-survey-of-pharmacy-practice-in-hospital-settings-dispensing-and-administration-2017
#3
Philip J Schneider, Craig A Pedersen, Douglas J Scheckelhoff
PURPOSE: The results of the 2017 ASHP national survey of pharmacy practice in hospital settings are described. METHODS: Pharmacy directors at 4,828 general and children's medical- surgical hospitals in the United States were surveyed using a mixed-mode method of contact by mail and e-mail. Survey completion was online, using Qualtrics (Qualtrics, Provo, UT). IMS Health supplied data on hospital characteristics; the survey sample was drawn from the IMS hospital database (IMS Health, Yardley, PA)...
June 14, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29895521/physical-compatibility-of-plazomicin-with-select-i-v-drugs-during-simulated-y-site-administration
#4
Tomefa E Asempa, Lindsay M Avery, James M Kidd, Joseph L Kuti, David P Nicolau
PURPOSE: The results of a study to determine the physical compatibility of plazomicin sulfate solution during simulated Y-site administration with 92 i.v. drugs are reported. METHODS: Plazomicin injection solution (500 mg/10 mL) was diluted in 0.9% sodium chloride or 5% dextrose for injection to a final volume of 50 mL (final plazomicin concentration, 24 mg/mL), consistent with a 15-mg/kg dose administered to an 80-kg patient (i.e., 1,200 mg). All other i.v. drugs were reconstituted according to manufacturers' recommendations and diluted with 0...
June 12, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29895520/clinical-update-on-thrombolytic-use-in-pulmonary-embolism-a-focus-on-intermediate-risk-patients
#5
Hannah Eberle, Raquel Lyn, Tamara Knight, Emily Hodge, Mitchell Daley
PURPOSE: Current literature on clinical controversies surrounding the use of thrombolytic agents in patients with intermediate-risk pulmonary embolism (PE) is reviewed. SUMMARY: PE is a major cause of morbidity and mortality. When used in conjunction with anticoagulation, thrombolysis has been shown to reduce hemodynamic decompensation in select patients, but thrombolytic therapy is associated with high risks of bleeding and intracranial hemorrhage and its role in treating patients with intermediate-risk PE remains controversial...
June 12, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29895519/a-rare-fungus-on-the-rise-candida-auris
#6
Yuman Lee, Hongkai Bao, Sagar Viramgama
PURPOSE: An overview of the growing health threat posed by the fungus Candida auris is provided, including a review of the literature and Centers for Disease Control and Prevention recommendations on C. auris identification, treatment, and infection control. SUMMARY: Since C. auris was first identified in Japan in 2009, cases of C. auris infection have been on the rise in several parts of the world, including the United States, where the first case was reported in 2017; as of November 2017, a total of 206 U...
June 12, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29895518/disseminated-cryptococcosis-associated-with-administration-of-eculizumab
#7
Megan Clancy, Ryan McGhan, Jeremy Gitomer, Ana Marie Inocencio, Christina Aldrich, Roberto Iaderosa, Ryan Stevens
PURPOSE: A case report of fatal disseminated cryptococcosis in a patient treated with eculizumab is presented along with a review of literature suggesting a possible etiologic mechanism. SUMMARY: A 23-year-old man with a history of minimal change nephrotic syndrome was hospitalized for acute kidney injury and abdominal pain and swelling. He was found to have disseminated pneumococcal disease, including peritonitis, bacteremia, and pulmonic endocarditis. The patient developed evidence of microangiopathic hemolytic anemia, leading to a diagnosis of atypical hemolytic uremic syndrome, and was started on eculizumab...
June 12, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29844135/identifying-opportunities-to-advance-practice-at-a-large-academic-medical-center-using-the-ashp-ambulatory-care-self-assessment-tool
#8
Amber Lanae Martirosov, Angela Michael, Melissa McCarty, Opal Bacon, John R DiLodovico, Arin Jantz, Diana Kostoff, Nancy C MacDonald, Nancy Mikulandric, Klodiana Neme, Nimisha Sulejmani, Bryant B Summers
PURPOSE: The use of the ASHP Ambulatory Care Self-Assessment Tool to advance pharmacy practice at 8 ambulatory care clinics of a large academic medical center is described. SUMMARY: The ASHP Ambulatory Care Self-Assessment Tool was developed to help ambulatory care pharmacists assess how their current practices align with the ASHP Practice Advancement Initiative. The Henry Ford Hospital Ambulatory Care Advisory Group (ACAG) opted to use the "Practitioner Track" sections of the tool to assess pharmacy practices within each of 8 ambulatory care clinics individually...
May 29, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29789318/impact-of-a-pharmacist-physician-collaborative-care-model-on-patient-outcomes-and-health-services-utilization
#9
Gary R Matzke, Leticia R Moczygemba, Karen J Williams, Michael J Czar, William T Lee
PURPOSE: The impact of a pharmacist-physician collaborative care model on patient outcomes and health services utilization is described. METHODS: Six hospitals from the Carilion Clinic health system in southwest Virginia, along with 22 patient-centered medical home (PCMH) practices affiliated with Carilion Clinic, participated in this project. Eligibility criteria included documented diagnosis of 2 or more of the 7 targeted chronic conditions (congestive heart failure, hypertension, hyperlipidemia, diabetes mellitus, asthma, chronic obstructive pulmonary disease, and depression), prescriptions for 4 or more medications, and having a primary care physician in the Carilion Clinic health system...
May 22, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29789317/nonprescription-availability-of-the-opioid-antagonist-naloxone
#10
Allison Landers
No abstract text is available yet for this article.
May 22, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29789316/oral-ivermectin-for-the-treatment-of-head-lice-infestation
#11
REVIEW
Wendy L Sanchezruiz, Donald S Nuzum, Samir A Kouzi
PURPOSE: Published literature describing the use of oral ivermectin for the treatment of head lice infestation is reviewed. SUMMARY: In the United States and globally, head lice infestation, or pediculosis capitis, remains a public health issue with both social and medical implications. Treatment with oral or topical medications is typically required for head lice eradication. Resistance to traditional topical therapies for head lice infestation is increasing, creating a need for consideration of additional treatment options...
May 22, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29759975/restoring-the-switch-for-cancer-cell-death-targeting-the-apoptosis-signaling-pathway
#12
REVIEW
Clement Chung
PURPOSE: The relevance of apoptosis to cancer development and pharmacologic agents that target this pathway in selected malignancies are described. SUMMARY: Apoptosis is a tightly regulated biological process mediated by both proapoptotic (i.e., prodeath) and antiapoptotic (i.e., prosurvival) proteins. While apoptosis represents a well-established effector mechanism induced by conventional chemotherapy in many malignancies, the development of apoptosis-based targeted therapy is relatively new...
May 14, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29752256/promoting-integration-of-pharmacy-expertise-in-care-of-hospitalized-patients-with-acute-myocardial-infarction
#13
Leslie A Curry, Marie A Brault, Emily Cherlin, Marie Smith
PURPOSE: The substantive integration of pharmacists into quality-improvement initiatives aimed at improving the care of hospitalized patients with acute myocardial infarction (AMI) is described. METHODS: A 2-year, mixed-methods, interventional study was conducted in 10 U.S. hospitals, directed at promoting the use of evidence-based strategies and fostering domains of hospital organizational culture associated with lower risk-standardized mortality rates (RSMRs) for patients with AMI...
May 11, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29748254/national-trends-in-prescription-drug-expenditures-and-projections-for-2018
#14
Glen T Schumock, JoAnn Stubbings, Michelle D Wiest, Edward C Li, Katie J Suda, Linda M Matusiak, Robert J Hunkler, Lee C Vermeulen
PURPOSE: Historical trends and factors likely to influence future pharmaceutical expenditures are discussed, and projections are made for drug spending in 2018 in nonfederal hospitals, clinics, and overall (all sectors). METHODS: Drug expenditure data through calendar year 2017 were obtained from the IQVIA (formerly QuintilesIMS) National Sales Perspectives database and analyzed. New drug approvals, patent expirations, and other factors that may influence drug spending in hospitals and clinics in 2018 were also reviewed...
May 10, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29735612/signal-detection-for-bleeding-associated-with-the-use-of-direct-oral-anticoagulants
#15
Kobi T Nathan, Kelly M Conn, Robbert P van Manen, Jack E Brown
PURPOSE: The potential link between serious or life-threatening bleeding and the use of direct oral anticoagulants (DOACs) was evaluated. METHODS: Qualitative and quantitative reviews of case reports of bleeding events involving dabigatran, rivaroxaban, apixaban, edoxaban, and warfarin through March 31, 2017, were performed. A disproportionality analysis was conducted for each DOAC using an empirical Bayesian approach based on the relative reporting rate. Subanalyses were performed to assess (1) bleeding events (including mortality and life-threatening events) associated with DOACs among all adverse-event reports and (2) warfarin-related bleeding events...
May 7, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29728356/necessity-for-a-pathway-for-high-alert-patients
#16
Rita Shane, Kallie Amer, Lydia Noh, Donna Luong, Steve Simons
No abstract text is available yet for this article.
May 4, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29695484/illinois-hospitals-cope-with-outbreak-of-bleeding-linked-to-tainted-cannabinoids
#17
Kate Traynor
No abstract text is available yet for this article.
April 25, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29880527/noninferiority-studies-not-inherently-unethical
#18
Madeline McCarren, Todd P Semla
No abstract text is available yet for this article.
June 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29880526/are-noninferiority-studies-ethically-inferior
#19
Mark A Graber, John Ely, Brett A Faine
No abstract text is available yet for this article.
June 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29880525/development-of-a-standardized-citywide-process-for-managing-smart-pump-drug-libraries
#20
Todd A Walroth, Shannon Smallwood, Karen Arthur, Betsy Vance, Alana Washington, Therese Staublin, Tammy Haslar, Jennifer G Reddan, James Fuller
PURPOSE: Development and implementation of an interprofessional consensus-driven process for review and optimization of smart-pump drug libraries and dosing limits are described. SUMMARY: The Indianapolis Coalition for Patient Safety (ICPS), which represents 6 Indianapolis-area health systems, identified an opportunity to reduce clinically insignificant alerts that smart infusion pumps present to end users. Through a consensus-driven process, ICPS aimed to identify best practices to implement at individual hospitals in order to establish specific action items for smart-pump drug library optimization...
June 15, 2018: American Journal of Health-system Pharmacy: AJHP
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