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Christopher B Forrest, Lisa J Meltzer, Carole L Marcus, Anna de la Motte, Amy Kratchman, Daniel J Buysse, Paul A Pilkonis, Brandon D Becker, Katherine B Bevans
Study Objectives: To develop and evaluate the measurement properties of child-report and parent-proxy versions of the PROMIS ® Pediatric Sleep Disturbance and Sleep-Related Impairment item banks. Methods: A national sample of 1,104 children (8-17 years-old) and 1,477 parents of children 5-17 years-old was recruited from an internet panel to evaluate the psychometric properties of 43 sleep health items. A convenience sample of children and parents recruited from a pediatric sleep clinic was obtained to provide evidence of the measures' validity; polysomnography data were collected from a subgroup of these children...
March 13, 2018: Sleep
Michelle R Zeidler, Jennifer L Martin, Eric C Kleerup, Hartmut Schneider, Michael N Mitchell, Nadia N Hansel, Krishna Sundar, Helena Schotland, Robert C Basner, James Wells, Jerry A Krishnan, Gerard J Criner, Stephanie Cristenson, Samuel Krachman, M Safwan Badr
Study Objectives: Sleep quality is poor among patients with COPD, and studies show sleep disturbance is associated with low overall quality of life in this population. We evaluated the impact of patient-reported sleep quality and sleep apnea risk on disease-specific and overall quality of life within COPD patients enrolled in the SPIROMICS study, after accounting for demographics and COPD disease severity. Methods: Baseline data from 1,341 participants [892 mild/moderate COPD (FEV1≥50% predicted); 449 severe COPD (FEV1<50%)], were used to perform three nested (blocks) regression models to predict quality of life (Short Form-12 mental and physical components and St...
March 9, 2018: Sleep
Philip Gehrman, Arjun Sengupta, Elizabeth Harders, Er Ubeydullah, Allan I Pack, Aalim Weljie
Study Objectives: Insomnia is a common sleep disorder that is associated with a range of adverse outcomes. Patients with insomnia exhibit hyperarousal in multiple domains, including an elevated metabolic rate, but specific metabolic molecular perturbations are unknown. Furthermore, objective clinical markers of insomnia are not available and current assessment of pathological extent relies on self-report. Here, we provide preliminary evidence that chronic insomnia is remarkably reflected in the periphery through detailed metabolic assessments...
March 7, 2018: Sleep
Alexis Roman, Soraya Meftah, Sébastien Arthaud, Pierre-Hervé Luppi, Christelle Peyron
Narcolepsy type 1 is a disabling disorder with four primary symptoms: excessive-daytime-sleepiness, cataplexy, hypnagogic hallucinations and sleep paralysis. The three latter symptoms together with a short REM sleep latency have suggested impairment in REM sleep homeostatic regulation with an enhanced propensity for (i.e. tendency to enter) REM sleep. To test this hypothesis, we challenged REM sleep homeostatic regulation in a recognized model of narcolepsy, the orexin knock-out (Orex-KO) mice and their wild-type (WT) littermates...
March 7, 2018: Sleep
Marjolein Schoonakker, Johanna H Meijer, Tom Deboer, Karim Fifel
The Lateral Hypothalamus (LH) is a relatively large hypothalamic structure containing several neurochemically different, but spatially intermingled, neuronal populations. While the role of these neurons in the homeostatic regulation of diverse physiological and behavioural functions such as sleep/wake cycle has been studied extensively, the impact of sleep history on the electrophysiology of the LH and whether this effect is homogenous across LH is unknown. By combining Multi-unit Activity (MUA) recordings in different regions of LH with electroencephalogram recordings in freely moving rats, we unravelled a heterogeneity of neural-activity patterns within different sub-regions of LH...
March 7, 2018: Sleep
Marco Filardi, Fabio Pizza, Elena Antelmi, Raffaele Ferri, Vincenzo Natale, Giuseppe Plazzi
Study Objectives: Sodium oxybate (SXB) is a GABAergic agent widely used as off-label treatment in pediatric type 1 narcolepsy (NT1). Here we aimed at analyzing by wrist actigraphy the sleep/wake profile of NT1 children and adolescents in drug-naïve condition and after 1 year of SXB treatment. As secondary aim, we investigated changes on sleepiness, cataplexy and children's anthropometric profile after 1 year of SXB treatment. Methods: Twenty-four drug-naïve NT1 children underwent seven days of actigraphy during the school week...
March 7, 2018: Sleep
Suzanne M Bertisch, Benjamin D Pollock, Murray A Mittleman, Daniel J Buysse, Lydia A Bazzano, Daniel J Gottlieb, Susan Redline
Study Objectives: To quantify the association between insomnia/poor sleep with objective short sleep and incident cardiovascular disease (CVD) and mortality in the general population. Methods: We conducted a time-to-event analysis of Sleep Heart Health Study data. Questionnaires and at-home polysomnography were performed between 1994 -1998. Participants were followed for a median 11.4 years (Q1-Q3, 8.8-12.4 years) until death or last contact. The primary exposure was insomnia or poor sleep with short sleep defined as: difficulty falling asleep, difficulty returning to sleep, early morning awakenings, or sleeping pill use, 16-30 nights/month; and total sleep <6 hours on polysomnography (PSG)...
March 7, 2018: Sleep
Jason R Carter, Daniela Grimaldi, Ida T Fonkoue, Lisa Medalie, Babak Mokhlesi, Eve Van Cauter
Study Objectives: Chronic insomnia affects up to 15% of adults. Recent cross-sectional and prospective epidemiological studies report an association between insomnia and hypertension, including incident hypertension, yet mechanisms underlying the association remain unknown. We hypothesized that subjects with chronic insomnia would have elevated sympathetic neural outflow, blunted baroreflex sensitivity, and augmented sympathetic neural and cardiovascular reactivity to stress when compared to good-sleeper controls...
March 7, 2018: Sleep
Louise Beattie
No abstract text is available yet for this article.
March 5, 2018: Sleep
Marie-Ève Desjardins, Andrée-Ann Baril, Jean-Paul Soucy, Thien Thanh Dang-Vu, Alex Desautels, Dominique Petit, Jacques Montplaisir, Antonio Zadra
Study objectives: The present study assessed brain perfusion patterns with single photon emission computed tomography (SPECT) during sleepwalkers' post-sleep deprivation slow-wave sleep and resting-state wakefulness. Methods: Following a 24-hr period of sleep deprivation, 10 sleepwalkers and 10 sex- and age-matched controls were scanned with a high-resolution SPECT scanner. Participants were injected with99mTc-ECD after 2 minutes of stable slow-wave sleep within their first sleep cycle as well as during resting-state wakefulness, both after a subsequent 24-hr period of sleep deprivation...
March 3, 2018: Sleep
Joshua G Davimes, Abdulaziz N Alagaili, Adhil Bhagwandin, Mads F Bertelsen, Osama B Mohammed, Nigel C Bennett, Paul R Manger, Nadine Gravett
Study objectives: The Arabian oryx lives under hyper-arid conditions in the Arabian Desert and exhibits temporal niche switching of activity patterns at a seasonal level. The objective of the current study was to provide a polysomnographic-based study of sleep in free-roaming Arabian oryx in their natural habitat to determine whether extreme seasonal climate variations resulted in changes in sleep patterns and physiology associated with the seasonal switching of temporal niches. Methods: Electroencephalography, nuchal electromyography, actigraphy and subcutaneous temperature were recorded in free-roaming Arabian oryx in the Mahazat as-Sayd Protected Area, Kingdom of Saudi Arabia during winter and summer...
February 21, 2018: Sleep
Stacey Gunn, Sreelatha Naik, Matt Travis Bianchi, Robert Joseph Thomas
Study Objectives: Adaptive servo ventilation (ASV) devices provide anti-cyclic pressure support for treatment of central/complex sleep apnea, including in heart failure patients. Variability in responses in the clinic and negative clinical trials motivated assessment of standard and novel signal biomarkers for ASV efficacy. Methods: Multiple clinical databases were queried to assess potential signal biomarkers of ASV effectiveness, including 1) Attended laboratory adaptive ventilation titrations: 108, of which 66 had mainstream ETCO2 measurements...
February 17, 2018: Sleep
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
Bharati Prasad, Alana D Steffen, Hans P A Van Dongen, Francis M Pack, Inna Strakovsky, Bethany Staley, David F Dinges, Greg Maislin, Allan I Pack, Terri E Weaver
Study Objectives: Significant interindividual variability in sleepiness is observed in clinical populations with obstructive sleep apnea (OSA). This phenomenon is only partially explained by the apnea-hypopnea index (AHI). Understanding factors that lead to sleepiness is critical to effective management of patients with OSA. We examined demographic and other factors associated with sleepiness in OSA. Methods: Prospective study of 283 patients with newly diagnosed OSA by polysomnography (AHI ≥ 5 per hour)...
February 10, 2018: Sleep
Xuewen Wang, Joshua R Sparks, Kimberly P Bowyer, Shawn D Youngstedt
Study Objectives: To examine the effects of moderate sleep restriction on body weight, body composition, and metabolic variables in individuals undergoing caloric restriction. Methods: Overweight or obese adults were randomized to an 8-week caloric restriction (CR) regimen alone (n=15) or combined with sleep restriction (CR+SR) (n=21). All participants were instructed to restrict daily calorie intake to 95% of their measured resting metabolic rate. Participants in the CR+SR group were also instructed to reduce time in bed on 5 nights and to sleep ad libitum on the other 2 nights each week...
February 9, 2018: Sleep
Bernd Feige, Svetoslava Nanovska, Chiara Baglioni, Benedict Bier, Laura Cabrera, Sarah Diemers, Maximilian Quellmalz, Markus Siegel, Ireni Xeni, Andras Szentkiralyi, John-Peter Doerr, Dieter Riemann
Study Objectives: Insomnia disorder (ID) is a frequent sleep disorder coupled with increased risks for somatic and mental illness. While subjective complaints are severe, polysomnography (PSG) parameters show only modest differences between groups. REM sleep as the most aroused sleep state may be especially vulnerable to be perceived as wake. To directly assess possible differences, we determined auditory waking thresholds and sleep perception in ID patients and healthy control subjects (GSC) in N2 and REM sleep...
February 8, 2018: Sleep
Ahmed Dalmar, Maharaj Singh, Bennet Pandey, Christopher Stoming, Zoe Heis, Khawaja Afzal Ammar, M Fuad Jan, Indrajit Choudhuri, Thomas Y Chua, Jasbir Sra, A Jamil Tajik, Arshad Jahangir
Weight loss after bariatric surgery is associated with reduction in adverse cardiovascular outcomes; however, the impact of obstructive sleep apnea (OSA) on reduction of cardiovascular outcomes after bariatric surgery in morbidly obese patients is not known. We retrospectively assessed differences in cardiovascular events after laparoscopic adjustable gastric banding (LAGB)-induced weight loss in patients with and without OSA before and after propensity score matching for age, sex, body mass index (BMI), and major comorbidities between the two groups and determined predictors of poor outcomes...
February 7, 2018: Sleep
Fabio Pizza, Elena Antelmi, Stefano Vandi, Stefano Meletti, Roberto Erro, Christian R Baumann, Kailash P Bhatia, Yves Dauvilliers, Mark J Edwards, Alex Iranzo, Sebastiaan Overeem, Michele Tinazzi, Rocco Liguori, Giuseppe Plazzi
Objectives: To describe the motor pattern of cataplexy and to determine its phenomenological differences from pseudocataplexy in the differential diagnosis of episodic falls. Methods: We selected 30 video recorded cataplexy and 21 pseudocataplexy attacks in 17 and 10 patients evaluated for suspected narcolepsy and with final diagnosis of narcolepsy type 1 and conversion disorder respectively, together with self-reported attacks features, and asked expert neurologists to blindly evaluate the motor features of the attacks...
February 7, 2018: Sleep
Mihoko Shimada, Taku Miyagawa, Hiromi Toyoda, Katsushi Tokunaga, Makoto Honda
Narcolepsy with cataplexy, which is a hypersomnia characterized by excessive daytime sleepiness and cataplexy, is a multifactorial disease caused by both genetic and environmental factors. Several genetic factors including HLA-DQB1*06:02 have been identified, however the disease etiology is still unclear. Epigenetic modifications, such as DNA methylation, have been suggested to play an important role in the pathogenesis of complex diseases. Here we examined DNA methylation profiles of blood samples from narcolepsy and healthy control individuals, and performed an epigenome-wide association study (EWAS) to investigate methylation loci associated with narcolepsy...
February 7, 2018: Sleep
Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow, Henrik Zetterberg
Study Objective: To investigate the cumulative effect of 5 consecutive nights of partial sleep deprivation on a panel of cerebrospinal fluid (CSF) biomarkers in healthy adults. Methods: A randomized, cross-over study conducted at the University of Gothenburg. The participants (N=13) were healthy adults (20-40 years of age) with a normal sleeping pattern. The participants underwent a baseline sleep period consisting of 5 nights with 8h spent in bed. A subsequent period with partial sleep deprivation (PSD) consisted of 5 nights of maximum 4h of sleep per night...
February 7, 2018: Sleep
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