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American Journal of Health-system Pharmacy: AJHP

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https://www.readbyqxmd.com/read/27895055/role-of-agents-for-reversing-the-effects-of-target-specific-oral-anticoagulants
#1
REVIEW
Tanya R Riley, Mary L Gauthier-Lewis, Chelsea K Sanchez, Janine S Douglas
PURPOSE: The available clinical data on target-specific oral anticoagulant (TSOAC) reversal agents that are currently in development or have been approved by the Food and Drug Administration (FDA) are reviewed. SUMMARY: The development of TSOACs such as dabigatran, rivaroxaban, edoxaban, and apixaban has presented benefits and new challenges. One of the main challenges associated with the use of TSOACs is the lack of suitable agent-specific reversal agents. Several treatment options for the management of life-threatening bleeding events associated with TSOAC use, such as fresh frozen plasma, prothrombin complex concentrates, and recombinant coagulation factor VIIa, have been used, with inconsistent results...
November 28, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27879233/ashp-research-and-education-foundation-s-pharmacy-forecast-an-essential-resource-for-pharmacy-practice
#2
EDITORIAL
Stephen J Allen
No abstract text is available yet for this article.
November 22, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27879232/ashp-foundation-pharmacy-forecast-2017-strategic-planning-advice-for-pharmacy-departments-in-hospitals-and-health-systems
#3
Stephen J Allen, William A Zellmer, Scott J Knoer, Pamela K Phelps, Kevin C Marvin, Andy Pulvermacher, James M Hoffman, Edward Li, Rita Shane, Linda S Tyler, Erin R Fox, Douglas J Scheckelhoff, William A Zellmer, Brian M Meyer
No abstract text is available yet for this article.
November 22, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27806938/meta-analysis-of-ascorbic-acid-for-prevention-of-postoperative-atrial-fibrillation-after-cardiac-surgery
#4
William L Baker, Craig I Coleman
PURPOSE: Results of a systematic review and meta-analysis of published data on use of ascorbic acid to prevent postoperative atrial fibrillation (POAF) after cardiac surgery are presented. METHODS: MEDLINE and other sources were searched for reports on trials evaluating the effects of preoperative and/or postoperative use of ascorbic acid in patients undergoing cardiac surgery. For each study selected for meta-analysis, an assessment for risks of methodological bias was performed...
November 2, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27806937/evaluation-of-a-protocol-to-optimize-duration-of-pneumonia-therapy-at-hospital-discharge
#5
Christina Caplinger, Kendall Crane, Michelle Wilkin, Jefferson Bohan, Richard Remington, Karl Madaras-Kelly
PURPOSE: A protocol to optimize the duration of antimicrobial therapy (DAT) for uncomplicated pneumonia at hospital discharge was evaluated. METHODS: This retrospective quasiexperimental study was conducted at Boise Veterans Affairs Medical Center from March 2013 through June 2015. Patients were included in the study if they were diagnosed with pneumonia, were hospitalized for more than 24 hours, received antimicrobial treatment within 48 hours of admission, and survived until hospital discharge...
November 2, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27784662/pharmacogenomics-to-achieve-precision-medicine
#6
EDITORIAL
Philip E Empey
No abstract text is available yet for this article.
October 26, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27784661/the-promise-of-precision-medicine-for-health-systems
#7
EDITORIAL
Stephen D Shapiro
No abstract text is available yet for this article.
October 26, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27663562/expanding-care-through-a-layered-learning-practice-model
#8
Jill S Bates, Larry W Buie, Lindsey B Amerine, Scott W Savage, Stephen F Eckel, Rachana Patel, John M Valgus, Kamakshi Rao, Rowell Daniels
PURPOSE: The outcomes of a patient-centered layered learning practice model (LLPM) in which the clinical specialist acted as the attending pharmacist and managed a pharmacy team to provide direct patient care were evaluated. METHODS: Two 30-day evaluations were conducted on the acute care malignant hematology and medical oncology services of the University of North Carolina Medical Center in 2011. The primary objective of this study was to design an LLPM that used a team to expand the pharmacist care services offered...
September 23, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27646407/transition-to-enfit-enteral-devices-special-challenges-for-pediatric-institutions
#9
Sarah Bledsoe, Alexandra Oschman, Kyle Hampson, Wendy Hoebing, Damon Pabst
No abstract text is available yet for this article.
September 19, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27646406/improving-health-of-at-risk-rural-patients-project-a-collaborative-care-model
#10
Gary R Matzke, Michael J Czar, William T Lee, Leticia R Moczygemba, L David Harlow
PURPOSE: The design elements of the Improving Health of At-Risk Rural Patients (IHARP) care model are described. SUMMARY: The IHARP project evaluated the clinical, economic, and humanistic outcomes associated with the collaborative care model relative to usual care in the community. The care model was initiated in 22 level 3- certified patient-centered medical homes. The primary outcomes are the absolute change in all relevant clinical and laboratory values of patients with hypertension, hyperlipidemia, and diabetes within and between the intervention and comparator groups; the change in the absolute number of emergency department visits and hospitalizations; and the change in the cost of care among the Medicare and Medicaid intervention patients...
September 19, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864239/development-and-implementation-of-a-pharmacist-run-comprehensive-medication-review-program-in-wisconsin
#11
Danielle L Schoenrock, Katherine Hartkopf, Carrie Boeckelman
PURPOSE: The development and implementation of a centralized, pharmacist-run population health program were pursued within a health system to increase patient exposure to comprehensive medication reviews (CMRs) and improve visit processes. SUMMARY: Program implementation included choosing appropriate pilot pharmacy locations, developing a feasible staffing model, standardizing the workflow, and creating a patient referral process. The impact on patient exposure, specific interventions, and the sustainability of the program were evaluated over a seven-month period...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864238/outcomes-of-a-pharmacist-managed-glucose-collaborative-practice-agreement
#12
Vidya Pugazhenthi, Travis B Dick, Matthew Call
PURPOSE: The impact of a pharmacist-managed glucose collaborative practice agreement (CPA) on glycemic control at a tertiary medical center was investigated. METHODS: A retrospective data analysis was performed on hospitalized, noncritically ill patients admitted between December 2012 and June 2014 who received at least one dose of subcutaneous insulin and experienced at least one blood glucose concentration of 140 mg/dL or higher. The study population was divided into cohorts based on admittance before versus after implementation of the CPA, as well as glucose management by pharmacist versus nonpharmacist provider...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864237/effect-of-selected-clinical-trial-publication-on-adjunctive-nonstatin-medication-prescribing-in-the-veterans-health-administration-system
#13
Krystal S Titus-Rains, Matthew A Cantrell, Jason A Egge, Bruce Alexander, Robert F Shaw, Tami R Argo
PURPOSE: The question of whether publication of selected clinical trials is temporally followed by changes in prescribing of adjunctive lipid-lowering medications was evaluated. METHODS: In this retrospective preanalysis and postanalysis, Veterans Health Administration (VHA) patients 18 years or older who received a new or renewed order for any lipid-lowering medication between April 2, 2004, and September 2, 2014, were included. This period was chosen based on the publication dates of three trials investigating the efficacy of nonstatin medications: Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia (ENHANCE, April 3, 2008), Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus (ACCORD Lipid, March 14, 2010), and Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy (AIM-HIGH, December 15, 2011)...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864236/evaluation-of-adherence-to-current-guidelines-for-treatment-of-hyperlipidemia-in-adults-in-an-outpatient-setting
#14
Christina Ng, Philip Chung, Yuliana Toderika, Angela Cheng-Lai
PURPOSE: Adherence to the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline at an outpatient clinic was evaluated. METHODS: This retrospective chart review study was conducted from December 1, 2013, through November 30, 2014, at an urban outpatient clinic. Estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk was calculated based on the pooled cohort equation for all patients. Patients were categorized into one of four statin-benefit groups, in descending order of ASCVD risk...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864210/summaries-of-safety-labeling-changes-approved-by-fda-boxed-warnings-highlights-july-september-2016
#15
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864209/pharmacists-should-jump-onto-the-clinical-pharmacogenetics-train
#16
Julie A Johnson
No abstract text is available yet for this article.
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864208/payer-view-of-personalized-medicine
#17
Edmund J Pezalla
PURPOSE: The process and methods used by payers when evaluating coverage of personalized medicine testing are described. SUMMARY: Personalized medicine encompasses a number of diagnostic tools that measure drug metabolism, genetic risk for disease development, and tumor type or markers that can guide oncology treatments. However, whole genome testing, tumor marker testing, and testing for drug metabolism are additional costs to the healthcare system. In order to justify these costs, payers and health technology assessment bodies must evaluate the individual tests or groups of tests on their own merits...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864207/clinical-and-regulatory-considerations-in-pharmacogenetic-testing
#18
Robert N Schuck, Elizabeth Marek, Hobart Rogers, Michael Pacanowski
PURPOSE: Both regulatory science and clinical practice rely on best available scientific data to guide decision-making. However, changes in clinical practice may be driven by numerous other factors such as cost. In this review, we reexamine noteworthy examples where pharmacogenetic testing information was added to drug labeling to explore how the available evidence, potential public health impact, and predictive utility of each pharmacogenetic biomarker impacts clinical uptake. SUMMARY: Advances in the field of pharmacogenetics have led to new discoveries about the genetic basis for variability in drug response...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864206/educational-strategies-to-enable-expansion-of-pharmacogenomics-based-care
#19
Kristin Wiisanen Weitzel, Christina L Aquilante, Samuel Johnson, David F Kisor, Philip E Empey
PURPOSE: The current state of pharmacogenomics education for pharmacy students and practitioners is discussed, and resources and strategies to address persistent challenges in this area are reviewed. SUMMARY: Consensus-based pharmacist competencies and guidelines have been published to guide pharmacogenomics knowledge attainment and application in clinical practice. Pharmacogenomics education is integrated into various pharmacy school courses and, increasingly, into Pharm...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27864205/evidence-and-resources-to-implement-pharmacogenetic-knowledge-for-precision-medicine
#20
Kelly E Caudle, Roseann S Gammal, Michelle Whirl-Carrillo, James M Hoffman, Mary V Relling, Teri E Klein
PURPOSE: The current state of pharmacogenetic data curation and dissemination is described, and evidence-based resources for applying pharmacogenetic data in clinical practice are reviewed. SUMMARY: Implementation of pharmacogenetics in clinical practice has been relatively slow despite substantial scientific progress in understanding linkages between genetic variation and variability of drug response and effect. One factor that has inhibited the adoption of genetic data to guide medication use is a lack of knowledge of how to translate genetic test results into clinical action based on currently available evidence...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
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