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Hilde T Juvodden, Dag Alnæs, Martina J Lund, Ingrid Agartz, Ole A Andreassen, Espen Dietrichs, Per M Thorsby, Lars T Westlye, Stine Knudsen
Study Objectives: To assess white matter involvement in H1N1-vaccinated hypocretin deficient narcolepsy type 1 (NT1) patients compared with 1st degree relatives (a potential risk group), and healthy controls. Methods: We compared four diffusion tensor imaging-based microstructural indices (fractional anisotropy (FA), mean (MD), radial (RD), and axial diffusivity (AD)) in 57 NT1 patients (39 females, mean age 21.8 years, 51/57 H1N1-vaccinated, 57/57 HLA-DQB1*06:02-positive, 54/54 hypocretin-deficient), 54 1st degree relatives (29 females, mean age 19...
July 17, 2018: Sleep
Mathilde Flamand, Samuel Boudet, Renaud Lopes, Jean-Pierre Vignal, Nicolas Reyns, Christelle Charley-Monaca, Laure Peter-Derex, William Szurhaj
Study Objectives: Confusional arousals (CA) are characterized by the association of behavioral awakening with persistent slow-wave electro-encephalographic (EEG) activity during non-rapid eye movement sleep (NREM) - suggesting that sensorimotor areas are "awake" while non-sensorimotor areas are still "asleep". In the present work, we aimed to study the precise temporo-spatial dynamics of EEG changes in cortical areas during CA using intracerebral recordings. Methods: Nineteen episodes of CA were selected in five drug-resistant epileptic patients suffering incidentally from arousal disorders...
July 16, 2018: Sleep
Wendy M Troxel, Amy DeSantis, Andrea S Richardson, Robin Beckman, Bonnie Ghosh-Dastidar, Alvin Nugroho, Lauren Hale, Daniel J Buysse, Matthew P Buman, Tamara Dubowitz
Study Objectives: Neighborhood disadvantage has been linked to poor sleep. However, the extant research has primarily focused on self-reported assessments of sleep and neighborhood characteristics. The current study examines the association between objective and perceived neighborhood characteristics and actigraphy-assessed sleep duration, efficiency, and wakefulness after sleep onset (WASO) in an urban sample of African American adults. Methods: We examined data from predominantly African American adults (n= 788, mean age 55 years; 77% female) living in two low-income neighborhoods...
July 16, 2018: Sleep
Karan R Chadda, Ibrahim T Fazmin, Shiraz Ahmad, Haseeb Valli, Charlotte E Edling, Christopher L-H Huang, Kamalan Jeevaratnam
Heart failure (HF) affects 23 million people worldwide and results in 300,000 annual deaths. It is associated with many comorbidities, such as obstructive sleep apnoea (OSA), and risk factors for both conditions overlap. 11% of HF patients have OSA and 7.7% of OSA patients have left ventricular ejection fraction <50% with arrhythmias being a significant comorbidity in HF and OSA patients. 40% of HF patients develop atrial fibrillation (AF) and 30-50% of deaths from cardiac causes in HF patients are from sudden cardiac death...
July 16, 2018: Sleep
Sami Aboudhiaf, Georges Alves, Sandrine Parrot, Mohamed Amri, Mégane M Simonnet, Yael Grosjean, Gérard Manière, Laurent Seugnet
Amino-acid transporters are involved in functions reportedly linked to the sleep/wake cycle: neurotransmitter synthesis and recycling, the regulation of synaptic strength, protein synthesis and energy metabolism. In addition, the existence of bidirectional relationships between extracellular content, transport systems and sleep/wake states is receiving emerging support. Nevertheless, the connection between amino-acid transport and sleep/wake regulation remains elusive. To address this question, we used Drosophilamelanogaster and investigated the role of LAT1 (Large neutral Amino-acid Transporter 1) transporters...
July 16, 2018: Sleep
Jeongbin Park, Ji Won Han, Ju Ri Lee, Seonjeong Byun, Seung Wan Suh, Tae Kim, In Young Yoon, Ki Woong Kim
Study Objectives: Previous studies have shown that coffee consumption may suppress the production of melatonin in pinealocytes through competitive inhibition of adenosine A2 receptors by caffeine. We investigated the impact of lifetime coffee consumption on pineal gland volume and the resulting effects on sleep quality. Methods: We enrolled 162 cognitively normal elderly individuals among the participants in the Korean Longitudinal Study on Cognitive Aging and Dementia...
July 14, 2018: Sleep
Matteo Cesari, Julie A E Christensen, Lykke Kempfner, Alexander N Olesen, Geert Mayer, Karl Kesper, Wolfgang H Oertel, Friederike Sixel-Döring, Claudia Trenkwalder, Helge B D Sorensen, Poul Jennum
REM sleep without atonia (RSWA) detection is a prerequisite for diagnosis of REM sleep behavior disorder (RBD). As the visual gold standard method is time-consuming and subjective, several automated methods have been proposed.This study aims to compare their performances: The REM atonia index (RAI), the supra-threshold-REM-activity metric (STREAM), the Frandsen index (FRI), the short/long muscle activity indices (sMAI/lMAI) and the Kempfner index (KEI) algorithms were applied to 27 healthy control subjects (C), 25 Parkinson's disease (PD) patients without RBD (PD-RBD), 29 PD patients with RBD (PD+RBD), 29 idiopathic RBD patients and 36 patients with periodic limb movement disorder (PLMD)...
July 13, 2018: Sleep
Kathryn J Reid, Jia Weng, Alberto R Ramos, Phyllis C Zee, Martha Daviglus, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Linda C Gallo, Diana A Chirinos, Sanjay R Patel
Study Objectives: To describe sleep characteristics of shift workers compared to day workers from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sueño ancillary study, and test the hypothesis that shift work is associated with shorter sleep duration, worse sleep quality, greater sleep variability and other sleep/health related factors. Methods: Employed adults (N=1,253, mean age 46.3 years, 36.3% male) from the Sueño study were included. Measures of sleep duration, timing, regularity and continuity were calculated from 7-days of wrist-activity monitoring...
July 13, 2018: Sleep
Argelinda Baroni, Oliviero Bruni
No abstract text is available yet for this article.
July 10, 2018: Sleep
Jason R Carter, Daniela Grimaldi, Ida T Fonkoue, Lisa Medalie, Babak Mokhlesi, Eve Van Cauter
No abstract text is available yet for this article.
July 10, 2018: Sleep
Md Aftab Alam, Andrey Kostin, Jerome Siegel, Dennis McGinty, Ronald Szymusiak, Md Noor Alam
Growing evidence supports a role for the medullary parafacial zone in non-rapid eye movement (nonREM) sleep regulation. Cell-body specific lesions of the parafacial zone or disruption of its GABAergic/glycinergic transmission causes suppression of nonREM sleep, whereas, targeted activation of parafacial GABAergic/glycinergic neurons reduce sleep latency and increase nonREM sleep amount, bout duration, and cortical EEG slow-wave activity. Parafacial GABAergic/glycinergic neurons also express sleep-associated c-fos immunoreactivity...
July 7, 2018: Sleep
Geert Mayer, Giuseppe Plazzi, Álex Iranzo, Juan Ortega-Albás, Timothy Quinnell, Hanna Pesch, Pedro Serralheiro, Anne-Françoise Schlit, Didier Wuiame, Jürgen W G Bentz
Study Objectives: To evaluate adherence to sodium oxybate prescribing information for indication and dosage, patients' compliance with instructions for use, safety/tolerability in routine clinical practice, and abuse potential. Methods: A post-authorization, non-interventional surveillance study (NCT00244465) in patients who were prescribed sodium oxybate according to current practice by sleep disorders specialists. Patients were monitored for ≤18 months. Results: Overall, 749 patients were enrolled; 730 included in the intent-to-treat population (narcolepsy type 1 n=670, other indications n=60)...
July 7, 2018: Sleep
Sara S Frye, Julio Fernandez-Mendoza, Susan L Calhoun, Alexandros N Vgontzas, Duanping Liao, Edward O Bixler
Study Objectives: The purpose of this study is to examine the association of abnormal periodic limb movements (PLMS) with neurocognitive and behavioral outcomes in adolescents with attention-deficit/hyperactivity disorder (ADHD) from the general population. Methods: 421 adolescents (17.0±2.2y, 53.9% male) from the Penn State Child Cohort, a random general population sample, underwent 9-hour polysomnography, clinical history, physical examination, neurocognitive evaluation, and completed the Child or Adult Behavioral Checklist (C/ABCL)...
July 7, 2018: Sleep
Sonja Sulkava, Pranuthi Muggalla, Raimo Sulkava, Hanna M Ollila, Terhi Peuralinna, Liisa Myllykangas, Karri Kaivola, David J Stone, Bryan J Traynor, Alan E Renton, Alberto M Rivera, Seppo Helisalmi, Hilkka Soininen, Tuomo Polvikoski, Mikko Hiltunen, Pentti J Tienari, Henri J Huttunen, Tiina Paunio
Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer's disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer's disease. Previously, we have reported association of intolerance to shift work (job-related exhaustion in shift workers) with a variant rs12506228A, which is situated close to melatonin receptor type 1A gene (MTNR1A) and linked to MTNR1A brain expression levels. Here, we studied association of that variant with clinical and neuropathological Alzheimer's disease in a Finnish whole-population cohort Vantaa 85+ (n = 512, participants over 85 years) and two follow-up cohorts...
July 6, 2018: Sleep
Aimée Goldstone, Fiona C Baker, Massimilliano de Zambotti
No abstract text is available yet for this article.
July 5, 2018: Sleep
Galit Levi Dunietz, Leslie M Swanson, Erica C Jansen, Ronald D Chervin, Louise M O'Brien, Lynda D Lisabeth, Tiffany J Braley
Pain is common among older adults and negatively impacts functioning. Sleep disturbances and mood disorders, specifically depression and anxiety, are closely associated with pain in older individuals, but the directionality of these associations remains unclear. In this study, we deconstruct long-term temporal effects of two key insomnia symptoms on incident pain into direct and indirect pathways, with focus on depression and anxiety symptoms, within a nationally representative sample.We utilized 2011-2013 data from the National Health and Aging Trends Study, a longitudinal survey of 2,239 community-dwelling Medicare beneficiaries...
July 4, 2018: Sleep
Hyun-Min Seo, Tae Lim Kim, Joung Soo Kim
Study Objectives: The aim of our study was to investigate the risk of alopecia areata occurrence in patients with sleep disorders. Methods: This study was a retrospective cohort study based on the National Health Insurance Service-National Sample Cohort database of patients with a sleep disorder, along with age- and sex-matched control subjects from 2003 to 2013. The hazard ratio (HR) of alopecia areata was compared between the patients with sleep disorders and control subjects adjusting comorbid diseases which could affect the incidence of alopecia areata...
June 27, 2018: Sleep
Wayne R Lawrence, Mo Yang, Chuan Zhang, Ru-Qing Liu, Shao Lin, Si-Quan Wang, Yimin Liu, Huimin Ma, Duo-Hong Chen, Xiao-Wen Zeng, Bo-Yi Yang, Li-Wen Hu, Steve Hung Lam Yim, Guang-Hui Dong
Study Objectives: There is limited knowledge regarding the effects of air pollution on sleep disorders, particularly in children. The aim of this study is to investigate this association in Chinese children. Methods: During 2012-2013, 59754 children, aged 2-17 years were randomly selected from 27 districts in seven northeastern Chinese cities. All participants sleep was evaluated with the Sleep Disturbance Scale for Children. Four-year average concentrations of pollutants were calculated for particles with an aerodynamic diameter of ≤1µm (PM1), ≤2...
June 25, 2018: Sleep
Andrew W McHill, Charles A Czeisler, Steven A Shea
No abstract text is available yet for this article.
June 13, 2018: Sleep
F Büchele, C R Baumann, R Poryazova, E Werth, P O Valko
Study objective: Narcolepsy type 1 (NT1) is considered a chronic, incurable disease. Excessive daytime sleepiness is typically the most troublesome symptom, and more difficult to control by pharmacologic treatment than cataplexy. Although many NT1 patients are monitored by regular follow-ups, the purported relentless persistence of excessive daytime sleepiness has rarely been the object of longitudinal studies. Methods: Retrospective analysis of 26 well-defined hypocretin-deficient NT1 patients who underwent longitudinal assessments of Epworth Sleepiness Scale (ESS) scores under stable pharmacotherapy...
June 4, 2018: Sleep
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