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Journal of Dental Research

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https://www.readbyqxmd.com/read/30426815/identification-of-the-novel-tooth-specific-transcription-factor-amelod
#1
B He, Y Chiba, H Li, S de Vega, K Tanaka, K Yoshizaki, M Ishijima, K Yuasa, M Ishikawa, C Rhodes, K Sakai, P Zhang, S Fukumoto, X Zhou, Y Yamada
Basic-helix-loop-helix (bHLH) transcription factors play an important role in various organs' development; however, a tooth-specific bHLH factor has not been reported. In this study, we identified a novel tooth-specific bHLH transcription factor, which we named AmeloD, by screening a tooth germ complementary DNA (cDNA) library using a yeast 2-hybrid system. AmeloD was mapped onto the mouse chromosome 1q32. Phylogenetic analysis showed that AmeloD belongs to the achaete-scute complex-like ( ASCL) gene family and is a homologue of ASCL5...
November 14, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30412680/high-frequency-ultrasound-imaging-for-examination-of-early-dental-caries
#2
J Kim, T J Shin, H J Kong, J Y Hwang, H K Hyun
The extent of dental tissue destruction during the treatment of white spot lesions (WSLs) increases with the severity of the lesion. If the depth and shape of WSLs can be predicted with a noninvasive diagnostic method before dental caries treatment, more conservative interventions can be planned. Given the superiority of high-frequency ultrasound (HFUS) imaging in observing the internal structures of the body, the present study aimed to verify the possibility of HFUS imaging to examine the depth and shape of WSLs...
November 9, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30403904/a-novel-thermoresponsive-gel-as-a-potential-delivery-system-for-lipoxin
#3
B Wang, J Shao, J A Jansen, X F Walboomers, F Yang
The objective of this study was to evaluate a novel thermoresponsive polyisocyanopeptide (PIC)-based hydrogel as an injectable carrier for local drug delivery for periodontal applications. Three formulations of PIC gels, 0.2%, 0.5%, and 1% w/w, were prepared. As controls, commercially available poloxamer 407 (P407) gels of 20% and 26% w/w were used. Lipoxin A4 (LXA4 ), a proresolving drug, was suspended into the gel solutions. The systems were evaluated regarding dynamic mechanical properties, injectability and stability, release and bioactivity of LXA4 , and cytocompatibility...
November 7, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30392438/induction-of-m2-macrophages-prevents-bone-loss-in-murine-periodontitis-models
#4
Z Zhuang, S Yoshizawa-Smith, A Glowacki, K Maltos, C Pacheco, M Shehabeldin, M Mulkeen, N Myers, R Chong, K Verdelis, G P Garlet, S Little, C Sfeir
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio of proinflammatory M1 (classically activated) macrophages to anti-inflammatory M2 (alternatively activated). To decrease the inflammatory activity, we locally delivered the C-C motif chemokine ligand 2 (CCL2) using controlled-release microparticles (MPs)...
November 4, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30392435/integrated-epigenetic-mapping-of-human-and-mouse-salivary-gene-regulation
#5
D G Michael, T J F Pranzatelli, B M Warner, H Yin, J A Chiorini
Significant effort has been applied to identify the genome-wide gene expression profiles associated with salivary gland development and pathophysiology. However, relatively little is known about the regulators that control salivary gland gene expression. We integrated data from DNase1 digital genomic footprinting, RNA-seq, and gene expression microarrays to comprehensively characterize the cis- and trans-regulatory components controlling gene expression of the healthy submandibular salivary gland. Analysis of 32 human tissues and 87 mouse tissues was performed to identify the highly expressed and tissue-enriched transcription factors driving salivary gland gene expression...
November 4, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30392434/cpp-acp-promotes-snf-2-efficacy-in-a-polymicrobial-caries-model
#6
S G Dashper, P Shen, C P C Sim, S W Liu, C A Butler, H L Mitchell, T D'Cruze, Y Yuan, B Hoffmann, G D Walker, D V Catmull, C Reynolds, E C Reynolds
Dental caries is associated with plaque dysbiosis, leading to an increase in the proportions of acidogenic and aciduric bacteria at the expense of alkali-generating commensal species. Stannous fluoride (SnF2 ) slows the progression of caries by remineralization of early lesions but has also been suggested to inhibit glycolysis of aciduric bacteria. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) promotes fluoride remineralization by acting as a salivary biomimetic that releases bioavailable calcium and phosphate ions, and the peptide complex has also been suggested to modify plaque composition...
November 4, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30383477/purinergic-signaling-modulates-survival-proliferation-of-human-dental-pulp-stem-cells
#7
S Zhang, D Ye, L Ma, Y Ren, R T Dirksen, X Liu
Human dental pulp stem cells (hDPSCs) reside in postnatal dental pulp and exhibit the potential to differentiate into odontoblasts as well as neurons. However, the intercellular signaling niches necessary for hDPSC survival and self-renewal remain largely unknown. The objective of this study is to demonstrate the existence of intercellular purinergic signaling in hDPSCs and to assess the impact of purinergic signaling on hDPSC survival and proliferation. hDPSCs were isolated from extracted third molars and cultured in minimum essential medium...
November 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30383475/dr-steven-offenbacher-1950-2018
#8
J D Beck
No abstract text is available yet for this article.
November 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30372659/pulp-stem-cell-mediated-functional-pulp-regeneration
#9
B Sui, C Chen, X Kou, B Li, K Xuan, S Shi, Y Jin
The preservation of vital dental pulp with vasculature and nerve components remains one of the most significant challenges in modern dentistry. Due to the immense potential for neurovascularization, mesenchymal stem cell (MSC) transplantation has shown emerging promise in regenerative medicine and dental translational practice. Actually, pulp mesenchymal stem cells, including postnatal dental pulp stem cells (from permanent teeth) and stem cells from human exfoliated deciduous teeth, possess unique properties based on their origins from neural crest or glial cells...
October 29, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30359555/risk-of-myocardial-infarction-and-ischemic-stroke-after-dental-treatments
#10
T T Chen, F D'Aiuto, Y C Yeh, M S Lai, K L Chien, Y K Tu
The association between invasive dental treatments (IDTs) and a short-term risk of myocardial infarction (MI) and ischemic stroke (IS) remains controversial. Bacterial dissemination from the oral cavity and systemic inflammation linked to IDT can induce a state of acute vascular dysfunction. The aim of study is to investigate the relation of IDTs to MI and IS by using case-only study designs to analyze data from a large Taiwanese cohort. A nationwide population-based study was undertaken by using the case-crossover and self-controlled case series design to analyze the Taiwanese National Health Care Claim database...
October 25, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30359170/the-oral-microbiota-is-modified-by-systemic-diseases
#11
D T Graves, J D Corrêa, T A Silva
Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studies and in animal models, these diseases have been shown to enhance inflammation in the periodontium and increase the risk or severity of periodontitis. All 3 systemic diseases are linked to a decrease in bacterial taxa associated with health and an increase in taxa associated with disease...
October 25, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30354919/economic-evaluations-of-school-sealant-programs-and-the-consent-conundrum
#12
S S Huang, R Niederman
No abstract text is available yet for this article.
October 24, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30354846/genome-editing-a-new-horizon-for-oral-and-craniofacial-research
#13
N Yu, J Yang, Y Mishina, W V Giannobile
Precise and efficient genetic manipulations have enabled researchers to understand gene functions in disease and development, providing a platform to search for molecular cures. Over the past decade, the unprecedented advancement of genome editing techniques has revolutionized the biological research fields. Early genome editing strategies involved many naturally occurring nucleases, including meganucleases, zinc finger nucleases, and transcription activator-like effector-based nucleases. More recently, the clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR-associated nucleases (CRISPR/Cas) system has greatly enriched genetic manipulation methods in conducting research...
October 24, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30335555/sis-ecm-laden-with-gmsc-derived-exosomes-promote-taste-bud-regeneration
#14
Y Zhang, S Shi, Q Xu, Q Zhang, R M Shanti, A D Le
Oral cancer has a high annual incidence rate all over the world, and the tongue is the most frequently affected anatomic structure. The current standard care is ablative surgery of malignant neoplasm, followed by tongue reconstruction with free flap. However, such reconstructive modalities with postsurgery radiotherapy or chemotherapy can hardly support the functional recovery of the tongue-particularly, functional taste bud regeneration-in reconstructed areas, thus seriously affecting patients' prognosis and life quality...
October 18, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30326766/chitosan-based-extrafibrillar-demineralization-for-dentin-bonding
#15
L S Gu, X Cai, J M Guo, D H Pashley, L Breschi, H H K Xu, X Y Wang, F R Tay, L N Niu
Instability of resin-dentin bonds is the Achilles' heel of adhesive dentistry. To address this problem, a chelate-and-rinse extrafibrillar dentin demineralization strategy has been developed that keeps intrafibrillar minerals within collagen fibrils intact to prevent activation of endogenous proteases that are responsible for collagen degradation within hybrid layers. The objective of the present study was to evaluate the potential of using chitosan >40 kDa as an antimicrobial extrafibrillar dentin-chelating agent to enhance bond durability...
October 16, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30326764/effect-of-periodontal-treatment-on-hba1c-among-patients-with-prediabetes
#16
T Kocher, B Holtfreter, A Petersmann, P Eickholz, T Hoffmann, D Kaner, T S Kim, J Meyle, U Schlagenhauf, S Doering, M Gravemeier, K Prior, W Rathmann, I Harks, B Ehmke, R Koch
Evidence is limited regarding whether periodontal treatment improves hemoglobin A1c (HbA1c) among people with prediabetes and periodontal disease, and it is unknown whether improvement of metabolic status persists >3 mo. In an exploratory post hoc analysis of the multicenter randomized controlled trial "Antibiotika und Parodontitis" (Antibiotics and Periodontitis)-a prospective, stratified, double-blind study-we assessed whether nonsurgical periodontal treatment with or without an adjunctive systemic antibiotic treatment affects HbA1c and high-sensitivity C-reactive protein (hsCRP) levels among periodontitis patients with normal HbA1c (≤5...
October 16, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30325689/shh-plays-an-inhibitory-role-in-cusp-patterning-by-regulation-of-sostdc1
#17
J Kim, Y Ahn, D Adasooriya, E J Woo, H J Kim, K S Hu, R Krumlauf, S W Cho
Crown shapes in mammalian teeth vary considerably from species to species, and morphological characters in crown shape have been used to identify species. Cusp pattern is one of the characters in crown shape. In the processes governing the formation of cusp pattern, the Shh pathway has been implicated as an important player. Suppression of Shh signaling activity in vitro in explant assays appears to induce supernumerary cusp formation in wild-type tooth germs. However, the in vivo role of Shh signaling in cusp pattern formation and the molecular mechanisms by which Shh regulates cusp patterning are not clear...
October 16, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30290130/nonrestorative-treatments-for-caries-systematic-review-and-network-meta-analysis
#18
O Urquhart, M P Tampi, L Pilcher, R L Slayton, M W B Araujo, M Fontana, S Guzmán-Armstrong, M M Nascimento, B B Nový, N Tinanoff, R J Weyant, M S Wolff, D A Young, D T Zero, R Brignardello-Petersen, L Banfield, A Parikh, G Joshi, A Carrasco-Labra
The goal of nonrestorative or non- and microinvasive caries treatment (fluoride- and nonfluoride-based interventions) is to manage the caries disease process at a lesion level and minimize the loss of sound tooth structure. The purpose of this systematic review and network meta-analysis was to summarize the available evidence on nonrestorative treatments for the outcomes of 1) arrest or reversal of noncavitated and cavitated carious lesions on primary and permanent teeth and 2) adverse events. We included parallel and split-mouth randomized controlled trials where patients were followed for any length of time...
October 5, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30280949/response-to-letter-to-the-editor-impact-of-age-on-disease-progression-and-microenvironment-in-oral-cancer
#19
COMMENT
M Seshadri
No abstract text is available yet for this article.
October 3, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30280945/letter-to-the-editor-impact-of-age-on-disease-progression-and-microenvironment-in-oral-cancer
#20
COMMENT
N K Sharma, S C Sarode, G S Sarode, S Patil
No abstract text is available yet for this article.
October 3, 2018: Journal of Dental Research
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