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Annals of Pharmacotherapy

Emily L Singleton, Nancy Le, Genevieve Lynn Ness
The latest aminophylline shortage has prompted a need for alternative reversal agents for pharmacological stress testing. Cardiac stress testing is common for diagnosis and prognosis in patients with coronary heart disease. Options for pharmacological stress test agents include adenosine, regadenoson, dipyridamole, and dobutamine, whereas aminophylline is the recommended reversal agent. Adenosine and dobutamine can be used as alternatives to regadenoson and dipyridamole to decrease or eliminate the use of aminophylline...
October 11, 2018: Annals of Pharmacotherapy
Alyssa D Rabon, Shawn H MacVane
No abstract text is available yet for this article.
October 11, 2018: Annals of Pharmacotherapy
Nihel Khoudour, Annelise Martin, Marie Allard, Manuela Tiako Meyo, Benoit Blanchet
No abstract text is available yet for this article.
October 11, 2018: Annals of Pharmacotherapy
Marie Smith
The implementation and expansion of primary care (PC) pharmacist medication optimization and management services has been hindered mainly by the lack of a payment mechanism for PC providers to engage pharmacist services. If pharmacists expect to be included in new PC team-based payment models, we need to actively engage in ongoing PC practice transformation discussions with PC organizational leaders. In this commentary, examples of integrated PC pharmacist services and payment models are provided to (1) reinforce the feasibility of pharmacist integration into expanded PC teams and (2) share with PC leaders, payers, and policy makers...
October 10, 2018: Annals of Pharmacotherapy
Uma Fogueri, Wisit Cheungapasitporn, David Bourne, Fernando C Fervenza, Melanie S Joy
BACKGROUND: Rituximab (RTX) is a chimeric monoclonal anti-CD20 antibody used off-label in the treatment of membranous nephropathy (MN). Unfortunately, limited information is available on the pharmacokinetics of therapeutic proteins such as RTX in patients with glomerular kidney diseases. OBJECTIVE: The current study evaluated RTX pharmacokinetics in patients with MN (n = 20) who received 4 RTX weekly intravenous infusions (375 mg/m2 ) over a month, with a repeat of the identical treatment at 6 months...
October 8, 2018: Annals of Pharmacotherapy
Ashlee Baucom, Christina Brizendine, Ann Fugit, Christopher Dennis
BACKGROUND: In February 2016, a pharmacy-to-dose (PTD) pneumococcal vaccination protocol was implemented to aid in the appropriate selection of pneumococcal vaccines. OBJECTIVE: The primary objective was to compare the rate of appropriate vaccine ordering with the PTD protocol. Secondary objectives were to assess vaccine administration rate and determine factors preventing patients from receiving the vaccine after appropriate selection. METHODS: This was a single-center, retrospective cohort study of adult patients admitted to an inpatient service...
October 4, 2018: Annals of Pharmacotherapy
Doyle M Cummings, Alyssa Adams, Jacquie Halladay, Alan Hinderliter, Katrina E Donahue, Crystal W Cene, Quefeng Li, Cassandra Miller, Beverly Garcia, Jim Tillman, Edwin Little, Darren DeWalt
BACKGROUND: Racial disparities in blood pressure (BP) control persist, but whether differences by race in antihypertensive medication intensification (AMI) contribute is unknown. OBJECTIVE: To compare AMI by race for patients with elevated home BP readings. METHODS: This prospective cohort study followed adult patients from 6 rural primary care practices who used home BP monitoring (HBPM) and recorded/reported values. For providers, AMI was encouraged when mean HBPM systolic blood pressure (SBP) values were ⩾135 mm Hg; patients received phone-based coaching on HBPM technique and sharing HBPM findings...
October 3, 2018: Annals of Pharmacotherapy
Ching-Wen Chu, Chih-Sung Liang
No abstract text is available yet for this article.
October 3, 2018: Annals of Pharmacotherapy
Xian Jie Cindy Chen, Karen Fong, Diana Altshuler, Yanina Dubrovskaya, Eddie Louie, Nancy Amoroso, Ronald Goldenberg, John Papadopoulos
BACKGROUND: Parameters within reconstitution, storage, stability, and administration may be optimized according to the unique pharmacokinetics of each antibiotic to ensure a successful desensitization. OBJECTIVE: The study aims to evaluate the successfulness and safety of antibiotic desensitization protocols developed by the pharmacy department at our institution. METHODS: A retrospective study was conducted at an 800-bed, urban, tertiary care, academic medical center...
September 20, 2018: Annals of Pharmacotherapy
Tim Tran, Simone E Taylor, Andrew Hardidge, Elise Mitri, Parnaz Aminian, Johnson George, Rohan A Elliott
BACKGROUND: Medication errors commonly occur when patients move from the community into hospital. Whereas medication reconciliation by pharmacists can detect errors, delays in undertaking this can increase the risk that patients receive incorrect admission medication regimens. Orthopedic patients are an at-risk group because they are often elderly and use multiple medications. OBJECTIVE: To evaluate the prevalence and nature of medication errors when patients are admitted to an orthopedic unit where pharmacists routinely undertake postprescribing medication reconciliation...
September 20, 2018: Annals of Pharmacotherapy
Caroline S Quinn, Margaret R Jorgenson, Jillian L Descourouez, Brenda L Muth, Brad C Astor, Didier A Mandelbrot
BACKGROUND: Biologic agents inhibiting the tumor necrosis factor α pathway (TNFα-Is) are used to treat systemic inflammatory diseases. The best management of these agents after renal transplantation is unknown. OBJECTIVE: Evaluate peritransplant use of TNFα-Is and associated outcomes. METHODS: Retrospective, single-center study of adult renal-transplant-recipients (RTRs) transplanted between 1/1/1998-12/31/2017, who received TNFα-Is for inflammatory disease prior to transplant...
September 20, 2018: Annals of Pharmacotherapy
Meredith L Howard, Roya Hossaini, Catherine Tolar, Marian L Gaviola
BACKGROUND: Hospitalized patients are subject to acute illness and stress which may impact appetite or weight. Loss of appetite may lead to increased morbidity or mortality. Medications such as dronabinol, megestrol, and mirtazapine are used for weight gain in the outpatient setting; however, there is limited information about safety or effectiveness when initiated inpatient. OBJECTIVES: To analyze the effectiveness and safety of appetite-stimulating medications in hospitalized patients...
September 19, 2018: Annals of Pharmacotherapy
Ling Yin, Dennis Dubovetsky, Patricia Louzon-Lynch
BACKGROUND: Intradialytic hypotension (IDH) is the most commonly reported complication of hemodialysis (HD) treatment. At our institution, dialysis patients often have both 25% albumin and normal saline ordered as rescue options for management of IDH, without specification of which agent to use first. OBJECTIVE: The purpose of this study was to determine the effect of an algorithm for IDH management. METHODS: A retrospective study was conducted in HD patients who experienced IDH...
September 15, 2018: Annals of Pharmacotherapy
Rhiannon M Bath, Brandelyn E Doering, Michael D Nailor, Kellie J Goodlet
OBJECTIVE: To describe and quantify the incidence and morbidity of hepatitis B reactivation (HBVr) secondary to pharmaceutical agents (eg, rituximab, tumor necrosis factor inhibitors, direct-acting antivirals [DAAs] for hepatitis C) among patients with previously resolved hepatitis B infection. DATA SOURCES: The MEDLINE database was searched from inception through July 2018 using the terms hepatitis B + ( reactivation OR [drug or drug class linked to HBVr]). STUDY SELECTION AND DATA EXTRACTION: Relevant English-language cohort studies or randomized trials quantifying the incidence of HBVr secondary to pharmacotherapy among patients negative for hepatitis B surface antigen and DNA and positive for hepatitis B core antibody were included...
September 11, 2018: Annals of Pharmacotherapy
Sydney K Shelton, Sandra R Bai, Joseph K Jordan, Amy Heck Sheehan
OBJECTIVE: To review the efficacy, safety, and place in therapy of ixekizumab for the treatment of moderate to severe plaque psoriasis. DATA SOURCES: PubMed (1966 to July 2018) and were searched using the terms ixekizumab, LY2439821, interleukin-17, and psoriasis. STUDY SELECTION AND DATA EXTRACTION: Human studies published in peer-reviewed medical journals in English were used. DATA SYNTHESIS: The efficacy and safety of ixekizumab has been primarily reported by 4 phase III trials (UNCOVER-1, UNCOVER-2, UNCOVER-3, and UNCOVER-J) and multiple post hoc analyses...
September 6, 2018: Annals of Pharmacotherapy
Leticia Xyn Yen Peh, Shyamala Narayanaswamy, Aiwen Wang
No abstract text is available yet for this article.
September 6, 2018: Annals of Pharmacotherapy
Matthew A Wanat, Kalliopi Fitousis
No abstract text is available yet for this article.
September 6, 2018: Annals of Pharmacotherapy
Sarah E Petite, Julie A Murphy
BACKGROUND: Effective inpatient chronic obstructive pulmonary disease (COPD) exacerbation management is critical to appropriately manage health care resources. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines provide recommendations on appropriate systemic corticosteroid and antibiotic use, in select patients, for COPD exacerbation. OBJECTIVE: To determine the impact of GOLD guideline-recommended systemic corticosteroid and antibiotic therapy in the hospital setting on clinical outcomes in patients with COPD exacerbation...
September 3, 2018: Annals of Pharmacotherapy
Joshua Caballero, Raymond L Ownby, Robin J Jacobs, Jennifer E Thomas, Mark S Schweizer
BACKGROUND: One of the fastest growing populations living with HIV is older adults especially those 65 years of age or older. Current antiretroviral therapy (ART) has prolonged life expectancy of persons with HIV. However, for therapy to be effective, patients need to be adherent. Over time, older persons with HIV may experience HIV-associated neurocognitive disorders or other factors that could affect ART adherence. The use of expedient cognitive tests that help measure medication adherence may be useful for the optimal care of these patients...
September 3, 2018: Annals of Pharmacotherapy
Roy A Pleasants
OBJECTIVE: To review the pharmacology, efficacy, and safety of the first nebulized long-acting muscarinic antagonist (LAMA), glycopyrrolate (GLY)/eFlow closed system (CS) nebulizer, approved for maintenance treatment of chronic obstructive pulmonary disease (COPD). DATA SOURCES: A PubMed search was conducted (January 2000 to July 2018) using the following terms/phrases: nebulized glycopyrrolate, inhalation devices in COPD, long-acting muscarinic antagonists COPD, and COPD survey...
September 1, 2018: Annals of Pharmacotherapy
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