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https://www.readbyqxmd.com/read/29346627/severe-and-protracted-sleep-disruptions-in-mouse-model-of-post-traumatic-stress-disorder
#1
Rishi Sharma, Pradeep Sahota, Mahesh M Thakkar
Increasing evidences suggest that the predator threat model is a valid animal model of post-traumatic stress disorder (PTSD). However, sleep has never been examined in this model. Since sleep disturbances, including insomnia and excessive daytime sleepiness, are severe and protracted symptoms of PTSD, we hypothesized that mice exposed to predator odor trauma (POT) will display contextual fear conditioning along with severe and protracted sleep disruptions.Adult male C57BL/6J mice, instrumented with wire electrodes [to record hippocampal field potentials (LFP) and nuchal muscle (EMG) activity], were exposed to contextual conditioning using soiled cat litter as unconditional stimulus (US)...
January 13, 2018: Sleep
https://www.readbyqxmd.com/read/29346624/data-driven-approaches-to-define-the-upper-limit-of-the-inter-movement-interval-of-periodic-leg-movements-during-sleep
#2
Raffaele Ferri, Alessandro Silvani, Francesco Rundo, Marco Zucconi, Debora Aricò, Oliviero Bruni, Luigi Ferini-Strambi, Mauro Manconi
Objective: to define statistically the upper limit of the inter-movement interval (IMI, the time interval between the onset of consecutive movements) of periodic leg movements during sleep (PLMS). Subjects and Methods: we computed the IMI distribution of a large sample (n = 141) of patients with restless legs syndrome (RLS) and analyzed it with two independent approaches, based on fitting either empirical functions or normal and exponential functions to the data...
January 13, 2018: Sleep
https://www.readbyqxmd.com/read/29329461/high-heritability-of-adolescent-sleep-wake-behavior-on-free-but-not-school-days-a-long-term-twin-study
#3
A P Inderkum, L Tarokh
Adolescence development is characterized by significant changes in sleep biology. Despite an overall decline in sleep duration and a delay in bedtime, significant inter-individual variation in sleep has been reported. The aim of the current study was to examine genetic and environmental influences on sleep in adolescence using long-term (6-month) actigraphy measurements, differentiating between school and free days. Sixteen monozygotic (MZ; n = 32) and 10 dizygotic (DZ; n = 20) twin pairs (mean age 12.8 ± 1...
January 10, 2018: Sleep
https://www.readbyqxmd.com/read/29329423/development-and-early-validation-of-a-patient-reported-outcome-measure-to-assess-sleep-amongst-people-experiencing-problems-with-alcohol-or-other-drugs
#4
Joanne Neale, Silia Vitoratou, Paul Lennon, Robert Meadows, Sarah Nettleton, Daria Panebianco, John Strang, John Marsden
Study Objectives: To develop a patient reported outcome measure to assess sleep amongst people experiencing problems with alcohol or other drugs. Methods: Item development included secondary analyses of qualitative interviews with drug/alcohol users in residential treatment, a review of validated sleep measures, focus groups with drug/alcohol users in residential treatment, and feedback from drug/alcohol users recruited from community and residential settings. An initial version of the measure was completed by 549 current and former drug/alcohol users (442 in person [IP] and 107 online [OL])...
January 10, 2018: Sleep
https://www.readbyqxmd.com/read/29329416/automatic-ecg-based-detection-of-autonomic-arousals-and-their-association-with-cortical-arousals-leg-movements-and-respiratory-events-in-sleep
#5
Mads Olsen, Logan Douglas Schneider, Joseph Cheung, Paul E Peppard, Poul J Jennum, Emmanuel Mignot, Helge Bjarup Dissing Sorensen
Study objectives: The current definition of sleep arousals neglects to address the diversity of arousals and their systemic cohesion. Autonomic arousals (AA) are autonomic activations often associated with cortical arousals (CA), but they may also occur in isolation in relation to a respiratory event, a leg movement event or spontaneously, without any other physiological associations. AA should be acknowledged as essential events to understand and explore the systemic implications of arousals...
January 10, 2018: Sleep
https://www.readbyqxmd.com/read/29325164/sleep-duration-in-the-united-states-2003-2016-first-signs-of-success-in-the-fight-against-sleep-deficiency
#6
Mathias Basner, David F Dinges
Study Objectives: The high prevalence of chronic insufficient sleep in the population has been a concern due to the associated health and safety risks. We evaluated secular trends in sleep duration over the most recent 14-year period. Methods: The American Time Use Survey (ATUS), representative of US residents ≥15 years, was used to investigate trends in self-reported sleep duration and waking activities for the period 2003-2016 (N=181,335 respondents). Results: Sleep duration increased across survey years both on weekdays (+1...
January 8, 2018: Sleep
https://www.readbyqxmd.com/read/29325155/sleep-findings-in-brazilian-children-with-congenital-zika-syndrome
#7
Luciana Pinato, Erlane M Ribeiro, Rebeka F P Leite, Thayse F Lopes, André L S Pessoa, Leila M Guissoni Campos, Giovanna E Piffer, Ana L D M Souza, Célia M Giacheti
Study Objectives: Zika virus infection during pregnancy may result in congenital Zika syndrome (CZS), whose characteristics are being described. Methods: The present study aimed to investigate the sleep characteristics of 136 infants/toddlers (88 with CZS and 48 with typical development (TD), age and gender matched, 60% girls and 40% boys in both groups) using the Brief Infant Sleep Questionnaire. The ages of children in both groups ranged from 5 to 24 months (CZS 15...
January 6, 2018: Sleep
https://www.readbyqxmd.com/read/29325115/fast-sleep-spindle-density-is-associated-with-rs4680-val108-158met-genotype-of-catechol-o-methyltransferase-comt
#8
Claudia Schilling, Lena Gappa, Michael Schredl, Fabian Streit, Jens Treutlein, Josef Frank, Michael Deuschle, Andreas Meyer-Lindenberg, Marcella Rietschel, Stephanie H Witt
Study Objectives: Sleep spindles are a hallmark of NREM stage 2 sleep. Fast sleep spindles correlate with cognitive functioning, and are reduced in schizophrenia. Although spindles are highly genetically determined, distinct genetic mechanisms influencing sleep spindle activity have not been identified so far. Spindles are generated within a thalamo-cortical network. Dopaminergic neurotransmission modulates activity within this network and importantly depends on activity of catechol-O-methyltransferase (COMT)...
January 6, 2018: Sleep
https://www.readbyqxmd.com/read/29325109/estimating-adolescent-sleep-need-using-dose-response-modelling
#9
Michelle A Short, Nathan Weber, Chelsea Reynolds, Scott Coussens, Mary A Carskadon
Study Objectives: This study will, (a) estimate the nightly sleep need of human adolescents, (b) determine the time course and severity of sleep-related deficits when sleep is reduced below this optimal quantity, and (c) determine whether sleep restriction perturbs the circadian system as well as the sleep homeostat. Methods: Thirty-four adolescents aged 15 to 17 years spent 10 days and 9 nights in the sleep laboratory. Between two baseline nights and two recovery nights with 10-hours' time in bed (TIB) per night, participants experienced either severe sleep restriction (5-hr TIB), moderate sleep restriction (7...
January 6, 2018: Sleep
https://www.readbyqxmd.com/read/29315434/recognizable-clinical-subtypes-of-osa-across-a-worldwide-sleep-center-population-a-cluster-analysis
#10
Brendan T Keenan, Jinyoung Kim, Bhajan Singh, Lia Bittencourt, Ning-Hung Chen, Peter A Cistulli, Ulysses Magalang, Nigel McArdle, Jesse W Mindel, Bryndis Benediktsdottir, Erna Sif Arnardottir, Lisa Kristin Prochnow, Thomas Penzel, Bernd Sanner, Richard Schwab, Chol Shin, Kate Sutherland, Sergio Tufik, Greg Maislin, Thorarinn Gislason, Allan I Pack
Study Objectives: A recent study of moderate-severe obstructive sleep apnea (OSA) patients in Iceland identified 3 clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort. Methods: Using data on 972 moderate-severe OSA patients [apnea-hypopnea index (AHI) ≥15 events/hour] recruited from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC) we performed a latent class analysis of 18 self-reported symptom variables, hypertension, cardiovascular disease and diabetes...
January 5, 2018: Sleep
https://www.readbyqxmd.com/read/29315422/dietary-therapy-restores-glutamatergic-input-to-orexin-hypocretin-neurons-after-traumatic-brain-injury-in-mice
#11
Jonathan E Elliott, Samuel E De Luche, Madeline J Churchill, Cindy Moore, Akiva S Cohen, Charles K Meshul, Miranda M Lim
Study Objectives: In previous work, dietary branched chain amino acid (BCAA) supplementation, precursors to de novo glutamate and gamma-aminobutyric acid (GABA) synthesis, restored impaired sleep-wake regulation and orexin neuronal activity post-traumatic brain injury (TBI) in mice. TBI was speculated to reduce orexin neuronal activity through decreased regional excitatory (glutamate) and/or increased inhibitory (GABA) input. Therefore, we hypothesized TBI would decrease synaptic glutamate and/or increase synaptic GABA in nerve terminals contacting orexin neurons, and BCAA supplementation would restore TBI-induced changes in synaptic glutamate and/or GABA...
January 5, 2018: Sleep
https://www.readbyqxmd.com/read/29309702/psychological-processes-associated-with-insomnia-in-patients-with-multiple-sclerosis
#12
Vanessa Schellaert, Pierre Labauge, Cindy Lebrun, Khaalid Hassan Maudarbocus, Jeanne Bernard, Jean-Baptiste Blache, Xavier Ayrignac, Clarisse Carra-Dallière, Marie-Christine Gély-Nargeot, Sophie Bayard
Study Objectives: Despite the high comorbidity of insomnia disorder (ID) with multiple sclerosis (MS), the relevance of psychological processes involved in the maintenance of insomnia is yet to be established in this neurological disorder. This study aimed to ascertain to what extent the suggested emotional, cognitive and behavioral processes maintaining insomnia are relevant in insomniac people with MS. Methods: A between-subjects design was used to compare 26 insomniac patients with MS, with 31 patients with MS only, and with 26 matched neurological disease-free insomniac individuals...
January 4, 2018: Sleep
https://www.readbyqxmd.com/read/29309697/cerebral-blood-flow-oxygen-metabolism-and-lactate-during-hypoxia-in-patients-with-obstructive-sleep-apnea
#13
M L F Jensen, M B Vestergaard, P Tønnesen, H B W Larsson, P J Jennum
Study objectives: Obstructive sleep apnea (OSA) is associated with increased risk of stroke but the underlying mechanism is poorly understood. We suspect that the normal cerebrovascular response to hypoxia is disturbed in patients with OSA. Methods: Global cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and lactate concentration during hypoxia were measured in patients with OSA and matched controls. 28 patients (82.1% males, mean age 52.3 ± 10...
January 4, 2018: Sleep
https://www.readbyqxmd.com/read/29301021/changing-faces-of-osa-treatment-effects-by-cluster-designation-in-the-icelandic-sleep-apnea-cohort
#14
Grace W Pien, Lichuan Ye, Brendan T Keenan, Greg Maislin, Erla Björnsdóttir, Erna Sif Arnardottir, Bryndis Benediktsdottir, Thorarinn Gislason, Allan I Pack
Study Objectives: Distinct clinical phenotypes of obstructive sleep apnea (OSA) have been identified: Disturbed Sleep, Minimally Symptomatic, and Sleepy. Determining whether these phenotypes respond differently to standard treatment helps create a foundation for personalized therapies. We compared responses to positive airway pressure (PAP) therapy in these clinical OSA phenotypes. Methods: The study sample included 706 patients from the Icelandic Sleep Apnea Cohort with moderate-to-severe OSA who were prescribed PAP...
January 2, 2018: Sleep
https://www.readbyqxmd.com/read/29309685/long-range-alpha-beta-and-short-range-gamma-eeg-synchronization-distinguishes-phasic-and-tonic-rem-periods
#15
Péter Simor, Ferenc Gombos, Borbála Blaskovich, Róbert Bódizs
Rapid Eye Movement (REM) sleep is characterized by the alternation of two markedly different microstates, phasic and tonic REM. These periods differ in awakening and arousal thresholds, sensory processing, and spontaneous cortical oscillations. Previous studies indicate that whereas in phasic REM, cortical activity is independent of the external environment, attentional functions and sensory processing are partially maintained during tonic periods. Large-scale synchronization of oscillatory activity, especially in the alpha and beta frequency ranges can accurately distinguish different states of vigilance and cognitive processes of enhanced alertness and attention...
December 23, 2017: Sleep
https://www.readbyqxmd.com/read/29309677/sleep-wakefulness-behaviors-in-mice-during-pregnancy-and-pregnancy-associated-hypertensive-mice
#16
Haruna Komiya, Chika Miyoshi, Kanako Iwasaki, Noriko Hotta-Hirashima, Aya Ikkyu, Satomi Kanno, Takato Honda, Masahiko Gosho, Hiromi Hamada, Toyomi Satoh, Akiyoshi Fukamizu, Hiromasa Funato, Masashi Yanagisawa
Study Objectives: In humans and other mammals, sleep is altered during pregnancy. However, no studies have been conducted on sleep/wakefulness during pregnancy in mice. In this study, we examined sleep/wakefulness in female C57BL/6 mice during pregnancy. We also examined sleep/wakefulness behaviors in an animal model of preeclampsia, pregnancy-associated hypertensive (PAH) mice, in which increased angiotensin causes hypertension. Methods: Sleep/wakefulness behaviors of female C57BL/6 mice and PAH mice were examined based on electroencephalogram (EEG)/electromyogram (EMG) recordings before, during and after pregnancy...
December 23, 2017: Sleep
https://www.readbyqxmd.com/read/29309669/cortical-autonomic-network-grey-matter-and-sympathetic-nerve-activity-in-obstructive-sleep-apnea
#17
Keri S Taylor, Philip J Millar, Hisayoshi Murai, Nobuhiko Haruki, Derek S Kimmerly, T Douglas Bradley, John S Floras
The sympathetic excitation elicited acutely by obstructive apnea during sleep (OSA) carries over into wakefulness. We hypothesized that OSA induces structural changes in the insula and cingulate, key central autonomic network (CAN) elements with projections to brainstem sympathetic premotor regions. The aims of this study were to: 1) apply two distinct but complementary methods (cortical thickness analysis [CTA] and voxel based morphometry [VBM]) to compare insula and cingulate grey matter thickness in subjects without and with OSA; 2) determine if oxygen desaturation index (ODI) relates to cortical thickness; and 3) determine if cortical thickness or volume in these regions predicts muscle sympathetic nerve (MSNA) burst incidence (BI)...
December 23, 2017: Sleep
https://www.readbyqxmd.com/read/29309703/sex-differences-in-sleep-patterns-and-changes-in-seventh-to-twelfth-graders-a-longitudinal-follow-up-study-in-taiwan
#18
Linen Nymphas Lin, Ling-Yin Chang, Baai-Shyun Hurng, Chi-Chen Wu, Lee-Lan Yen, Hsing-Yi Chang
Study Objectives: To assess the relationship between sex and the development of sleep patterns in adolescents from grade 7 to 12. Methods: We analyzed longitudinal data from annual school-based assessments of sleep habits among secondary school students in northern Taiwan. Measures of sleep patterns included sleep length on weekdays and weekends as well as weekend-weekday difference (WndD), defined as the discrepancy in the time in bed (TIB) between weekdays and weekends...
December 22, 2017: Sleep
https://www.readbyqxmd.com/read/29281091/self-reported-drowsiness-and-safety-outcomes-while-driving-after-an-extended-duration-work-shift-in-trainee-physicians
#19
Clare Anderson, Suzanne Ftouni, Joseph M Ronda, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
Objectives: Extended duration (≥24 h) work shifts (EDWS) are associated with increased risk of motor vehicle crashes, and awareness of any impairment has important implications on legal accountability for any adverse driving outcome. The extent to which adverse driving events were preceded by pre-drive self -reported sleepiness was evaluated in medical residents after EDWS. Methods: Sixteen resident physicians (10F;29.2±2.0y) working EDWS were monitored when driving on their commute to and from the hospital (438 drives)...
December 22, 2017: Sleep
https://www.readbyqxmd.com/read/29267979/mother-infant-sleep-patterns-and-parental-functioning-of-room-sharing-and-solitary-sleeping-families-a-longitudinal-study-from-3-to-18-months
#20
Ella Volkovich, Eran Bar-Kalifa, Gal Meiri, Liat Tikotzky
Study Objectives: To examine longitudinally differences in (a) objective and subjective sleep patterns and (b) parenting functioning (i.e., maternal emotional distress, maternal separation anxiety and parental involvement in infant care( between room-sharing and solitary sleeping mother-infant dyads. Methods: Maternal and infant sleep, sleeping arrangements and parental functioning were assessed at three (N=146), six (N=141), twelve (N=135), and eighteen (N=130) months postpartum...
December 16, 2017: Sleep
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