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Journal of Dental Research

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https://www.readbyqxmd.com/read/29342371/global-regional-and-country-level-economic-impacts-of-dental-diseases-in-2015
#1
A J Righolt, M Jevdjevic, W Marcenes, S Listl
Up-to-date information about the economic impact of dental diseases is essential for health care decision makers when seeking to make rational use of available resources. The purpose of this study was to provide up-to-date estimates for dental expenditures (direct costs) and productivity losses (indirect costs) due to dental diseases on the global, regional, and country level. Direct costs of dental diseases were estimated using a previously established systematic approach; indirect costs were estimated using an approach developed by the World Health Organization Commission on Macroeconomics and Health and factoring in 2015 values for gross domestic product and disability-adjusted life years from the Global Burden of Disease Study...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29342370/fgf8-signaling-alters-the-osteogenic-cell-fate-in-the-hard-palate
#2
J Xu, Z Huang, W Wang, X Tan, H Li, Y Zhang, W Tian, T Hu, Y P Chen
Fibroblast growth factor (FGF) signaling has been implicated in the regulation of osteogenesis in both intramembranous and endochondral ossifications. In the developing palate, the anterior bony palate forms by direct differentiation of cranial neural crest (CNC)-derived mesenchymal cells, but the signals that regulate the osteogenic cell fate in the developing palate remain unclear. In the present study, we investigated the potential role of FGF signaling in osteogenic fate determination of the palatal mesenchymal cells...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29342369/added-sugar-consumption-and-chronic-oral-disease-burden-among-adolescents-in-brazil
#3
C D S Carmo, M R C Ribeiro, J X P Teixeira, C M C Alves, M M Franco, A K T C França, B B Benatti, J Cunha-Cruz, C C C Ribeiro
Chronic oral diseases are rarely studied together, especially with an emphasis on their common risk factors. This study examined the association of added sugar consumption on "chronic oral disease burden" among adolescents, with consideration of obesity and systemic inflammation pathways through structural equation modeling. A cross-sectional study was conducted of a complex random sample of adolescent students enrolled at public schools in São Luís, Brazil ( n = 405). The outcome was chronic oral disease burden, a latent variable based on the presence of probing depth ≥4 mm, bleeding on probing, caries, and clinical consequences of untreated caries...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29328891/dysplasia-should-not-be-ignored-in-lichenoid-mucositis
#4
L D Rock, D M Laronde, I Lin, M P Rosin, B Chan, B Shariati, L Zhang
Oral lichen planus is categorized as a potentially malignant condition by the World Health Organization; however, some argue that only lichen planus with dysplasia have malignant potential. Many pathologists call lichen planus with dysplasia "dysplasia with lichenoid mucositis (LM)" or "LM with dysplasia." Previous research has shown that certain high-risk patterns of loss of heterozygosity (LOH) in dysplastic lesions are associated with significantly increased cancer risk. However, LM without dysplasia lacks such molecular patterns, supporting the hypothesis that LM, by itself, is not potentially malignant and that only those with dysplasia have malignant potential...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29328868/oral-sciences-phd-program-enrollment-graduates-and-placement-1994-to-2016
#5
C R Herzog, D W Berzins, P DenBesten, R L Gregory, K M Hargreaves, R L W Messer, M Mina, M P Mooney, M L Paine, C Phillips, R B Presland, R G Quivey, F A Scannapieco, J F Sheridan, K K H Svoboda, P C Trackman, M P Walker, S G Walker, C Y Wang, J C C Hu
For decades, dental schools in the United States have endured a significant faculty shortage. Studies have determined that the top 2 sources of dental faculty are advanced education programs and private practice. Those who have completed both DDS and PhD training are considered prime candidates for dental faculty positions. However, there is no national database to track those trainees and no evidence to indicate that they entered academia upon graduation. The objective of this study was to assess outcomes of dental school-affiliated oral sciences PhD program enrollment, graduates, and placement between 1994 and 2016...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29324076/brain-functional-changes-before-during-and-after-clinical-pain
#6
X Hu, A J Racek, E Bellile, T D Nascimento, M C Bender, R L Toback, D Burnett, L Khatib, R McMahan, I Kovelman, R P Ellwood, A F DaSilva
This study used an emerging brain imaging technique, functional near-infrared spectroscopy (fNIRS), to investigate functional brain activation and connectivity that modulates sometimes traumatic pain experience in a clinical setting. Hemodynamic responses were recorded at bilateral somatosensory (S1) and prefrontal cortices (PFCs) from 12 patients with dentin hypersensitivity in a dental chair before, during, and after clinical pain. Clinical dental pain was triggered with 20 consecutive descending cold stimulations (32° to 0°C) to the affected teeth...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29298397/impact-of-hotair-gene-polymorphism-and-environmental-risk-on-oral-cancer
#7
S C Su, M J Hsieh, C W Lin, C Y Chuang, Y F Liu, C M Yeh, S F Yang
Genetic and acquired factors are thought to be interrelated and imperative to estimate the risk and prognosis of oral squamous cell carcinoma (OSCC). HOX transcript antisense intergenic RNA ( HOTAIR) plays crucial roles in gene regulation and is regulated in a variety of cancers. Polymorphisms in HOTAIR have been recently linked to the predisposition to diverse malignancies. In the present study, we aimed to evaluate the influences of HOTAIR gene polymorphisms, combined with environmental triggers, on the susceptibility to oral tumorigenesis...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29298566/osteochondral-interface-stiffening-in-mandibular-condylar-osteoarthritis
#8
J Zhang, L Liao, J Zhu, X Wan, M Xie, H Zhang, M Zhang, L Lu, H Yang, D Jing, X Liu, S Yu, X L Lu, C Chen, Z Shan, M Wang
Osteoarthritis (OA) of the temporomandibular joint (TMJ) is associated with dental biomechanics. A major change during OA progression is the ossification of the osteochondral interface. This study investigated the formation, radiological detectability, and mechanical property of the osteochondral interface at an early stage, the pathogenesis significance of which in OA progression is of clinical interest and remains elusive for the TMJ. Unilateral anterior crossbite (UAC) was performed on 6-wk-old rats as we previously reported...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29298553/conserved-citrullinating-exoenzymes-in-porphyromonas-species
#9
G Gabarrini, M A Chlebowicz, M E Vega Quiroz, A C M Veloo, J W A Rossen, H J M Harmsen, M L Laine, J M van Dijl, A J van Winkelhoff
Porphyromonas gingivalis is one of the major oral pathogens implicated in the widespread inflammatory disorder periodontitis. Moreover, in recent years, P. gingivalis has been associated with the autoimmune disease rheumatoid arthritis. The peptidylarginine deiminase enzyme of P. gingivalis (PPAD) is a major virulence factor that catalyzes the citrullination of both bacterial and host proteins, potentially contributing to production of anticitrullinated protein antibodies. Considering that these antibodies are very specific for rheumatoid arthritis, PPAD appears to be a link between P...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29294298/zymography-of-hybrid-layers-created-using-extrafibrillar-demineralization
#10
L Gu, A Mazzoni, Y Gou, C Pucci, L Breschi, D H Pashley, L Niu, F R Tay
A chelate-and-rinse extrafibrillar calcium chelation dentin bonding concept has recently been developed and investigated for its effectiveness in improving resin-dentin bonding by bridging the gap between wet and dry dentin bonding. The objective of the present study was to evaluate the gelatinolytic activity of hybrid layers (HLs) created using the chelate-and-rinse bonding technique. Gelatinolytic activity within the HL was examined using in situ zymography and confocal laser-scanning microscopy after 24-h storage or after thermomechanical cycling...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29294297/ezh2-impairs-human-dental-pulp-cell-mineralization-via-the-wnt-%C3%AE-catenin-pathway
#11
B Li, F Yu, F Wu, T Hui, P A, X Liao, B Yin, C Wang, L Ye
The enhancer of zeste homolog 2 (EZH2) is a catalytic subunit of PRC2 (polycomb repressor complex 2). It mediates gene silencing via methyltransferase activity and is involved in the determination of cell lineage. However, the function of EZH2 and the underlying mechanisms by which it affects the differentiation of human dental pulp cell (hDPC) have remained underexplored. In this research, we found that EZH2 expression decreased during the mineralization of hDPCs, with attenuated H3K27me3 (trimethylation on lysine 27 in histone H3)...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29294296/integration-of-murine-and-human-studies-for-mapping-periodontitis-susceptibility
#12
A Nashef, R Qabaja, Y Salaymeh, M Botzman, M Munz, H Dommisch, B Krone, P Hoffmann, J Wellmann, M Laudes, K Berger, T Kocher, B Loos, N van der Velde, A G Uitterlinden, L C P G M de Groot, A Franke, S Offenbacher, W Lieb, K Divaris, R Mott, I Gat-Viks, E Wiess, A Schaefer, F A Iraqi, Y H Haddad
Periodontitis is one of the most common inflammatory human diseases with a strong genetic component. Due to the limited sample size of available periodontitis cohorts and the underlying trait heterogeneity, genome-wide association studies (GWASs) of chronic periodontitis (CP) have largely been unsuccessful in identifying common susceptibility factors. A combination of quantitative trait loci (QTL) mapping in mice with association studies in humans has the potential to discover novel risk loci. To this end, we assessed alveolar bone loss in response to experimental periodontal infection in 25 lines (286 mice) from the Collaborative Cross (CC) mouse population using micro-computed tomography (µCT) analysis...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29244957/hypercementosis-associated-with-enpp1-mutations-and-gaci
#13
V Thumbigere-Math, A Alqadi, N I Chalmers, M B Chavez, E Y Chu, M T Collins, C R Ferreira, K FitzGerald, R I Gafni, W A Gahl, K S Hsu, M S Ramnitz, M J Somerman, S G Ziegler, B L Foster
Mineralization of bones and teeth is tightly regulated by levels of extracellular inorganic phosphate (Pi) and pyrophosphate (PPi). Three regulators that control pericellular concentrations of Pi and PPi include tissue-nonspecific alkaline phosphatase (TNAP), progressive ankylosis protein (ANK), and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). Inactivation of these factors results in mineralization disorders affecting teeth and their supporting structures. This study for the first time analyzed the effect of decreased PPi on dental development in individuals with generalized arterial calcification of infancy (GACI) due to loss-of-function mutations in the ENPP1 gene...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29237131/adverse-effects-of-silver-diamine-fluoride-treatment-among-preschool-children
#14
D Duangthip, M H T Fung, M C M Wong, C H Chu, E C M Lo
This randomized clinical trial aimed to compare the adverse effects and parental satisfaction following the different regimes of silver diamine fluoride (SDF) treatment among preschool children. A total of 888 preschool children who had active dentin caries received different SDF application regimes: group 1, 12% SDF applied annually; group 2, 12% SDF applied semiannually; group 3, 38% SDF applied annually; and group 4, 38% SDF applied semiannually. Information on adverse effects-including tooth or gum pain, gum swelling, gum bleaching, and systemic toxicity-was collected through a parent-reported questionnaire within 1 wk after every SDF or placebo application...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29227715/human-papillomavirus-genome-integration-and-head-and-neck-cancer
#15
L M Pinatti, H M Walline, T E Carey
We conducted a critical review of human papillomavirus (HPV) integration into the host genome in oral/oropharyngeal cancer, reviewed the literature for HPV-induced cancers, and obtained current data for HPV-related oral and oropharyngeal cancers. In addition, we performed studies to identify HPV integration sites and the relationship of integration to viral-host fusion transcripts and whether integration is required for HPV-associated oncogenesis. Viral integration of HPV into the host genome is not required for the viral life cycle and might not be necessary for cellular transformation, yet HPV integration is frequently reported in cervical and head and neck cancer specimens...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29207917/functional-effects-of-snps-in-myh9-and-risks-of-nonsyndromic-orofacial-clefts
#16
Y Wang, D Li, Y Xu, L Ma, Y Lu, Z Wang, L Wang, W Zhang, Y Pan
Nonsyndromic orofacial clefts (NSOCs) are congenital newborn malformations. Myosin heavy chain 9 ( MYH9) is a candidate gene of NSOCs. To investigate the associations between single-nucleotide polymorphisms (SNPs) of MYH9 and NSOC susceptibility, a 2-stage case-control study was designed and 4 potentially functional SNPs of MYH9 (rs12107, rs2269529, rs9619601, rs5756130) were selected and genotyped by iPLEX Sequenom MassARRAY and TaqMan assay in the first stage (599 NSOC cases and 590 controls). The significant SNPs in the first stage were replicated in the second stage (676 NSOC cases and 705 controls) by TaqMan assay...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29202646/submucosal-diclofenac-for-acute-postoperative-pain-in-third-molar-surgery-a-randomized-controlled-clinical-trial
#17
P Gorecki, K D Rainsford, P Taneja, Y Bulsara, D Pearson, D Saund, B Ahmed, T Dietrich
Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID) for relief of inflammatory pain. A recent formulation combines this drug with hydroxypropyl-β-cyclodextrin (HPβCD) to improve its solubility and to enable subcutaneous administration. Previous studies confirmed the efficacy of this combination. This study's aim was to evaluate the efficacy, safety, and local tolerability of diclofenac HPβCD administered as a local submucosal injection prior to lower third molar surgery. We conducted a prospective, randomized, double-blind, placebo-controlled, parallel-group phase II single-center study...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29202640/a-comparative-assessment-of-implant-site-viability-in-humans-and-rats
#18
C-H Chen, X Pei, U S Tulu, M Aghvami, C-T Chen, D Gaudillière, M Arioka, M Maghazeh Moghim, O Bahat, M Kolinski, T R Crosby, A Felderhoff, J B Brunski, J A Helms
Our long-term objective is to devise methods to improve osteotomy site preparation and, in doing so, facilitate implant osseointegration. As a first step in this process, we developed a standardized oral osteotomy model in ovariectomized rats. There were 2 unique features to this model: first, the rats exhibited an osteopenic phenotype, reminiscent of the bone health that has been reported for the average dental implant patient population. Second, osteotomies were produced in healed tooth extraction sites and therefore represented the placement of most implants in patients...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29195058/essential-role-of-ift140-in-promoting-dentinogenesis
#19
G Li, M Liu, S Zhang, H Wan, Q Zhang, R Yue, X Yan, X Wang, Z Wang, Y Sun
Primary cilia, with highly regulated cellular sensory functions, play key roles in tissue development and function maintenance. Intraflagellar transport 140 (IFT140) is a subunit of IFT complex A, which is specialized for retrograde transportation in cilia. Mutations of Ift140 are usually associated with syndromic ciliopathy and may cause isolated diseases such as retinal dystrophy, short ribs, and polycystic kidney. However, the role of IFT140 in tooth development has not been well investigated. In this study, a close relationship between IFT140 and dentin formation is disclosed...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29195050/resilience-of-the-oral-microbiota-in-health-mechanisms-that-prevent-dysbiosis
#20
B T Rosier, P D Marsh, A Mira
Dental diseases are now viewed as a consequence of a deleterious shift in the balance of the normally stable resident oral microbiome. It is known that frequent carbohydrate consumption or reduced saliva flow can lead to caries, and excessive plaque accumulation increases the risk of periodontal diseases. However, when these "disease drivers" are present, while some individuals appear to be susceptible, others are more tolerant or resilient to suffering from undesirable changes in their oral microbiome. Health-maintaining mechanisms that limit the effect of disease drivers include the complex set of metabolic and functional interrelationships that develop within dental biofilms and between biofilms and the host...
November 1, 2017: Journal of Dental Research
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