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Willemien S Kalteren, Hendrik J Ter Horst, Anne E den Heijer, Leanne de Vetten, Elisabeth M W Kooi, Arend F Bos
BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology and neurodevelopmental effects are theoretically different from other causes of perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal anemia results in different short-term and long-term outcomes than other causes of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We retrospectively included infants with moderate to severe hypoxic-ischemic encephalopathy, born between May 2009 and October 2015...
July 19, 2018: Neonatology
Kasper Jacobsen Kyng, Anders Valdemar Edhager, Tine Brink Henriksen, Christer Zøylner Swan, Niels Gregersen, Johan Palmfeldt
BACKGROUND: Biomarkers may qualify diagnosis, treatment allocation, and prognostication in neonatal encephalopathy. Biomarker development is challenged by competing etiologies, inter-individual genetic variability, and a lack of specific neonatal markers. To address these challenges, we used a standardized neonatal hypoxic-ischemic (HI) encephalopathy model with pre- and post-HI sampling of cerebrospinal fluid (CSF) and plasma. OBJECTIVES: The study aimed to identify novel candidate protein biomarkers of HI encephalopathy in a newborn piglet model in CSF and plasma...
July 19, 2018: Neonatology
Mutaz Dana, Eitan Fibach
BACKGROUND: Fetal-maternal hemorrhage (FMH) occurs when fetal red blood cells (RBC) pass into the maternal circulation as a result of obstetric- or trauma-related complications to pregnancy. Their detection in the maternal blood is commonly used as a diagnostic test. There is, however, a serious and general limitation to this test that is sometimes ignored. Fetal RBC carrying the father's antigens (most crucially, the ABO blood antigens) may be incompatible with the mother's plasma. They are expected to be eliminated by the maternal natural antibodies, thus, negative results may be false...
July 16, 2018: Neonatology
Line Hedegaard Toftlund, Susanne Halken, Lone Agertoft, Gitte Zachariassen
BACKGROUND: Breastfeeding promotes healthy growth in very-preterm-born infants (VPI), but extra nutritional supply is needed to ensure catch-up growth and brain development. OBJECTIVES: To investigate how different types of post-discharge nutrition affect growth until 6 years of age in children born VPI. METHODS: This was a 6-year follow-up study of 281 VPI. Median gestational age (GA) was 30 + 0 weeks (range 24-32 weeks). When breastfed at discharge, they were randomized to unfortified human milk (UHM) or fortified human milk (FHM)...
July 16, 2018: Neonatology
Maria Elena Cavicchiolo, Francesco Cavallin, Federica Bertuola, Damiano Pizzol, Giulia Segafredo, Olivier Manzungu Wingi, Liviana Da Dalt, Giovanni Putoto, Daniele Trevisanuto
BACKGROUND: As intrapartum-related events represent a quarter of all neonatal deaths, education on neonatal resuscitation is a critical priority. OBJECTIVE: To assess the impact of a low-dose/high-frequency neonatal resuscitation training on clinical practice of midwives in a low-resource setting. METHODS: Eight months after a modified Neonatal Resuscitation Program (NRP) course, we implemented a low-dose/high-frequency training for midwives at Beira Central Hospital, Mozambique...
July 16, 2018: Neonatology
Daniel J C Berkhout, Patrick Klaassen, Hendrik J Niemarkt, Willem P de Boode, Veerle Cossey, Johannes B van Goudoever, Christiaan V Hulzebos, Peter Andriessen, Anton H van Kaam, Boris W Kramer, Richard A van Lingen, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Marc Benninga, Nanne K H de Boer, Tim G J de Meij
BACKGROUND: The identification of independent clinical risk factors for necrotizing enterocolitis (NEC) may contribute to early selection of infants at risk, allowing for the development of targeted strategies aimed at the prevention of NEC. OBJECTIVE: The objective of this study was to identify independent risk factors contributing to the development of NEC in a large multicenter cohort. METHODS: This prospective cohort study was performed in 9 neonatal intensive care units...
July 11, 2018: Neonatology
Kobi Best, Fiona Bogossian, Karen New
BACKGROUND: Elevated sound levels and low language exposures of preterm infants (< 37 weeks) cared for in the neonatal unit contribute to poorer growth, cognition, language and motor outcomes. These delays can have lasting effects on childhood development and continue throughout adult life. Whilst recommendations have been established for appropriate sound exposure levels in neonatal units, very little is known about the optimal level of language exposure. OBJECTIVES: To examine the evidence regarding language exposure, both measured (observational) and prescribed (interventional), in preterm infants (< 37 weeks) cared for in neonatal units and to identify optimal exposure levels to promote neurodevelopment...
July 4, 2018: Neonatology
Ken Imai, Linda S de Vries, Thomas Alderliesten, Nienke Wagenaar, Niek E van der Aa, Maarten H Lequin, Manon J N L Benders, Ingrid C van Haastert, Floris Groenendaal
BACKGROUND: Magnetic resonance imaging (MRI) is the standard neuroimaging technique to assess perinatal asphyxia-associated brain injury in full-term infants. Diffusion-weighted imaging (DWI) is most informative when assessed during the first week after the insult. OBJECTIVES: To study the DWI abnormalities of the thalamus and basal ganglia in full-term infants with perinatal asphyxia. METHODS: Fifty-five (near) term infants (normothermia n = 23; hypothermia n = 32) with thalamus and/or basal ganglia injury were included...
June 29, 2018: Neonatology
(no author information available yet)
No abstract text is available yet for this article.
June 26, 2018: Neonatology
Min-Sho Ku
BACKGROUND: Preventing the development of allergic skin disease in children is the best way to treat the disease. OBJECTIVES: Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children. METHODS: We randomly recruited 117,041 children from an insurance research database. Those with neonatal jaundice and receiving neonatal phototherapy were classified as the icteric-phototherapy group (n = 4,744), those with neonatal jaundice and not receiving phototherapy were classified as the icteric-non-phototherapy group (n = 5,003), and those without jaundice were classified as the non-icteric group (n = 107,294)...
June 25, 2018: Neonatology
Steven J Korzeniewski
No abstract text is available yet for this article.
June 25, 2018: Neonatology
Michael Kaplan, Ronald J Wong, David K Stevenson
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency affecting more than 300 million individuals worldwide. Extreme neonatal hyperbilirubinemia, with its severe sequelae of bilirubin neurotoxicity and the potential of death, is the most devastating manifestation of G6PD deficiency. In a recent review of Favism, Luzzatto and Arese state that the pathophysiology of jaundice in G6PD-deficient neonates is different from that of favism, as there is little evidence of hemolysis in these infants...
June 25, 2018: Neonatology
Veronique Demers-Mathieu, Mark A Underwood, Robert L Beverly, David C Dallas
BACKGROUND: Human milk immunoglobulins (Ig) are an important support for the naïve infant immune system; yet the extent to which these proteins survive within the infant digestive tract, particularly for preterm infants, is poorly studied. OBJECTIVES: Our objective was to evaluate the survival of human milk Igs in the preterm stomach across postprandial time. METHODS: Human milk and infant gastric samples were collected from 11 preterm (23-32 weeks gestational age) mother-infant pairs within 7-98 days postnatal age...
June 25, 2018: Neonatology
Carrie Torr, Bradley Yoder, Joanna Beachy
BACKGROUND: Retinopathy of prematurity (ROP) is a known complication of preterm birth and one of the leading causes of blindness. Known risk factors include low gestational age (GA), birth weight, and oxygen exposure. It is unknown if there are surgical risk factors associated with severe ROP. OBJECTIVES: Identify risk factors of a neonatal surgical exposure associated with laser therapy for ROP. METHODS: Institutional review of 76 infants with GA ≤27 weeks or birth weight ≤800 g...
June 25, 2018: Neonatology
Kate McCloskey, Alysha M De Livera, Fiona Collier, Anne-Louise Ponsonby, John B Carlin, Peter Vuillermin, Natalie A Mellett, Kaushala Jayawardana, Jacqueline M Weir, John Blangero, Joanne E Curran, David Burgner, Peter J Meikle
BACKGROUND: Lipid metabolism is vital to fetal development and cardiometabolic health and the final weeks of gestation are known to be a time of intense metabolic activity. New techniques such as lipidomics allow investigation of a complex lipidomic profile in infants. OBJECTIVES: This research aimed to (1) describe variations in lipidomic profile in late preterm and term infants and (2) compare variations to an adult lipidomic profile with known clinical implications...
June 25, 2018: Neonatology
Eva Morsing, Karel Maršál, David Ley
BACKGROUND: Very preterm (VPT) delivery after severe preeclampsia (PE) has been associated with adverse perinatal outcome. It is unclear whether fetal exposure to PE per se modifies the prevalence of neonatal morbidities associated with VPT birth. OBJECTIVES: To evaluate neonatal morbidity in VPT infants exposed to maternal PE compared to morbidity in nonexposed VPT infants. METHODS: This retrospective study consisted of all inborn infants delivered before 30 gestational weeks admitted to a tertiary-level neonatal intensive care unit between 1998 and 2014: 195 infants exposed to maternal PE were compared to 957 infants without maternal PE (background group)...
June 25, 2018: Neonatology
Elli Leppälehto, Anna Pärtty, Marko Kalliomäki, Eliisa Löyttyniemi, Erika Isolauri, Samuli Rautava
BACKGROUND: The aetiology of infantile colic remains unknown. However, altered gut microbiota composition has been reported in children with the disorder. OBJECTIVE: The objective of this study was to determine the associations between perinatal factors potentially affecting gut colonization and infantile colic. METHODS: Altogether 48 infants with colic and 29 controls were selected from 2 ongoing clinical studies. Infants with and without colic were comparable with regard to their background characteristics...
June 25, 2018: Neonatology
Allard E van Ark, Mirella C Molenschot, Maria H Wesseling, Willem B de Vries, Jan L M Strengers, Arthur Adams, Johannes M P J Breur
BACKGROUND: With the increasing incidence of births of very preterm very-low-birth-weight infants, there is a demand for echocardiographic reference values of cardiac dimensions. OBJECTIVES: The aim of this study was to provide reference values of cardiac valve annulus diameters in a cohort of extremely preterm very-low-birth-weight neonates and to correlate these with patient characteristics. METHODS: Valve diameters of 376 infants of < 32 weeks' gestation and with a birth weight of ≤2,000 g were measured using 2-dimensional echocardiography...
June 25, 2018: Neonatology
Jacqueline Salas, Aylin Tekes, Misun Hwang, Frances J Northington, Thierry A G M Huisman
Hypoxic-ischemic injury (HII) of the neonatal brain and resulting clinical hypoxic-ischemic encephalopathy remains a significant cause of morbidity and mortality in the neonatal population. Ultrasound (US) has emerged as a powerful screening tool for evaluation of a neonate with suspected HII. The pattern of injury on brain imaging has crucial implications in therapies and predicted neurodevelopmental outcomes. US has become increasingly effective at determining the pattern, timing, and extent of injury in HII as well as differentiating these findings from a host of diagnoses that can result in a similarly appearing clinical picture...
June 22, 2018: Neonatology
Richard J Cooke
No abstract text is available yet for this article.
June 19, 2018: Neonatology
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