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Annals of Pharmacotherapy

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https://www.readbyqxmd.com/read/27920336/reasons-for-discontinuation-and-adverse-effects-of-tnf%C3%AE-inhibitors-in-a-cohort-of-patients-with-rheumatoid-arthritis-and-ankylosing-spondylitis
#1
María Henar García-Lagunar, María Rocío Gutiérrez-Cívicos, María Sergia García-Simón, Pablo Conesa-Zamora, Enrique Jimenez-Santos, Pedro Cano-Vivar, Andrés García-Márquez, Iris Muñoz-García, Alice Charlotte Viney
BACKGROUND: The introduction of anti-tumor necrosis factor α (anti-TNFα) drugs has improved the clinical outcomes in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, these drugs may cause adverse effects that motivate a change in or discontinuation of the treatment. OBJECTIVE: To evaluate the causes of discontinuation or changes in the dosage regimen in a cohort of patients with RA and AS treated with infliximab, adalimumab, etanercept, and golimumab under clinical practice conditions...
December 5, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27903771/reply-association-between-proton-pump-inhibitors-and-microscopic-colitis-implications-for-practice-and-future-research
#2
LETTER
Ernest H Law, Melissa Badowski, Todd A Lee
No abstract text is available yet for this article.
November 29, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27903770/comment-association-between-proton-pump-inhibitors-and-microscopic-colitis-implications-for-practice-and-future-research
#3
LETTER
Bas P M Verhaegh, Marieke J Pierik, Daisy M A E Jonkers
No abstract text is available yet for this article.
November 29, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27895236/a-review-of-single-tablet-regimens-for-the-treatment-of-hiv-1-infection
#4
REVIEW
Jamielynn C Sebaaly, Denise Kelley
OBJECTIVE: To review the pharmacokinetics, safety, drug-drug interactions, and advantages and disadvantages of currently available single-tablet regimens (STRs) for HIV-1 infection. DATA SOURCES: A search using PubMed was conducted (up to September 2016) using the following keywords: single tablet regimen AND HIV Additionally, a PubMed search was conducted for each individual STR using the generic names of the agents. Articles were evaluated for content, and additional references were identified from a review of literature citations...
November 27, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27895235/benzodiazepine-initiation-and-dose-escalation-a-risk-factor-for-inpatient-falls
#5
Brian W Skinner, Elizabeth V Johnston, Lindsay M Saum
BACKGROUND: Benzodiazepines (BZDs) place patients at a significant risk of falling. The current literature does not address if this risk is increased during initiation or dose escalations of BZDs. OBJECTIVE: To determine if initiation or dose escalations of BZD regimens are associated with an increased risk of falls in hospitalized patients compared with patients maintained on their home dose or who had their dose decreased from baseline. METHODS: This retrospective case-control study evaluated hospitalized patients aged 45 years or older who received a BZD...
November 27, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27889699/comparison-of-clinical-factors-between-patients-with-angiotensin-converting-enzyme-inhibitor-induced-angioedema-and-cough
#6
Pär Hallberg, Julia Nagy, Malgorzata Karawajczyk, Leif Nordang, Gunilla Islander, Pia Norling, Hans-Erik Johansson, Mary Kämpe, Svante Hugosson, Qun-Ying Yue, Mia Wadelius
BACKGROUND: Angioedema is a rare and serious adverse drug reaction (ADR) to angiotensin-converting enzyme (ACE) inhibitor treatment. Dry cough is a common side effect of ACE inhibitors and has been identified as a possible risk factor for angioedema. OBJECTIVE: We compared characteristics between patients with ACE inhibitor-induced angioedema and cough with the aim of identifying risk factors that differ between these adverse events. METHODS: Data on patients with angioedema or cough induced by ACE inhibitors were collected from the Swedish database of spontaneously reported ADRs or from collaborating clinicians...
November 25, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27886982/impact-of-norepinephrine-weight-based-dosing-compared-with-non-weight-based-dosing-in-achieving-time-to-goal-mean-arterial-pressure-in-obese-patients-with-septic-shock
#7
Nina Vadiei, Mitchell J Daley, Manasa S Murthy, Carrie S Shuman
BACKGROUND: Currently, a lack of standardization exists in norepinephrine dosing units, the first-line vasopressor for septic shock. Timely achievement of goal mean arterial pressure (MAP) is dependent on optimal vasopressor dosing. OBJECTIVE: To determine if weight-based dosing (WBD) of norepinephrine leads to earlier time to goal MAP compared with non-WBD in obese patients with septic shock. METHODS: This was a retrospective, multicenter cohort study...
November 24, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27881693/outcomes-of-rivaroxaban-use-in-patients-with-sickle-cell-disease
#8
LETTER
Shubha Bhat, Jin Han
No abstract text is available yet for this article.
November 22, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27881692/monitoring-of-urate-lowering-therapy-among-us-veterans-following-the-2012-american-college-of-rheumatology-guidelines-for-management-of-gout
#9
Jonathan C Hughes, Jessica L Wallace, Candace L Bryant, Brent E Salvig, T Neal Fourakre, William J Stone
BACKGROUND: With the prevalence of and hospitalizations for gout increasing, optimizing care for patients with gout is imperative. The 2012 American College of Rheumatology gout guidelines emphasize that timely monitoring is key to achieving serum urate (SUA) goals. Few studies have examined this metric following the 2012 update, and to our knowledge, none have examined a veteran population. OBJECTIVE: To evaluate adherence to urate-lowering therapy (ULT) monitoring guidelines in a veteran population...
November 22, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27866147/benefits-potential-harms-and-optimal-use-of-nutritional-supplementation-for-preventing-progression-of-age-related-macular-degeneration
#10
REVIEW
Carlos H Rojas-Fernandez, Kevin Tyber
OBJECTIVE: To briefly review age-related macular degeneration (AMD), the main findings from the Age Related Eye Disease Study (AREDS) report number 8 on the use of nutritional supplements for AMD, and to focus on data suggesting that supplement use should be guided using genetic testing of AMD risk genes. DATA SOURCES: A literature search (January 2001 through October 26, 2016) was conducted using MEDLINE and the following MeSH terms: Antioxidants/therapeutic use, Genotype, Macular Degeneration/drug therapy, Macular degeneration/genetics, Dietary Supplements, Proteins/genetics, and Zinc Compounds/therapeutic use Bibliographies of publications identified were also reviewed...
November 19, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27864338/ertapenem-and-valproic-acid-drug-interaction-in-an-adult-status-epilepticus-patient
#11
LETTER
Hilary M Teibel, Jody C Rocker, Klepper A Garcia
No abstract text is available yet for this article.
November 18, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27838680/randomized-controlled-trial-to-determine-the-efficacy-of-early-switch-from-vancomycin-to-vancomycin-alternatives-as-a-strategy-to-prevent-nephrotoxicity-in-patients-with-multiple-risk-factors-for-adverse-renal-outcomes-stop-nt
#12
Joseph J Carreno, Rachel M Kenney, George Divine, Jose A Vazquez, Susan L Davis
BACKGROUND: Use of alternative antimicrobials to vancomycin is a potential strategy to reduce acute kidney injury (AKI) in high-risk patients, but current data do not support widespread adoption of this practice. OBJECTIVE: To determine the efficacy of early switch to a nonnephrotoxic alternative for prevention of AKI in high-risk patients who receive vancomycin. METHODS: This was an IRB-approved, prospective randomized controlled trial in a single, tertiary care academic medical center...
November 11, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27834194/risk-of-bleeding-in-patients-on-full-dose-enoxaparin-with-venous-thromboembolism-and-selective-serotonin-reuptake-inhibitors
#13
Nephy G Samuel, Charles F Seifert
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are very commonly prescribed agents that are also potent antiplatelet agents. OBJECTIVE: This study was designed compare the rate of major bleeding events between patients who were treated with low-molecular-weight heparin (LMWH) for venous thromboembolism (VTE) on SSRIs and those not on chronic SSRI therapy. METHODS: This was a retrospective cohort study of 575 patients with a primary or secondary diagnosis of an acute VTE initiated on full-dose enoxaparin with or without an SSRI between October 1, 2009, and October 1, 2014, in a 443-bed, single tertiary care referral county teaching hospital...
November 9, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27794128/association-of-acetaminophen-and-ibuprofen-use-with-wheezing-in-children-with-acute-febrile-illness
#14
Ilan Matok, Arnon Elizur, Amichai Perlman, Shani Ganor, Hagai Levine, Eran Kozer
BACKGROUND: Many infants and children receive acetaminophen and/or ibuprofen during febrile illness. Previously, some studies have linked acetaminophen and ibuprofen use to wheezing and exacerbation of asthma symptoms in infants and children. OBJECTIVE: To assess whether acetaminophen or ibuprofen use are associated with wheezing in children presenting to the emergency department (ED) with febrile illness. METHODS: This was a cross-sectional study of children who presented with fever to the pediatric ED between 2009 and 2013...
October 27, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27798319/treatment-patterns-in-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#15
Maithili Deshpande, Jennifer Arnoldi
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a complex disease entity with limited guidance surrounding medication therapy. OBJECTIVE: To evaluate a patient population with possible ACOS and their medication regimen based on the Global Initiative for Asthma and Global Initiative for COPD joint statement for ACOS. METHODS: This was a retrospective study based at a large clinical practice within a school of medicine...
October 25, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27798318/comparing-usual-care-with-a-warfarin-initiation-protocol-after-mechanical-heart-valve-replacement
#16
Gregory Roberts, Rasha Razooqi, Stephen Quinn
BACKGROUND: The immediate postoperative warfarin sensitivity for patients receiving heart valve prostheses is increased. Established warfarin initiation protocols may lack clinical applicability, resulting in dosing based on clinical judgment. OBJECTIVE: To compare current practice for warfarin initiation with a known warfarin initiation protocol, with doses proportionally reduced to account for the increased postoperative sensitivity. METHODS: We compared the Mechanical Heart Valve Warfarin Initiation Protocol (Protocol group) with current practice (clinical judgment-Empirical group) for patients receiving mechanical heart valves in an observational before-and-after format...
October 25, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27798317/a-clinical-pharmacist-patient-safety-initiative-to-reduce-against-label-prescribing-of-statins-with-cyclosporine
#17
Donald G Lamprecht, Brittany A Todd, Anne M Denham, Leslie K Ruppe, Sheila L Stadler
BACKGROUND: Against-label prescribing of statins with interacting drugs, such as cyclosporine, represents an important patient safety concern. OBJECTIVE: To implement and evaluate the effectiveness of a clinical pharmacist patient-safety initiative to minimize against-label prescribing of statins with cyclosporine. METHODS: Kaiser Permanente Colorado clinical pharmacists identified patients receiving both cyclosporine and against-label statin through prescription claims data...
October 25, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27760857/reply-assessing-the-economic-impact-of-liposomal-bupivacaine-in-total-knee-arthroplasty
#18
Jennifer Ann Phillips, Amish Doshi
No abstract text is available yet for this article.
October 18, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27742761/comment-intravenous-acetaminophen-for-postoperative-pain-management-in-patients-undergoing-living-laparoscopic-living-donor-nephrectomy
#19
Xiulu Ruan, Jin Jun Luo, Adam Marc Kaye, Alan David Kaye
No abstract text is available yet for this article.
October 14, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27733668/evaluation-of-a-symptom-triggered-benzodiazepine-protocol-utilizing-sas-and-ciwa-ar-scoring-for-the-treatment-of-alcohol-withdrawal-syndrome-in-the-critically-ill
#20
Soumitra Sen, Philip Grgurich, Amanda Tulolo, Andrew Smith-Freedman, Yuxiu Lei, Anthony Gray, James Dargin
BACKGROUND: There are limited data on the efficacy of symptom-triggered therapy for alcohol withdrawal syndrome (AWS) in the intensive care unit (ICU). OBJECTIVE: To evaluate the safety and efficacy of a symptom-triggered benzodiazepine protocol utilizing Riker Sedation Agitation Scale (SAS) scoring for the treatment of AWS in the ICU. METHODS: We performed a before-and-after study in a medical ICU. A protocol incorporating SAS scoring and symptom-triggered benzodiazepine dosing was implemented in place of a protocol that utilized the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale and fixed benzodiazepine dosing...
October 12, 2016: Annals of Pharmacotherapy
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