A Das, S K Yesupatham, D Allison, H Tanwar, J Gnanasekaran, B Kear, X Wang, S Wang, C Zachariadou, Y Abbasi, M K Chung, K Ozato, C Liu, B L Foster, V Thumbigere-Math
Interferon regulatory factor 8 (IRF8), a transcription factor expressed in immune cells, functions as a negative regulator of osteoclasts and helps maintain dental and skeletal homeostasis. Previously, we reported that a novel mutation in the IRF8 gene increases susceptibility to multiple idiopathic cervical root resorption (MICRR), a form of tooth root resorption mediated by increased osteoclast activity. The IRF8 G388S variant in the highly conserved C-terminal motif is predicted to alter the protein structure, likely impairing IRF8 function...
February 12, 2024: Journal of Dental Research