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American Journal of Health-system Pharmacy: AJHP

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https://www.readbyqxmd.com/read/29367424/pharmacokinetics-safety-and-patient-acceptability-of-subcutaneous-versus-intramuscular-testosterone-injection-for-gender-affirming-therapy-a-pilot-study
#1
David M Wilson, Tony K L Kiang, Mary H H Ensom
PURPOSE: Results of a study comparing testosterone exposure and tolerability with subcutaneous versus i.m. administration are presented. METHODS: In a prospective, open-label, crossover study, adult participants already on stable i.m. testosterone gender-affirming therapy self-injected testosterone cypionate or enanthate i.m. for 3 weeks followed by subcutaneous injections for 8 weeks. Trough serum testosterone concentrations were determined weekly, and serial total serum testosterone (TST) concentrations were determined on postinjection days 1, 3, and 5 of weeks 3 and 11...
January 24, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29348123/rash-associated-with-rivaroxaban-use
#2
Kelly M Rudd, Narmadha Panneerselvam, Anush Patel
PURPOSE: A case of a patient who developed a hypersensitivity reaction to rivaroxaban in the form of a diffuse, exanthematous rash is reported. SUMMARY: After starting rivaroxaban for treatment of cancer-associated deep vein thrombosis (DVT) with pulmonary embolism (PE), a 69-year-old Caucasian woman arrived at an oncology clinic with a diffuse, exanthematous (morbilliform) rash on her neck and torso, spreading to her upper and lower extremities. She reported that the symptoms started to develop about 48 hours after transitioning from subcutaneous enoxaparin to oral rivaroxaban...
January 18, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29343478/treatment-of-gastrointestinal-bleeding-with-idarucizumab-in-a-patient-receiving-dabigatran
#3
Jennifer Mourafetis, Norman Doctor, Simon Leung
PURPOSE: A case report describing use of idarucizumab for dabigatran reversal without the use of hemostatic agents in a patient who developed acute upper gastrointestinal (GI) bleeding while receiving triple antithrombotic therapy is presented. SUMMARY: A 77-year-old man with a complex cardiac history presented to the emergency room with chief complaints of black tarry stools and low blood pressures for 4 days. His past medical history included recent percutaneous coronary intervention (PCI) and drug-eluting stent (DES) placement, atrial fibrillation, hypertension, hyperlipidemia, coronary artery disease, coronary artery bypass graft surgery, stage 3 chronic kidney disease, and cholecystectomy...
January 17, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29339374/multicenter-evaluation-of-a-new-closed-system-drug-transfer-device-in-reducing-surface-contamination-by-antineoplastic-hazardous-drugs
#4
Sylvia B Bartel, Timothy G Tyler, Luci A Power
PURPOSE: Results of a study to evaluate the effectiveness of a recently introduced closed system drug-transfer device (CSTD) in reducing surface contamination during compounding and simulated administration of antineoplastic hazardous drugs (AHDs) are reported. METHODS: Wipe samples were collected from 6 predetermined surfaces in compounding and infusion areas of 13 U.S. cancer centers to establish preexisting levels of surface contamination by 2 marker AHDs (cyclophosphamide and fluorouracil)...
January 16, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29317399/effect-of-a-single-dose-of-i-v-ondansetron-on-qtc-interval-in-emergency-department-patients
#5
Kai Li, Kathy Vo, Byron K Lee, Newton Addo, Zlatan Coralic
PURPOSE: Results of a study to determine whether i.v. administration of a single dose of 4 mg of ondansetron was associated with QT interval prolongation in emergency department (ED) patients are reported. METHODS: In a prospective observational study conducted at an urban academic medical center ED, a convenience sample of adult ED patients treated with ondansetron 4 mg i.v. were enrolled. A 12-lead electrocardiogram (ECG) was obtained immediately before and 5 minutes after ondansetron administration...
January 9, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29255059/pharmacologic-and-clinical-assessment-of-kratom
#6
REVIEW
C Michael White
PURPOSE: This article reviews the pharmacology, clinical utility, adverse effects, and abuse potential of kratom. SUMMARY: The leaves of M. speciosa contain the biologically active alkaloids of kratom. Kratom exerts opioid and α-2 receptor agonistic effects as well as antiinflammatory and parasympathetic-impeding effects. There are no published human pharmacologic, pharmacokinetic, or drug interaction studies on kratom or mitragynine, making it virtually impossible to fully understand kratom's therapeutic potential and risks and the populations most likely to benefit or experience harm from its use...
December 18, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29237587/drone-delivery-of-medications-review-of-the-landscape-and-legal-considerations
#7
Connie A Lin, Karishma Shah, Cherie Mauntel, Sachin A Shah
No abstract text is available yet for this article.
December 13, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436470/improving-medication-related-clinical-decision-support
#8
Clare L Tolley, Sarah P Slight, Andrew K Husband, Neil Watson, David W Bates
PURPOSE: Current uses of medication-related clinical decision support (CDS) and recommendations for improving these systems are reviewed. SUMMARY: Using a systematic approach, articles published from 2007 through 2014 were identified in MEDLINE and EMBASE using MeSH terms and keywords relating to the 5 basic medication-related CDS functionalities. A total of 156 full-text articles and 28 conference abstracts were reviewed across each of the 5 areas: drug-drug interaction (DDI) checks ( n = 78), drug allergy checks ( n = 20), drug dose support ( n = 55), drug duplication checks ( n = 11), and drug formulary support ( n = 20)...
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436469/understanding-inpatient-antimicrobial-stewardship-metrics
#9
Nicholas Bennett, Lucas Schulz, Sarah Boyd, Jason G Newland
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436468/shared-responsibility-for-the-education-of-pharmacy-students
#10
Christopher Turner
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436467/effect-of-provider-selected-order-indications-on-appropriateness-of-antimicrobial-orders-in-a-pediatric-hospital
#11
Yosuke Nomura, Madeleine Garcia, Jason Child, Amanda L Hurst, Daniel Hyman, Amy Poppy, Claire Palmer, Daksha Ranade, Laura Pyle, Sarah K Parker
PURPOSE: The effect of mandatory provider-selected order indications (PSOIs) on appropriateness of antimicrobial ordering in a tertiary pediatric hospital was evaluated. METHODS: Mandatory PSOIs for 14 antimicrobials were implemented in September 2013. Data on initial and final orders in the first 24 hours after ordering were collected from the electronic medical record. Orders from pre-PSOI and post-PSOI implementation were randomly selected and compared with documentation at the time of order to elicit the documentation-determined clinical indication (DDCI)...
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436466/evaluation-of-prescriber-responses-to-pharmacogenomics-clinical-decision-support-for-thiopurine-s-methyltransferase-testing
#12
Samuel Ubanyionwu, Christine M Formea, Benjamin Anderson, Kelly Wix, Ross Dierkhising, Pedro J Caraballo
PURPOSE: Results of a study of prescribers' responses to a pharmacogenomics-based clinical decision support (CDS) alert designed to prompt thiopurine S -methyltransferase (TPMT) status testing are reported. METHODS: A single-center, retrospective, chart review-based study was conducted to evaluate prescriber compliance with a pretest CDS alert that warned of potential thiopurine drug toxicity resulting from deficient TPMT activity due to TPMT gene polymorphism. The CDS alert was triggered when prescribers ordered thiopurine drugs for patients whose records did not indicate TPMT status or when historical thiopurine use was documented in the electronic health record...
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436465/impact-of-a-pharmacy-team-led-intervention-program-on-the-readmission-rate-of-elderly-patients-with-heart-failure
#13
Pamela M Moye, Pui Shan Chu, Teresa Pounds, Maria Miller Thurston
PURPOSE: The results of a study to determine whether pharmacy team-led postdischarge intervention can reduce the rate of 30-day hospital readmissions in older patients with heart failure (HF) are reported. METHODS: A retrospective chart review was performed to identify patients 60 years of age or older who were admitted to an academic medical center with a primary diagnosis of HF during the period March 2013-June 2014 and received standard postdischarge follow-up care provided by physicians, nurses, and case managers...
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436464/treatment-of-pulmonary-hypertension-with-inhaled-agents-in-the-pediatric-intensive-care-unit
#14
LETTER
Holly Catherine Gillis, Gwenyth Fischer, Sameer Gupta
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436463/dealing-with-the-unexpected-during-and-after-hurricane-irma
#15
LETTER
Diane Nitzki-George, Lauren Palowitz, Kristy Sowerby, Kourtney Fusselman, Amanda Borro
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436462/integration-of-physical-assessment-into-pharmacy-practice
#16
LETTER
Erin M Turingan, Jill S Bates, Lindsey B Amerine
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436461/medicare-poised-to-cover-diabetes-prevention-services
#17
Kate Traynor
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29436460/cms-expands-medicare-s-chronic-care-management-services
#18
Cheryl A Thompson
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29326140/navigating-the-residency-application-process-for-lesbian-gay-bisexual-and-transgender-student-pharmacists
#19
Calvin C Daniels, Tate N Trujillo, Christopher M Scott, Lindsey R Kelley
No abstract text is available yet for this article.
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29371198/ashp-association-of-black-health-system-pharmacists-joint-leadership-award
#20
Neil J MacKinnon
No abstract text is available yet for this article.
February 1, 2018: American Journal of Health-system Pharmacy: AJHP
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