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Journal of Clinical Periodontology

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https://www.readbyqxmd.com/read/28504365/cost-effectiveness-of-non-surgical-periodontal-therapy-for-patients-with-type-2-diabetes-in-the-uk
#1
Josephine Solowiej-Wedderburn, Mark Ide, Mark Pennington
AIM: Periodontal therapy has been shown to reduce glycated haemoglobin in patients with diabetes, although considerable uncertainty remains regarding the sustainability of such changes. We evaluate the cost-effectiveness of non-surgical periodontal therapy and rigorous maintenance treatment in patients with type 2 diabetes and periodontitis from a provider perspective in the UK. METHOD: Lifetime costs relating to periodontal treatment were modelled for a cohort of patients with type 2 diabetes...
May 15, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28498507/effect-of-surgical-periodontal-treatment-associated-to-antimicrobial-photodynamic-therapy-on-chronic-periodontitis-a-randomized-controlled-clinical-trial
#2
Sérgio H L Martins, Arthur B Novaes, Mario Taba, Daniela B Palioto, Michel R Messora, Danilo M Reino, Sérgio L S Souza
AIM: This randomized controlled clinical trial evaluated the effects of an adjunctive single application of antimicrobial photodynamic therapy (aPDT) in Surgical Periodontal Treatment (ST) in patients with severe chronic periodontitis (SCP). MATERIAL AND METHODS: In a split-mouth design, 20 patients with SCP were treated with aPDT+ST (Test Group, TG) or ST only (Control Group, CG). aPDT was applied in a single episode, using a diode laser and a phenothiazine photosensitizer...
May 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28498497/the-aggravation-of-arthritis-by-periodontitis-is-dependent-of-il-17-receptor-a-activation
#3
Sabrina G de Aquino, Jhimmy Talbot, Fabiane Sônego, Walter M Turato, Renata Grespan, Mario J Avila-Campos, Fernando Q Cunha, Joni A Cirelli
AIM: To evaluate whether Porphyromonas gingivalis-induced periodontitis aggravates the antigen-induced arthritis (AIA) model, and whether this effect is dependent on the Th17/IL-17 signalling pathway. MATERIALS AND METHODS: Antigen-induced arthritis was triggered by local injection of methylated bovine serum albumin into the knee joint of previously immunized C57BL/6 wild-type (WT) and IL-17 receptor A (IL-17RA)-knockout mice. Periodontal disease in naïve or arthritic mice was induced by oral infection with P...
May 12, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28477366/addition-of-enamel-matrix-derivatives-to-bone-substitutes-for-the-treatment-of-intrabony-defects-a-systematic-review-meta-analysis-and-trial-sequential-analysis
#4
REVIEW
Giuseppe Troiano, Luigi Laino, Khrystyna Zhurakivska, Marco Cicciù, Lorenzo Lo Muzio, Lucio Lo Russo
AIM: In order to enhance clinical improvement of intrabony defects, the addition of enamel matrix derivatives (EMD) to a bone substitues (BS) has been investigated. The aim of this systematic review is to figure out whether or not such a combination, in comparison to the treatment with a BS alone has beneficial effects on the following outcomes: clinical attachment level (CAL) gain, probing depth (PD) reduction and recession (REC). METHODS: Electronic databases (PUBMED, SCOPUS, EBSCO Host Research Databases and Web Of Knowledge) were searched for randomized controlled trials in humans addressing the use of a combination of BS and EMD versus a control group with BS alone for the treatment of intrabony defects, with a minimum of six months; meta-analysis and trial sequential analysis were then performed...
May 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28474783/discomfort-pain-due-to-periodontal-and-peri-implant-probing-implant-type-and-age
#5
Julia Ryska, Matthias Klum, Puria Parvini, Otto Zuhr, Katrin Nickles, Peter Eickholz
AIM: There is evidence that patients experience more discomfort/pain after peri-implant probing than periodontal probing. However, there are several plausible factors to additionally influence this observation: e.g. implant type, age, smoking. Thus, this study was designed to compare discomfort/pain after periodontal and peri-implant probing in different implant types. METHODS: 2 dentists recruited and examined 80 patients, each of them exhibiting a dental implant with a contralateral natural tooth...
May 5, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453878/titanium-implant-functionalization-with-phosphate-containing-polymers-may-favor-in-vivo-osseointegration
#6
Marcio V Cardoso, Judith de Rycker, Amol Chaudhari, Eduardo Coutinho, Yasuhiro Yoshida, Bart Van Meerbeek, Marcelo F Mesquita, Wander J da Silva, Kumiko Yoshihara, Katleen Vandamme, Joke Duyck
AIM: Osseointegration of titanium implants is predictable, but can be improved via surface functionalization. MATERIALS AND METHODS: 120 implants were installed in parietal bone of 12 domestic pigs and left to heal for 1 or 3 months. Five groups were defined according surface treatments: immersion in water (H2O), 10% polyphosphoric acid (PPA10), 1% phosphorylated pullulan (PPL1), 10% phosphorylated pullulan (PPL10), or 10% phosphorylated pullulan + 1 μg BMP-2 (PPL10 BMP)...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453869/nonsurgical-treatment-of-peri-implant-mucositis-and-peri-implantitis-at-two-piece-zirconium-implants-a-clinical-follow-up-observation-after-up-to-3-years
#7
G John, J Becker, A Schmucker, F Schwarz
OBJECTIVES: To assess the long-term clinical outcomes following nonsurgical therapy of peri-implant diseases at two-piece zirconium implants. MATERIAL & METHODS: A total of 27 patients suffering from either (i) peri-implant mucositis (n=24 implants) or (ii) peri-implantitis (n=16 implants) completed a mean follow-up period of 32.8±2.85 months (median: 34 months). The initial treatment procedures included (i) mechanical debridement + local antiseptic therapy using chlorhexidine digluconate (MD+CXH), or (ii) Er:YAG laser monotherapy (ERL)...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453865/saliva-and-plasma-levels-of-cardiac-related-biomarkers-in-post-myocardial-infarction-patients
#8
N Rathnayake, K Buhlin, B Kjellström, B Klinge, C Löwbeer, A Norhammar, L Rydén, T Sorsa, T Tervahartiala, A Gustafsson
AIM: To relate cardiac biomarkers, such as Cystatin C and Growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. MATERIALS AND METHODS: 200 patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453232/repair-of-large-saddle-defects-of-the-mandibular-ridge-using-dual-growth-factor-release-an-experimental-pilot-study-in-minipigs
#9
Markus Tröltzsch, Alexander Klenke, Petra Santander, Philipp Kauffmann, Matthias Tröltzsch, Anna Rau, Phillip Brockmeyer, Henning Schliephake
AIM: To test the hypothesis that the addition of small amounts of rhVEGF to rhBMP2 in a polymer carrier can accomplish equivalent repair effect as a reduced dosage of rhBMP2 compared to rhBMP2 alone. MATERIALS AND METHODS: Defects were created bilaterally in the mandibles of 18 minipigs. In 12 test animals, defects were filled with 0.5 g particulate PDLLA/CaCO3 composite loaded with 400 μg rhBMP2 / 50 μg rhVEGF165 on one side and 800 μg rhBMP2 on the other. After 4 and 13 weeks, the animals were evaluated each for area of new bone formation (mm²) and bone density (area %)...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453225/oral-infection-with-p-gingivalis-induces-peri-implantitis-in-a-murine-model-evaluation-of-bone-loss-and-the-local-inflammatory-response
#10
Rinat Tzach-Nahman, Gabriel Mizraji, Lior Shapira, Gabriel Nussbaum, Asaf Wilensky
AIM: Peri-implantitis is a major health concern, with unclear pathogenesis, and with no accessible animal models. Our aim was to establish a mouse model for peri-implantitis, and to investigate mediators of inflammation. MATERIALS AND METHODS: Mice were divided into implanted versus non-implanted groups. Implants were inserted immediately following the extraction of the upper first molar. Four weeks following implantation, implanted and non-implanted mice were challenged with either Porphyromonas gingivalis or vehicle (eight mice in each sub-group, thirty-two mice in total)...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453221/peri-implant-bone-density-around-implants-of-different-lengths-a-3-year-follow-up-of-a-randomized-clinical-trial
#11
P Sahrmann, P Schoen, N Naenni, R Jung, T Attin, P R Schmidlin
OBJECTIVES: Short dental implants are frequently placed, however, little is known about the effect of the loading force regarding an enhanced crown-to-implant ratio. The aim of this study was therefore to assess bone density changes after a three-year period, on radiographs acquired from a randomized controlled two-center clinical study comparing implants of 6 and 10 mm of length. MATERIALS AND METHODS: Three predefined areas were chosen on standardized X-rays in order to assess grey-scale values of the peri-implant bone: One at the tip of the apex and two at half-length on the mesial and distal sides of the implant...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28423193/is-the-use-of-differences-in-the-magnitude-of-cal-gain-appropriate-for-making-conclusions-on-the-efficacy-of-non-surgical-therapeutic-means
#12
Cristiano Tomasi, Jan L Wennström
The article "Network Meta-Analysis of Studies Included in the Clinical Practice Guideline on the Nonsurgical Treatment of Chronic Periodontitis" by John et al. (2017) compares clinical attachment level (CAL) gains among nine adjuncts to scaling and root planing (SRP). The authors concluded that adjuncts improve CAL gain by about a third of a millimetre over 6-12 months compared to SRP alone, without significant differences among the adjuncts. However, as discussed by the authors the patient-perceived benefit of this additional gain is unclear...
April 19, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28419559/impact-of-the-global-burden-of-periodontal-diseases-on-health-nutrition-and-wellbeing-of-mankind-a-call-for-global-action
#13
Maurizio S Tonetti, Søren Jepsen, Lijian Jin, Joan Otomo-Corgel
BACKGROUND: The global burden of periodontal diseases remains high. Population growth trends, changes in risk factors and improved tooth retention will increase the socio-economic burden of periodontitis that is responsible for 3.5 million years lived with disability, 54 billion USD/year in lost productivity and a major portion of the 442 billion USD/year cost for oral diseases. METHODS: In the context of the Milan World Exhibition 2015 "Feeding the Planet, Energy for Life," a green paper was developed and offered for global consultation by the European Federation of Periodontology...
April 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28419499/periodontitis-changes-renal-structures-by-oxidative-stress-and-lipid-peroxidation
#14
Luiz Felipe de Carvalho França, Any Carolina Cardoso Guimarães Vasconcelos, Felipe Rodolfo Pereira da Silva, Even Herlany Pereira Alves, Joaquina Dos Santos Carvalho, David Di Lenardo, Luan Kelves Miranda de Souza, André Luiz Dos Reis Barbosa, Jand-Venes Rolim Medeiros, Jefferson Soares de Oliveira, Daniel Fernando Pereira Vasconcelos
OBJECTIVE: The aim of this study was to investigate whether experimental periodontitis cause changes to the renal tissues and imbalance in oxidative stress in kidneys. METHODS: Twenty-two female Wistar rats were separated into two groups: control and periodontitis. We assessed the following parameters: gingival bleeding index (GBI), tooth mobility, gum malondialdehyde (MDA), myeloperoxidase (MPO) activity, probing pocket depth (PPD), alveolar bone loss (ABL) for periodontal tissues; histomorphometric measures associated with renal corpuscle and histopathological aspects (evaluation of brush border) for kidneys; as also blood and urine biomarkers...
April 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28419497/predictors-of-long-term-outcomes-in-patients-undergoing-periodontal-maintenance
#15
Pedro Martinez-Canut, Andrés Llobell, Antonio Romero
AIM: This retrospective study aimed to characterize the baseline status of patients following periodontal maintenance, analysing the association between the long-term outcome of these patients, smoking, bruxism and the main clinical and radiographic variables. MATERIAL AND METHODS: A sample of 174 patients with moderate to severe periodontitis was refined into homogeneous sub-samples according to smoking and bruxism and the rate of tooth loss due to periodontal disease (TLPD): 0, 1-2, and >2 teeth...
April 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28419494/increased-levels-of-soluble-cd163-in-periodontitis-patients
#16
Laurent Detzen, Steven C Y Chen, Bin Cheng, Panos N Papapanou, Evanthia Lalla
AIM: Soluble CD163 (sCD163) has been implicated as a new biomarker in inflammatory conditions. The aim of this cross-sectional study was to assess CD163 levels systemically and locally in patients with chronic periodontitis. METHODS: sCD163 levels were measured by ELISA in serum samples from 70 periodontitis and 70 periodontally healthy subjects, and in saliva samples in a subset of the population. Two gingival biopsies were harvested per subject from 20 periodontitis patients: one from a periodontally affected site, the other from a healthy site, and the relative expression of CD163 mRNA was assessed by real-time PCR...
April 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28382627/volumetric-changes-of-grafted-volumes-and-the-schneiderian-membrane-after-transcrestal-and-lateral-sinus-floor-elevation-procedures-a-clinical-pilot-study
#17
Andy Temmerman, Jeroen Vandessel, Simone Cortellini, Reinhilde Jacobs, Wim Teughels, Marc Quirynen
AIM: To investigate the influence of various surgical techniques for sinus augmentation on the volumetric changes of graft, membrane and the post-operative discomfort. MATERIALS AND METHODS: Eighteen patients in need of bilateral sinus floor elevation (SFE) were assigned to lateral SFE, transcrestal SFE and Intralift procedures. CBCT images taken at baseline, 1week and 6 weeks were analysed for volumetric changes in graft and Schneiderian membrane. Questionnaires were used to analyse post-op discomfort...
April 6, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28370333/network-meta-analysis-of-studies-included-in-the-clinical-practice-guideline-on-the-nonsurgical-treatment-of-chronic-periodontitis
#18
REVIEW
Mike T John, Bryan S Michalowicz, Georgios A Kotsakis, Haitao Chu
AIM: The recent ADA-commissioned Clinical Practice Guideline on the nonsurgical treatment of chronic periodontitis has provided the most exhaustive library of clinical trials on scaling and root planing (SRP) with or without adjuncts. This network meta-analysis compared the adjuncts against each other. MATERIALS AND METHODS: A star-shaped network meta-analysis was performed based on 36 indirect comparisons of clinical attachment level (CAL) gains among nine adjuncts in 74 studies from the Clinical Practice Guideline...
March 31, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28370244/autoantibodies-against-citrullinated-histone-h3-in-rheumatoid-arthritis-and-periodontitis-patients
#19
Koen M J Janssen, Menke J de Smit, Coenraad Withaar, Elisabeth Brouwer, Arie Jan van Winkelhoff, Arjan Vissink, Johanna Westra
AIM: To determine presence of citrullinated histones in inflamed periodontal tissue, and to determine presence of anti-citrullinated histone autoantibodies in sera from rheumatoid arthritis (RA) and periodontitis (PD)-patients . METHODS: Presence of citrullinated histone H3, PAD4 and CD68 was determined in 15 periodontal tissue biopsies from PD-patients by immunohistochemistry. Sera from 36 healthy controls (HC), 113 PD- and 84 RA-patients were assessed on presence of autoantibodies against citrullinated histones by Western blot and against citrullinated histone H3 by ELISA...
March 31, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28346753/association-between-diabetes-mellitus-hyperglycaemia-and-peri-implant-diseases-systematic-review-and-meta-analysis
#20
REVIEW
Alberto Monje, Andres Catena, Wenche S Borgnakke
AIM: This systematic review investigates whether hyperglycaemia/diabetes mellitus is associated with peri-implant diseases (peri-implant mucositis and peri-implantitis). MATERIALS AND METHODS: Electronic and manual literature searching was conducted. An a priori case definition for peri-implantitis was used as an inclusion criterion to minimize risk of bias. The Newcastle-Ottawa Scale was used for quality assessment; random effect models were applied; and results were reported according to the PRISMA Statement...
March 27, 2017: Journal of Clinical Periodontology
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