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Journal of Dental Research

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https://www.readbyqxmd.com/read/28541773/induction-of-salivary-gland-like-cells-from-dental-follicle-epithelial-cells
#1
Q L Xu, A Furuhashi, Q Z Zhang, C M Jiang, T-H Chang, A D Le
The dental follicle (DF), most often associated with unerupted teeth, is a condensation of ectomesenchymal cells that surrounds the tooth germ in early stages of tooth development. In the present study, we aim to isolate epithelial stem-like cells from the human DF and explore their potential differentiation into salivary gland (SG) cells. We demonstrated the expression of stem cell-related genes in the epithelial components of human DF tissues, and these epithelial progenitor cells could be isolated and ex vivo expanded in a reproducible manner...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28535364/dental-decay-phenotype-in-nonsyndromic-orofacial-clefting
#2
B J Howe, M E Cooper, G L Wehby, J M Resick, N L Nidey, L C Valencia-Ramirez, A M Lopez-Palacio, D Rivera, A R Vieira, S M Weinberg, M L Marazita, L M Moreno Uribe
Although children with oral clefts have a higher risk for dental anomalies when compared with the general population, prior studies have shown conflicting results regarding their dental decay risk. Also, few studies have assessed dental decay risk in unaffected relatives of children with clefts. Thus, the question of increased risk of dental decay in individuals with oral clefts or their unaffected relatives is still open for empirical investigation. This study characterizes dental decay in the largest international cohort to date of children with nonsyndromic clefts and their relatives, as compared with controls, and it addresses whether families with oral clefts have a significantly increased risk for dental decay versus the general population...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28535361/maternal-smoking-during-pregnancy-is-associated-with-offspring-hypodontia
#3
A H Al-Ani, J S Antoun, W M Thomson, T R Merriman, M Farella
Little is known about environmental risk factors for hypodontia. The objective of this study was to investigate the association between hypodontia and common environmental risk factors, such as maternal smoking and alcohol and caffeine consumption during pregnancy. Eighty-three hypodontia cases with 1 or more missing permanent lateral incisors and/or 1 or more missing premolars were enrolled in this clinic-based case-control study. Some 253 controls with no missing teeth were frequency matched to cases by age and sex...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28535357/effects-of-composites-containing-bioactive-glasses-on-demineralized-dentin
#4
A Tezvergil-Mutluay, R Seseogullari-Dirihan, V P Feitosa, G Cama, D S Brauer, S Sauro
The aim of this study was to evaluate the degradation of completely demineralized dentin specimens in contact with a filler-free or 2 ion-releasing resins containing micrometer-sized particles of Bioglass 45S5 (BAG) or fluoride-containing phosphate-rich bioactive glass (BAG-F). Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were also used to evaluate the remineralization induced by the experimental ion-releasing resin-based materials. Dentin beams were totally demineralized in H3PO4 (10%) and placed in direct contact with a filler-free (RESIN) or 2 experimental ion-releasing resins (BAG or BAG-F) and immersed in artificial saliva (AS) up to 30 d...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28530844/developing-a-new-generation-of-antimicrobial-and-bioactive-dental-resins
#5
L Cheng, K Zhang, N Zhang, M A S Melo, M D Weir, X D Zhou, Y X Bai, M A Reynolds, H H K Xu
Dental caries is prevalent, and secondary caries causes restoration failures. This article reviews recent studies on developing a new generation of bioactive resins with anticaries properties. Extensive effects were made to develop new antimicrobial composites, bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque buildup and bacterial acid production. The effects of alkyl chain length and charge density and the antimicrobial mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent agents were discussed...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28521114/msc-ecm-cellular-complexes-induce-periodontal-tissue-regeneration
#6
M Takewaki, M Kajiya, K Takeda, S Sasaki, S Motoike, N Komatsu, S Matsuda, K Ouhara, N Mizuno, T Fujita, H Kurihara
Transplantation of mesenchymal stem cells (MSCs), which possess self-renewing properties and multipotency, into a periodontal defect is thought to be a useful option for periodontal tissue regeneration. However, developing more reliable and predictable implantation techniques is still needed. Recently, we generated clumps of an MSC/extracellular matrix (ECM) complex (C-MSC), which consisted of cells and self-produced ECM. C-MSCs can regulate their cellular functions in vitro and can be grafted into a defect site, without any artificial scaffold, to induce bone regeneration...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28521113/real-time-imaging-of-gap-progress-during-and-after-composite-polymerization
#7
J Hayashi, Y Shimada, J Tagami, Y Sumi, A Sadr
The aims of this study were to observe the behavior of composite and formation of gaps during and immediately after light polymerization using swept source optical coherence tomography (OCT) and to compare the interfacial integrity of adhesives in cavities through 3-dimensional (3D) image analysis. Forty tapered cylindrical cavities (4-mm diameter, 2-mm depth) were prepared in bovine incisors and restored using Bond Force (BF), Scotchbond Universal Adhesive (SBU), OptiBond XTR (XTR), or Clearfil SE Bond 2 (SE2), followed by Estelite Flow Quick flowable composite...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28521109/cost-effectiveness-of-caries-prevention-in-practice-a-randomized-controlled-trial
#8
C O'Neill, H V Worthington, M Donaldson, S Birch, S Noble, S Killough, L Murphy, M Greer, J Brodison, R Verghis, M Tickle
A 2-arm parallel-group randomized controlled trial measured the cost-effectiveness of caries prevention in caries-free children aged 2 to 3 y attending general practice. The setting was 22 dental practices in Northern Ireland. Participants were centrally randomized into intervention (22,600 ppm fluoride varnish, toothbrush, a 50-mL tube of 1,450 ppm fluoride toothpaste, and standardized prevention advice) and control (advice only), both provided at 6-monthly intervals during a 3-y follow-up. The primary outcome measure was conversion from caries-free to caries-active states assessed by calibrated and blinded examiners; secondary outcome measures included decayed, missing, or filled teeth surfaces (dmfs); pain; and extraction...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28521107/formation-of-fluorohydroxyapatite-with-silver-diamine-fluoride
#9
M L Mei, F Nudelman, B Marzec, J M Walker, E C M Lo, A W Walls, C H Chu
Silver diamine fluoride (SDF) is found to promote remineralization and harden the carious lesion. Hydroxyapatite crystallization is a crucial process in remineralization; however, the role of SDF in crystal formation is unknown. We designed an in vitro experiment with calcium phosphate with different SDF concentrations (0.38, 1.52, 2.66, 3.80 mg/mL) to investigate the effect of this additive on the nucleation and growth of apatite crystals. Two control groups were also prepared-calcium phosphate (CaCl2·2H2O + K2HPO4 in buffer solution) and SDF (Ag[NH3]2F in buffer solution)...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28511604/duplicated-or-hybridized-peptide-functional-domains-promote-oral-homeostasis
#10
T Basiri, N D Johnson, E B Moffa, Y Mulyar, P L Serra Nunes, M A A M Machado, W L Siqueira
Proteins that have existed for millions of years frequently contain repeats of functional domains within their primary structure, thereby improving their functional capacity. In the evolutionary young statherin protein contained within the in vivo-acquired enamel pellicle (AEP), we identified a single functional domain (DR9) located within the protein N-terminal portion that exhibits a higher affinity for hydroxyapatite and more efficient protection against enamel demineralization compared to other native statherin peptides...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28510511/corrigendum
#11
(no author information available yet)
Birkeland AC, Owen JH, Prince ME. 2015. Targeting head and neck cancer stem cells: current advances and future challenges. J Dent Res. 94(11):1516-1523. (Original DOI: 10.1177/0022034515601960 ) In this article, the funding source was not declared. The Acknowledgments have been updated in the online article as follows: Andrew Birkeland is a Research Fellow funded on a T32 Advanced Research Training in Otolaryngology Program Training Grant (T32 DC005356) funded by the National Institutes of Health NIDCD (National Institute On Deafness And Other Communication Disorders)...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28499097/substantivity-of-carbodiimide-inhibition-on-dentinal-enzyme-activity-over-time
#12
A Mazzoni, V Angeloni, N Sartori, S Duarte, T Maravic, L Tjäderhane, D H Pashley, F R Tay, L Breschi
The use of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide HCl (EDC) has recently been investigated for its effectiveness in the prevention of collagen degradation over time and the improvement of resin-dentin bond durability. The objective of the present study was to evaluate the effects of a 0.3 M EDC-containing conditioner on endogenous enzymatic activities within the hybrid layer (HL) created by a self-etch or an etch-and-rinse adhesive after 1 y. The activity within the HL was examined using in situ zymography and confocal laser scanning microscopy after 24 h or 1-y storage in artificial saliva...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28499095/trpm7-is-involved-in-volume-regulation-in-salivary-glands
#13
J M Kim, S Choi, K Park
Under hypotonic conditions, the regulatory volume decrease (RVD) is essential to maintain physiological homeostasis and functions in diverse biological systems. Intracellular Ca(2+) has been reported as an important mediator of this response, but the underlying Ca(2+) mechanism responsible for RVD is still controversial. Here we investigate the role of Ca(2+) in the RVD response using live-cell imaging, microspectrofluorimetry, and a patch-clamp technique. A typical RVD was observed in submandibular gland acinar cells after swelling in a hypotonic solution, whereas intracellular Ca(2+) chelation completely inhibited the RVD response...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28489513/thyroid-function-during-early-life-and-dental-development
#14
S Vucic, T I M Korevaar, B Dhamo, V W V Jaddoe, R P Peeters, E B Wolvius, E M Ongkosuwito
Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28489485/igf-1-mediates-ephrinb1-activation-in-regulating-tertiary-dentin-formation
#15
S Matsumura, A Quispe-Salcedo, C M Schiller, J S Shin, B M Locke, S Yakar, E Shimizu
Eph receptors belong to a subfamily of receptor tyrosine kinases that are activated by membrane-spanning ligands called ephrins. Previously, we demonstrated that the ephrinB1-EphB2 interaction regulates odontogenic/osteogenic differentiation from dental pulp cells (DPCs) in vitro. The goal of this study was to identify the molecular mechanisms regulated by the EphB2/ephrinB1 system that govern tertiary dentin formation in vitro and in vivo. During tooth development, ephrinB1, and EphB2 were expressed in preodontoblast and odontoblasts at postnatal day 4...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28489474/global-burden-of-sugar-related-dental-diseases-in-168-countries-and-corresponding-health-care-costs
#16
T Meier, P Deumelandt, O Christen, G I Stangl, K Riedel, M Langer
Oral diseases such as dental caries, edentulism (tooth loss), periodontal disease (PD), and oral cancer currently constitute an increased major public health burden across the globe, with significant differences between countries. One of the main drivers of caries, edentulism, and PD is the excessive intake of sugars. Here, we aimed to quantify the global sugar-related dental health and cost burden in the year 2010. This study used a health-econometrical model to calculate the disease burden as well as the direct and indirect costs attributable to the intake of free sugars (mono- and disaccharides [MDS])...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28486080/arginine-improves-ph-homeostasis-via-metabolism-and-microbiome-modulation
#17
M Agnello, L Cen, N C Tran, W Shi, J S McLean, X He
Dental caries can be described as a dysbiosis of the oral microbial community, in which acidogenic, aciduric, and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization. Alkali generation by oral microbes, specifically via arginine catabolic pathways, is an essential factor in maintaining plaque pH homeostasis. There is evidence that the use of arginine in dentifrices helps protect against caries. The aim of the current study was to investigate the mechanistic and ecological effect of arginine treatment on the oral microbiome and its regulation of pH dynamics, using an in vitro multispecies oral biofilm model that was previously shown to be highly reflective of the in vivo oral microbiome...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28481696/contribution-of-the-pdl-to-osteotomy-repair-and-implant-osseointegration
#18
X Pei, L Wang, C Chen, X Yuan, Q Wan, J A Helms
Our objective was to clarify the fate of the periodontal ligament (PDL) retained in the socket after tooth extraction, then determine if this tissue contributed to the osseointegration of "immediate" implants placed in these fresh extraction sockets. Mice underwent maxillary first molar extraction, the residual PDL was removed by an osteotomy, and titanium implants were placed. The osteotomy was created in such a way that the palatal surface was devoid of PDL remnants while the buccal, mesial, and distal surfaces retained PDL fibers...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28476093/association-of-condylar-bone-quality-with-tmj-osteoarthritis
#19
J Shi, S Lee, H C Pan, A Mohammad, A Lin, W Guo, E Chen, A Ahn, J Li, K Ting, J H Kwak
The etiology and treatment of temporomandibular joint (TMJ) osteoarthritis (TMJOA) remain complex and unclear. Based on clinical observations, we hypothesized that low condylar bone quality is significantly correlated with TMJOA and explored this association in a cross-sectional study with human patients. A total of 254 postmenopausal female participants were included in this study. Radiographic findings from cone beam computed tomography (CBCT) and clinical symptoms were used to classify each TMJ data sample as healthy control ( n = 124) or TMJOA ( n = 130)...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28467728/the-pf4-ppbp-cxcl5-gene-cluster-is-associated-with-periodontitis
#20
A Shusterman, M Munz, G Richter, S Jepsen, W Lieb, B Krone, P Hoffman, M Laudes, J Wellmann, K Berger, T Kocher, S Offenbacher, K Divaris, A Franke, S Schreiber, H Dommisch, E Weiss, A S Schaefer, Y Houri-Haddad, F A Iraqi
Periodontitis is a common dysbiotic inflammatory disease with an estimated heritability of 50%. Due to the limited sample size of available periodontitis cohorts and the underlying trait heterogeneity, genome-wide association studies (GWAS) of chronic periodontitis (CP) have been unsuccessful in discovering susceptibility factors. A strategy that combines agnostic GWAS with a well-powered candidate-gene approach has the potential to discover novel loci. We combined RNA-seq data from gingival tissues with quantitative trait loci (QTLs) that were identified in a F2-cross of mice resistant and susceptible to infection with oral bacterial pathogens...
May 1, 2017: Journal of Dental Research
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