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International Journal of Pediatric Otorhinolaryngology

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https://www.readbyqxmd.com/read/30342776/erratum-to-skewed-x-chromosome-inactivation-and-next-generation-sequencing-to-identify-a-novel-smpx-variants-associated-with-x-linked-hearing-loss-in-a-chinese-family-int-j-pediatr-otorhinolaryngol-2018-88-93
#1
Song Gao, Yi Jiang, Guojian Wang, Yongyi Yuan, Shasha Huang, Xue Gao, Xiaohong Li, Dejun Zhang, Jian Wu, Xiaowen Ji, Tao Deng, Ligang Wang, Dongyang Kang, Pu Dai
No abstract text is available yet for this article.
October 18, 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368403/identification-of-pathogenic-genes-and-upstream-regulators-in-allergic-rhinitis
#2
Yanhua Lei, Ping Guo, Jun An, Chao Guo, Fengxiang Lu, Minglei Liu
BACKGROUND: Allergic rhinitis (AR) is the main cause of irreversible blindness in older individuals. Our study aims to identify the key genes and upstream regulators in AR. METHODS: To screen pathogenic genes of AR, an integrated analysis was performed by using the microarray datasets in AR derived from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were further discovered by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368402/a-comparative-study-between-adenoids-and-nasal-mucosa-for-ciliated-epithelium-in-children-with-recurrent-or-chronic-rhinosinusitis
#3
Christine M Kim, Earl H Harley
OBJECTIVE: To determine whether adenoid epithelium is superior to nasal mucosa for biopsy of ciliated epithelium for electron microscopy (EM) to evaluate pediatric patients with rhinosinusitis for primary ciliary dyskinesia (PCD). METHODS: A retrospective review compared electron microscopic results in children with chronic or recurrent rhinosinusitis who underwent both adenoidectomy or nasopharyngeal biopsy and nasal mucosa biopsy in the course of evaluation for PCD at a tertiary care institution...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368401/an-analysis-of-the-literature-addressing-tonsillectomy-knowledge-gaps
#4
Craig M Cooper, Jake X Checketts, Lacy Brame, Harrison Gray, Jaye Bea Downs, Matt Vassar
IMPORTANCE: The ability of clinical practice guidelines to improve patient outcomes depends on the quality of evidence that they are built upon. Research into tonsillectomy in children is lacking, and the gaps in evidence were identified by guideline authors. OBJECTIVE: The objective of this study is to evaluate the extent that new research is addressing the gaps identified in the AAO-HNS Tonsillectomy in Children Guideline. DESIGN: For each recommendation in the AAO-HNS guideline Tonsillectomy In Children, we created PICO (Participants, Intervention, Comparator, Outcome) questions and search strings...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368400/predictive-ability-of-bedside-nasal-endoscopy-to-diagnose-invasive-fungal-sinusitis-in-a-pediatric-population
#5
Carolyn L Mulvey, Mark D Rizzi, Adva Buzi
INTRODUCTION: Invasive fungal sinusitis (IFS) is a rare but deadly clinical entity that occurs in immunocompromised patients. Diagnosis in children typically requires operative biopsies under general anesthesia, which has associated risks. Findings on bedside nasal endoscopy (BNE) can be used with history, exam, and imaging to determine the need for surgery, however, the accuracy of this tool has not been established among pediatric patients. METHODS: Patients who underwent BNE for evaluation of IFS from 2008 to 2016 at the Children's Hospital of Philadelphia were identified using Current Procedural Terminology (CPT) codes...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368399/association-between-symptomatic-submucous-cleft-palate-and-otologic-disease-a-retrospective-review
#6
Adam Kwinter, Ann Dworschak-Stokan, Josee Paradis, Murad Husein
INTRODUCTION: Submucous cleft palate (SMCP) is the most common congenital malformation of the posterior palate and characterized in part by palatal muscle diastasis. Patients with SMCP are considered symptomatic when suffering from velopharyngeal insufficiency which leads to hypernasality of speech and excess nasal air emission. SMCP results from defects in the muscles thought to be responsible for regulating the patency of the eustachian tube which can lead to a number of middle ear pathologies and ultimately hearing loss...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368398/does-intratympanic-xylitol-administration-have-ototoxic-effects-in-a-mouse-ear-model
#7
Eda Tuna Yalcinozan, Ebru Kösemihal, Mehmet Ates Aksit, Remzi Tinazli, Hasan Safakogullari, Kadir Cagdas Kazikdas, Mustafa Asim Safak
OBJECTIVE: To research the ototoxicity of xylitol after intratympanic injection in mice ear model. METHODS: 24 female mice Balb/c mice (48 ears) included in the study. The mice were divided into 4 groups as 6 mice were found (12 ears) in each group. Solutions of 0.9% NaCl solution (Group A), 155 mg/ml (Group B), 310 mg/ml (Group C) and 620 mg/ml (Group D) xylitol, were applied into the middle ear cavity. Microscopic ear examination and auditory brainstem response test were done for each mouse before application of xylitol and on the 1st, 3rd and 10th day of injection...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368397/cephalic-de-mucosalized-superiorly-based-pharyngeal-flap-a-modified-mucosa-preserving-technique-for-velopharyngeal-insufficiency
#8
Sherif M Askar, Mohammad Waheed El-Anwar, Ahmed S Elaassar, Amal S Quriba, Ahmed Anany, Ashraf Elmalt, Ahmed I Elsayed, Mohammed S Abd El-Azeem
INTRODUCTION: Superiorly-based pharyngeal flap (PF) is the most frequently employed surgical technique to correct velopharyngeal insufficiency (VPI). Bared posterior pharyngeal wall might prolong the period of convalescence with throat pain and discomfort. Delayed donor site healing problems and subsequent fibrosis with downward migration of the transposed flap might be one a cause of failure and might necessitate revision. AIM OF THE WORK: To present a modified technique of PF aiming at dealing with the problems of donor site defects via immediate self-mucosal covering of the cephalic portion of the bed...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368396/skull-base-anatomy-and-surgical-safety-in-isolated-and-charge-associated-bilateral-choanal-atresia
#9
Nicholas S Fitzpatrick, Anthony C Bartley, Elhamy Bekhit, Robert G Berkowitz
INTRODUCTION: Bilateral choanal atresia (BCA) is associated with a high incidence of congenital abnormalities that include skull base anomalies and defects. Surgical repair of BCA is necessary in the early neonatal period and any altered anatomy of the adjacent skull base will heighten the risk of intracranial injury. This risk may be further increased in patients with CHARGE syndrome. OBJECTIVES: To measure surgically relevant nasal and skull base dimensions in neonates with BCA in order to determine whether any difference exists between isolated and CHARGE syndrome associated subgroups, thereby optimizing the safety of surgical repair...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368395/adenoid-hypertrophy-affects-screening-for-primary-ciliary-dyskinesia-using-nasal-nitric-oxide
#10
Tomas Rybnikar, Marian Senkerik, Jaroslav Chladek, Jirina Chladkova, David Kalfert, Lukas Skoloudik
AIM: In patients with primary ciliary dyskinesia (PCD), the release of nitric oxide (NO) is extremely low by epithelia of the nasopharynx and sinuses. Measurement of nasal NO (nNO) is recommended as a screening test for PCD. The study aimed to evaluate if adenoids affects nNO and may deteriorate the performance of the test. METHODS: In 48 nonallergic patients between 5 and 18 years of age with chronic symptoms of nasal obstruction and indications for adenoidectomy, the measurements of nNO by chemiluminescence analyser and nasal patency by active anterior rhinomanometry were performed both before and after adenoidectomy...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368394/employing-bioabsorbable-grafts-in-two-stage-laryngotracheal-reconstruction-of-pediatric-patient-with-severe-subglottic-stenosis-and-history-of-airway-surgery
#11
Elliot Le, Lenhanh Tran
A 16-month old female was referred to our practice for laryngotracheal reconstruction (LTR) for acquired subglottic stenosis (SGS) diagnosed at 4 weeks of age due to prolonged intubation. She has a history of open thoracic repair of congenital tracheoesophageal fistula that was complicated by a pneumothorax and phrenic nerve paralysis. We performed a variation of an anterior and posterior cricoid split LTR with tracheal stenting in order to avoid risks of pulmonary morbidity from costochondral cartilage harvesting...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368393/dacryoendoscopy-assisted-nasal-endoscopic-marsupialization-for-congenital-dacryocystocele
#12
Tushar Sarbajna, Yasuhiro Takahashi, Ma Regina Paula Valencia, Marian Grace Ana-Magadia, Eri Ishikawa, Hirohiko Kakizaki
OBJECTIVE: To examine the surgical outcome of dacryoendoscopy-assisted nasal endoscopic marsupialization for congenital dacryocystocele. METHODS: This is a retrospective, observational study that included 7 sides of 6 patients with congenital dacryocystocele. The surgical indication in 5 of the patients was acute dacryocystitis while one of the patients had no spontaneous resolution after long-term observation. Dacryoendoscopy was used for visualisation of the lacrimal cavity, direct probing of the obstruction at the common canaliculus, and localisation of a deflated intranasal cyst after an initial incision of the cyst...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368392/management-and-outcomes-of-pediatric-vocal-cord-paresis-in-chiari-malformation
#13
Minyoung Jang, Phillip Biggs, Lauren North, Andrew Foy, Robert Chun
INTRODUCTION: Pediatric vocal cord paresis (VCP) has a variety of etiologies, including congenital neurologic disease. Arnold-Chiari Malformation (ACM) is one such disease with known VCP association. However, the natural history, need for tracheostomy, and rate of decannulation in this patient population is not well characterized. OBJECTIVE: To provide prognostic information on infants with ACM and VCP. METHODS: A retrospective chart review was conducted of patients with both ACM and VCP at a single institution...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368391/sphenoidal-sinogenic-extradural-empyema-associated-with-juvenile-myelomonocytic-leukemia
#14
N Guignard, T Roujeau, L Saumet, G Gascou, M Mondain, M Akkari
Intracranial empyema is a rare but serious complication of sinusitis in children. Myelodysplastic/myeloproliferative syndromes (MMS), including juvenile myelomonocytic leukemia (JMML), can lead to immunosuppression, thus favouring infections. We report the case of a sphenoid sinogenic retro-clival extradural empyema in a 14-year-old female patient associated with JMML. Treatment consisted in an endonasal transphenoidal drainage of the empyema associated with intravenous antibiotherapy. The patient was thereafter enrolled in chemotherapeutic treatment with Azacitidine...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368390/evaluating-diagnostic-yield-of-computed-tomography-ct-and-magnetic-resonance-imaging-mri-in-pediatric-unilateral-sensorineural-hearing-loss
#15
Janki Shah, Gina Nhu Pham, Jessica Zhang, Keerthana Pakanati, Nikhila Raol, Julina Ongkasuwan, Brandon Hopkins, Samantha Anne
INTRODUCTION: Options for imaging for evaluation of pediatric patients with unilateral sensorineural hearing loss (USNHL) include computed tomography (CT) and magnetic resonance imaging (MRI). Although both CT and MR imaging provide valuable information in the evaluation of pediatric patients with USNHL, debate remains regarding which imaging modality is most ideal and should be the preferred study for these children. The objective of this study is to evaluate and compare the diagnostic yield of CT versus MRI in children with USNHL...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368389/cleft-lip-and-palate-associated-hearing-loss-in-brazilian-children
#16
Ricardo Neves Godinho, Tania Sih, Cássio da Cunha Ibiapina, Márcia Helena Miranda de Freitas Oliveira, Ana Luiza de Freitas Rezende, Renata Victória Tassara
INTRODUCTION: Cleft lip and palate children have chronic otitis media related to Eustachian Tube dysfunction and associated conductive hearing loss. In this group of children, communicative skill development limitations, in association with orofacial aesthetics and functional disorders, can lead to behavioral, educational and social problems. METHODS: We evaluated the minimum hearing threshold and the air-bone gap (ABG) in a range from 500 to 4000 Hz for 4-14 years old cleft lip and palate children (CLPC)...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368388/novel-presentation-of-cranial-fasciitis-of-the-mandible-case-report-and-literature-review
#17
REVIEW
Katie de Champlain, Kyle C Kurek, Warren K Yunker
Cranial fasciitis (CF) is a rare benign fibroblastic lesion of the scalp, most commonly affecting the pediatric population. The authors conducted a literature review and include a summary of reported cases of CF. CF is most commonly located in the parietal and temporal regions of the skull. The majority of cases are found in males and in children under a few years of ago. We describe the clinical, pathological and radiological findings of the first reported case of CF of the mandible. In this case, the patient was a 12 month-old male who presented with a one-month history of a rapidly enlarging mass along his left mandibular ramus...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368387/a-novel-gel-patch-for-minimally-invasive-repair-of-tympanic-membrane-perforations
#18
Benjamin J Rubinstein, Jesse D Ranney, Parastoo Khoshakhlagh, Barry Strasnick, Elaine L Horn-Ranney
OBJECTIVE: Evaluate the efficacy of a photocrosslinkable gel patch for repairing tympanic membrane (TM) perforations using a minimally invasive procedure. METHODS: 38 adult male chinchillas underwent bilateral TM perforation via CO2 laser (n = 76 TMs). Eight weeks post-perforation induction, either a gel patch (n = 26) or EpiDisc (n = 12) was applied to the perforation through the ear canal. Perforation margins were not abraded prior to gel patch application in order to make the procedure minimally invasive...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368386/anterior-skull-base-duplication-requiring-delivery-via-exit-procedure-a-case-report
#19
Courtney B Shires, Jonathan P Giurintano, Jennifer McLevy-Bazzanella, Jerome Thompson
Duplication of the anterior skull base structures is an extremely rare malformation of failed midline blastogenesis. We present the case of a child with an obstructive oral cavity mass diagnosed on prenatal imaging. The child was successfully delivered by EXIT procedure, a tracheotomy was performed, and postnatal imaging demonstrated an array of craniofacial malformations, including complete duplication of the maxilla, pituitary glands, aqueducts of Sylvius, and basilar arteries. The child underwent excision of the duplicate maxilla, resulting in a wide cleft palate that will be repaired at a future date...
December 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/30368385/targeted-next-generation-sequencing-reveals-otof-mutations-in-auditory-neuropathy-spectrum-disorder
#20
Kaitian Chen, Min Liu, Xuan Wu, Ling Zong, Hongyan Jiang
OBJECTIVE: To study the genetic etiology of auditory neuropathy spectrum disorder (ANSD) in a Chinese family and perform a literature review of OTOF mutations and cochlear implantation (CI). METHODS: Sequential targeted next generation sequencing (NGS) and CI was performed for the proband. Further, 50 DNA samples from unrelated families with nonsyndromic deafness were examined for frequency determination. The impact of OTOF mutations on hearing recovery after CI was assessed through the literature survey...
December 2018: International Journal of Pediatric Otorhinolaryngology
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