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Journal of Clinical Periodontology

Afsar R Naqvi, Maria F Brambila, Gloria Martínez, Gabriela Chapa, Salvador Nares
AIM: To evaluate human and herpesvirus-encoded microRNA (miRNA) expression in healthy and diseased gingiva of obese and non-obese subjects and compare the impact of localized and systemic inflammation on human miRNA profiles. MATERIAL AND METHODS: Healthy and inflamed gingival biopsies were collected from obese and non-obese subjects. Human and herpesvirus miRNA expression was quantified using quantitative PCR. Predicted targets of dysregulated miRNAs were identified using bioinformatics analysis, validated by dual luciferase assays and their expression assessed in healthy and diseased tissues...
November 30, 2018: Journal of Clinical Periodontology
Gustavo G Nascimento, Márcia T Gastal, Fábio R M Leite, Luciana A Quevedo, Karen G Peres, Marco A Peres, Bernardo L Horta, Fernando C Barros, Flávio F Dermarco
AIM: To investigate the association between depression and periodontitis among adults enrolled in the 1982 Pelotas Birth Cohort, Brazil. MATERIALS AND METHODS: Major depressive episode and severity of depressive symptoms obtained in 2012 were considered the exposure of this study. In 2013, periodontitis, the outcome of interest, was clinically assessed and two different case definitions were used: the CDC/AAP and a combination of CAL and BOP simultaneously. Serum levels of C-reactive protein and frequency of dental flossing were defined as mediators while confounders comprised a set of variables collected throughout the life-course of the participants...
November 30, 2018: Journal of Clinical Periodontology
Christoph A Ramseier, Martina Nydegger, Clemens Walter, Gabriel Fischer, Anton Sculean, Niklaus P Lang, Giovanni E Salvi
AIM: To relate the time between recall visits and residual periodontal probing depths (PPD) to periodontal stability in patients enrolled in supportive periodontal therapy (SPT). MATERIALS AND METHODS: Retrospective data on residual PPDs from 11'842 SPT visits were evaluated in SPT patients at the Medi School of Dental Hygiene (MSDH), Bern, Switzerland 1985-2011. A residual PPD-based algorithm was developed to compute SPT-intervals with no expected change of residual PPD...
November 30, 2018: Journal of Clinical Periodontology
Mi Du, Tao Bo, Kostas Kapellas, Marco A Peres
AIMS: To comprehensively review, identify and critically assess the performance of models predicting the incidence and progression of periodontitis. METHODS: Electronic searches of the MEDLINE via PubMed, EMBASE, DOSS, Web of Science, Scopus and ProQuest databases, and hand searching of reference lists and citations were conducted. No date or language restrictions were used. The Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies checklist was followed when extracting data and appraising the selected studies...
November 5, 2018: Journal of Clinical Periodontology
Heithem Ben Amara, Daniel Thoma, Frank Schwarz, Hyun Young Song, Joseph Capetillo, Ki-Tae Koo
OBJECTIVE: To test whether or not topically administered recombinant human epidermal growth factor (rhEGF) accelerates the early healing phase of oral soft tissue wounds. METHODS: One day following the creation of palatal defects (n=6/animal), 14 dogs were allocated to one of the following five groups: spontaneous healing (SH), vehicle ointment (V), vehicle ointment + rhEGF at concentrations of 1μg/g (EGF1), 10μg/g (EGF10) or 50μg/g (EGF50). Topical administration of ointments was repeated twice per day until sacrifice at days 8 and 16...
October 29, 2018: Journal of Clinical Periodontology
Young Woo Song, Tobias Waller, Jae-Kook Cha, Sungtae Kim, Sung-Won Cho, Ui-Won Jung, Daniel S Thoma
OBJECTIVES: To evaluate the histologic and volumetric changes of gingival tissues following grafting with collagen-based matrices at labial aspect of teeth in canines. MATERIAL AND METHODS: Gingival augmentation was performed in the mandibular incisor area using two types of xenogeneic cross-linked collagen matrices (CCMs), bovine CCM for BCCM group and porcine CCM for PCCM group, whereas the contralateral sides remained untreated (B-control group and P-control group)...
October 29, 2018: Journal of Clinical Periodontology
Dan Henry Levy, Iain L C Chapple, Lior Shapira, Avi Golan-Goldhirsh, Jacob Gopas, David Polak
OBJECTIVES: Nupharidine (6,6'-Dihydroxythiobinupharidine), purified from the aquatic plant Nuphar lutea leaves (Water lily) prompts antimicrobial activity of immune cells. The aim of the study was to test the effect of Nupharidine on neutrophil function against Aggregatibacter actinomycetemcomitans, JP2 clone (Aa-JP2). METHODS: Neutrophils derived from the human cell line HL60 and human peripheral blood derived from aggressive periodontitis and periodontally healthy subjects were incubated with Nupharidine or vehicle and inoculated with JP2...
October 29, 2018: Journal of Clinical Periodontology
Yago Leira, Manuel Rodríguez-Yáñez, Susana Arias, Iria López-Dequidt, Francisco Campos, Tomás Sobrino, Francesco D'Aiuto, José Castillo, Juan Blanco
AIM: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI. MATERIAL AND METHODS: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. In addition, a measure of periodontal inflammation and disease activity, namely the periodontal inflamed surface area (PISA), was also calculated for each patient...
October 26, 2018: Journal of Clinical Periodontology
Logan T Cowan, Kamakshi Lakshminarayan, Pamela L Lutsey, Aaron R Folsom, James Beck, Steven Offenbacher, James S Pankow
AIM: Periodontal disease is a cardiovascular disease (CVD) risk factor but few studies have considered the relationship between periodontal disease and venous thromboembolism (VTE). We hypothesized that periodontal disease is independently associated with increased risk of incident VTE. MATERIALS AND METHODS: We used data from 8,092 participants of the Atherosclerosis Risk in Communities (ARIC) study to examine periodontal disease in 1996-1998 and incident VTE through 2011...
October 26, 2018: Journal of Clinical Periodontology
Mayte Martinez-Herrera, Sandra López-Domènech, Francisco Javier Silvestre, Javier Silvestre-Rangil, Celia Bañuls, Antonio Hernández-Mijares, Milagros Rocha
AIM: The effect of dietary weight loss intervention on periodontal therapy is unknown. Therefore, we aimed to evaluate whether weight loss improves the response of obese subjects to non-surgical periodontal treatment. MATERIALS AND METHODS: This interventional study in obese patients was conducted at the University Hospital Dr. Peset (Valencia, Spain). Patients were divided into two groups with and without dietary therapy. All participants received non-surgical periodontal treatment...
October 26, 2018: Journal of Clinical Periodontology
Małgorzata Pietruska, Anna Skurska, Łukasz Podlewski, Robert Milewski, Jan Pietruski
AIM: To compare outcomes of modified coronally advanced tunnel technique (MCAT) combined with either collagen matrix (CM) or subepithelial connective tissue graft (SCTG) in the treatment of Miller class I and II multiple gingival recessions in the mandible. MATERIAL AND METHODS: The study encompassed 91 recessions in 29 patients for whom MCAT was combined with CM on one side of the mandible and SCTG on the contralateral one. The following clinical parameters were measured: gingival recession height (GR) and width (RW), probing depth (PD), clinical attachment level (CAL), width of keratinized tissue (KT), gingival thickness (GT), mean (MRC) and complete root coverage (CRC) and Root Coverage Esthetic Score (RES)...
October 26, 2018: Journal of Clinical Periodontology
Mayte Martinez-Herrera, Sandra López-Domènech, Francisco Javier Silvestre, Javier Silvestre-Rangil, Celia Bañuls, Victor M Victor, Milagros Rocha
AIM: To evaluate the relationship between oxidative stress parameters in polymorphonuclear leucocytes (PMNs) and PMN-endothelial cell interactions in patients with chronic periodontitis (CP) according to different degrees of severity of the disease. MATERIALS AND METHODS: For this cross-sectional study, 182 subjects were divided into four groups according to degree of CP: without CP (n = 37), mild CP (n = 59), moderate CP (n = 51), and severe CP (n = 35)...
October 25, 2018: Journal of Clinical Periodontology
Andrea Ravidà, I-Ching Wang, Shayan Barootchi, Houssam Askar, Lorenzo Tavelli, Jordi Gargallo-Albiol, Hom-Lay Wang
AIM: To compare the clinical outcomes of ≤6 mm extra-short implants (test group) versus ≥10 mm long implants (control group), with and without bone augmentation procedures. MATERIALS AND METHODS: A systemic literature search of randomized clinical trials was performed using the PUBMED (MEDLINE) and EMBASE databases. A quantitative meta-analysis was conducted to compare all the outcome variables. Meta-regression analysis determined the effect of bone augmentation procedures and the influence of other clinical covariates on the results...
October 25, 2018: Journal of Clinical Periodontology
Rino Burkhardt, Christoph Hf Hämmerle, Niklaus P Lang
AIM: we want to evaluate the relationship of self-assessed experience and proficiency, manual dexterity and visual-spatial ability with surgical performance. MATERIAL & METHODS: 26 professionals were included in the study which consisted of 4 four parts: 1) self-assessment by a questionnaire regarding proficiency and experience, 2) evaluation of visual-spatial ability, 3) testing of manual dexterity assessed by validated psychomotor tests and 4) evaluation of surgical performance by Objective Structured Assessment of Technical Skills (OSATS)...
October 25, 2018: Journal of Clinical Periodontology
A Kröger, C Hülsmann, S Fickl, T Spinell, F Hüttig, F Kaufmann, A Heimbach, P Hoffmann, N Enkling, S Renvert, F Schwarz, Ryan T Demmer, P N Papapanou, S Jepsen, M Kebschull
AIM: To cross-sectionally analyze the submucosal microbiome of peri-implantitis (PI) lesions at different severity levels. MATERIALS AND METHODS: Microbial signatures of 45 submucosal plaque samples from untreated peri-implantitis lesions obtained from 30 non-smoking, systemically healthy subjects were assessed by 16s sequencing. Linear mixed models were used to identify taxa with differential abundance by probing depth, after correction for age, gender, and multiple samples per subject...
October 20, 2018: Journal of Clinical Periodontology
Praveen Sharma, Zehra Yonel, Michael Busby, Iain L Chapple, Thomas Dietrich
AIMS: To explore the associations between periodontal status and patient reported outcomes (PROs) in a large cohort of patients based in non-specialist general dental practice. MATERIALS AND METHODS: Analysis was conducted using data from 14,620 patients, in 233 non-specialist dental practices across the UK. As part of routine clinical care, data on periodontal probing depths (PPD), alveolar bone loss (ABL), bleeding on probing (BoP) as well as PROs (oral pain/discomfort, dietary restrictions and dental appearance) were recorded using an online database...
October 20, 2018: Journal of Clinical Periodontology
Daniel S Thoma, Robert Haas, Katarzyna Sporniak-Tutak, Abel Garcia, Thomas D Taylor, Christoph H F Hämmerle
AIM: to compare the implant survival rate between short dental implants and standard length implants placed in combination with bone grafting at 5 years of loading. METHODS: This multicenter study enrolled 101 patients (137 implants) with a posterior maxillary bone height of 5-7mm. Patients randomly received either short implants (6mm) (GS) or long implants (11-15mm) with sinus grafting (GG). Six months later, implants were loaded with single crowns and patients re-examined at one, three and five years of loading...
October 20, 2018: Journal of Clinical Periodontology
Ulvi K Gürsoy, Eija Könönen, Taina Tervahartiala, Mervi Gürsoy, Jari Pitkänen, Paula Torvi, Anna Liisa Suominen, Pirkko Pussinen, Timo Sorsa
AIM: To investigate the molecular forms of salivary matrix metalloproteinase (MMP)-8 in relation to periodontitis. MATERIALS AND METHODS: Molecular forms, degree of activation, and fragmentation of neutrophilic and mesenchymal type MMP-8 isoforms were analyzed from salivary samples of 81 subjects with generalized periodontitis, 63 subjects with localized periodontitis, and 79 subjects without pocket teeth, by using western-immunoblots with computer quantitation...
October 20, 2018: Journal of Clinical Periodontology
Luigi Nibali, Yi-Chun Yeh, Daniela Pometti, Yu-Kang Tu
AIM: The aim of this study was to assess the stability over time of periodontal intrabony defects treated with minimally invasive non-surgical therapy (MINST) and supportive periodontal therapy (SPT). METHODS: Clinical and radiographic analysis was carried out in 21 intrabony defects treated with MINST in 14 consecutive patients included in a prospective study and reassessed after 5 years of SPT. Baseline, 1- and 5-year radiographs were analysed, and bone levels were compared by multilevel linear regression adjusted by latent variable method...
October 11, 2018: Journal of Clinical Periodontology
Falk Schwendicke, Joachim Krois, Thomas Kocher, Thomas Hoffmann, Wolfgang Micheelis, Rainer A Jordan
OBJECTIVE: With more teeth retained for longer in an ageing population, population-wide periodontal treatment needs may increase. We assessed and projected periodontal treatment needs from 1997 to 2030 in Germany. METHODS: Partial-mouth probing-pocket depths (PPD) from repeated waves (1997, 2005, 2014) of the nationally-representative German Oral Health Studies were transformed into full-mouth PPDs via decision-tree-based ensemble-modeling. In line with German healthcare-regulations, teeth with PPD≥4mm were regarded as needing periodontal treatment...
October 9, 2018: Journal of Clinical Periodontology
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