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Journal of Clinical Periodontology

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https://www.readbyqxmd.com/read/28646601/autophagy-activation-is-required-for-myofibroblasts-differentiation-during-healing-of-oral-mucosa
#1
Enrica Vescarelli, Andrea Pilloni, Francesco Dominici, Paola Pontecorvi, Antonio Angeloni, Antonella Polimeni, Simona Ceccarelli, Cinzia Marchese
AIM: It is known that periodontal tissues heal faster that skin, and gingiva in particular heal without scar formation. The mechanisms regulating this behavior are still unclear. The aim of our work is to compare wound healing in oral mucosa and gingiva, investigating the role of αSMA-expressing myofibroblasts and autophagy. MATERIALS AND METHODS: Biopsies were obtained from 7 patients immediately before and 24h after vertical releasing incision in oral mucosa and attached gingiva...
June 24, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28644556/sinus-augmentation-using-a-mini-pig-model-effect-of-ceramic-and-allogeneic-bone-biomaterials
#2
Cristiano Susin, Tiago Fiorini, Jaebum Lee, Rubens Moreno de Freitas, Hsien-Chung Chiu, Hari S Prasad, Amanda N Buxton, Ulf Me Wikesjö
BACKGROUND: Present clinical practice broadly relies on off-the-shelf allogeneic, xenogeneic or synthetic bone biomaterials in support of sinus augmentation. Also, recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge carrier (rhBMP-2/ACS) has been shown to support clinically relevant bone formation when used to augment the maxillary sinus. OBJECTIVES: To evaluate local bone formation/dental implant osseointegration following implantation of two particulate bone biomaterials using the mini-pig sinus augmentation model...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28644512/association-of-flossing-interdental-cleaning-and-periodontitis-in-adults
#3
M Soledad Cepeda, Rachel Weinstein, Clair Blacketer, Michael Lynch
AIM: Assess the association of flossing with periodontitis. MATERIALS AND METHODS: This was a cross-sectional study using the National Health and Nutrition Examination Survey (NHANES) years 2011-2014. We used three categories of flossing: 0-1, 2-4, and ≥5 days in the past week and the CDC definition of periodontitis. We calculated odds ratios controlling for age, gender, smoking, drinking, income, and dentist visits. RESULTS: A total of 6939 adult subjects were included, 35% flossed ≤1 time a week and 40% had periodontitis...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28643883/is-ridge-preservation-augmentation-at-periodontally-compromised-extraction-sockets-safe-a-retrospective-study
#4
Jung-Ju Kim, Heithem Ben Amara, Frank Schwarz, Hae-Young Kim, Jung-Won Lee, Ulf Me Wikesjö, Ki-Tae Koo
OBJECTIVES: This study aimed to evaluate the safety of ridge preservation/augmentation procedures when performed at compromised extraction sockets. METHODS: Patients subject to ridge preservation/augmentation at periodontally compromised sockets at Seoul National University Dental Hospital(SNUDH) were evaluated in a chart review. Tooth extractions due to acute infection were not included in our study as chronically formed lesions are the only lesions that can be detected from radiographic images...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28621003/effect-of-periodontal-therapy-with-systemic-antimicrobials-on-parameters-of-metabolic-syndrome
#5
Sergio Bizzarro, Ubele van der Velden, Wijnand J Teeuw, Victor E A Gerdes, Bruno G Loos
AIM: To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL-cholesterol, triglycerides, glucose). METHODS: 110 periodontitis patients without known comorbidities and unaware of possible MetS, were randomly assigned to BPT (n=56) or BPT+AM (n=54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS, was also determined...
June 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28586532/periodontal-status-and-serum-biomarker-levels-in-hfe-hemochromatosis-patients-a-case-series-study
#6
Vincent Meuric, Fabrice Lainé, Emile Boyer, Sandrine Le Gall-David, Emmanuel Oger, Denis Bourgeois, Philippe Bouchard, Edouard Bardou-Jacquet, Valérie Turmel, Martine Bonnaure-Mallet, Yves Deugnier
AIM: To investigate the association between periodontal status and serum biomarkers in patients with HFE hemochromatosis. MATERIAL AND METHODS: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated...
June 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28570003/age-of-onset-of-disease-in-subjects-with-severe-periodontitis-a-9-to-34-year-retrospective-study
#7
Sara Thorbert-Mros, Björn Cassel, Tord Berglundh
AIM: The aim was to retrospectively assess the age of onset of disease in a group of patients, 30-45 years of age, diagnosed with severe, generalized periodontitis. MATERIAL & METHODS: 74 patients agreed to be part of the study. Patient files and radiographs of 42 patients were retrieved from >80 private and public dental clinics. Interproximal sites in radiographs presenting with identifiable cement-enamel junction (CEJ) and alveolar bone crest (BC) were analyzed...
June 1, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28570002/role-of-poly-adp-ribose-polymerase-activation-in-the-pathogenesis-of-periodontitis-in-diabetes
#8
Kei Adachi, Shin-Ichi Miyajima, Nobuhisa Nakamura, Megumi Miyabe, Yasuko Kobayashi, Toru Nishikawa, Yuki Suzuki, Takeshi Kikuchi, Shuichiro Kobayashi, Tomokazu Saiki, Makoto Mizutani, Norikazu Ohno, Toshihide Noguchi, Akio Mitani, Tatsuaki Matsubara, Keiko Naruse
AIM: The etiology of progressive periodontitis in diabetes has not yet been elucidated. We previously demonstrated that nitrosative stress is increased in diabetic rats with periodontitis. Nitrosative stress induces poly(ADP-ribose) polymerase (PARP) activation. Here, we demonstrated the involvement of PARP activation in diabetic periodontitis and detailed the therapeutic effects of PARP inhibitor. MATERIALS AND METHODS: Experimental periodontitis was induced by placing a nylon thread ligature...
June 1, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28569991/the-role-of-5-lipoxygenase-in-aggregatibacter-actinomycetemcomitans-induced-alveolar-bone-loss
#9
Mila Fernandes Moreira Madeira, Celso Martins Queiroz Junior, Jôice Dias Corrêa, Sílvia Maria Cordeiro Werneck, Fabiana Simão Machado, Thiago Mattar Cunha, Gustavo Pompermaier Garlet, Mauro Martins Teixeira, Tarcília Aparecida da Silva, Daniele G Souza
AIM: Leukotrienes (LTs) are pro-inflammatory lipid mediators formed by the enzyme 5-lipoxygenase (5-LO). The involvement of 5-LO metabolites in periodontal disease (PD) is not well defined. This study aimed to assess the role of 5-LO in experimental PD induced by Aggregatibacter actinomycetemcomitans (Aa). MATERIAL AND METHODS: In vivo experiments were carried out using SV129 wild type (WT) and 5-LO deficient (5lo(-/-) ) mice inoculated with Aa. Osteoclasts were stimulated in vitro with AaLPS in the presence or not of selective inhibitors of the 5-LO pathway, or LTB4 or platelet-activating factor (PAF), since PAF has already been shown to increase osteoclast activity...
June 1, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28556062/clinical-and-microbiological-effects-of-the-adjunctive-use-of-probiotics-in-the-treatment-of-gingivitis-a-randomized-controlled-clinical-trial
#10
Eduardo Montero, Margarita Iniesta, Marta Rodrigo, María José Marín, Elena Figuero, David Herrera, Mariano Sanz
AIM: To evaluate the efficacy of a probiotic combination in the treatment of gingivitis and to assess its impact on the subgingival microbiota. MATERIAL AND METHODS: A placebo-controlled clinical trial was conducted in gingivitis subjects during 6 weeks. Test treatment consisted on the administration of two oral tablets per day containing the probiotic strains Lactobacillus plantarum, Lactobacillus brevis and Pediococcus acidilactici; the control group received the same tablets but without live bacteria...
May 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28555944/association-of-salivary-peroxidase-activity-and-concentration-with-periodontal-health-a-validity-study
#11
M Memarzadeh Zahedani, Ch Schwahn, R Baguhl, Th Kocher, H Below, A Welk
AIM: Whereas the relationship between myeloperoxidase and periodontitis has been widely examined, that between salivary peroxidase and periodontitis has received little attention. We examined how periodontitis depends on both salivary peroxidase activity and concentration. MATERIALS AND METHODS: A full mouth, clinical assessment of probing depth was performed in a sample of 46 participants aged 25-54 years. To minimize bias, these data were corrected by data from the general population (Study of Health in Pomerania)...
May 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28555928/impact-of-excessive-gingival-display-on-oral-health-related-quality-of-life-in-a-southern-brazilian-young-population
#12
Raquel Pippi Antoniazzi, Luana de Sena Fischer, Carlos Eduardo Agostini Balbinot, Simone Pippi Antoniazzi, Jovito Adiel Skupien
AIM: to compare oral health-related quality of life (OHRQoL) between individuals with and without excessive gingival display (EGD). MATERIALS AND METHODS: A cross-sectional study was conducted in 53 individuals with EGD and 53 controls matched for sex and age. The outcome was OHRQoL, determined using the Oral Health Impact Profile (OHIP-14) and self-perceptions of satisfaction with smile esthetics. A clinical exam was conducted to evaluate the smile line, color of the teeth, tooth wear and malocclusion...
May 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28556187/lipopolysaccharide-a-possible-molecular-mediator-between-periodontitis-and-coronary-artery-disease
#13
John M Liljestrand, Susanna Paju, Kåre Buhlin, Rutger G Persson, Seppo Sarna, Markku S Nieminen, Juha Sinisalo, Päivi Mäntylä, Pirkko J Pussinen
AIM: We aimed to study how lipopolysaccharide in saliva and serum associates with each other, periodontal microbial burden, periodontitis and coronary artery disease. MATERIALS AND METHODS: The used Parogene-cohort comprised N=505 Finnish adults. Coronary diagnosis was acquired by coronary angiography and the main outcomes were: no significant coronary artery disease (n = 123), stable coronary artery disease (n = 184) and acute coronary syndrome (n = 169). Periodontitis was defined according to clinical and radiographic examinations...
May 27, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28548243/cross-reactive-saliva-iga-antibodies-to-oxidized-ldl-and-periodontal-pathogens-in-humans
#14
Ramin Akhi, Chunguang Wang, Mikael Kyrklund, Outi Kummu, S Pauliina Turunen, Kati Hyvärinen, Arja Kullaa, Tuula Salo, Pirkko J Pussinen, Sohvi Hörkkö
AIM: Oxidized Low-Density Lipoproteins (oxLDL) are formed as a result of lipid peroxidation and are highly immunogenic and proatherogenic. In this study, saliva antibodies binding to oxLDL, Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa), were characterized and their cross reactivity was evaluated. MATERIAL & METHODS: Resting and stimulated saliva samples were collected from 36 healthy adults (mean age 26 years). Saliva IgA, IgG and IgM autoantibody levels to copper oxidized LDL (CuOx-LDL) and malondialdehyde acetaldehyde modified LDL (MAA-LDL), were determined with chemiluminescence immunoassay...
May 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28548232/hard-and-soft-tissue-integration-of-immediate-and-delayed-implants-with-a-modified-coronal-macro-design-histologic-micro-ct-and-volumetric-soft-tissue-changes-from-a-pre-clinical-in-vivo-study
#15
I Sanz-Martin, F Vignoletti, J Nuñez, M Permuy, F Muñoz, J Sanz-Esporrín, L Fierravanti, L Shapira, M Sanz
AIM: To study the healing of peri-implant tissues around implants with a triangular coronal third (test) or cylindrical (control). MATERIAL AND METHODS: In eight beagle dogs, immediate and delayed implants were placed. Test and control implants were randomly assigned and the hard and soft tissue healing was evaluated with histology and Micro CT analysis at 4 weeks and 12 weeks. The soft tissue contour changes were assessed by image analysis software. RESULTS: When measured at the implant shoulder level, the buccal crestal width (primary outcome assessed in mm) attained similar values in test and control implants...
May 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28548211/a-haplotype-block-downstream-of-plasminogen-is-associated-with-chronic-and-aggressive-periodontitis
#16
Matthias Munz, Hong Chen, Yvonne Jockel-Schneider, Knut Adam, Per Hoffman, Klaus Berger, Thomas Kocher, Jörg Meyle, Peter Eickholz, Christof Doerfer, Matthias Laudes, André Uitterlinden, Wolfgang Lieb, Andre Franke, Stefan Schreiber, Steven Offenbacher, Kimon Divaris, Corinna Bruckmann, Bruno G Loos, Soeren Jepsen, Henrik Dommisch, Arne S Schaefer
AIM: The intronic variant rs4252120 in the plasminogen gene (PLG) is known to be associated with aggressive periodontitis (AgP) and atherosclerosis. Here, we examined the chromosomal region spanning PLG for associations with both chronic periodontitis (CP) and AgP. MATERIAL AND METHODS: The association of PLG candidate rs4252120 was tested in a German case-control sample of 1,419 CP cases using the genotyping assay hCV11225947 and 4,562 controls, genotyped with HumanOmni BeadChips...
May 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28548210/xenogeneic-collagen-matrix-versus-connective-tissue-graft-for-buccal-soft-tissue-augmentation-at-implant-site-a-randomized-controlled-clinical-trial
#17
Francesco Cairo, Luigi Barbato, Paolo Tonelli, Guido Batalocco, Gabriella Pagavino, Michele Nieri
BACKGROUND: Peri-implant soft tissue may be critical to prevent inflammation and promote gingival margin stability. The purpose of this randomized clinical trial (RCT) is to compare Xenogeneic Collagen Matrix (XCM) versus Connective Tissue Graft (CTG) to increase buccal soft tissue thickness at implant site. MATERIAL AND METHODS: Soft tissue augmentation with XCM (test) or CTG (control) was performed at 60 implants in 60 patients at the time of implant uncovering...
May 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28504365/cost-effectiveness-of-non-surgical-periodontal-therapy-for-patients-with-type-2-diabetes-in-the-uk
#18
Josephine Solowiej-Wedderburn, Mark Ide, Mark Pennington
AIM: Periodontal therapy has been shown to reduce glycated haemoglobin in patients with diabetes, although considerable uncertainty remains regarding the sustainability of such changes. We evaluate the cost-effectiveness of non-surgical periodontal therapy and rigorous maintenance treatment in patients with type 2 diabetes and periodontitis from a provider perspective in the UK. METHOD: Lifetime costs relating to periodontal treatment were modelled for a cohort of patients with type 2 diabetes...
May 15, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28498507/effect-of-surgical-periodontal-treatment-associated-to-antimicrobial-photodynamic-therapy-on-chronic-periodontitis-a-randomized-controlled-clinical-trial
#19
Sérgio H L Martins, Arthur B Novaes, Mario Taba, Daniela B Palioto, Michel R Messora, Danilo M Reino, Sérgio L S Souza
AIM: This randomized controlled clinical trial evaluated the effects of an adjunctive single application of antimicrobial photodynamic therapy (aPDT) in Surgical Periodontal Treatment (ST) in patients with severe chronic periodontitis (SCP). MATERIAL AND METHODS: In a split-mouth design, 20 patients with SCP were treated with aPDT+ST (Test Group, TG) or ST only (Control Group, CG). aPDT was applied in a single episode, using a diode laser and a phenothiazine photosensitizer...
May 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28498497/the-aggravation-of-arthritis-by-periodontitis-is-dependent-of-il-17-receptor-a-activation
#20
Sabrina G de Aquino, Jhimmy Talbot, Fabiane Sônego, Walter M Turato, Renata Grespan, Mario J Avila-Campos, Fernando Q Cunha, Joni A Cirelli
AIM: To evaluate whether Porphyromonas gingivalis-induced periodontitis aggravates the antigen-induced arthritis (AIA) model, and whether this effect is dependent on the Th17/IL-17 signalling pathway. MATERIALS AND METHODS: Antigen-induced arthritis was triggered by local injection of methylated bovine serum albumin into the knee joint of previously immunized C57BL/6 wild-type (WT) and IL-17 receptor A (IL-17RA)-knockout mice. Periodontal disease in naïve or arthritic mice was induced by oral infection with P...
May 12, 2017: Journal of Clinical Periodontology
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