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Annals of Pharmacotherapy

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https://www.readbyqxmd.com/read/29463107/outcomes-of-a-pharmacist-managed-heart-failure-medication-titration-assistance-clinic
#1
Shubha Bhat, Mayank Kansal, George T Kondos, Vicki Groo
BACKGROUND: National guidelines recommend angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) and β-blockers (BBs) at target doses for morbidity and mortality benefits in heart failure with reduced ejection fraction (HFrEF); regardless, titration of these therapies in practice remains suboptimal. We implemented an outpatient pharmacist-managed HFrEF medication titration assistance clinic (MTAC) at one institution to improve titration for general cardiology (GC) patients...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457494/management-of-phenobarbital-and-apixaban-interaction-in-recurrent-cardioembolic-stroke
#2
Philip K King, Trevor A Stump, Allyn M Walkama, Benjamin M Ash, Susana M Bowling
No abstract text is available yet for this article.
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457493/the-impact-of-vitamin-d-supplementation-on-attention-deficit-hyperactivity-disorder-in-children
#3
Hatem Hamed Elshorbagy, Naglaa Fathy Barseem, Waleed Elsayed Abdelghani, Hany Abdelaziz Ibrahim Suliman, Ashraf Hamed Al-Shokary, Sameh Elsayed Abdulsamea, Akram Elshafey Elsadek, Yehia Hamed Abdel Maksoud, Dalia Mohamed Abd El-Hassib Nour El Din
BACKGROUND: The role of nutrients and dietary factors in attention-deficit hyperactivity disorder (ADHD) remains unclear. OBJECTIVES: The primary objective was to evaluate the serum vitamin D level in children with a diagnosis of ADHD. The secondary objective was to detect the effect of vitamin D supplementation on cognitive function in those with vitamin D deficiency. METHODS: A total of 50 children with ADHD and 40 healthy controls were included in the study...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457492/the-risk-of-community-acquired-enteric-infection-in-proton-pump-inhibitor-therapy-systematic-review-and-meta-analysis
#4
Radwan A Hafiz, Chia Wong, Stuart Paynter, Michael David, Geeske Peeters
BACKGROUND: Previous meta-analyses suggest that users of proton pump inhibitors (PPIs) have a higher risk of developing enteric infections compared with nonusers. These previous meta-analyses have considerable heterogeneity, and it is not clear whether the effect of PPIs is different for different types of microorganisms. OBJECTIVE: The aim of this study is to update previous meta-analyses, concentrating on enteric infection in community settings and exploring potential sources of heterogeneity...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457491/critical-care-pharmacists-and-medication-management-in-an-icu-recovery-center
#5
Joanna L Stollings, Sarah L Bloom, Li Wang, E Wesley Ely, James C Jackson, Carla M Sevin
BACKGROUND: Many patients experience complications following critical illness; these are now widely referred to as post-intensive care syndrome (PICS). An interprofessional intensive care unit (ICU) recovery center (ICU-RC), also known as a PICS clinic, is one potential approach to promoting patient and family recovery following critical illness. OBJECTIVES: To describe the role of an ICU-RC critical care pharmacist in identifying and treating medication-related problems among ICU survivors...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457490/demonstration-of-resistant-or-wild-type-virus-in-recurrent-viremia-after-ganciclovir-resistant-cytomegaloviral-infection
#6
Margaret R Jorgenson, Jillian L Descourouez, Robert R Redfield, Jeannina A Smith, Didier A Mandelbrot
BACKGROUND: Ganciclovir-resistant cytomegalovirus (GR-CMV) is a serious complication of transplantation. Recurrence after primary infection is common. Little is known about CMV drug resistance and latency. OBJECTIVE: Review CMV genotype during episodes of recurrent CMV viremia after prior documentation of ganciclovir resistance to evaluate if resistance is redemonstrated. METHODS: All adult transplant recipients with history of GR-CMV viremia from January 1, 2011, to December 31, 2015, were screened; those with subsequent laboratory evidence of recurrent CMV viremia and genotyping were included...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29457489/shingrix-the-new-adjuvanted-recombinant-herpes-zoster-vaccine
#7
Stephanie F James, Elias B Chahine, Allana J Sucher, Cassandra Hanna
OBJECTIVES: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles. DATA SOURCES: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. STUDY SELECTION/DATA EXTRACTION: The literature search was limited to human studies published in English...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29442544/pyridoxine-add-on-treatment-for-the-control-of-behavioral-adverse-effects-induced-by-levetiracetam-in-children-a-case-control-prospective-study
#8
Marino Silvia, Vitaliti Giovanna, Marino Simona Domenica, Pavone Piero, Provvidenti Simona, Romano Catia, Falsaperla Raffaele
BACKGROUND: Few studies on adult and pediatric patients have shown pyridoxine efficacy as additional therapy for those receiving levetiracetam (LEV) to prevent and mitigate behavioral adverse effects (BAEs). OBJECTIVE: The aim of our study was to analyze the safety and efficacy of pyridoxine supplementation in the prevention of LEV adverse effects, including suicidal ideation. METHODS: This randomized, case-control trial included patients receiving LEV as monotherapy treatment...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29442543/dolutegravir-dual-therapy-as-maintenance-treatment-in-hiv-infected-patients-a-review
#9
Rosaleen Boswell, Michelle M Foisy, Christine A Hughes
OBJECTIVE: To review available evidence for dolutegravir-based dual therapy as maintenance treatment in HIV-1 infected patients. DATA SOURCES: A literature search was conducted using PubMed, MEDLINE, and Google Scholar to the end of January 2018. Conference abstracts and article bibliographies were also reviewed. STUDY SELECTION AND DATA EXTRACTION: All English-language, randomized, and observational studies were included. DATA SYNTHESIS: In all, 12 studies were identified: 10 were observational, and 2 were randomized trials...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29442542/comparison-of-the-nephrotoxicity-of-vancomycin-in-combination-with-cefepime-meropenem-or-piperacillin-tazobactam-a-prospective-multicenter-study
#10
Brandon P Mullins, C Joseph Kramer, Billie J Bartel, Jennifer S Catlin, Richard E Gilder
BACKGROUND: Patients often receive broad-spectrum antibiotics for nosocomial infections commonly with activity against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Previous retrospective and/or single-center studies have suggested that the combination of vancomycin and piperacillin/tazobactam might be associated with an increased risk of acute kidney injury. OBJECTIVES: To compare the incidence of nephrotoxicity in patients receiving intravenous vancomycin in combination with cefepime, meropenem, or piperacillin/tazobactam...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29430947/successful-implementation-of-a-simple-algorithm-to-manage-penicillin-allergy-in-an-acute-care-community-hospital
#11
Kwang Yoon, Michelle Lee, Ramesh Patel, Zoon Park
No abstract text is available yet for this article.
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29424239/assessment-of-cardiovascular-risk-with-glucagon-like-peptide-1-receptor-agonists-in-patients-with-type-2-diabetes-using-an-alternative-measure-to-the-hazard-ratio
#12
Masayuki Kaneko, Mamoru Narukawa
BACKGROUND: Randomized clinical trials with the aim of evaluating the cardiovascular risks associated with glucagon-like peptide 1 (GLP-1) receptor agonists, lixisenatide, liraglutide, semaglutide, and exenatide, have been conducted. They showed different results among the agents, but the reason has not been explained. OBJECTIVE: To evaluate the cardiovascular risks associated with GLP-1 receptor agonists by using an alternative measure to the hazard ratio. METHODS: We used the difference in restricted mean survival time (RMST) as a measure of cardiovascular risks...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29424238/the-rise-and-fall-of-metronidazole-for-clostridium-difficile-infection
#13
Elias B Chahine
Clostridium difficile is posing urgent health threats. Older studies have shown that metronidazole and vancomycin are equally effective in the treatment of Clostridium difficile infection (CDI). Given its inexpensive cost and low propensity to select antimicrobial resistant organisms, metronidazole became rapidly the drug of choice despite its pharmacokinetic limitations in the treatment of CDI. However, newer studies demonstrated that metronidazole is inferior to vancomycin, prompting clinicians to change their long-standing position on using metronidazole for mild to moderate infections and on reserving vancomycin for severe infections...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29400082/administration-rates-of-the-tdap-vaccine-in-obstetric-patients
#14
Jamie Koerner, Alicia B Forinash, Abigail M Yancey, Jessica Brinkmeyer, Spencer Dingman, Collin Miller, Judy Thompson, Laura Bergin, Julia D López, Amy Ravin
BACKGROUND: Infants younger than 6 months of age are at high risk for contracting pertussis because of not being fully vaccinated. The Advisory Committee on Immunization Practices (ACIP) recommends vaccinating all pregnant women with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) between 27 and 36 weeks to offer passive immunity to the infant to help protect them until they are able to receive the full pertussis series. OBJECTIVE: To assess and compare compliance with the 2013 ACIP recommendation of vaccinating pregnant women with Tdap at 27 to 36 weeks' gestation in 2 obstetric clinics...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29400081/association-of-statin-therapy-with-risk-of-epilepsy-in-2-propensity-score-matched-cohorts
#15
Lakshya U Trivedi, Carlos A Alvarez, Ishak A Mansi
BACKGROUND: Studies have suggested that statins may have a neuroprotective effect against epilepsy. However, evidence from rat models and case reports have suggested an opposite effect. Overall data are limited. OBJECTIVE: To examine the association between statin use and epilepsy risk in a general population and in a healthy population (individuals with no severe comorbidities). METHODS: Patients were Tricare beneficiaries from October 2003 to March 2012...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29363356/sedative-plasma-concentrations-and-delirium-risk-in-critical-illness
#16
Joanna L Stollings, Jennifer L Thompson, Benjamin A Ferrell, Mika Scheinin, Grant R Wilkinson, Christopher G Hughes, Ayumi K Shintani, E Wesley Ely, Timothy D Girard, Pratik P Pandharipande, Mayur B Patel
BACKGROUND: The relationship between plasma concentration of sedatives and delirium is unknown. OBJECTIVE: We hypothesized that higher plasma concentrations of lorazepam are associated with increased delirium risk, whereas higher plasma concentrations of dexmedetomidine are associated with reduced delirium risk. METHODS: This prospective cohort study was embedded in a double-blind randomized clinical trial, where ventilated patients received infusions of lorazepam and dexmedetomidine...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29363355/biologic-induced-infections-in-inflammatory-bowel-disease-the-tnf-%C3%AE-antagonists
#17
Sean M McConachie, Sheila M Wilhelm, Ashish Bhargava, Pramodini B Kale-Pradhan
OBJECTIVE: To review the mechanism and association of infectious risk among the tumor-necrosis factor α (TNF-α) antagonists used in inflammatory bowel disease. DATA SOURCES: A PubMed literature search was performed using the following search terms: infliximab, adalimumab, certolizumab, golimumab, inflammatory bowel disease, crohn's, ulcerative colitis, adverse effects, adverse events, safety, and infection. STUDY SELECTION AND DATA EXTRACTION: Meta-analyses and cohort studies with outcomes pertaining to quantitative infectious risk were reviewed...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29363354/a-review-of-the-clinical-toxicology-of-yew-poisoning
#18
Alexander W Labossiere, Dennis F Thompson
OBJECTIVES: Yew plant materials contain highly toxic taxine alkaloids. Serious ingestions can result in life-threatening toxicity. The purpose of this article is to summarize the literature on the treatment of acute yew poisoning. DATA SOURCES: PubMed (January 1946 to November 2017) was searched using the search terms "taxus/po". EMBASE (1980 to November 2017) was searched using the search terms "taxus/to" and "yew.mp." Web of Science (1945 to November 2017) was searched using the text words taxus, taxine, and yew...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29363353/varenicline-induced-panic-disorder-in-a-previously-healthy-patient
#19
Shawn Nomani, Karl Torbicki, Tamara Mihic
No abstract text is available yet for this article.
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29359574/efficacy-and-safety-of-subcutaneous-neostigmine-for-ileus-acute-colonic-pseudo-obstruction-or-refractory-constipation
#20
Bridgette Kram, Maegan Greenland, Mollie Grant, Michael E Campbell, Charlotte Wells, Courtney Sommer
BACKGROUND: Neostigmine is traditionally administered intravenously for treatment of acute colonic pseudo-obstruction (ACPO), though use is associated with administration constraints and adverse effects. OBJECTIVE: To evaluate whether an alternative route of administration for neostigmine via subcutaneous (SQ) delivery is safe and effective in a broad cohort of medical and surgical patients. METHODS: This multicenter, retrospective observational study included adult patients administered SQ neostigmine for ileus, ACPO, or refractory constipation...
January 1, 2018: Annals of Pharmacotherapy
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