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Journal of Dental Research

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https://www.readbyqxmd.com/read/27879422/a-new-definition-for-oral-health-implications-for-clinical-practice-policy-and-research
#1
EDITORIAL
J Y Lee, R G Watt, D M Williams, W V Giannobile
No abstract text is available yet for this article.
November 22, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27879421/loss-of-notch3-signaling-enhances-osteogenesis-of-mesenchymal-stem-cells-from-mandibular-torus
#2
X W Dou, W Park, S Lee, Q Z Zhang, L R Carrasco, A D Le
Mandibular torus (MT) is a common intraoral osseous outgrowth located on the lingual surface of the mandible. Histologic features include hyperplastic bone consisting of mature cortical and trabecular bone. Some theories on the etiology of MT have been postulated, such as genetic factors, masticatory hyperfunction, trauma, and continued growth, but the underlying mechanism remains largely unknown. In this study, we investigated the potential role of mesenchymal stem cells (MSCs) derived from human MT in the pathogenesis of bone outgrowth...
November 22, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27879420/saliva-and-serum-protein-exchange-at-the-tooth-enamel-surface
#3
D Heller, E J Helmerhorst, F G Oppenheim
The acquired enamel pellicle is an oral, fluid-derived protein layer that forms on the tooth surface. It is a biologically and clinically important integument that protects teeth against enamel demineralization, and abrasion. Tooth surfaces are exposed to different proteinaceous microenvironments depending on the enamel location. For instance, tooth surfaces close to the gingival sulcus contact serum proteins that emanate via this sulcus, which may impact pellicle composition locally. The aims of this study were to define the major salivary and serum components that adsorb to hydroxyapatite, to study competition among them, and to obtain preliminary evidence in an in vivo saliva/serum pellicle model...
November 22, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27872336/effect-of-free-sugars-on-diabetes-obesity-and-dental-caries
#4
LETTER
A R Tappuni, R Al-Kaabi, E Joury
No abstract text is available yet for this article.
November 21, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27872335/john-c-greene-1926-2016
#5
J S Greenspan
No abstract text is available yet for this article.
November 21, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27872334/antimicrobial-peptides-mechanisms-of-action-and-resistance
#6
REVIEW
B Bechinger, S-U Gorr
More than 40 antimicrobial peptides and proteins (AMPs) are expressed in the oral cavity. These AMPs have been organized into 6 functional groups, 1 of which, cationic AMPs, has received extensive attention in recent years for their promise as potential antibiotics. The goal of this review is to describe recent advances in our understanding of the diverse mechanisms of action of cationic AMPs and the bacterial resistance against these peptides. The recently developed peptide GL13K is used as an example to illustrate many of the discussed concepts...
November 21, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27872333/three-dimensional-analysis-of-enamel-crack-behavior-using-optical-coherence-tomography
#7
M S Segarra, Y Shimada, A Sadr, Y Sumi, J Tagami
The aim of this study was to nondestructively analyze enamel crack behavior on different areas of teeth using 3D swept source-optical coherence tomography (SS-OCT). Ten freshly extracted human teeth of each type on each arch (n = 80 teeth) were inspected for enamel crack patterns on functional, contact and nonfunctional, or noncontact areas using 3D SS-OCT. The predominant crack pattern for each location on each specimen was noted and analyzed. The OCT observations were validated by direct observations of sectioned specimens under confocal laser scanning microscopy (CLSM)...
November 21, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27864469/letter-to-the-editor-factors-influencing-early-dental-implant-failures
#8
LETTER
M Gossweiler
No abstract text is available yet for this article.
November 18, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27864468/response-to-the-letter-to-the-editor-factors-influencing-early-dental-implant-failures
#9
LETTER
B R Chrcanovic, J Kisch, T Albrektsson, A Wennerberg
No abstract text is available yet for this article.
November 18, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856968/estrogen-induced-monocytic-response-correlates-with-temporomandibular-disorder-pain-a-case-control-study
#10
M C Ribeiro-Dasilva, R B Fillingim, S M Wallet
Temporomandibular disorders (TMD) are a set of conditions characterized by pain and dysfunction in the temporomandibular joint and muscles of mastication. These pain conditions are associated with considerable morbidity, societal costs, and reduced quality of life. The prevalence varies between 4% and 10%, with females at higher risk, and a higher prevalence occurs during reproductive years. The increased prevalence of TMD in females and low prevalence in childhood reinforce that sex hormones, like estrogen, play an important, complex role in the pathophysiology of these disorders...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856967/nanosized-building-blocks-for-customizing-novel-antibiofilm-approaches
#11
A J Paula, H Koo
Recent advances in nanotechnology provide unparalleled flexibility to control the composition, size, shape, surface chemistry, and functionality of materials. Currently available engineering approaches allow precise synthesis of nanocompounds (e.g., nanoparticles, nanostructures, nanocrystals) with both top-down and bottom-up design principles at the submicron level. In this context, these "nanoelements" (NEs) or "nanosized building blocks" can 1) generate new nanocomposites with antibiofilm properties or 2) be used to coat existing surfaces (e...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856966/longitudinal-stability-of-common-tmj-structural-disorders
#12
E L Schiffman, M Ahmad, L Hollender, K Kartha, R Ohrbach, E L Truelove, L Zhang, J S Hodges, E Sommers, G C Anderson, Y M Gonzalez, X Guo, J O Look
The longitudinal course of temporomandibular joint (TMJ) disc displacement (DD) and degenerative joint disease (DJD) has never been conclusively described with magnetic resonance imaging and computed tomography, respectively. This 8-y observational study's objective was to assess the longitudinal stability of DD and DJD among 401 subjects. The Validation Project provided baseline measures; follow-up was performed in the TMJ Impact Project. With magnetic resonance imaging, 2 radiologists rendered a consensus diagnosis of normal/indeterminate, DD with reduction, or DD without reduction...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856965/hedgehog-pathway-mediated-vascular-alterations-following-trigeminal-nerve-injury
#13
N Moreau, W Dieb, A Mauborgne, S Bourgoin, L Villanueva, M Pohl, Y Boucher
Whereas neurovascular interactions in spinal neuropathic pain models have been well characterized, little attention has been given to such neurovascular interactions in orofacial neuropathic pain models. This study investigated in male Sprague-Dawley rats the vascular changes following chronic constriction injury (CCI) of the infraorbital nerve (IoN), a broadly validated preclinical model of orofacial neuropathic pain. Following IoN-CCI, an early downregulation of tight junction proteins Claudin-1 and Claudin-5 was observed within the endoneurium and perineurium, associated with increased local accumulation of sodium fluorescein (NaFlu) within the IoN parenchyma, as compared with sham animals...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856964/neonatal-satellite-cells-form-small-myotubes-in-vitro
#14
P L Carvajal Monroy, S Grefte, A M Kuijpers-Jagtman, J W Von den Hoff, F A D T G Wagener
Although palatal muscle reconstruction in patients with cleft palate takes place during early childhood, normal speech development is often not achieved. We hypothesized that the intrinsic properties of head satellite cells (SCs) and the young age of these patients contribute to the poor muscle regeneration after surgery. First, we studied the fiber type distribution and the expression of SC markers in ex vivo muscle tissue from head (branchiomeric) and limb (somite-derived) muscles from neonatal (2-wk-old) and young (9-wk-old) rats...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27837015/the-role-of-pannexin-3-in-bone-biology
#15
REVIEW
M Ishikawa, Y Yamada
Cell-cell and cell-matrix communications play important roles in both cell proliferation and differentiation. Gap junction proteins mediate signaling communication by exchanging small molecules and dramatically stimulating intracellular signaling pathways to determine cell fate. Vertebrates have 2 gap junction families: pannexins (Panxs) and connexins (Cxs). Unlike Cxs, the functions of Panxs are not fully understood. In skeletal formation, Panx3 and Cx43 are the most abundantly expressed gap junction proteins from each family...
November 11, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27834664/%C3%AE-sma-expressing-perivascular-cells-represent-dental-pulp-progenitors-in-vivo
#16
I Vidovic, A Banerjee, R Fatahi, B G Matthews, N A Dyment, I Kalajzic, M Mina
The goal of this study was to examine the contribution of perivascular cells to odontoblasts during the development, growth, and repair of dentin using mouse molars as a model. We used an inducible, Cre-loxP in vivo fate-mapping approach to examine the contributions of the descendants of cells expressing the αSMA-CreERT2 transgene to the odontoblast lineage. In vivo lineage-tracing experiments in molars showed the contribution of αSMA-tdTomato(+) cells to a small number of newly formed odontoblasts during primary dentinogenesis...
November 10, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27834299/novel-irf6-mutations-detected-in-orofacial-cleft-patients-by-targeted-massively-parallel-sequencing
#17
K D Khandelwal, N Ishorst, H Zhou, K U Ludwig, H Venselaar, C Gilissen, M Thonissen, I A L M van Rooij, K Dreesen, M Steehouwer, M van de Vorst, M Bloemen, E van Beusekom, J Roosenboom, W Borstlap, R Admiraal, T Dormaar, J Schoenaers, V Vander Poorten, G Hens, A Verdonck, S Bergé, N Roeleveldt, G Vriend, K Devriendt, H G Brunner, E Mangold, A Hoischen, H van Bokhoven, C E L Carels
Common variants in interferon regulatory factor 6 (IRF6) have been associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P) as well as with tooth agenesis (TA). These variants contribute a small risk towards the 2 congenital conditions and explain only a small percentage of heritability. On the other hand, many IRF6 mutations are known to be a monogenic cause of disease for syndromic orofacial clefting (OFC). We hypothesize that IRF6 mutations in some rare instances could also cause nonsyndromic OFC...
November 9, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27834298/birth-weight-breastfeeding-maternal-smoking-and-caries-trajectories
#18
E Bernabé, H MacRitchie, C Longbottom, N B Pitts, W Sabbah
Evidence for the effects of low birth weight, breastfeeding and maternal smoking on childhood caries is mainly cross-sectional. We examined the association of these 3 putative early life factors with caries increment over a 4-y period among young children. We used data from a 4-y longitudinal caries-risk assessment study carried out among Scottish children. Early life factors were measured when children were aged 1 y (baseline). Caries assessment was repeated annually from ages 1 to 4, and the number of decayed, missing and filled primary tooth surfaces (dmfs) were used as a repeated outcome measure...
November 9, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27827319/the-salivary-microbiome-and-oral-cancer-risk-a-pilot-study-in-fanconi-anemia
#19
C P Furquim, G M S Soares, L L Ribeiro, M A Azcarate-Peril, N Butz, J Roach, K Moss, C Bonfim, C C Torres-Pereira, F R F Teles
Fanconi anemia (FA) is a rare genetic disease characterized by chromosomal instability and impaired DNA damage repair. FA patients develop oral squamous cell carcinoma (OSCC) earlier and more frequently than the general population, especially after hematopoietic stem cell transplantation (HSCT). Although evidence of an etiological role of the local microbiome and carcinogenesis has been mounting, no information exists regarding the oral microbiome of FA patients. The aim of this study was to explore the salivary microbiome of 61 FA patients regarding their oral health status and OSCC risk factors...
November 8, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27821544/phosphate-and-vitamin-d-prevent-periodontitis-in-x-linked-hypophosphatemia
#20
M Biosse Duplan, B R Coyac, C Bardet, C Zadikian, A Rothenbuhler, P Kamenicky, K Briot, A Linglart, C Chaussain
X-linked hypophosphatemia (XLH) is a rare genetic skeletal disease where increased phosphate wasting in the kidney leads to hypophosphatemia and prevents normal mineralization of bone and dentin. Here, we examined the periodontal status of 34 adults with XLH and separated them according to the treatment they received for hypophosphatemia. We observed that periodontitis frequency and severity were increased in adults with XLH and that the severity varied according to the hypophosphatemia treatment. Patients who benefited from an early and continuous vitamin D and phosphate supplementation during their childhood presented less periodontal attachment loss than patients with late or incomplete supplementation...
November 7, 2016: Journal of Dental Research
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