Tyler Chanas, Gabrielle Gibson, Elizabeth Langenstroer, David J Herrmann, Thomas W Carver, Kaitlin Alexander, Sai Ho Jason Chui, Lisa Rein, Michael Ha, Kaylee M Maynard, Kristen Bamberg, Mary O'Keefe, Marisa O'Brien, Mariela Cardona Gonzalez, Brandon Hobbs, Mehrnaz Pajoumand, William J Peppard
STUDY OBJECTIVE: Enoxaparin is standard of care for venous thromboembolism (VTE) prophylaxis in adult trauma patients, but fixed-dose protocols are suboptimal. Dosing based on body mass index (BMI) or total body weight (TBW) improves target prophylactic anti-Xa level attainment and reduces VTE rates. A novel strategy using estimated blood volume (EBV) may be more effective based on results of a single-center study. This study compared BMI-, TBW-, EBV-based, and hybrid enoxaparin dosing strategies at achieving target prophylactic anti-Factor Xa (anti-Xa) levels in trauma patients...
March 2024: Pharmacotherapy